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Embark’s Test for Genetic Coefficient of Inbreeding (COI) Brings A New Tool to Breeders

Embark’s Test for Genetic Coefficient of Inbreeding (COI)

Embark’s Test for Genetic Coefficient of Inbreeding (COI): For millennia, dog breeders have intentionally bred relatives as a way to fix traits in a lineage. A century ago, Sewall Wright devised the coefficient of inbreeding (COI) as a way to measure inbreeding, a statistic still popular today. Like humans, dogs tend to be 99.8-99.9% genetically similar to other members of their species. Even other species can exhibit similarities—dogs and humans are 64% similar at the base pair level. But genetic variation is the spice of life, and the 0.1-0.2% of the genome that differs encodes a myriad of variation. Some of these variations we have intentionally perpetuated, like body shape, coat color, and behavior. Unfortunately, other less desirable variants confer potentially harmful effects on health, longevity, and reproductive success.

Harmful mutations come in three main varieties; recessive, dominant, and additive. The harmful dominant and additive mutations are quickly weeded out in large, outbred populations. This occurs because the individual carrying these mutations has a reduced fitness. Recessive mutations, on the other hand, are different. A harmful recessive mutation might “break” a gene. This has little or no consequence if an individual has a working copy of the gene from his or her other parent. However, this can have disastrous consequences when an individual inherits two broken copies. Outbred individuals almost never inherit two broken copies. Therefore, natural selection or breeders cannot effectively select against them unless there is a genetic test for the mutation. For example, if a mutation is at 1% frequency in an outbred population, any given dog has a 0.01% chance of inheriting two copies of the mutation—clearly a very small chance. As such, every dog population—or in the context of purebred dogs, every dog breed—contains an abundance of rare recessive mutations that were either present in a founder individual or arose spontaneously in the dog population sometime afterwards. These rare mutations are hardly ever problematic for outbred individuals because they almost always inherit at least one working copy; however, they can cause real problems for inbred individuals—animals that arise from the mating of closely related parents.

Let’s consider what happens with dogs in a mother-son mating. A mother passes along 50% of her genome to each pup, so each rare (<1% frequency) recessive mutation carried by the mother has a 50% chance of being transmitted to a son. Offspring from a mother-son mating would, therefore, have a 25% chance of inheriting two bad copies of the mutations that have been passed down to the son. This is a greater than 100-fold risk compared to an outbred dog! Inbreeding in dogs has real consequences. Research in the Embark Co-Founder Adam Boyko Lab has shown that a 10% increase in inbreeding can lead to a 6% reduction in adult size (poor growth) and a six- to ten-month reduction in lifespan. Reduced litter size and fertility are also likely. These risks occur from both classical inbreeding and from drift in small populations where every individual is a not-so-distant relative. Assessing these risks depends on accurately quantifying the likelihood that mutations will be identical-by-descent, or inherited from the same ancestor.

Embark’s Test for Genetic Coefficient of Inbreeding (COI)
Embark’s Test for Genetic Coefficient of Inbreeding (COI)

Calculating coefficient of inbreeding (COI)

There are three ways to quantify the coefficient of inbreeding (COI): (1) Using a pedigree, (2) Trying a small set of polymorphic markers, or (3) Testing a genome-wide marker panel. How do you easily find out?

Pedigree-Based coefficients of inbreeding are based on the relatedness of individuals in a pedigree. 25% is the value from a mother-son or full-sibling mating; 12.5% being the value from a grandparent-grandchild or half-sibling mating; and 6.25% being the value from a first cousin mating. These values accumulate. Logically, all individuals have COIs between 0% (completely outbred) and 100% (completely inbred). So, three generations of full-sibling matings would lead to a COI of 50%. Ideally, the pedigree is complete all the way back to the founding of the breed. However, in reality, most pedigrees only go back, maybe, 5 to 10 generations. Most COI calculators assume that the original ancestors in the pedigree are unrelated. Therefore, a COI calculated from a 5-generation pedigree could be much lower than that calculated from a 10-generation pedigree. This is likely much lower than the true COI if the complete pedigree back to the breed founders was known. For this reason, there’s no one answer for what a “good” COI is; it all depends on how complete the pedigree is. Furthermore, because of the principle of segregation, two individuals with identical expected COIs from a pedigree may have very different levels of inbreeding. This depends on which individuals inherit which chromosomal segments.

Marker-Based Inbreeding uses dozens or hundreds of widely spaced markers to estimate inbreeding. Each marker can be heterozygous or homozygous (identical by state). The overall locus heterozygosity (HL) of the panel is generally correlated with inbreeding. However, the absolute values of HL depend on the markers that are chosen. Because a rare marker being homozygous is stronger evidence of inbreeding (identity by descent) than a common marker being homozygous, different weightings may be used to calculate statistics like internal relatedness (IR). This varies from -1 to 1. Nevertheless, most of the genome is not linked to any marker. Therefore, estimators do not detect most inbreeding tracts. As a result, it makes marker-based estimators poorly suited for differentiating between individuals with similar COIs (less than 5-10% different).

The genome-wide genetic coefficient of inbreeding is the gold standard for measuring inbreeding. It requires at least tens of thousands of markers spread across the genome. The Embark Dog DNA kit includes Genomic-wide COI results. With this resolution, the actual inbreeding tracts can be directly observed as tracks of homozygous markers. Above a certain size, these runs almost always represent identity-by-descent, and thus we can easily calculate the coefficient of inbreeding (the proportion of the genome that is identical by descent). At Embark, we use about 1 million basepairs, known as 1 centimorgan, as the minimum size of each track. This is because we are interested in inbreeding all the way back to a breed’s founding; remember, for most domestic dog breeds, this is usually 50-100 generations ago.

Calculating the genetic coefficient of inbreeding directly using genome-wide data has several advantages. It doesn’t require a pedigree. Also, it doesn’t depend on marker frequencies or require complicated statistics to correct for rare/common markers. And finally, it is directly comparable across studies because it doesn’t depend on the specifics of the markers used or the populations being studied.

Inbreeding tracts are apparent using genome-wide data. Pedigree-based and marker-based estimators often miss these tracts. Comparing an individual to the genetic coefficient of inbreeding distribution for the breed lets you know whether a dog is more or less inbred than expected for its breed. You can visualize the inbreeding tracts to see where in the genome they are found. Accurate determination of inbreeding tracts is crucial for identifying recessive disease mutations through homozygosity mapping. It is also crucial for more precisely understanding the risks of inbreeding within and across breeds. Although some level of inbreeding cannot be avoided for most purebred dog breeds, and inbreeding risk shouldn’t be the only consideration when selecting mates, reducing the inbreeding load in a population is a valuable goal.

  • Our mission is to end preventable disease in dogs. By working together, we aim to leverage Embark’s unique capabilities to accelerate the pace of discovery and make our findings more quickly accessible to owners, breeders, and veterinarians. Embark is the only DNA test provider to leverage a research-grade platform using over 200,000 genetic markers. This platform enables cutting-edge research and genetic mapping studies to occur immediately, while also archiving genetic data for future initiatives.

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Autumn Daze

Autumn might be my favourite season. Mind you, I say that about every season, except Spring. Spring is just sort of there, it’s usually a bit damp, chilly and disappointing, an end to Winter and a preclude to Summer rather than a season in its own right.

I love so many aspects of Autumn; it’s the season for the swotty Hermione’s like me; all preppy leather shoes, woollen tights and knee length socks, colourful leaves and beautiful sunsets, perfect walking weather, there’s bonfires and fireworks and a sort of sense of communal spirit, you feel justified staying in and just curling up to read in a cosy nook or marathoning a show on Netflix, you can actually buy real pumpkins to make all the plethora of delicious pumpkin recipes that you have to sadly use butternut squash as a substitute for if you want to bake outside of the months of September and October…

Autumn isn’t the exciting bloom of change, it’s the slow comforting ageing of the year. It’s the time for reinvention and progress.

This year, I’m dreading it.

Every year of my life so far, September has always brought a new beginning with a solid routine; a new academic year. Reassuring, comforting routine, even when it was nerve wracking, there was a sense of familiarity to it. This September instead sees me in a new house, but with no new course or academic institution, no job, no money, no means of transport and far away from some of my closest friends. I’m living back with my family after three years of independence, a strange regression in routine. It’s a new house from the one I’ve called home for the past 19 years, and currently I’m sleeping on the floor until the carpet is fitted and my bed is delivered. It’s exciting, but in a slightly detached way, as this is my parents’ new home, not mine. We don’t have a working oven in this house yet, which puts pay to the way I filled a lot of my last empty year in Worcester. The news is relentlessly depressing, with seemingly little hope for my generation, reminding me this might be the last ‘bought’ house I ever move into.

Hmm. I didn’t intend this blog to be a list of my woes. As people keep saying ‘things will get better’, ‘it’s just a moment in time’, ‘it is what it is’.

Those are all pretty empty words, so instead I shall share some things I’m going to try and fill my Autumn with. You can suggest some more to me, or join in.

Autumnal Playlist:

Ironic – Alanis Morissette

Hips Don’t Lie – Shakira

Defying Gravity – Lea Salonga

Revelry – Kings of Leon

Do You Want The Truth or Something Beautiful – Paloma Faith

One More Time With Feeling – Regina Spektor

Paradise By The Dashboard Light – Meatloaf

Most of these have precisely no discernible link to autumn, but they evoke that warm, slightly melancholic, reflective feeling I associate with autumn anyhow…art is all about interpretation, okay!

Autumn TV and Film:

It’s a wasteland out there folks.

The BBC is dredging up it’s most outdated, offensive sitcoms for the enjoyment of people who voted for Brexit.

I suggest looking up The Chronicles of Nadiya here if you love food and travel shows (who doesn’t?!), and Jenna Coleman is resplendent in Victoria if period dramas are your cup of earl grey.

Otherwise, trawl Netflix/Amazon Prime etc for your latest boxset binge. I’m personally looking forward to the French-British collaboration on Amazon Prime, The Collection. It is about the glamour and ugliness behind the scenes of a Parisian fashion house just after the Second World War. It has a stellar cast; Richard Coyle, Michelle Gomez, Frances de la Tour and Tom Riley, amongst others, and I’m hoping for a sort of Mad Men meets Dancing on the Edge vibe.

And of course, you should all already be watching Steven Universe.

Autumn Reads:

I recently bought a beautiful deck of animal spirit cards from The Wild Unknown; I’ve always had a great interest and attraction towards what I’m going to collectively term witchiness (judge all you like, Hermione never cared). I’m going to use them as a tool for personal insight and as creative inspiration because they’re gorgeous. But as someone reminded me recently, the way they are interpreted is very similar to the alethiometer in His Dark Materials. This has made me desperate to re-read this book series.

His Dark Materials (Northern Lights, The Subtle Knife, The Amber Spyglass) by Phillip Pullman

The world created by Pullman is so immersive and beautifully built and expressed. The concept of Dust, daemons, the witches and armoured bears…there are so many diverse ideas and characters overflowing from this series. It should have been a beloved classic alongside Harry Potter, but they completely screwed up the feature film which seemed to curb the number of people my age who have read it. It also epitomises a lot of autumn for me; the ideas of a coming of age and both a nostalgia for that which is lost and excitement for what it is to come.

If you enjoy human-rooted fantasy, flawed protagonists and the idea of your soul being a visible animal who lives beside you, I recommend you give this book series a go before the BBC TV adaptation hits the screen.

Pumpkin Recipes:

Pumpkin Pie

Chimichurri Pumpkin Bowl

Classic Pumpkin Soup

Pumpkin Spiced Syrup

Pumpkin Cocktails OH YES INDEED

Basically All Of These

I just love pumpkin DON’T JUDGE ME.  I’m sure I can do some of these without an oven.

I’m also going to be having a peruse of these online courses, as well as hopefully kick-starting my writing again. In case any of these also interest you, here are some links:

Healing from Toxic Whiteness

Mindfulness for Wellbeing

Italian for Beginners

How to Read The Mind of a Fictional Character

I know all that was an odd mish-mash of content after a long while of not posting, but I hope by sharing all that I’ll actually keep to some of my autumn intentions…including keeping on top of this blog regularly (anyone else got deja vu…).

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Alex's Place - Paediatric Physiotherapy Service

Alex's Place is a paediatric practice in Stafford that provides neuro developmental therapies like: NDT – Bobath, Vojta, SI, CST, PNF, Kinesio Taping etc. Alex’s Place was established to provide a variety of therapies on the highest level. This paediatric practice is fully equipped, certified and well prepared to provide neuro developmental therapy to children all age and with different needs like:

  • Global developmental delay
  • Muscle tension disorders
  • Sensory processing disorders
  • Orthopaedic and neurological problems and diseases
  • Genetic and metabolic diseases
  • Faulty posture

Beside neuro developmental therapy Alex's Place offers also psychomotor development assessment and child care consultation of infants and children.

Who to contact

Contact Name
Aleksandra Szlapa
Contact Position
Paediatric Physiotherapist

Where to go

Alex's Place
5 Prince Avenue
ST18 9ET
Children's Centre Areas

Time / Date Details

When is it on
Open Monday to Saturday from 10am until 6pm

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Unilever Gives a Preview of Worsening Inflation Pinch | Sidnaz Blog

Inflation is becoming as much a headache for CEOs of household-staples companies like

UL -0.19%

as for shoppers. Their ability to pass on price increases hinges on where and what they sell.

The U.K.-based maker of Hellman’s mayonnaise and Ben & Jerry’s ice-cream said Thursday that sales increased at a healthy 5% clip in the three months through June, compared with the same period of 2020. Some products that saw demand slump during lockdowns, such as deodorant, have returned to growth now that social restrictions are being lifted in certain countries.

However, Unilever’s shares fell 5% in early London trading because of new profit guidance. Operating margins are expected to be flat in 2021, down from the slight increase that Chief Executive Officer

Alan Jope

was targeting just three months ago.

Inflation is the clear culprit. For Unilever and its main European peer Nestlé, costs of goods sold amount to around half of revenue. Bernstein recently estimated that over the next 12 months these two companies face roughly 14% increases in bills for everything from plastic packaging to food commodities. On a call with analysts, Unilever’s finance director said that costs spiked again in the latest quarter. Soybean oil prices, an important ingredient for the company’s salad dressing, jumped 20% compared with the first quarter.

Predicting who has the best ability to pass on these higher prices to consumers isn’t easy, but investors can look for clues in market-share data, as well as companies’ mix of products and countries.

Unilever, the maker of Dove soap, said costs spiked again in the latest quarter.

Even though consumers have less disposable income on average, it is easier to increase prices in emerging markets than in mature economies. This is because supermarkets in developing countries often have less bargaining power than in Europe and the U.S., where grocers are more consolidated. Unilever’s high exposure to emerging markets, which contribute roughly 60% of group sales, is positive. However, it can only push so far before pinched shoppers trade down to cheaper brands. This is already happening in Indonesia.

The company and its main rivals will have to fight harder in Europe, where price negotiations between consumer-staples companies and supermarkets are notoriously fraught. In certain markets like France, the prices of some goods are in deflation.

This week’s controversy over Ben & Jerry’s decision to stop selling ice cream in Israeli settlements may not help the task. The move taken by the brand’s independent board could cause problems for Unilever in the U.S., where it has spent years trying to improve its competitive position. Any slip in consumer demand will make it harder to increase prices.

Lastly, the split of luxury and mass-market brands in consumer companies’ portfolios will determine how much they can shield margins. It is easier to raise prices for premium products, such as Unilever’s posh cleaning brand The Laundress, than for mundane brands where shopper loyalty is weaker.

Consumer bosses face a delicate balancing act to get through this year with both their margins and market share still intact.

The U.S. inflation rate reached a 13-year high recently, triggering a debate about whether the country is entering an inflationary period similar to the 1970s. WSJ’s Jon Hilsenrath looks at what consumers can expect next.

Write to Carol Ryan at [email protected]

Copyright ©2021 Dow Jones & Company, Inc. All Rights Reserved. 87990cbe856818d5eddac44c7b1cdeb8

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April 27, 2020
How to choose15463 Up Fresh Russian Women
April 28, 2020

Get a U S i9000. Visa

In some African cultures, such as the Fischzug people in Equatorial Guinea, and a few areas in Uganda, the well worth is taken into account the “buy worth” of a partner. One stage of critics says, the husband consequently might work out economic control over her.

Gender inequality in China has increased competitors for ever larger bride costs. Financial misery is an unwanted and dismissed justification for not paying the star of the wedding worth. If the grooms’ aspect cannot consent or pay off, they or simply the soon-to-be husband himself should nonetheless pay a bride price as a result borrowing by relatives is a popular if not required choice to “save face”.

While there could possibly be still zero formal requirement of a minimal income, the coordinator must give evidence of income (such since the T4 tax slip right from an employer) with their IMM 5481 Support Evaluation. One of many adjustments was conjugal partner sponsorship, to choose from for any two folks (together with similar-sex couples) that have had domestique relations together for at least a person 12 months. A large number of worldwide brides come from creating nations in Asia.

In some societies, marriage is delayed right up until all money are made. If the wedding occurs before all payments are made, the place is remaining uncertain.

Rose Wedding brides

Amounts essentially observe the regular reddish envelope business meetings although the sum is much more important. You are able to affect live in Thailand long run when you are married into a Thai or if you have a Thai teenager or children.

May 18 is a especially auspicious day on which to pay the bride benefit and get married to as its Chinese wording is definitely phoenetically much like “I will get rich”. Bride costs happen to be rising speedily in Chinese suppliers largely while not documentation nonetheless a definite mental and cultural understanding of the spot bride costs are at present.

The worth alone, impartial in the value, is definitely symbolic, even though the customized in addition has been identified as “the certificate of happily owning a home within the Photography equipment establishment of marriage”. In certain African cultures, the price of a bride is related together with her status and esteem in the community (Ankole, Tooro), an aspect which was by foreighners criticized since demeaning to girls.

The legality of mail-order relationship

During the Cost of Interrogation into Could Status in Marriage and Divorce (Kalema, 1965), exclusively one of many six commissioners was a girl, as well as the sampling of opinions on the problem was closely biased in favour of males. This is reflected in one of many primary suggestions from the fee, specifically the retention of bride wealth, in spite of robust problems by girls in regards to the practice (Tamale, 93, as offered in Oloka and Tamale, 1995, p. 725).

International marital life agency

Star of the wedding prices vary from CN¥1, 500, 000 in famously money-centric Shanghai to as little as CN¥10, 000. As well typically essential together with woman value are occasionally a home (apartment would work, however leases will be not) and a vehicle underneath each or perhaps only bride’s name, not of in whose dollar beliefs are measured against the star of the wedding value themselves. In some parts, the bride’s family could demand other styles of presents, none counted against the star of the event worth alone.

Inability to pay is definitely cause for protecting against a wedding which usually either facet can similarly suggest. Publicly, households report bride well worth as sustenence in case the man abandons or perhaps divorces the wife and that the bride well worth creates goodwill between family members. The groom’s facet seriously ought to pay greater than what the bride’s facet seems to have demanded to “save face”.

The majority of Cookware mail-order brides to be come from the Philippines, Thailand, Ceylon (veraltet), India, Taiwan, and China. In sub-Saharan The african continent, the visits between households to concerned the bride-to-be value will be conventional customs that are thought to be by many Africans to be central to Photography equipment marriage and society. The negotiations themselves have been described as the crucial element of the pursue as they supply families of the bride and groom the chance to fulfill and forge important you will have.

The marriage visa for Thailand is given at a Thai Charge in your house country and it’s generally issued to be a single obtain visa and valid meant for 90 days when you enter Asia. In June 2013, The Philippine charge in Seoul reported so it had got many problems from Filipinas who have hitched Korean males by way of mail-order, frequently evolving into “victims of grave abuses”. The ladies have already been marketed in online and offline “catalogs” to South Korean males. In many cases however , patients had been provided false information about the background with their future partner and relatives, and endured abuse from South Korean males, which will led to “abandonment of the marriage residence, separating and divorce”, Villasanta mail order bride stated.

The countries the women come from will be confronted with lack of employment, malnutrition and inflation. Nevertheless , financial components usually are not normally the one driving issue for ladies in Asia to enter the mail-order transact. Filipina young women typically went into the mail-order industry in the hope of marrying abroad, and then selling their household for migration. In some instances young women have been recruited based on the physical appearance, with a great emphasis positioned on youth and virginity. That is discovered among boutique businesses, most of which cater to wealthy men by different Hard anodized cookware nations.

Discover a lawyer

The bride worth custom can easily have unsafe results once young men haven’t received the method to marry. In strife-torn Southerly Sudan, a large number of young men take cattle due to this, typically jeopardizing their lives. Depending on the wealth of the bridegroom he wonderful household can type in right into a not for written deal with the bride’s household much like the Jewish Ketubah, by which he promises to pay what this individual owes quite specified time period.

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Computer TipsHow To

Download DriverPack Solution 2020 Full Version

DriverPack Solution 2020 Online (drp online) is a program that automates the process of installing hardware drivers. No longer do you have to deal with any more problems regarding searching for the right drivers and then installing them as this software will allow you to install all the required drivers on any Windows-based computer (from XP onwards) with just a few clicks of the mouse. It also supports 64 bit systems. The program is designed to be used by anyone from home users to system administrators, offering you an easy, quick, and efficient way of installing the correct drivers for the devices attached to your computer and then keeping them up to date. This software also has the widest range of support, covering all sorts of devices including USB devices, PCI, ACPI, PNP, and much more. When you start using the software, the driver installation process will be fully automated, and since it already contains a comprehensive database of drivers, you don’t even need to be connected to the Internet at the time. Drp online contains 1,131,989 manually selected and tested drivers!DriverPack Solution 2020

DriverPack solution’s latest release dynamically moves along persuasively with all types of PCs and laptops regardless of their model; furthermore, it adequately provides the appropriate and approved drivers.

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The initial startup window is entirely uncluttered with automatic installation option displaying the number of required installations, all the system software and drivers are listed in the respective windows with checkboxes to make selections with the update options.

It also bestows the information about the system and the hardware onboard like, motherboard, multimedia, input, output, printers, etc. DriverPack Solution 2020 administers the brisk course of action to configure the computer, saves from the hassle of purchasing DVD/CDs for drivers and retaining them, with this tool you will definitely never weather the storm. The software will recover the lost drivers for as long as it stays on board, it is a superlative available application to configure the operating system expeditiously.

READ ALSO: How to Keep Drivers Updated with DriverPack Solution Online 2020 Full Version

DriverPack Solution 2020 is provided for free landing-feature and it officially cooperates with antivirus software manufacturers and protects your computer, in a nutshell, this program has the largest driver database in the world and can be used to configure any computer.

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Nobody will install any software on his computer without knowing its benefits or because of some urgent requirement. So let’s have a look at few of the benefits which you can have by using this software.

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How to Keep Drivers Updated with DriverPack Solution 2020 Full Version

In order to have proper benefits from this software, it is important to keep your software updated. It is not a very difficult task to update driverpack Solution online in order to keep your drivers updated. You just need to follow the following simple steps to update your required drivers.

  • Go to the down of this post and download Driverpack Solution Online Installer 2020 Version For Free
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DriverPack Solution 2020 Latest Version For PC

The driver pack solution software is awesome. Many people call it DRP for short names. DRP is a great solution to keep all driver updates on PC. This software is even the solution to all the drivers that are still missing on your PC. Because this software updates all kinds of old drivers on your PC installs missing drivers, repairs useless drivers, removes unnecessary drivers. Its biggest advantage is that it has added to the latest version of all the data of Driver Pack 2019. So all new and old laptops or desktop drivers can be solved quickly
Sound card driver, graphics card driver, wireless driver, webcam driver, printer driver, scanner driver, TV card driver, LAN card driver, and many more.

To download it you have to use torrent. The advantage of torrent is that you can control the download as you like. You will get speed like IDM to download with torrent file. You can download the file with a lot of good quality software like uTorrent or BitTorrent. Brother, downloading this software should not be a problem.
Below is a shortlist of drivers that can be installed or updated with this software:

  • LAN Drivers
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From Simple English Wikipedia, the free encyclopedia
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Perfume River

Huế is a city and a district in Central Vietnam. About 200,000 people live in the city of Huế. From 1802 to 1945 Huế was the capital city of Vietnam under the Nguyen Dynasty. Today people can visit the Imperial City, where the Nguyen emperors lived and ruled, and the tombs of the Nguyen emperors. Huế has an Medicinical University and is the seat of an archebishop.

The city is famous for food that is unique to the city, especially the dish Bún bò Huế.

It was also the place where the Battle of Huế was fought, which was one of the longest and deadliest battles in the Vietnam War.


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Cardiovascular illness

Other beneficial fruits embrace peaches, cantaloupe, and apricots. Vegetable sources embody candy potatoes, green and pink peppers, squash, broccoli, cauliflower, spinach and other leafy greens. Nuts, grains, fish and fish-liver oil, rooster, eggs, and beef will provide much more anti-oxidants in the food plan. Some of these meals are fat soluble, while others are water soluble, so you will need to eat a wide variety of them. Eating fruits, greens, legumes and oils as close to their natural state as possible makes it unlikely that you’ll eat a amount of vitamins that might be poisonous.

Dr. Anthony Fauci’s profession underneath six US presidents

In addition to consuming certain meals, it might be essential to eliminate others. Processed sugar has been shown to speed up the aging process. It is feasible to satisfy your sweet tooth by eating fruits, that are excessive in pure sugar.

Wellness for such things is not given significance till now, nonetheless the true depth of such ache has been publicized and broadly accepted by folks all around the world. There are many reasons like deficiency of sure necessary nutritional vitamins and minerals due to which one can develop pain that weakens your bone structure. Paying equal attention to healthy diet and having fun with your meals, you possibly can easily overcome this problem.

  • If a person’s body cannot management the spread of those cells, they will intervene with essential, life-sustaining methods and probably lead to dying.
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Parish Magazine: August 2018

August 2018, and it’s summer!

Jesus calls us to a radically new understanding of community and of status. Are we willing to accept that each and every one of us is already known and loved by God, regardless of our status in society, or our age, younger, older. Each and every one of us, loved and welcomed into the family of God. How can we extend that welcome and love to the children and families in our community, especially over this summer time?

Download this edition here.

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Six Points
News Article

Share the Season with Six Points!

Dec 16, 2020

Six Points Evaluation and Training Gunnison CO LogoShare the Season with Six Points!

December 2020
Download a PDF of this Letter (PDF, 66KB)

Dear Six Points Friends and Neighbors:

As we begin our annual Share the Season fundraising drive, reflecting back over years of generous contributions from this community, we invite you to show your support for Six Points by making a gift during the upcoming holiday season.

Six Points is so much more than a thriving thrift store. You may know that Six Points supports local adults with disabilities so that they may continue to live independently in our community. Did you also know that Six Points provides work for many individuals and supports others at their community jobs in Gunnison and Crested Butte?

You may be acquainted with many of our clients. During COVID-19, many of them have been staying safe at home to prevent the spread of the virus. They are doing well and we all wish to say, “Thank You!” to each and every individual who makes a donation or purchases items from our thrift store, because you are supporting our clients and helping them continue to live independently.

Despite the many challenges of this year, we would like to share a few successes from 2020. All our clients and staff have remained healthy. Six Points staff have demonstrated incredible dedication and creativity in finding ways to provide safe alternative services that meet our clients’ needs: gardening, outdoor recreation, picnics, and remote story time via Zoom to name just a few. The thrift store continues to provide essential revenue with the support of donations from the community.

Yet, even with all these successes, Six Points relies on contributions, grants, and gifts to operate. We are going into the winter season with a few more needs than usual this year:

  • Providing PPE for our service providers has been an additional expense to keep everyone safe.
  • Our van with the wheelchair lift has been struggling and will soon need to be replaced.
  • As Colorado minimum wage increases, the cost of living in the Gunnison valley grows, and Medicaid rates are cut, it becomes more and more difficult to pay our essential service providers adequately.

The holiday season is approaching once again, as we make our way in the new normal of 2020. Make your gifts unique and special this year.  As you consider what sort of gift to give to a friend or family member, consider the option to Share the Season and purchase a gift certificate or sponsor a contribution in their honor to Six Points. Six Points relies on donations to support the people we serve.  Every donation, small or large, makes a tremendous difference!

With deepest gratitude,

Nancy Lakiotes
Executive Director

Make an Online Donation Here

Six Points Evaluation and Training Gunnison CO

Six Points Provides


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Monthly Archives: February 2014

This is a guest post written by Jessica Sage and Kristina West, the founders of We the Humanities which went live today. A fantastic initiative, and in the week commencing 17th March I will be curating the account – yay! Follow @wethehumanities on twitter to join the discussion.

After seven weeks of preparation, curator-sourcing and generous support, We the Humanities launches today.  It’s the first rotation-curation Twitter account for the humanities, featuring a new guest editor every week who’ll be tweeting about their work or research in the humanities and their other areas of interest.  Set up by Jessica Sage and Kristina West, who are both part-time PhD researchers and sessional lecturers at the University of Reading, the hope is that it will offer a central platform for discussion and news of the humanities in all its forms.

From humble beginnings (a lightbulb moment whilst wearing pyjamas on a Sunday afternoon) the account now has more than 650 followers and 21 brave tweeters who’ve put themselves forward to curate for us.  Today’s launch sees the account being taken over by Louise Jackson, the Head of Learning Enhancement at Trinity Laban Conservatoire of Music and Dance.  Future guest editors include a senior lecturer in English and Cultural Studies at the University of Wolverhampton, an Assistant Curator in the Sculpture department of the Victoria and Albert Museum, and researchers from Norway, New Zealand, Australia and the USA.  We are also looking forward to adding participants from the business world, primary and secondary education and any other disciplines associated with or interested in the humanities.

The account’s set-up has been juggled with teaching and finishing a thesis (Jess) and teaching, PhD research and parenting (Krissie) and so it’s with relief as well as excitement that our first curation is underway.  It has been great fun getting to know some of our followers in the last few weeks – and we’ve been overwhelmed by people’s generosity in sharing the initiative, suggesting avenues of publicity and hosting us on their blogs – but this is a project that’s bigger than two individuals.  It’s this spirit of collaboration and the diversity of contributors that we hope will grow the account to reach more people, from those who’ve dedicated their working lives to the humanities to people with a mild curiosity in one particular area.

Although it’s a modest project, we hope that @wethehumanities will contribute to debates about the importance of the discipline and provide entertaining and informative perspectives on an ever-expanding variety of research, interests and hobbies.

You can follow @wethehumanities on Twitter here and you’ll find the blog here.  If you would like to curate for a week the details and sign-up form can be found here.  You can also get in touch with Jess and Krissie with any suggestions or comments that you may have by emailing them at wethehumanities AT gmail DOT com.

We the Humanities:

Jessica Sage:

Kristina West:

Louise Jackson:

For curators:

Passions, post-its, pictures, presentations, problems, personalities, paintings, projects, people. This post on the Idélab is brought to you by the letter P…

Idélab 6

P is for people. Photo: Forskningsrådet

In the last week of January I dipped below the radar somewhat; for I was part of Norway’s first ‘Idélab’. North American readers may recognise the term (idea lab); UK readers may know it as a ‘sandpit’. Whatever its name, it was an idea-generation event which was intended to produce innovative research projects seeking to pave the way for a zero-emissions society.

Twenty-seven delegates, six mentors, and representatives from Forskningsrådet (Norway’s national research council, who were behind the event) were led on a journey by Liz and Tim from the UK company Know Innovation (with help from Scotty and Paula). And what a journey it was.

Five days. Two days of defining and brainstorming the problem: what might a zero-emission society look like, and how might we achieve it? Two days of hashing out projects which could take us there. One day of presenting those projects to the panel and hearing their thoughts. Sounds simple?

Idélab 5

P is for posters

Idélab 3

P is for painting. A relaxing way to spend an evening getting creative juices flowing.

In some ways it was. Looking back, all we delegates had to do was relax and let ourselves go with the flow. That is not as easy as it sounds, for we had to place all of our trust in the leaders and mentors. Forskningsrådet, too, had to relax and let the week unfold at its pace. If that pace seemed gentle on the first day, by the Thursday the hours were flying by.

The week was a success. I say that unequivocally for one simple reason: we all cared. Leaders, mentors, delegates, organisers: we all worked together, warmly (sounds obvious? Then you’ve never lived in Scandi-land), respectfully, on equal terms.

Idélab 7

P is for personalities – questionnaire responses showed that more delegates were creative thinkers than any other category.

There was a cloud on the horizon, however. Following two days of encouraging all of us – perhaps particularly the so-called ‘hard’ scientists – to fully engage the social scientists and humanities in ideas for projects, then one day of thrashing out possible projects, the clanger was dropped: to be successful of funding in this round, projects had to advance research in two of the three areas funding the event – nanotechnology, biotechnology, ICT. This was, after all, what we had all signed up to some three months previously. It was not ‘news’ per se. But it had gone against the intense working we had been doing thus far. In short, the reminder, while not unnecessary, came too late in the game. Hopes for 50/50 social/hard science collaborations were dashed. Projects had to be abandoned, as those who (for whatever reason) needed funding had to divert their energies elsewhere.

One delegate from the social sciences summed up the frustration brilliantly: in Norway, all subjects are well funded by the research council. The ‘soft’ sciences don’t have to go cap in hand to team up with the ‘hard’ sciences in order to get funding for research. This could have been a real platform for engaging across the disciplines on equal terms, but instead – more importantly, at the last minute – the hard sciences were promoted. In practice, with soft-science-heavy projects abandoned, there were ‘floating’ delegates who found the remaining projects too far advanced to be able to accommodate them. The sage advice of the mentors (whom I do not think were entirely happy with the development, even if their professionalism gave nothing away) was to enjoy the last evening of working with wonderful people. But that is hard to do when just a few hours ago you thought you could save the world.

However, Forskningsrådet had two rabbits in their hat, and the first was pulled out at the end of day four: they would fund a ‘networking project’ to keep the contacts going from the idélab and to assess the projects and they unfold. This project had to have a PI from the social sciences or arts and humanities.

Day five was the big presentation day, and the presentations were fantastic. There were five projects which went to the final round. Of these, four received funding, for Forskningsrådet pulled their final bunny out of their hat – they’d found another 10M nok behind the sofa cushions. (As you do.)

Idélab 1

P is for projects. Delegates listening to the blurb from the leader as he prepares to announce which projects will receive financing from Forskningsrådet. (Comedy caption: ‘Get on with it, James!’)

So idélab had its ups and a down, and then more ups. The journey is not over. As a volunteer to co-PI the networking project it has not escaped my notice that we have gone entirely unmentioned by Forskningsrådet (and thus by the press) in their reports on the event. That is not to say that it is a dirty secret; indeed, for some of us it is the most important outcome of the event. Not because of the money, but because our research may show what so many delegates and mentors felt so strongly: that for real collaboration, and real change, support is needed from across the spectrum of disciplines.

Forskningsrådet, the leaders and mentors, not to mention the delegates, can congratulate themselves on a phenomenal week, and on some excellent projects. There is no shame whatsoever in seeking to improve on this success, and I hope the so-called ‘networking project’ can contribute to that, despite Forskninsrådet’s silence on it thus far. As well as excellent technological projects, what idélab showed is that Norwegian-based researchers are keen to work across disciplinary boundaries, that they understand that technology is meaningless without social change, and that they are keen to put this into practice. It is my hope that the ‘networking project’ can help to drive this change, already in the hearts of researchers, into the practice of research policy and funding.

Footnote: This review has taken me longer to write than any blogpost so far. I think this is partly because the roller-coaster journey is so difficult to capture in words. A pathetic excuse, but it is the truth. If you ever get the chance to attend one of these events, then grab it. It might just change your life.

*Update: I have now seen the following pages from the Norwegian Research Council, which clearly mentions the networking project: click here for English; click here for Norwegian (contains more details). And thanks to all for the emails sent – most reassuring. Let the change begin.

Two more blogs on Idélab (both in Norwegian):

Anja Røyne – Fysikk og Fascinasjon

André Fossen Mlonyeni on Forskningsrådet’s Idélab-blogg

Any others out there, then let me know!

Idélab 2

P is for post-its. Oh yes it is. Perhaps Idélab should have been entitled ‘101 ways to inspire ideas with post-its’. I jest, of course, but those things were useful…


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What does GLHFTTYL stand for?

Good luck, have fun, talk to you later

Might be used at the end of an online chat session. Combines the GL, HF, and TTYL acronyms.

"It was good chatting with you tonight. GLHFTTYL!"

Related Slang

Last Updated: February 10, 2014

GLHFTTYL definition

This page explains what the acronym "GLHFTTYL" means. The definition, example, and related terms listed above have been written and compiled by the Slangit team.

We are constantly updating our database with new slang terms, acronyms, and abbreviations. If you would like to suggest a term or an update to an existing one, please let us know!


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The Gist

Al Gore, Ever Hopeful

The former vice president returns with a sequel to his climate change documentary, An Inconvenient Truth.

Mike Pesca with Al Gore.

Listen to Episode 790 of Slate’s The Gist:

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members: Get your ad-free podcast feed.

If things had gone well, America would still be in the Paris Agreement on climate change, green energy would be spreading across the country and Al Gore wouldn’t have needed to make a sequel to An Inconvenient Truth. But it didn’t work out that way. With his new movie hitting theaters next week, Gore remains hopeful during these depressing times. “If somebody told me five years ago, marriage equality would be the law in all 50 states, I would have asked what they were smoking,” says the former vice president. “But it did happen, because it became a choice between right and wrong. That’s where the climate movement is now.”

For the Spiel, why persuading doubters is so hard when it comes to climate change science.

Join Slate Plus! Members get bonus segments, exclusive member-only podcasts, and more. Sign up for a free trial today at

Join the discussion of this episode on Facebook.

Twitter: @slategist