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Gartner: Top 10 Strategic Technologies for 2010

Last month, Gartner published its annual list of Top Strategic Technologies.   Gartner defines a strategic technology as one with the potential for significant impact on the enterprise in the next three years.  Factors that denote significant impact include a high potential for disruption to IT or the business, the need for a major dollar investment, or the risk of being late to adopt.

The 2010 list they recently published goes like this…

  1. Cloud Computing
  2. Advanced Analytics
  3. Client Computing
  4. IT for Green
  5. Reshaping the Data Center
  6. Social Computing
  7. Security – Activity Monitoring
  8. Flash Memory
  9. Virtualization for Availability
  10. Mobile Applications

I found a pdf file of the Gartner presentation of these trends at this URL (valid as of Nov. 23).  For more information, you can read the Gartner Press Release “Gartner Identifies the Top 10 Strategic Technologies for 2010” or check out the video below.

You can see the previous lists for 2009 and 2008

One thought on “Gartner: Top 10 Strategic Technologies for 2010

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Friday February 24, 2017
Back to Teen Books
Just Believe It
Just Believe It: Faith in the Real Stuff
(A daily devotional on the book of James)

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This is a day-to-day devotional study on the book of James. This fun, fast-paced book gives you hands-on advice from a very down-to-earth disciple. Lively teaching and great questions at the end of each section make it easy to… shape up your spiritual life…trim down temptations…tighten up your tongue…buff up your spirit …by putting your faith into action.

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Thread: Engine Oil Q!
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Old 09-04-2012, 11:13 AM
bimmerfan52 bimmerfan52 is offline
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Originally Posted by kskane View Post
Did the oil change service today using Castrol Edge Titanium 0W40 oil and BMW oil filter after 11K's and the oil that came out was BLACK as......

Do post which other non BMW oil do anyone uses in there car? I am interested.

Also, changing the oil filter twice/third in one oil change is a a good idea? (I just want to make sure there is sludge in the engine, that I am suspecting).
If you are actually collecting enough contaminants in your filter at say 2000 kilometers to warrant changing it, then there is a lot more suspended in your oil. If your engine has that much sludge the new oil may use half of some of its additives (dispersants and detergents) in the first 100 miles as it is fighting all of the built up contaminants. Change the oil with the filter.

If you are curious try one very short oil change (say 3500 kilometers) where you change both the oil and filter. Once drained you can cut the filter open and see what you find.

You can also send a sample of the 3500K oil into a lab for analysis. This generally costs about $50. This will tell you if the new oil took a beating from existing sludge and can help you decide your future drain intervals.

If the oil comes back looking pretty good then you will be safe going onto drain intervals of say 8500 to 10000 kilometers.

Again, if you are not experiencing any side effects of excessive sludge (running hot, sluggish acceleration) then I wouldn't worry too much. Change the oil and enjoy driving the car.

RE: Oil - I use Mobil 1 0W-40 and Hengst Filters
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Old 10-16-2012, 01:42 PM
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Originally Posted by Ucla95 View Post
My car continues to gather dust at the VPC.
Sorry to hear. Do you know if the pumps are at the VPC or are they still waiting on parts?
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Old 12-19-2012, 01:26 PM
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Originally Posted by cordoor View Post
I would very much prefer free market forces to change people's minds about buying huge SUV's than government influencing the market with some kind of a tax.

If the availability of oil weakens, the price will go up. If it goes up high enough, people will change their spending habits. There is no need for government to intervene.

I'm surrounded by mouthbreathers in lifted F250's that maybe actually tow something once per year and I'm sure just blame everyone else if fuel prices creep up, there is no freaking way on earth these people would ever ever freaking ever buy a "gay" Toyota Prius or any other economical car. Good luck.
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2001 E46 330Ci Sport, Steel Grey, 5-speed MT....and more

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Old 02-08-2013, 06:16 AM
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Originally Posted by Kevin Bowen View Post
How many miles were on your tranny. Mine is doing the same thin with only 50k miles on it. Are these solenoids upgraded / better than originals, or will the same problem come back over time
The tranny had roughly 45K on it whenI replaced the solenoids. It was a replacement tranny because I had the same issues from the original tranny. Since replacing the solenoids I have not had any issues whatsoever. I have yet to log enough miles to provide accurate feedback on whether the issue will reoccur.
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Navigation Links
Ric Weiland Leaves $65 Million to Support Gay Rights and HIV/AIDS Organizations

Largest Single Bequest Ever to the Lesbian, Gay, Bisexual and Transgender

(LGBT) Movement By Early Microsoft Employee

Pride Foundation to Distribute Weiland's Groundbreaking Bequest

SEATTLE, Feb. 24 /PRNewswire/ -- Pride Foundation of Seattle is honored to announce the establishment of a sizable new fund from the estate of Ric Weiland. Mr. Weiland's gift of $65 million is the largest single bequest ever to the lesbian, gay, bisexual and transgender (LGBT) movement. As one of Microsoft's first employees, having joined the company that was started by two of his high school classmates Bill Gates and Paul Allen, Ric Weiland used philanthropy to strengthen his community by giving generously to many organizations. When Weiland died in June of 2006, he made sure that the work he cared about in his life would continue, leaving the vast majority of his estate to LGBT, HIV/AIDS, environmental and education organizations. Pride Foundation is honored to be one of the organizations receiving a tremendous bequest from Ric Weiland for our grants, scholarships and leadership development work and for distribution to organizations working to advance LGBT equality.

"Ric was one of Pride Foundation's closest supporters, not just as a donor, but as a board member and volunteer," said Audrey Haberman, executive director of the Pride Foundation. "All of us feel such a tremendous loss with him gone. Ric's bequest will do what he always wanted-inspire others to give to the causes they care about to the full extent that they can."

A modest man, Weiland could have easily started his own foundation, but chose instead to work through existing national and local organizations. He was known for carefully vetting the charities he supported and shunning public accolades. Weiland intended his gifts to inspire people to work together for positive change and to strengthen the communities that they touched.

"Ric was a good friend, a terrific computer programmer and a very generous man," said Paul G. Allen, co-founder of Microsoft and friend of Weiland. "His gift to the Pride Foundation demonstrates his compassion and dedication to the community, and I'm very proud to have had him as a friend. He will be sorely missed but his legacy lives on through the work of Pride and the charitable organizations it supports."

Through his estate, Weiland established a fund at Pride Foundation that will provide $46 million over the next eight years to 10 national LGBT and HIV/AIDS organizations that he personally selected. In addition, he bequeathed $19 million directly to Pride Foundation for our scholarships and grants supporting the Northwest's LGBT community.

The following organizations will be receiving funding from the Weiland Designated Fund at Pride Foundation:

-- amfAR, The Foundation for AIDS Research

-- Gay & Lesbian Alliance Against Defamation (GLAAD)

-- Gay, Lesbian, and Straight Education Network (GLSEN)

-- In The Life

-- International Gay and Lesbian Human Rights Commission (IGLHRC)

-- Lambda Legal

-- National Gay and Lesbian Task Force

-- Parents, Families and Friends of Lesbians and Gays (PFLAG)

-- Project Inform

-- Servicemembers Legal Defense Network

"Ric gave scores of LGBT groups significant resources to achieve real change during his lifetime. He did not seek the spotlight -- or even acknowledgement -- as he gave away tens of millions of dollars," said Urvashi Vaid, executive director of the national Arcus Foundation, who also knew Ric as a friend. "With this extraordinary gift, Ric's legacy challenges each of us to commit more fully to our own community and to realize that there is much more still to be done."

Ric Weiland died in June of 2006, at the age of 53, committing suicide after struggling with depression. He is survived by his partner, Mike Schaefer of Seattle and his nieces and nephews.

About the Pride Foundation

Pride Foundation is a community foundation serving the Northwest's lesbian, gay, bisexual and transgender community. Pride Foundation makes grants to organizations and gives educational scholarships to students in Alaska, Idaho, Montana, Oregon and Washington. Founded in 1985, Pride Foundation has given more than $7.2 million to over 500 organizations and 522 students in an effort to strengthen the LGBT community. To learn more about Pride Foundation and the 10 beneficiaries of the Weiland Designated Fund, please visit

SOURCE Pride Foundation
Copyright©2008 PR Newswire.
All rights reserved

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Navigation Links
Fuse Science Partners With the New England Consulting Group to Advance Technology Licensing Efforts in Pharmaceutical and OTC Categories

AVENTURA, Fla., Aug. 10, 2011 /PRNewswire/ -- Double Eagle Holdings, Ltd. (OTCQB: DEGH), announced today that it has retained The New England Consulting Group (NECG) in a strategic partnership to advance licensing efforts for the company's proprietary technology throughout the pharmaceutical and over-the-counter (OTC) markets. Double Eagle Holdings is the parent company of Fuse Science, Inc. (, the developer of new, proprietary technologies poised to redefine how consumers receive energy, medicines, vitamins and minerals.

Fuse Science has successfully developed and maintains the rights to sublingual, buccal, and transdermal delivery systems for bioactive agents that can now, for the first time, effectively encapsulate and charge many varying molecules in order to produce complete product formulations which can bypass the gastrointestinal tract and enter the blood stream directly.

"Our proprietary technology effectively penetrates the mucosa and epithelium to achieve complete and enhanced absorption, and it is our firm belief that at this moment we can deliver a wide range of product formulations via these delivery systems," said Rob Davidson, Chief Scientific Officer at Fuse Science.

"We have high confidence that our proprietary technology can effectively produce aspirin, OTC medications, energy and electrolyte products, sleep aids, appetite suppressants, pharmaceutical medications including enhancement products like Viagra and Cialis, along with vitamins and complex nutrition products – it is easy to understand that we must aggressively advance our licensing efforts with the leading companies in these categories," said Brian Tuffin, President and Chief Operating Officer. "Our deliberate strategy is to open licensing discussions with the number 1 and 2 brands in each respective category, and our partnership with The New England Consulting Group is a key enabler to accelerate this effort."

Founded in 1981 and headquartered in Westport, CT, The New England Consulting Group ( is a global leader in marketing and management consulting, providing strategic counsel and business development services to the world's largest and most successful companies.

"After thoroughly reviewing the Fuse Science platform, we believe this proprietary technology will change the face of many major categories of products that we consume each day," said Gaurav Kapoor, Managing Partner and Principal at NECG. "Through our extensive work with the leaders of industry in these categories, we are confident that this partnership has the ability to open new doors of development and consumer satisfaction and we are excited to be working with the Fuse Science team."

About Double Eagle Holdings
Double Eagle Holdings (OTCQB: is the holding company of Fuse Science, Inc., an innovative consumer products company based in Aventura, Florida. Fuse Science is the developer of patent-pending conveyance technologies poised to redefine how consumers receive energy, medicines, vitamins and minerals, delivering their benefits faster and more effectively than ever before. Information about Fuse Science is available online at or by calling 305-503-FUSE (3873).

Safe Harbor Statement: Certain statements and information included in this release may constitute "forward-looking statements" as defined in the Federal Private Securities Litigation Reform Act of 1995. Such forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of the company to be materially different from any future results, performance or achievements expressed or implied in such statements. Additional discussion of factors that could cause actual results to differ materially from management's projections, estimates and expectations is contained in the company's SEC filings. The company assumes no obligation to update any forward-looking statements as a result of new information, future events or developments, except as required by federal securities laws.

SOURCE Double Eagle Holdings, Ltd.
Copyright©2010 PR Newswire.
All rights reserved

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text:
RAPD Problems - Control lanes with bands

ANTHONY WILSON 002233w at axe.acadiau.ca
Thu Jul 6 09:07:54 EST 1995

   I've been performing RAPD reactions using primers from the UBC lab
and have been running a control with the same stock as my tests (Primer,
taq, buffer, dNTPs, H20) replacing the DNA with sterilized water, yet I am
consistently getting banding patterns in these lanes WITHOUT DNA...  I have
replaced the H20, dNTPs, taq and buffer and yet the bands are as strong as
ever!  Is this a common setup for a control lane?

   These banding patterns differ from reaction to reaction and from primer
to primer, yet bands appear in control lanes even when some of the test
lanes are clean...  Has anyone had any similar experiences and/or any
suggestions as to where in the protocol this error might be introduced??

   Any help would be greatly appreciated.

Tony Wilson

More information about the Methods mailing list


text:
Problem area wetland

problem area wetland

(Science: ecology) A wetland that is difficult to identify because it may lack indicators of wetland hydrology and/or hydric soils, or its dominant plant species are more common of nonwetlands.

Retrieved from ""
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Please contribute to this project, if you have more information about this term feel free to edit this page.


text:
Document Detail

Biliary obstruction in infants with cystic fibrosis requiring Kasai portoenterostomy.
MedLine Citation:
PMID:  9044117     Owner:  NLM     Status:  MEDLINE
Cystic fibrosis is associated with an inspissated bile syndrome producing cholestasis secondary to plugging of macroscopically normal bile ducts. In extreme neonatal forms, with early profound intrahepatic cholestasis, the process can be associated with a marked decrease in ductal diameter, varying from hypoplasia to atresia. From 1990 to 1995 three infants were identified with cystic fibrosis, persistent jaundice, and complete absence of biliary excretion despite expectant and conservative treatment including choleretics and surgical biliary irrigation. Abdominal ultrasounds showed contracted gallbladders and no evidence of dilated ducts. Liver biopsy results in two infants showed portal fibrosis, paucity of bile ducts, and minimal inflammation. The third infant had moderate inflammation, bile duct replication, and plugging. Two infants had undergone intestinal resection followed by hyperalimenation for complications of meconium ileus in the newborn period. Surgical exploration was undertaken at 7 to 12 weeks of age. Gross findings were typical of biliary atresia with microgallbladders and nonpatency of the cystic duct. Cholangiograms failed to document ductal patency in two patients who were then treated with a Kasai portoenterostomy. The third infant had patent hypoplastic ducts and underwent only biliary irrigation. Although bile flow was transiently achieved, jaundice recurred, and at reexploration at 16 weeks of age a Kasai poroenterostomy was performed. Histological review of the biliary specimens showed microscopically patent ducts in two patients and proximal patency and distal atresia in the third. All the ducts had mural fibrosis with cystic changes. Bile drainage was achieved in each instance, although in one patient with hypoplastic ducts scant output of highly concentrated bile proved insufficient to arrest progressive liver failure. The subsequent two patients responded with resolution of hyperbilirubinemia and normalization of liver function. They remain free of biliary complications at 30 and 40 months postoperatively. This manifestation of cystic fibrosis in infants is suggested by prolonged jaundice unresponsive to choleretics, nondilated bile ducts and gallbladder on ultrasound, absent biliary excretion on nuclear scan, and characteristic liver biopsy. Exploration is warranted, and discovery of atrophic bile ducts may be best managed with reconstruction.
S K Greenholz; B Krishnadasan; C Marr; R Cannon
Related Documents :
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Publication Detail:
Type:  Case Reports; Journal Article
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  32     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1997 Feb
Date Detail:
Created Date:  1997-05-02     Completed Date:  1997-05-02     Revised Date:  2004-11-17
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES
Other Details:
Languages:  eng     Pagination:  175-9; discussion 179-80     Citation Subset:  IM
Division of Pediatric Surgery, University of California, Davis Medical Center, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biliary Atresia / complications,  surgery*
Cystic Fibrosis / complications*
Fatal Outcome
Gallbladder / pathology
Hepatic Duct, Common / pathology
Intestinal Obstruction / complications
Jaundice / etiology
Portoenterostomy, Hepatic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biliary atresia: should all patients undergo a portoenterostomy?
Next Document:  Ventricular cholecystic shunts in children.


text:
Document Detail

Crevicular fluid glutathione levels in periodontitis and the effect of non-surgical therapy.
MedLine Citation:
PMID:  19968740     Owner:  NLM     Status:  MEDLINE
AIM: To quantify reduced and oxidized glutathione (GSH and GSSG) levels in gingival crevicular fluid (GCF) of periodontitis patients pre-therapy (versus periodontally healthy controls) and ascertain whether successful non-surgical therapy alters glutathione levels. MATERIALS AND METHODS: Thirty-second GCF samples (6/subject) were collected on Periopaper() strips from starved, non-smokers (n=20; mean age 43.6 years) with chronic periodontitis, before and 3 months after non-surgical therapy, and periodontally healthy, age- and gender-matched controls (n=20). GSH and GSSG levels were determined using reversed-phase high-performance liquid chromatography with fluorescence detection. RESULTS: Lower concentrations of GSH (p<0.01) and GSSG (p<0.05) were detected in GCF from patients (pre- and post-therapy) than controls and treatment had no significant effect. Amounts per 30-second sample did not differ between patients and controls. However, the amount of GSSG per 30-second sample decreased in patients after therapy (p<0.05). Consequently, therapy increased the GSH:GSSG ratio (p<0.05) in patients compared with the controls (p=0.8). CONCLUSION: These data demonstrate high concentrations of GSH within GCF, which are compromised in chronic periodontitis. While therapy does not appear to fully restore GSH concentrations in GCF, it does restore the redox balance (GSH:GSSG ratio), suggesting that the abnormal redox balance arises secondary to oxidative stress resulting from periodontal inflammation.
Melissa M Grant; Gareth R Brock; John B Matthews; Iain L C Chapple
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-24
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  37     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2010 Jan
Date Detail:
Created Date:  2010-01-25     Completed Date:  2010-04-06     Revised Date:  -
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark
Other Details:
Languages:  eng     Pagination:  17-23     Citation Subset:  D; IM
Periodontology Research Group, School of Dentistry, University of Birmingham, Birmingham, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alveolar Bone Loss / metabolism,  therapy
Case-Control Studies
Chronic Periodontitis / metabolism*,  therapy
Dental Scaling
Follow-Up Studies
Gingival Crevicular Fluid / chemistry*
Gingival Hemorrhage / metabolism,  therapy
Glutathione / analysis*
Glutathione Disulfide / analysis
Periodontal Attachment Loss / metabolism,  therapy
Periodontal Pocket / metabolism,  therapy
Root Planing
Subgingival Curettage
Reg. No./Substance:
27025-41-8/Glutathione Disulfide; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of cleft lip on socio-emotional functioning in school-aged children.
Next Document:  Effect of periodontal treatment on metabolic control, systemic inflammation and cytokines in patient...


text:
Document Detail

Direct contact with mesenchymal stromal cells affects migratory behavior and gene expression profile of CD133+ hematopoietic stem cells during ex vivo expansion.
MedLine Citation:
PMID:  19216019     Owner:  NLM     Status:  MEDLINE
OBJECTIVE: To investigate the impact of direct contact between mesenchymal stromal cells (MSCs) and CD133(+) hematopoietic stem cells in terms of expansion potential, differentiation, migratory capacity, and gene expression profile. MATERIALS AND METHODS: CD133(+)-purified hematopoietic progenitor cells were cultured for 7 days on subconfluent MSCs supplemented with growth-factor-containing medium. After ex vivo expansion, nonadherent and adherent cells were collected and analyzed separately. RESULTS: The adherent cell population was less differentiated than the nonadherent fraction. CXCR4 was upregulated in the adherent fraction, which was associated with a higher migration capacity toward a stromal cell-derived factor-1 gradient. Colony-forming unit granulocyte-macrophage and long-term culture-initiation cell assays demonstrated a higher clonogenicity and repopulating capacity of the adherent fraction. Genes involved in adhesion, cell-cycle control, motility, and self-renewal were more highly expressed in the adherent fraction. CONCLUSION: Adhesion and direct cell-to-cell contact with an MSC feeder layer supports ex vivo expansion, migratory potential, and stemness of CD133(+) hematopoietic progenitor cells.
Nael Alakel; Duohui Jing; Katrin Muller; Martin Bornhauser; Gerhard Ehninger; Rainer Ordemann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-12
Journal Detail:
Title:  Experimental hematology     Volume:  37     ISSN:  1873-2399     ISO Abbreviation:  Exp. Hematol.     Publication Date:  2009 Apr
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-04-09     Revised Date:  -
Medline Journal Info:
Nlm Unique ID:  0402313     Medline TA:  Exp Hematol     Country:  Netherlands
Other Details:
Languages:  eng     Pagination:  504-13     Citation Subset:  IM
Medizinische Klinik und Poliklinik I, University Hospital Carl-Gustav-Carus, Dresden, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigens, CD / metabolism*
Blotting, Western
Cell Adhesion
Cell Division / physiology
Cell Movement / physiology*
Flow Cytometry
Gene Expression Profiling*
Gene Expression Regulation*
Glycoproteins / metabolism*
Hematopoietic Stem Cells* / cytology,  metabolism
Mesenchymal Stem Cells / cytology,  metabolism*
Peptides / metabolism*
Stromal Cells / cytology,  metabolism*
Surface Properties
Reg. No./Substance:
0/AC133 antigen; 0/Antigens, CD; 0/Glycoproteins; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of custom adaptation and span-diameter ratio on the flexural properties of fiber-reinforc...
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text:
Document Detail

Utility of history and physical updates for ambulatory otolaryngic surgery.
MedLine Citation:
PMID:  17975507     Owner:  NLM     Status:  MEDLINE
OBJECTIVES/HYPOTHESIS: Preoperative assessment is intended to identify anesthetic risk and a patient's appropriateness to undergo a proposed surgery. The timing of these assessments varies among institutions. In our ambulatory surgery center, preoperative reassessments were initially performed within 30 days of surgery (group A). Recently, this changed to require reassessments within 7 days of surgery (group B). Now, the policy mandates a preoperative reassessment within 24 hours (group C). We evaluate whether there are differences in surgical cancellations based on these new reassessment intervals. STUDY DESIGN: Retrospective operative log and chart review. METHODS: We identified 1,108 cases representative of group A. The rate of surgical cancellations for this group was compared with that of the 3,705 cases in group B and the 1,060 cases in group C. Differences were evaluated with a chi test. RESULTS: Total cancellation rates for groups A, B, and C were 3.0%, 3.3%, and 3.9%, respectively (P = .51). Cancellations secondary to a history and physical examination findings during these preoperative reassessment periods were 0.81%, 0.38%, and 0.66% for groups A, B, and C, respectively (P = .15). CONCLUSIONS: Cancellation rates for patients undergoing ambulatory otolaryngic surgery based on preoperative reassessment intervals of 30 days, 7 days, and 24 hours were similar.
Scott L Lee; Salvatore Taliercio; Ashar Ata; Jessica Clayton; Steven M Parnes
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Publication Detail:
Type:  Journal Article
Journal Detail:
Title:  The Laryngoscope     Volume:  118     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2008 Jan
Date Detail:
Created Date:  2007-12-31     Completed Date:  2008-02-25     Revised Date:  -
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States
Other Details:
Languages:  eng     Pagination:  165-8     Citation Subset:  IM
Division of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 35 Hackett Boulevard, Albany, NY 12208, U.S.A.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ambulatory Surgical Procedures* / statistics & numerical data
Appointments and Schedules*
Medical History Taking*
Organizational Policy
Otorhinolaryngologic Surgical Procedures* / statistics & numerical data
Patient Dropouts / statistics & numerical data
Physical Examination*
Retrospective Studies
Surgicenters / organization & administration
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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text:
New Institute for Precision Medicine Created at Weill Cornell Medical College and NewYork-Presbyterian Hospital
1/31/2013 12:22:16 PM

NEW YORK (Jan. 31, 2013) -- Recognizing that medicine is not "one size fits all," Weill Cornell Medical College and NewYork-Presbyterian Hospital have created the pioneering Institute for Precision Medicine at Weill Cornell and NewYork-Presbyterian/Weill Cornell Medical Center. This new, cutting-edge translational medicine research hub will explore the new frontier of precision medicine, offering optimal targeted, individualized treatment based on each patient's genetic profile. The institute's new genomic research discoveries will help develop novel, personalized medical therapies to be tested in innovative clinical trials, while also building a comprehensive biobank to improve research and patient care.

The Institute for Precision Medicine will be led by Dr. Mark Rubin, a renowned pathologist and prostate cancer expert who uses whole genomic sequencing in his laboratory to investigate DNA mutations that lead to disease, particularly prostate cancer. Dr. Rubin currently serves as vice chair for experimental pathology, director of Translational Research Laboratory Services, the Homer T. Hirst III Professor of Oncology, professor of pathology and laboratory medicine and professor of pathology in urology at Weill Cornell and is a pathologist at NewYork-Presbyterian/Weill Cornell.

Dr. Rubin and his team seek to replace the traditional one-size-fits-all medicine paradigm with one that focuses on targeted, individualized patient care using a patient's own genetic profile and medical history. Physician-scientists at the institute will seek to precisely identify the genetic influencers of a patient's specific illness -- such as cancer, cardiovascular disease, neurodegenerative disease and others -- and use this genetic information to design a more-effective course of treatment that targets those specific contributing factors. Also, genomic analyses of tumor tissue will enable researchers to help patients with advanced disease and no current treatment options, as well as to isolate the causes of drug resistance in patients who stop responding to treatments, redirecting them to more successful therapies.

Preventive precision medicine will also be a key initiative at the institute, allowing physician-scientists to help identify a patient's risk of diseases and take necessary steps to aid in its prevention through medical treatment and/or lifestyle modification. In addition, the Institute for Precision Medicine will leverage an arsenal of innovative genomic sequencing, biobanking and bioinformatics technology to transform the existing paradigm for diagnosing and treating patients.

"This institute will revolutionize the way we treat disease, linking cutting-edge research and next-generation sequencing in the laboratory to the patient's bedside," Dr. Rubin says. "We will use advanced technology and the collective wealth of knowledge from our clinicians, basic scientists, pathologists, molecular biologists and computational biologists to pinpoint the molecular underpinnings of disease -- information that will spur the discovery of novel treatments and therapies. It's an exciting time to be involved in precision medicine and I look forward to advancing this game-changing field of medicine."

"Precision medicine is the future of medicine, and its application will help countless patients," says Dr. Laurie H. Glimcher, the Stephen and Suzanne Weiss Dean of Weill Cornell Medical College. "The Institute for Precision Medicine, with Dr. Rubin's expertise and strong leadership, will accelerate our understanding of the human genome, provide key insights into the causes of disease and enable our physician-scientists to translate this knowledge from the lab to the clinical setting to help deliver personalized treatments to the sickest of our patients."

Three main resources will facilitate the institute's groundbreaking precision medicine work: genomics sequencing, biobanking and bioinformatics. Weill Cornell and NewYork-Presbyterian will invest in state-of-the-art technology to conduct sequencing, a more expansive biobank for all patient specimens and tissue samples and dedicated bioinformaticians who will closely analyze patient data, searching for genetic mutations and other abnormalities to identify and target with treatment.

"The Institute for Precision Medicine will enable our doctors to tailor effective treatments for individual patients and also predict the diseases that are likely to affect a patient long before they develop," says Dr. Steven J. Corwin, CEO of NewYork-Presbyterian Hospital. "By harnessing the full potential of our enhanced understanding of the human genome, and extending its reach into the clinical realm, the institute will transform patient care at NewYork-Presbyterian/Weill Cornell Medical Center and beyond."

Dr. Rubin, the institute's inaugural director, is a board-certified pathologist and physician-scientist with specific expertise in genitourinary pathology and an internationally recognized leader in prostate cancer genomics and biomarker research. His groundbreaking research investigating molecular biomarkers distinguishing indolent from aggressive disease has led to landmark discoveries that revolutionized the understanding of prostate cancer's molecular underpinnings. This includes co-discovering two of the most common mutations in prostate cancer, the TMPRSS2-ETS rearrangements and SPOP mutations.

Dr. Rubin is one of the "Dream Team" principal investigators of a multi-institutional $10 million grant from Stand Up 2 Cancer (SU2C) and the Prostate Cancer Foundation, addressing patients with advanced prostate cancer through a multi-phase approach employing next generation sequencing to help inform the direction of future clinical trials. Additionally, Dr. Rubin serves as a co-principal investigator on the National Cancer Institute's (NCI) Early Detection Research Network (EDRN) Biomarker Discovery Laboratory and worked for many years as part of the NCI Prostate Cancer Specialized Programs of Research Excellence (SPORE).

Dr. Rubin has authored more than 275 peer-reviewed publications, predominantly in prostate cancer, and holds multiple NCI-funded grants in prostate cancer genomics and biomarker development. He is a member of the World Health Organization Prostate Cancer Tumor Classification and the Prostate TCGA (The Cancer Genome Atlas) Working Group. He serves as an ad hoc reviewer for multiple publications including Nature, Science, Cancer Cell, Cancer Discovery and the New England Journal of Medicine. Dr. Rubin also serves as the chair of the EDRN Prostate Cancer Working Group and is a member of the ERDN Steering Committee. He is active in the NCI/NHGRI-sponsored TCGA serving on the Prostate Cancer Working Group and he is an external advisor for the Canadian International Cancer Genome Consortium (ICGC). He served on the NCI Cancer Biomarker Study Section for five years and as an ad hoc reviewer for other NCI and international granting organizations.

Dr. Rubin is the recipient of the Arthur Purdy Stout Society of Surgical Pathologists Annual Prize (2003), the Young Investigator Award (2004) given by the United States and Canadian Academy of Pathology and the Huggins Medal (2012), the highest award bestowed by the Society of Urologic Oncology. Finally, Dr. Rubin was a co-team leader with his long-term collaborator, Arul M. Chinnaiyan (University of Michigan) for the first annual American Association of Cancer Research Team Science Award (2007) in recognition for their groundbreaking work on TMPRSS2-ETS fusion prostate cancer.

Weill Cornell Medical College

Weill Cornell Medical College, Cornell University's medical school located in New York City, is committed to excellence in research, teaching, patient care and the advancement of the art and science of medicine, locally, nationally and globally. Physicians and scientists of Weill Cornell Medical College are engaged in cutting-edge research from bench to bedside, aimed at unlocking mysteries of the human body in health and sickness and toward developing new treatments and prevention strategies. In its commitment to global health and education, Weill Cornell has a strong presence in places such as Qatar, Tanzania, Haiti, Brazil, Austria and Turkey. Through the historic Weill Cornell Medical College in Qatar, the Medical College is the first in the U.S. to offer its M.D. degree overseas. Weill Cornell is the birthplace of many medical advances -- including the development of the Pap test for cervical cancer, the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial of gene therapy for Parkinson's disease, and most recently, the world's first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. Weill Cornell Medical College is affiliated with NewYork-Presbyterian Hospital, where its faculty provides comprehensive patient care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Medical College is also affiliated with the Methodist Hospital in Houston. For more information, visit

NewYork-Presbyterian Hospital

NewYork-Presbyterian Hospital, based in New York City, is the nation's largest not-for-profit, non-sectarian hospital, with 2,409 beds. The Hospital has nearly 2 million inpatient and outpatient visits in a year, including 12,797 deliveries and 195,294 visits to its emergency departments. NewYork-Presbyterian's 6,144 affiliated physicians and 19,376 staff provide state-of-the-art inpatient, ambulatory and preventive care in all areas of medicine at five major centers: NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian Hospital/Columbia University Medical Center, NewYork-Presbyterian/Morgan Stanley Children’s Hospital, NewYork-Presbyterian/The Allen Hospital and NewYork-Presbyterian Hospital/Westchester Division. One of the most comprehensive health care institutions in the world, the Hospital is committed to excellence in patient care, research, education and community service. NewYork-Presbyterian is the #1 hospital in the New York metropolitan area and is consistently ranked among the best academic medical institutions in the nation, according to U.S.News & World Report. The Hospital has academic affiliations with two of the nation’s leading medical colleges: Weill Cornell Medical College and Columbia University College of Physicians and Surgeons. For more information, visit


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Protein Sciences Corporation Receives Approval From FDA For 2014/15 Formulation Of Flublok® Influenza Vaccine

7/8/2014 10:46:04 AM

free biotech news Get the latest biotech news where you want it. Sign up for the free GenePool newsletter today!

MERIDEN, Conn., July 8, 2014 /PRNewswire/ -- Protein Sciences Corporation announced today that the FDA has approved the Company's strain change amendment for its seasonal influenza vaccine, Flublok. Every year influenza vaccine manufacturers must receive approval from the Agency for changes they make to the upcoming season's manufacturing process and product formulation, as the influenza vaccine is adapted annually. Early approval for Flublok will enable delivery on time to healthcare providers in the fall. This is especially important for those that rely on Flublok's unique properties for protection from the flu; namely, that the vaccine is egg-free, highly pure and triple the strength compared to conventional influenza vaccines.

Protein Sciences Corporation is saving lives and improving health through the creation of innovative vaccines and biopharmaceuticals

President and CEO of Protein Sciences, Manon Cox said, "We anticipate having the first doses of Flublok available in September and the FDA's approval supports this timeline." She added, "We are still accepting orders for the fall and providers are encouraged to order through our distributors FFF Enterprises and ASD Healthcare."

About Protein Sciences
Protein Sciences is a vaccine development and protein production company that is dedicated to saving lives and improving health through the creation of innovative vaccines and biopharmaceuticals.

Flublok, the world's first recombinant protein-based vaccine for the prevention of seasonal influenza disease, was approved by FDA in January 2013. Flublok is the only flu vaccine made in a 100% egg-free system using modern cell culture technology, making it unnecessary to use an infectious influenza virus or antibiotics in manufacturing. Flublok is highly purified and does not contain any preservatives (e.g., thimerosal, a mercury derivative), egg proteins, gelatin or latex. In addition, Flublok is triple the strength of conventional influenza vaccines. Flublok is a perfect copy of the virus coat and is not subject to the egg-adapted mutations associated with low vaccine effectiveness (see Skowronski et al. (2014) PLOS ONE 9(3), e92153). We have filed for FDA approval of Flublok for ages 50 and above and expect to receive approval in time for the 2014/15 influenza season.

Healthcare professionals can order Flublok by contacting FFF Enterprises at 800-843-7477 or ASD Specialty Healthcare at 866-281-4FLU.

Learn more at www.proteinsciences.com and www.Flublok.com.

Flublok Safety Information
Flublok is approved for people 18-49 years old to prevent influenza disease. The most common side effect from Flublok is pain at the site of injection. Other side effects may occur and include fatigue, headache and muscle aches.

Flublok should not be administered to anyone with a severe allergic reaction (e.g., anaphylaxis) to any vaccine component.

Tell the doctor if you have ever experienced Guillain-Barre syndrome (severe muscle weakness) within 6 weeks of receipt of a previous dose of influenza vaccine. If you notice any other problems or symptoms following vaccination, please contact your healthcare professional immediately. Vaccination with Flublok may not protect all individuals.

Please see the complete Package Insert available at www.Flublok.com or call 203-686-0800 for more information.

Logo - http://photos.prnewswire.com/prnh/20140617/118909

SOURCE Protein Sciences Corporation

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Investors Continue Their Love Affair with Biotech

By Peter Winter

Monday, April 1, 2013

It has been a great quarter for public biotech companies as the sector continued to remain hot with investors. Large biotech companies, with market caps greater than $1 billion, collectively saw their share prices jump by an average of 21.5 percent in the first quarter.

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Dhanush's film gets re-titled

The title of Tamil actor Dhanush's new romantic-comedy 'Sotta Vazhakutty' has been changed to 'Naiyaandi', according to the director.

"It was earlier titled 'Sotta Vazhakutty' but now it has been changed to 'Naiyaandi' as I found this title more apt with the context of the film," A. Sarkunam said in a statement.

While Dhanush has been finalised to play the male lead, the makers are still hunting for a heroine. The film's other cast members include Parota Suri, Satyan and Lakshmy Ramakrishnan.

"We still are on the lookout for the female lead. The story tracks the events that pave way to hilarious moments in the love story between a lantern selling boy and a soon-to-be dentist girl," he added.

The primary shooting of the film is set to begin from February. It is produced by S. Kadiresan under the banner of Five Star Films.

Meanwhile, Dhanush is about to wrap up shooting for his debut Bollywood project "Raanjhnaa", opposite Sonam Kapoor.

Tag: dhanushs film gets retitled, south superstar, why this kolaveri di, dhanush, tamil actor, romantic comedy movie, naiyaandi, sotta

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Set Of 2 Enticing And Unique Styled Metal Candle Lantern by Benzara

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  • Metal Candle Lantern Dimensions (inches): L 14 x W 6 x H 19, L 12 x W 4 x H 14, L 17"H NO HANDLE, L 12"H NO HANDLE
  • Made of excellent quality materials
  • Durable and Creatively Designed

This set of 2 metal candle lanterns will enhance the beauty of any room or space. Made of quality materials this set of metal candle lanterns is durable and easy to maintain. These metallic lanterns are in trunk box shape with grills pattern on all four sides. It has sturdy legs and a beautiful metallic carving at the top with a circular handle in it which makes it easy to hold the lantern. These lanterns can be opened from top to place or replace candles inside it. The rays of light emitting from this set of lantern will fill the ambience with calmness and positive vibes. This metal candle lantern set looks exclusive and shall add touch of creativity to your room space. It will grab attention of many and also make you win appreciations from them. It can be gifted to your near and dear ones or those who appreciate creativity. It is a must accessory if you wish to add creativity to your room or any other space. Get this soon for your home.

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12-Point Fractional Combination Wrench, 1/2", Matte Finish by Blackhawk

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  • Flexible design allows wrench to work with many fastener heads.
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Flexibly crafted tool to work with many different fastener heads. Antislip design aids in grip and ensures better turning.

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Bistip is an innovative marketplace for peer to peer courier service. Bistip connects travelers and item lookers. Travelers get side income, item seekers get their wish.. See profile of ceha (Rachmawati sutarto) in Come and join Bistip to do transaction (buy, sell) with ceha (Rachmawati sutarto).

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Joseph DiBello
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Start with a skilled broker who has been through this before..call me

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Fedex Home delivery / they have alot of routes available / many here actually for sale

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I'll be happy to walk you through the entire process. Give me a call.

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Nobody answered yet, I would suggest you check with Francorp.com in Chicato. They have been in the franchising business for over 30 years. Why not go with the most experienced in the business.
If you are ready to compete with the "bigs" of the delivery business, they could help you best.
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Would-be KC terrorist gets conned by al-Qaeda

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Professional Services

It turns out that you just can’t trust terrorists these days. That’s the lesson learned by a Kansas City man with dreams of waging holy war, who sent money to Yemen, but ended up being conned by his al-Qaeda contact, The Kansas City Star reports.

Khalid Ouazzani is in a U.S. prison after pleading guilty to providing financial aid to al-Qaeda. But court documents show that the money he sent to Yemen, supposedly to help fund his military training, actually bought cars and other things for a pair of al-Qaeda con men, the report says.

U.S. officials arrested Oazzani for sending money to a terrorist group and he awaits sentencing. His contacts in Yemen were arrested and admitted to conning him and other Americans.

FBI officials cited alleged plans by Oazzani and another pair of U.S. men to study bombing the New York Stock Exchange as some of the beneficial intelligence gained by a top-secret program to track phone traffic.

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text:
Seventh Direction signs five-year lease on Hillside

Seventh Direction Inc., a drug and alcohol treatment center, is moving to 212 N. Hillside.

The company, owned by Randy Ecker and Diana Mershon, will move in January. The 5,600 square feet is twice the size of what Seventh Direction will be vacating in the Victor Place offices at 140 N. Hydraulic.

“We just got a little bigger and needed some more space,” says Ecker, who started the company about two years ago.

Ecker has four counselors on staff and one driver. His company has a niche in picking up patients for their treatment programs. Many of them can’t drive for various reasons.

“One of my goals is to take away people’s obstacles to treatment,” he says.

Ecker had worked about 20 years in drug and alcohol treatment at other clinics around Wichita before getting “brave” and starting his own company. He currently leases four suites at Victor Place.

The company is planning to move into the new space, which is being remodeled, on Jan. 7. The 212 N. Hillside building formerly was a dentist’s office. It also at one time was used by a credit union.

The owner is Douglas & Washington Development LLC. W.G. Farha is one of its owners. He didn’t return a call for comment.

Marty Gilchrist and Bradley Tidemann, of J.P. Weigand & Sons Inc., handled the lease deal.

Seventh Direction signed a five-year lease.

“We’re going to be around for a while,” Ecker says.


text:
LION'S SHARE Part With Bassist And Drummer, Pursue Outside Projects

Acclaimed Swedish melodic metal act LION'S SHARE have parted ways with Pontus Egberg (bass) and Johan Koleberg (drums) due to personal differences. Lars Chriss (guitar) and Tony Niva (vocals) will continue writing and demoing material for the group's fifth studio album, to be released sometime in late 2003 or early 2004. More information, including samples of the band's previous work, can be obtained via the group's official web site at this location.

In related news, COSMIC SPHERE, which features in its ranks Chriss, guitarist Antti Wirman (WARMEN, CRAYDAWN), bassist Tapio Oksanen (CRAYDAWN), drummer Kristian Enqvist (ex-RISING FAITH), and an American vocalist presently known only as "Shawn", are in the process of recording a two-song demo, the drum tracks for which were completed last month at KING DIAMOND guitarist Andy LaRocque's Los Angered Recordings studio outside Gothenburg, Sweden. Playing a musical style described as "heavy, energetic and melodic metal in the vein of IN FLAMES/SOILWORK," the group will be demoing more material in the weeks to come with a view towards releasing their debut album sometime in 2003.

In other related news, Chriss' TYKOON project, which he co-founded with guitarist Tommy Denander, are preparing to get back into songwriting mode over the course of the coming weeks. Plans still exist for the band — which also includes former GLORY/LION'S SHARE bassist Andy Loos — to participate in an upcoming KISS tribute CD containing only Unmasked-era songs, to which they will contribute a version of "Easy As It Seems".

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The surviving members of MELDRUM — the band formed by ex-PHANTOM BLUE guitarist Michelle Meldrum — will guest on Pirate Cat Radio 87.9 FM's "Hard Candy" today (September 27) at 4:00 p.m. PST.

You can listen to the program live via the Internet at this location.

A review of MELDRUM's September 15, 2009 concert at Whisky A Go Go in West Hollywood, California can be found at

Two full new songs from MELDRUM"A Toast To Romance" and "Blackened Blue" — are available for streaming at this location. Both tracks will appear on MELDRUM's forthcoming third album (for which Michelle recorded her tracks prior to her passing), "Lifer", which will be available for purchase through iTunes starting in October.

Michelle Meldrum died in May 2008 as a result of a cystic growth that had restricted oxygen and blood flow to her brain, rendering her braindead.

"Lifer" stands as a proud tribute to Michelle, who wrote the material for the CD with Hoglan, along with new members Laura Christine (bass) and Michele Madden (vocals).

"Lifer" is sonically different in direction than anything previously released by the band. With new life, and new talent, this album has carried the talents these four have to a higher level.

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WORLD UNDER BLOOD: Another Song Posted Online

WORLD UNDER BLOOD, the melodic death metal side project of CKY guitarist/vocalist Deron Miller, has uploaded its second completed track, "A God among the Waste", to its MySpace page.

WORLD UNDER BLOOD — which features Deron alongside drummer Tim Yeung (VITAL REMAINS, HATE ETERNAL) — recorded a total of three tracks during its recent sessions with engineer Logan Mader (MACHINE HEAD, SOULFLY): "Under the Autumn Low", "God Among the Waste", and "Dead and Still in Pain". Mixing duties are being handled by James Murphy (TESTAMENT, DEATH, OBITUARY).

Commented Miller: "James Murphy did an excellent job mixing this song, and I couldnt ask for it to be any better. This song truly exemplifies the unique dynamics of the band."

James Murphy stated: "WORLD UNDER BLOOD bridge a gap between genres that has never been bridged.... a few have tried with mixed results, but this is the first real resounding success of fusing brutal, blasting death metal with a melodic American rock vibe and it opens a door that will turn into a floodgate... I'm very happy to have been picked by Deron to mix this project ... he really pulls it together on this one musically and Tim's performance is stellar as well. Check it out!"

Deron Miller is widely credited for conceiving the long-awaited DEATH tribute project, "Within The Mind - In Homage To The Musical Legacy Of Chuck Schuldiner", as a means to help James Murphy raise money for his medical bills (Murphy is currently receiving treatment for a massive brain tumor with which he was diagnosed in August 2001).

The project, which has the blessing of the family of late DEATH mastermind Chuck Schuldiner (who passed away in December 2001 after a battle with pontine glioma, a rare type of brain tumor), has been in the works for the last couple of years and is expected to feature a number of special guest appearances, including those by members of SLIPKNOT, NEVERMORE, FEAR FACTORY, STATIC-X, and MALEVOLENT CREATION.

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Our Mission:

At Black Project, we focus crafting unique, delicious beers through research and development in spontaneous fermentation.

Black Project is the personal passion project of James Howat, owner and brewmaster of what was formerly Former Future Brewing Company. Black Project began production in January 2014 and won bronze medals for coolship ales (Category: Experimental, Subcategory: Wild Ales) at The Great American Beer Festival 2014 and 2015

All of our beers are fermented with microbes captured from the local environment via our coolship. We believe this creates a beer that is unrivaled in complexity. Our beers are intended to have a sense of place, terroir, no matter how hard one tried our beer could not be replicated outside of our brewery. In fact, our microbe cultures are purposefully allowed to evolve from batch to batch, creating variations and interesting twists from different releases of the same beer.

We are meticulous about designing recipes and processes that will allow nature to take over and create beers unrivaled in their beauty and complexity. Through experimentation and research we are continuously developing new and different techniques for use with wild and spontaneous fermentation.

We are not and do not have any intention of being a lambic brewery. We use science and experimentation to find which processes and ingredients we want to use that parallel traditional lambic producers, however - other the the use of a coolship - we maintain no strict adherence to tradition for tradition's sake. Spontaneous fermentation is merely a starting point and core of our process, from there James's research and development extends much beyond the scope of the great Belgian brewers and blenders.

We hope you enjoy our beers.

James Howat

Founder | Brewer | Blender


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gods-wrath1Milton Bradley is back, Carlos Marmol is back, and Derrek Lee is set to be back tonight.

But third baseman Aramis Ramirez is still out with a strained calf. And it’s not getting better.

“Ramirez was out here early to run, but he couldn’t accelerate at all,” Piniella told reporters. “The plan is for it to try it again Thursday, and if it isn’t better, we’ll have to weigh all our options.” Daily Herald.

So that means Ramirez is definitely out for tonight’s finale in Arizona. He’s a maybe for Thursday, but it isn’t difficult to read the tea leaves.

If Ramirez can’t go tomorrow, the Cubs will consider putting him on the disabled list. Ramirez has been out since Sunday, so if he does go on the disabled list, he’ll be eligible to come back a week from Monday.

Keep Reading BN ...

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Assuming the Chicago Cubs are able to move Milton Bradley, the plan is to slide Kosuke Fukudome back to right field, and fill the void in center field via free agency or a trade. Enter a couple meh rumors:

Free agent Marlon Byrd is certain to draw their interest.

Rudy Jaramillo, the Cubs’ new hitting coach, is a huge fan of Byrd’s from their three seasons together with the Rangers, according to major-league sources.

Byrd, 32, is seeking a multi-year contract after batting .283 for the Rangers last season with a career-high 20 homers and 89 RBIs.

Mike Cameron, 36, is another center fielder who could intrigue the Cubs. Cameron batted .250 with 24 homer and 70 RBIs for the Brewers last season, and his .795 OPS was nearly as high as Byrd’s .808. FOX Sports on MSN.

Cameron is likely to cost a great deal less than Byrd, but is just as likely to produce, and will play as good as or better defense than Byrd. All of that means that if the Cubs sign either of these guys, it will be Byrd. To a multi-year deal, when no other team was really bidding, and then he’ll regress like crazy. Because that’s what the Cubs do best.

Jim Hendry has been hot on Marlon Byrd’s trail before – even before he was a Ranger. Byrd has put together three straight solid offensive years, which not so coincidentally came in his three years in Texas. In case you were wondering, yes he does dominate at home: his career OPS+ at the Ballpark at Arlington is 133 (100 is average, 133 is very good), while his overall career OPS+ is just 99. That’s not good.

Mike Cameron, on the other hand, has hit consistently everywhere he’s played. He hasn’t had quite the recent seasons that Byrd has had, but he’s been more than solid – Cameron has not had an OPS+ under 100 in a decade. He’s also a three time Gold Glover.

Obviously, Cameron should be the choice here (if one of them must be), as he’ll come much cheaper and is more likely to not disappoint. So, again, expect to see Marlon Byrd in Cubbie Blue in 2010.

Keep Reading BN ...

« | »


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Colorado Avalanche

Why the Colorado Avalanche's Hot Start Is a Fluke

Jean-Sebastien Giguere has two shutouts in three starts this season. Can he maintain that level of play throughout the season?
Jean-Sebastien Giguere has two shutouts in three starts this season. Can he maintain that level of play throughout the season?Justin K. Aller/Getty Images
Dave LozoNHL National Lead WriterOctober 24, 2013

The Colorado Avalanche are one of the most surprising and positive stories of the NHL season’s first month. They are 8-1-0 under new coach Patrick Roy, whose club leads the Central Division and trails only the San Jose Sharks by one point in the overall standings.

It’s been a phenomenal stretch for the Avalanche, who have outscored opponents 28-12 and are 5-0 on the road. But based on their numbers in 2013-14—especially the goaltending numbers—there's almost zero chance this hot start is for real.

The Avalanche have a team save percentage of .961, the type of numbers you would post while playing a video game on the beginner level.

Starter Semyon Varlamov is 5-1-0 with a .950 save percentage and is finally looking like the goaltender the Avalanche felt was worthy of a first- and second-round draft pick when they acquired him from the Washington Capitals in 2011.

The only thing more unexpected than Varlamov’s dominance has been the performance of 36-year-old backup Jean-Sebastien Giguere. He is 3-0-0 with two shutouts and a .981 save percentage.

Amazingly, the only two goals he has allowed this season were against the Buffalo Sabres, who have zero regulation/OT wins and are averaging 1.20 goals per game.

Whether you’re a proponent of hockey’s advanced, fancy statistics or you prefer to let your eyes and gut tell you how to feel about things, there’s just no way you can expect Varlamov and Giguere to continue at this pace when they are facing an average of 33.8 shots per game.

Perhaps the best case against the Avalanche running away with the Presidents’ Trophy lies in their nine-game PDO, an abnormally high 1067 based largely on that .961 save percentage.

PDO tabulates a team’s save percentage and shooting percentage, and teams that are far above 1000 should regress while teams that are well below 1000 should improve.

So, how high is a PDO of 1067? In the past three 82-game seasons, the league leaders had an average PDO of about 1020.

Over the past three seasons, the Avalanche’s PDO was consistently in the 980s as they failed to reach the postseason. The makeup of this year’s team isn’t much different than the one that finished 29th in the standings last year, so it’s a logical leap to think this team is playing way over its head.

Nathan MacKinnon is good, but he’s not that good.

PDO aside, an outstanding nine-game stretch is quite common for even the worst of teams during an 82-game season.

The 2011-12 Montreal Canadiens and Edmonton Oilers had 7-2-0 runs early that season and finished 28th and 29th in the league, respectively. That season’s Minnesota Wild team became PDO poster boys after jumping to a 20-7-3 start before crashing back to earth with a 15-29-8 record over their final 52 games.

The 2010-11 Avalanche had a 6-1-2 stretch in December but stumbled to 69 points and a 29th-place finish.

Colorado Avalanche Game-by-Game Shot Totals
OpponentShots ForShots allowedResult
vs. ANA2936W, 6-1
vs. NSH3627W, 3-1
at TOR3328W, 2-1
at BOS3039W, 2-0
at WSH2841W, 5-1
vs. DAL2641W, 3-2
vs. DET4028L, 4-2
at BUF2630W, 4-2
at PIT1434W, 1-0
NHL statistics

PDO isn’t a foolproof way to predict a team’s performance, but it’s a strong indicator of which teams are playing over their heads over small sample sizes, and the Avalanche fit the profile really well right now.

If the Avalanche’s bloated PDO doesn’t convince you that the team will take several steps backward as the season moves forward, perhaps its subpar Corsi and Fenwick numbers will make the case.

The Avalanche are below average in both Corsi and Fenwick, which is just an elegant way of saying they are being outshot by the opposition on a consistent basis.

In the Avalanche's 1-0 win against the Pittsburgh Penguins on Monday, they were thoroughly dominated. The only thing keeping them atop the standings is the play of Varlamov and Giguere, who are a combined 104 save percentage points above their career averages.

It's like a deal with the devil that's not withstanding. As long as the Avalanche continue to be porous defensively, it’s only a matter of time before things take a turn for the worse in Denver.

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Notre Dame Football

Notre Dame Football: Is Amir Carlisle Poised to Break out in 2014?

Notre Dame running back Amir Carlisle runs against Purdue during the second half of an NCAA college football game in West Lafayette, Ind., Saturday, Sept. 14, 2013. (AP Photo/Michael Conroy)
Michael Conroy/Associated Press
Mike MonacoContributor IMarch 28, 2014

SOUTH BEND, Ind. — Amir Carlisle has flashed his potential before.

Whether as a freshman running back at USC in 2011 or in either of his two seasons at Notre Dame, Carlisle has shown glimpses of the ability that made him a 4-star prospect coming out of high school.

He has battled injuries during his career, and now he has a clean bill of health halfway through spring ball. The running back also saw time as a receiver, and now he has officially made the switch and is working exclusively with the receivers out of the slot.

“I’m feeling increasingly more comfortable each and every day with learning how to release off press-man, second-level releases,” Carlisle said of the position switch. “So each day I’m having a greater sense of comfort, but it’s definitely been a learning experience and it’s been a fun experience.”

In practices open to the media, Carlisle has made fine receptions out of the slot and has also motioned into the backfield to take handoffs. Carlisle possesses such versatility, as the Santa Clara, Calif., native carried 47 times for 204 yards and tallied seven receptions for 30 yards in 2013.

“Hopefully it’s just any way to get the ball in my hands in space,” Carlisle said. “I feel like I operate best when I have space to operate, whether that’s maybe taking a stretch play or getting the ball on an under route, or a dig, or whatever. I’m trying to be as versatile as I can be with working, doing the extra work and really learning the little details of the game.”

Carlisle transferred to Notre Dame following his lone season with the Trojans, and he was then granted a waiver, meaning he didn’t need to sit out the 2012 season. But Carlisle did end up sitting out, as he was redshirted because of a broken ankle. Carlisle made noise last year in spring practice, only for it to be cut short after he broke his collarbone.

Still, the 5’10”, 190-pounder was ready when the 2013 season rolled around, and Carlisle had at least nine touches in each of the first three games, including the season opener against Temple, when Carlisle scampered 45 yards around the left side on the first play from scrimmage.

Carlisle played a regular role in Notre Dame’s offense through the first three games, but his production dropped mightily after a fourth-quarter fumble in Week 3 against Purdue (see chart below).

Amir Carlisle: Game-by-Game in 2013
Michigan State39
Arizona State28
Air Force33

 “For me, I’m a team guy. All I care about is winning and my team,” Carlisle said of his lack of involvement. “So I kept high spirits throughout that, stayed optimistic, kept working hard in practice. For me, I was the same guy throughout, worked hard each and every day.”

Irish head coach Brian Kelly said last week Carlisle is performing well in the slot and has seen much of the work at inside receiver, along with junior C.J. Prosise. Kelly said he didn’t know if Carlisle lost confidence as a pass-catcher last season and admitted Carlisle was never given a great opportunity in the passing game.

“I don’t know that I would say that he lost his confidence in that sense,” Kelly said. “His role diminished as the season went on as [sophomore running back Tarean] Folston kind of picked his game up, and he may have felt like he was less involved in the game plan, but he looks pretty confident right now.”

Some of that confidence stems from experience, Carlisle said. Though the production wavered throughout the season, Carlisle called it a “blessing” to have a completely healthy season.

“It’s a great feeling [to be healthy],” Carlisle said. “Coming through last season, getting through the season healthy, being able to get through our entire winter workouts healthy, coming into the spring healthy, that experience is priceless.

“There’s so much you can learn by watching. Mental reps are very valuable, but then there’s a whole other deal with you getting on the field and actually working through the things that you’re learning in the meeting room.”

With his quickness and open-field ability, Carlisle projects as a solid offensive weapon for the Irish, however he gets the ball. Carlisle also mentioned he’s competing for the kick-return and punt-return jobs.

The flashes of potential have always been there, dating back to a 90-yard rushing performance as a freshman against Colorado. Now, Carlisle is fully healthy and feeling increasingly comfortable in a new position.

*All quotes obtained firsthand unless otherwise noted.

Mike Monaco is a lead Notre Dame writer for Bleacher Report. Follow@MikeMonaco_ on Twitter.

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A Brett Favre Report Straight from Hattiesburg, Mississippi

Bleacher ReportCorrespondent IJune 22, 2009

If you weren't familiar with the National Football League and were driving through the town of Hattiesburg, Miss., you would have no idea that football immortality lived in the vicinity.

Well, I do know the future Hall of Fame quarterback Brett Favre lives there and I have had a wish fulfilled by currently being in Hattiesburg on part of a trip with my dad.

I must point out that my dad wasn't as big on this as I was, he was simply doing it because he wanted to make me happy. He thinks I'm a little crazy for wanting to stop in Hattiesburg, which I might be, but its a story I have been following everyday and to see the sights in person would be something very unique.

Thanks to Garmin, we were able to find Oak Grove High School, the school where Favre has been doing his training throughout the offseason, throwing passes to test his arm strength. The latest thought is that Favre will sign with the Vikings if his arm is okay, and many have reported that it is.

The field was empty at approximately 5:45 pm local time, with only drill equipment being on the hot turf. Like us, another car was checking out the scene but left as soon as there was not too much to be seen at the moment.

Now, it was put in place that we must see his home. However, there was one problem. Garmin does not list Brett Favre's house in it's system, not even under points of interest.

Well, this was my only interest and I wasn't going to be stopped.

Next destination, the Microtel down the road, our spot to stay for the night. My dad checked in, found out that internet was free (makes this article possible right now) and asked about Favre's location in the city.

"Everyone knows where Brett Favre lives," the front desk worker said and gave us the directions, which were pretty simple. Drive to the high school, but instead of turning off of the highway, drive another three miles.

We took the directions, thinking many gated areas might be his place, but not being confident in our guesses. Finally, we saw a nice fence and a big gate that we knew had to be it the second we saw it. Sure enough, a big "F" was on the gate. Somebody driving along would not be able to see the house because it is tucked away behind trees.

Last night, I did some research and came to the conclusion that most of Favre's high school workouts took place in the morning.

My alarm rang today at 7:00 am this morning (Monday) and we made our way over to Oak Grove High School for the second consecutive day.

My excitement grew when I saw players on the field doing some sprints. As we made our way to the gate, a man who worked at the school told us that Favre usually worked out on Wednesdays.

Well, there went that idea.

Of course, I had to ask him about Brett's work and how he was looking on the field.

"He says it hurts, but he knocks those kids right into the ground on those 20 yard passes. It doesn't look like he's hurt," the man said.

This would make sense after the Oak Grove Head Coach make comments similar to this statement this weekend on Sirius NFL Radio.

Although I did not get to see the legendary quarterback, I did get to see much of the setting that had only been a television sight for me the past two offseasons as I have followed Favre's situation.

It was well worth the trip there and although I did not see Favre in person, my guess is I will see him in a different setting later on.

That being in a purple jersey on the Metrodome turf for the 2009 NFL season.

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Archive for August, 2012

Episode 68 – Freaking 5.0!

Posted: 28th August 2012 by Kurn in Podcast

Yet another episode of Blessing of Frost has arrived and this time, Kurn and Majik talk about the impending arrival of Patch 5.0.4, which hits today, Tuesday, August 28th, 2012.

First of all, please enter our contest for a Lil’ XT pet (possibly US realms only?)! Just send us your comments or questions to […]


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Keywords: advertising, clean, colorful, corporate, creative, digital, earth, elegant, entertainment, ideal, internet, it, layer, media, modern, non-profit, people, professional, programmer, round, simple, sphere, technical, technology, unique, world.


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Angel's Asylum

Follow This Show

Stay in the know about new episodes and updates.
Anything and everything! We may have a topic like anything scarrryyy or we might just talk about what's going on so join me ! Chat room opens at Friday 11:30 pm show starts at Midnight !

On-Demand Episodes

Christopher Inlow joins me from Epicon from Albany GA !

I'm back and with a special guest !!

Space Pirate joins me !

Danny Donovan joins me as we talk about the Portsmouth Ghost Walk and a plethera of subjects so come on it !

it's my Birthday but this show isn't about that. Call in if you want.

From Haunted Journeys and Haunted Travels USA Geister Reese joins me !!

Scarred, Hellweek ... That's Jonah Kandie !! He joins us from L.A. don't miss it !!

Mike Maxim, Mr. Manicle from The Insanity Show, joins me as we talk about some issues in the Horror community and convention news !

Friends come to the resue !!


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FFToolbox Radio: Fantasy Football Preview - NFC South

  • Broadcast in Sports

Follow This Show

If you liked this show, you should follow FFToolbox.

It's beginning to look a lot like football...everywhere you go...

OK, I take some liberties from the old holiday tune, but it is definitely feeling like the NFL-gears are starting to turn faster and faster! Over the months of June and July FFToolbox Radio is going to take you through every NFL Division, breaking down the teams, the positions, the sleepers and the busts so be sure to head on over to iTunes (or Stitcher or BlogTalkRadio or wherever!) and SUBSCRIBE so that you don't miss a moment of the conversation.

As always, you can catch the show live on Tuesdays at 7:30PM ET at the blogtalkradio.com website.

June 10, 2014 - Birds and Cats, Swashbucklers and the Fleur-de-Lis, tonight we've got the NFC South Preview. Listen to host Micah James (@FFMagicMan) and special guests, Rick Fleeger and Rick Briggs from AsylumFootball.com (@asylumfootball) cover this high-flying quartet of team for all your 2014 fantasy questions.


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Faith Healing - Cultish fraud?

  • Broadcast in Religion
God Discussion

God Discussion

Follow This Show

If you liked this show, you should follow God Discussion.

For centuries, people have placed their trust — and physical and spiritual well-being — in the hands of priests, ministers, rabbis, gurus, revival preachers, and New Age spiritualists. In many cases, this trust was misplaced, resulting in tragic results.

“Faith healing” is the practice of curing diseases by nothing more than faith. Medicine, doctors, therapies and other scientifically evaluated and based medical practices play no role in faith healing. A “faith healer” is an individual who allegedly possesses a great gift of healing from God Almighty. One of the most often parroted lines in the healer’s spiel is, “I believe, in Jesus Name, be healed!”

Whether the healer or the person being healed has the required level faith differs according to the result.

Is faith healing something that can produce belief-based miracles?  An entertaining cultural activity?  Or is it a cult-like activity that is capable of harm? Call into the show to talk about your experiences and to share your opinion.

Rob Robinson's World Cult Watch airs every Sunday night on the God Discussion network.  Please visit GodDiscussion.net for our upcoming show schedules, and learn more about cults at WorldCultWatch.org.  This and other shows are brought to you by GodDiscussion.com, featuring daily religious and church/state news and commentary.


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West Virginia Classics: $1-Million Dream

Sam Huff is better known for his career as a pro football player, but he's also a Thoroughbred owner with a real passion for the game. This year, he realized a dream when total purses for the West Virginia Breeders Classics series hit $1 million.

On Saturday night at Charles Town Races, eight Classics races will go for $850,000, including $250,000 for the Classic itself. Divisional prep races held at the West Virginia track earlier were worth $150,000.

The first West Virginia Breeders Classics was held in 1987. Huff, who founded the series, said it was a bit tough getting the money to initiate the program for state-breds, which followed on the heels of the Maryland Million. With a funding mechanism in place, and a revitalized Charles Town Races as the host, the series is well-established.

"Breeders Classics One was one of the greatest days in my life," Huff said Saturday morning during his annual "Breakfast of Champions" to benefit the Racetrack Chaplaincy Program. "I don't remember all the horses that won, but I do remember Onion Juice winning the big race."

Onion Juice, a local legend, now has a Classics event for 3-year-olds an up at seven furlongs named after him.

The "Breakfast of Champions," hosted by ESPN commentator Chris Lincoln and held in the clubhouse at Charles Town Races, gives attendees a chance to meet former Washington Redskins and other National Football League players. Almost $1,000 was raised when baskets were passed around for those who wished to donate to the chaplaincy program.

On Friday night, the local Horsemen's Benevolent and Protective Association held its horsemen's night, which featured three $50,000 stakes and a minimum purse of no less than $20,000. Total purses for the weekend topped $1 million, a record for Charles Town Races.

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