f sequence dc when two letters picked without replacement from ccyeycchfyyedycye.

5/272
What is prob of sequence huuh when four letters picked without replacement from uuuuhuuhuuuu?

1/66
Calculate prob of sequence ochh when four letters picked without replacement from ohmoohoohhcmo.

3/715
Three letters picked without replacement from pypkytpyppptpttt.

1/32
Four letters picked without replacement from {m: 7, x: 6, w: 2, h: 3, l: 1}.

7/7752
What is prob of sequence wdmw when four letters picked without replacement from {b: 6, d: 1, w: 2, m: 2, z: 1}?

1/2970
Two letters picked without replacement from {j: 2, f: 2}.

1/3
Calculate prob of sequence bbtg when four letters picked without replacement from qejqbgtb.

1/840
Calculate prob of sequence tk when two letters picked without replacement from {m: 1, k: 1, g: 1, t: 2}.

1/10
Two letters picked without replacement from {l: 4, d: 5, h: 10}.

10/171
Four letters picked without replacement from wwiiwiw.

3/35
Two letters picked without replacement from {k: 5, v: 1, y: 4, i: 2, p: 2, w: 1}.

4/105
What is prob of sequence eee when three letters picked without replacement from eededve?

4/35
What is prob of sequence jjd when three letters picked without replacement from dddddjjjvjjdjjjdid?

14/153
Three letters picked without replacement from {r: 2, o: 2, b: 1, u: 1}.

1/30
Three letters picked without replacement from {s: 2, u: 2, w: 4, c: 3, l: 3, r: 2}.

1/140
Two letters picked without replacement from fhjhfhowfffohj.

10/91
What is prob of sequence yh when two letters picked without replacement from yyxyh?

3/20
Three letters picked without replacement from {r: 1, y: 1, m: 1, b: 1, f: 1}.

1/60
Three letters picked without replacement from utwutgluutluttt.

2/455
Calculate prob of sequence pe when two letters picked without replacement from {e: 1, j: 1, s: 1, p: 2}.

1/10
Four letters picked without replacement from {l: 4, q: 3, c: 4, x: 1, i: 2}.

1/1001
What is prob of sequence rh when two letters picked without replacement from {r: 1, h: 18}?

1/19
What is prob of sequence rppp when four letters picked without replacement from {p: 3, r: 1}?

1/4
Three letters picked without replacement from {p: 5, f: 6, e: 3, z: 1}.

1/455
Three letters picked without replacement from xlllllxl.

1/28
Two letters picked without replacement from mmmmmtmmmmmmmmtmtmmm.

51/380
Four letters picked without replacement from {n: 6, l: 2, e: 5, p: 2, c: 3, v: 1}.

5/23256
Two letters picked without replacement from ttdvomi.

1/42
Two letters picked without replacement from rerrree.

1/7
Two letters picked without replacement from weeweyweewe.

3/55
Calculate prob of sequence uu when two letters picked without replacement from {u: 5, s: 5}.

2/9
Four letters picked without replacement from {a: 8, v: 5}.

28/429
Calculate prob of sequence skap when four letters picked without replacement from kaspp.

1/60
Calculate prob of sequence nt when two letters picked without replacement from {n: 2, t: 1}.

1/3
What is prob of sequence hhch when four letters picked without replacement from {c: 4, h: 6}?

2/21
What is prob of sequence fix when three letters picked without replacement from ifffxifxxfuffffx?

3/140
What is prob of sequence cx when two letters picked without replacement from {x: 7, c: 1, o: 2, w: 2, p: 2, r: 1}?

1/30
What is prob of sequence ss when two letters picked without replacement from wswswssswss?

21/55
Calculate prob of sequence rm when two letters picked without replacement from {m: 2, p: 1, r: 1}.

1/6
Calculate prob of sequence xf when two letters picked without replacement from {n: 2, p: 5, d: 2, f: 8, c: 2, x: 1}.

2/95
Two letters picked without replacement from {x: 7, r: 3, b: 9}.

3/38
Four letters picked without replacement from {d: 4, h: 2, p: 1}.

1/35
Four letters picked without replacement from {m: 1, g: 2, n: 1, v: 3}.

1/140
Four letters picked without replacement from nnnznznnn.

1/36
Two letters picked without replacement from {s: 2, j: 1, n: 1, k: 2}.

1/15
Three letters picked without replacement from {w: 5, s: 1, n: 8, z: 2, b: 3}.

56/2907
Calculate prob of sequence lp when two letters picked without replacement from {p: 4, k: 5, l: 8}.

2/17
Calculate prob of sequence lf when two letters picked without replacement from {y: 1, s: 2, f: 3, l: 1}.

1/14
What is prob of sequence uuu when three letters picked without replacement from uvvuvuuvvvuv?

1/22
Calculate prob of sequence mva when three letters picked without replacement from {a: 1, p: 1, v: 3, m: 2}.

1/35
Calculate prob of sequence rep when three letters picked without replacement from {f: 1, p: 2, i: 1, l: 3, e: 1, r: 3}.

1/165
What is prob of sequence cgcc when four letters picked without replacement from ggggccgc?

1/56
Calculate prob of sequence xfxx when four letters picked without replacement from fxxxxxxxxxxf.

4/33
Four letters picked without replacement from {s: 8, f: 2, r: 1, o: 1, x: 1, g: 1}.

1/3003
Calculate prob of sequence ww when two letters picked without replacement from {b: 11, w: 5}.

1/12
What is prob of sequence ckk when three letters picked without replacement from {k: 4, c: 3, q: 3, d: 2, g: 6}?

1/136
Three letters picked without replacement from eeegeiigieeiggi.

4/455
Four letters picked without replacement from {z: 3, w: 4, c: 3, a: 2, y: 3, q: 1}.

3/3640
Calculate prob of sequence gyg when three letters picked without replacement from {y: 2, g: 4, m: 6}.

1/55
Calculate prob of sequence qh when two letters picked without replacement from hihihhhhhihhrhhhqpqh.

13/190
Two letters picked without replacement from dhddddddhddh.

1/22
What is prob of sequence rddd when four letters picked without replacement from ddrdr?

1/10
Two letters picked without replacement from tffow.

1/10
Four letters picked without replacement from qrrymmrqmymmymmmr.

1/85
Four letters picked without replacement from {r: 1, o: 1, n: 2, f: 1, t: 1, c: 1}.

1/420
Three letters picked without replacement from {r: 2, k: 7}.

1/36
Two letters picked without replacement from {y: 2, r: 4, t: 2, l: 5, s: 1}.

5/182
Four letters picked without replacement from {y: 1, j: 6, a: 1, k: 3, l: 1}.

1/330
Calculate prob of sequence qzqt when four letters picked without replacement from {q: 2, t: 1, z: 1}.

1/12
Calculate prob of sequence iu when two letters picked without replacement from {h: 2, i: 5, z: 3, u: 1, t: 1}.

5/132
What is prob of sequence hwec when four letters picked without replacement from {d: 1, w: 1, q: 1, h: 2, c: 2, e: 1}?

1/420
Four letters picked without replacement from {v: 6, t: 3, e: 2, a: 3, o: 2}.

3/1820
Calculate prob of sequence xzgn when four letters picked without replacement from {g: 1, x: 2, l: 1, v: 1, n: 1, z: 2}.

1/420
What is prob of sequence msm when three letters picked without replacement from {s: 8, m: 5, g: 3}?

1/21
What is prob of sequence vnc when three letters picked without replacement from nvncnnnncnnnnnnc?

3/280
Three letters picked without replacement from sssssuuusubsuususss.

77/5814
What is prob of sequence hnn when three letters picked without replacement from {n: 5, h: 7, o: 8}?

7/342
Calculate prob of sequence rvs when three letters picked without replacement from sqqggrqqrsgdvd.


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Eviscape OAuth has adopted OAuth 1.0a.

We have found XSRF bug with our Authentication mechanism.

Developers:Now you can register your application with "callback" and default "permission" parameters, they'll be override by "oauth_callback" and "perm".

You may also edit your existing applications and provide this parameters.

In other changes, We'r now only accepting "oauth_callback" while asking for request token.

Users:We have adopted "verifier" mechanism which means, if there is no callback then we'll display verification code on screen which you might needed for application which made request to access you account.

Use token and secret from above response and make an authorization call http://www.eviscape.com/oauth/authorize for write access(?perms=write) you can also make a request for read access only with your oauth token and secret which you obtained in step 3.

Finally If User approves, then You can exchange your oauth_token with access_token which you'll be using in making authenticated API calls.


Payday loans are short-term, small-sum, high-rate, unsecured personal loans that utilize a consumer's checking account (usually through electronic access but sometimes actual checks) for repayment of the amount borrowed.

That means paying off your cash advance in a timely manner is crucial to saving you money long term.

In other words, in the unlikely event that you're able to repay your loan before the due date, many payday lenders will impose an additional fee, which effectively negates any savings you might have otherwise obtained.

So the shock from these numbers is, we recognize the shock here because we are used to calculating interest rates on loans but not interest rates on anything else.

In most cases, once you meet the eligibility requirements , you should receive a quick credit decision.

Fast Payday Loans, Inc has several convenient neighborhood locations throughout Florida, so you are never far from the cash you need.

However, always assume that once you are approved you will receive the money in your account the next business day.

If you are in need of a new loan, and have a long history of bad debt associated with your name, the best place to start searching for information on the lenders who may be willing to entertain an application would be through specialist forums.

However, if you can't find a good loan from a LendKey partner, this tool could be helpful.

Once you received the cash you need, it's up to you to decide how to use it.

There are no usage restrictions with a cash loan.

Once you've built your credit above the 600 threshold, visit your local credit union to apply for a personal loan.

Some research backs that claim: A Federal Deposit Insurance Corporation study of payday lending's profitability concluded that high delinquency rates and the overhead of running retail stores justified the industry's interest rates.

Critics say that governments at the federal and state levels are also to blame for allowing the payday practice to continue.


@MaxBlumenthal Nothing than worse than a pathetic self loathing jew


Break that fucking jew


how long until we find out it was another jew


@bellewriter @Inquirer2676 @gabby_werner Only if he's a Jew, apparently


@marklevinshow Did u like Omar? She hates you jew


@lulutifah Labour again standing proud for the Muzzie but not the Jew!


@AdamFriedland You.. asshole.. are one fugly Jew: https://t.co/BrGjnv5IZH


@Zain_MB Loooll the jew cunts rich


@FleeceRodgers @PlayoffSkinz @Supr3me_Jay Your still my favorite Jew


Several descriptors of biofilms were analyzed before and after each step .


Outside of the ankle region , little or no evidence was seen for expansion of the synovial membrane .


However , no functional assay has yet been developed to demonstrate whether or not the two half - transporters function as homo - or heterodimers and whether they selectively pump sterols .

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-MAT O


Improving correlated SERS measurements with scanning electron microscopy : an assessment of the problem arising from the deposition of amorphous carbon .

O O O O O O O O O O O O O O O O O O O O B-MAT O


Recent developments in the study of opioid receptors .


These tachykinins , in turn , initiate a micturition reflex by stimulating NK1 and NK2 receptors .


Mutations in Crx represent one of a collection of gene mutations that lead to an outer segment formation defect .


These findings led us to hypothesise that ADAM11 is an integrin binder that plays an important role in the nervous system , as do ADAM22 and ADAM23 .

O O O O O O O O O O O O O O O O O O O O O O O O O O O O


Strategies for the selection of catalytic antibodies against organophosphorus nerve agents .


I gave you my love
Though crystalized
I sent you a rose with nevermore
So many years
So many hours
And only thistles on my shore
For all that its worth
The blood on my hands
Is the blood of divinities
And all that is lost
Sound or unsound
Only bonds between you and me
If I go will you follow
Me through the cracks and hollows
And I would be your Cain
If you would be here now
If I go will you follow
Me through the cracks and hollows
And I would be your Cain
If you would be here now
The Mother-of-Pearl
Handcrafted by God
Youre the tower they built to reach the sky
A White Falcon beauty
My mark on your skin
Follow me down the stairs when we die
Your soul is in heaven
Your body in hell
It doesnt matter much to me
In the night of the unborn
Sound or obscene
Only bonds between you and me
If I go will you follow
Me through the cracks and hollows
And I would be your Cain
If you would be here now
If I go will you follow
Me through the cracks and hollows
And I would be your Cain
If you would be here now
Blessed be our Lady Nuit
Guide us to Ra-Hoor-Khuit
In your night we find shelter
Before the Helter Skelter


Decoctions of Jimsonweed
Slimy trailing plants distil
Claustrophobia and blood mixed seed
Cursed downstairs against my will
Cobweb sticks to molten years
Cockroaches served with cream
I wipe the silver bullet tears
And with every tear a dream
With every tear a dream...
Honey tea, psilocybe larvae
Honeymoon, silver spoon
Psilocybe tea
Energy trickles with the tide
Masterminds and the suicide squad
Drink acid water by my side
Stake the saviour of their daily fraud
Overfilled toothpaste tubes
Sleepless and timeless faces
Drippety drop on sugarcubes
The one eyeds eye twinkles and gazes
Twinkles and gazes...
Honey tea, psilocybe larvae
Honeymoon, silver spoon
Psilocybe tea


Come down, slowly
Im waiting by your side
Come down, carefully
Im waiting by your side
Ill grab you when you fall
Down to the waking hours
Silent sweeps as golden corn
Down to the waking hours
How I wish that I could
Break into your dreams
Do I have the force I need
To break into your dreams
I hold you in my arms
Dimmed by scarlet morning red
I whisper in your ear
Do you dream of me?
Music: Johan Edlund, Waldemar Sorchyta


We could wander in the garden of Eden baby
We could do anything tonight, maybe
We could even touch the sky
If we just get up on our feet and try
We could wander in the garden of Eden baby
Will you settle for the bulls run
For the second best of fun
For the fire of a handgun
Burns brighter than the sun
Any colour you like as long as its black
You have anything if you just give it back
You could be a celebrity like me
It wont change anything as you will see
Any colour you like as long as its black


Blame my cloven hooves
If I sink what does it prove
Ill always will be your prey
Blame my crooked cross
Say Im your bitter loss
The winds of hell are blowing your way

Carry your cross and Ill carry mine
Dig your own hole and youll be fine
Build your own tower until heavens devour
Your very last hour

Blame it on Hells fire
And on my desires
The skies are crying blood
Give me all your lies
And blame the lord of flies
The face of evil is the face of God

Carry your cross and Ill carry mine
Dig your own hole and youll be fine
Build your own tower until heavens devour
Your very last hour
Carry your cross and Ill carry mine
Dig your own hole and youll be fine
Build your own tower until heavens devour
Your very last hour


Alone I sit, I wonder why
You dream of love and so do I
But in your sleep you cannot see
This pain which is always haunting me
What I need Ill never feel
This world is for me unreal
So I drink to darkness with a candle lit
And throught the whole night alone I sit
The Sleeping Beauty
She stops the bleeding
She stops the bledding in my soul
She is fresh air in this stinking world
The more I drink, the more I see
That suicide could be the key
To the place called paradise
Where pain not dwells, not hate nor lies
But if I look beyond all this
I reckon something I would surely miss
Because in my dream I rule my life
And the sleeping beauty is my wife
The Sleeping Beauty
She stops the bleeding
She stops the bleeding in my dreams
She is fresh air in this stinking world


Robin Goodfellow
Dianae, my muse
Morpheus in my heart
Your sand in my veins
Its a deeper kind of slumber
What is universe anyway
But a pouch of silver coins
The intense breathing
Of a dying animal
A foreboding of afterlife
Master keys in oaken chest
The somewhere is mine
And from there Ill continue
All I asked for was a little love
Meet me on the other side
Where as a rose I will wake
Though blind Ill follow every step you take
Dianae, my muse
Dianae, my solitude
Cease to exist, rise to exist no more
Its a deeper kind of slumber


Weve been soaked in acid
Always praised the downfall
With the sound of cadent wings
Its a wonder were standing tall
But in the truth of the morning glory
And the fear in our wishing well
Were on to another story
Its about time we all get out and vote for love
Its about time we all get out and vote for love
Its about time we all get out and vote for love
Its about time we all get out and vote for love
We are white zombies
Chained to our own demise
Decades of sleepwalking
No lights shining in out eyes
Weve painted all doors bible black
Wir haben niemals kampflos aufgegeben
If theres light well claim it back
Its about time we all get out and vote for love
Its about time we all get out and vote for love
Its about time we all get out and vote for love
Its about time we all get out and vote for love
Time to claim it back
Time to claim it back


His evolution will also come to global in time.


As the molecules move away from the skin, they will take the excess heat with them.


Well be featuring stories and videos this week on some of the most intriguing


Besides,it shall bear the cost of conducting matches,the judge ruled


I cant believe it How handsome  i cant take my eyes of him


dsheacreate I like horses but Im not going to buy any online  mulegirl njustenoughresearch abookapart httpstcoYSTLfBQ3he


Draft BPA best player available in the first five to seven rounds depending on your settings.


rubycassettes HI HOW ARE YOU


Some will include all viewers above the age of four,others will focus on 25plus and some others on 35plus audience


Will anyone study Shakespeare like we do?


the Intergovernmental Panel on Climate Change is misleading humanity about climate change and sea levels, and that in fact a new solar-driven cooling period is not far off.

Over the six years studied, the actual temperature rise was near the top end of the range given by IPCC's 2001 projection, and the actual sea level rise was above the top of the range of the IPCC projection.


Reef material is calcium carbonate, which contains 44 per cent carbon dioxide.

Under these conditions calcium carbonate decomposes to produce carbon dioxide which, along with other gases, give rise to explosive volcanic eruptions.


A windmill could spin until it falls apart and never generate as much energy as was invested in building it.

A wind turbine is a windmill-like structure specifically developed to generate electricity.


The Alaskan tundra is warming so quickly it has become a net emitter of carbon dioxide ahead of schedule, a new study finds

Humans have ways to cut greenhouse gas emissions and avoid the consequences of global warming, a major climate report concluded.


They were going to be gone by now, but now they're setting records

The amount of surface warming in West Antarctica, while large, has not led to appreciable melting at the surface, and is not directly affecting the West Antarctic Ice Sheet's contribution to sea level.


There is long-term correlation between CO2 and global temperature; other effects are short-term.

During the glacial cycles, there was a high correlation between CO 2 concentrations and temperatures.


Sea-level rise does not seem to depend on ocean temperature, and certainly not on CO2

This acceleration is due mostly to human-caused global warming, which is driving thermal expansion of seawater and the melting of land-based ice sheets and glaciers.


The fact that there's a Highway to Hell and only a Stairway to Heaven says a lot about anticipated traffic numbers...

Dopotutto, il fatto che si dica: esista un'autostrada per l'inferno e solo una scala per il paradiso... la dice lunga su quanto ci dobbiamo purtroppo attendere...


You will need help from your doctor and other members of your health care team, so that your treatment for Gestational Diabetes can be modified as needed.

Avrete bisogno di aiuto dal medico, infermiere o altra assistenza sanitaria in modo che il trattamento per il diabete gestazionale possa essere modificato in base alle esigenze.


shivsaina  nam mulla  saina  rakh  hijra  uddhav thackeray


there are some yahodi daboo like imran chore zakat khore


can you please stop pinning a fan everytime bro  what you need attention  ki log aakar gaali de  usne tera naam likha ho post me  usne tere idol sid ko kuch bola ho   ajeeb chutiya ho yaar poke krna h 24ghante tum chutiyo ko  show ko show ki tarah dekho bc


Context: In the First World War, Devonport was the headquarters of Western Approaches Command until 1941 and Sunderland flying boats were operated by the Royal Australian Air Force. It was an important embarkation point for US troops for D-Day. The city was heavily bombed by the Luftwaffe, in a series of 59 raids known as the Plymouth Blitz. Although the dockyards were the principal targets, much of the city centre and over 3,700 houses were completely destroyed and more than 1,000 civilians lost their lives. This was largely due to Plymouth's status as a major port Charles Church was hit by incendiary bombs and partially destroyed in 1941 during the Blitz, but has not been demolished, as it is now an official permanent monument to the bombing of Plymouth during World War II.

Question: What city was heavily bombed by the Luftwaffe?


Context: During the 1930s, parts of the state began suffering the consequences of poor farming practices, extended drought and high winds. Known as the Dust Bowl, areas of Kansas, Texas, New Mexico and northwestern Oklahoma were hampered by long periods of little rainfall and abnormally high temperatures, sending thousands of farmers into poverty and forcing them to relocate to more fertile areas of the western United States. Over a twenty-year period ending in 1950, the state saw its only historical decline in population, dropping 6.9 percent as impoverished families migrated out of the state after the Dust Bowl.

Question: What is it called to work the land and plant crops?


Context: About five percent of the population are of full-blooded indigenous descent, but upwards to eighty percent more or the majority of Hondurans are mestizo or part-indigenous with European admixture, and about ten percent are of indigenous or African descent. The main concentration of indigenous in Honduras are in the rural westernmost areas facing Guatemala and to the Caribbean Sea coastline, as well on the Nicaraguan border. The majority of indigenous people are Lencas, Miskitos to the east, Mayans, Pech, Sumos, and Tolupan.

Question: Which group represents a larger percentage of the population, those with full-blooded indigenous descent or those that are mestizo or part-indigenous with European admixture?


Context: The Monument in the City of London provides views of the surrounding area while commemorating the Great Fire of London, which originated nearby. Marble Arch and Wellington Arch, at the north and south ends of Park Lane respectively, have royal connections, as do the Albert Memorial and Royal Albert Hall in Kensington. Nelson's Column is a nationally recognised monument in Trafalgar Square, one of the focal points of central London. Older buildings are mainly brick built, most commonly the yellow London stock brick or a warm orange-red variety, often decorated with carvings and white plaster mouldings.

Question: what is the last area mentioned?


There comes a time when we heed a certain call
When the world must come together as one
There are people dying
Oh when its time to lend a hand to life
The greatest gift of all
We cant go on pretending day by day
That someone, somewhere will soon make a change
We are all a part of Gods great big family
And the truth, you know
Love is all we need
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me
Send them your heart so theyll know that someone cares
And their lives will be stronger and free
As God has shown us by turning stone to bread
So we all must lend a helping hand
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me
When youre down and out, there seems no hope at all
But if you just believe, theres no way we can fall
Well, well, well
Let us realize, oh, that a change can only come
When we stand together as one
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me
Alright let me hear you
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a brighter day
Just you and me
Come on yall let me hear you
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me, yeah, yeah
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me
Thank you
We are the world, we are the children
We are the ones who make a brighter day
So lets start giving
Theres a choice were making
Were saving our own lives
Its true well make a better day
Just you and me


How many roads must a man walk down
Before you call him a man?
How many seas must the white dove sail
Before she sleeps in the sand?
Yes, and how many times must the cannonballs fly
Before theyre forever banned?
The answer, my friend, is blowin in the wind
The answer is blowin in the wind
Yes, and how many years can a mountain exist
Fore it is washed to the sea?
Yes, and how many years can some people exist
Before theyre allowed to be free?
Yes, and how many times can a man turn his head
And pretend that he just doesnt see?
The answer, my friend, is blowin in the wind
The answer is blowin in the wind
Yes, and how many times must a man look up
Before he can see the sky?
Yes, and how many ears must one man have
Before he can hear people cry?
Yes, and how many deaths will it take till he knows
That too many people have died?
The answer, my friend, is blowin in the wind
The answer is blowin in the wind


When the rain is blowing in your face
And the whole world is on your case
I could offer you a warm embrace
To make you feel my love
When the evening shadows and the stars appear
And there is no one there to dry your tears
I could hold you for a million years
To make you feel my love
I know you havent made your mind up yet
But I will never do you wrong
Ive known it from the moment that we met
No doubt in my mind where you belong
Id go hungry, Id go black and blue
Id go crawling down the avenue
Know theres nothing that I wouldnt do
To make you feel my love
The storms are raging on the rollin sea
And on the highway of regret
The winds of change are blowing wild and free
You aint seen nothing like me yet
I could make you happy, make your dreams come true
Nothing that I wouldnt do
Go to the ends of the earth for you
To make you feel my love
To make you feel my love


Come gather round people, wherever you roam
And admit that the waters around you have grown
And accept it that soon youll be drenched to the bone
If your time to you is worth saving
Then you better start swimmin or youll sink like a stone
For the times, they are a-changin
Come writers and critics who prophesize with your pen
And keep your eyes wide, the chance wont come again
And dont speak too soon, for the wheels still in spin
And theres no tellin who that its namin
For the loser now will be later to win
For the times, they are a-changin
Come senators, congressmen, please heed the call
Dont stand in the doorway, dont block up the hall
For he that gets hurt will be he who has stalled
The battle outside ragin
Will soon shake your windows and rattle your walls
For the times, they are a-changin
Come mothers and fathers throughout the land
And dont criticize what you cant understand
Your sons and your daughters are beyond your command
Your old road is rapidly aging
Please get out of the new one if you cant lend your hand
For the times, they are a-changin
The line, it is drawn, the curse, it is cast
The slow one now will later be fast
As the present now will later be past
The order is rapidly fading
And the first one now will later be last
For the times, they are a-changin


There must be some way out of here
Said the joker to the thief
Theres too much confusion
I cant get no relief
Businessmen, they drink my wine
Plowmen dig my earth
None of them along the line
Know what any of it is worth
No reason to get excited
The thief, he kindly spoke
There are many here among us
Who feel that life is but a joke
But you and I, weve been through that
And this is not our fate
So let us not talk falsely now
The hour is getting late
All along the watchtower
Princes kept the view
While all the women came and went
Barefoot servants too
Outside, in the distance
A wildcat did growl
Two riders were approaching
The wind began to howl


Ooh, ooh
Hey
Mama, take this badge from me
I cant use it anymore
Its gettin dark, too dark to see
Feels like Im knockin on heavens door
Knock-knock-knockin on heavens door, hey, hey, hey hey yeah
Knock-knock-knockin on heavens door, ooh
Knock-knock-knockin on heavens door, ooh-oh yeah
Knock-knock-knockin on heavens door, ayy hey yeah
Ooh-oh yeah, oh yeah, aw
Mama, put my guns in the ground
I cant shoot them anymore
That cold black cloud is comin down
Feels like Im knockin on heavens door
Knock-knock-knockin on heavens door, hey, hey, hey hey yeah
Knock-knock-knockin on heavens door
Knock-knock-knockin on heavens door, ooh yeah
Knock-knock-knockin on heavens door, ayy hey yeah
Ooh
You just better start sniffing your own rank subjugation, Jack
Because its just you against your tattered libido
The bank and the mortician, forever, man
And it wouldnt be luck if you could get out of life alive
Knock-knock-knockin on heavens door, hey, hey, hey hey yeah
Knock-knock-knockin on heavens door
Knock-knock-knockin on heavens door, ooh yeah
Knock-knock-knockin on heavens door
Knock-knock-knockin on heavens door, ooh, no, no, no, woah
Knock-knock-knockin on heavens door
Knock-knock-knockin on heavens door, no, no, no, woah, no
Knock-knock-knockin on heavens door, woah, woah, woah, yeah
Knock-knock-knockin on heavens door
Knock-knock-knockin on heavens door, ooh yeah
Knock-knock-knockin on heavens door
Knock-knock-knockin on heavens door, woah, woah, woah
Woah, woah, yeah, oh


There must be some kind of way out of here
Said the joker to the thief
Theres too much confusion
I cant get no relief
Businessmen they drink my wine
Plowmen dig my earth
None will level on the line
Nobody offered his word
Hey!
No reason to get excited
The thief, he kindly spoke
There are many here among us
Who feel that life is but a joke
But, uh, but you and I, weve been through that
And this is not our fate
So let us stop talkin falsely now
The hours getting late
Hey!
Hey!
All along the watchtower
Princes kept the view
While all the women came and went
Barefoot servants too
Well, uh, outside in the cold distance
A wildcat did growl
Two riders were approaching
And the wind began to howl
Hey!
All along the watchtower
All along the watchtower


I don't have much to add to that debate here, other than to observe that it's very rare that data is unambiguous about important societal shifts before those shifts actually occur. When the data is unambiguous, it is almost always too late to do anything. The only sure sign of having a heart attack is, well, having a heart attack. Similarly, the only sure sign of a democratic collapse is, well, a democratic collapse. And whatever you think of the data analysis, there is also a mounting series of actual real-world election results that are hard to explain if support for liberal democracy is thriving. In deciding how seriously to take these findings, it's also worth asking what we would do differently if we took Foa and Mounk's findings seriously. How would we collectively respond? And what would be the consequences? For one, we'd probably invest in a lot more civic education, so that the next generation learns the basics of liberal democracy and understands why it's a better system than authoritarian rule. This seems like a good idea regardless.


Similarly, we might collectively invest considerable resources in making a strong public case for liberal democracy. We might also try to figure out ways to make our public institutions do more outreach to citizens to make sure they feel engaged in their democracy, and think hard about building up intermediary institutions that help people feel as though their voices are represented and taken seriously. Again, these seem like things we should be doing regardless, like reducing stress or improving the health of our diets. In my heart attack parable, if the doctor had told you that the only way to prevent a future heart attack would be to give up your job and your social life and spend the next year on strict bed rest eating only kale and chia seed salads, you might want to be a little more certain that you really were at high risk for a heart attack. After all, taking the risk seriously would impose a heavy cost on you. Other recent crises offer some examples of cases where key decision-makers did ignore warning signs, because taking those signs seriously would have imposed significant costs on them. For example, in the housing bubble of the mid-2000s, warnings were ignored because the financial industry had staked considerable investments and product lines on the myth that housing values would go up forever. To admit that housing was overvalued and that securitized mortgages were riskier than advertised would have cost investment banks dearly. But eventually, reality caught up with them, and the resulting damage was far worse than it would have been if we had paid attention to the early warning signs. Similarly, many carbon-intensive industries and fossil fuel producers pushed back on findings of climate change because taking those findings seriously would force significant changes in their industries.


As a result, these industries funded doubt and uncertainty. The problem has since gotten much worse, and it has become harder to take effective action. The early scientists may have been alarmist. But we'd be in much better shape if we had listened to them. I would be more comforted if I could be certain that Voeten is right and Foa and Mounk are wrong. Maybe there is indeed nothing to worry about. But given the risks, as well as the recent string of election results, I'd rather err on the side of caution. Like the threat of a heart attack, the threat of autocracy or military rule replacing liberal democracy is pretty serious, and very difficult to recover from. I don't want to take a chance. Especially when the preventive medicine consists of things we should probably be doing anyway.


The highest-paid player on all 32 NFL teams


In 2012 , Italian jazz trumpeter Enrico Rava released a version on his tribute album Rava on the Dance Floor .

The annual Hull Jazz Festival takes place around the Marina area for a week at the beginning of August .


Other parks include Canal Park , a family park located on the west bank of the Rakh Branch Canal .

The Frankwell flood defences were completed in 2003 , along with the new offices of the borough council .


Most freshman residence halls are located near the Washington Square area .

All freshmen are housed in one of 14 residences on East Campus .


In April 2008 the Parents ' Choice Foundation awarded The Dragonfly Races a Silver Medallion .

As Miss Chief , Ripley performed magic tricks and painted faces at children 's parties .


There have been said to be more reasons , other than gender roles , as to why there is a difference in the housework performed by men and women .

You must not leave a vacuum , " Rhodes instructed . "


No wake boating allowed available at Lake Cunningham , Standing Bear Lake or Zorinsky Lake ; however , these lakes offer opportunities for sailing , fishing and pleasure boating .

Sea Scouting is the program for young men and women ages 14 through 21 focused on nautical activities .


At the Closing Ceremony athletes entered in a less formal style , led by the flag bearers of all the competing nations .

In 2009 , Hong Kong hosted the 5th East Asian Games , in which nine national teams competed .


The two were married in fall 2009 and had their first child , daughter Hartley , in December 2010 .

Henry lives in Austin , Texas with his wife Jana , son Jacob , and daughter Joanna .


In 2000 , the Festival reached an agreement with Cedille Records to record the Grant Park Orchestra .

For the opening theme , a trumpet solo accompanied by an orchestra was used .


Ive been reading books of old
The legends and the myths
Achilles and his gold
Hercules and his gifts
Spider-Mans control
And Batman with his fists
And clearly I dont see myself upon that list
But she said, where dyou wanna go?
How much you wanna risk?
Im not looking for somebody
With some superhuman gifts
Some superhero
Some fairytale bliss
Just something I can turn to
Somebody I can kiss
I want something just like this
Doo-doo-doo, doo-doo-doo
Doo-doo-doo, doo, doo
Doo-doo-doo, doo-doo-doo
Oh, I want something just like this
Doo-doo-doo, doo-doo-doo
Doo-doo-doo, doo, doo
Doo-doo-doo, doo-doo-doo
Oh, I want something just like this
I want something just like this
Ive been reading books of old
The legends and the myths
The testaments they told
The moon and its eclipse
And Superman unrolls
A suit before he lifts
But Im not the kind of person that it fits
She said, where dyou wanna go?
How much you wanna risk?
Im not looking for somebody
With some superhuman gifts
Some superhero
Some fairytale bliss
Just something I can turn to
Somebody I can miss
I want something just like this
I want something just like this
Oh, I want something just like this
Doo-doo-doo, doo-doo-doo
Doo-doo-doo, doo, doo
Doo-doo-doo, doo-doo-doo
Oh, I want something just like this
Doo-doo-doo, doo-doo-doo
Doo-doo-doo, doo, doo
Doo-doo-doo, doo-doo-doo
Where dyou wanna go?
How much you wanna risk?
Im not looking for somebody
With some superhuman gifts
Some superhero
Some fairytale bliss
Just something I can turn to
Somebody I can kiss
I want something just like this
Oh, I want something just like this
Oh, I want something just like this
Oh, I want something just like this


Come up to meet you, tell you Im sorry
You dont know how lovely you are
I had to find you, tell you I need you
Tell you I set you apart
Tell me your secrets, and ask me your questions
Oh, lets go back to the start
Running in circles, coming up tails
Heads on a science apart
Nobody said it was easy
Its such a shame for us to part
Nobody said it was easy
No one ever said it would be this hard
Oh, take me back to the start
I was just guessing at numbers and figures
Pulling the puzzles apart
Questions of science, science and progress
Do not speak as loud as my heart
Tell me you love me, come back and haunt me
Oh, and I rush to the start
Running in circles, chasing our tails
Coming back as we are
Nobody said it was easy
Oh, its such a shame for us to part
Nobody said it was easy
No one ever said it would be so hard
Im going back to the start
Oh-ooh ooh-ooh-ooh-ooh
Ah-ooh ooh-ooh-ooh-ooh
Oh-ooh ooh-ooh-ooh-ooh
Oh-ooh ooh-ooh-ooh-ooh


I used to rule the world
Seas would rise when I gave the word
Now in the morning, I sleep alone
Sweep the streets I used to own
I used to roll the dice
Feel the fear in my enemys eyes
Listen as the crowd would sing
Now the old King is dead, long live the King
One minute I held the key
Next the walls were closed on me
And I discovered that my castles stand
Upon pillars of salt and pillars of sand
I hear Jerusalem bells are ringing
Roman Cavalry choirs are singing
Be my mirror, my sword, and shield
My missionaries in a foreign field
For some reason I cant explain
Once youd gone, there was never
Never an honest word
And that was when I ruled the world
It was the wicked and wild wind
Blew down the doors to let me in
Shattered windows and the sound of drums
People couldnt believe what Id become
Revolutionaries wait
For my head on a silver plate
Just a puppet on a lonely string
Aw, who would ever want to be king?
I hear Jerusalem bells are ringing
Roman Cavalry choirs are singing
Be my mirror, my sword, and shield
My missionaries in a foreign field
For some reason I cant explain
I know Saint Peter wont call my name
Never an honest word
But that was when I ruled the world
Oh-oh-woah, oh-oh, oh
Oh-oh-woah, oh-oh, oh
Oh-oh-woah, oh-oh, oh
Oh-oh-woah, oh-oh, oh
I hear Jerusalem bells are ringing
Roman Cavalry choirs are singing
Be my mirror, my sword and shield
My missionaries in a foreign field
For some reason I cant explain
I know Saint Peter wont call my name
Never an honest word
But that was when I ruled the world
Mmm, mmm, mmm, mmm
Mmm, mmm, mmm, mmm
Mmm, mmm


When you try your best, but you dont succeed
When you get what you want, but not what you need
When you feel so tired, but you cant sleep
Stuck in reverse
And the tears come streaming down your face
When you lose something you cant replace
When you love someone, but it goes to waste
Could it be worse?
Lights will guide you home
And ignite your bones
And I will try to fix you
And high up above or down below
When youre too in love to let it go
But if you never try, youll never know
Just what youre worth
Lights will guide you home
And ignite your bones
And I will try to fix you
Tears stream down your face
When you lose something you cannot replace
Tears stream down your face, and I
Tears stream down your face
I promise you I will learn from my mistakes
Tears stream down your face, and I
Lights will guide you home
And ignite your bones
And I will try to fix you


Look at the stars
Look how they shine for you
And everything you do
Yeah, they were all yellow
I came along
I wrote a song for you
And all the things you do
And it was called Yellow
So then I took my turn
Oh, what a thing to have done
And it was all yellow
 Your skin, oh yeah, your skin and bones
 Turn into something beautiful
 You know, you know I love you so
You know I love you so
I swam across
I jumped across for you
Oh, what a thing to do
Cause you were all yellow
I drew a line
I drew a line for you
Oh, what a thing to do
And it was all yellow
 Your skin, oh yeah, your skin and bones
 Turn into something beautiful
 And you know
For you, Id bleed myself dry
For you, Id bleed myself dry
Its true, look how they shine for you
Look how they shine for you
Look how they shine for
Look how they shine for you
Look how they shine for you
Look how they shine
Look at the stars
Look how they shine for you
And all the things that you do


Cause youre a sky, cause youre a sky full of stars
Im gonna give you my heart
Cause youre a sky, cause youre a sky full of stars
Cause you light up the path
I dont care, go on and tear me apart
I dont care if you do, ooh-ooh, ooh
Cause in a sky, cause in a sky full of stars
I think I saw you ooh-ooh-ooh, ooh-ooh-ooh
Cause youre a sky, cause youre a sky full of stars
I wanna die in your arms, oh-oh-oh, oh-oh
Cause you get lighter the more it gets dark
Im gonna give you my heart, oh
I dont care, go on and tear me apart
I dont care if you do, ooh-ooh, ooh
Cause in a sky, cause in a sky full of stars
I think I see you ooh-ooh-ooh, ooh-ooh-ooh
I think I see you ooh-ooh-ooh, ooh-ooh-ooh
Cause youre a sky, youre a sky full of stars
Such a heavenly view
Youre such a heavenly view


Turn your magic on
Umi shed say
Everything you wants a dream away
And we are legends, every day
Thats what she told me
Turn your magic on, to me shed say
Everything you wants a dream away
Under this pressure, under this weight
We are diamonds
Now I feel my heart beating
I feel my heart underneath my skin
And I feel my heart beating
Oh, you make me feel
Like Im alive again
Alive again
Oh, you make me feel
Like Im alive again
Said I cant go on, not in this way
Im a dream that died by light of day
Gonna hold up half the sky and say
Only I own me
Now I feel my heart beating
I feel my heart underneath my skin
Oh, I can feel my heart beating
Cause you make me feel
Like Im alive again
Alive again
Oh, you make me feel
Like Im alive again
Turn your magic on, Umi shed say
Everything you wants a dream away
Under this pressure, under this weight
We are diamonds taking shape
We are diamonds taking shape
If weve only got this life
This adventure, oh then I
And if weve only got this life
Youll get me through
And if weve only got this life
In this adventure, oh then I
Want to share it with you
With you, with you
Yeah, I do


Ooh-ooh-ooh, ooh-ooh-ooh, ooh-ooh-ooh
Ooh-ooh-ooh, ooh-ooh-ooh, ooh-ooh-ooh
When she was just a girl
She expected the world
But it flew away from her reach
So she ran away in her sleep
And dreamed of para-para-paradise
Para-para-paradise
Para-para-paradise
Every time she closed her eyes
Ooh-ooh-ooh, ooh-ooh-ooh, ooh-ooh-ooh
Ooh-ooh-ooh, ooh-ooh-ooh, ooh-ooh-ooh
When she was just a girl
She expected the world
But it flew away from her reach
And the bullets catch in her teeth
Life goes on, it gets so heavy
The wheel breaks the butterfly
Every tear, a waterfall
In the night, the stormy night, shed close her eyes
In the night, the stormy night, away shed fly
And dream of para-para-paradise
Para-para-paradise
Para-para-paradise
Oh, oh-oh, oh-oh, oh-oh-oh
Shed dream of para-para-paradise
Para-para-paradise
Para-para-paradise
Oh, oh-oh, oh-oh, oh-oh-oh
La, la-la, la-la-la
La, la-la, la-la-la
La, la-la, la-la-la, la-la
So lying underneath those stormy skies
She said, Oh, oh-oh-oh-oh I know the sun must set to rise
This could be para-para-paradise
Para-para-paradise
This could be para-para-paradise
Oh, oh-oh, oh-oh, oh-oh-oh
This could be para-para-paradise
Para-para-paradise
This could be para-para-paradise
Oh, oh-oh, oh-oh, oh-oh-oh
This could be para-para-paradise
This could be para-para-paradise
This could be para-para-paradise
Oh-oh-oh-oh-oh oh-oh-oh
Ooh-ooh-ooh, ooh-ooh-ooh, ooh-ooh-ooh
Ooh-ooh-ooh, ooh-ooh-ooh, ooh-ooh-ooh
Ooh-ooh-ooh, ooh-ooh-ooh, ooh-ooh-ooh
Ooh-ooh-ooh, ooh-ooh-ooh...


Mrs. John Bradley (Florence Briggs Thayer) Cumings


Mrs. Jacques Heath (Lily May Peel) Futrelle


Mrs. Oscar W (Elisabeth Vilhelmina Berg) Johnson


Marcos stayed at Hickam Air Force Base from Feb. 26 to March 24, 1986, incurring housing costs of $65,879. That represented room charges in the Visiting Officers Quarters, $16,020; loss of revenue for rooms blocked and unused for security reasons, $11,770; additional payroll, $6,922; supplies (diapers, shampoo, etc.) and food and beverages, $7,813; long-distance phone charges, $19,971; repairs and miscellaneous charges, $2,383; and future State Department support, $1,000.


According to the De Lima, most of the fake news now spreading over the social media is being shared by pro-Duterte pages and websites.


The BIFF maintains a major camp in Dasikil, which Army soldiers captured early this month as part of an all-out offensive against the groups that fought the police commandos in Mamasapano. Bomb-making materials were seized in the camp.


The Skyway Stage 3 project will connect the North Luzon Expressway (NLEx) and South Luzon Expressway (SLEx).


He will face Pablo Cuevas in the last 32, after British number one Kyle Edmund retired from their second-round match with a left knee injury while trailing the Uruguayan 7-6 (7/3), 6-3, 2-1.


Authorities said social distancing was maintained while nearly 500,000 people had been evacuated. But testimonies suggested this often was not possible.


Youth Organization conducts a consultation for Comprehensive Mental Health Response during the time of COVID-19


Q:

Intel MKL - Difference between mkl_intel_lp64 and mkl_gf_lp64

I am currently trying to link a program against the Intel MKL 11.0 library instead of using NetLIB or OpenBLAS.

Doing this I recognized the following error which I can not explain to my self at the moment.

Consider the following C code example computing a complex scalar product using zdotc:
#include <stdio.h>
#include <stdlib.h>
#include <complex.h>
double complex zdotc_(int *n, double complex *X, int *incx, double complex *Y, int *INCY );
int main ( ) {
    int n = 5;
    int incx = 1, incy = 1;
    double complex x[5] = {1,I,2,2+I,3};
    double complex y[5] = {I,3,I*3, 2+2*I, 9};
    double complex ret;
    ret = zdotc_(&n,x,&incx,y,&incy);
    printf("n   = %d\n", n);
    printf("ret = %lg + %lgi\n", creal(ret), cimag(ret));
    return 0;
}

I compiled this example using the command line flags given by the MKL Advisor.

I select "GNU C/C++, 32 Bit Integer, Dynamic Linking, GNU OpenMP".

The resulting command line is:
gcc zdotc_test.c -o zdot_mkl_gcc -O2  -L$MKLROOT/lib/intel64 -lmkl_intel_lp64 -lmkl_gnu_thread -lmkl_core -ldl -lpthread -lm  -fopenmp -m64 -I$MKLROOT/include

The output of this program is:
n   = 0
ret = 0 + 1.07933e+21i

which is obviously wrong and especially why is n altered?

If I select GNU Fortran instead of GNU C/C++, I have to replace -lmkl_intel_lp64 by -lmkl_gf_lp64 and then the correct output
n   = 5
ret = 33 + 6i

is produced.

So my question is: where are the detailed differences between those to interfaces and why does the first one produced this error?

A:

The difference has to do with the calling convention (ABI) differences.

ZDOTC is a problematic function because it returns a double complex, which is usually considered a struct rather than a "simple" data type.

Thus, it can either be returned on the stack as a return value, or by reference as an implicit first argument to the "C" style function.

I am guessing that what you are seeing here is that in the _intel_ case, it expects the return value to be an implicit first argument, so it returns the value and ends up modifying n, and the return value is then just completely wrong.

In that case the correct declaration is
void zdotc_(double complex *retval, int *n, double complex *X, int *incx, double complex *Y, int *INCY );

It's stupid stuff like this that makes me implement everything in C++ if possible.

In particular, I tend to implement BLAS level 1 in C++, where performance is limited by memory bandwidth anyways.

For BLAS levels 2 and 3, I will call actual BLAS, which does not have functions with this problem.

I believe I've seen benchmarks before comparing naive dot product implementations with optimized BLAS, and if you use __restrict type keywords, most optimizing compilers will produce code that's as fast as the optimized BLAS.

My own version is located here, where you would need the corresponding source file to provide forwarding of higher level BLAS, located here.

I would refer you to Eigen, but my code is slightly easier to port to C99 since it's less heavily templated.


import React from "react";
import { useNavigation } from "react-navi";
import memoizeOne from "memoize-one";
import { Block } from "baseui/block";
import { Navigation } from "baseui/side-navigation";
import { useCurrentRoute } from "react-navi";
import { toHref, toPermalink } from "../lib/helper";
import { toNavigation, filterNavigation } from "snowboard-theme-helper";

const toNavigationMemo = memoizeOne(toNavigation);

export default function ({ title, groups, resources, descriptionToc }) {
  const items = toNavigationMemo({
    title,
    groups,
    resources,
    toc: descriptionToc,
  });

  return <FilteredNavigation items={items} />;
}

function mapItem(item) {
  return {
    title: item.title,
    itemId: toHref(item.permalink),
    subNav: item.children.map((subitem) => mapItem(subitem)),
  };
}

function FilteredNavigation({ items }) {
  const route = useCurrentRoute();
  const navigation = useNavigation();
  const filteredItems = filterNavigation(
    toPermalink(route.url.pathname),
    items
  );

  return (
    <Block>
      <Navigation
        items={filteredItems}
        activeItemId={route.url.pathname}
        onChange={({ event, item }) => {
          event.preventDefault();
          navigation.navigate(item.itemId);
        }}
        mapItem={(item) => mapItem(item)}
        overrides={{
          NavItem: {
            style: ({ $active, $theme }) => {
              return {
                overflow: "hidden",
                whiteSpace: "nowrap",
                textOverflow: "ellipsis",
                paddingBottom: $theme.sizing.scale200,
                paddingTop: $theme.sizing.scale200,
              };
            },
          },
        }}
      />
    </Block>
  );
}


Trauma, blood loss and autologous blood transfusions induce a variety of changes in the reactivity of patients' immune systems.

In clinical studies the differentiation of these effects is difficult.

Association between autologous blood transfusion and postoperative infection is highly likely.

In surgical oncology blood transfusions are associated with poor prognosis, but probably this is more because of the circumstances that necessitate them.


HIV-1 protease is the target of the most effective anti-viral drugs for the treatment of HIV-1 infection.

All these drugs derive from successful structure-based design studies.

The enzyme cleaves the viral gag-pol polyprotein at least 10 unique sites and is essential for maturation of the virion and thus the spread of the virus.

Therefore, it has been a prime target for drug design research.

Unfortunately, the medical efficacy of the current drugs is proving to be short lived, as viable mutant variants of HIV-1 protease confer drug resistance.

Drug resistance is a subtle change in the balance of recognition events, between the relative affinity of the enzyme to bind inhibitors and its ability to bind and cleave substrates.

Since HIV-1 protease binds substrates and inhibitors at the same active site, a change that alters inhibitor binding also alters substrate binding.

We previously developed a structural rationale that explains how HIV protease recognizes its substrates and how drug resistant mutations occur within the active site of HIV protease, while still maintaining substrate recognition.

HIV protease recognizes a conserved asymmetric shape that the substrates adopt.

This shape is not discernable from the substrate's amino acid sequence, but only from their complexed three-dimensional (3D) structures.

We defined this shape, or consensus volume, as the substrate envelope".

This led us to the realization that most active-site drug-resistant mutations within HIV protease occur where the inhibitors protrude beyond the consensus substrate envelope and contact the protease.

Those protease residues are prime positions for drug resistance to occur, as they are more important for inhibitor binding than for substrate binding.

In this proposal, we elucidate the interdepence of substrate recognition and hypothesize that drug-induced co-evolution of HIV-1 protease and its polyprotein substrates occurs when the substrates extend beyond the consensus "substrate envelope" and that co-evolution occurs in an interdependent manner. [

unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]


/* Class object interface */

/* Revealing some structures (not for general use) */

#ifndef Py_CLASSOBJECT_H
#define Py_CLASSOBJECT_H
#ifdef __cplusplus
extern "C" {
#endif

typedef struct {
    PyObject_HEAD
    PyObject	*cl_bases;	/* A tuple of class objects */
    PyObject	*cl_dict;	/* A dictionary */
    PyObject	*cl_name;	/* A string */
    /* The following three are functions or NULL */
    PyObject	*cl_getattr;
    PyObject	*cl_setattr;
    PyObject	*cl_delattr;
    PyObject    *cl_weakreflist; /* List of weak references */
} PyClassObject;

typedef struct {
    PyObject_HEAD
    PyClassObject *in_class;	/* The class object */
    PyObject	  *in_dict;	/* A dictionary */
    PyObject	  *in_weakreflist; /* List of weak references */
} PyInstanceObject;

typedef struct {
    PyObject_HEAD
    PyObject *im_func;   /* The callable object implementing the method */
    PyObject *im_self;   /* The instance it is bound to, or NULL */
    PyObject *im_class;  /* The class that asked for the method */
    PyObject *im_weakreflist; /* List of weak references */
} PyMethodObject;

PyAPI_DATA(PyTypeObject) PyClass_Type, PyInstance_Type, PyMethod_Type;

#define PyClass_Check(op) ((op)->ob_type == &PyClass_Type)
#define PyInstance_Check(op) ((op)->ob_type == &PyInstance_Type)
#define PyMethod_Check(op) ((op)->ob_type == &PyMethod_Type)

PyAPI_FUNC(PyObject *) PyClass_New(PyObject *, PyObject *, PyObject *);
PyAPI_FUNC(PyObject *) PyInstance_New(PyObject *, PyObject *,
                                            PyObject *);
PyAPI_FUNC(PyObject *) PyInstance_NewRaw(PyObject *, PyObject *);
PyAPI_FUNC(PyObject *) PyMethod_New(PyObject *, PyObject *, PyObject *);

PyAPI_FUNC(PyObject *) PyMethod_Function(PyObject *);
PyAPI_FUNC(PyObject *) PyMethod_Self(PyObject *);
PyAPI_FUNC(PyObject *) PyMethod_Class(PyObject *);

/* Look up attribute with name (a string) on instance object pinst, using
 * only the instance and base class dicts.

 If a descriptor is found in
 * a class dict, the descriptor is returned without calling it.

 * Returns NULL if nothing found, else a borrowed reference to the
 * value associated with name in the dict in which name was found.

 * The point of this routine is that it never calls arbitrary Python
 * code, so is always "safe":  all it does is dict lookups.

 The function
 * can't fail, never sets an exception, and NULL is not an error (it just
 * means "not found").

 */
PyAPI_FUNC(PyObject *) _PyInstance_Lookup(PyObject *pinst, PyObject *name);

/* Macros for direct access to these values.

Type checks are *not*
   done, so use with care. */

#define PyMethod_GET_FUNCTION(meth) \
        (((PyMethodObject *)meth) -> im_func)
#define PyMethod_GET_SELF(meth) \
	(((PyMethodObject *)meth) -> im_self)
#define PyMethod_GET_CLASS(meth) \
	(((PyMethodObject *)meth) -> im_class)

PyAPI_FUNC(int) PyClass_IsSubclass(PyObject *, PyObject *);

PyAPI_FUNC(int) PyMethod_ClearFreeList(void);

#ifdef __cplusplus
}
#endif
#endif /* !


IO.Class
-- Copyright   :  (c) Andy Gill 2001,
--                (c) Oregon Graduate Institute of Science and Technology, 2001
-- License     :  BSD-style (see the file LICENSE)
--
-- Maintainer  :  R.Paterson@city.ac.uk
-- Stability   :  experimental
-- Portability :  portable
--
-- Class of monads based on @IO@.
-----------------------------------------------------------------------------

module Control.

IO.Class (
    MonadIO(..)
  ) where

-- | Monads in which 'IO' computations may be embedded.

-- Any monad built by applying a sequence of monad transformers to the
-- 'IO' monad will be an instance of this class.

--
-- Instances should satisfy the following laws, which state that 'liftIO'
-- is a transformer of monads:
--
-- * @'liftIO' . '

return' = 'return'@
--
-- * @'liftIO' (m >>= f) = 'liftIO' m >>= ('liftIO' .

f)@

class (Monad m) => MonadIO m where
    -- | Lift a computation from the 'IO' monad.

    liftIO :: IO a -> m a

-- | @since 4.9.0.0
instance MonadIO IO where
    liftIO = id


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Diesel model Winnie Harlow, who suffers from vitiligo, the same rare skin condition that singer Michael Jackson was diagnosed with, has been pictured enjoying a cozy night on the town with albino fashion star Shaun Ross. The pair attended a launch event for Popular magazine at Siren Studios in Hollywood, California, on Tuesday night, and were snapped holding hands while making their way into the venue. Winnie, 19, who was unveiled as one of the newest faces of fashion label Diesel earlier this year, was wearing a short and simple black and gold mini dress, which she accessorized with a pair of gold strappy heels. Scroll down for video . Looking cozy: Winnie Harlow, 19, who suffers from the same rare skin condition as Michael Jackson, was pictured hand-in-hand with albino model Shaun Ross on Tuesday night . Out on the town: The duo were attending the launch for Popular magazine at Hollywood venue Siren Studios . Skingraft black and gold dress . Get it from Pasar here . Visit site . This look is all types of yes. Winnie Harlow looks incredible in her leather tunic dress which features striking gold trims on the sleeves and hemline. The loose fit creates a flattering silhouette too. Winnie's dress is from LA-based fashion house Skingraft, and you can still buy it by clicking right to Paser's website now. It'll be your go-to party piece! It is however, slightly pricey coming in at $750, so if you want to add a golden standard to your style for less, why not check out these various finds below? We are particularly dazzled by this Mynt 1792 number at Nordstrom. A pair of strappy metallic heels will finish off your look to perfection! Choice's black and gold stamping dress . Visit site . Mynt 1792 color block dress at Nordstrom . Visit site . Maykool black and gold dress . Visit site . Dailylook fit and flare dress . Visit site . Meanwhile Shaun, 23, opted for a more low-key look, wearing an all-black ensemble, which he topped off with a unique tall baseball hat and a pair of leather sneaker-style boots. And while it appears to be the first time that the duo have been spotted enjoying an evening out together, it is likely not the first occasion that they have met. Both stars have made regular appearances on the catwalks at various Fashion Weeks, while Shaun has also starred in campaigns for the likes of Alexander McQueen and Givenchy. Coincidentally, the models also each had a helping hand from fellow fashion star Tyra Banks. Fashion stars: While Evan opted for an all-black ensemble, topped off with a bizarre baseball cap, Winnie wore a black and gold mini dress and strappy sandals . Rising stars: Both Shaun and Winnie have each achieved global recognition in the fashion indsutry, appearing in numerous high-profile fashion campaigns . Strut your stuff: Both Winnie (L), pictured at the Desigual fall/winter 2015 show, and Shaun (R), pictured on the catwalk in February, boast impressive runway credentials . Winnie, whose real name is Chantelle Brown-Young, was one of the contestants on Tyra's hit reality series America's Next Top Model, while Shaun made an appearance on the former model's eponymous talk show in 2009. Despite their cozy appearance, it's not thought that the two are dating - however Shaun did take the time to post a heartwarming message to the model on his Instagram account, just hours after the pair attended the Popular magazine event. Alongside an image of the two of them, Shaun wrote: 'So much fun last night @winnieharlow keep up the good work. From an original believer in you.' And it seems his sweet sentiments were reciprocated by Winnie, who posted a similar image on her own account, saying: 'Sweet nothings with my fly friend @shaundross'

Winnie, 19, was diagnosed with the rare condition when she was four-years-old .
Condition causes a lack of melanin which forms white patches on the skin .


(CNN)When Melissa Atkins Wardy, author of "Redefining Girly" and a passionate advocate for fighting gender stereotypes, heard from a frustrated mom on Facebook, she knew she needed to do something. So she shared the mom's story. In a blog post, Wardy told how the mom, Veronica of Richland, Washington, wanted to buy "Big Hero 6" fabric to make pillows for her two children. The problem? The fabric didn't include two of the heroes from the movie: the female characters, Honey Lemon and GoGo. So Veronica decided to send an email to Springs Creative, the company that makes the fabric, saying that as a woman and an engineer, she was offended. She got an answer from the company but it didn't help. Girl empowerment ads like GoldieBlox: Do they work? A licensing manager for Springs Creative responded that the company has found that boys don't want girl characters on their things. "Eeeww girls! Yuck! Haha," the licensing manager wrote. It will come as no surprise that Veronica was none too pleased to receive that response. "I was frustrated and disgusted that a manager, and a female manager too, would laugh off my initial contact with the company. It was unprofessional. So I responded," Veronica told CNN. She asked that we not use her last name, in order to maintain her privacy. In an email back to the company, Veronica wrote, "By eliminating the women in your fabric design, you are telling boys that it's OK to think girls are yucky, unworthy and less than a boy. "You are also telling girls they are unworthy, unwanted and that it's un-cool to be smart and confident." What happened next shows that parents, aided by social media outrage, may have more leverage to combat gender stereotyping in our culture than they realize. And the "Big Hero 6" example -- along with a similar recent one involving TOMS, the shoes retailer -- suggests that manufacturers may be finally getting it, too. First, the rest of the story about Springs Creative and the "Big Hero" fabric: After sharing Veronica's story with her readers and her 6,700 Twitter followers, Wardy encouraged people to give Springs Creative a piece of their mind. She also invited them to tweet their own stories with the hashtag #IncludeTheGirls. Women responded in droves, pointing out how Black Widow, the female character in the popular "Avengers" superhero movie franchise, is often excluded from merchandise and how cereal boxes rarely include female characters. "This sends the direct message to both boys and girls that females are forgettable, unimportant, undesirable. What a horrible thing to teach our children!" said Wardy, who is also the founder and chief executive officer of Pigtail Pals & Ballcap Buddies, a company that makes empowering clothing for boys and girls. "The prevailing theory is, 1. boys are the default audience, and 2. boys won't want an item with a girl on it," Wardy said. "Yet, I talk with thousands of parents every week who say otherwise." Why trying to make our kids happy can backfire . Those parents are clearly making their voices heard. Because not too long after Veronica received her initial response from Springs Creative, Wardy said she got a call from the company, asking her to post a statement from Springs Creative on her site. "It is sometimes difficult to hear negative feedback but the message was clear and we intend to act upon your message," the statement read. "Most importantly, Springs Creative does not condone sexism in any shape or form and does not design products to shine a negative light on females OR males." The company said it would be talking with Disney "immediately" about additional designs for "Big Hero 6" that would incorporate all the characters. "We would never intentionally offend any segment of the population. We are a strong company with positive morals and values and we respect and see both genders equally," said the statement. Springs Creative told CNN it would have no further comment. Veronica said she was surprised the company responded so quickly. "I do not believe this would have happened without the Pigtail Pals and Ballcap Buddies community also raising their voices." The real March Madness: When will women's teams get equal buzz? Around the same time, Wardy heard from another follower about an issue with TOMS and wrote about it on her site. On the normally progressive retailer's Web landing page for kids were photos that some parents felt played into gender stereotypes. One photo suggested "Playtime Approved" shoes for boys, and the other, this one on a pink background, included the caption "Little Ladies: adorn their feet for spring." "Really, TOMS? Girls are not ornaments we adorn. Girls play, too!" Wardy wrote on her Facebook page. Two hours later, Wardy received a comment from TOMS on her Facebook page, saying that the company completely agrees and that the wording has been changed to now say "new arrivals for kids." "We're really grateful whenever our community brings something like this to our attention," said Doug Piwinski, senior vice president, global marketing and communications for TOMS. "Perhaps as much or more than any other brand, I mean we really listen to our customers in our community." So, here's my question: Are the two speedy responses from companies after women spoke out on social media more a sign that companies are truly getting it about gender stereotypes and girl and boy empowerment, or more a sign of the power of parents? Or are they a mixture of both? How to Super Bowl #LikeAGirl . Wardy said there's no doubt that companies are in business to protect their bottom line, and that will always be a motivator. But she said these back-to-back incidents show what can happen when parents make it clear they won't buy products from companies that sell gender stereotypes. " 'Be not silent' is my mantra. Speak up!" Wardy said. "The success with Springs Creative and TOMS and other wins we've had in the past is an example of the power of parents (moms and dads) and children's advocates aggregating their voices to say, 'Enough is enough.' " Veronica said it's a sign of the power of parents becoming "more aware, reactive and using social media to make their voices heard by companies that market to children." She added, "One voice can be dismissed; the hailstorm of voices collectively cannot be ignored so easily." It is clear, from these two examples, that parents using their voices online and with their wallets can encourage companies to change. There's no question that raising awareness about stereotypes helps, said Wardy. "If companies aren't paying attention by now, they most certainly should be." Pink, princess-y and sexy too soon . Do you think more companies are getting the message to include girl characters on merchandise? Share your thoughts with Kelly Wallace on Twitter or CNN Living on Facebook.

A mom of two got upset when "Big Hero 6" fabric didn't include the two female characters .
Another mom called attention to gender stereotypes on a TOMS Web page .
In both cases, the companies responded quickly to answer parents' concerns .


(CNN)Blinky and Pinky on the Champs Elysees? Inky and Clyde running down Broadway? Power pellets on the Embarcadero? Leave it to Google to make April Fools' Day into throwback fun by combining Google Maps with Pac-Man. The massive tech company is known for its impish April Fools' Day pranks, and Google Maps has been at the center of a few, including a Pokemon Challenge and a treasure map. This year the company was a day early to the party, rolling out the Pac-Man game Tuesday. It's easy to play: Simply pull up Google Maps on your desktop browser, click on the Pac-Man icon on the lower left, and your map suddenly becomes a Pac-Man course. Twitterers have been tickled by the possibilities, playing Pac-Man in Manhattan, on the University of Illinois quad, in central London and down crooked Lombard Street in San Francisco, among many locations: .

Google Maps has a temporary Pac-Man function .
Google has long been fond of April Fools' Day pranks and games .
Many people are turning their cities into Pac-Man courses .


(CNN)Would you want a TV program about your family history to include details of a distant, long-deceased relative who had owned slaves? Seriously, who in their right mind would want to be tarnished by the sins of an ancestor you had no connection to other than a remote bloodline? I wouldn't, and neither did Ben Affleck, who lobbied producers of a PBS show, "Finding Your Roots," to remove any reference to his great-great-great grandfather Benjamin Cole, a Georgia slave owner in the mid-1800's, in an episode that looked at Affleck's family history. (Affleck revealed Cole's name Wednesday night.) Here's the thing that might surprise many, given the tendency of the media to exploit any potentially scandalous material: The show's producer, Harvard professor Henry Louis Gates Jr., apparently acquiesced to Affleck's request, because when the episode aired in October 2014, there was no mention of the star's slave-owning ancestor. Affleck's attempt to alter the content of the program only publicly became known a few days ago after WikiLeaks released hacked emails revealing an exchange between Gates and Sony Pictures chief Michael Lynton. When Gates asked how he should respond to Affleck's request to delete the material, Lynton responded, "all things being equal, I would definitely take it out." And on Tuesday, Affleck, via Facebook, admitted that he had urged Gates to excise any reference to his slave-owning relative. Affleck explained, "I didn't want any television show about my family to include a guy who owned slaves. I was embarrassed. The very thought left a bad taste in my mouth." Now Gates has publicly denied that he made his decision about the content of the program based on Affleck's request, but it seems likely that he did. After all, Affleck noted as much in his Facebook post, writing that Gates "agreed with me on the slave owner but made other choices I disagreed with." And three other celebrities profiled on the series last season were shown to have been related to slave owners. So it's unlikely that it was simply happenstance that it left out any reference to Affleck's familial slave ownership connection. In any event, PBS has launched an internal review to determine if the show violated its own editorial standards. Whatever the results of the review, Affleck and Gates did the right thing. Let's be clear: "Finding Your Roots" is not an investigative news show; it's an entertainment program. In fact, as Affleck noted, much of the material is provided directly by the celebrity being profiled. It's not "60 Minutes" but more in the nature of a sophisticated profile of celebrities, using their marquee names to attract viewers. There's not even a hint that Affleck strong-armed the producers or made any type of threats against them if they included the information. In the emails between Gates and Lynton, which they presumably believed at the time were confidential and would remain so, there was no mention of undue pressure by Affleck. Instead, Gates simply noted that Affleck  "asked us to edit out something." After the emails were revealed, Gates issued a statement, saying, "Ultimately, I maintain editorial control on all of my projects and, with my producers, decide what will make for the most compelling program. In the case of Mr. Affleck we focused on what we felt were the most interesting aspects of his ancestry -- including a Revolutionary War ancestor, a third great-grandfather who was an occult enthusiast, and his mother who marched for civil rights during the Freedom Summer of 1964." My view would be different if Affleck had a history of uttering racist remarks or engaging in racist conduct. That would have made the information truly newsworthy. But instead we have a man known for championing progressive causes, which I'm sure made him even more acutely sensitive that some on the right might possibly use this information against him in the future. Perhaps that's what Affleck meant in his Facebook post when he wrote that this information made him feel "vulnerable." Affleck has noted that he regrets asking PBS to not include information about his "distant relative."  That's a nice gesture, but it was not needed. Affleck had every right to ask for the information about a long-deceased distant relative to be left out of the show. And PBS had the choice to include it or leave it out. I applaud PBS for doing the right thing at a time when media outlets rarely show any restraint on the lives of people in the public eye.

Ben Affleck admits he asked PBS show "Finding Your Roots" to avoid mentioning his slave-owning ancestor .
Dean Obeidallah says the actor and the show were right to leave the detail out .