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COVID-19 Industry Medicine Uncategorized

Mr ACE2 Josef Penninger, Greatest Scientist of Our Time

As a young Wunderkind, Josef Penninger discovered the ACE2 receptor. Now he invented the cure for the coronavirus which will work in his hands where Big Pharma failed. He was never found guilty of research misconduct and never retracted a paper. Dr Penninger is a Genius making a COVID-19 vaccine.

There is hope for this horrible pandemic

Dr. Josef Penninger, April 2, 2020

Josef Penninger is a polymath scientist with many genius ideas but only two labs, on different continents. He is the biggest science star Austria has today, or maybe of all times. Almost 20 years before the COVID-19 pandemic, the magazine Esquire brought this prescient portrait of the young Wunderkind and his scientific genius:

The Greatest Scientist of Our Time

“Josef Penninger is thirty-six. He’s the son of Austrian farmers. He’s saved the world once. He’s on the verge of saving it again. And his greatest discovery is just around the corner. He’s going to save you.”

Little did they know back in 2001 that the now 55-year-old Josef Penninger will save the entire humanity from the coronavirus. And other diseases: cancer, obesity, heart attack, stroke. Everything.

Dr Penninger used to be director of the Institute of Molecular Biotechnology (IMBA) in Vienna, Austria,until the University of British Columbia in Vancouver, Canada made him a better offer. He does all of the biomedicine: virology, microbiology, immunology, genetics, cancer and cardiovascular research, neuroscience and brain diseases, regenerative medicine and stem cells, osteoporosis, diabetes and obesity, you name it, he solved it and published in Nature or Cell.

Much of Penninger’s research in the last decades was about the angiotensin converting enzyme 2 (ACE2), which was eventually discovered to be the target of the SARS virus, and then of course of SARS-CoV2, the COVID-19 pandemic causing coronavirus. Penninger is credited with discovering the ACE2 receptor in 1990ies. He explains about the SARS-CoV2:

Many, including myself, realized that the new virus is a very close sibling of the first SARS coronavirus. It was very clear to me that the receptor for this new virus would be ACE2, which I discovered as a young investigator in the 1990s, was a receptor for the first SARS coronavirus. For about a decade after the first SARS breakout, I was known as Mr. ACE2!

APN01, COVID-19 crusher

It seems, Professor Penninger has now found the cure for SARS-CoV2, published as Monteil et al Cell 2020. A soluble version of the ACE2 receptor, called APN01, was deployed on monkey Vero-6 kidney epithelial cells, and also on embryonic-stem cell derived clumps of vascular epithelium cells, or “mini-organs”, as Nature called them, and dramatically reduced the infection rate of the coronavirus. Penninger was quoted:

We are hopeful our results have implications for the development of a novel drug for the treatment of this unprecedented pandemic […] Our previous work has helped to rapidly identify ACE2 as the entry gate for SARS-CoV-2, which explains a lot about the disease. Now we know that a soluble form of ACE2 that catches the virus away, could be indeed a very rational therapy that specifically targets the gate the virus must take to infect us. There is hope for this horrible pandemic.

Clinical trials with the APN01 drug, patented by Penninger and marketed by his Vienna-based company Apeiron Biologics, started immediately in Austria (and another one in China). In Austrian media, Penninger said that this discovery finally brings him close to the long-deserved Nobel Prize.

A new promising drug, hurray, I hear you exclaim? Well, almost new. Second-hand, or pre-used drug, if you like. In 2010, same company Apeiron licenced same APN01 as therapy for acute lung failure to the pharma giant GlaxoSmithKline (GSK) for €239 Million, with €12.7 million paid upfront. Prior to that, a safety and tolerability trial for this drug was completed in Austria in 2009, but no results were posted so far. After APN01 was exclusively licenced to GSK, it became GSK2586881, for that there are 3 trials listed on One, done in Germany for “Acute Hypoxia and Exercise”, was terminated, not a good sign. Another refers to the two-part phase II trial by GSK in ten intensive care units in USA and Canada, and there is a relevant paper about that trial, Khan et al Critical Care 2017. It aimed to prevent lung injury in patients with acute respiratory distress syndrome (ARDS) and concluded:

GSK2586881 was well-tolerated in patients with ARDS, and the rapid modulation of RAS peptides suggests target engagement, although the study was not powered to detect changes in acute physiology or clinical outcomes.

GSK2586881 infusions did not result in improvement in physiological or clinical measures of ARDS“.

Obviously, GSK investigators were disappointed with the drug’s performance, because “continued recruitment was not justified, and the trial was terminated early“. As adverse effects were observed “hypernatremia; pneumonia; dysphagia; and, in particular, rash“.

That does not sound promising for COVID-19 therapy. Not really. I mean, knowing these results, is it really reasonable or responsible to continue treating COVID-19 patients, whose typical symptom and cause of death is ARDS, with APN01?

Yes it is. APN01 is being trialled once again, in phase 2 clinical trial on 200 COVID-19 patients in Austria (the Chinese trial’s permission was withdrawn, and no new one is registered). This time the trial’s sponsor is not GSK but Penninger’s Apeiron Biologics, a company with 20 employees. The reader may be confused here, since I wrote that 10 years ago Apeiron sold the “exclusive licence” on APN01 to GSK. How can Apeiron run trials with a drug they no longer own? Well, GSK gave the licence back in 2019, and it stopped being GSK2586881 and became Penninger’s drug APN01 again. They didn’t even bother to follow up on the data from their third trial with 23 patients, for pulmonary arterial hypertension, which results were posted in April 2020, long after GSK gave Penninger the APN01 licence back.

The Austrian visionary, eager to test APN01 for COVID-19, announced clinical trials in Germany and Denmark, in addition to Austria. He also spoke of his Monteil et al Cell 2020 paper:

The team’s findings hold promise of an early vaccine for COVID-19

In German media, the Genius has been quoted:

We know the drug is active and it is relatively safe, so you can use it. Now we have to test it on Covid 19 patients

Relatively safe”? Is this why the 2009 trial results were never released? [Update 14.10.2020: a knowledgeable source, “Joe Doe” with IP registering in Vienna, informed me rather tersely in the comment section today where these clinical results were published, several months after GSK’s phase 2 clinical trial started: Haschke et al 2013].

What about adverse effects and lack of clinical efficiency which GSK reported? Does APN01 only work when its inventor himself applies it? Why did GSK give the licence back, having paid so many millions? Is it a conspiracy of Big Pharma against the Genius? I think it must be, what other explanations might you have, dear reader?

Colon cancer gene and heart-eating bacteria

People call me and say, ‘I’m dying of cancer, can you give me that percent of this stuff comes through, that’s, enough. It gives them hope, and It should.

Dr Josef Penninger (2001)

Groundbreaking medical discoveries is what Dr Penninger does almost daily. Twenty years ago, Penninger discovered the cause and thus the potential therapy approach for colon cancer, namely the p110γ catalytic subunit of the phosphoinositide-3-OH kinase (PI(3)K). It was published in Nature, as Sasaki et al 2000. But in August 2003, a correction was published:

However, after backcrossing these mice onto a C57BL/6 background, we now find that the tumour phenotype has disappeared. Also, when we retargeted the allele in different ES cells using the same targeting construct, no tumours developed.

Which, dear failed scientists and layman readers, means in Nature-publishing academic circles that the main conclusions of this study are not affected. The German newspaper Zeit wrote in 2015:

“Penninger announced a sensation 15 years ago: he had found the gene that blocks colon cancer. Mice in which it was switched off fell ill. However, other laboratories were unable to reproduce the discovery, and other data were also criticized. Did he dribble too much? A commission cleared his team of all allegations. Penninger wept with relief, but the soil in Canada was poisoned.”

As it turned out, the investigation was performed not by a university, but by the pharma giant Amgen, which used to own the research institute Penninger and his then-boss Tak Mak worked in. The investigation happened after Mak accused Penninger of “cheating” who kept insisting that “Our mice got colon cancer. That we know. End of story“, as narrated in this article by MACLEANS magazine. Three scientists whose labs failed to reproduce Penninger’s colon cancer results submitted evidence in writing, but the Amgen commission refused to interview them. The records of the internal Amgen investigation are secret, but:

“The unanimous conclusion, announced to the University of Toronto medical community in June 2002: total exoneration. Penninger’s lab displayed “scientific rigour and good laboratory practices” and “allegations to the contrary were unfounded.”

For some reason, some months before that announcement Amgen completely severed its financial support for the Toronto research institute, while insisting that had nothing to do with Penninger affair.

It wasn’t just about the colon cancer in Nature. There was also heart disease in Science: Bachmaier et al 1999. According to MACLEANS:

Mak flew to Stockholm for a conference. Immunologists there were saying they couldn’t duplicate several Penninger discoveries. Then Hans Wigzell, head of Sweden’s Karolinska Institute, which hands out the Nobel Prize for medicine and physiology, challenged one of the discoveries that had made headlines. In 1999, Penninger said he had found the first biological proof that the bacterium chlamydia could cause heart disease. It was big news because scientists had long suspected a connection, but hadn’t been able to prove it.

But Wigzell was puzzled. His group had injected mice with chlamydia and hadn’t noticed any heart disease. Later Wigzell would retrace Penninger’s exact steps, even using a tiny bit of protein from Penninger’s lab. “We saw nothing,” he says. In Toronto, alarm bells were sounding. Why were so many scientists saying they couldn’t duplicate Penninger’s work?

Another Penninger discovery was that Helicobacter pylori, the bacterium which cause ulcers and cancer in the stomach, was also the cause of colon cancer, or so Penninger claimed, speaking of “a vaccination against colon cancer!”. The scientific community remained unconvinced, thus Penninger lost interest also and refused to publish on the topic ever again.

But mediocre losers, haters and failed scientists kept pestering the Genius. Penninger was quoted by MACLEANS with “People in other hospitals were emailing my [researchers]: ‘Oh, I hear you’re retracting your papers.’“. Luckily, science is self-correcting, and this is why no papers of Penninger’s were ever retracted. The chlamydia paper in Bachmaier et al Science 1999 was never even corrected, because there was no need.

Back then, Penninger was academically affiliated with the University Health network (UHN) and the University of Toronto , which he decided to punish by leaving in summer 2002, just when the Amgen investigation fully exonerated him and more than a year before the peculiar correction to his Sasaki et al Nature 2000 paper was published. The Canadian newspaper Globe and Mail reported:

But he told no one beyond a small circle of friends that he was prodded to go by what he felt was an assault on his reputation against which neither the UHN nor the University of Toronto faculty of medicine was defending him. He is an associate professor in the university’s department of medical biophysics.

Colleagues said he is also upset by a toxic relationship he had with his boss and former mentor, Tak Mak, 55, director of the Amgen Research Institute, which operated in UHN.

Conspiracies is what geniuses often suffer from their scheming detractors, and Canada’s loss became Austria’s gain. Penninger returned to Vienna to become the founding director of the newly established Institute of Molecular Biotechnology (IMBA). Maybe the pond was too small for such a big fish after all, because Zeit mentions that in 2015 Penninger was negotiating with the Max-Delbrück-Centrum in Berlin, to become the scientific director of that German institute. Unfortunately, the old cheating allegations from Canada were brought up again, which Penninger described as “unfair”. In 2018, Penninger returned to Canada, this time to University of British Columbia, under the elite Canada 150 Research Chair Programme, which recruits the best of the best in science. Professor Penninger now runs both labs, in Vancouver and in Vienna, very productively so.

We are now back in 2020. Just weeks after his COVID-19 breakthrough which of course will save the humanity, Penninger published another Cell paper, Orthofer et al 2020, which solved another plague of human civilisation: obesity. The Austrian polymath found the gene for thinness, ALK. This time, it will definitely be 100% reliable, unlike with the colon cancer gene or the heart-eating chlamydia. The solution to the obesity epidemic is nigh, Penninger already patented it: “The agent may be, for example, a ALK antagonist or inhibitor, or the agent may decrease the level of ALK in a cell“.

Guido and Josef, friends forever?

I myself, just as the next man on the street, sincerely hope that Professor Penninger’s discoveries, in particular APN01, are all correct and that all his envious haters will be proven wrong, put to shame and subjected to their due punishment, as severe as humanely possible. I mean, everyone says he is a genius, right? But then again, we are what our friends are.

One friend and scientific collaborator of many years is Guido Kroemer, German-born and France-based scientist and a star of cancer and ageing research. Together, the two friends planned already in 1998 to rid the world of cancer, heart and brain and all other diseases, by targeting the apoptosis gene AIF they together have cloned. It could have worked, maybe if enough Photoshop power was deployed.

Like Penninger, Kroemer was long considered a genius, but his reputation has been tarnished in later years what with the currently SIXTY papers flagged on PubPeer for data irregularities. Several of these papers were co-authored by Penninger, three of these were presented in this article, more follow below. The two friends are both members of the German Academy of Sciences, Leopoldina, and in 2008 they simultaneously received the prestigious Carus Prize from the Academy.

Right to left: Carus-Prize awardees Josef Penninger and Guido Kroemer, with Schweinfurt mayor Gudrun Grieser and Leopoldina President Volker ter Meulen. Original photo source: Mainpost.

I wrote about Kroemer before, in particular about his other best friends, the Spanish ageing scientist and martyr Carlos Lopez-Otin, and Didier Raoult, the French genius microbiologist who is presently also saving the world from COVID-19, but with chloroquine instead of ALN01. On 2 March 2020, Raoult and Kroemer proclaimed in an editorial:

Yet unconfirmed reports indicated that inhibitors of SARS-CoV-2 replication includ-ing chloroquine are clinical efficient against declared SARS-CoV-2 infection

The rest, as you know, is history happening before out very eyes.

In his own way, Guido Kroemer is the centre of the world. Which is why I will finally show you some papers Kroemer and Penninger co-authored.

Miramar DM, P Costantini, L Ravagnan, LM. Saraiva, De Haouzi, G Brothers, JM. Penninger, ML Peleato, G Kroemer , SA. Susin NADH oxidase activity of mitochondrial apoptosis-inducing factor Journal of Biological Chemistry (2001) doi: 10.1074/jbc.m010498200

Copy-pasted bands (see boxes and arrows), twice in one figure. Granted, it is a collaborative paper with Kroemer’s institute colleague in Paris, Santos Susin. There are four more Susin & Kromer joint papers which can be used as teaching material on what should justify an immediate retraction. The next paper has Penninger as last author:

Pospisilik JA, C Knauf, N Joza, P Benit, M Orthofer, PD. Cani , I Ebersberger, T Nakashima, R Sarao, G Neely, H Esterbauer, A Kozlov, C.R Kahn, G Kroemer, P Rustin, R Burcelin, JM. Penninger Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes Cell (2007) doi: 10.1016/j.cell.2007.08.047

Even if the gel was vertically compressed before accidental duplication which made it look different, Professor Penninger should still consider a correction. But then again, it’s just loading control, who cares, right? Not in Austria for sure. Same problem:

Perfettini JL, T Roumier, M Castedo, N Larochette, P Boya, B Raynal, V Lazar, F Ciccosanti, R Nardacci, J Penninger, M Piacentini , G Kroemer NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope The Journal of Experimental Medicine (2004) doi: 10.1084/jem.20031216

And other accidental gel duplication:

Vahsen N, C Candé, JJ Brière, P Bénit, N Joza, N Larochette, PG Mastroberardino, M O Pequignot, N Casares, V Lazar, O Feraud, N Debili, S Wissing, S Engelhardt, F Madeo, M Piacentini , JM Penninger, H Schägger, P Rustin, G Kroemer AIF deficiency compromises oxidative phosphorylation The EMBO Journal (2004) doi: 10.1038/sj.emboj.7600461

Three more Kroemer & Penninger papers, with rather unpleasant gel band duplications, were discussed in my previous article. But now I would like to show you some papers without Kroemer, but with Penninger.

The first one, in PNAS, proved something cool. Penninger, whose genius led him to discover simple causes for cancer, heart failure, or obesity has discovered that male aggression is controlled by just one gene: RGS2. The claim is bold, this is why it needed to be published without independent peer review, but “Communicated by Alfred G. Gilman“, where this member of National Academy of Sciences and two other friends he and Dr Penninger invited, gave thumbs-up.

Oliveira-dos-Santos AJ, G. Matsumoto, B.E. Snow, D. Bai, F.P. Houston, I.Q. Whishaw, S. Mariathasan, T. Sasaki, A. Wakeham, P. S. Ohashi, J. C. Roder, C. A. Barnes, D. P. Siderovski, J. M. Penninger Regulation of T cell activation, anxiety, and male aggression by RGS2 Proceedings of the National Academy of Sciences (2000) doi: 10.1073/pnas.220414397

Sure, this duplicated flow cytometry plot can be an accident. But why are the quantifications different, on the same file? More flaw cytometry:

Wada T, N Joza, HM. Cheng, T Sasaki, I Kozieradzki, K Bachmaier, T Katada, M Schreiber, EF. Wagner, H Nishina, JM. Penninger MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence Nature Cell Biology (2004) doi: 10.1038/ncb1098

Once again, why are the numbers different if the file was accidentally reused? Should not have happened if same setting were applied for all samples of the experiment. But then again, Nature journals are not that harsh in this regard.

Speaking of Nature. Gel splicing must be declared now, and in many old papers it is forgiven as historical. But in the following paper, the hidden splicing would make the entire result rather worthless. Except it doesn’t because the last author is Penninger, whose Nature papers from that era cannot be doubted (see above the Amgen announcement from 2002)

Bachmaier K, C Krawczyk, I Kozieradzki, YY Kong, T Sasaki, A Oliveira-dos-Santos, S Mariathasan, D Bouchard, A Wakeham, A Itie, J Le, PS. Ohashi, I Sarosi, H Nishina, S Lipkowitz, JM. Penninger Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b Nature (2000) doi: 10.1038/35003228

What is the point of the Spleen panel in Figure 1c, if all gels were done separately, and then spliced together? Same for Figure 5c, how much was really loaded of which sample and where? Why even presenting experimental data like this, instead of just drawing it with a felt-tip marker?

To conclude, a paper which was previously corrected, feel free to illustrate if for yourself.

Qi Y, X Tian, J Liu, Y Han, AM. Graham, MC Simon, JM. Penninger, P Carmeliet, S Li Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis The Journal of Cell Biology (2012) doi: 10.1083/jcb.201111063

A 2013 correction has been published:

“The actin panel in the original version of Fig. 5 B was flipped horizontally, and the Fig. 5 B and Fig. 6 C legends did not indicate the intentional duplication of the 3 and 4 d actin data. In addition, the HIF-2? panel in the original version of Fig. 7 C was a duplicate of the HIF-2? panel in Fig. 6 F. The authors have indicated that these issues were due to clerical errors during figure and manuscript preparation.”

Clerical errors. Bless you, Your Holiness. As the 20 year old Esquire article ended:

“Josef says science is better than the best Greek tragedy. It’s got everything. Blood and guts. Kids dying and people melting in front of your eyes. And the hero waiting in the wings to take you by the hand.”

Update 5.10.2020. A first life has been saved, or so all Austrian media reports. A COVID-19 patient was treated with APN01 by Professor Penninger and his colleagues on “compassionate use” basis, rather than as part of cumbersome clinical trials which Professor Penninger previously announced in Austria and other countries.

The female patient was treated presumably by the paper’s first author Alexander Zoufaly at the Kaiser-Franz-Josef-Spital in Vienna and published as Case Report in a Lancet journal: Zoufaly et al Lancet Resp Med 2020. The woman recovered, although the authors themselves are not entirely sure if at all thanks to the APN01 therapy: “Whether this decrease in viral load reflects the effect of hrsACE2 treatment or the natural history of the disease remains speculative.” There was also another patient treated, but not invited to the paper: “Of note, a second patient with severe COVID-19 symptoms received two doses of compassionate treatment with hrsACE2 for 1 day; however, because of the short term 1-day treatment, we did not include the patient in this Case Report.

If you are interested to support my work, you can leave here a small tip of $5. Or several of small tips, just increase the amount as you like (2x=€10; 5x=€25). I would like to buy as much of APN01 drug as possible, just in case.

5.00 €

12 comments on “Mr ACE2 Josef Penninger, Greatest Scientist of Our Time

  1. He must be right, because he has an asteroid named after him:
    It’s written in the stars.
    BTW, UBC is infamous for pimping its researchers. Could be the effects of a fondness for the famous “BC bud”.

  2. All you need to do is work for someone as famous as he is, get a paper in CNS or offspring, and presto! A great job! The reward justifies the means, right?

  3. “Josef says science is better than the best Greek tragedy. It’s got everything. Blood and guts. Kids dying and people melting in front of your eyes. And the hero waiting in the wings to take you by the hand.”

    I never liked Greek tragedies. Too sad and I always felt bad for Oedipus. I prefer comedies. Plus the last time in my field a kid died and melted by catching fire in front of someone’s eyes in the lab, it was a big scandal for a while and the PI got sued.

  4. Pingback: The secret COVID-19 cure of Pasteur Lille – For Better Science

  5. Hansi Burli

    WOW, Austrian here. Not following Penninger in particular, but never heard before that such allegations of irregularities were out there!

  6. “Is this why the 2009 trial results were never released?”
    Here they are:
    Not so hard to find actually
    And would you really think GSK would license in an unsafe drug? Or the authorities would allow further studies in critically ill patients?
    Can’t help thinking you have some personal beef with JP

    • Thank you Dr John Doe, I will update the article. Strange name you have for a resident of Vienna, Austria.
      That paper by JP (who you definitely cannot be, because, right?) was published on 17 May 2013
      However, the GSK phase 2 clinical trial began somewhat earlier, in September 2012.

  7. There are several ATP-competitive ALK inhibitors out there, mostly used to treat non-small cell lung cancer. A notable side-effect of a lot of them (alectinib, lorlatinib) is weight gain, not weight loss. I suppose this doesn’t necessarily invalidate JP’s research, but it’d be nice if someone could explain this counter-intuitive result

  8. Pingback: The Ballad of Claudio Hetz – For Better Science

  9. Pingback: Szyf and Rabbani: old gels evil, new genomics cool – For Better Science

  10. Zebedee

    Oncogene. 2004 Feb 26;23(8):1514-21. doi: 10.1038/sj.onc.1207279.

    AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

    Céline Candé 1, Nicola Vahsen, Ilektra Kouranti, Elise Schmitt, Eric Daugas, Chris Spahr, Jeremy Luban, Romano T Kroemer, Fabrizio Giordanetto, Carmen Garrido, Josef M Penninger, Guido Kroemer

    1CNRS-UMR8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille-Desmoulins, F-94805 Villejuif, France.
    PMID: 14716299
    DOI: 10.1038/sj.onc.1207279

    Problematic figure 5d. Much more similar after horizontal flip than expected.

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Tesla Inc. Chief Executive Elon Musk is urging employees to “go super hardcore” in the coming weeks in order to ensure a “decent” amount of vehicle deliveries this quarter, according to new reports.

regularly faces quarterly delivery crunches, but this one appears worse than usual. Citing an internal email they obtained, Reuters and Electrek reported Thursday that Tesla is facing a more challenging “delivery wave” this quarter due to supply chain problems.

“The end of the quarter delivery wave is unusually high this time as we suffered (like the rest of the industry) from extremely severe parts shortages earlier this quarter. This meant building a lot of cars with missing parts that needed to be added later,” Musk wrote, according to the reports.

“Early Q3 production was so challenging that we need to go super hardcore to make up for it over the next ~22 days to ensure a decent Q3 delivery number,” he added. “This is the biggest wave in Tesla history, but we got to get it done.”

In July, Tesla reported it topped $1 billion in quarterly revenue for the first time, and delivered more than 200,000 vehicles in the second quarter. But Musk at the time warned that the global chip shortage “remains quite serious,” adding that “the chip supply is fundamentally the governing factor on our output.”

Tesla shares have rallied 24% over the past three months, but are up just 7% year to date. The S&P 500
meanwhile, is up 6% over the past three months and nearly 20% for the year.

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Two visits in the space of seven days, it’s either because we have a gluttony for punishment or Bill’s is actually pretty awesome. Let’s go for the latter.

Bill’s has a very cosy barn house feel to it, with its rustic wooden seating, dried spices and herbs hanging from the ceiling, their own brand preserves cascading the walls and the ambient lighting.

Diners at Bill’s have an added twist to their visit. You can actually sit and order your weeks shopping from Bill’s whilst you savour the delights of their menu.

This morning on the rare occasions that Elena and I are awake before 12noon on a weekend we decided to head down to Bill’s for a spot of breakfast. We were in a ‘no disappointment’ mood so new we could go to Bill’s and have a good meal with minimal fuss.

I had the Eggs Royale and Elena had the scrambled egg with bacon. Both were served with the most delightful sour dough bread which is a break away from these dishes being served from a traditional English muffin but it works. The Eggs Royale on any breakfast menu is my fan favourite but this version/adaption has to be one of my fan favourites. The homemade hollandaise is so rich, creamy and tangy. I often get annoyed with restaurants about the quantity they serve of it but here I asked for a little more and they gave me a jug of it without any fuss. Look, I like my food hot and wet, so yes I asked for more.

They have a range of drinks at Bill’s but my fan favourite will always be the Elderflower cordial served hot. Never had I tried it hot until I was encouraged to do so by a waiter here many years ago and I haven’t looked back.

Bill’s may be a chain but boy is it a chain of happiness. The food can only be described as fusion food so you will find something for even the fussiest eater and to suit everyone’s budget. An average spend here for us would be £15 which is a rare thing these days.

Star Rating: ****1/2

9 White Lion St, London N1 9PD

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Virtual FI-HVC 2020

We welcome FI-HVC 2020 Teams.

We all know your team is waiting for the Final Event of Formula Imperial but due to pandemic it won’t be possible. Till this time we are keeping a hope of organizing Formula Imperial at Buddha International Circuit, Gr. Noida. Now, coming at this point we have to take the decision. So, Our Organizing & Technical committee has taken the decision to organize Virtual Formula Imperial 2020. As Every Team is learning new things from every event and there should not be any break in Learning. This will help teams in various aspects.

This can enhance their practical/theoretical skills as well as learn team management, so our engineering student will avail to face any hurdles in the way of real engineering. So we welcome all the enthusiasts to come forward to race, to participate, to invest for new era of hybrid technology and electric technology.

Virtual Rounds

According to the Decision by Organizing & Technical Committee, ISIEINDIA has taken a decision to organize Virtual Formula Imperial. We will be conducting all the Static Rounds as a part of Virtual Formula Imperial. Based on the same the Winner & Runner Up of the event will be announced.

About the Rounds

One or More Team members can participate. Maximum 5 members are allowed.Team members can present the report from different places.

Virtual Design Round: (150 Points)

Design reports submitted by teams before the deadline will be evaluated by our Technical Juries.

Every team will get the reviews from the experts accordingly they are required to make changes in the design report and submit it before deadline.

Virtual Innovation Round: (200 Points)

Teams are required to submit the Innovation Form with the full details of the innovation.

Innovations related to the sensors or innovations available in the market will not be considered.

Virtual Cost Report Round:(100 Points) Teams has submitted the Cost Report with the design report, further addendum is not possible. The Cost report should include the cost of every component that will be used for the vehicle.

Manufacturing cost

Name of Vendor/Supplier along with their address and contact details.

Virtual Business Plan Round:(150 Points)

The objective of the BPP is to evaluate the team’s ability to develop and deliver a comprehensive business model which demonstrates their product – a prototype race vehicle – could become a rewarding business opportunity. Teams are required to submit the B-Plan Presentation before the deadline.

People’s Choice Award:

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CEO pay continues unrelenting rise
by Diarmaid Mac a Bhaird

Executive pay in Irish-registered companies increased by an average of 6% in 2017, according to the second update of the Irish Congress of Trade Unions’ (ICTU) study Because we’re worth it. The report, which examines executive pay in 26 companies, found that “the upward trajectory of chief executive officer (CEO) pay continues unabated.”

The disparity between average earnings – which were €37,646 last year – and CEO remuneration is also growing. Report co-author Peter Rigney said the greatest variance between the average worker’s wage and their CEO’s was in building materials company CRH.

“It would take an average CRH worker 230 years to earn what its CEO took home in 2017. It would take nine years for the average worker to earn what the lowest paid CEO earned in 2017,” he said.

Fórsa senior general secretary designate and ICTU vice president Kevin Callinan wondered if any lessons had been learned. “The trend of senior executives in companies earning growing multiples of the average pay packet is unacceptable and is fuelling inequality,” he said.

Earlier this month, a survey by the respected journal Industrial Relations News found that the average private sector pay rise was between 2% and 3% in 2018.

The ICTU report’s conclusion notes that firms listed on the Dublin stock exchange are obliged to follow new guidelines by the British Financial Reporting Council (FRC), which come into effect in 2020.

It warns that: “it remains to be seen whether the effect of these new guidelines is to slow the rate of increase of corporate pay or merely to illustrate an unrelenting upward trend in greater detail.”

Read the report here.

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ChasePlane Presets Pack for FSLabs A320 Family 2.0

   (2 reviews)

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About This File

Accurate ChasePlane presets for FlightSimLabs A320 Family by A320 type-rated pilot.

This pack includes:  A319 / A320 / A321

What's New in Version 2.0

Complete rework of views and settings.

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   3 of 3 members found this review helpful 3 / 3 members

Please disregard the 2-star review above/below. These are the best ChasePlane configs for the A32x family available. As a person who dedicates myself to precise flying, I appreciate, approve, and recommend the configs uploaded.

There can be issues with various screen resolutions, but still, this is the best.

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   2 of 2 members found this review helpful 2 / 2 members

Beautiful , Thank you so much !

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Thank you!

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Official BS.Player forums

Go Back   Official BS.Player forums > Main forum > Answered And Solved Questions

Answered And Solved Questions A good place to check before you post your question. All answered / solved posts are archived here.

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Old 1st October 2009
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Default Hide message "REPRODUCIR" at "star/stop" videos??

hi people, somebody help?

Looping in repeat mode my playlist of some short video-arts,
I need erease or hide the default Bsplayer message "REPRODUCIR" at the start/stop of eny video of my playlist.

so Thanks !
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Old 1st October 2009
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(rightclick >) Options > Preferences > Video > [OSD]
Deselect/uncheck "Enable OSD"
Help2Help (click) BSplayer: simply the best & most versatile (Build 1072 Dutch language here!)
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madcow wepons /drop glitch!!

trying to finish a darkrp server.
for some reason when people drop grenades and knifes they get an extra one if they pick it up . is there a way to fix that or make player not drop grenades or knifes.

If you don’t want to touch your weapon base, then just remove one when they pick one up.

[editline]15th October 2011[/editline]

Also, I suggest you read this.

There’s not much we can do now, we need code and errors.

well i wouldn’t mind messing with it . it looks like when they drop it they lose the weapon but there ammo stays with them. theirs no errors that i see . i might make a vid to show what i am talking about.

So take their ammo when they drop?

i would make an if command to do that but i don’t know the drop command

[editline]15th October 2011[/editline]

ok i have it somewhat working. all i did was wen to the main.lua and under the dropwepon function i added this

[lua] ply:RemoveAmmo (1, “Grenade”) [/lua]

i just figured out that if another weapon had the same ammo type it will remove it as well so instead i did this

[lua] if ply:GetActiveWeapon():GetClass() == “weapon_class” then
ply:RemoveAmmo (1, “ammotype”)

and then i changed the weapons with the same ammo type so something different.

thank you guys for trying to help

Post your dropweapon function here please

Update your DarkRP version.

its already updated to the latest if you where asking me

the drop function is in the darkrp main.lua folder at line 384. some ware around there

Im not downloading darkrp just to fix something for you…

This was fixed in i231- Feb 19, 2010.

[editline]16th October 2011[/editline]

If you’re running vanilla it should work.

i already fixed it


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Hot damn, your posing is amazing.

wow, you’ve improved a ridiculous amount recently

good to see someone taking advice and getting better for once

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Interesting concept. Good execution and composition, although the light on the two troops is a bit confusing to me.

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cleaning my system and detox question

Discussion in 'General' started by xxkyorejectxx, Sep 14, 2009.

  1. okay so there is a drug test i have to go to in october, not sure when. and i need tips and help on cleaning my system or detoxing it. I was browsing when i saw this product
    "Premium Detox 7 Day Comprehensive Cleansing Program" does anyone know if this works. also can i use it now and be clean by October. (does it matter when i use it)
  2. I think on that it does not matter when you take it. It is ment to be a perminent detox solution. Better safe than sorry. The quicker you start detoxing the higher chance you have of passing it.

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Now that its all over...

Discussion in 'Real Life Stories' started by moshi1ry, Aug 11, 2012.

  1. I have tried to write this story down a few times but every time i never post it so hopefully this time it will be how i like it. To begin with there are a few things you need to know about me to understand my story.

    To begin with i grew up in South Carolina. South Carolina as a whole is a state that was first to succeed but it is always last to change and very religous...did i say religous? As a kid i was required by my parents who are and were very strict to attend church no matter what. Not attending or having faith was not an option in our house. While i might have looked like the little church boy who did nothing bad i soon came to realize that i could play that part but also have what my parents would consider a dark side. Soon as i progressed through highschool the lies became more and more maybe this is normal for kids. Somehow though i never got caught whether it was sneaking out for the night or just plain getting hammered (this was before i smoked).

    Senior year of highschool was a blast lots of drinking and having fun. I also played tennis and soon got good enough to where i had a chance to possibly play college. Eventually high school ended but i still kept 2 of my best friends for this story we will name them john and will.

    My parents wanted me to attend a small school i knew that. My mom is convinced im visually spacial challenged whatever the fuck that means haha. But i decided to go to a small private school not to mention it was very religous but methodist not baptist like i grew up in. My first few months in college were a drinking tennis blurr. Soon my first semester was over and it was time to go home. First night back my best friend will invited me to a party i made up some crazy lie and left for the night.

    As i entered the party a very particular smell something ive never smelled before hit my nose. It was weed and not only that the first time ive ever seen it smelt it or saw it smoked. Instantly i wanted to try it. And so i got high for the first time and maybe thats where some of my friends would say my obsession with growing started. I would have to argue though and say it was way before that when i wrote AND FAILED my presat essay section because i wrote on legalization instead of my topic. I only realized i had a topic when i asked a friend what they wrote about and they said the president and i said that sucks i wrote about marijuana :).

    Now to skip forward a little its summer time and getting close to my sophmore year. I have a girl friend playing college tennis everything looks to be going accordingly to my parents. What they dont realize and only my girl friend Carla realizes is i have become completely obsessed with growing. It may have been my first love truly if you can be in love with growing i was. I started to carefully calculate how i could pull this off while in college.

    My girl friend was never against the idea although she was scared i guess you could say she was the follower in the relationship. I had everything ready lights fans soil nuts seeds etc i had almost blown my entire summer pay check on it but everything was ready finally!

    I decided to grow this in my girl friends room primarily because my RA was a prick and out to get me. In the next few days i had my first sprout and boy was a tired and had no clue on the journey i was about to partake on. I started growing in the rubbermaid container underneath my girl friends bed in a dorm room. Keep in mind this dorm room is about the size of a large closet VERY small. For a while everything went as planned i had decided that to get a decent harvest i should move the plant to a friends place about 45 minutes down the road. I trusted him and he was my bestfriend we both needed the money to move out from our parents house and this could be the start of the money we needed. Oh and did i mention we both love to smoke?

    Its move day and my trunk has a pot plant in it. I have 45 minutes to drive down a rather busy highway and not get caught. Also I have to get the plant inside his apartment. I make the drive shitting bricks the whole way luckily it was a holiday and most people had left for home so we snuck the plant in easily. It took us about a day but we made a stealth dresser by taking out the back from one i found at a thrift store. I finally got my HPS light going and inline fan. Life is going good and im going to have a nice harvest.

    My friend decides hes going to leave for the weekend and told me he was going to see a friend so the plant would be alone for 3 or 4 days. I thought nothing about it and told him that was fine. Now what happened next ill probably never understand but my homemade carbon filter split in 2 while he was gone. It also just so happened that i was growing some very skunky stuff. My friend gets back and a few hours later he gets a knock on his door. Its the chief of police from his county and my friend has not had the chance to completely get the smell from his apartment. The chief says that they just arrested people 3 doors down from him with a pound of coke. They got a report that they smelled weed in the area (im pretty sure these people made up crap about us so there is not telling if they smelled it or not). The cop told him he would have a warrant to search his apartment on Monday.

    My friend calls me immediately freaking out like i have never heard before. We talked about burning it cutting it down putting it down the disposal everything. As badly as i wanted to do it i knew that i could not. Luckily the area he lives in is a bad area so there were no stake outs on his place. At about 3 in the morning i make the drive grab the plant and setup a very quick place to grow for a few weeks while this blows over.

    My friends place gets searched they find nothing and my friend just so happens to be on the tennis team with the chiefs son. Keep in mind this is a small town. The son convinces the dad nothing is going on and he regularly visits and is very good friends with my friend. We decide its time now to move the plant back down. Keep in mind this is the second time i have had the balls to drive a plant in my trunk for almost an hour. Lets not even begin on how this thing survived.

    The plant is in flowering and seems to be going perfectly as planned. I visit my friends house often now because i am so obsessed. Finally its time to have the chopping party. The buds were beautiful and it tooks hours of work getting all those sugar leaves off. I collect all the bud into a rubbermaid containter and drive back to the dorm. I am ecstatic because i have basically pulled off what i consider difficult to do. Growing in a dorm room at college while being a NCAA athlete oh and did i mention all the smoke i had :).

    I get back and what else would i do but party the night away. I decided i would worry about drying it the next day. Come about 2 in the morning after some drinks im pretty tired and decide to go to my girlfriends to sleep. I also had my car parked there so it made sense. Normally i throw rocks at her window and she comes and opens the door. Tonight thought something different was going on. Then as i stuck my nose up to the window....i smelled one of my favorite things but it made my stomach roll, it was my own weed. Which meant it was not in my car anymore and there is no filter. This is the skunkyest bud i have ever smelled and instantly i know its probably over.

    I am faced with two choices now as i watch from a tree across from her room. I could go inside her room and go down with her (i could already see the blue lights) Or run. I made a promise to her that if we got caught i would not leave her hanging. Longest walk of my life was walking to that room. The cop was banging outside of her room she would not let him in. I told him i was her boyfriend and just came to visit. He told me he was sure she had weed on her and then decided to search my person. My dumbass self forgot to toss the scale i had in my pocket during all this so next thing i know im in hand cuffs. The cop eventually got angry at my girl and busts down the door. What he finds was much more than expected.

    Eventually we go down to the sheriffs and all of the cops are having a party with this. 2 good kids caught with growing weed. Lets punish them! They weighed it out keep in mind this is stems and bud. I got marked down with 468 grams of weed. Roughly a pound. To this day i will never understand how it was a pound but it was apparently. Keep in mind its not cured and there is still some stem on there. Still a pound though means one thing felony. Not only 1 felony but i got 3 my gf got 4. We were charged with a 50k bail. Thankfully my parents are well off and payed it for both of us. 5k after bail bonds men. Which is ridiculous by the way (Rapist get a 50k bond...).

    To skip forward 6 months later i have a lawyer and get off on illegal search. Even though the DA wanted to punish me and make it into a big story he could not thank god to one dumbass cop with no warrant. I am back on my feet now while i lost a scholarship and so did my girl friend we are going back to school soon with no felonies. This was probably the wildest ride of my life and i wish i could write it all down better.

    Looking back on it, it was a crazy notion and probably not the smartest but in no way do i regret it. I love weed love growing it and seem no harm in smoking it. Sorry if this story is not perfect i will add to it if i can!
  2. whoa dude! thanks for the story, that was too real!
  3. Read it all and holy shit what a wild ride!
  4. ya thats intense, glad all worked out
  5. awesome.

    no sarcasm, growing like that; just awesome.
  6. So what do your parents think now? At that point they gotta just let you do your own thing,...
  7. Damn man. That's intense shit right there. Glad everything worked out.
  8. Damn dude that's fucked.

    That's an extremely sketchy gig you had goin, but I'm glad you came out on top.

    Do you grow now?
  9. [quote name='"Kobe4MVP420"']So what do your parents think now? At that point they gotta just let you do your own thing,...[/quote]

    I'm thinking the same thing, that was truly an awesome story
  10. Thanks for reading my story guys wasnt sure if anyone would be interested haha and sorry it was so long.
    My parents what do they think? I ask myself that same question alot probably because i built up for 20 years the image of a white hard working christian kid. I blew all that in a matter of 12 hours. First we never talked except when they yelled. Now i would say its better but being as how my parents are i think they see me as a bad kid as before they saw me being perfect. Hopefully the relationship will improve but its a hard spot right now.
    2. Do i grow now currently no...I love growing like you would not believe but i want to get my degree so currently i am not now. But it is hard

    I might post a few more details i left out earlier later.
  11. ok i'm a friend of moshi's and felt that this little summary did not do this story justice. I'm not will or john, i was actually left completely out of the above story... my friend had written this while blazed and i guess the guy who actually helped build both his grow boxes along with ghetto rigging his carbon filter to help keep his ass from getting caught... just didn't make the cut. I will rectify this glaring error. Let me recap what he said in the above post and give you my two cents:
    Everyone knows that SC is a fucking hick state and you can buy cigarettes, alcohol, and guns easier than pretty much any state. Not to mention his mom is a crazy bitch who would flip shit if she had known moshi knew what weed even was before this fiasco.
    I met the kid at school, but i've heard stories of him and high school and I have seen his drinking habits first hand. With these secondhand accounts along with firsthand knowledge it is safe to assume that high school was little more than a couple memories of girl's asses and tits that survived all that brain cell abuse.
    Our school is not small, it's fucking tiny. People drive by and don't even realize there is a school there. It's a small ass christian private school that can be accurately located due west of Bumfuck, Egypt. The RAs can be compared to a small, unqualified, commonly overweight group of police officers with no power. They're are the decent ones, the corrupt, and the assholes who think if they do not follow the RA handbook to the letter that the earth will spontaneously combust killing all the girls they will never have sex with. This bitch who was my friend's RA fell into that last group. She loved nothing more than to sniff out trouble. Dodging her with a sprouting plant would have been downright stupid. So my friend took it upon himself to grow in his girlfriend's room. He had researched stealth growing until he was pretty much the michael weston(pop culture reference, if you get it i respect you) of weed growing. He had tried to keep the number of people that knew of his little green child to a minimum so up until this point i had been left in the dark. I decided upon learning of the rooted love-child that i would treat it as my home and helped my friend to give it shelter in the form of a growbox we made out of his gf's school owned dresser. we ripped out the drawers and cut a hole in the back to hook up to the fan and carbon filter setup we made from chicken wire and ac filters. We had to do all this with no power tools and in near silence as we were in a college dorm surrounded by fellow students. The only part we got to use power on was the door as we needed a drill and had to use the school's drill which we stole from the art building. talk about sketchy. we were looking over our shoulders for weeks. Then we were on our way to his friend's apartment his car got a flat tire so we had to turn around and move a 3 foot tall pot plant from his car to mine in a parking lot within sight of the campus police station. i know i know, sketchhhyyyy. Thankfully the flat tire was our only mishap on the trip and we got the plant in his friend's place back in the dresser with minimal problems. after that we just had to wait til the plant budded. After we got the call that we had some cute little trichomes showing their heads we decided it was time to take what was ours from this little green prick that had caused so much stress. We cut him down and smoked the bud straight off the plant. not an easy process but it makes a nice tasty smoke that doesn't burn too hot. the plant was a mostly sativa hybrid so we had a nice head high and were really looking forward to seeing the finished product. little did we know in 24 hours time our whole world would be turned upside down.
    we get back to school and finally feel like we can relax a little, cut down bud is a lot easier to hide than a 3 foot tall plant... have a few drinks smoke a couple of cigars and whilst we were enjoying our stogies with a couple of buddies carla decides to call it a night. We stay up for a couple more hours then decide to call it a night. apparently while we were enjoying our stogies carla was trying to be a good gf and was gonna bring the weed in to the room to hang so it could dry. we had decided against this because of the smell, she was unaware and the smell attracted the unwanted attention of the police. they ask to search, she says no, they search without a warrant find the weed, my friends get off without a hitch.
    i was very invested in the whole process and besides moshi probably cared the most for the plant. i fucking love weed. seriously, it's unhealthy. I get high before work, before bed, before i brush my teeth, before i take a shit.... smoking for free was gonna be heaven. that all went out the window. i was worried they would find out i had been involved so i ditched my bowl, papers, and rolling machine in the trash. i was never interviewed or fingered as a suspect and now both my friends are cleared of all charges. i could have made this a lot better of a story if we weren't sitting here baked at our minds right now.
    I'll leave you with a few words of wisdom
    If yo lighter is broken,
    you ain't tokin

    if you love weed,
    it's the only thing you need

    Don't drive high
    that shit don't fly

    if the weed ain't green,
    fuck it it's still weed just smoke it.
  12. Didn't read that second long ass story but Michael Weston wouldn't have got caught..just sayin
  13. well if you read it you would see that it was not moshi's fault.
  14. You should be a fucking writer bro. That kept me entertained the whole time.
  15. Thats intense, good story. Happy you got out of it alright.
  16. Finally not stoned....nice read, and the second hand account is awesome

    Glad you learned something, never grow in confined spaces....and I'm happy your not a felon
  17. Holy fuck! You're the guy with the bike who steals Ivory in How High ;)
  18. Thanks guys for responses love my friends second hand account prolly more accurate than mine!

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Pirate The World - Online Adventure Game

Pirate The World Game Forums
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 Post subject: aww come on
PostPosted: Fri Aug 05, 2011 4:00 am

Joined: Sat Jan 06, 2007 4:26 pm
Posts: 124
the game is stalling constantly so I was forced to use a fame reset with the hopes that this issue is gone tomorrow.

To whomever is helping to keep this game online ...kudos
but it would be nice if the percentage calculations were lower for those of us who aren't getting anywhere do to lack of players and rediculous losses with that "stollen" option and the amounts that are taken when attacked is astronomical. upgrading isnt an option anymore unless you luck out on a high winning attack but those are high and few between.

I'd also like to complain about that spam crap in the forum..what's up with that?

 Post subject: Re: aww come on
PostPosted: Wed Aug 31, 2011 4:32 am
User avatar

Joined: Fri Feb 24, 2006 1:38 am
Posts: 726
Location: New Zealand
I'm not sure how the site is staying up but it is good. Because I've only been checking in a few times a month (If that.) I wouldn't know about the stalling but am happy to login and play to see if I have the same problem if you want me to. As for the spam I thought there was some spam filter that was put on the forums ages back but it doesn't seem to be working now. My post is quite pointless but is more just a 'hi' anyway. Figured I hadn't posted in quite awhile.

It angers me that bottles can say for you to shake well before use, but don't have to say to put the cap back on 1st.

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Thread: [Acknowledged] Entire bridge disappears.

  1. #1
    Join Date
    Jul 2017
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    [Acknowledged] Entire bridge disappears.

    A strange thing happened it might be a bug but I'm not sure, it seems when i move into a certain section a bridge i had built disappears, and when i move back it re-appears. I have enclosed a video so you might see this for yourself.

  2. #2
    Kickstarter Alpha Nomad
    Join Date
    Aug 2016
    The Netherlands
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    Problem the same as this problem.

  3. #3
    Member Maslostroj (Daniel)'s Avatar
    Join Date
    Jun 2015
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    ChicagoBob, thanks for the video, nice soothing voice you have.

    We know about this issue and will have to put a limit on how far buildings can stretch.

    What's happening is that your building is stretching across several terrain chunks (the chunk is a certain area and unit into which the voxel terrain is divided). There are only several chunks around you at a time and those further away are unloaded - when this happens, the building gets "unloaded" too.

    For now, we'd advise to shorten your buildings, or rather divide them into several smaller ones.

    Hope this helps a bit.
    "Well, I thought. This is how the world works. All energy flows according to the whims of the Great Magnet. What a fool I was to defy him."
    -Raoul Duke

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  1. I use kill -STOP PID but that means you need to get the PID first (ps aux or top works). kill -CONT PID resumes I'm guessing you're looking for an in-built option, not a way to pause the whole program though. As far as I know there's no commandline interface for Resilio.
  2. I was delighted to see that Resilio finally got an update ... and then worried when I read this: Is this true, can I no longer use Linux on a personal license? The changelog only mentions Windows Server, but the support article above looks like Linux is included as well ... i.e. every computer I own except my work computer. I use Resilio to sync my media library from my HTPC to my laptop and my backup system. All of these run Ubuntu on regular computers (i.e. non-Arm based). Should I be looking for some new software? I'd really love to keep using Resilio — I've been using it since it was Bittorrent Sync in beta. I did pay for a personal license. But there's no way syncing my media library is worth $30 monthly for a business license.
  3. Upgrade to v2.5.4 has trashed my resilio user account on two machines. Just upgraded both machines simultaneously, and both machines (one Linux, one OSX) dump me out to the account creation screen. If I create an account, none of my shares are there. On both machines, sync.dat went from about 65KB to 5KB in size. On the Linux machine, I was able to restore sync.dat from a previous backup. Any suggestions for the OSX machine, which doesn't seem to have a backup sync.dat file (and the sync.dat.old file appears to have been overwritten)?
  4. I would imagine that depends on whether you've installed it as a package from a repository or just downloaded the executable. Currently, the download from Resilio is a zipped executable, not a package, so the instructions are correct for the current "official" download. If you choose to install it through non-standard means, then you are responsible for understanding what changes that entails (i.e. knowing that a package from a repository is likely installed to the system PATH, and thus does not require the ./ which indicates running a file from the current working directory).
  5. The issue happened again last night. I've traced the problem to a failing drive controller on one system. When the controller drops out, a drive disconnects and causes files on the missing drive to be deleted from other connected peers. I've spent a few hours restoring the files tonight. With respect, I'm not willing to collect debugging logs for an issue that is causing file deletions. I've salvaged the regular logs from both machines and I'll submit them. I'm posting my support ticket here. This issue is serious, and needs to be publicly searchable until it is fixed.
  6. Did you ever resolve this? I lost 150,000 files in an untouched directory last night. It's the second time it's happened this month. I lost 45K files at the beginning of January. In both cases, I was able to restore from the Archive / other backups, but Resilio shouldn't silently delete entire directories with no notice, especially when those deletions can propagate. If I didn't get notifications about mass deletions, I'd be really pissed right now. I've loved this program since beta, but my confidence is really shaken here. I rely on Resilio to duplicate and back up my business files. I can't keep using it if this happens.
  7. Glad to see it. I'll be following through with a purchase shortly. Thanks for implementing this. It saved me writing a complex rsync script and seriously help cut down on system setup time.
  8. +1 Seeing this feature implemented would cause me to purchase Pro for my business. I'd really like to use BT Sync to propagate project directories locally from our storage server. Unfortunately, we are a mixed environment, so Selective Sync on Linux (and older OS X) is an essential feature for us. I understand the challenges of integrating with the various Linux GUIs (Unity, Gnome, KDE, etc.) Even picking one (Unity for Ubuntu / Mint support?) would be useful, but not essential. Many of the other non-GUI specific suggestions on this thread could work without requiring full GUI integration. Surely the file browser code from the Android app could be repurposed to permit Selective Sync via the WebUI? And, this could potentially have the added benefit of porting to the other OSes? Failing that, a whitelist or command line option, while less elegant, would at least put the functinality in place. Or ... ask the community for help? You are already crowdsourcing localization? Surely UI plugins are simple enough that they could be designed as open source plugins that utilize the API?
  9. So I discovered today that, at some point, my music share stopped being compatible with the version of BT Sync on my mp3 player (an old LG phone running CyanogenMod 2.3.7). No problem, I thought, just update BT Sync on the phone. Turns out, that's not possible — Android 2.x isn't supported on current releases. So ... my question is ... is there a version of Sync that supports the more recent share format (I assume this is the 2.x share format) that will run on old Android? I have zero interest in buying a new device just to run BT Sync, and I'd rather not have to run a separate Sync instance just for my music collection. Failing that ... is there a way to workaround version checks (possibly by back-porting newer libraries along with the install?)
  10. Wait ... does that include the direct downloads from the BTsync website? Or should I be going through their package library?
  11. Any word on when we will have this release available for Synology NAS?
  12. @EntropyEater / Daniel: Any portable device should not automatically list files that are available. If I'm crossing borders, or if the device gets stolen, I do NOT want whoever sees the device to see everything. I use multiple folders for a reason: Because access needs and device needs are different. Keeping all shares in one place is *removing* functionality for keeping things separate. @trbvm My guess is that 10.7.x support is related to this post: At least as far as I've been able to use Sync, support for Lion ended with 1.3.x ... any later versions will crash. Support Identified my crash report as being caused by incompatibilities with older versions of Lion.
  13. I have much weaker feelings on the pricing model than others I think. You want to charge subscription, that's your prerogative I guess. I see no need to insist that you offer a flat rate. At the same time, your decision is costing you my money. There are features in Sync Pro that I think are worth paying for, but I have decided to compromise and do without specifically because I dislike software subscriptions. My company dumped Adobe when they moved to a SAAS model, and there is plenty of other software that we don't use because it is subscription-based. So, I want your to know that the subscription model is specifically costing you my business. ------ Separate to that, I'm all in favour of new features, but my impression is that these new features have come at the cost of stability and reliability. I upgraded to 2.0 from v1.3.109 when it came out of beta because I assumed that dropping the beta tag meant you had eliminated all the problems introduced in v1.4. This does NOT make me want to pay for the software. Since upgrading, I've had more headaches with Sync than I ever had with 1.3.x. There are so many small, counterintuitive bugs that simply weren't there before. This isn't a place for bug reports, but, if you are trying to convince me that a subscription model makes for more production-ready software, your current record isn't convincing me.
  14. Word from BTSync support is that v1.4+ requires OS X 10.8 & above. However, I've had luck minimizing random crashes by freeing up hard drive space, eliminating shares that are also shared via SMB / CIFS, and not overloading the GUI with requests. It seems mostly stable unless I do something that is likely to stress the memory system.


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MZ-80K BASIC Manual

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MZ-80K BASIC Manual

Post by mz-80a »

I recently got hold of a copy of the MZ-80K BASIC manual and have scanned it (with OCR) and uploaded to my website. Useful for comparing some features between the 'A' and the 'K' perhaps. It's available here :
MZ-80A Secrets

Sharpworks (Sharp MZ homebrew)
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How to navigate admin panel user from a local plugin to a content-manager page?

Hi everyone!

I’ve implemented an appointment booking calendar UI as a local plugin (using Toast UI React Calendar) and would like to take advantage of the existing UI of the Content Manager plugin to create/update records.

My question is: how can I navigate the user to the “create record/update record page” from my plugin after the user triggers some event in my local plugin?

I’ve tried:
window.location.href = http://localhost:8000/admin/plugins/content-manager/collectionType/

But this results in a full page load, which is not very pretty.

Is there a React way of doing this? For example using react-router. I imagine I would need access to the content-manager plugin components and containers to do this.

Or is there a better way?


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Mr. Gray Project

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I was attending Geocoinfest Prague 2013, and I stepped away from my booth to go and watch the group performing ABBA, when I got back to my table Mama Mia! There was a Project My Gray #99 in my coin box! ~ :ph34r: #99

My link

Thank you very, very much for such a kind gift!

Hi avroair that is so cool that you got to go to another country and attend the event, wish I could of went to meet a few friends that I have been friends with thru the Geocaching community. Hats off to you and what a wonderful surprise to see that you got a New Mystery Mr. Gray Geocoin. Haven't heard anything of this project in a long time and nice to see he is still watching closely out in the adventure world. Glad that Mr. Gray was able to make you smile. Keep On Caching!

Edited by sweetlife
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Mr. Grey, could you please update me(us) on the current mission. I am not sure what I need to do to communicate with you. How do I get you my Earth dwelling address into your database to potentially get one of those special grey envelopes? Do I need to register with the MIB?

On a side note, did you agree with the demotion of Pluto from being a planet. I didn't know if you know any Plutoians that are mad about it from your travels. :)

I believe!!

Thanks -

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Scheduled message won't send

Once you've installed phpList... ask questions here!
Forum rules
Please help the volunteers to help you by supplying the version of phpList you are using, browser & version and if possible, a link to your phpList installation.

Scheduled message won't send

Postby JeffLeites » 3:33am, Mon 30 Mar, 2015

I go to the Finish Tab and click on Send Campaign, then I click on Process Queue.

When the Embargoed time is up, the message is not sent.

When I look at the Event Log, I see "You have 1 message(s) waiting to be sent".
I have to click on Process the Queue in order to send.
Why won't it send automatically?
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Re: Scheduled message won't send

Postby duncanc » 8:48am, Mon 30 Mar, 2015

phplist doesn't send automatically. Once the embargo time of a message is reached you then need to process the queue, either manually through the browser or using a cron job. The latter approach is best. If you schedule a cron job to run, say, every 5 minutes, then that is in effect automating the process.
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3rd Place Solution for Open Images 2019 - Visual Relationship

by content 16.08.2021

Authors: Roman Solovyev; Weimin Wang; Vladislav Golubev; Arthur Stsepanenka; Nikolay Sergievskiy

Abstract: In this technical report, we discuss our 3rd place solution for the Visual Relationship track of Open Images 2019 competition. Specially, we demonstrate the effectiveness of using two models - ‘Relationship Model‘ and ‘Attribute Model‘ - to solve the task. In particular, for the ‘Relationship Model‘, we have shown in our results that leveraging on the high quality bounding boxes of individual objects, a gradient boost based model can achieve very good performance of predicting pairs of relations between objects based on carefully designed geometric features extracted from those individual boxes.


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Town of Natick Advertising For Health Director

Share, email, print, bookmark SOURCE reports.

NATICK – The Town of Natick, along with the City of Framingham, are both now advertising for Directors of Public Health.

The Town of Natick is seeking highly qualified candidates for the full-time position of Director of Public Health.

The position is responsible for administration, managerial, technical and inspectional work related to enforcement of Public and Environmental Health Federal, State and Local laws and regulations.

The starting salary will range from $95,000 to $115,000 annually, depending on qualifications and experience.

Applicants should have a minimum of 5 – 7 years of work experience in the field of public/environmental health, 2 years of which should have been in a supervisory position; preferably in public health municipal management in Massachusetts.

The Natick Director of Public Health: works in conjunction with the Town Administration and under the policy direction of the Board of Health.

The director supervises a staff of eight full-time employees, one and one half grant funded positions, and a part-time food consultant.

Applicants are required to have a Massachusetts Certification as a Registered Sanitarian or National Environmental Health Association Certification as a Registered Environmental Health Specialist/Registered Sanitarian, Certified Title V Soil Evaluator

Interested candidates should submit a cover letter and resume to or apply online at

Natick said a review of applications would begin immediately.

email: call or text at 508-315-7176


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Grande fête de la Francophonie

Grande fête de la Francophonie

This event is organized by Smithsonian at 8 and the Francophonie DC Festival.
Francophonie Festival celebrates the diversity and richness of the French language and francophone communities around the world.

All you need to know...

WHAT: Grande fête de la Francophonie

WHEN: Friday, March 23, 2018 – 7pm-11pm

WHERE: La Maison Française – 4101 Reservoir Rd, NW - Washington, D.C. 20007

RESERVATION: Online registration required on Evenbrite.

ADD. INFOS: Valid ID required. No parking inside the embassy. No large bags, helmets and suitcase.

Presented in collaboration with Francophonie DC and La Maison Française at the Embassy of France.

Closing celebration of the 2018 DC Francophonie Cultural Festival

Get ready for a spectacular party with a French accent. The annual Francophonie Cultural Festival spotlights the music, art, literature, film, cuisine, and customs of French-speaking countries and regions from across the globe. Its closing celebration, La Grande Fete, is always magnifique, and this year’s bash is no exception.

Beginning at 7 p.m., launch into a world tour of francophone cultures. Sample food and drink from more than 30 embassies as you explore each nation’s unique attractions and traditions. Share your experiences throughout the night on Instagram using #at8enfrancais.

DJ Princess Slaya spins music from Africa, the Caribbean, Europe, and plenty of destinations in between. Don’t miss this chance to experience the best of the French-speaking world—all without leaving home.

Participating organizations and embassies will be announced at a later date.

For Embassy security purposes, all guests names must be provided at the time of registration. The name on your confirmation should match the name on your ID. If you wish to give your ticket to someone else, please update your registration information on Event Brite at any time. No guests will be allowed entry if their names have not been submitted in advance. IDs will be checked at the door.

Please Note:

  • Tickets must be purchased in advance (no sales at the door).
  • Tickets include admission and food and drink samples from 7 to 9 p.m.; a cash/credit bar provided by Tortoise & Hare Bar and Grille is open throughout the night.


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American Premiere : "Tsvetaeva"

American Premiere : "Tsvetaeva"

This event is organized by The Russian Chamber Arts Society.
The three-part vocal cycle for mezzo-soprano and baritone dedicated to the 125th anniversary of a legendary Russian poet Marina Tsvetaeva

All you need to know...

WHAT: American Premiere : "Tsvetaeva"

WHEN: Friday, October 12, 2018 ‐ 7:30pm - 11:30pm

WHERE: La Maison Française – 4101 Reservoir Rd, NW - Washington, D.C. - 20007

General Admission : $55
VIP : $85

RESERVATION: Online registration required on InstantSeats

ADD. INFOS: Valid ID required, no parking inside the embassy. No large bags, helmets and suitcase.

This vocal cycle for mezzo-soprano and baritone in three parts — Poet, Love and Marina — is dedicated to the 125th anniversary, in 2017, of the birth of Marina Tsvetaeva, whose tragic life ended in 1941.

Set to her powerful and influential poetry by acclaimed Russian composer Alexander Zhurbin, who will attend the performance, this American premiere will be sung by Magdalena Wor and Timothy Mix, accompanied by pianists Genadi Zagor and Vera Danchenko-Stern, RCAS founder and artistic director.

Magdalena Wor - mezzo-soprano
Timothy Mix - baritone
Genadi Zagor - piano
Vera Danchenko-Stern – piano

Tickets are $55, including a post-concert reception with the artists.
VIP tickets, which also include a champagne reception at 7 p.m., are $85.


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You Can Get With This or You Can Get With That . . .

You can get with this or you can get with that. But you can’t do both.

The world today is filled with many voices all competing for our attention.  Books, podcasts YouTube Videos, webinars, meetings and the like are jockeying for position in between our ears or in front of our eyes. Attention is the new commodity according to Gary Vaynerchuck, who day trades attention.

Each of these voices has something significant to offer and each is speaking a truth but is that truth or offering good for you?

Do you follow someone because their words ignite something within you? Do you follow because someone you know follows them? Do follow because they followed you and you are being polite by following them back? Do you follow to get more followers? Do you follow what I’m saying?

Listening to or “following” many different voices can be difficult and confusing. Each voice has a different point of view which may be the reason that many listeners or followers are stuck or unstable in their endeavors. One voice says, “Do this.” Another voice says, “Do that”. The listener/follower is now torn between two opinions. “No one can follow two opinions. No one can follow two voices.

Which voice is right for you? The voice to whom you give your attention must speak truth. Truth that is true for you. That voice must nourish your growth. That voice must help you reach your destination (your destiny) and help you fulfill your purpose.

It’s time to consider and audit the books, podcasts, videos, the meetings, and webinars to whom we give our attention. It’s time to delete and discard those voices that don’t take us where we want to go. It’s no fun realizing that you missed your turn because you weren’t  listening to the right directions. Listen to and follow those who are going your way. Do it today. You don’t have time to be on the wrong road. #Whatsonyourplaylist

One Action

We are one action away from accelerating our success or propelling our failure.  Just one action can change the entire course of your life. Your family, health or company.

The story that comes to mind of Nike. You know them, the big athletic apparel brand. They had a major influencer on their team in Stephen Curry, (of the Golden State Warriors). Steph wanted to put his mantra, “I can do all things” on his shoe. This comes from the bible verse in Philippians 4:13 that says, “I can do all things through Christ that strengthens me.”

Nike took one action and said no. Steph Curry took one action and went with another company that told him yes. Under Armour took one action and said yes. And now that brand influencer is on their team.

One action cost Nike a major endorser. One action gained Under Armour a major endorser.

What’s your one action that will change the course of your life?

Read the Faithit article here:

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