Amazing!

This soundtrack is my favorite music of all time, hands down. The intense sadness of "Prisoners of Fate" (which means all the more if you've played the game) and the hope in "A Distant Promise" and "Girl who Stole the Star" have been an important inspiration to me personally throughout my teen years. The higher energy tracks like "Chrono Cross ~ Time's Scar~", "Time of the Dreamwatch", and "Chronomantique" (indefinably remeniscent of Chrono Trigger) are all absolutely superb as well.This soundtrack is amazing music, probably the best of this composer's work (I haven't heard the Xenogears soundtrack, so I can't say for sure), and even if you've never played the game, it would be worth twice the price to buy it.I wish I could give it 6 stars.


Excellent Soundtrack

I truly like this soundtrack and I enjoy video game music. I have played this game and most of the music on here I enjoy and it's truly relaxing and peaceful.On disk one. my favorites are Scars Of Time, Between Life and Death, Forest Of Illusion, Fortress of Ancient Dragons, Lost Fragment, and Drowned Valley.Disk Two: The Draggons, Galdorb - Home, Chronomantique, Prisoners of Fate, Gale, and my girlfriend likes ZelbessDisk Three: The best of the three. Garden Of God, Chronopolis, Fates, Jellyfish sea, Burning Orphange, Dragon's Prayer, Tower Of Stars, Dragon God, and Radical Dreamers - Unstealable Jewel.Overall, this is a excellent soundtrack and should be brought by those that like video game music.Xander Cross


Remember, Pull Your Jaw Off The Floor After Hearing it

If you've played the game, you know how divine the music is! Every single song tells a story of the game, it's that good! The greatest songs are without a doubt, Chrono Cross: Time's Scar, Magical Dreamers: The Wind, The Stars, and the Sea and Radical Dreamers: Unstolen Jewel. (Translation varies) This music is perfect if you ask me, the best it can be. Yasunori Mitsuda just poured his heart on and wrote it down on paper.


an absolute masterpiece

I am quite sure any of you actually taking the time to read this have played the game at least once, and heard at least a few of the tracks here. And whether you were aware of it or not, Mitsuda's music contributed greatly to the mood of every single minute of the whole game.Composed of 3 CDs and quite a few songs (I haven't an exact count), all of which are heart-rendering and impressively remarkable, this soundtrack is one I assure you you will not forget. It has everything for every listener -- from fast-paced and energetic (Dancing the Tokage or Termina Home), to slower and more haunting (Dragon God), to purely beautifully composed (Time's Scar), to even some fantastic vocals (Radical Dreamers).This is one of the best videogame soundtracks out there, and surely Mitsuda's best ever. ^_^


Buyer beware

This is a self-published book, and if you want to know why--read a few paragraphs! Those 5 star reviews must have been written by Ms. Haddon's family and friends--or perhaps, by herself! I can't imagine anyone reading the whole thing--I spent an evening with the book and a friend and we were in hysterics reading bits and pieces of it to one another. It is most definitely bad enough to be entered into some kind of a "worst book" contest. I can't believe Amazon even sells this kind of thing. Maybe I can offer them my 8th grade term paper on "To Kill a Mockingbird"--a book I am quite sure Ms. Haddon never heard of. Anyway, unless you are in a mood to send a book to someone as a joke---stay far, far away from this one!


Glorious story

I loved Whisper of the wicked saints. The story was amazing and I was pleasantly surprised at the changes in the book. I am not normaly someone who is into romance novels, but the world was raving about this book and so I bought it. I loved it !! This is a brilliant story because it is so true. This book was so wonderful that I have told all of my friends to read it. It is not a typical romance, it is so much more. Not reading this book is a crime, becuase you are missing out on a heart warming story.


A FIVE STAR BOOK

I just finished reading Whisper of the Wicked saints. I fell in love with the caracters. I expected an average romance read, but instead I found one of my favorite books of all time. Just when I thought I could predict the outcome I was shocked ! The writting was so descriptive that my heart broke when Julia's did and I felt as if I was there with them instead of just a distant reader. If you are a lover of romance novels then this is a must read. Don't let the cover fool you this book is spectacular!


Whispers of the Wicked Saints

This was a easy to read book that made me want to keep reading on and on, not easy to put down.It left me wanting to read the follow on, which I hope is coming soon. I used to read a lot but have gotten away from it. This book made me want to read again. Very enjoyable.


olly on saniye duraklat


Matthew Mercer introduces himself and the concept of Critical Role. The introduction videos for Grog, Keyleth, Percy, Scanlan, Tiberius, Vax'ildan, and Vex'ahlia are shown.

Hello everyone. My name is Matthew Mercer,

voice actor and Dungeon Master for Critical Role

on Geek & Sundry, where I take a bunch of other

voice actors and run them through a fantastical

fantasy adventure through the world of Dungeons &

Dragons. We play every Thursday at 7:00pm Pacific

Standard Time on Geek & Sundry's Twitch stream.

Please come watch us live if you have the

opportunity. Back episodes and future episodes

will be uploaded on the Geek & Sundry website. You

can also check them out there. In the meantime,

enjoy!


Matt explains how their eight-player game has been switched over from Pathfinder to Dungeons & Dragons 5th Edition. One of the players, Ashley Johnson, who plays the gnome cleric Pike Trickfoot, is not present because she is in London at the BAFTA awards.

Hello everyone. My name is Matthew Mercer,

voice actor and Dungeon Master for Critical Role

on Geek & Sundry, where I take a bunch of other

voice actors and run them through a fantastical

fantasy adventure through the world of Dungeons &

Dragons. We play every Thursday at 7:00pm Pacific

Standard Time on Geek & Sundry's Twitch stream.

Please come watch us live if you have the

opportunity. Back episodes and future episodes

will be uploaded on the Geek & Sundry website. You

can also check them out there. In the meantime,

enjoy!

Welcome to first episode of Critical Role,

and what this basically is is a continuation of

our weekly D&D game. Me and a bunch of other

likely nerdy and enjoyable voice actors gathering

around, rolling some dice, killing some creatures,

having some adventure. Now we have the pleasure of

bringing it on the stream for you to watch,

enjoy, and occasionally interact with. Before we

get to that, to give you a little backstory on the

characters you'll be seeing this evening, we're

going to play some videos for you in a second. Do

note for all you hardcore gamers out there, a lot

of this is house-ruled, loosey-goosey having a

good time. So all you number crunchers, stop

paying attention there, just have fun with it.

Nevertheless, we have some background story on

many of the characters you'll be seeing this

evening to help you jump into the story. Let's go

ahead and enjoy those in a minute, then we'll

introduce the players. So have fun!

Right, listen up! If you have ale, then

you have a friend in Grog Strongjaw! A goliath of

towering height and size, this barbarian has an

appetite for the two great loves in his life:

combat, women, and ale!

[record scratch]

Wait. Easily the brains of the group, Grog

is often consulted for his vast knowledge of

shapes, colors, and shiny things! Also ale. In his

early years, armed with his two-handed greataxe,

Grog often enjoyed proving his might amongst the

ranks of his family's wandering herd. But after

coming upon an unsuspecting elderly gnome in the

woods, he objected to the killing of such an innocent

life. A creature of impulse, Grog felt only pity

for this-- well, this terrified little thing. And

his disobedience cost him dearly. Beaten bloody,

and banished by the herd leader, his Uncle Kevdak,

Grog was abandoned and left to die. Exiled from

his herd, it was then that the relative of the

very gnome he fought to save, saved him. It was

the kindness of a gnome cleric named Pike that

healed Grog, bringing him back from death's edge.

And they have remained close friends ever since.

Most nights, Grog can be found challenging entire

taverns to wrestling matches! Or accompanying

Scanlan to the nearest house where you pay for

lady favors. Also ale!

A first impression of Keyleth would leave

you with little information on the half-elven

druid. You might even think that her social

awkwardness due to her sheltered upbringing is

kind of sweet. Of course, it would be unwise

underestimate her based on first impressions.

[thunder crack]

Under that un-intimidating petite frame

is a vicious beast waiting to be unleashed, whose

natural powers have made even the fiercest of

champions pee their pants, literally! Born to the

Air Tribe of the Ashari people, Keyleth was raised

with a deep love of nature and the elemental

magics. It is her people's inherent duty to

protect the delicate areas in Tal'Dorei where the

four elemental planes begin to bleed with this

realm. Since she was a little girl, she had quite

a knack for air manipulation and beast shaping

abilities. Well, if you consider kittens and

flying squirrels to be little beasts. Which, I do.

Anyways, it wasn't long before the headmaster of

the tribe, her father, Korren, realized her true

prodigious abilities and she was inveterated to

succeed him as the next headmaster. Just like

that, her jovial childhood was stripped and

replaced with endless spell memorization,

teachings from ancient traditions, and exceedingly

high expectations. Every druid leader-to-be must

embark on a journey to seek out the sister tribes in

order to introduce and establish respect amongst

the fellow headmasters. They call this the

Aramente, or Noble Odyssey. When her father felt

she was ready, he set her on the path to truly

discovering herself, not knowing when, or if, she

will ever return. As she hiked down the mountain

towards Stilben, she meditated on the task ahead.

Part of the Aramente is proving yourself a strong

warrior, a valiant protector, and a wise and

compassionate leader. With this knowledge, one

thought plays in repeat in her mind: Is she even

worthy?

Percy was the third child of seven

children, born to a noble family who lived far to

the north in the ancient castle of Whitestone.

With so many siblings to share the burdens of

lordship, Percy turned his attention to the

sciences, engineering, and naturalism. One day, a

mysterious couple, named Lord and Lady Briarwood,

came to court. During a feast held in their honor,

the Briarwoods violently took control of the

castle, killing or imprisoning everyone who would

stand in their way. Percy awoke chained in the

dungeon, only to be freed by his younger sister.

Together they fled, chased by the Briarwoods' men.

As they ran, Percy's sister took several arrows to

the chest and fell. Percy kept running, eventually

jumping into a freezing river and floating

unconscious to freedom. He did not remember waking

up on a fishing boat. He barely remembered the

next two years, as he slowly made his way as far

south as possible. Then one night, Percy had a

dream. A roaring cloud of smoke offered him

vengeance against those who destroyed his family.

When he awoke, Percy began to design his first

gun.

Oh, you haven't heard of Scanlan Shorthalt?

Well, gird your loins, ladies, because he has his

eye on you. A talented musician, master of

disguise, and dashingly handsome in his own mind,

Scanlan sings songs almost as much as he sings his

own praises. Born a poor gnome, Scanlan used his

endless charm and soaring tenor voice to croon for

coin and support his single mother. One day, he

was discovered by a half-orc promoter, and joined

Dr. Dranzel's Spectacular Traveling Troupe where

he learned the ways of the world, and honed his

skills as a bard extraordinaire. A loner much of

his life, Scanlan has never quite come to terms

with the violent death of his mother at the hands

of a goblin invasion. While his years on the road

provided many, shall we say, educational

experiences with the opposite sex, deep down

Scanlan yearns for the one thing he's never known:

the true love of a fellow gnome. Still, Scanlan

considers himself a lover first, performer second,

and fighter distant third. On the battlefield,

he'll support his allies, but rarely draws blood,

unless it's to protect fellow gnome, Pike. Count

on Scanlan for a hearty laugh, a rollicking song,

and a twinkle in his eye that melts hearts and

makes the females swoon.

Greetings and salutations, I am Tiberius

Stormwind. I hail from a town called Ty'rex,

located in the heart of Draconia, born from a

politically respected family. At the age of 15, I

succeeded in passing the Sorcerer's Rite, showing

prodigy-like control of my magic. The judges and

the Draconian high council were amazed at how

powerful my spells were for how long I had been

training. At 20 years old, I was the youngest

appointed member of the magic guild in Draconian

history. For the next few years, I almost went mad

from the malaise of being a guild member, as it's

rather boring. However, one day I happened upon a

chamber, unused for quite some time. In the room

were stacks of books and maps of the surrounding

cities and areas around the known world. For

months, I would frequent the chamber, and learned

of artifacts from legend. After a long period of

research, I made a list of artifacts that caught

my eye. I brought these findings to the high

council and was told that all of the information

in the chamber I had stumbled upon was either

believed to be fiction, or unsolvable mysteries,

and hence were lost forever. I found those answers

to be unacceptable. A year later, I devised a ruse

and managed to convince the city council to lend

support in me leaving Draconia on a mission of

peace and diplomacy for the surrounding kingdoms.

Going from town to town and making friends and

allies in and for the name of Draconia. Being a

red dragonborn, I had quite the task on my hands

in that respect, but it was exactly what I needed

so I could explore the world and find these

artifacts, as I felt the truth was out there. Some

may describe me as buffoonish, but I say poppycock

to all that. I am much sharper than most give me

credit for. I just don't pay attention to things

sometimes. I've also been known to be rather

cunning, loyal, happy-go-lucky, and well,

dangerous. I can't help but show my true scales

every now and then. But overall, I think I'm quite

friendly for a dragonborn.

Never entirely welcome in the company of

elves or men, Vax'ildan learned at a young age to

skip past formality, preferring instead to invite

himself in your door. Along with twin sister

Vex'ahlia, Vax was born by a chance encounter

between elven royalty and human peasantry. Raised

by their mother in their early years, the twins

were eventually sent off to their father in the

elven capital of Syngorn. But their cool reception

among the elves there never warmed, and their time

in the capital didn't last. The siblings stole

away one autumn night and set out on the open

road. After a few years of wandering, they

eventually decided to return to their mother, and

journeyed back to the lands of their youth. But

instead of finding their childhood home, they

returned to a pile of rubble. Their mother was

gone, their home burned to ash. Pressing the

townspeople for answers, they learned of the day

the dragon came. With their ties all severed,

Vax'ildan and his sister set out to find their

fortune together in Tal'Dorei. An outsider since

birth, Vax quickly learned to solve life's

challenges in his own particular way, often by

sidestepping them entirely. And when his knack for

circumventing adversity isn't enough, the way of

blades the elves schooled him in more than makes

up the difference.

Like so many half-elves, Vex'ahlia has

spent most of her life suffering the cool

reception of a people who don't fully accept her.

Born of a human mother, and an elven father who

only later in life took an interest in their

existence, Vex'ahlia and her twin brother,

Vax'ildan, quickly realized the only people they

could truly rely on in this world were each other.

It was at the age of ten when the two were taken

from their mother, and brought to live in Syngorn,

the isolated elven city for which their father was

an ambassador. He quietly took them in, but always

kept an icy distance, and after too many years of

disdainful looks, the pair decided to leave his

indifference behind, and set out on their own. Vax

took to the cities, stealing small trinkets and

learning the ways of the thief, while Vex kept to

the woods. She preferred the isolation. Always the

keen observer, she learned to hunt and to track,

to spy and to shoot. Through a series of fateful

events, earned herself a companion in the form of

a bear-- her own stolen Trinket-- to fight

alongside her and protect her fiercely. Also, he

is adorable, and gives expert massages. Like so

many half-elves--

Hey guys, welcome back. To give you a little

heads up, we are playing the 5th edition of

Dungeons & Dragons. We recently converted over

from Pathfinder, for those who play Pathfinder.

One of our players was a gunslinger, for which

there are no rules for in 5th edition. So I had to

create and customize those for the game, so bear

with us on that. That will be an interesting ride,

regardless. We do have an eight-player game we've

been playing for two years, which is a little

crazy, which is why we go a little loose with the

rules. It's a great group, it's a lot of fun. Not

everyone can make every game, so we have enough

players to definitely pull a party each time.

Just so you know, we're having an audio

bottleneck. It'll take about 30 seconds to work

itself out.

Okay, audio bottleneck.

Tech problems that make me want to murder

someone.

That's okay. Just a second. You let us know

when it's okay to talk.

I don't know what that means, a

bottleneck.

Are we all right? And how are we?

Exterminate. Exterminate.

Nice. Audio isn't working they're going to

watch something else. Thanks, douche.

(laughter)

Is the mic adjusted? Is it any better?

Better now. We're good.

Well, great. Thank you guys. A couple of

things transitioned from Pathfinder to 5th edition

may be a little strange and fun. We have a lot of

players, but they're great folks and most of that

just means I have to work really hard to make sure

the game keeps going, so that's on me. Ashley

Johnson, unfortunately, cannot join us. She's our

gnome cleric, Pike. She'll be here next week.

Unfortunately, she's in London accepting a BAFTA,

so I think we're okay. For the Last of Us. That's

harsh. Also no donations this week, but going

forward we will have donations available for those

that will help partially run the show from our

wonderful cameraman and crew. Also, half of our

donations will go to the 826 charity. Marisha, if

you want to talk a little about that.


Donations will be accepted in the following weeks to support the crew. Half of the donations will go to the charity 826LA.

Well, great. Thank you guys. A couple of

things transitioned from Pathfinder to 5th edition

may be a little strange and fun. We have a lot of

players, but they're great folks and most of that

just means I have to work really hard to make sure

the game keeps going, so that's on me. Ashley

Johnson, unfortunately, cannot join us. She's our

gnome cleric, Pike. She'll be here next week.

Unfortunately, she's in London accepting a BAFTA,

so I think we're okay. For the Last of Us. That's

harsh. Also no donations this week, but going

forward we will have donations available for those

that will help partially run the show from our

wonderful cameraman and crew. Also, half of our

donations will go to the 826 charity. Marisha, if

you want to talk a little about that.

Yes! 826LA is a charity that focuses on

tutoring children in an after-school program and

helping specifically with creativity,

storytelling, art and general things that relate

to Dungeons & Dragons. You should definitely check

out the Time Travel Mart. There is one in Echo

Park and one in Mar Vista. They have this amazing

storefront where you can buy these awesome

tchotchkes and things that go immediately to

support the charity and the stream. It's awesome.

It's 826LA, you should look it up. There's a few

all over the country.


Marisha Ray explains how 826LA helps children learn creativity, storytelling, and art. She also talks about the 826LA storefront, where all proceeds go to the charity.

Yes! 826LA is a charity that focuses on

tutoring children in an after-school program and

helping specifically with creativity,

storytelling, art and general things that relate

to Dungeons & Dragons. You should definitely check

out the Time Travel Mart. There is one in Echo

Park and one in Mar Vista. They have this amazing

storefront where you can buy these awesome

tchotchkes and things that go immediately to

support the charity and the stream. It's awesome.

It's 826LA, you should look it up. There's a few

all over the country.

Yes. Also, as a heads up because I saw some

of you guys ask me in the chatroom: These videos

will be available on the Geek & Sundry YouTube

Channel soon enough, as well as a more extensive

backstory of the party. We'll have all that

content ready for you so you don't have to

memorize it. Maybe a bio page, I don't know. We'll

figure something out. It'll be fine. Anyway, let's

open that up. You know who I am. Matthew Mercer,

voice actor and I've been running this game for

two years. I'm a hardcore nerd. Let's go around

the table and introduce our players so you can

attach the faces to the intros you just saw. Let's

start on this side with Travis.


The cast introduce themselves and their roles:
 Matthew Mercer is the Dungeon Master. Travis Willingham plays Grog, the goliath barbarian.

Yes. Also, as a heads up because I saw some

of you guys ask me in the chatroom: These videos

will be available on the Geek & Sundry YouTube

Channel soon enough, as well as a more extensive

backstory of the party. We'll have all that

content ready for you so you don't have to

memorize it. Maybe a bio page, I don't know. We'll

figure something out. It'll be fine. Anyway, let's

open that up. You know who I am. Matthew Mercer,

voice actor and I've been running this game for

two years. I'm a hardcore nerd. Let's go around

the table and introduce our players so you can

attach the faces to the intros you just saw. Let's

start on this side with Travis.

Oh! Hi. I'm Travis Willingham, voice

actor, gamer. I play Grog the goliath barbarian.


Laura Bailey plays Vex'ahlia, the half-elven ranger who has a pet bear named Trinket. Liam O'Brien plays Vax'ildan, the half-elven rogue and twin of Vex'ahlia.

Oh! Hi. I'm Travis Willingham, voice

actor, gamer. I play Grog the goliath barbarian.

Hi. I'm Laura Bailey. I'm also, you know, a

voice actor like everyone here.

Yeah. I think we all are.

I'm playing Vex'ahlia. The coolest chick

ever.

The ranger with the bear.

The ranger with the bear named Trinket, in

case you didn't catch that. His name is Trinket

and he's amazing.

Hi, I'm Liam O'Brien. I'm playing Vax'ildan.

This one's twin. We're half-elven twins. I started

playing D&D when I was 13 and I can't believe this

is happening. So cheers. Cheers to this.

My name is Taliesin Jaffe. I'm a voice

actor, director, and I've been playing some form

of Dungeons & Dragons, and if you can't tell by my

black clothing, a lot of Vampire the Masquerade

when I was a teenager.

There was a problem. I'm playing Percy, the

Gunslinger. I'm the reason all the rules are all

messed up.


Taliesin Jaffe plays Percy, the human gunslinger. Marisha Ray plays Keyleth, the half-elven druid.

My name is Taliesin Jaffe. I'm a voice

actor, director, and I've been playing some form

of Dungeons & Dragons, and if you can't tell by my

black clothing, a lot of Vampire the Masquerade

when I was a teenager.

There was a problem. I'm playing Percy, the

Gunslinger. I'm the reason all the rules are all

messed up.

I am Keyleth, the druid from the tribe of

the Air Ashari. I am a half-elven person.

No, you're elven.

No, half-elf.

Half-elf. Okay.

Yeah, Come on, man. I've been half-elf

since day one. Half-elven. Yes! You can see me

shooting lightning and turning into awesome

animals.

Orion.

Hi.

Hey, everybody. I'm Orion Acaba and I'm

also a voice actor. I do things.

Oh, I'm Marisha Ray, by the way.

Yeah!

Did I say that?

Keyleth is Marisha Ray.

Let Orion have his moment. Don't try and

break--

No, it's our moment.

There you go. All right.

I'm Tiberius the awesome sorcerer.


Orion Acaba plays Tiberius, the dragonborn sorceror. Sam Riegel plays Scanlan Shorthalt, the gnome bard.

I'm Tiberius the awesome sorcerer.

Dragonborn sorcerer.

Dragonborn, yeah! That's right.

I'm Sam Riegel  a voice actor, and stuff. My

character is Scanlan Shorthalt. The gnome bard who

sings a lot. Let's start playing, yeah?

(cheering)


"The party had completed a large venture in saving the nearby city of Emon, one of the capitals of this human civilization of Tal'Dorei.

I'm Sam Riegel  a voice actor, and stuff. My

character is Scanlan Shorthalt. The gnome bard who

sings a lot. Let's start playing, yeah?

(cheering)

All right! Let's jump on in. Thank you. Last

we left off, to give you a little backstory. The

party had completed a large venture in saving the

nearby city of Emon. One of the central capitals

of this human civilization of Tal'Dorei. They

managed to halt a demonic insurrection within the

throne and as such were greeted to a hero's

celebration and had a keep built in their honor.

Over the six month period of the keep being

constructed, they went their own ways and then

returned to see its final creation. However, they

did not have a chance to really enjoy it

immediately as one of their good friends and

allies, Arcanist Allura Vysoren of the Tal'Dorei

council came to them requesting their aid saying

that a long time friend of hers, Lady Kima of

Vord, who is a very well known and very well

respected halfling paladin of Bahamut, the

Platinum Dragon, had been gone on a pilgrimage for

a while, essentially a vision quest that is part

of her own development as a paladin. As part of

this, she let the information go to Allura that a

dark vision had come to her saying that some sort

of evil root is beginning to breed beneath

Kraghammer and the mountains within Kraghammer,

which is the nearby dwarven civilization that you

guys have previously not been allowed entry to

because the dwarves weren't fans of nobody without

any political means of entry. However, she managed

to acquire the necessary documentation and offered

you a very substantial reward should you find the

whereabouts of Lady Kima of Vord and hopefully

bring her back safely. You left on the pathway to

the dwarven citadel of Kraghammer. You were

ambushed by a group of roaming barbarian goliaths.

Part way through the battle, Grog managed to

recognize one of them as a previous ally and no

longer an ally at this time.


They managed to halt a demonic insurrection within the throne and as such were greeted to a heroes' celebration and had a keep built in their honor. "Over the six month period of the keep being constructed, they went on their own ways and then returned to see its final creation.

All right! Let's jump on in. Thank you. Last

we left off, to give you a little backstory. The

party had completed a large venture in saving the

nearby city of Emon. One of the central capitals

of this human civilization of Tal'Dorei. They

managed to halt a demonic insurrection within the

throne and as such were greeted to a hero's

celebration and had a keep built in their honor.

Over the six month period of the keep being

constructed, they went their own ways and then

returned to see its final creation. However, they

did not have a chance to really enjoy it

immediately as one of their good friends and

allies, Arcanist Allura Vysoren of the Tal'Dorei

council came to them requesting their aid saying

that a long time friend of hers, Lady Kima of

Vord, who is a very well known and very well

respected halfling paladin of Bahamut, the

Platinum Dragon, had been gone on a pilgrimage for

a while, essentially a vision quest that is part

of her own development as a paladin. As part of

this, she let the information go to Allura that a

dark vision had come to her saying that some sort

of evil root is beginning to breed beneath

Kraghammer and the mountains within Kraghammer,

which is the nearby dwarven civilization that you

guys have previously not been allowed entry to

because the dwarves weren't fans of nobody without

any political means of entry. However, she managed

to acquire the necessary documentation and offered

you a very substantial reward should you find the

whereabouts of Lady Kima of Vord and hopefully

bring her back safely. You left on the pathway to

the dwarven citadel of Kraghammer. You were

ambushed by a group of roaming barbarian goliaths.

Part way through the battle, Grog managed to

recognize one of them as a previous ally and no

longer an ally at this time.


this is wild surreal stuff , but brilliant and the camera just kind of sits there and lets you look at this and its like you 're going from one room to the next and none of them have any relation to the other .


i had to look away - this was god awful .


one of creepiest , scariest movies to come along in a long , long time , easily rivaling blair witch or the others .


a disappointment for those who love alternate versions of the bard , particularly ones that involve deep fryers and hamburgers .


ultimately feels empty and unsatisfying , like swallowing a communion wafer without the wine .


it 's worth seeing just on the basis of the wisdom , and at times , the startling optimism , of the children .


it 's of the quality of a lesser harrison ford movie - six days , seven nights , maybe , or that dreadful sabrina remake .


the film is based on truth and yet there is something about it that feels incomplete , as if the real story starts just around the corner .


not exactly the bees knees


The mushroom's are large and of outstanding quality. We use them anywhere instead of button mushrooms.  The real secreat here is to use the warm water that remains when you reconstitue them, in your dish.  We use it when making reisots and it makes all the difference in the world!  These are quality mushrooms, and cheaper than buying the same mix (fresh)at the grocery store.


I absolutely love my Keurig. But every now and then I found myself getting bored with the selection of K-Cups. I resorted to buying a reusable K-Cup and filling it with freshly ground beans from Starbucks. The results were less than desirable. I would never get the mesaurements right and I would end up having to make a trip to get coffee.<br />These K-Cups from starbucks are a godsend! the price is not bad. The ratio of coffee grounds to water is the same every time so my coffee comes out great. I am a happy person once again! I also love the house blend because even though it says its a lighter blend, its starbucks. Its roasted darker than most. So if you are a strong coffee lover i think the house blend will suit you just fine.


My husband usually uses the generic version Head and Shoulders and thinks this is just as good. It has a nice light scent and leaves his normally coarse feeling hair nice and soft. He has no problems with dandruff when usuing this shampoo. The only drawback for me is the price, I think we will stick with the generic unless this is on sale and we have a coupon.


All the kids and myself Love these! Taste just like Ice Cream we eat normally! Worth the price and i am happy with the product and the purchasing/shipping! No complaints!


Pamela's Products Peanut Butter Chocolate Chip Cookies are tastier than their gluten counterpart. The flavor is spot on and the dough is lighter than regular wheat products. Shipping did break a few of the cookies. But I ate the pieces all the same.


These things taste great but the price on Amazon swings wildly (and widely) so stock up when the prices is low.


Should've figured this out- a product that is shipped unrefrigerated can't have any dairy in it, and therefore cannot contain any of the wonderful filling of real tiramisu.  It't more like sponge cake with generic, flavorless 'creme' spread inside.  No coffee taste, no liquor-soaked ladyfingers, no cool creamy dairy; boring.  Not worth the calories.


My wife, who is gluten intolerant, was excited in finding out that Betty Crocker finally made gluten free products. A friend of ours made cupcake versions with chocolate frosting and they were yummy! The Betty Crocker brownies are excellent (even better if you add chocolate chips), but the cookies not so much.

For those that think that soy flour is gluten, it is not. When some people think of "soy," immediately thinks of gluten. It's because some soy sauce are derived from wheat, but there are some that are not and are gluten free. Soy flour, however, is made from soybeans which are gluten free. If you have gotten sick from eating this product it must be from something else.


The Dove Men+ Deep Clean body wash is nothing to write home about. You use it to wash with, then you rinse it off, just like hundreds of similar other products. This one is better than a lot in that the scent is not too overpowering. Some products cause me to have a rash. This one does not, so that has to be a positive. All in all this product isn't better or worse than most available & if it was on sale for less than others I'd buy it.


What I like best is that these k-cups come in a twin pack.  I get 48 delivered in one shot and do not pay shipping harges.  The products usually arrives within 3-4 days right before I run out of my supply. Perfect!


i start to feel emotional


i believe feeling duality suffering soul growth tells of an ending or a decline or a change of direction often one associated with emotions and it offers one possible response to that decline or change moving on


i hostage negotiator on her case has her feeling hopeful about her future


im feeling a little dirty


i can cope with his presence without feeling distressed if i can force myself into a quiet and resigned friendship


i had the feeling that it might not have been taken as the truthful and sincere compliment it would have been


i asked some girls what it meant to them to be valued and for the most part the response was that they felt valued when the people around them made them feel valued and treated them in a loving and caring manner


i feel if i completely hated things i d exercise my democratic right speak my mind in what ever ways possible and try to enact a change


i could almost feel her gentle touch in the moonbeam she sent to shine over me he added touching his face dreamily


i woke up very early this morning feeling joyful


Abstract: A statistical model for segmentation and word discovery in child directed speech is presented. An incremental unsupervised learning algorithm to infer word boundaries based on this model is described and results of empirical tests showing that the algorithm is competitive with other models that have been used for similar tasks are also presented.

Model Based Dynamic Programming, hereafter referred to as MBDP-1 @cite_0 , is probably the most recent work that addresses the exact same issue as that considered in this paper. Both the approach presented in this paper and Brent's MBDP-1 are based on explicit probability models. Approaches not based on explicit probability models include those based on information theoretic criteria such as MDL , transitional probability or simple recurrent networks . The maximum likelihood approach due to Olivier:SGL68 is probabilistic in the sense that it is geared towards explicitly calculating the most probable segmentation of each block of input utterances. However, it is not based on a formal statistical model. To avoid needless repetition, we only describe Brent's MBDP-1 below and direct the interested reader at Brent:EPS99 which provides an excellent review of many of the algorithms mentioned above.

Abstract: This paper presents a model-based, unsupervised algorithm for recovering word boundaries in a natural-language text from which they have been deleted. The algorithm is derived from a probability model of the source that generated the text. The fundamental structure of the model is specified abstractly so that the detailed component models of phonology, word-order, and word frequency can be replaced in a modular fashion. The model yields a language-independent, prior probability distribution on all possible sequences of all possible words over a given alphabet, based on the assumption that the input was generated by concatenating words from a fixed but unknown lexicon. The model is unusual in that it treats the generation of a complete corpus, regardless of length, as a single event in the probability space. Accordingly, the algorithm does not estimate a probability distribution on wordss instead, it attempts to calculate the prior probabilities of various word sequences that could underlie the observed text. Experiments on phonemic transcripts of spontaneous speech by parents to young children suggest that our algorithm is more effective than other proposed algorithms, at least when utterance boundaries are given and the text includes a substantial number of short utterances.


Abstract: We present an open architecture for just-in-time code generation and dynamic code optimization that is flexible, customizable, and extensible. While previous research has primarily investigated functional aspects of such a system, architectural aspects have so far remained unexplored. In this paper, we argue that these properties are important to generate optimal code for a variety of hardware architectures and different processor generations within processor families. These properties are also important to make system-level code generation useful in practice.

Pioneering research in dynamic runtime optimization was done by Hansen @cite_8 who first described a fully automated system for runtime code optimization. His system was similar in structure to our system---it was composed of a loader, a profiler, and an optimizer---but used profiling data only to decide when to optimize and what to optimize, not how to optimize. Also, his system interpreted code prior to optimization, since load time code generation was too memory and time consuming at the time.

Abstract: Abstract : This thesis investigates adaptive compiler systems that perform, during program execution, code optimizations based on the dynamic behavior of the program as opposed to current approaches that employ a fixed code generation strategy, i.e., one in which a predetermined set of code optimizations are applied at compile-time to an entire program. The main problems associated with such adaptive systems are studied in general: which optimizations to apply to what parts of the program and when. Two different optimization strategies result: an ideal scheme which is not practical to implement, and a more basic scheme that is. The design of a practical system is discussed for the FORTRAN IV language. The system was implemented and tested with programs having different behavioral characteristics.


Page 3 is most definitely a very enthralling and captivating eye-opener that very cleverly exposes the hypocrite lifestyles of Mumbai's elite. From the fake kisses to the plastered smiles, Page 3 leaves no stone unturned in revealing the shocking lives of the rich and the famous. Backstabbing, gossip, corruption, and scandal lurk in every dark corner in the world of glitz and glam. Humanity and generosity are analogous to an oasis in the desert in this world where Social Darwinism is the prevailing mentality. Everyone is constantly craving for more money, more fame, and a higher reputation, driving them to do the most shameful things imaginable ranging from signing film contracts at a funeral to child molestation. Anything is possible in this metropolis where there is a such a wide gap between the social classes. The audience sees the ugliness of both of these classes through the eyes of the protagonist. She observes the suffocating atmosphere and the mind-boggling frenzy that the socialites live in. Bollywood, business tycoons, politicians, and the underworld are all intertwined in a completely convoluted mess! Kitne Ajeeb Hai is a nice track as is the peppy Kuan Main Doob Jaongi. Terrific film with excellent character development!


Before I'd seen this, I had seen some pretty bad Christmas films. But once I saw this, "Jingle All the Way" looked better than "The Godfather". "Santa Claus" is a jolly film about Santa helping out some kids, but it almost feels demonic watching it. Santa's jolly ho-ho-ho is replaces by an evil, devilish laugh that I'm sure has turned many kids off of Christmas. The plot of this massacre is very strange, which fits along with all of the performances and dialog. Santa lives high above Earth in the North Pole where he, and kids from all around the world get ready for Christmas. But Santa has an enemy named Pitch, or Satan. Pitch tries to ruin Santa's Christmas by making three boys naughty, and by creating diversions, like moving the chimney and making the doorknob hot. When Pitch causes Santa to be attacked by a dog, it's up to Santa's helper Pedro and Merlin the wizard to get Santa out of this pickle.

Everything about this film, along with being downright bad, is so bizarre. Satan dances a lot and he actually seems much more merry than Santa. Santa talks about delivering presents to all the boys and girls, yet he seems to only deliver to 5 houses of kids in Mexico. The reindeer are wind up toys, and when the reindeer laughs, I'm amazed it doesn't bring tears to kid's eyes...it's frightening. Everything is terrible. The first 10 minutes are simply Santa playing the organ while kids sing to it. Probably one of the strangest scenes is Santa shooting Pitch in the butt with a mini-cannon and uproariously laughing about it while Pitch dances around in pain. I think parents are better off telling their little kids about where babies come from, than showing them this. The only positive is it will have you laughing hysterically if you can appreciate bad cinema.

My rating: BOMB/****. 85 mins.


Another big star cast, another glamour's set, another reputed director, another flick filled with songs that's topping the chart buster, but alas what's missing at the day end is a story that every moviegoer expects of from such a big budget motion picture. So much hype is what that was lurking around the movie before it's' red carpet premiere. A hype which went to an extent where Anil Kapoor envisages that the movie would be one of the finest love stories ever made after Dilwale Dulhaniya Le Jayenge. Well Anilji, which movie were you speaking of? Well the plot of the movie is about 6 different couples and 12 different people, who have a total different stance towards life, but despite their different approach towards life they all have one common problem, that's LOVE. Well indeed a luring theme. But little did we expect that the movie would be such boredom that it will let down the last expectation the audience would have from such a multistarrer movie. These are kinda movies which I totally abhor because after spending a hefty buck for a multiplex ticket I get locked in the theatre for 4 hours just waiting in agony for the climax.

The trouble begins right from the start. The director gets so confused with the plot that somewhere even he gets baffled as to how to share the time slot to six different star casts. Some of the couples like Anil Kapoor-Juhi and Sohail Khan-(Whoever the female is opposite to him) just doesn't make any sense for their existence in the movie. Salman (Who calls himself rahul in a weird manner for the entire movie. Well something like Rahoooooool) again as usual tries to be extra cool with his Videsi kinda Hindi accent. Hey Sallu Bhai, now that Aish is getting married, at least go get some tip from Abhishek to improve your acting abilities. A simple striptease wouldn't make the movie a box office hit every time. And Anilji stop shaving your trade mark beard or you look totally like a eunuch. And smooching a girl of your daughters' age just looks as uncool as watching Jack Nicholson in a romantic movie. And please Nikhilji avoid putting such superfluous scenes in a movie that is totally not needed for the shot.

The other bigger flaw in the movie was that there wasn't any perfect synchronization between the stories of different couples. Every story itself looks as if it is taken from different flicks, put together to form a sadistic plot of Salaam-E-Ishq. Bollywood still has to learn a lot from movies like Snatch, Memento where the director knows the perfect art of threading the different unrelated sequences to form a perfect blended storyline.

Somewhere while I was evaluating the pre-release movie reviews someone predicted that the movie wouldn't do good because the title of this movie adds up to the number 28, and 28 is considered a bad number in Numerology. But I totally take my stand by saying the movie will fail not coz of its Numerology defects, but because of the myriads of flaw that persisted in the movie. And when director like Nikhil Advani can make such major blunders in the entire storyline of the movie, any wonder wouldn't have saved the movie from bombing at the Box Office.

My suggestion for all you guys is, please avoid watching this movie at any cost. It isn't worth a pie that you pay for the ticket. There indeed are better movies on theater screens currently which are worth watching more than Salaam-E-Ishq.


I love buying those cheap, lousy DVD's from Alpha Video. One day, I happened to buy this one. It's the perfect silly science fiction film of the 50's, all sexed up. Replete with unscientific EVERYTHING, scantily clad girls and plenty of melodrama, it's an enjoyable film, to those who appreciate this kind of stuff. And if you can 'suspend your disbelief' enough, you can actually get creeped out-- not just by the psychotic head or by the beating of the thing in the closet, but toward the end, with the character of 'the perfect body'. It's so . . . . what's another word for mindf***ing?


The usual cat and mouse antics abound until Jerry jumps into a bottle of invisible ink. He gets the bright idea of torturing Tom without him knowing. The cat gets wise and tries to do stuff to make him 'see' jerry even if it's not fool-proof. Of course Jerry gets Butch aka Killer aka Spike the dog into the act (even if it's late in the short, and his contribution is minimal indeed) Brilliant animated short which kind of reminded me of the one with the white mouse who scares Tom so badly. Most of the gags work and all violent as any good tom and jerry short should truly be. This hilarious cartoon can be found on disc one of the Spotlight collection DVD of "Tom & Jerry"

My Grade: B+


A question for you : A family go to a new house and get stalked by demonic forces . Which film am I talking about ? Every horror film you`ve seen ? Yes that`s true but that`s not the answer I`m looking for . I`ll narrow it down by saying there`s a lot of teen angst scenes . Doesn`t help ? Well there`s lots of bits where the characters are stalked by a creature and you see the characters through the creature`s POV . No futher forward ? Okay there`s a dream sequence involving lots of blood ? Could still be any horror film you say . Oh gawd this could take weeks so I`ll say the film I`m talking about features loads of Aussies many of whom have appeared in NEIGHBOURS and HOME AND AWAY . Yes that`s right the film is THE THIRD CIRCLE ( aka CUBBYHOUSE ) and do you understand what the above exercise is about ? It`s about me pointing out how THE THIRD CIRCLE is absolutely no different from any horror film that`s been made


Sam Fuller's excellent PICK UP ON SOUTH STREET is the pick of the bunch from a number of early 50's Cold War-influenced low-budget noir vehicles. With a running length of under 80 minutes, PICK UP ON SOUTH STREET is tough, gritty, explosive and endlessly entertaining.

Widmark stars as pickpocket Skip McCoy, who has already been picked up three times. Yet McCoy can't keep his wandering fingers out of trouble- and trouble is exactly what he slides into when he grifts the wallet of gangster's moll Candy (Jean Peters). Candy's wallet contains a roll of microfilm invaluable to the Communist movement, and it's her last job for ex-boyfriend Richard Kiley to make the delivery. However, when Widmark lifts it, Peters must do whatever it takes to re-claim the film she (initially) knows nothing about.

It's a tasty set-up, with Widmark's character, while not the psycho of KISS OF DEATH, a real live-wire, unpredictable and tough, yet curiously charming.When Bogart or Mitchum stepped into a film noir role you knew what you were going to get: a lone anti-hero maintaining his moral integrity and winning out in the end (Bogart), or an overly-laconic guy who allows himself to be drawn into a trap (Mitchum). With Widmark you just don't know what you are going to get, and with his incredibly modern acting style (his films always hold up well) he is amazing to watch. Here he is torn between making a big score for himself by selling the film, or handing it over to the police and fighting the "Commies" on the right side of the law. And he still has to pretend he never pickpocketed Peters to avoid the fatal fourth rap on his sheet.

Peters gets her best role as the moll-with-a-heart-of-gold Candy. Widmark's unpredictability is perhaps best expressed in his scenes with Peters; the gorgeous tramp quickly (and rather unbelievably- the romance angle is rather rushed)falls under Widmark's spell, yet Widmark alternates between kissing her or slapping her around. Peters hard-edged beauty, yet lack of over-lacquered Hollywood glamour (Lana Turner would never have worked well in this role), is a major asset to the film. Candy is not innocent, yet she's very vulnerable, constantly being passed between and slapped around by men. Widmark knocks her cold on first meeting and wakes her by pouring beer over her face, yet by the final act he's a lot more tender to her (after she cops one hell of a going-over from Kiley). The scene in the hospital with Peters and Widmark shouldn't work, but it does.

Thelma Ritter is brilliant as stoolie Moe, well-deserving of her Oscar nomination. Ritter's performance, like everything else in the film, is gritty, real and heartbreakingly honest. Her death scene is stunning. Fuller's camera movements and location settings are particularly interesting. Fuller loved a good close-up, and PICK UP ON SOUTH STREET is full of uncomfortable, cloistering tight shots that only enhance the tension of the plot. Fuller isn't afraid to let the camera linger on a shot for longer than standard Old-Hollywood really allowed, yet stunningly pulls away from Ritter's death scene to give the audience maximum impact. The urban locales and unusual, confronting camera angles give PICK UP ON SOUTH STREET, a bold, uncompromisingly modern look.

10/10.


Going into this movie, I had heard good things about it. Coming out of it, I wasn't really amazed nor disappointed. Simon Pegg plays a rather childish character much like his other movies. There were a couple of laughs here and there-- nothing too funny. Probably my favorite parts of the movie is when he dances in the club scene. I totally gotta try that out next time I find myself in a club. A couple of stars here and there including: Megan Fox, Kirsten Dunst, that chick from X-Files, and Jeff Bridges. I found it quite amusing to see a cameo appearance of Thandie Newton in a scene. She of course being in a previous movie with Simon Pegg, Run Fatboy Run. I see it as a toss up, you'll either enjoy it to an extent or find it a little dull. I might add, Kirsten Dunst is adorable in this movie. :3


Prvo su je pravili kao Skadar na Bojani ..

prvo biti on praviti kao Skadar na Bojana .

ADV AUX PRON VERB SCONJ PROPN ADP PROPN PUNCT

Rgp Var3p Pp3fsa Vmp-pm Cs Npmsan Sl Npfsl Z


Prophylactic indomethacin for prevention of intraventricular hemorrhage in premature infants.

Prevention of symptomatic patent ductus arteriosus with a single dose of indomethacin.

Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.

[Indomethacin in the prevention of subependymal-intraventricular hemorrhage in preterm newborns with conventional mechanical ventilation].

Short versus prolonged indomethacin therapy for patent ductus arteriosus in preterm infants.

Failure of prophylactic indomethacin to improve the outcome of the very low birth weight infant.

Indomethacin prophylaxis for patent ductus arteriosus (PDA) in infants with a birth weight of less than 1250 grams.

Prophylactic indomethacin therapy in the first twenty-four hours of life for the prevention of patent ductus arteriosus in preterm infants treated prophylactically with surfactant in the delivery room.

Prolonged indomethacin therapy for the prevention of recurrences of patent ductus arteriosus.

Abstract: The impact of early prophylactic use of intravenous indomethacin on the incidence and severity of periventricular-intraventricular hemorrhage and patent ductus arteriosus in 199 oxygen-requiring premature infants (less than or equal to 1300 g birth weight) was prospectively investigated. The trial was controlled, the infants were randomized, and the investigators were unaware of the group assignments. Patients with minimal (grade I) or no periventricular-intraventricular hemorrhage determined by prestudy echoencephalography were randomized within two birth weight subgroups (500 to 899 and 900 to 1300 g) to receive either prophylactic indomethacin (n = 99) or an equal volume of saline-vehicle placebo (n = 100). The first dose (0.2 mg/kg) was given within 12 hours of delivery and two subsequent doses (0.1 mg/kg) were administered at 12 hourly intervals. Prophylactic indomethacin significantly reduced the incidence of grades II to IV periventricular-intraventricular hemorrhage. Intraventricular hemorrhage was half as common in infants given prophylactic indomethacin as in control infants (23% v 46%, P less than .002). The reduction was manifested in both birth weight subgroups. Results of this study also confirmed a lower incidence of clinically significant patent ductus arteriosus in infants who received prophylactic indomethacin in contrast to those who received placebo (11% v 42%, P less than .001). No significant differences were found between treatment and control groups in the duration of oxygen therapy, mechanical ventilation, or hospitalization or in the incidence of pneumothorax, chronic lung disease, sepsis, necrotizing enterocolitis, retinopathy of prematurity, or death. Early prophylactic indomethacin initiated within 12 hours of delivery is effective in reducing the incidence of intraventricular hemorrhage as well as clinically significant patent ductus arteriosus in very low birth weight premature infants.

Abstract: To determine the efficacy of indomethacin to prevent the occurrence of symptomatic patent ductus arteriosus (PDA), a randomized clinical trial was conducted involving 32 preterm infants weighing 750 to 1500 g at birth who had hyaline membrane disease. By random assignment, 15 infants were given a single dose of indomethacin, 0.2 mg/kg intravenously, 24 hours after birth. Seventeen infants composed a control group for which indomethacin was reserved as treatment for symptomatic PDA. Birth weight, gestational age, male/female ratio, black/white ratio, and severity of disease were similar for both groups. Only one of the 14 survivors who received prophylactic indomethacin had symptomatic PDA, compared with nine of the 16 survivors in the control group (P = 0.007). There was no difference between the groups in development of bronchopulmonary dysplasia, duration of time endotracheal intubation, was required, duration in oxygen, duration to reach full feedings and regain birth weight, and duration of hospital stay. There was no difference between the two groups in incidence of intraventricular hemorrhage, and none developed necrotizing enterocolitis. These results indicate that the use of prophylactic indomethacin is beneficial in prevention of symptomatic PDA; the lack of differences in pulmonary sequelae or other complications may have been related to a population sample size not large enough to impart sufficient statistical power.

Abstract:
The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g). Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known.
                Soon after they were born, we randomly assigned 1202 infants with birth weights of 500 to 999 g (extremely low birth weight) to receive either indomethacin (0.1 mg per kilogram of body weight) or placebo intravenously once daily for three days. The primary outcome was a composite of death, cerebral palsy, cognitive delay, deafness, and blindness at a corrected age of 18 months. Secondary long-term outcomes were hydrocephalus necessitating the placement of a shunt, seizure disorder, and microcephaly within the same time frame. Secondary short-term outcomes were patent ductus arteriosus, pulmonary hemorrhage, chronic lung disease, ultrasonographic evidence of intracranial abnormalities, necrotizing enterocolitis, and retinopathy.
                Of the 574 infants with data on the primary outcome who were assigned to prophylaxis with indomethacin, 271 (47 percent) died or survived with impairments, as compared with 261 of the 569 infants (46 percent) assigned to placebo (odds ratio, 1.1; 95 percent confidence interval, 0.8 to 1.4; P=0.61). Indomethacin reduced the incidence of patent ductus arteriosus (24 percent vs. 50 percent in the placebo group; odds ratio, 0.3; P<0.001) and of severe periventricular and intraventricular hemorrhage (9 percent vs. 13 percent in the placebo group; odds ratio, 0.6; P=0.02). No other outcomes were altered by the prophylactic administration of indomethacin.
                In extremely-low-birth-weight infants, prophylaxis with indomethacin does not improve the rate of survival without neurosensory impairment at 18 months, despite the fact that it reduces the frequency of patent ductus arteriosus and severe periventricular and intraventricular hemorrhage.

Abstract: The results of a double blind study to evaluate the efficiency of prophylactic endovenous indomethacin versus placebo for prevention of intraventricular hemorrhage (IVH) in newborn infants between 28 to 36 weeks of age who were intubated at the delivery room and required mechanical ventilation in NICU are presented. Fourty six patients required mechanical ventilation, but 14 neonates had IVH evaluated by ultrasound when were admitted to the Unit. At least 32 infants were studied, 16 for each group. There were no differences between the groups in weight, gestational age, sex and delivery way. The mobility was the same in relation to hialine membrane disease, sepsis, pneumonie and pneumotorax. The placebo group had more frequency of PDA and mortality (P < 0.5). There were no differences in mean airway pressure and arterial gases, also in glucose, platelets and urinary volume. The indomethacin group had mayor urinary density and FeNa but the results were always in normal ranges. The IVH was the same in both groups. We concluded that the indomethacin at the levels used did not produced alterations, and if the IVH is not prevented, were observed lesser severity of the same and the frequency of PDA and mortality are lesser. But still is necessary more number of cases for best conclusions.

Abstract:
To evaluate whether a prolonged low-dose course of indomethacin would produce an improved closure rate and have fewer side effects compared with a short standard dosage schedule in the management of patent ductus arteriosus (PDA) in preterm infants.
                Sixty-one infants of gestational ages 24 to 32 weeks with a PDA confirmed with echocardiography were randomized to receive 0.2 to 0.1 to 0.1 mg/kg indomethacin in 24 hours (short course, n = 31) or 0.1 mg/kg every 24 hours 7 times (long course, n = 30). Echocardiography was done 3, 9, and 14 days after the treatment was started, and side effects were monitored.
                Primary PDA closure occurred more often in the short course group (94% vs 67%, P =.011), but the sustained closure rates were not different (74% vs 60%). Surgical PDA ligations were less frequent in the short course group than in the long course group. The short course group had a shorter duration of oxygen supplementation, less frequent symptoms of necrotizing enterocolitis, and a lower rate of urea retention. Mortality and other neonatal morbidity rates were similar.
                A prolonged low-dosage indomethacin regimen offers no advantage compared with a standard-dosage short course in the management of a hemodynamically significant PDA in preterm infants.

Abstract: Prophylactic closure of the patent ductus arteriosus (PDA) has been recommended as a means of decreasing early respiratory distress, and thereby chronic respiratory sequelae in the very low birth weight (VLBW) neonate. This study was undertaken to evaluate some possible mechanisms for the observed failure of early indomethacin therapy to achieve such improvement. 24 VLBW infants with echocardiographic evidence of PDA were randomized to receive either indomethacin or placebo at 48 h of life; and then they were studied for clinical, metabolic and laboratory signs of ductal constriction and/or reopening. Early indomethacin conferred no improvement in respiratory sequelae. However, this was not secondary to a short-term therapeutic failure. Prophylactic indomethacin, even in the VLBW infant, was successful in decreasing dilator prostaglandin production, and probably in closing the PDA and in decreasing the number of recurrences. The implications are that even with effective ductal constriction, overall morbidity is not affected.

Abstract:
Very low birth weight (VLBW, less than 1500 g) and extremely low birth weight infants (ELBW, less than 1000 g) are the premature infants that are most likely to develop symptomatic PDA. Intravenous indomethacin has proven effective in prevention of PDA in many prospective trials. This strategy will be a useful adjunctive therapy for premature infants in Thailand.
                To answer the following questions: 1. Will multiple doses of intravenous indomethacin, given to VLBW infants within the first day of life, effectively prevent the occurrence of symptomatic PDA? Are there any side effects or complications? 2. Will this strategy be more beneficial in ELBW?
                The study included thirty VLBW infants born at Ramathibodi Hospital, with birth weights ranging from 630 to 1230 g. They were randomized into 2 groups of 15 infants each. One group received 3 doses of intravenous indomethacin at the dosage of 0.2 mg/kg initially and then 0.1 mg/kg every 12 hours for 2 more doses; the second group received a placebo. The study was performed by a double blind control.
                Sixteen infants developed symptomatic PDA, 4 in the indomethacin group and 12 in the placebo group. The decrease in incidence of PDA is statistically significant. But when the data was analyzed separately for the VLBW and ELBW groups. The effects were only significantly different in ELBW but not yet significant in the VLBW group. There was a statistically significant difference in the incidence of severe intraventricular hemorrhage (IVH) (grade 3 or higher) in the ELBW infants.
                Intravenous indomethacin therapy given to VLBW infants with a birth weight of less than 1250 g decreased incidence of symptomatic PDA with no significant permanent side effects. The effect was markedly noticeable in ELBW infants. Incidence of severe IVH was also markedly decreased in the ELBW infants who received indomethacin.

Abstract:
To determine whether a course of low-dose indomethacin therapy, when initiated within 24 hours of birth, would decrease ductal shunting in premature infants who received prophylactic surfactant in the delivery room.
                Ninety infants, with birth weights of 600 to 1250 gm, were entered into a prospective, randomized, controlled trial to receive either indomethacin, 0.1 mg/kg per dose, or placebo less than 24 hours and again every 24 hours for six doses. Echocardiography was performed on day 1 before treatment and on day 7, 24 hours after treatment. A hemodynamically significant patent ductus arteriosus (PDA) was confirmed with an out-of-study echocardiogram, and the nonresponders were treated with standard indomethacin or ligation.
                Forty-three infants received indomethacin (birth weight, 915 +/- 209 gm; gestational age, 26.4 +/- 1.6 weeks; 25 boys), and 47 received placebo (birth weight, 879 +/- 202 gm; gestational age, 26.4 +/- 1.8 weeks; 22 boys) (P = not significant). Of 90 infants, 77 (86%) had a PDA by echocardiogram on the first day of life before study treatment; 84% of these PDAs were moderate or large in size in the indomethacin-treated group compared with 93% in the placebo group. Nine of forty indomethacin-treated infants (21%) were study-dose nonresponders compared with 22 (47%) of 47 placebo-treated infants (p < 0.018). There were no significant differences between both groups in any of the long-term outcome variables, including intraventricular hemorrhage, duration of oxygen therapy, endotracheal intubation, duration of stay in neonatal intensive care unit, time to regain birth weight or reach full caloric intake, incidence of bronchopulmonary dysplasia, and survival. No significant differences were noted in the incidence of oliguria, elevated plasma creatinine concentration, thrombocytopenia, pulmonary hemorrhage, or necrotizing enterocolitis.
                The prophylactic use of low doses of indomethacin, when initiated in the first 24 hours of life in low birth weight infants who receive prophylactic surfactant in the delivery room, decreases the incidence of left-to-right shunting at the level of the ductus arteriosus.

Abstract: We tested the hypothesis that prolonged maintenance indomethacin therapy would allow more effective closure of patent ductus arteriosus (PDA) and thereby decrease the recurrence rate. Thirty-nine low birthweight neonates (less than 1500 gm) with confirmed PDA were randomly assigned in a double-blind fashion to receive standard indomethacin therapy (three doses), followed either by maintenance indomethacin therapy (0.2 mg/kg/day) for 5 days or by an equivalent volume of placebo for 5 days. Of the 20 infants who received maintenance indomethacin therapy, two (10%) required additional therapy and one of these required surgical ligation. Of the 19 infants who received only the first three indomethacin doses, nine (47%) required additional therapy for PDA (p less than 0.05) and seven of these had a ligation (p less than 0.05). We conclude that maintenance indomethacin therapy, in comparison with short-term indomethacin therapy, decreases the incidence of surgical PDA ligations, eliminates most PDA recurrences, and does not increase toxic effects of indomethacin in the low birth weight infant with PDA.

Prophylactic indomethacin has short-term benefits for preterm infants including a reduction in the incidence of symptomatic PDA, PDA surgical ligation, and severe intraventricular haemorrhage. However, there is no evidence of effect on mortality or neurodevelopment.


Comparison of a hydrocolloid dressing and silver sulfadiazine cream in the outpatient management of second-degree burns.

A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds.

Procutase versus 1% silver sulphadiazine in the treatment of minor burns.

Biobrane versus 1% silver sulfadiazine in second-degree pediatric burns.

Safety and efficacy of a new synthetic burn dressing: a multicenter study.

A comparison of topical Phenytoin with Silverex in the treatment of superficial dermal burn wounds.

A comparative controlled trial of intralesionally-administered zinc sulphate, hypertonic sodium chloride and pentavalent antimony compound against acute cutaneous leishmaniasis.

Treatment of second degree facial burns with allografts--preliminary results.

Comparison of efficacy of 1% silver sulfadiazine and Acticoat for treatment of partial-thickness burn wounds.

Abstract: The purpose of this prospective randomized study was to evaluate the use of an occlusive hydrocolloid dressing (Duoderm hydroactive, Squibb) and silver sulfadiazine (Silvadene, Marion) cream in the outpatient management of second-degree burns. The inclusion criteria consisted of burns less than 15% total body surface area that were evaluated within 24 hours of injury and did not require hospital admission. Fifty patients were randomly assigned after having been screened through a list of seven exclusion criteria. On initial evaluation the burns were photographed and screened for causative agent, location, size, depth, tetanus status, and presence of associated burns and injuries. Patients were seen in followup at least biweekly and evaluated for wound bed healing, wound margin healing, pain, number of dressing changes between visits, and ease of dressing application and removal. On final evaluation the burns were photographed and inspected for appearance of the healed burn, repigmentation, wound contraction, approximate time for dressing change, patient compliance, limitation of activity, overall impression of the treatment, and number of days for complete healing. Results were compared using a two-tailed t-test with p less than 0.01. Both groups were statistically similar in age, sex, and size. Duoderm-treated burns had statistically significantly better wound healing, repigmentation, less pain, fewer dressing changes, less time for dressing changes, and less cost. Duoderm-treated patients had statistically significantly less limitation of activity, better patient compliance, greater patient comfort, better overall acceptance, and felt the treatment was more aesthetically pleasing. The results reveal that the Duoderm Hydroactive dressings are superior to Silvadene cream in the outpatient management of second-degree burns.

Abstract: A new silver-coating technology was developed to prevent wound adhesion, limit nosocomial infection, control bacterial growth, and facilitate burn wound care through a silver-coated dressing material. For the purposes of this article, Acticoat (Westaim Biomedical Inc, Fort Saskatchawan, Alberta, Canada) silver-coated dressing was used. After in vitro and in vivo studies, a randomized, prospective clinical study was performed to assess the efficacy and ease of use of Acticoat dressing as compared with the efficacy and ease of our institution's standard burn wound care. Thirty burn patients with symmetric wounds were randomized to be treated with either 0.5% silver nitrate solution or Acticoat silver-coated dressing. The dressing was evaluated on the basis of overall patient comfort, ease of use for the wound care provider, and level of antimicrobial effectiveness. Wound pain was rated by the patient using a visual analog scale during dressing removal, application, and 2 hours after application. Ease of use was rated by the nurse providing wound care. Antimicrobial effectiveness was evaluated by quantitative burn wound biopsies performed before and at the end of treatment. Patients found dressing removal less painful with Acticoat than with silver nitrate, but they found the pain to be comparable during application and 2 hours after application. According to the nurses, there was no statistically significant difference in the ease of use. The frequency of burn wound sepsis (> 10(5) organisms per gram of tissue) was less in Acticoat-treated wounds than in those treated with silver nitrate (5 vs 16). Secondary bacteremias arising from infected burn wounds were also less frequent with Acticoat than with silver nitrate-treated wounds (1 vs 5). Acticoat dressing offers a new form of dressing for the burn wound, but it requires further investigation with greater numbers of patients in a larger number of centers and in different phases of burn wound care.

Abstract:
The purpose of this randomised comparative study was to evaluate the use of silver sulphadiazine (SSD) 1% cream (Group A) with the use of Procutase (Group B) in treating burns with a TBSA <10% and a depth not greater than 2nd degree burns and thus suitable for outpatient management. The two groups were similar in age, gender, race, and extent of burn. Procutase is an ionic hydrogel composed of natural hydrophilic polymers in an active ionic solution with an inhibitor of matrix metalloproteinases MMP-1, -3 and -9 (collagenase/gelatinase). Subjects were seen in follow-up biweekly, and wounds of patients in SSD group were compared with those of Procutase group for healing time, pain score at dressing change, compliance with therapy and complication rate. The result of this study showed that Procutase treated patients had statistically significantly less pain and shorter wound healing time. Procutase can be used successfully in patients with burns that do not require hospital admission.
                2009 Elsevier Ltd and ISBI. All rights reserved.

Abstract: Partial-thickness burns in children have been treated for many years by daily, painful tubbing, washing, and cleansing of the burn wound, followed by topical application of antimicrobial creams. Pain and impaired wound healing are the main problems. We hypothesized that the treatment of second-degree burns with Biobrane is superior to topical treatment. Twenty pediatric patients were prospectively randomized in two groups to compare the efficacy of Biobrane versus 1% silver sulfadiazine. The rest of the routine clinical protocols were followed in both groups. Demographic data, wound healing time, length of hospital stay, pain assessments and pain medication requirements, and infection were analyzed and compared. Main outcome measures included pain, pain medication requirements, wound healing time, length of hospital stay, and infection. The application of Biobrane to partial-thickness burns proved to be superior to the topical treatment. Patients included in the biosynthetic temporary cover group presented with less pain and required less pain medication. Length of hospital stay and wound healing time were also significantly shorter in the Biobrane group. None of the patients in either group presented with wound infection or needed skin autografting. In conclusion, the treatment of partial-thickness burns with Biobrane is superior to topical therapy with 1% silver sulfadiazine. Pain, pain medication requirements, wound healing time, and length of hospital stay are significantly reduced.

Abstract: A three-tiered, multicenter study evaluated the safety and efficacy of a new synthetic dressing for burn injuries. The first tier compared use of the test dressing with use of a conventional topical chemotherapeutic agent; the test dressing afforded greater patient comfort, equivalent control of bacterial growth, less frequent dressing change, and possibly faster reepithelialization. Drawbacks included difficulty of application, poor adherence during the first 24 hours after injury, frequent necessity to repair cracks and fissures, and inability to easily monitor burn wounds for bacterial growth. Subsequent tiers were noncomparative but included patients with more severe injuries. The test dressing may be useful in treating superficial and moderate second-degree burns of less than 20% of the total body surface area and possibly in treating iatrogenic "burn" wounds such as donor sites. Its use on third-degree burns is not recommended.

Abstract:
To compare topical diphenylhydantion (Phenytoin) with silver sulphadiazine/chlorhexidine (Silverex) in terms of rate of wound healing, analgesic and antibacterial properties in small to moderate-sized (< 30% TBSA) superficial dermal (second degree) burn wounds.
                A prospective randomized controlled study.
                Surgical wards, Muhimbili National Hospital from July 2000 to February 2001.
                Sixty four patients with acute burns, 32 in each group.
                Study group treated by sprinkling Phenytoin powder and control group by sprinkling Silverex powder on the wounds for 14 days or until the wound epithelialised or was ready for skin grafting. The data collected included demographic characteristics of patients, aetiology of burn injury, circumstances of injury, site and extent of burns, pus discharge and smell from the wound, pain and discomfort from the wound, bacterial cultures of wound swabs, rate of reduction in wound size and outcome of treatment.
                The study enrolled 33 male and 31 female patients, 69% being children under five years of age. Hot liquids (80%) and open flames (20%) were the only causes of burns. In 97% of patients injury was due to domestic accidents. In half of the patients burns involved the trunk, and 52% of all patients had less than 15% total body surface burnt. Pus discharge was recorded in 59% of Phenytoin-treated and 75% in Silverex-treated patients while foul smell was noted in 19% and 31% of cases respectively. There were more negative bacterial wound cultures in Phenytoin-than Silverex-treated wounds on day five and day 10 of treatment, the difference being statistically significant (p < 0.01 and 0.001 respectively). There was also a statistically significant difference in wound pain in favour of Phenytoin (p < 0.01). There was no statistically significant difference in the rate of healing in the two groups.
                Phenytoin is a cheap and easy-to-use medicament, effective in suppressing burn wound bacteria and relieving pain thereby promoting healing, and may be advocated for the purpose in resource-scarce environments.

Abstract: A comparative clinical trial between two newly introduced intralesional treatments for acute leishmaniasis and the established treatment of intralesionally-administered pentavalent antimony compounds was performed. Treatments were allocated randomly to a total of 63 patients who received 2% zinc sulphate, 7% sodium chloride solutions or sodium stibogluconate intralesionally. A number of patients were left without treatment as controls. Patients were followed-up for 45 days, the results showing that the three treatments gave comparable cure rates by the end of the follow-up period. However, zinc sulphate gave a high cure rate (94.8%) usually with a single injection.

Abstract: Facial burns are very common and have significant clinical impact. However, the treatment regimen for superficial to deep facial burns is not well defined. The purpose of this study was to investigate the effects of cadaver skin grafting in deep partial thickness facial burns in comparison to standard care. In a prospective open study design severely injured patients with superficial and deep partial thickness burns were randomized into the group receiving open treatment with silversulfadiazine (standard n=5) or into the group receiving early superficial debridement followed by coverage with glycerolized cadaver skin (n=5). The outcome measures were time and quality of wound healing, and incidence of hypertrophic scarring at 3 and 6 months post burn. There were no significant differences in demographics between groups. In the group treated with the allogenic material time to reepithelialization was 10.5 days, while it was 12.4 days in the silversulfadiazine group (p<0.05). Scar quality was found to be significantly improved in the allogenic treatment group. Three and 6 months postburn there were no patients with significant hypertrophic scarring in the allogenic group while there were two patients who developed hypertrophic scars in the silversulfadiazine group (p<0.05). In this study, we demonstrated that glyzerolized cadaver allograft skin represents a superior biological dressing for shallow and deep partial thickness facial burns. This is in concordance with other reports on scalds. It would be worthwhile to perform more clinical studies with a larger number of patients to further evaluate the effect and function of allogenic skin for facial burns.

Abstract:
Acticoat (Smith & Nephew, Hull, UK) is a silver-coated dressing reported to reduce infection and exhibit antimicrobial activity in wounds.
                The purpose of the present study was to compare the efficacy ofacticoat and 1% silver sulfadiazine (1% AgSD) for treatment of partial thickness burn wounds.
                The authors reviewed 50 patients who had partial thickness burn wounds less than 25% admitted to Siriraj Burn Unit from May 2002 to September 2005. All patients were divided into 2 groups: the acticoat treated group (25 patients) and the 1% silver sulfadiazine treated group (25 patients). The 2 groups were compared for the etiology of burn wound, demographic data including age, sex, % Total Body Surface Area burn (TBSA%), cultured organisms, wound infection and outcome of Length Of hospital Stay (LOS) and level of pain.
                The authors found no significant differences in age, TBSA (%) between both groups. 7 patients (28%) developed wound infection. There were no differences in wound infection and LOS between both groups (p > 0.05). All of the patients who developed wound infection responded well to targeted topical and systemic antibiotic treatment. The 1% AgSD treated group (6 of 25, 24%) obtained more split thickness skin graft to close the granulation defects compared to patients who were treated with acticoat (4 of 25, 16%) but no statistical significance, p = 0.32). Average pain scores in the acticoat treated groups were significantly lower than the 1% AgSD treated group (4 +/- 0.6 versus 5 +/- 0.7, respectively).
                The present study confirms the efficacy of acticoat treatment in partial thickness burn wound. The authors conclude that acticoat has an advantage of limiting the frequency of replacement of the dressing and provides a less painful alternative to wound care with 1% AgSD with comparable incidence of burn wound infection. This is due to its long wear time and the ease of application and removal.

First aid for phosphorus burns involves the common sense measures of acting promptly to remove the patient's clothes, irrigating the wound(s) with water or saline continuously, and removing phosphorus particles. There is no evidence that using copper sulphate to assist visualisation of phosphorus particles for removal is associated with better outcome, and some evidence that systemic absorption of copper sulphate may be harmful. We have so far been unable to identify any other comparisons relevant to informing other aspects of the care of patients with phosphorus burns. Future versions of this review will take account of information in articles published in languages other than English, which may contain additional evidence based on treatment comparisons.