text:
An enactive approach to language and mathematics

FWO/NWO onderzoeksprogramma 2015 t/m 2018
Dutch Title: Woorden en getallen zonder franje. Een enactieve benadering van taal en wiskunde.

Current mainstream theories about the human mind and cognition model the human mind as
analogous to a computer. In these models, the natural, social and cultural environment of the subject
play only a secondary role. However, radically different views of the mind have always led a more or
less undercover existence both in philosophy and psychology. In recent years, these views have reemerged
under the banner of Embodied and Embedded Cognition (EEC). The Enactivist approach –
the most radical alternative to mainstream theories that falls under the banner EEC – argues that the
human mind emerges out of, and is constituted by, active engagement with the environment. An
advantage of such an approach is that it takes on board the idea that cognition takes place in, and is
shaped by, a network of social and cultural practices. Cognitive scientists and philosophers have
shown that replacing the computer-metaphor with a view of the mind as embodied active engagement
pays off in explaining such basic capabilities as perception, memory and basic social interaction. The
aim of this research project is to extend the Enactivist approach by showing how symbolic activities, in
particular language and mathematics, can arise from embodied active engagement with the social
environment, which currently presents the greatest challenge to EEC. The new branch of science
called bio-semantics is going to play a major role in the execution of this programme.

Fonds Wetenschappelijk Onderzoek (FWO) Vlaanderen,
Lead Agency: Onderzoekssamenwerking NWO (3)
Dossier G0C7315N

Ingediend door:
Prof. dr. E. Myin (Universiteit Antwerpen)
Prof. dr. F.A. Muller (Erasmus Universiteit Rotterdam).

Vlaams-Nederlandse samenwerking. Gehonoreerd. Bekend gemaakt door FWO op Woensdag 19 November 2014. Bedrag: 273 kE.
Behelst: postdoc K. Zahidi (Antwerpen) en promovendus  J.C. van den Herik (EUR).

The Digital Turn in Epistemology

NWO Onderzoeksprogramma
2018 t/m 2022
Dutch Title: De Digitale Wende in de Kenleer

Embodied, Embedded and Extended Cognition (E3C) marks the recent turn in Epistemology, the philosophy of knowledge. The three adjectives indicate that our knowledge and capacities are not located in our skulls, but extend to, and are distributed over: (i) our bodies, which are always embedded in their environment they interact with; and (ii) the artefacts we use, varying from paper notebooks to computers. E3C holds that practical knowledge is primary: subject S knows how to perform an action, and that the other kind of knowledge, propositional knowledge, derives from it phylogenetically and ontogenetically — subject S knows that p. The mediation of knowledge acquisition by ICT is becoming so dominant and ubiquitous (smartphone, tablet, laptop, computer, world-wide-web) that Epistemology must take, after the E3C turn, a further, digital turn.

 We concentrate on the following epistemological questions that obtrude: How to make sense of mathematical knowledge after the turn in epistemology to E3C, given its abstract character? Does the digital turn affect the genesis and essence of mathematical knowledge? When practical knowledge is primary and propositonal knowledge is derivative (E3C), how does this ‘derivation’ work in a digital environment?

 To answer these pressing philosophical questions, an empirical case study in epistemology will be performed of the acquisition of mathematical knowledge and capacities in a controled ICT-embedded environment — also because the acquisition of these sorts of knowledge and capacties are exact and testable. Moreover, the flexible ICT–tool that this Project develops will also be of great service in mathematics eduction at secondary schools.

The purely philosophical project of inquiring into the effects of the E3C and digital turn in Epistemology on our understanding of what mathematical knowledge is lies in the hands of Daan Dronkers, since 1 February PhD at our Faculty.

Hoofdaanvrager: Prof.dr. F.A. Muller
in samenwerking met: dr. J.M. Broersen (Faculteit der Geesteswetenschappen, Universiteit Utrecht)
                                       dr. A. Bakker (Faculteit der Natuurwetenschappen, Universiteit Utrecht)

Programma heeft drie promovendi: ieder van bovengenoemde begeleidt er een.
Samenwerking tussen de EUR en Universiteit Utrecht
Gehonoreerd. Bekend gemaakt door NWO in de herfst van 2016.
Bedrag: 1 ME.


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text:
Public Release:

Guam rhino beetles got rhythm

University of Guam

In May 2008 the island of Guam became a living laboratory for scientists as they attached acoustic equipment to coconut trees in order to listen for rhinoceros beetles. A grant from USDA IPM allowed Richard Mankin, a recognized world-class expert on acoustic detection of insects, to travel to Guam to collaborate with island scientists on the Guam Coconut Rhinoceros Beetle Eradication Project. The results of this research were recently published in the journal Florida Entomologist.

The coconut rhinoceros beetle, Oryctes rhinoceros, is a serious pest of coconut palms and was discovered on Guam September 11, 2007. University of Guam entomologist, Aubrey Moore worked with Mankin to analyze the spectral and temporal patterns of stridulations produced by the rhino beetles. Recordings were made of beetles and larvae that were reared at the university. Field recordings were also made of beetles and larvae in coconut trees and logs.

Digitized signals were analyzed with several types of software, which distinguished intervals and amplitudes of chirps. The stridulations have distinct, easily recognizable temporal patterns. Results of these studies favor the hypotheses that beetles use stridulations to communicate with other beetles in hidden environments and that acoustic monitoring devices can be useful in mitigating the damage to coconut trees through monitoring and early detection.

"This method of acoustic detection allowed Guam 'rhino hunters' to quickly and efficiently locate feeding grubs in an area thought to be rhino-beetle free," says Aubrey Moore, "and as the beetle broadens its range the acoustic approach to detection may save money and the lives of many coconut trees."

Mankin, R.W., A. Moore, P. R. Samson & K. J. Chandler 2009. Acoustic characteristics of dynastid beetle stridulations. Florida Entomologist 92(1): 123-133.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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text:
Web-Enabled Lotus Application

Posted on 2004-08-29
Medium Priority
Last Modified: 2013-12-18
Where can i find tutorials or articles that can guide me in web enabling my lotus application?

I have a background in Lotus Notes database running in Notes environment only but i have zero, as in zero, idea on how to develop web-enabled applications.

Please send me some dummy's guide or advices from you gurus on the above topic.

Your prompt replies will be much appreciated.

Thanks a lot in advance.
Question by:makuletski
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LVL 15

Expert Comment

ID: 11928861
Check out the redbooks section of the ibm website :

LVL 19

Expert Comment

ID: 11929140
You can web enabled Lotus Notes database easily with few steps.
Any Lotus Script won't run(All UI), so run it through agent and call it in WebQueryOpen/WebQuerySave.
Some formulas won't work. like: @IsDocSaved, etc.,

just let us know what type of application u want to web enable.

Author Comment

ID: 11929398
Redbooks are too advanced...do we have other sites or materials which is more simple?

What are the easy steps you're referring to?

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LVL 19

Expert Comment

ID: 11929418
you can directly open Notes forms on web.

if the the form is not displayed, then you would be using @DbLookups/dbcolumns. Remove them and test.
AND don't use any Scripts. call then through agents.

u should be familiar with Java Script and HTML.

Thats why I want to know the basic concept of your database. is it very huge?

U can copy the notes form and name it as $$ViewTemplate for yourformname. alias should be the formname which ur using in notes.

Open the $$ViewTemplate for yourformname on web and look for result.
and for views:
$$ViewTemplate for yourviewname.

or for views create a $$ViewTemplateDefault form and place a field in that (call $$ViewBody)

u can play with this. check for notes help for more info.
LVL 19

Assisted Solution

RanjeetRain earned 100 total points
ID: 11929940
My experience is that the RedBook by IBM on R4.6 is the best reference on the subject. However, feel free to read this online book. Relatively much easier reference.

LVL 24

Expert Comment

ID: 11930582
Check this tutorials from lotus

LVL 31

Accepted Solution

qwaletee earned 200 total points
ID: 11931875
The most important thing is to first work on a relatively simple app that was developed from scratch (not based on a discussion template or anything similar), and that you know well.  Try it out on the web, and slowly start tweaking things that either don't work at all, or are awkward on the web.

Here are the basic things to know:

1) All databases are automaically web enabled, the question is whether they work well on the web

2) Views/folders work pretty well, but they are very "basic" and don't really provide a good web page by themselves.  The "view template" forms (read up on $$ViewTemplateDefault in the designer help) provide a web page to "enclose" views.

3) All field formulas work OK

4) ****Most**** simple formula buttons/actions/hotspots work OK

5) LotusScript events and buttons/actions/hotpots do not work at all.  Instead, you develop "Web Query Save" and "Web Query Open" agents, which we won't talk about just yet.

6) Hide From Web / Hide From Notes is your friend -- whther in a form (paragraph hide when) or as a complete design element

Author Comment

ID: 11948332
How about html and javascript?...What is its connection with web-enabled applications?

Thanks :)

LVL 19

Assisted Solution

madheeswar earned 100 total points
ID: 11950876
Javascript is used for Validations. and HTML tags are used for formatting, links,etc.,
LVL 24

Assisted Solution

HemanthaKumar earned 100 total points
ID: 11952915
sometimes you can use form or page in notes as simple html file with html and js code in it. Or parts of html and notes elements. Ultimately Domino converts and treats each design element requested by browser as html file. Different is that when you submit the form, the html elements are saved to notes record as fields/data
LVL 31

Expert Comment

ID: 11957312
HTML and JS...

Web browsers do not understand anything else!  They don't know anything about Domino.  So, Domino generates a page containing HTML to represent a particular piece of a view or folder, or to display a particular form/document.  HTML is not programmable, it is a language for displaying formatted information, collection data in fields, and pushing the field data to a web server on submit.  Domino adds some Javascript automatically to most pages, to make this process a little easier for itself (e.g., so it can tell whether the user pressed a button labelled SUBMIT or CANCEL).

Sometimes, what Domino generates isn't "good enough."  For example, users don't like the way validations work -- you get the error message in a new page, and haveto press the BACK button to get back to the data (and sometimes, the data disapears when you do that).  So, programmers sometimes add Javascript to pre-check the user's input BEFORE submitting the input to the server.

Or, you might have a little UI in Notes that pops up a box (@DialogBox) to guide the user through some questions, and puts the results back in simplified format on the main screen.  The web doesn't have this, so you can code your own HTML and Javascript to simulate that.

I use lots of "little bits of HTML" to improve Domino's formatting, and the occasional bit of Javascript for a more dynamic experience (DHTML, validations, pop-ups), but I try to avoid it.  Why?  A big part of the beauty of Domino is that you get decent stuff done quickly in Notes, with minimum of time, effort, cost, and fuss.  You get a lot of the same with the browser.  But once the sponsor starts asking you to fiddle with it a lot to make a cleaner interface, it starts getting bogged down, and the costs, time, effort, and fussiness can easily triple.  At that point, Domino has lost much of its edge, while still leaving youwith Domino "baggage" (non-relational, non-locking, platform density).

Author Comment

ID: 11969753
qwaletee, thanks for that great explanation

maddy and the others, tnx as well...ill be venturing into web enabled applications soon and i hope i can still count on you guys for help

tnx again!!

Author Comment

ID: 11969759
oh!! i forgot to ask...how about webspere? what is it all about?

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When trying to change windows dreamscene background explorer.exe crashes and restart.

Posted on 2007-11-14
Medium Priority
Last Modified: 2010-08-05
hi experts.

I am running windows vista ultimate edition.I installed windows dreamscene as an ultimate extra.
Dreamscene(video background) worked,until recently.
now when i want to switch on dreamscene via "change desktop background" an error message appear telling me that explorer.exe crashed and has to be restarted.I am running mcafee with the latest dat files and found no sign of spyware or viruses.the system is an amd am2,with 1 gig ram and onboard nvidia graphics.i also downloaded all the updates from microsoft,bt the problem persists.

any hep would be greatly apreciated.
Question by:raiden69
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Expert Comment

ID: 20284992
Seem to be related with video drivers, are you upgraded codecs or something?

Author Comment

ID: 20326516
actually wasnt codecs but the problem seems to be fixed now.apparently someone messed around with dep (data execution prevention).restored it to default and everything is fine now.explorer isnt crashing and dreamscene is running smoothly

Accepted Solution

Computer101 earned 0 total points
ID: 20965863
PAQed with points refunded (250)

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Premiere Pro - Project Window

Posted on 2013-05-25
Medium Priority
Last Modified: 2013-06-21
Has this ever happen to you.  Your trying to select clips to add to a timeline but software won't let you select clip.  It keeps asking you if you want to import; subsequently, you import clip and the same thing happens again.  When you try to select single item, it won't let you.
Any ideas?  Also, if I try to select muliple clips, I get the crosshair mouse icon - like I want to crop a photo or something.  I know that clips are imported already. This makes no sence...
Question by:JZeig
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LVL 70

Expert Comment

ID: 39198465
Well I'm not a user of Premier Pro but it's similar to Power Director 10 and most other good quality video editors, the only time I have seen this is if I drag to the audio time line or video timeline 2 instead of one.

First take a look at the time line, note there is audio time line video time line,
In my PDD I have Video time line 1-2-3 up to 10 same with the audio line
Make sure your dragging from the bin to a video timeline.
There is also copy and paste
The Timeline - Adobe Premiere Pro CS5 Video Tutorials
Adobe Premiere: Three Ways To Add Clips To the Timeline
Arranging clips in the Expert view timeline

Author Comment

ID: 39201218
I don't think the problem is with the timeline.  It's with the project panel itself.  I can't select individual clips from the project panel and drag to the timeline.  If I click and hold down the mouse, it change to the cross + as if I was going to crop a picture.  At that point I can select as many clips as I want, but when it come time to drag to the time line, I can't use the mouse to drag the clips over.  Now if I change to thumbnail view, the system allow me to drag-an-drop whatever I want - which is what I've been doing....
LVL 70

Accepted Solution

Merete earned 1500 total points
ID: 39203559
There is a few possibilities as to what is causing this, what is in your source monitor
By default when you drag a clip into a Sequence from the Source Window you perform an Overwrite Edit.  If you’d like to perform an Insert Edit instead (pushes other clips down the timeline) hold Control when you drag the clip to the sequence.
Often you will want to rearrange the order of clips in a Sequence.  Select the clip, drag the clip to a new location, then hold Control + Option/Alt before you let go of the mouse (make sure snapping is turned on). This is called a Swap Edit.
May have something to do with the play head, in thumbnails view Adobe can see the video play header,
 could also be related to the scrubber, if you have that enabled,
explained here
Working in Icon view
 Video tutorial: Hover Scrub
and here
does it have audio with it?
Drag/Drop Video Without Audio Track
Change Project panel views

Author Closing Comment

ID: 39265721
I don't know exactly what happened, but the problem has seemed to fix itself...
Thank you for your help...
LVL 70

Expert Comment

ID: 39267415
Thank you glad it helped somewhere lol

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Windows Vista shutsdown when I close the lid, but then starts again

Posted on 2013-06-12
Medium Priority
Last Modified: 2016-11-23
I have the setting enabled that when I closet he lid on my my Dell Inspiron 1525 laptop, the computer is to shutdown.

When i do close the lid, the computer does a complete shutdown, only to reboot itself, and I can hear the "welcome to windows" chime (with the lid still closed).

How can I solve this problem?
Question by:LessonsLearned
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LVL 98

Expert Comment

by:John Hurst
ID: 39243046
In Windows power management, there are two settings for Lid Close: One for AC (plugged in) and one for Battery. Did you set them both?

Is there a Dell Power Manager that need to be set or otherwise disabled.

Also, if Lid Close is to shut down, you may wish to disable Sleep options as they might conflict with this. This is an unusual setting. By disable Sleep, I mean set the computer to be always ON both AC and Battery.

Finally update the PM driver in Vista and any third party Power Management software.

.... Thinkpads_User
LVL 13

Accepted Solution

lauchangkwang earned 2000 total points
ID: 39243136
Maybe you can try another power plan, either customize yourself again or from the default, then see how it goes.
LVL 93

Expert Comment

ID: 39243600
if the above don't help - look for a bios update, it can help in such cases
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Author Comment

ID: 39249084
I changed all the settings to shutdown, everywhere I could find.
LVL 98

Expert Comment

by:John Hurst
ID: 39249122
Did you update the PM Driver, Power Management Application and BIOS as suggested above?  Also update the Chip Set Driver if you can.

It is possible your computer does not support Lid Turn Off (even though Vista might support). I have never seen this done, and I don't think it is very common to use the Lid to shut down.

... Thinkpads_User
LVL 93

Expert Comment

ID: 39249638
did you look for any bios updates, that address the problem?

Author Closing Comment

ID: 39261002
I used the "advanced" section to customize the power plan.

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RDP connection from XP to Windows Server 2003

Posted on 2013-06-16
Medium Priority
Last Modified: 2013-12-28

I have a domain user who can't RDP from a specific Windows XP machine into a Windows Server 2003 with Terminal Server running. I'm getting error message "The system could not log you one, make sure the user and password are correct".

I tried the following;
- changed the user's password
- changed the xp computer name
- changed the xp ip address
- created new test user on AD, also not accepted
- restarted both DC and TS Server

Any ideas is greatly appreciated.

Question by:czarbapora
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Assisted Solution

elite74 earned 1000 total points
ID: 39252143
Have you added that user to remote desktop users group? / have a remote access group to be accepted?

Accepted Solution

czarbapora earned 0 total points
ID: 39252153
The user has been member of RDP user group.
I figured it out, when the user is on RDP session login prompt, the shift key doesn't work. What a silly problem, I spend so much time troubleshooting and thought so deep.

Thank you anyway.

Expert Comment

ID: 39252181
haha dam you complex passwords ! ah thats good to know for future reference

Author Closing Comment

ID: 39265342
Thank you for your quick response.

Expert Comment

by:Chris Davis
ID: 39743438
Thanks must be an XP thing suddenly none of my XP clients could connect but Win7 could.

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update one table using parameters from another

Posted on 2013-10-23
Medium Priority
Last Modified: 2013-10-23
Hi: I have a delphi program where I want to, in English: "update all despatch records for customer X" where XXDESPATCH holds order records , GOORDERS holds order and customer records.
So far I have this code which updates a specific order in table XXDESPATCH:
ADOQuery1.SQL.Add('UPDATE xxdespatch  set despstatus= 1, scandate = :NOW where docno = :SELORD and despstatus = 0');
ADOQuery1.Parameters.ParamByName('NOW').Value := Now;
ADOQuery1.Parameters.ParamByName('SELORD').Value := (Edit5.Text);

Now I need to change edit5.text to a customer code(done!) but have the parameter SELORD pointing at field AccNo in table GOORDERS, joined to XXDESPATCH at docno.

Can anybody help me along here?
Question by:ClaytonGlass
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LVL 19

Accepted Solution

Bhavesh Shah earned 1000 total points
ID: 39593765

which field is common in both table?

UPDATE xxdespatch
set despstatus= 1, scandate = :NOW
from xxdespatch A, GOORDERS B
where <<a.commonfield>>=<<b.commonfield>>
and docno = :SELORD and despstatus = 0

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LVL 38

Expert Comment

by:Geert Gruwez
ID: 39593771
basically you only need the query ?

update xxdespatch
set despstatus = 1, scandata = :now
where despstatus = 0
  and docno in (select accno from goorders where customercode = :customercode)

this should update all the records for that customer

it's a little easier for us with some data of your tables
>> indicating what the source is and what the output should be

Author Closing Comment

ID: 39593810
Thank you very much! Give you the points as first to reply but thanks to any other submissions, too!

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by Mark Wills Attending one of Rob Farley's seminars the other day, I heard the phrase "The Accidental DBA" and fell in love with it. It got me thinking about the plight of the newcomer to SQL Server...  So if you are the accidental DBA, or, simp…
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connecting to the esxi web interface

Posted on 2014-01-18
Medium Priority
Last Modified: 2014-01-21
I am trying to access my ESXi 5.0 server via a web browser but, I can't connect. What would the correct port to access the server via a web browser.
Question by:jfholloway
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LVL 124

Assisted Solution

by:Andrew Hancock (VMware vExpert / EE MVE^2)
Andrew Hancock (VMware vExpert / EE MVE^2) earned 1000 total points
ID: 39791251
Port 80/443

e.g. http://<IP address of server>

see part 2 specifically...

see my EE Article, Step by Step Tutorial Instructions with Screenshots

Part 1: HOW TO: Install and Configure VMware vSphere Hypervisor 5.1 (ESXi 5.1)

Part 2: HOW TO: Connect to the VMware vSphere Hypervisor 5.1 (ESXi 5.1) using the vSphere Client
LVL 13

Accepted Solution

Abhilash earned 1000 total points
ID: 39791735
To access ESXi through web browser you will have to make sure that you are able to ping/reach the ESXi host from the machine you are trying to use the browser. Make sure that your ESXi and the machine are on same subnet or they are able to talk to each other.

The ports 80/443 must be open on the firewall of the machine from which you are trying to access ESXi.

I hope when you say web interface you are not  meaning web client. Web client is used only to access vcenter. NOt an individual ESXi host.

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Return Receipt Requested

Posted on 2016-10-25
Medium Priority
Last Modified: 2016-10-25
I am trying to do this in Gmail.

I found this:

Request a read receipt

    Compose a message as usual while using the desktop version of Gmail at mail.google.com.
    Click the More options icon in the compose window.
    Click Request read receipt.
    Send your message.

Read receipts - G Suite Administrator Help - Google Help

I tried to do that. My "More" options does not have that capability, see attached.

What can I do to enable it.

PS - EE REALLY needs a gmail category. It is used by I'd guess 100 million people.
Question by:Richard Korts
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1 Comment
LVL 84

Accepted Solution

Dave Baldwin earned 2000 total points
ID: 41859142
From that page:
Read receipts are available only for G Suite, Education, and Government customers. They are not available in personal Gmail accounts.
Also note that "Read receipts" are a Request that the user can deny, not something that you can force.  If you are trying to use it to keep track of your recipients, you will have only limited success.

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This is my first article on Expert Exchange on the Manual Method of Exporting Office 365 Mailboxes to PST format by using the eDiscovery mechanism of Office. Hope you will enjoy the article.
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Old 02-22-2002, 12:57 PM
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Join Date: Jan 2002
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Years of Piano

My 3 1/2 year old has been taking piano classes for almost a year. He plays little songs, read notes from the practice books while playing (C,D,E), and knows the notes by sight (short note, long note, rest, etc.). One day on the way to class, he informed me that he doesn't need to go to piano that day because he already knows how to play the piano.

To give him a sense of time-line and long-term committment, I suggested that he ask his piano teacher how long she has been playing the piano. So we arrived to class and he asked her how long she had been playing. She replied, "Almost 24 years." I asked my son how long he has been playing, and my son then replied, "20 years". He's only three and half years old!
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Old 02-23-2002, 09:18 AM
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Agency Information Collection Activities: Proposed Collection; Comment Request

Document Details

Information about this document as published in the Federal Register.

Published Document

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Start Preamble

In compliance with the requirement for the opportunity for public comment on proposed data collection projects (section 3506(c)(2)(A) of Title 44, United States Code, as amended by the Paperwork Reduction Act of 1995 (Pub. L. 104-13)), the Health Resources and Services Administration (HRSA) publishes periodic summaries of proposed projects being developed for submission to the Office of Management and Budget (OMB) under the Paperwork Reduction Act of 1995. To request more information on the proposed grant information collection activity or to obtain a copy of the data collection plan and draft instruments, call the HRSA Reports Clearance Officer at (301) 443-1129.

Comments are invited on: (a) Whether the proposed collection of information is necessary for proper performance of grantee functions including whether the information will have practical utility; (b) the accuracy of the burden estimate of the proposed collection of information; (c) ways to enhance the quality, utility and clarity of the information to be collected; and (d) ways to minimize the information collection burden on respondents, including the use of automated collection methods or other types of information technology. Start Printed Page 25836

Proposed Project: Ryan White Comprehensive AIDS Resources Emergency (CARE) Act Title I Grant Application Information Supplements: NEW

The CARE Act (codified under Title XXVI of the Public Health Service Act) was first enacted by Congress in 1990, and reauthorized in 1996 and 2000. It addresses the unmet health needs of persons living with HIV disease by funding primary health care and support services that enhance access to and retention in care. The CARE Act funded services reach over 571,000 individuals; after Medicaid and Medicare, it is the largest single source of Federal funding for HIV/AIDS care for low-income, uninsured, and underinsured Americans. Title I under the CARE Act provides emergency assistance to eligible metropolitan areas (EMAs) that have been most severely affected by the HIV epidemic, for the purpose of developing or enhancing a continuum of high quality, community-based care for low-income individuals and families. HRSA disburses approximately one-half of the Title I funds among 51 EMAs based on a congressionally-mandated formula. The remaining funds are available on a competitive basis to those same EMAs that demonstrate severe need for supplemental assistance to combat the HIV epidemic, and an ability to disburse and use supplemental resources in a manner that is immediately responsive to the local epidemic and cost effective.

The CARE Act requires local planning councils to establish Title I priorities and allocate funds, taking into account critical factors. These include the: size and demographics of the local HIV epidemic; demonstrated (or probable) cost effectiveness and outcome effectiveness of proposed strategies and interventions; priorities of the communities with HIV disease for whom the services are intended; coordination of HIV care services delivery with HIV prevention programs and programs for the prevention and treatment of substance abuse; availability of other governmental and nongovernmental resources; and capacity development needs resulting from disparities in the availability of treatment and services in underserved communities. Other planning council duties include developing a comprehensive plan for the delivery of services and evaluating the effectiveness of administrative mechanisms used by the grantee to disburse (contract) the funds locally.

The Title I Grant Application Information Supplements have been designed to collect information from EMAs in a consistent, standard way when they apply for new or competing continuation grant funds in a combined formula and supplemental grant application. This information is needed to determine that funds are being used as intended by the Congress and in compliance with CARE Act mandates, and that supplemental funds are awarded to grantees on the basis of objective criteria consistent with CARE Act requirements. This includes requirements that grantees demonstrate: (a) Severity of need for emergency assistance to combat the HIV epidemic, including the unmet needs of persons who know their HIV status but are not yet in care, (Information Supplements 1, 4 and 5); (b) a functioning planning council that is in conformance with statutory membership requirements and carrying out mandated duties and responsibilities, (Information Supplement 2); (c) an ability to use Title I grant resources in a manner that is immediately responsive to the local epidemic and cost effective, and in compliance with payer of last resort, maintenance of effort and related requirements, (Information Supplements 3 and 6); and (d) a comprehensive plan for the delivery of HIV/AIDS care services that is responsive to the local epidemic and unmet needs, (Information Supplements 7 and 8).

In addition, HRSA will use the collected information as a benchmark for monitoring grantee performance during the fiscal year; to identify individual and cross-cutting grantee technical assistance needs; and to detect emerging HIV/AIDS care services issues that may require changes in existing program policies or procedures.

The Title I Application Information Supplements will be transmitted by mail and electronically to all Title I EMAs and made available through the HRSA Web site. Applicants will submit the Information Supplements electronically along with Form PHS-5161-1 (Revised 7/00), SF-424 and the program narrative portion of their application, using the Grants Management electronic transmission mechanisms established by HRSA. The Information Supplements will include check box responses; fields for reporting numeric fiscal and epidemiological data; and text boxes for describing other required information. The Information Supplements will automatically generate totals when appropriate, and have other automated fields to minimize the time required to insert identifying information.

The Information Supplements will require Title I applicants/grantees to report local epidemiological information and some fiscal and programmatic data collected from Title I funded contractors (sub-grantees), which grantees have been collecting and reporting since FY 1995 or earlier. The approximate response burden for applicants/grantees is estimated as:

Estimated number of grantee respondentsEstimated responses per granteeTotal number of responsesHours per responseEstimated total hour burden

Send comments to Susan G. Queen, PhD, HRSA Reports Clearance Officer, Room 10-33, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857. Written comments should be received within 60 day of this notice.

Start Signature

Dated: May 10, 2005.

Tina M. Cheatham,

Director, Division of Policy Review and Coordination.

End Signature End Preamble

[FR Doc. 05-9677 Filed 5-13-05; 8:45 am]


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Union Pacific Railroad's Request for Positive Train Control Safety Plan Approval and System Certification

Document Details

Information about this document as published in the Federal Register.

Enhanced Content

Relevant information about this document from provides additional context. This information is not part of the official Federal Register document.

Published Document

This document has been published in the Federal Register. Use the PDF linked in the document sidebar for the official electronic format.

Start Preamble

Federal Railroad Administration (FRA), U.S. Department of Transportation (DOT).

Notice of availability and request for comments.

This document provides the public with notice that the Union Pacific Railroad (UP) submitted to FRA its Positive Train Control (PTC) Safety Plan (PTCSP) Version 1.0, dated June 1, 2016. UP requests that FRA approve its PTCSP and issue a PTC System Certification for UP's Interoperable Electronic Train Management System (I-ETMS).

FRA will consider communications received by October 3, 2016 before taking final action on the PTCSP. FRA will consider comments received after that date if practicable.

All communications concerning this proceeding should identify Docket Number FRA-2010-0061 and may be submitted by any of the following methods:

  • Web site: Follow the online instructions for submitting comments.
  • Fax: 202-493-2251.
  • Mail: Docket Operations Facility, U.S. Department of Transportation, 1200 New Jersey Avenue SE., W12-140, Washington, DC 20590.
  • Hand Delivery: 1200 New Jersey Avenue SE., Room W12-140, Washington, DC 20590, between 9 a.m. and 5 p.m., Monday through Friday, except Federal Holidays.
Start Further Info

Dr. Mark Hartong, Senior Scientific Technical Advisor, at (202) 493-1332,; or Mr. David Blackmore, Staff Director, Positive Train Control Division, at (312) 835-3903,

End Further Info End Preamble Start Supplemental Information

In its PTCSP, UP asserts that the I-ETMS system it is implementing is designed as a vital overlay PTC system as defined in 49 CFR 236.1015(e)(2). The PTCSP describes UP's I-ETMS implementation and the associated I-ETMS safety processes, safety analyses, and test, validation, and verification processes used during development of I-ETMS. The PTCSP also contains UP's operational and support requirements and procedures.

UP's PTCSP and the accompanying request for approval and system certification are available for review online at (Docket No. FRA-2010-0061) and in person at the U.S. Department of Transportation's (DOT) Docket Operations Facility, 1200 New Jersey Avenue SE., W12-140, Washington, DC 20590. The Docket Operations Facility is open from 9 a.m. to 5 p.m., Monday through Friday, except Federal Holidays.

Interested parties are invited to comment on the PTCSP by submitting written comments or data. See 49 CFR 236.1011(e). During its review of the PTCSP, FRA will consider any comments or data submitted. However, FRA may elect not to respond to any particular comment and, under 49 CFR 236.1009(d)(3), FRA maintains the authority to approve or disapprove the PTCSP at its sole discretion. FRA does not anticipate scheduling a public hearing regarding UP's PTCSP because the circumstances do not appear to warrant a hearing. If any interested party desires an opportunity for oral comment, the party should notify FRA in writing before the end of the comment period and specify the basis for his or her request.

Privacy Act Notice

Anyone can search the electronic form of any written communications and comments received into any of our dockets by the name of the individual submitting the comment (or signing the document, if submitted on behalf of an association, business, labor union, etc.). In accordance with 49 CFR 211.3, FRA solicits comments from the public to better inform its decisions. DOT posts these comments, without edit, including any personal information the commenter provides, to, as described in the system of records notice (DOT/ALL-14 FDMS), which you can review atprivacy. SeeprivacyNotice for the privacy notice of

Start Signature

Issued in Washington, DC, on August 29, 2016.

Patrick T. Warren,

Acting Associate Administrator for Railroad Safety, Chief Safety Officer.

End Signature End Supplemental Information

[FR Doc. 2016-21139 Filed 9-1-16; 8:45 am]


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Spencer Tracy, Burt Lancaster, Richard Widmark
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02 Mar, 2007 1 hr 50 mins U/A
Amitabh Bachchan, Jiah Khan, Aftab Shivdasani, Revathi, Rukhsar
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Assets of the top 10 hedge fund companies in the U.S. grew by more than a third in 2007, despite a combined loss of $24 billion, due to redemptions and faltering performance, the Financial Times writes.

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A South Florida man charged with running a $13.6 million scam involving nonexistent shares in companies including Facebook and Groupon was sentenced to 11 years in prison.

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The Spider-Man Complete Five Film Collection

  |  638 min
Rated TBC by the BBFC

Collection of five films in the 'Spider-Man' franchise. 'Spider-Man' (2002) stars Tobey Maguire as high school student Peter Parker who is bitten by a genetically-altered spider while on a visit to a scientific institute. Soon, he begins to experience unusual side effects such as increased strength, enhanced wall-climbing skills, and the ability to spin webs out of his wrists. Peter first attempts to make use of these skills to impress the girl next door Mary Jane Watson (Kirsten Dunst), but after his Uncle Ben (Cliff Robertson) is killed in an armed robbery, he is compelled to work for the greater good and reinvents himself as Spider-Man, the enemy of criminals everywhere. Meanwhile, arms manufacturer Norman Osborn (Willem Dafoe) transforms himself into the Green Goblin, begins to terrorise the city, and lays down the gauntlet to Spider-Man by abducting his beloved Mary Jane. 'Spider-Man 2' (2004) picks up the story two years on as the superhero struggles to keep his normal life as Peter Parker and his secret life as Spider-Man separate. When his love Mary Jane announces her engagement to another man, Spider-Man temporarily loses his powers as his emotions take over his body. After his best friend Harry Osborn (James Franco) takes a job working for scientist Otto Octavius (Alfred Molina), Peter discovers Octavius' plans to transform himself into a supervillain and take over the world. Can Spider-Man get his powers back in time to save the world? In 'Spider-Man 3' (2007), Peter's former friend Harry takes over his father's duties as the Green Goblin and sets his sights on revenge against the crime-fighting Spider-Man. Meanwhile, Flint Marko (Thomas Haden Church), the man who killed Peter's Uncle Ben, has been transformed into the shape-shifting Sandman and becomes another evil for Spider-Man to overcome. 'The Amazing Spider-Man' (2012) sees Andrew Garfield take on the role of the superhero. When Peter Parker was abandoned by his parents as a young boy, he was left to be raised by his Uncle Ben (Martin Sheen) and Aunt May (Sally Field). Always wondering about the circumstances that surrounded his parents' departure, Peter goes on a quest to find some answers. In 'The Amazing Spider-Man 2' (2014), Spider-Man's work-life balance is holding up extremely well as he spends his days as Peter Parker with his girlfriend Gwen (Emma Stone) and his nights leaping between New York's skyscrapers making the city a safer place. However, the emergence of Electro (Jamie Foxx), a figure with electromagnetic powers, poses Spider-Man's biggest challenge to date.


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Etherpad - Web-based real time collaborative editor

Etherpad lite is a really-real time collaborative editor spawned from the Hell fire of Etherpad. We're reusing the well tested Etherpad easysync library to make it really realtime. Etherpad Lite is based on node.js ergo is much lighter and more stable than the original Etherpad. Our hope is that this will encourage more users to use and install a realtime collaborative editor.

Gnome Office - office suite for GNOME

Gnome Office consist of bunch of application such as Word, Speadsheet, Presentation, Graphics and Database.

Calligra-suite - a continuation of KOffice

Calligra-suite is a continuation of KOffice. The new name reflects the wider value of the KOffice technology platform beyond just desktop office applications. Currently all applications except Calligra Words will be maintained by their respective KOffice developers.

KOffice - office suite for KDE

KOffice consists of several applications that offer a specialized interface for a certain task to a generic set of content components. Its office suite includes word processing, spreadsheets, presentations, graphics, databases, project planning.

OpenOffice - leading open-source office software suite

OpenOffice is the leading open-source office software suite for word processing, spreadsheets, presentations, graphics, databases and more. It is available in many languages and works on all common computers. It stores all your data in an international open standard format and can also read and write files from other common office software packages.

Apache POI - Java API To Access Microsoft Document File Formats

APIs for manipulating various file formats based upon Open Office XML (ECMA-376) and Microsoft's OLE 2 Compound Document formats using pure Java. Apache POI is your Java Excel, Word and PowerPoint solution. We have a complete API for porting other OOXML and OLE 2 Compound Document formats and welcome others to participate.

excelize - Golang library for reading and writing Microsoft Excel™ (XLSX) files.

Excelize is a library written in pure Golang and providing a set of functions that allow you to write to and read from XLSX files. Support reads and writes XLSX file generated by Microsoft Excel™ 2007 and later. Support save file without losing original charts of XLSX. This library needs Go version 1.8 or later. The full API docs can be seen using go's built-in documentation tool, or online at godoc.org.Here is a minimal example usage that will create XLSX file.

ClosedXML - The easy way to OpenXML

ClosedXML makes it easier for developers to create Excel 2007/2010 files. It provides a nice object oriented way to manipulate the files (similar to VBA) without dealing with the hassles of XML Documents. It can be used by any .NET language like C# and Visual Basic (VB).

Joeffice - Office Written in Java

Joeffice is the first open source office suite written in Java. Its features include Docking system. Visualize several documents in the same window, It can have a lot of documents open at the same time and easily switch from one to another. It works with Microsoft document formats (docx, xslx, pptx). It can get data through web services (RMI, SOAP, REST).

Feng Office - A Collaboration Platform and online office

Feng Office is a web based collaboration platform. It helps to manage your projects and business services, Collaborate with your team and your customers, Organize and share documents and files. Feng Office allows businesses to manage project tasks, billing, documents, communication with co-workers, customers and vendors, schedule meetings and events, and share every kind of electronic information.

LibreOffice - The Document foundation

LibreOffice is the free power-packed Open Source personal productivity suite for Windows, Macintosh and Linux. LibreOffice is the perfect choice for home users, businesses, government and other organizations. It's native file format is the ISO standardized ODF (Open Document Format), but LibreOffice can open and save Microsoft Word, PowerPoint and Excel files, as well as many other formats, bringing you the widest-available compatibility with other products.

NetOffice - MS Office in .NET

.NET wrapper assemblies for version independent using Microsoft Office, Excel, Word, Outlook, PowerPoint, Access, Project

DocX is a .NET library written in C# which allows a developer to manipulate Word 2007 files in an easy and intuitive way.

WebSync - Document editing tool similar to Google Drive or Microsoft Skydrive

WebSync is a document editing tool similar to Google Drive or Microsoft Skydrive. A limitation of Google Drive is not having a note taking application and a reason WebSync was created. WebSync makes up for this by providing a OneNote-esqe Notebook file type. It is a self hostable document editing tool. It has real time collaborative editing built in.

JODConverter - Automates document conversions using OpenOffice

JODConverter automates conversions between office document formats using OpenOffice.org or LibreOffice. Supported formats include OpenDocument, PDF, RTF, HTML, Word, Excel, PowerPoint, and Flash. It can be used as a Java library, a command line tool, or a web application.

NeoOffice - Office for Mac

NeoOffice is a full-featured set of office applications including word processing, spreadsheet, presentation and graphics programs for Mac OS X. It is created by forking OpenOffice and added Mac specific features to it. NeoOffice Mobile application is available for Android devices, iPhone, iPad, and iPod touch.

InfoPath Error Viewer

InfoPath Error Viewer provides an intuitive list to show all errors in the entire InfoPath form. You'll no longer have to find the validation errors by searching in individual view. It's developed as an InfoPath Add-in which works on both InfoPath 2007 and InfoPath 2010.

Confree for Outlook

Confree lets you create audio conferences from Claro / Telmex directly from Outlook.

MS Office Wrapper for .NET

.NET wrapper assemblies for working with MS Office. MS Office Primary Interop Assemblies is not required.


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Learner Placement Manager (Employment, Education) BLUL41435

Lowestoft, Suffolk
circa £24,000 per annum
28 Sep 2016
26 Oct 2016
Contract Type
Full Time

Learner Placement Manager (Employment, Education) BLUL41435
Norwich and Lowestoft
Salary circa £24,000 per annum

Permanent, full-time (40 hours per week)

Our client currently has an exciting opportunity for a Learner Placement Manager to join them Norwich and Lowestoft Centres.

This rewarding role provides the essential link between learners on the training programmes and local employers.  The opportunity seeks to tailor individual support and guidance to learners and to secure relevant and timely employability skills development through work placements. We recognise and specialises in supporting young people who may be disillusioned and disengaged from education and training; providing employability support on their programmes is critical to the learners’ programme and journey.

Working closely with Tutors and Learning Mentors you will provide ongoing pastoral care, information, advice and guidance as well as employability and learning support, working with learners to overcome barriers, helping them to identify, apply and secure work placements.  You will assess how the learner is progressing in the workplace with the employers’ involvement, reporting back to the team.

With previous experience gained working with 16 -18 year olds you’ll also be a strong communicator with a positive attitude able to motivate and engage young people. You will possess the IAG level 3 qualification, along with IOSH or a level 2 health and safety qualification to be able to verify the suitability of the working environment before learners begin their work placements. You’ll be a team player, highly organised with the ability to engage well with an existing bank of employers and new ones. You will need access to your own vehicle.

This is an opportunity to work for one of the biggest training providers in the country with a team who are passionate about developing and supporting young people to fulfil their potential. You’ll be working in an extremely rewarding culture that focuses on developing learners and staff and celebrating their successes.

As part of their safeguarding commitment you will be required to undertake an enhanced DBS check, provide evidence of identity and verification of employment history.

Our client is committed to safeguarding and promoting the welfare of children, young people and vulnerable adults. Everyone who applies for paid employment or volunteer activities with them will undertake a relevant check via the Disclosure and Barring Service and must provide evidence of their identity, two references and verification of their full employment history before they start work.

This is a Blue Octopus Recruitment Ltd vacancy who are operating as an employment agency. Once you have clicked to apply for this vacancy, we will then send you more information on the role including a copy of the application form via email.


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missing translation for 'onlineSavingsMsg'
Learn More

Thermo Scientific™ Sino Biological™ EFNB1 (EphrinB1) Recombinant Human Protein, His Tag

This recombinant protein was expressed from a DNA sequence encoding the extracellular domain (Met 1-Gly 232) of human EFNB1 (NP_004420.1) fused to a polyhistidine tag at the C-terminus

Brand:  Thermo Scientific™ 10894H08H25

Code : NEW

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 13426006

  • £139.00 / 25µg

Estimated Shipment
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For Research Use Only. Not for use in diagnostic procedures.

Ephrin-B1 (EFNB1), recombinant human protein is supplied as a lyophilized powder. It is suitable for use in protein studies such as protein structure analysis and protein-protein interactions. In general, recombinant proteins can also be used as an immunogen, as a protein standard, or in cell biology research applications.
  • Activity: Measured by its binding ability in a functional ELISA; immobilized recombinant human EFNB1 at 10μg/mL (100μL/well) can bind human EPHB6 with a linear range of 0.16-4μg/mL
  • Formulation: Lyophilized in PBS, pH 7.4, 5% Mannitol, 5% Trehalose, and 0.02% Tween 80
  • Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible

Shipping Condition: Room Temperature. This protein is manufactured by Sino Biological Inc.

Proteins, Expression, Isolation & Analysis; Enzyme & Protein Activity Assays; Protein Assay Controls, Reference Standards & Accessories
≥90% by SDS-PAGE
Store at -20° to -70°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.
EFNB1, RP3-496G1.1, CFND, CFNS, EFL3, EPLG2, Elk-L, LERK2
Kinases & Inhibitors
His Tag
5 x 5μg
Truncated/Recombinant/Cell Surface Protein/Ligand
<1 EU/μg
Assay Standard


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Club News

Well fought clean sheet - Davies

14 January 2014

First blank since November

Scott Davies was delighted to keep a long overdue clean sheet in the 1-0 win at Dagenham & Redbridge on Saturday.

The Town goalkeeper had not made a shutout since the Johnstone’s Paint Trophy victory over Carlisle United in November – 12 games ago.

However, after brave defending and a goal-line clearance from Mark Roberts at Victoria Road, Davies felt Fleetwood earned their reward after recent misfortune.

“It was important to keep our first clean sheet for a while,” he said. “We were deserving of one because the lads kept on fighting to the end.

“We all, as a unit, have been disappointed because we feel we haven’t kept the clean sheets we have deserved. There have been slight lapses of concentration here and there.

“I’ve felt a bit of pressure to keep one because it had been quite a while. Last season I had kept quite a lot at this point.

“It’s not just me who has kept a clean sheet, though. It’s those lads in front of me who have put a great shift in as well, so it’s dedicated to them.

“If we are hard to beat then we know we’ve got goals at the other end of the team.”

The 25-year-old admitted he had defender Roberts to thank, however, when Rhys Murphy’s goal-bound dink over Davies was cleared off the line by the Cod Army captain.

“It was superb from Mark to hook it away,” said Davies. “We do that every day in training.

“Roberts is a model professional and he never gave up on it. Whether it was in or not – I couldn’t see clearly - he saved the team on the day.”

The win moved Town up to 6th place in the Sky Bet League 2 table ahead of Saturday’s home game against Hartlepool United.

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My name is AJ, I'm male and 31 Year old. My Sign of Zodiac is aquarius. I live in Tallinn, Estonia. On Flirtic.com I've been registered for 16.11.2012 years.

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Was online 30.03.2017
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Education: High School - Completed
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I speak russian. My mother tongue is georgian.

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Марина Сидорчук

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My name is Марина Сидорчук, I'm female and 27 Years old. My Sign of Zodiac is scorpio. I live in Kiev, Ukraine. On Flirtic.com I've been registered for 19.11.2012 years.

If our iterests match, you can send me a message, make a gift or invite for a date.

I speak russian. My mother tongue is english.

Марина Сидорчук

05. November 1989 (27), Kiev, Ukraine
Was online 19.11.2012
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Alpha Natural Resources (NYSE:ANR) has bled red ink in eight of the last 10 quarters as it struggles through the coal industry's downturn. A revision of a key bank credit facility, however, shows that its lenders haven't given up on the company or the coal industry. And this is just one of several recent capital market transactions that show coal is getting the financial support it needs to survive.

Isn't it relaxing?
At a little over 40% of the capital structure, long-term debt wouldn't normally be considered a big overhang. However, in Alpha's case, it has lost money for seven consecutive quarters with the likelihood of more to come. That makes debt a much bigger issue.

The company's banking partners, though, have come to the table twice to rework its main credit facility. Increasing the facility in May and relaxing its covenants just a few days ago. The new change "eliminates the interest coverage ratio through the end of 2014." That gives Alpha plenty of breathing room as supply and demand balance out in the global thermal and metallurgical markets it serves. The covenants will slowly return to more normal levels by 2016 or so.

Not the only one
Alpha isn't the only company that's been helped out by its bankers. For example, Walter Energy (NASDAQOTH:WLTGQ) amended its credit facility in July, assuring that it remained on the right side of its debt covenants. Debt at Walter, however, is a more onerous 75% of the capital structure after what proved to be an overpriced merger. That's part of the reason why a dividend cut accompanied the credit facility update.

Walter has also tapped the debt markets to help shore up its financial position, issuing bonds due in 2019 to pay off a term loan. Alpha, for its part, tapped the capital markets by issuing some convertible debt to raise cash. Natural Resource Partners (NYSE:NRP) has also issued bonds, though in this case it was to permanently finance the acquisition of a soda ash miner. That move actually diversified the company further away from its reliance on coal royalties, but increased debt to around 80% of the partnership's capital structure.

Capital markets
That fact that coal companies, even those with high levels of leverage, have been able to work with banks and issue debt is a good sign. It means that they are getting the support they need in a tough market and that bankers believe these companies will, in the end, be strong enough to pay their debts.

In fact, some coal miners have even tapped the stock market. Rhino Resource Partners (NYSE:RNO) issued units in September to "repay borrowings outstanding under [a] revolving credit facility." That's common practice for partnerships, which often use credit facilities to fund expansion efforts. Natural Resource Partners basically did the same thing, issuing debt instead of units to pay off its credit facility. Rhino shareholders might have been better off had the partnership issued debt based on the currently high yield of its units, but it's still telling, in a good way, that Rhino was able to issue the units at all.

Don't count them out
Coal is clearly out of favor and needs a helping hand right now. Banks appear to be doing just that, and that will help the industry get to the other side of this downturn. In fact, even service providers like railroads are getting in on the act, with CSX (NASDAQ:CSX) reducing its prices to help support U.S. coal miners in the export market. Although that's a near-term hit for CSX, it helps maintain key customer relationships until the clouds clear. The same is true for the banks.

While it's easy to look at many of the above actions in a negative light, collectively they show the support being provided to U.S. coal. That should allow the industry, though maybe not every participant, enough breathing room to thrive again, or at least survive.

Reuben Brewer has positions in Natural Resource Partners and Rhino Resource Partners. The Motley Fool owns shares of CSX. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.


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Last week, Alnylam (Nasdaq: ALNY) announced that it had licensed its patents covering the use of RNAi to Shanghai GenePharma of China. If previous such deals are any guide, investors shouldn't be too impressed.

These RNAi licenses have considerable profit potential, since they can be doled out to multiple companies. Alnylam has granted licenses to around 20 companies that are developing RNAi therapeutics or selling reagents to scientists performing RNAi research.

Unfortunately, these licenses aren't yet bringing in big bucks. Alnylam didn't disclose the financial details of its latest deal, but last year, licenses brought in just $1.4 million (down from the 2006 amount, because Alnylam signed up fewer companies). For a company with $144 million in operating expenses last year, the licenses clearly aren't doing much to lower its cash burn.

At some point, Alnylam's intellectual property might be worth as much as PDL BioPharma's (Nasdaq: PDLI) patent on humanized monoclonal antibodies -- $221 million and growing -- but some of those RNAi therapeutics will have to hit it big before royalty income becomes a sizable portion of Alnylam's revenue.

Until then, the company will have to rely on its partners Roche, Novartis (NYSE: NVS), Biogen Idec (Nasdaq: BIIB), and the U.S. government to fund about a third of its operating expenses, with the rest being funded from its own cash. Fortunately, like most drug companies, Alnylam has a lot of it. It ended last year with more than $455 million and expects to burn through only $65 million this year.

I've been critical of the valuation that investors have put on RNAi technology. While I still think investors are taking a lot of risk, at least Alnylam has plenty of time to get the kinks worked out, even if the funding won't be coming from patent-licensing deals.

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Fool contributor Brian Orelli, Ph.D., doesn't own shares of any company mentioned in this article. Biogen is a pick of the Stock Advisor newsletter. The Fool has a disclosure policy.


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I have more than 35 years experience in the field of Trucking and Safety with expertise in professional driving issues, which include truck driver actions, reactions, responsibilities, qualifications, training, compliance, and safety. I have additional experience with motor carrier safety and regulatory compliance; federal motor carrier safety regulations, and have assisted transportation companies with safety issues and training.

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My consulting experience includes professional driving issues.

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My professional experience includes being a Truck and Safety Consultant, as well as having been a Commerical Driver.

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Awards & Affiliation

Arizona Trucking Association
National Safety Council

Partial List of Consulting Expert Witness Cases


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Foreword Reviews

Jasper Spring

Clarion Rating: 4 out of 5

This novel reaffirms that, although bad things happen, ultimately goodness shines through.

James T. Hughes’s Jasper Spring portrays the enduring strength of relationships, though a pallor of gloom also hangs over this story like the smoke from the forest fire that consumes much of the focus of the main characters.

Alice and Tucker are high school classmates in the rural West. Tucker inherits his family ranch, and he and Alice are married. The two begin to build their life together, aided by their trusted, talented, and indispensable border collie, Tommie––truly a principal character in the novel. Alice’s miscarriages are set in deep contrast to the life all around the couple, until, as if by divine intervention, a young boy, Ray, comes into their lives.

Tucker and Alice are shown to be the salt of the earth: hard working and honest. Their marriage is a practical choice, but they make a strong and resilient team. In contrast, Ray’s mother, April, is abusive, shiftless, and irresponsible. In Tucker’s eyes, April is but a child. She is on the periphery of Ray’s life and plays out that part on the edge of the story. She appears sporadically before disappearing altogether, and she remains an enigma throughout.

Ray is a character at a crossroads—aware of his mother’s shortcomings, and attracted to Tucker and Alice’s way of life. Ray risks his own safety while helping Alice and Tucker, a sign of his devotion to them.

These characters are, by and large, decent folks shown to try their best. They work hard, love and help each other, and contribute to the community. This is a story without a conclusive end, though. A dramatic fire is put out; there are details of a later resolution, but there no closure is provided.

A lengthy novel, Jasper Spring is almost an epic. Every nuance in the story is minutely examined, including pages on the way one should go about picking out a dog, from driving to the place were the breeder is to evaluating the various aspects of the tiny pups. The story moves slowly and makes use of a passive voice, a style that encourages pondering over meanings. The presentation of the book is greatly enhanced by line drawings interspersed throughout.

Jasper Spring is a story that honors traditional family values in a positive, feel-good way. It is a reaffirmation that, although bad things happen, ultimately goodness shines through.

Reviewed by John Senger

Disclosure: This article is not an endorsement, but a review. The author of this book provided free copies of the book and paid a small fee to have their book reviewed by a professional reviewer. Foreword Reviews and Clarion Reviews make no guarantee that the author will receive a positive review. Foreword Magazine, Inc. is disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255.

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Foreword Reviews

  • Foreword Review

Letters for the Woods

2005 INDIES Finalist
Finalist, Nature (Adult Nonfiction)

Life can quickly spin out of balance. The author, a Raleigh, North Carolina lawyer, was well aware of that possibility as he found himself torn between career demands and a desire to maintain a careful, manageable balance of life. Could he juggle a career, live a simple life, and be a good father?

He found a good way to do it by spending as much as possible of his free time with his family on wilderness canoe trips. These frequent trips gave him time to ruminate and instill an appreciation for nature in his children. And he shared those thoughts, gathered over the years, with readers in a journal, Paddle & Portage, which he published himself for eight years. Eventually that journal would gain a following of 10,000 readers and be managed by a freelance staff. At the request of faithful readers, journal entries have been collected in this volume of thirty-two essays that represent a personal narrative with some pearls of wisdom.

“It is said that no one on his deathbed ever wished for more time at the office,” he writes in “While Ye May.” The knowledge that time flies, gained early in Hurley’s life, made him realize that procrastinating and merely dreaming about paddling the nation’s waterways would never amount to anything more than reverie.

Hurley has been able to raise a family, have a law practice, and still thrive in the wilderness. He explains in some detail how he does it in “Traveling Light,” which focuses on materialism and the desire to “surround ourselves with a superabundance of material comforts.” By stepping away from the crowd, “we will often find we have wandered into the wilderness.” Following the writings of Henry David Thoreau, Hurley has found that his urgings of simplicity and minimalism and his intellectual rebellion during that era have been guideposts for him, as he reflects in “Law and Wilderness.”

The book’s photos are notable in that they convey scenes of nature and images of the author’s children enjoying nature. His sketches demonstrate that Hurley enjoys that relationship, too. One illustration, “Caroline at Cabbage Key,” depicts his daughter in sandals, climbing a palm tree. An uplifting photo, presumably taken by the author, shows his smiling wife hugging their two young children as they pose in front of their well-traveled but faithful Jeep with their canoe on the roof, as if to say, “Yes, you, too, can have it all if you work at it.”

This book may not increase the sales of canoes, but it could very well motivate young fathers to take their kids on more wilderness outings and prompt others to step back and rethink ways to bring more balance into their lives.

Reviewed by Karl Kunkel

Disclosure: This article is not an endorsement, but a review. The author of this book provided free copies of the book to have their book reviewed by a professional reviewer. No fee was paid by the author for this review. Foreword Reviews only recommends books that we love. Foreword Magazine, Inc. is disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255.

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Foreword Reviews

Throwaway Players

The Concussion Crisis, From Pee Wee Football to the NFL

In her book Throwaway Players: The Concussion Crisis, From Pee Wee Football to the NFL, former Tampa Bay Buccaneers President Gay Culverhouse reveals the dark side of football in America. Today’s fans see the six-figure contracts, the 20,000-square-foot mansions, and fast cars. They love the diving catches and bone shattering tackles, but are completely oblivious to the fact that the majority of retired players “are being fed to the lions of bankruptcy, arthritis, and dementia.” Culverhouse tells the fans what the National Football League does not want them to hear—the stark reality that for the majority of its existence, “the NFL didn’t care about their players once they were no longer on the field.”

Culverhouse, the founder and president of the nonprofit Gay Culverhouse Players’ Outreach Program, majored in special education in college, and is a researcher and diagnostician by training. Her book is based on her time spent as president of the Buccaneers, three years of medical research, excerpts from newspaper articles, interviews with leading neurologists, and the personal anecdotes of former players. Through this book, she seeks to raise awareness among fans and the league of what happens to NFL players once they leave the game. Her book is an essential read for athletes, coaches, parents, and football fans.

In Throwaway Players we learn that the average annual NFL salary is fewer than one million dollars, and that most of the money is not guaranteed. We also learn that the money vanishes as soon as a player is cut, retired, or leaves the team. We are informed that the average NFL career spans just four seasons, and that the majority of players are untrained for a second career. “Consider that a player has, in general, four years or less to make enough money for himself and his family to live on for the rest of his life,” writes Culverhouse.

From this perspective, Culverhouse hopes that fans, parents, and coaches will also become cognizant of the immense pressure placed on football players at all levels. From Pee Wee football to the pros, there is pressure to perform, to stay ahead of the competition, and to win. These pressures have led to players using steroids, keeping their concussions a secret, and playing through severe injuries.

In the end, the show goes on, but it’s the former players who pay the price for the mental and physical abuse suffered during their careers. These “throwaway players,” as Culverhouse calls them, have been exploited and then neglected by the league that brought them in and the fans that worshiped them.

Throwaway Players brings to light many of the most important issues the NFL is currently dealing with. The league is transforming before our very eyes as a result of people like Culverhouse. She wants the reader to know, however, that her main goal is not to kill the game, just to make it safer, and in turn, improve players’ health both during and after their careers. At times, Culverhouse lets her emotions get the best of her. However, as much as she is an idealist, she is also a realist—a realist who is well aware that football is, and always will be, a violent and dangerous sport.

Reviewed by Andrew Kipp

Disclosure: This article is not an endorsement, but a review. The author of this book provided free copies of the book to have their book reviewed by a professional reviewer. No fee was paid by the author for this review. Foreword Reviews only recommends books that we love. Foreword Magazine, Inc. is disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255.

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