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Free shipping on orders over $75! Code FREESHIP* Details

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Show off your savvy style with our home décor! Find beautiful pieces that will make everyone feel at home, at affordable prices.

Whether you’re going for classic or chic, make it happen with home accents and decor from Big Lots. Start with stunning window treatments - curtains, window hardware, blinds and shades. Then cozy up the floors with accent rugs, area rugs, and floor mats to keep everyone comfortable. Find the home accents that will make your décor stand out - framed mirrors in all shapes and sizes, statement wall art, picture frames and decorative pillows. Sweeten things up with our amazing assortment of scented candles, candle holders, wax burners and LED candles.

Personalize your space with quality home décor from Big Lots, at prices you’ll love!

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Campus plans on agenda

Big Spring Independent School District officials apparently will not accept an unacceptable rating for their schools.Student improvement plans for all campuses which received an “academically unacceptable” rating from the Texas Education Agency will highlight tonight’s meeting of the BSISD Board of Trustees, which begins at 5:15 p.m. in the high school board room.The school district and all but one campus was tagged with an “unacceptable” rating under TEA’s accountability system in August. Moss Elementary, which was rated “academically acceptable,” was the only campus to avoid the subpar designation.In the past several weeks, school officials have announced district-wide steps to improve BSISD’s academic standing, but tonight will zero in on improvement plans at the campus level. Proposals for the high school, junior high, Goliad Intermediate and Bauer, Washington, Marcy and Kentwood elementaries will be considered.In other business, trustees will:• Hold a public hearing on the district’s Financial Integrity Rating System of Texas (FIRST) rating.• Consider a resolution for the taxation of in-transit goods.• Consider personnel matters.• Discuss field turf for the football field.• Hear reports on the high school Bible class, delinquent tax collections and the district’s safety audit.


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Martha Horelica

Martha Horelica, 72, of Baytown, formerly of Stanton died Friday, Nov. 5, 2010, at her residence. Visitation with family will be Monday, Nov. 8, 2010, from 6 p.m. until 7 p.m. at Gilbreath Funeral Home in Stanton. Services will be held Tuesday, Nov. 9, 2010, at 10 a.m. at First Baptist Church in Stanton with Johnny Teague officiating. Interment to follow at Evergreen Cemetery in Stanton.


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Latest Reviews

Reviewed on 23rd Aug 2016

19 Reviews

Everything went well last night. Wilko was really good, everyone was happy with the song list. He was very friendly, and we would definitely consider booking him again. Kind regards

Reviewed on 23rd Aug 2016

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1 Review

Thank you very much for making our party very special. Your music added greatly to the atmosphere of the night and was enjoyed by all

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Sailing ~ Dinner ~ Dancing ~ Hat Party!

The Ultimate Madhatter Party has returned....!

That's right, get out your zany, dressy, goofy, big and funny hats! Because this is the event to show them off.

First off, the party will be taking place on "Seattle's Premier Party Boat" The Islander! We will sail on the open waters of Lake Union. The boat has 3 levels: there will be a DJ Dancing on the first level, lounging on the 2nd level and the open air on the top level.

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A delicious dinner will be served.
A skinless, boneless chicken breast marinated in a honey, apricot bourbon glaze and grilled to perfection, Penne pasta with a pesto cream sauce, a carribean mix of grilled vegetables and fruit, an assortment of freshly baked breads and of course our famous salad bar filled with fresh mixed greens and an array of toppers from which to choose.

And finally the Hats! All guests will be required to wear a hat to the party. Any shape, size or type: sombreros, ski caps, skull caps, bowlers, derbies, fedoras, berets, crowns, cowboy hats...the list goes on and on and on!
It can be as creative, elaborate and personal as you would like to make it. Just come with some sort of chapeau on your head.

Camera Renter™

CameraRenter will be at the Party!
Elegant, eco-friendly, and easy digital cameras will be distributed to guests for FREE. Everyone at the party can take as many pictures and videos as they’d like, and a few days later all the guests can view, download, print, and share all of the pictures and videos for FREE from www.CameraRenter.com! Finally, you’ll see the pictures everyone else takes at the party!

CameraRenter will take care of everything - you just take all the fun pictures and videos you want. Check-out their commercials What is CameraRenter and Elegant and Eco-Friendly Events for more info.

And yes, there will be prizes for the best hats!
The categories will be: Most Creative, Elaborate, Hilarious Most Clever. There will be Official Madhatter Hat Judges viewing all the hats during the festivities!

Tickets are $59.00. Purchase them here!

Party includes:
Delicious dinner, 3 hour boat cruise, DJ dancing, open bar, Hat Contest with Prizes!

Date: August 15, 2014, Friday
Boarding: 6:45 pm to 7:20 pm
Departing: 7:30 pm sharp
Returns: 10:30/10:45 pm (approx)


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Bike Sharing Program gains popularity.

This just in from Gothamist:

Bike sharing program…

read more here

A new bike sharing program on Governors Island has proven so popular that the DOT is considering ways to implement a similar program throughout the rest of the city.—–

The forum for urban design is offering a bike sharing program starting […]


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Old 10-06-09, 07:44 AM   #1
Legs; OK! Lungs; not!
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Chip in CF seat stay?

I had a pantsfull of bad luck last Sat AM on my way to a club ride. You can read the tragic details in the post referenced here.

Catastrophic Rear derailer failure!

The question is when the RD exploded something chipped the top of the seat stay about 3" above the dropout and chipped the CF. Can that/should that be inspected and repaired? The chip is more than paint.

If so, where do I find a shop that can repair it?

Thanks in advance.
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Take or send the bike to the company/dealer that sold/made it. They can answer your question correctly. All other answers are just opinions. Roger
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Disc 1: 1974 — On the Road with The Beach Boys (Director's Cut)

1974 Disc 1 coverNever before had cameras been allowed into the very private world of the touring Beach Boys quite like this — until now. This exclusive footage was shot using the very first portable video camera (called a Portapak) by UCLA graduate filmmaker and former Beach Boys musician Billy Hinsche, who takes you on a whirlwind romp through several days and nights of being up-close-and-personal with “you are there” scenes of life on the road with the group Rolling Stone magazine called “Band of the Year” for 1974.

Filmed on location during the April and May tours of 1974, you'll hear conversations among the band members (sometimes with the aid of subtitles so you don't miss a single word), be a part of the backstage shenanigans, listen in on plans for tour logistics and strategy, have a ringside seat at the hysterical madcap backgammon game called “The Match” (originally released as part of Billy's film The Road Well Traveled and unavailable for many years), and take a ride in the cockpit of the Beach Boys' private plane, where you will watch the takeoff sitting in the jump seat of the charter aircraft.

Through the eyes of the camera lens you will be transported right onto the live performance stage almost as if you were in the band. You're so close to the action that you will want to pick up a tambourine to play and sing along as the band glides through “The Trader,” “Long Promised Road” and “Marcella.”*

This rare historical black and white video footage is augmented by gorgeous color film and photos you have never seen before and is interspersed with interviews from 1974 band members and associates including Ricky Fataar (drums), Ed Carter (bass), Bobby Figueroa (percussion), Carli Muñoz (Hammond B-3), Billy Hinsche (piano), transitory synthesizer player Don Lewis, longtime tour manager Rick Nelson, and Holland album project sound engineer Steve Moffitt. Legendary record producer and Caribou Ranch owner Jim Guercio not only performs onstage with the band, but also shares his revealing insights and riveting stories as the group's manager and personal mentor to Dennis Wilson.

The Director's Cut is a slightly modified and expanded version of the originally released 1974 DVD that has newly discovered and restored vintage black & white Portapak video footage of the tour that extended into June of 1974; including a glimpse of the opening act, Kiki Dee, and vintage, never-before-seen, full color video footage from the 1989 BeaChago tour (Beach Boys & Chicago).

(Total running time is approximately 95 minutes.)

Disc 2: The Interviews

1974 Disc 2The Interviews is an entirely new movie unto itself. It is in full color with expanded interviews, anecdotes, and comments from Hinsche, Fataar, Carter, Figueroa, Muñoz, Guercio, and others; and a brand new lively, humorous, and heartfelt conversation with founding member Walter Parazaider of the musical group Chicago, who gives a detailed account of the spectacularly successful, record-breaking BeaChago tour of 1975, along with the aid of the original itineraries showing cities, venues, and dates. There is newly discovered and restored black & white Portapak video footage of the tour that extended into June of 1974, including a peek into the backstage scene at Nassau Coliseum in New York where old friends Elton John and Paul Simon stop by for a visit. You'll see rare photos and even more never-before-seen vivid color film of the era.

The film concludes with a visit inside the Hinsche family home in Beverly Hills, California, where Dennis Wilson is interviewed by his dear friend, Otto “Pop” Hinsche, at a party celebrating Billy's 23rd birthday in June of 1974. There are special appearances by both Celia “Mom” Hinsche and a young Michael Wilson (Dennis and Barbara's son) — and you're invited to the party!

(Total running time is approximately 75 minutes.)

If you think you've seen all the Beach Boys footage there is to see, you'll be delighted to know there is one more film to add to your wish list. This is a documentary that stands alone with its unique perspective, insight, and just plain fun — 1974 will rock you!

*Segments of each song are heard in full, live audio.

Note: A portion of the proceeds from the sale of this DVD will benefit the Carl Wilson Foundation.

Note: This is a 2 DVD box set.

Price: The price for 1974 — On the Road with The Beach Boys (Director's Cut) and The Interviews is only $35. Please include an additional $8 for US and Canada shipping & handling, or $10 for worldwide shipping & handling.

Send personal check, cashier's check, money order, or international money order (IMO) payable to: MFM Productions, 10624 S. Eastern Ave., Suite A-162, Henderson, NV 89052. Credit card purchases can be made using PayPal and sending payment to MFMPRODUCTIONS@AOL.COM

Warning: Send cash at your own risk! Allow 7-10 business days for delivery from the time your order is received.

“As close as it gets to as real as it was!”
Gerry Beckley, musician, co-founder of America

“Wow. Brings back such great memories of being on the road with Carl, Dennis, and Billy.”
Danny Seraphine, drummer, BeaChago (Beach Boys & Chicago), former member of Chicago

“JUST finished watching the DVD. What a pleasure. What an absolute service to the era, the Wilsons, and to THE BAND (finally!!!). Thanks for taking the time to do this for the people that still care.”
Howie Edelson, rock writer and producer, United Stations

“It’s hard to remember that the Beach Boys ever had to ‘prove’ themselves again but this footage shows why they became Rolling Stone's ‘Live Band of the Year’ in 1974. If you saw them perform in '73 -'74 you'll relive some very cool memories... if you didn't, you'll wish you were there! Fortunately, Hinsche's movie puts you onstage AND backstage with America's most important rock band ever. AMAZING footage.”
Brad Rosenberger, Warner/Chappell

“Billy Hinsche's 1974 is a voyeuristic joy to the Beach Boys' faithful fans. It's an eye-opening insight into the less-than-glamorous world of touring in a band, the joy of performing music, and the bonds that exist between friends and performers.”
Howard Kramer, Curatorial Director, Rock and Roll Hall of Fame and Museum

“This is the most unique rock and roll documentary footage I have EVER seen. It deserves Oscar consideration. I am a UCLA Film School graduate.”
Bruce Merrin, President, Merrin Public Relations

“Billy Hinsche's new film 1974 — On the Road with The Beach Boys is an absolute treasure. The 90-minute film is a unique window that reveals a pivotal time in the Beach Boys' history, and does that in a way that is not sensational at all. It's the matter of fact quality of this film that provides the viewer with incredible insight and also gives the film its charm. Hinsche takes us on a day by day journey through a piece of 1974, letting us inside band meetings, air travel, sound checks, hotel silliness, and live performances. You'll feel like you are there with them. You might want to grab an equipment case and haul it onto the stage for them before a concert, or pass the salt at the local diner as they eat lunch, or participate in a pillow fight at the hotel... no matter, you will definitely feel like a fly on the wall... seeing things in the casual, and unrehearsed way that they actually unfolded. In turn you will understand Mike, Al, Dennis, and Carl in a new way. You will gain an enhanced appreciation for how hard they worked and how many people it took to pull off what they were doing. There is one revelation after another, and Hinsche's tasteful editing style never gets in the way. New interview segments with Ed Carter, Jim Guercio, Stephen Moffitt, Ricky Fataar, and others only adds to the awesome learning experience.

“I came away with a bittersweet taste in my mouth after viewing this one-of-a kind film. Dennis was so healthy, seemingly happy, and no trace of the spiral that took him is evident in this film. Carl is gently in control, but still relaxed enough to be silly and engaging. Al pops in and out and always in a good-natured way. Mike seems guarded, resigned to his role, and is the least accessible Beach Boy in this footage. Although Brian does not appear, he is present through his music, the comments of the others, and in one hilarious scene where Dennis points to the sky and insists Brian's up there. Even though the camaraderie between the backing band and the principals is evident, there is a loneliness to the endless road that I especially felt watching this. Knowing that these guy's personal lives were forever impacted by leaving and coming back, and that they somehow had to wedge being iconic recording artists into their schedules and into their emotional framework is a taxing thing to consider. Seeing Carl and Dennis together here is a clear reminder that the best thing these people had wasn't fame or money or artistic gratification. The best thing they had was each other.

“Sometimes it all seems too good to be true, to be there with the Beach Boys in 1974, on the road, hanging out, having fun, making it happen, becoming the best band in the world... again. Someone needs to thank Billy for this film. Okay, I will. Thanks BH... this is truly a gift.”
Jon Stebbins, author

1974 2-disc DVD back coverDVD CREDITS

Director and Editor: Billy Hinsche
Executive Producer: Billy Hinsche
Co-Producer: Steve Latshaw

Filmed on location during the April, May, and June Beach Boys tours of 1974.

Featuring Mike Love, Carl Wilson, Dennis Wilson, Al Jardine, and Ricky Fataar.
With appearances by Billy Hinsche, Ed Carter, Carli Muñoz, Bobby Figueroa, Jim Guercio, and others.

Soundtrack includes live concert segments of:
“The Trader” (Carl Wilson – Jack Rieley)
“Long Promised Road” (Carl Wilson – Jack Rieley)
“Marcella” (Brian Wilson – Jack Rieley)

Soundtrack also includes John Hunter Phillips' recording of “Under A Beach Boy Moon” (Billy Hinsche – Desi Arnaz, Jr.) from his CD It's About Time.

Cover and Disc 1 photo: Ed Roach (roach-clips.com)
Back cover and Disc 2 photo “screen grab”: Billy Hinsche

1974 — On the Road with The Beach Boys
Copyright © 1974 and 2011, MFM PRODUCTIONS, INC.
All rights reserved.

Total running time Disc 1: 95 minutes (approx.)
Total running time Disc 2: 75 minutes (approx.)
Rating: PG
Standard/Region: NTSC Region 0
Widescreen format

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why do you need USED pads?

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low complexity of ingredients: Rum and coke ...

low complexity of ingredients:
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My pump failed shortly after using the Prestone bug wash. 3 days after I filled the reservoir because it was on sale, I tried using the wipers to clean off some bird droppings, there was no hum. ...
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Headlight condensation...

I've been having an issue with a LOT of condensation in both of my front turn signals. When I wash the car or it rains, the condensation will stick around for days. I'm assuming that the seals are bad or some such? Easy fix?

I'm not having any issues, so I hate to take the car in for just this, but it's annoying.

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If your MKII was still working, I'd say to wait until the red LED light on the MKII goes out before unplugging it.
Otherwise, just unplug the old, plug in the new MKIII (with the antenna cable) & you're good to go.

No special coding needed, nothing to "synch up".
It may take a bit for your new MKIII to see the new sattelites in your area unless the MKIII came from very close to where you live.

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BioRestorative Therapies Provides Company Updates with Shareholder Letter

JUPITER, Fla., Aug. 1, 2013 /PRNewswire/ -- BioRestorative Therapies, Inc. ("BRT" or the "Company") (OTC BB: BRTX), a life sciences company focused on stem cell-based therapeutics, today announced the issuance of a shareholder letter by Chief Executive Officer, Mark Weinreb, providing an update to shareholders on the Company's progress.

The shareholders were advised as follows:

Over the past 12 months, BRT's substantial investment in research and development has allowed the Company to continue executing on its growth strategy. There have been many developments, both operationally and scientifically, that have positioned the Company well as a growing stem cell biotechnology company with a specific focus on cellular treatments and therapies for certain medical applications.

Below are some of the Company's accomplishments and activities over the past 12 months:

  • In the latter part of 2012, BRT appointed Wayne A. Marasco, M.D., Ph.D. as Chairman of its Scientific Advisory Board. Dr. Marasco currently serves as an Associate Professor of Medicine at Harvard Medical School and Dana-Farber Cancer Institute. He is head of Marasco Labs, an accomplished research laboratory at Dana-Farber Cancer Institute known for discovery and therapeutic human monoclonal antibody development and for constructing and validating various human-mouse chimeric models in the area of cancer, infectious disease immunotherapy, regenerative medicine and tissue engineering. Dr. Marasco is a Principal Faculty Member of the Harvard Stem Cell Institute and has extensive experience in the field of stem cells.
  • Late last year, the Company announced that its common stock had begun trading on the OTC Bulletin Board. The company went through a very thorough and diligent review process by FINRA to attain the Bulletin Board listing. The Bulletin Board trading platform allows for more potential investors interested in purchasing the Company's stock. The Company is extremely pleased to provide investors increased visibility and transparency that this regulated quotation service provides.
  • In late November, BRT launched its new website available at The new site highlights the Company as an innovator and pioneer in the adult stem cell industry.  The Company's primary programs are highlighted in more detail on the website, along with rich imagery and information about therapies being developed.
  • At the start of 2013, the Company was invited to present at the Adipose Tissue Biology conference of the Keystone Symposia conference series. Chief Scientist and Vice President of Research and Development, Francisco Silva, presented the Company's research on "Human Metabolically Active Brown Adipose Tissue Derived Stem Cells." This research is a result of the scientific work the Company has been performing pursuant to its ThermoStem® Program, which is in the pre-clinical stage and which focuses on treatments for metabolic disorders (particularly focusing on Type 2 diabetes) and obesity and uses adult derived stem cells from brown adipose (fat) tissue stem cells.
  • On April 13th, Dr. Marasco spoke at the Second International Vatican Adult Stem Cell Conference: Regenerative Medicine -- A Fundamental Shift in Science and Culture. The event was held in Vatican City from April 11th to April 13th. Dr. Marasco spoke during the session entitled "Stem Cells, Cancer and Aging — A Search for Solutions." His talk was titled "What Questions Haven't Been Addressed with Respect to Stem Cells, Cancer and Aging?"
  • In April, the Company was invited to present at the 5th International Congress on Prediabetes and the Metabolic Syndrome in Vienna, Austria. Mr. Silva presented the Company's research on Human Metabolically Active Brown Adipose Tissue Derived Stem Cells. This research is a result of the scientific work the Company has been performing pursuant to its ThermoStem® Program.
  • The Company hired ProActive Capital in mid-April to help increase awareness of the Company among the investment community.  ProActive Capital is also helping to increase exposure through the use of social and digital media.
  • In mid April, the Company implemented a 1-for-50 reverse stock split which reduced its outstanding shares from 820,641,011 to 16,412,820. 94% of the shares voted were in favor of the proposal. The Company believes the reverse split will help attract a new base of shareholders as well as new institutional and retail support in the market.
  • In mid May, the Company signed an agreement with Dexterity, Inc., a product design and bioengineering firm, to further the development and production of its brtxDISC™ (Disc Implanted Stem Cells) stem cell therapy device.  This device plays an integral role in delivering stem cells for its proprietary bulging/herniated disc therapy.
  • In May, the Company once again presented its investment thesis at the Marcum MicroCap Conference.  To listen to the webcast, please visit The event hosted nearly 100 publicly traded companies with capitalizations under $500 million and attracted more than 1,000 people, including senior personnel from the presenting public companies, leading institutional investors, directors, bankers and service providers to the microcap marketplace.
  • At the end of May, the Company formally launched its "brtx-C Cosmetic" Program. The Company announced that it has developed a human cellular-derived extract that, per initial in vitro studies, when applied to skin cells, appears to cause a significant increase in collagen and fibronectin production (proteins that are essential for combating the aging of skin).  The Company plans to conduct additional in vitro studies to better understand the extract's mechanism of action and human cellular activity and is actively seeking collaborations with other parties to commercialize the product.
  • In mid June, financial personality and founder of NBT Equities Research, Tobin Smith, interviewed CEO Mark Weinreb with regard to the Company's hybrid business model and what it is currently doing that will help change the biotechnology landscape. Click here for the full interview:
  • In late June, the Company expanded its ThermoStem® Program by collecting 150 samples of human brown adipose tissue.  This strengthens its R & D platform for the development of treatments for metabolic disorders and obesity. For the past year, through strategic collaboration and internal efforts, the Company has grown a large library of human brown fat stem cells.  The compilation of a large number and variety of brown fat derived stem cells allows it to study and identify potential cell lines to be used in developing therapies.
  • In mid July, the Company was featured in the industry publication, "The Life Sciences Report." In the interview included in the report, CEO Mark Weinreb described how the Company's cell therapy process could possibly keep disc disease treatment out of the operating theater. Link to full interview:
  • Since 2011, the Company has raised approximately $9 million, which has enabled it to achieve clear milestones as it continues to build momentum on its growth strategy.

"Based on these accomplishments, we are excited for what lies ahead in the near and long term," states CEO Mark Weinreb.  "We continue to make speedy and efficient progress with our programs and look forward to further advancements regarding each of our exciting initiatives. I would like to thank all of our shareholders for their continued support.  We will continue to work diligently to further execute our growth plan so that BioRestorative Therapies will be able to mature into a prominent life sciences company."

About BioRestorative Therapies, Inc.

BioRestorative Therapies, Inc. ("BRT"),, develops medical procedures using cell and tissue protocols, primarily involving adult stem cells, designed for patients to undergo minimally invasive cellular-based treatments. BRT is developing the following scientific initiatives:

  • brtxDISC™ Program (Disc Implanted Stem Cells), a non-surgical treatment for bulging and herniated discs that addresses the gap between non-invasive and invasive back procedures. This research is still in the non-clinical, investigational stage.
  • ThermoStem® Program, a treatment for metabolic disorders (diabetes, heart disease, etc.) and obesity using brown fat stem cells. Initial non-clinical research indicates that increased amounts of brown fat in the body may be responsible for additional caloric burning as well as reduced glucose and lipid levels in the body.
  • brtx-C Cosmetic Program, based on the development of a human cellular extract that, per initial in vitro studies, when applied to human skin cells, appears to cause an increase in the production of collagen and fibronectin, which are proteins that are essential to combating the aging of skin. Potential cosmetic uses are being explored with third parties.

The Company also offers plant stem cell-based facial creams and beauty products under the Stem Pearls® brand at

This press release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events or results to differ materially from those projected in the forward-looking statements as a result of various factors and other risks, including those set forth in the Company's Form 10-K filed with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and the Company undertakes no obligation to update such statements.

Investor Contact:
Adam Holdsworth
ProActive Capital

Media Contact:
Sandra Lee
ProActive Capital

SOURCE BioRestorative Therapies, Inc.
Copyright©2012 PR Newswire.
All rights reserved

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Difficult Dialogues Initiative promotes diversity at MU, around country

COLUMBIA, Mo. As U.S. demographics continue to shift rapidly, the University of Missouri has made a commitment to valuing and promoting diverse points of view within the MU community and across the country. MU was one of 27 institutional recipients of $100,000 grants from the Ford Foundation Difficult Dialogues Initiative (DDI) in 2005, and one of only a small number of those original institutions to receive an additional $100,000 grant in 2008.

DDI activities focus on teaching and reinforcing knowledge, skills, and awareness of diversity issues in higher education related to race, gender, sexual orientation, religion and other forms of diversity. The program encourages difficult dialogues on important, controversial topics. Eryca Neville, a past DDI Faculty Fellow and newly appointed coordinator of the MU DDI campus program, believes the initiative is essential to democratic citizenship in an increasingly diverse society.

MU has used the Ford Foundation funding to promote constructive dialogue regarding academic freedom and cultural, religious, and intellectual pluralism at MU as well as at other institutions across the country. The university has now been awarded an additional $30,000 by one of the foundation's partner organizations, the International Institute for Education (IIE).

In 2009, the MU Difficult Dialogues Program hosted a summer institute, designed by program leaders at the University of Missouri in collaboration with the principal investigators of two other DDI institutional awardees at the University of Texas at Austin and the University of Alaska-Anchorage. Together, the schools provided participants with the foundational information, awareness and skills to develop DDI programs on their own campuses.

"This new $30,000 award from the IIE allows us to continue our efforts in expanding the reach of the DDI to six institutions that participated in our 2009 summer institute," said Roger L. Worthington, assistant deputy chancellor and chief diversity officer at MU. "Our new goal is to help other campuses around the country develop their own difficult dialogues program, and to establish a national movement for the advancement of difficult dialogues pedagogy in higher education."

"Facilitating difficult dialogues is an important tool to include various points of view across the wide range of perspectives in the wide variety of functions needed to sustain a university's function as well as a productive society as a whole," Neville said.

The University of Missouri has now received $230,000 in grants from the Ford Foundation and its partner organizations to advance the DDI. This includes the recent $30,000 grant that will be dispersed among several participating institutions including Texas Tech, Texas A&M, Oklahoma State, Baylor, the University of Kansas, and Iowa State.

Contact: Nathan Hurst
University of Missouri-Columbia

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Drug may prolong organ life in noncompliant kidney transplant patients

New research from the University of California, San Diego Department of Medicine, Division of Nephrology, shows that the anti-rejection drug sirolimus (brand name Rapamune) may help prolong the clinical benefit of transplanted kidneys and delay rejection, especially in patients who do not regularly take their prescribed medications (are "non-compliant"). While the transplant field has been highly successful at reducing rejection and graft loss in the first year, post-transplant, reducing risk for graft rejection in the long-term has proved more difficult.

The findings are being presented at the 2008 American Transplant Congress (ATC), in Toronto on Saturday, May 31, 2008, by Cheri Ye, M.D., who was mentored by Robert Steiner, M.D., professor of medicine, and Director of Transplant Nephrology.

"No one is perfect at taking medications," explained Steiner. "But missing doses of immunosuppression, or not taking full doses each day, will bring about gradual rejection of kidney transplants that is almost impossible to detect in its early stages. Long acting drugs like sirolimus may help with this problem."

A team of five UC San Diego investigators reported a careful assessment of immune function at "trough" levels (lowest daily levels) of the three most commonly used immunosuppressive drugs, using an assay (ImmuKnow/ Cylex) designed specifically to measure the degree of immunosuppression at any given time. Lower "mitogenic response" meant better immunosuppression and more protection from rejection. On average, the participants, 160 kidney transplant patients, were 6.4 years out from their transplant.

At these trough levels of drug in the blood stream, the assay demonstrated that sirolimus caused a significantly lower level of mitogenic response, and results appeared to be stable in individual patients over time.

"At least half of transplanted kidneys are lost through chronic graft rejection, usually within 10 years. When patients do not have those rejection problems, they can go for 20 to 30 years before kidney rejection or other serious problems. This is an especially important issue now because of our nationwide donor-organ shortage," said coauthor, David Perkins, M.D., Ph.D., professor of medicine & surgery, and Director of Research for Transplantation.

"This study was not commercially funded," added Steiner. "We just wanted to confirm what we suspected from experience in our transplant clinic, where we focus on compliance in many ways to help our patients keep their kidneys functioning well. We showed that when the daily dose is wearing off and another dose is due to be taken, patients taking sirolimus could be more protected against rejection than other commonly used agents."

The assay used is the only commercially available of its kind, and potentially valuable, but researchers emphasized that experience and understanding of it is limited.

"Our ATC abstract is a report of clinical experience, but real progress is often made at the level of basic science. My laboratory is studying this intensively at a basic level in several ways, including looking at the genetics associated with various responses to the assay," said Perkins.

The researchers believe that this new study may help develop tools to monitor patients in the long-term, and also contribute to a protocol for using sirolimus in less compliant patients. Steiner pointed out that, "The best results will occur if we prevent rejection, because once rejection is established the threat to graft survival is much greater, no matter what we do."

Contact: Kim Edwards
University of California - San Diego

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Federal government releases environmental, health, and safety research strategy for nanotechnology

The Federal Government today released a national strategy for ensuring that environmental, health, and safety research needs are fully identified and addressed in the fast-growing field of nanotechnology.

The 2011 NNI Environmental, Health, and Safety (EHS) Research Strategy provides an integrated research framework to guide all Federal agencies participating in the National Nanotechnology Initiative (NNI), the Federal Government's ten-year-old program for nurturing and coordinating the emerging science of nanotechnology. The research strategy will help the NNI leverage Federal resources and infrastructure to most efficiently produce research data that can be used to protect public health and the environment, while continuing to fuel innovations and capture the value of those innovations for the benefit of the American people.

Drafted to be consistent with the NNI Strategic Plan, which was released in February, the EHS Research Strategy identifies research priorities in order to best drive the responsible development of nanotechnology, one of four main goals of the NNI Strategic Plan. The EHS Research Strategy is grounded in the principles of risk assessment and product life cycle analysisrational approaches to protecting health and the environment that involve measures of risk at every stage of a product's development, from preliminary handling of raw materials to final disposal of finished products.

The strategy identifies six core categories of research that together can contribute to the responsible development of nanotechnology: (1) Nanomaterial Measurement Infrastructure, (2) Human Exposure Assessment, (3) Human Health, (4) Environment, (5) Risk Assessment and Risk Management, and (6) Informatics and Modeling. The strategy also aims to address the various ethical, legal, and societal implications of this emerging technology.

Notable elements of the 2011 NNI EHS Research Strategy include:

  • The critical role of informatics and predictive modeling in organizing the expanding nanotechnology EHS knowledge base;
  • Targeting and accelerating research through the prioritization of nanomaterials for research; the establishment of standardized measurements, terminology, and nomenclature; and the stratification of knowledge for different applications of risk assessment; and
  • Identification of best practices for the coordination and implementation of NNI interagency collaborations and industrial and international partnerships.

"The EHS Research Strategy provides guidance to all the Federal agencies that have been producing gold-standard scientific data for risk assessment and management, regulatory decision making, product use, research planning, and public outreach," said Dr. Sally Tinkle, NNI EHS Coordinator and Deputy Director of the National Nanotechnology Coordination Office (NNCO), which coordinates activities of the 25 agencies that participate in the NNI. "This continues a trend in this Administration of increasing support for nanotechnology-related EHS research, as exemplified by new funding in 2011 from the Food and Drug Administration and the Consumer Product Safety Commission and increased funding from both the Environmental Protection Agency and the National Institute of Occupational Safety and Health within the Centers for Disease Control and Prevention."

Invaluable contributions to the EHS Research Strategy were obtained through public engagement, including a series of workshops and an online portal to solicit feedback from stakeholders, including representatives from industry, academia, nongovernmental organizations, and the public. The strategy also incorporates recommendations received from external reviews of the 2008 NNI Nanotechnology-related EHS Research Strategy produced by the National Academies and a 2009 report from the President's Council of Advisors on Science and Technology.

To highlight the release of this strategy document, describe key features, and answers questions from stakeholders and the public, the NNI is hosting a webinar today, Thursday, October 20, from 12:00 noon-12:45 pm (EDT).

The webinar will begin with an overview of the strategy's development followed by comments from industrial, regulatory, and public health perspectives. Dr. John Howard, Nanotechnology Environmental and Health Implications (NEHI) Working Group Co-Chair, will serve as the moderator. NEHI is a Working Group of the Nanoscale Science, Engineering, and Technology (NSET) Subcommittee of the National Science and Technology Council (NSTC), a cabinet-level interagency council that addresses a wide range of issues in science and technology. Webinar panelists will include:

  • Dr. Treye Thomas, NEHI Working Group Co-Chair
  • Dr. Shaun Clancy, Evonik DeGussa Corporation
  • Dr. Janet Carter, Occupational Safety and Health Administration (OSHA)
  • Ms. Lynn Bergeson, Bergeson & Campbell

A question-and-answer period will follow the presentations. Questions may be submitted through the registration site until 12:45 pm Thursday, October 20. Registration is necessary in order to view the webinar online; please click here to register for the event.

Contact: Marlowe Epstein
National Nanotechnology Coordination Office

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My Medicare Matters(TM) Advises Evaluating Your Current Medicare Part D Plan During Open Enrollment

WASHINGTON, Nov. 6 /PRNewswire/ -- My Medicare Matters(TM), the community- based education program that has helped millions of seniors understand Medicare Prescription Drug Coverage, is encouraging people with Medicare to evaluate their current drug plan and decide whether to change plans during the Annual Open Enrollment Period.

The program has enhanced its award-winning Web site to help beneficiaries, their family members and caregivers more readily find the information they need to assess their Medicare Part D plan.

"Medicare plans change every year, and so do people's needs," said Wendy Zenker, executive director of the My Medicare Matters program. "People with Medicare should re-assess their plan to make sure it's still the right one and that it will continue to meet their needs for 2008."

"The web site is user-friendly, and a great tool for those who are looking for answers," added Zenker, who is also the National Council on Aging's vice president for Mobilization.

New to the Web site this year is a section called, "Review 2008 Choices," that was created especially for those who currently have a Medicare Part D plan. It focuses on why someone should consider changing plans, when it is appropriate to do so and how to pick a new plan.

The Web site continues to offer "Start with 7 Simple Steps" for those who are looking to join a plan for the first time. This section explains eligibility, how to evaluate current drug coverage, cost, and how to pick a plan. Both sections link to the Prescription Drug Plan Finder on and there is a helpful, downloadable instruction page that outlines how to use the Plan Finder tool.

"Like NCOA, we want to make sure seniors and their caregivers are equipped well to make decisions about Medicare Part D coverage. We believe that the resources available on will enable Medicare beneficiaries and their loved ones to have the best information at their fingertips during this Annual Enrollment Period," said Fusun Sevgen, Director of Medicare and Strategy Outreach, AstraZeneca, the sponsor of My Medicare Matters.

The Spanish language version of the My Medicare Matters web site has been updated as well and is available at

The 2008 Annual Enrollment Period begins November 15 and ends December 31, 2007. My Medicare Matters is encouraging Medicare beneficiaries to follow these four steps as they evaluate their plans:

1. Gather the list of medications you take, and the pharmacy, physicians

and other health care providers you prefer to use,

2. Review the information your current plan to mails you this fall; or

ask them how your plan will change next year,

3. Research the other plans that service your area and do some comparison

shopping to see if there is a plan that can cover your medicines at a

lower cost or with fewer restrictions, and

4. Make a plan decision before December 31, 2007. If you decide to

switch plans or are enrolling for the first time, do so by December 7

to ensure that you receive all your plan materials and can start

filling your prescriptions on January 1, 2008.

About My Medicare Matters

My Medicare Matters is an initiative sponsored by National Council on Aging, Access to Benefits Coalition and supported by AstraZeneca Pharmaceuticals LP; its goal is to help people with Medicare and their families better understand the Medicare prescription drug coverage so that they can assess their personal situation, understand their choices, compare plan options and make decisions they believe are right for their health and financial situation.

About NCOA

Founded in 1950, the National Council on Aging's mission to improve the lives of older Americans.

NCOA programs help older people remain healthy and independent, find jobs, increase access to benefits programs, and discover meaningful ways to continue contributing to society. A non-profit organization with a national network of more than 14,000 organizations and 3,200 members, NCOA is based in Washington, DC. For more information about NCOA, please visit

About AstraZeneca

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. It is one of the world's leading pharmaceutical companies with healthcare sales of $26.47 billion and leading positions in sales of gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and infection products. AstraZeneca is listed in the Dow Jones Sustainability Index (Global) as well as the FTSE4Good Index.

In the United States, AstraZeneca is a $12.44 billion healthcare business with more than 12,000 employees. For nearly three decades, AstraZeneca has offered drug assistance programs side by side with its medicines, and over the past five years, has provided over $3 billion in savings to more than 1 million patients throughout the U.S. and Puerto Rico. AstraZeneca has been named one of the "100 Best Companies for Working Mothers" by Working Mother magazine and is the only large pharmaceutical company named to FORTUNE magazine's 2007 list of "100 Best Companies to Work For." In 2006, for the fifth consecutive year, Science magazine named AstraZeneca a "Top Employer" on its ranking of the world's most respected biopharmaceutical employers.

SOURCE My Medicare Matters
Copyright©2007 PR Newswire.
All rights reserved

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(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
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(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
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text:
Navigation Links
Partnership of academic centers and community hospitals effective model for disseminating advances

CHICAGO -- A quality-control audit of community hospitals associated with Fox Chase Cancer Center in Philadelphia suggests that a partnership between a major academic cancer center, where most new treatment protocols are created, and community hospitals, where most care is provided, is a highly effective model for quickly and effectively disseminating advances in cancer treatment.

Fox Chase, an NCI-designated Comprehensive Cancer Center in Philadelphia, first established its network of 26 select hospitals in 1986. The Fox Chase Cancer Center Partners program is based on a strong foundation of cancer research and education in the community. A strong feature of the program is the access Partner hospitals have to the most advanced cancer treatment guidelines developed by Fox Chase and other member institutions of the National Comprehensive Cancer Network (NCCN).

"When research leads to significant changes in treatment, it can take years before community oncologists are able to fully adopt the new guidelines. What's unique about the Partners program is the timely translation of advances," said Margaret O'Grady, R.N., M.S.N., O.C.N., Director of Care Management and Clinical Operations of Fox Chase Cancer Center Partners. "The audit we conducted shows that our Partner physicians are highly compliant in incorporating recent advances in cancer treatment."

O'Grady and her team reviewed the medical charts of 124 patients at least 65 years or older treated for stage III colon cancer at Partner hospitals between 2003 and 2006. They checked for documentation compliance regarding recent advancements in the treatment of colon cancer according to treatment guidelines published by the NCCN. Specifically, the advances included increased awareness of obtaining a minimum of 12 lymph nodes at surgery, and the addition of oxaliplatin to adjuvant chemotherapy.

Compliance with NCCN guidelines for documentation was high: staging (98 percent), pathology report (91 percent), colonoscopy (75 percent and 58 percent reaching cecum), CEA (91 percent), CT abdomen/pelvis (93 percent), and chest imaging (100 percent). Activities of daily living were documented commonly (83 percent).

Nearly all patients (123/124) received adjuvant chemotherapy, although only 76 (61 percent) received oxaliplatin, a chemotherapeutic shown to extend the survival in this patient population.

"At first glance, this number looked low, but as we probed further, we found that all but 11 patients who didn't receive oxaliplatin had documented co-morbidities or other concerns that precluded them from receiving this treatment," explained O'Grady.

Thus, community medical oncologists were aware of data suggesting benefit of oxaliplatin, and documented reasoning for patients not receiving it. Whether elderly patients with stage III colon cancer are generally being undertreated requires further study.

The most common chemotherapy regimens administered were FOLFOX (54 percent), bolus 5-FU/LV (19 percent), and capecitabine (12 percent).

"Our audit also found a high rate of lymph node retrieval. This is critically important to medical oncology treatment planning," O'Grady said.

The records indicated that 74 percent of the patients had at least 12 lymph nodes retrieved. Nearly all patients (93 percent) received appropriate surveillance with history and physical exams at suggested intervals and routine CEA testing. Abdominal and pelvic surveillance CT was performed in 78 percent of patients.

"We found a drop off in compliance regarding the documentation of discussions between the doctor and patient about age and life expectancy in relation to adjuvant chemotherapy," said O'Grady. "This discussion is important and informs decision making."

Discussions about life expectancy and a patient's age were documented in only 49 percent of the cases.

"Further research should focus on targeted education efforts in these areas and assessment of their impact," O'Grady concluded.

Contact: Karen Mallet
Fox Chase Cancer Center

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(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
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text:
Navigation Links
Stryker Hip Recall Lawyers at Wright & Schulte LLC Investigating Claims, as Stryker Hip Implant Lawsuits in New Jersey Hit 80

Columbus, OH (PRWEB) March 10, 2013

Wright & Schulte LLC, an experienced personal injury law firm, reports that at least 80 Stryker hip lawsuits filed in the wake of the Stryker Rejuvenate and ABG II hip stem recall are pending in New Jersey’s Bergen County Superior Court. In January, the New Jersey Supreme Court granted a request by plaintiffs to consolidate all pending Stryker Rejuvenate and ABG II Modular-Neck Hip Replacement Stems lawsuits associated with the recall in a single proceeding in Bergen County.

Wright & Schulte LLC is offering free defective medical device lawsuit consultations to individuals who suffered serious complications due to the recalled Stryker Rejuvenate and ABG II Modular-Neck Hip Stems, including:

  •     Metallosis
  •     Tissue death
  •     Osteolysis
  •     Damage to bone and tissue
  •     Inflammation
  •     Premature failure of the implant
  •     Infection
  •     Loosening of implant
  •     Formation of pseudotumors

For more information on filing a Stryker hip replacement implant recall lawsuit, or to arrange for a free legal consultation, please visit

The Stryker hip implant recall was announced in July 2012, and involved some 20,000 metal components that had been sold since the Rejuvenate and ABG II hip came on the market in 2009. According to Stryker, Rejuvenate and ABG II hip stems are prone to fretting and corrosion at the modular neck junction. If this occurs, patients may experience pain, swelling, and adverse local tissue reactions. However, some Stryker hip recall patients have been found to have high levels of metal ions in their blood, even though they experienced no such symptoms.

According to a report by, plaintiffs with Stryker hip recall lawsuits pending in the New Jersey litigation allege the metal particles shed from malfunctioning Rejuvenate and ABGII hip stems caused them to experience muscle, nerve and bone damage. According to an attorney for some of the plaintiffs, many have undergone revision surgery to have their failing Stryker hip removed, while others will likely need revision surgery in the future. While Stryker’s marketing materials promised the Rejuvenate and ABG II components would last for 20 years, most of the plaintiffs experienced failure within just a few years of implantation.
[] is also reporting that Stryker is reimbursing patients for some costs related to the Rejuvenate and ABG II recall. However, because any information disclosed in the process of filing a claim with the company could be used in future legal proceedings, Wright & Schulte LLC is recommending that those affected should seek the advice of an attorney before they discuss reimbursement with Stryker.

About Wright & Schulte LLC
Wright & Schulte LLC, a leading personal injury firm, is dedicated to the belief that America’s legal system should work for the people. Every day, the attorneys of Wright Schulte LLC stand up for the rights of people who have been injured or wronged, and fight tirelessly to ensure that even the world’s most powerful corporations take responsibility for their actions. If you’re looking for a law firm that will guarantee the aggressive and personal representation you deserve, please do not hesitate to contact Wright & Schulte LLC today. Free Stryker Rejuvenate and ABG II Modular-Neck Hip Replacement Stems lawsuits case evaluations are available through, or call 1-888-365-2602.

Wright Schulte LLC
812 East National Road
Vandalia, Ohio 45377

Read the full story at

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

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3. US Drug Watchdog Now Offers Recipients Of A DePuy, Wright, Stryker, Biomet or Zimmer Metal on Metal Hip Implant The Names of the Best Law Firms If Their Hip Has Failed
4. US Drug Watchdog Now Urges All Zimmer, Stryker, Biomet, Wright and DePuy Metal Hip Implant Recipients to Get Blood Tests
5. Stryker Hip Recall Lawsuits Being Evaluated by Bernstein Liebhard LLP, Following Recall of Stryker Rejuvenate and ABG II Modular Neck Stems
6. US Drug Watchdog Now Urges All Zimmer Stryker, Biomet, Wright and DePuy All Metal Hip Implant Recipients to Get A Blood Test For A Failure-Don't Get Left Holding the Bag
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(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
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Breaking Medicine Technology:


text:
PDB Obsolete Entries

Philip Bourne bourne at hercules.sdsc.edu
Fri Dec 6 08:27:01 EST 1996

Obsolete Protein Data Bank (PDB) entries are now available as part of a
joint initiative between the San Diego Supercomputer Center (SDSC) and the
PDB.  Obsolete entries are those which have been replaced by newer versions
of the same structure or removed completely from the PDB distribution.
These entries are considered important for the following reasons:

1. To relate a structure description found in a paper to the corresponding
   set of coordinates even when a more recent set of coordinates are
2. For comparative analysis during software development. New software
   can not be compared to existing software, since the coordinate sets
   used to test the original software were not available for use with the
   new software.

It is important that these obsolete entries NOT be confused with
current entries. Hence they are kept in a separate database accessible
at http://www.sdsc.edu/PDBobsolete. There is a link between the PDB 3DB
database (http://www.pdb.bnl.gov/cgi-bin/pdbmain) and the obsolete

The obsolete database currently contains 291 structures. Structures may be
located by keywords or PDB ID. Once located structures can be displayed,
coordinates downloaded, and the chronology of an entry examined. Various
statistics on the content of the archive are also available.

The archive was developed by Helge Weissig and Phil Bourne.

More information about the Comp-bio mailing list


text:
[FUN] Dumbest lab experience?

Burkhard Hassel Burkhard.Hassel at t-online.de
Mon Jan 1 19:06:43 EST 2001

On 30 Dec 2000 00:30:51 GMT, kaghoram at unity.ncsu.edu (Karthik Aghoram)
>I always do the odour test before dipping my pipet tip in a bottle of
>TEMED;  Always works :-)!
And there was this question of a medical student:"Tips ? Is this
necessary when using a pipette?"
public final int ultimateMethod() {
	int level = 42;
	return level;

More information about the Methods mailing list


text:
Coli B and K-12

Keith Robison robison at
Fri Aug 26 07:49:47 EST 1994

Diane Stothard (dstothar at wrote:
: In article <1994Aug18.134716.6730 at>,
: Malin Gennady  <comalin at> wrote:
: >Does anybody know, what is the principal difference in
: >two wild strains of Escherichia coli, B and K-12 from metabolic,
: >genetical or physiologycal point of view.
: >Any information will be appreciated.

: In addition, does anyone know the amount of sequence divergence between these
: two strains based on the 16S rRNA gene, or any two strains of E. coli, for that
: matter? Thanks in advance!

There are a number of papers by Howard Ochman looking at the evolution
and phylogeny of the enterics.  I believe that 16S is far too conserved
for this purpose; proteins were used instead (i.e. the divergence in
16S between different E.coli strains is probably 0).

It would be a bit old, but one reference is the ASM E.coli/S.typhimurium
book, which has a review by Ochman and Allan Wilson.  You might also
look up papers by Dan Hartl (Ochman & Hartl did at least one paper
together on this subject).  I believe you can get to Hartl's complete
publication list via the Web at

Good luck!

Keith Robison
Harvard University
Department of Cellular and Developmental Biology
Department of Genetics / HHMI

robison at

More information about the Microbio mailing list


text:
Summer Course In Microbial Physiology

Chuck Daniels daniels.7 at
Wed Mar 6 09:50:42 EST 1996

                        Summer Course in Microbial Physiology
                              Department of Microbiology
                              The Ohio State University
               "Mechanisms of Microbial Adaptation"July 7-August 3, 1996
                                Sponsored by NSF and DOE

An intensive course intended for graduate students, postdoctoral fellows,
and industrial research scientists who desire advanced training in the
current techniques and research strategies of Microbial Physiology.  The
course will consist of  laboratory instruction and lectures by departmental
faculty and invited speakers.  Topics to be covered include: adaptive
responses during fermentations, biochemistry and regulation of
autotrophism, enzymology of methanogens, and regulation of carbon
metabolism.  Visit our world wide web page for more information: microbio.html.

Course Faculty: T. Conway, C. Daniels, T. Henkin, K. Kendrick, J. Krzycki,
J. Reeve, W. Strohl, and R. Tabita.

Invited Speakers: A. Demain, J. Frost, J. Golden, S. Golden, G. Gottschalk,
R. Gunsalus, R. Kolter, T. Krulwich, J. Pero, A. Sonenshein, R. Thauer, and
M. Thomm.

Financial aid: Room, board, and travel expenses will be provided for all
successful applicants.

To Apply: send a curriculum vitae, a statement of purpose, and two letters
of recommendation to: Dr. Charles J. Daniels, Department of Microbiology,
The Ohio State University, 484 West 12 Ave., Columbus, OH 43210.  Phone
(614) 292-2301; Fax (614) 292-8120; Email Daniels.7 at

                   APPLICATION DEADLINE: May 1, 1996

More information about the Microbio mailing list


text:
For further assistance, please email us
Throughout both BCIQ and the BioCentury Archives there are several icons used to make tasks easier.

The following examples show how to perform complex searches that BCIQ customers have found useful.
  • This icon can be found to the right of the Company list drop-down box. When a company list is selected in the drop-down box, you can click on this icon and a pop-up window will appear that displays the companies on the selected list. In this pop-up window, you can modify or delete the list.
  • This icon appears in many different filters. If you click on this icon it will automatically place a check mark in the boxes next to all of the selections listed under the icon. Click on the empty icon to remove all the check marks from the selections below the icon.
  • This icon can be found in the right hand corner of the company profile, the right hand corner when a chart is displayed and the right hand corner when a table is displayed. When you click on this icon the screen will expand and the upper and left toolbars will not be displayed. To get the upper and left toolbars back, just click on the icon .
  • To Show To Hide. These icons appear under several column headers in certain tables. Click on to display hidden text in a column where the text can be quite long. Click on to hide the text in that column.
  • This icon appears in the top right corner of the grey left hand tool bar that contains all the filters. You can click on these double arrows to shrink the left hand tool bar and expand the area where your table or chart is displayed.


text:
Group DNA

Group DNA adjusts the spacing of DNA sequences and adds numbering. You can specify the group size (the number of residues per group), as well as the number of residues per line. The output of this program can serve as a convenient reference for use with some of the other programs in the Sequence Manipulation Suite (such as DNA Pattern Find), since the numbering and spacing allows you to quickly locate specific residues.

Paste the raw or FASTA sequence into the text area below.

  • Use a group size of and show bases per line.


text:
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Any of several large carnivorous mammals of the family canidae usually hunting in packs, formerly common throughout the northern hemisphere but now chiefly restricted to the more unpopulated parts of its range.

Retrieved from "http://www.biology-online.org/bodict/index.php?title=Wolves&oldid=618"
First | Previous (Wolverine) | Next (Wolvish) | Last
Please contribute to this project, if you have more information about this term feel free to edit this page.


text:
Document Detail

Coronary vein balloon angioplasty for left ventricular pacemaker lead implantation.
MedLine Citation:
PMID:  12505227     Owner:  NLM     Status:  MEDLINE
OBJECTIVES: Retrospective analysis of five cases of coronary vein balloon angioplasty performed to allow insertion of left ventricular pacing leads. BACKGROUND: Coronary vein stenoses or an insufficient vessel caliber can preclude transvenous placement of coronary vein leads. METHODS: We compared our total patient population (n = 218), in whom we implanted coronary vein leads, to those five patients who required coronary vein angioplasty to allow lead placement. Standard over-the-wire coronary artery balloon angioplasty catheters were used to dilate the vessel to 2.5 mm (n = 3) or 3.5 mm (n = 2). RESULTS: Transvenous lead placement succeeds in >99% of patients. Four cases of target vein stenoses and one case of a vein of insufficient caliber were successfully treated by balloon angioplasty. There were no complications. CONCLUSIONS: Coronary vein angioplasty is an effective and safe technique to permit transvenous left ventricular pacing lead insertion in cases of target vein stenoses or insufficient target vein caliber.
Bert Hansky; Barbara Lamp; Kazutomo Minami; Johannes Heintze; Leon Krater; Dieter Horstkotte; Reiner Koerfer; Jürgen Vogt
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Publication Detail:
Type:  Journal Article
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  40     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2002 Dec
Date Detail:
Created Date:  2002-12-30     Completed Date:  2003-02-14     Revised Date:  2007-11-15
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States
Other Details:
Languages:  eng     Pagination:  2144-9     Citation Subset:  AIM; IM
Department of Thoracic and Cardiovascular Surgery, Bad Oeynhausen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angioplasty, Balloon*
Coronary Vessels*
Defibrillators, Implantable*
Heart Failure / therapy
Middle Aged
Pacemaker, Artificial*
Retrospective Studies
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interatrial septum pacing guided by three-dimensional intracardiac echocardiography.
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text:
Document Detail

Esthetic outcomes with porcelain-fused-to-ceramic and all-ceramic single-implant crowns: a randomized clinical trial.
MedLine Citation:
PMID:  21158931     Owner:  NLM     Status:  In-Process
OBJECTIVES: the aim of this randomized-controlled clinical trial was to compare the objective and subjective esthetic outcomes of two types of screwed-retained single-implant crowns.
MATERIALS AND METHODS: participants were randomly assigned to the test (all-ceramic) and control [porcelain-fused-to-ceramic (PFM)] groups and were seen under investigation at baseline (B), crown insertion (CI), 1-year follow-up (1Y), and 2-year follow-up (2Y). Objective parameters were assessed by an intra-oral digital photograph (1:1 ratio), a study cast, a standardized radiograph, periodontal/peri-implant measurements, and questionnaires were obtained for the subjective parameters. In addition, pink esthetic score (PES) and white esthetic score (WES) were calculated for both groups. For the subjective evaluation, a visual analogue scale (VAS) questionnaire was used to assess the level of patient satisfaction regarding the esthetic outcome. Then, nine expert clinicians visually inspected and assessed subjective evaluation at the professional level. Statistical analysis was used to compare between groups and investigational appointments.
RESULTS: twenty patients were included in the study, 10 allocated to the all-ceramic group and 10 to the PFM group. No statistically significant differences were observed for the objective measurements comparing the test and control groups. Minor chipping of the ceramic veneering material was observed in the two patients of control group. The mean difference for all groups comparing objective parameters revealed an increase of papilla height between time points. A slight recession (0.26 mm) of the peri-implant mucosal margin at the implant site was observed between 1Y and 2Y. Mean values for PES and WES were 13.9 and 13.1 for the PFM group and for the all-ceramic group, respectively. These values were not statistically significant. Implant crown volume, outline, translucency, and characterization showed major discrepancies with the contra-lateral natural teeth. As for subjective parameters, VAS patients' responses regarding their perceptions of the esthetic outcome showed no statistical differences between groups and clinicians' accuracy scores were 50% and 47% for PFM and all-ceramic crowns, respectively.
CONCLUSION: PFM and all-ceramic single-implant restorations may be indistinguishable from each other regarding the objective/subjective assessment of esthetic integration. The material chosen for fabricating an implant crown per se does not ensure an optimal esthetic outcome if other esthetic parameters are not present.
German O Gallucci; Linda Grütter; Rabah Nedir; Mark Bischof; Urs C Belser
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-24
Journal Detail:
Title:  Clinical oral implants research     Volume:  22     ISSN:  1600-0501     ISO Abbreviation:  Clin Oral Implants Res     Publication Date:  2011 Jan
Date Detail:
Created Date:  2010-12-16     Completed Date:  -     Revised Date:  -
Medline Journal Info:
Nlm Unique ID:  9105713     Medline TA:  Clin Oral Implants Res     Country:  Denmark
Other Details:
Languages:  eng     Pagination:  62-9     Citation Subset:  D
Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Harvard University, Boston, MA 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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