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Lionsgate UK has had a banner year led by The Hunger Games - but the distributor is also committed to backing British film. Wendy Mitchell talks to CEO Zygi Kamasa [pictured]

On one hand, there is Dickens and Shakespeare. On the other, Keith Lemon and Kelly Brook. Such is the diversity of Lionsgate UK’s releases.

“I like the mix of having all of them within our slate because it means you can take a different strategy with each one and hopefully you can tap into a slightly different audience every time,” says Lionsgate UK CEO Zygi Kamasa.

The distributor has had a huge year at the UK box office - hitting $106.1m (£66.2m) as of November 25, putting it sixth in the UK market, ahead of Paramount - led by The Hunger Games doing $38.1m (£23.8m). Yet some of its smaller UK films have become a top priority for the company.

“Two years ago, we really started getting heavily into British films. And we’ve released five major British films this year,” Kamasa says. Those were Ralph Fiennes’ Coriolanus, David Cronenberg’s A Dangerous Method, Lasse Hallstrom’s Salmon Fishing In The Yemen, Paul Angunawela’s Keith Lemon: The Film and Mike Newell’s Great Expectations, which opens Nov 30.

“Five is probably the most any one UK distributor has. That’s a mixture of co-productions and our productions,” he says.

Lionsgate has previously had one-off hits with UK films such as Harry Brown and The Bank Job. The company benefits from the financial might (and product pipeline) of the US-based Lionsgate but also the autonomy to run UK operations as a separate business. Lionsgate bought Redbus Film Distribution in an estimated $35m deal in 2005, rebranding it as Lionsgate UK in 2006. Redbus, founded by CEO Simon Franks and managing director Kamasa, had been around since 1998 with hits including Bend It Like Beckham.

Kamasa now says, boldly: “We want to be one of the strongest distributors to invest in production and investment acquisitions in the UK.” The company is off to a strong start with that plan, with all five of those 2012 UK films set to be profitable.

“We continue that investment this year and we have six British films for 2013, again making us arguably the biggest investor in British film outside of someone like BBC Films,” says Kamasa. “That is across acquisition and production.” He plans to invest in another six films for 2014.

The six titles for 2013 are: Jon S Baird’s Irvine Welsh adaptation Filth, starring James McAvoy; Hummingbird, a thriller directed by Eastern Promises writer Steven Knight and starring Jason Statham; Jonathan Teplitzky’s The Railway Man, starring Colin Firth and Nicole Kidman; Fiennes’ Dickens story The Invisible Woman; Pascal Chaumeil’s Nick Hornby adaptation A Long Way Down starring Toni Collette; and Richard Shepard’s crime story Dom Hemingway starring Jude Law.

Lionsgate’s role in each project varies: for The Railway Man, Lionsgate put up about 40% of the budget; Hummingbird was a straight acquisition.

Keith Lemon: The Film was financed solely by Lionsgate UK on a $5m budget. But usually the company will not fully finance projects. “The economics wouldn’t work for us. We can take the selective approach,” Kamasa says.

“We are not talking about Working Title Films… For us, by being strategic in what we invest and how much we invest, it reduces and mitigates a risk against what we feel we can make our money on.” Some productions, such as The Railway Man, will be handled by Patrick Wachsberger’s team at Lionsgate International (which recently completed its merger with Summit).

One bigger project in the pipeline is a $50m adaptation of UK TV crime action series The Professionals (which aired on ITV from 1977-83). “We hope to make that in the next 18 months or so, so that could potentially be an action franchise. That’s very much down to the package and the calibre of the director and cast we pull together.”

Cast was also crucial for Mike Newell’s Great Expectations. The Dickens adaptation has already played at festivals including Toronto and the BFI London Film Festival and is expected to be a big contender at the Baftas this year. It was a project that Lionsgate was involved with from an early stage, working on casting suggestions with producers Stephen Woolley and Elizabeth Karlsen.

“We know from a marketing perspective and a publicity perspective, if you put Ralph Fiennes and Helena Bonham Carter in a film, it makes a difference.” The cast also features hot rising talents Jeremy Irvine and Holliday Grainger.

The box-office boom

Lionsgate UK’s 2012 box-office takings are likely to hit $120.2m (£75m) by the end of the year, and The Hunger Games is not Lionsgate’s only success story. “At $82m (£51.2m), if you take out The Hunger Games, that’s still double what we did last year,” Kamasa notes.

The Expendables 2 was not a huge success in the UK, but the company is lined up for The Expendables 3 in 2014. “The Expendables 2 underperformed compared to the first one. I think there was a sort-of post-Olympics crush. We actually were one of the weaker-performing territories on that film, we were down about 30% on the first one. Although saying that, we were the strongest performing territory on the first one… I think with the third one we can re-energise it and outperform the second one”.

One success was acquisition title Magic Mike directed by Steven Soderbergh, which made a strong $13.3m at the UK box office; as well as Salmon Fishing In The Yemen hitting with adult audiences (at $9.9m in the UK).

“[Older audiences] want to go out to see a good movie once in a while because they’re bored of watching rubbish TV. And in research we did with them, we said, ‘Would you rather stay in and sit watching a TV show or a good movie?’ They all said the movie. And would you rather see a US or a British movie? It was 70% for a British movie… I think we tapped into that with Salmon Fishing; I think with Great Expectations we’ll do a similar thing.”

Looking ahead

For the past year Lionsgate UK has been working on Icon’s release pipeline of about 15 films, after Icon stopped doing its own distribution. Those titles include recent flop On The Road as well as forthcoming releases Only God Forgives and Postman Pat: The Movie.

With Icon out of distribution and an eOne-Momentum merger on the table, Kamasa says: “From six distributors two years ago now down to four in theory, it’s a big change in the industry. We’re always up against eOne and Momentum when acquiring movies, so it’s less competition for us.”

Having rights to a major franchise such as The Hunger Games is crucial to box office, not only in 2012 but beyond. The first film’s result was especially impressive because the book series was not as well known in the UK as it was in the US. “I think that’s only going to go up more and more,” says Kamasa.

The second film, The Hunger Games: Catching Fire, is due out in November 2013, with Mockingjay parts one and two coming out Nov 2014 and Nov 2015. “So there’s no doubt, both from the group perspective and from the UK’s perspective, that gives us a major blockbuster every year right down for the three years,” Kamasa says.

Other films on the 2013 release slate are Gerard Butler and Jessica Biel rom-com Playing For Keeps; Texas Chainsaw 3D, Arnold Schwarzenegger projects The Last Stand and Ten, White House-set action film Olympus Has Fallen starring Gerard Butler and Morgan Freeman; animated family film Postman Pat; The Big Wedding with an ensemble cast including Robert De Niro; Nicolas Winding Refn’s Only God Forgives with Ryan Gosling; Out Of The Furnace starring Christian Bale and Casey Affleck; The Iceman starring Michael Shannon; Lee Daniels’ The Paperboy; and Lovelace starring Amanda Seyfried.

In all, the 60-employee company has been handling about 12-15 theatrical releases per year, which will rise to about 18-20.

Keeping that UK pipeline busy will continue to be a priority. “We really want to see British film grow. Audiences actually are more supportive of British film than perhaps we distributors have let ourselves believe,” Kamasa says.


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The New York Film Critics Circle (NYFCC), the first of the US critics groups to announce their annual awards, has named Zero Dark Thirty Best Picture and its director Kathryn Bigelow Best Director.

The NYFCC gave its Best Screenplay award to Tony Kushner for Lincoln and its Best Foreign Film award to Amour.

David France’s How to Survive a Plague was voted Best First Film, Frankenweenie Best Animated Film and The Central Park Five Best Non-fiction Film (Documentary).

The Circle’s Best Actress award went to Rachel Weisz for The Deep Blue Sea and its Best Actor prize to Daniel Day-Lewis for Lincoln.

The Best Supporting Actress award went to Sally Field for Lincoln and the Best Supporting Actor prize went to Matthew McConaughey for Bernie and Magic Mike.

Greig Fraser was named Best Cinematographer for his work on Zero Dark Thirty.

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SDH Cancer
SDH Cancer

The National Institute of Health Pediatric & Wildtype GIST Clinic

My Pediatric and Adult Rare Tumor Network (MyPART) is a team of doctors, nurses, scientists, and other staff, working together to improve the lives of children, adolescents, and young adults with rare solid tumors.

Dr. Blakely's Clinic for SDH Deficient Gists

NCI believes there is an unmet need for comprehensive assessment by a multidisciplinary surgical team able to care for tumors in the stomach, liver, and peritoneal surface.  This team provides comprehensive care of adult patients with SDH-deficient GISTs of any stage. This includes care of associated tumors such as paragangliomas, as in the case of Carney Triad and Carney Stratakis syndrome.  Of note, the use of systemic treatment was not associated with survival. Given the lifelong predisposition to developing GISTs among patients with SDH mutations, it is not uncommon for patients to require multiple surgeries to remove areas of disease.

Prospective Study of Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis. Dr. Blakely primary investigator.  Currently recruiting patients for diagnosis, DNA testing, imaging, surgery and working in tandem with NIH's "MyPart's Family History Study."

NIH Pediatric and Wildtype GIST Clinic

The National Institute of Health in Bethesda, Maryland holds a Pediatric & Wildtype GIST Clinic.  Experts from all over the world attend to share information amongst themselves as well as educate patients, caregivers and parents on how this subset of GIST is unique. The patients who attend and who have attended this Clinic donate tissue samples and DNA (saliva) that stays on file for future research.   The Clinic is held annually, usually in June. All patients with a GIST diagnosis who are 18 years or younger, or those with a "wildtype" GIST diagnosis, are encouraged to apply.  International patients as well as US patients are accepted.   Contact and application information can be found at:

The PAWS - GIST Clinic

Inspired by the Pediatric and Wildtype GIST clinic at the National Institute of Health in America, the Pediatric, Adolescent, Wildtype, Syndromic GIST (PAWS-GIST) has been formed.  PAWS-GIST is a UK based alliance of medical specialists who serve patients in the UK and Europe. They hold an annual Clinic, usually in April, at Addenbrooke's Hospital, Cambridge, UK.  Contact and application information can be found at:

National Institute of Health Paraganglioma & Pheochromocytoma Clinic

Patients with known or suspected or pheochromocytomas may be seen at the NIH in Bethesda, Maryland. The NIH holds an Annual Pheo/PGL Clinic, by invitation.  Contact and application information can be found at:

Tumor Donations

Donation of tumor tissue is of upmost importance.  If you know you are having surgery for any SDH-related cancer or Wildtype GIST we would encourage you to reach out to the SDH-RA to pre-arrange to have your tumor tissue sent to researchers.   We can be reached at:

On December 9th, 2019, Dr. Liu presented a webcast on Pancreatic Neuroendocrine tumors.  He did an excellent job explaining neuroendocrine which applies to many patients with paras and pheos.

Q & A with Dr. Gottlieb and SDH cancer

What is SDH, How Is It Related to Cancer, and What Can Be Done About It?
Webinar by Dr. Eyal Gottlieb

Questions and Answers for the SDH Webinar (Answered by Dr. Eyal Gottlieb)
September 5th Podcast with Dr. Gottlieb and Sara Rothschild from Liferaft Group

Succinate Dehydrogenase in Cancer and Metabolism

Clinical trials for SDH-deficient GIST, Paragangliomas/Pheochromocytomas, and Renal Cell Carcinoma

Cancer Genetics Study at Huntsman, Utah
Especially looking for patients with a family history of SDHB tumors - Dr. Joshua Schiffman.

Fresh from surgery tumor donations especially desired.

Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions

The aims of this proposal are to: 1) to map gene(s) involved in pheochromocytoma, and 2) identify genotype-phenotype correlations in patients with pheochromocytoma/paraganglioma of various genetic origins.

Contact: Patricia L Dahia    210-567-4866

A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST, Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer

Follow this link to view the trial on the website:

Principal Investigator: John W Glod, M.D.
I think this trial was discontinued and had some stability but not long lasting

A Phase I Trial of the Glutaminase Inhibitor CB-839 on Solid Tumors

Follow this link to view the trial on  Active - not recruiting website:

Trial contact:  Trial Administrator

I think this trial has been discontinued without any long lasting results

A Phase I Trial of HIF-2a Transcription Factor Inhibitor PT2977 with Advanced Solid Tumors

Follow this link to view the trial on the clinicaltrialsgov

Trial contact:  Richard Kelley,  (972) 629-4088
This trial is for renal cell carcinoma and patients with the VHL mutation

Articles describing the rationale behind use of HIF-2a inhibitors:

New HIF2A inhibitors: implications for pheochromocytomas and paragangliomas
Rodrigo Almeida Toledo, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
 recently developed inhibitors of hypoxia-inducible factor 2-alpha (HIF2α). This Commentary is based on the recognition of similar molecular drivers in ccRCC and the endocrine neoplasias pheochromocytomas and paragangliomas (PPGLs), ultimately leading to stabilization of HIFs. HIF-stabilizing mutations have been detected in the von Hippel-Lindau (VHL) gene, as well as in other genes, such as succinate dehydrogenase (SDHx), fumarate hydratase (FH), and transcription elongation factor B subunit 1 (TCEB1), as well as the gene that encodes HIF2α itself: EPAS1HIF2α.
The now available therapeutic opportunity to successfully inhibit HIF2α pharmacologically with PT2385 and PT2399 will certainly spearhead a series of investigations in several types of cancers, including patients with SDHB-related metastatic PPGL for whom limited therapeutic options are currently available.

HIF-2alpha: Achilles' heel of pseudohypoxic subtype paraganglioma and other related conditions
Sri Harsha Tella, David Taïeb, Karel Pacak'
The main aim of this perspective is to address the possibility of HIF-2α antagonists in the management of tumours, beyond clear cell renal cell carcinoma, where the dysfunctional hypoxia-signalling pathway, especially HIF-2α, referred here as the Achilles' heel, plays a unique role in tumorigenesis and other disorders. These tumours or disorders include PGLs, somatostatinomas, hemangioblastomas, gastrointestinal stromal tumours, pituitary tumours, leiomyomas/leiomyosarcomas, polycythaemia and retinal abnormalities. We hope that HIF-2α antagonists are likely to emerge as a potential effective treatment of choice for HIF-2α–related tumours and disorders.

Hypoxia and hypoxia-inducible factors in neuroblastoma.
Påhlman S*, Mohlin, Lund University, Sweden.
Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.
In this review, we discuss these non-conventional actions of HIF-2α, its putative role as a therapeutic target and the constraints it carries, as well as the importance of HIF-2 activity in a vascularized setting, the so-called pseudo-hypoxic state.

A drug that inactivates HIF-2 activity by binding to the HIF-2 alpha subunit and thereby preventing its binding to the beta-subunit. The effect, seen in some renal cell carcinoma models, is the inhibition of HIF-2-driven gene transcription, which is thought to manifest an aggressive tumor phenotype.
Germline SDHB mutations will lead to an activated HIF-2 and in theory, an HIF-2 inhibitor can have positive effects on your tumor.*

The mutated HIF-2a in paraganglioma and pheochromocytoma results in stabilization of the protein so it is not degraded in oxygenated tissues and thus can complex with the beta subunit and form a functional transcription complex. This means that the factor can work under these "normal" conditions and promote a tumor phenotype and behaviour. In theory, a HIF2a inhibitor might have a positive effect on tumor cells that carry SDHB mutations, and that the HIF-2 inhibitor in conjunction with established chemotherapy might destroy HIF-2a positive stem cell pools.*

The following organizations are good sources to learn more

GIST Support International - Wildtype/SDH GIST -

SDH-deficient/Pediatric/Wildtype GIST Listserv Group -

The Liferaft Group -

Facebook - SDH Cancer Support Group - Gists, Pheos/Paras, RCC, Rare tumors

GIST Cancer Awareness Foundation -

GIST Cancer Research Fund -

Pediatric and Wildtype GIST Clinic at NIH -

PAWS-GIST (Paediatric Adolescent Wild-type & Syndromic GIST) UK - -

Pheo-Para Coalition -

Pheo-Para Alliance -

PheoParaTroopers -

ParaDifference Foundation -

Non-Profits Providing Financial Assistance to Cancer Patients

Cancer.Net explains Familial GIST -

SDH-Deficient GIST Researchers

GIST Support International, listing of GIST Specialists

Liferaft Group, listing of GIST Specialists

Dr. Andrew Blakely, GIST surgeon, NCI, MyPART, Bethesda, Maryland

Dr. Jason Sicklick, GIST surgeon, Moores Cancer Center, UCSD La Jolla, California

Dr. Joshua Schiffman, GIST, SDH, oncologist, researcher, Huntsman Cancer Institute, Utah

Dr. Michael Heinrich, GIST oncologist, Knight Cancer Institute, OHSU, Portland, Oregon

Dr. Kevin Billingsley, Surgeon, Yale, New Haven, Connecticut

Dr. Rodney Pommier, NET surgeon, Knight Cancer Institute, OHSU, Portland, Oregon

Dr. Jaydiro DelRivero Rare Tumors, NIH, Bethesda, Maryland

Dr. Karel Pacak, Senior Investigator Paraganglioma and Pheochromocytoma, NIH, Bethesda, Maryland

Dr. Constantine Stratakis, Senior Investigator, geneticist, NIH/NICDH, Bethesda, Maryland

Dr. Sosipatros Boikos, Wildtype GIST oncologist, Massey Center, Virginia Commonwealth University, Richmond, Virginia

Dr. Brian Van Tine, Oncologist, Siteman Cancer Center, Washington University, St. Louis, Missouri

Dr. JP Bayley, Paraganglioma Research Group, Department of Human Genetics,

Leiden University Medical Center, The Netherlands. Link is to SDHB Database of Known Germline Variances

Dr. Katherine Janeway, Pediatric Oncologist, Dana-Farber/Harvard, Boston, Massachusetts

Dr. Margaret Von Mehren, Wildtype GIST oncologist, Fox Chase Cancer Center, Philadelphia, Pennsylvania

Dr. Jonathan Trent, Wildtype GIST oncologist, Sylvester Comprehensive Cancer Center, Miami, Florida

Dr. Ron DeMatteo, GIST expert surgeon, Penn Medicine

Relevant Published Articles

NIH Pediatric Clinic Analysis of SDH deficient GIST patients - 2012, Dr. Su Young Kim

VIDEO - Analysis of the Pediatric Gist Clinic at NIH in 2012.  Nice clear explanation of SDH deficient GIST

Administrator's take: Dr. Su Young Kim, a friend to us who had the pleasure to meet him, giving a talk/analysis of Pediatric/SDH deficient GIST

Succinate dehydrogenase (SDH)-deﬁcient neoplasia
A.J. Gill, 2018, NSW
A detailed description of SDH mutations with their prevelence in Pheo/Paras, Gists, and other tumors

Surgical Management of Adolescents and Young Adults With Gastrointestinal Stromal Tumors:
A US Population-Based Analysis.

This study found that adolescent and young adult GIST patients are more likely to undergo surgical management than older adult patients. Operative management is associated with improved overall survival, including those with metastatic disease

Administrator's take: Surgery is still the best often for wildtype and SDH-Deficient GIST patients

Translating Genetic Data into Actionable Clinical Guidelines: Succinate Dehydrogenase Subunit A Variants of Unknown Significance in Gastrointestinal Stromal Tumors (2017). Scholar Archive. 3972 by Amber Bannon
A dissertation by Amber Bannon, OHSU.  I had the pleasure to meet Amber and this paper talks about how some gene mutations (SDHA) are more likely to produce tumors than other variances.  The key seems to be that the mutations proximity to the center of the gene which contains "Flavin" are more likely to be pathogenic.
Note, the paper is long and might take some time to load, it is worth reading.

Prognosis and management of adult wild type gastrointestinal stromal tumours (GISTs): A pooled analysis and review of literature

•Adults with WT GISTs have a similar molecular pathway to pediatric GISTs.
•Survival in both these subtypes is similar and more favourable compared to other GISTs.
Mean survival in adults was 15.7 years ± 0.78 and in children was 18.8 years ± 1.3 (p = 0.241). Median disease free survival in adults was 10 years while 5-year overall survival was 88%. Overall survival in adults with WT GISTs is favourable compared to other adult GIST subtypes likely reflects a common molecular pathway similar to pediatric GIST.

Administrator's take: Pediatric GIST and wildtype GIST patients have a longer survival rate than regular GIST

Diagnosis, Localization, Pathophysiology, and Molecular Biology of Pheochromocytoma and Paraganglioma
Karel Pacak, MD, PhD, DSc

What I found interesting:

The paper has a comparison of the Ga-Dotatate scan verse F-FDopa scan with superior clariety in the Ga-Dotatatate.

Then some things we know:
PPGLs with mutations in SDHB are the most aggressive forms of the disease, partly owing to their pseudo-hypoxic character, metabolic abnormalities, and elevated levels of reactive oxygen species (ROS).

Some tumor suppressor solutions they thought possible include two herbal:
Piperlongumine (PL), a natural product with cytotoxic properties

Topoisomerase I inhibitor, LMP-400

ATP5B antibody led to statistically significant inhibition of proliferation.

They were able to get a working mouse model using this technique:
NOD-scid gamma (NSG) mice xenografts of primary human PGLs took

Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations

Analysis of the Leiden Open Variation Database

Gists:  26 SDHA, 14 SDHB, 9 SDHC, 6 SDHD - Total SDH deficient Gist 55

Paras/Pheos:  7 SDHA, 211 SDHB, 42 SDHC, 141 SDHD - Total SDH deficient Para/Pheo 401

Familial PCC/PGL syndromes were initially thought to predispose only to PCCs and PGLs, but several tumors, including GISTs, RCCs, and PAs, have expanded the SDH-associated tumor spectrum. Extensive clinical variability can be expected, even among carriers of an identicalSDH germ-line mutation, with tumor phenotypes being only partially expressed, as in the Carney–Stratakis dyad.
These GISTs are characterized by unique clinicopathological features and biological properties: (i) female preponderance; (ii) gastric location (predilection for the distal stomach/antrum); (iii) common multifocality; (iv) a multinodular/plexiform growth pattern; (v) epithelioid cytomorphology, either pure or combined with a spindle-cell component; (vi) SDHA and/or SDHB immunonegativity; (vii) KIT (and DOG1) immunopositivity despite the lack of KIT/PDGFRA mutations; (viii) metastatic potential (often to lymph nodes); (ix) a relatively indolent clinical course, even in the presence of metastatic disease; and (x) insensitivity to imatinib

Hypoxia and 3-Nitropropionic Acid triggers to Tumors?

The SDHD gene was discovered by Dr. Baysal who was studying people in the Andes who got paragangliomas.  An email from him two weeks ago and he again advised me not live at in high altitudes NOR fly in airplanes.  Airplanes are known to have 80% of the oxygen that is on the ground.  SDHx patients have a compromised oxygen sensor.  Resource links to follow.

There are three breeds of dogs that by nature of the breed develop chronic hypoxia and they develop chemodectomas (the old word for paragangliomas and what is on my father's death certificate).  I just found a paper confirming this theory by two researchers in The Netherlands.  I contacted Dr. Bayley there who has been doing SDHB research for years and he said it was a colleague of his that wrote the paper.  I was hoping the research over the years on these breeds of dog would produce a chemo but the recommended procedure is surgery.

I then found a paper from 1974, the year my father died, that also said chronic hypoxias as in these dog breeds and people in the Andes causes paragangliomas!  Thus this information has been written about since 1974.

I think there are other means of hypoxia that could also eventually lead to disease such as sleep apnea, extreme sport activities, smog . . . And the wildfire smoke I have to live with for 5 weeks every summer that has air quality at "harzardous".

I also think a compromised system could be a trigger.  My own case I think comes from mold (house mold in my case) and research shows 3-NPs are "suicide" to the SDHB gene.  I had long exposure to environmental mold in a house I rented for my daughter for college as well as finding black mold inside the graphics studio I've worked in for 35 years.

Vet Comp Oncol. 2017 Jan 25. doi: 10.1111/vco.12291. [Epub ahead of print]
Pheochromocytomas and paragangliomas in humans and dogs.

Galac S1, Korpershoek E2.

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are described in several species. In humans and dogs they have many similarities: the excessive catecholamine release in hormonally active PCC causes similar clinical signs, the frequency of metastasis is similar, and they are histopathologically almost identical. Surgery is curative when PCC and PGL have not metastasized, while only palliative treatment is possible for patients with metastatic disease. Mutations in succinate dehydrogenase subunit B (SDHB) are associated with metastatic behaviour in human PCC/PGL and the same mutation has been described in dogs. The dog might therefore be a suitable model for study of the pathogenesis of metastatic PCC and PGL in humans. Further molecular studies of common tumourigenic pathways and comparative studies of histopathology of human and canine PCC and PGL are warranted.

What Baysal found was a mutation in the gene, named SDHD, that makes a protein eventually transported to the mitochondria— “the powerhouse and brains of the carotid bodies,”according to Baysal. The mutation causes the mitochondria to react as if they were in an oxygen-deprived environment, even though that is not the case. Consequently—as experienced by Andean Mountain dwellers—this tissue never stops working. The number of cells increases, and the increased mass eventually results in tumors.

Chemodectomas in Dogs: Epidemiologic Comparisons With Man2
Howard M. Hayes, Jr., D. V.M.  Joseph F. Fraumeni, M.D.

JNCI: Journal of the National Cancer Institute, Volume 52, Issue 5, 1 May 1974, Pages 1455–1458,

Fifty dogs with a confirmed diagnosis of chemodectoma were identified at 11 veterinary school clinic-hospitals. As in man, some evidence was found of genetic determinants: 2 brachycephalic breeds (Boston terriers and boxers) had a significantly greater risk compared to all other purebred dogs combined. An excessive risk was detected in males, though it was not statistically significant, and in older dogs. There was a significantly high frequency of 4 concurrent tumors (seminoma and interstitial-cell tumors of the testis, adenomatous thyroid neoplasms, and hemangiomas); but in man, with chemodectoma, the reported tendency to multiple primary tumors has been confined to the chemoreceptor system. The etiologic role of chronic hypoxia, suggested by the high incidence of carotid body tumors among Peruvians in the Andes, may be clarified by further studies of chemodectoma in brachycephalic breeds.

Altitude chart with amount of oxygen

Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis

Succinate is an important metabolite at the cross-road of several metabolic pathways, also involved in the formation and elimination of reactive oxygen species. However, it is becoming increasingly apparent that its realm extends to epigenetics, tumorigenesis, signal transduction, endo- and paracrine modulation and inflammation.

3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme*

The plant and fungal toxin 3-nitropropionic acid, an irreversible inactivator of succinate dehydrogenase, forms a covalent adduct with the side chain of Arg297.

The toxin 3-nitropropionic acid (3-NP) is produced by certain plants and fungi. It is a specific inhibitor of mitochondrial respiratory complex II. Fatalities after eating moldy sugarcane have been linked to 3-NP toxicity (,1, 2). Ruminants grazing in regions with 3-NP-producing plants acquire resistance because of reduction of the nitro group to an amine by ruminal bacteria.

Nitropropionic acid (3-NPA), an irreversible inhibitor of SDH activity (Huang et al., 2006).
beta-Nitropropionic acid (3-nitropropanoic acid, BPA, 3-NPA, C3H5NO4) is a mycotoxin, a potent mitochondrial inhibitor, toxic to humans. It is produced by a number of fungi, and found widely in food, in sugar cane, as well as Japanese fungally fermented staples miso, soy sauce, katsuobushi, and some traditional Chinese medicines.  Spices are susceptible substrate for growth of mycotoxigenic fungi and mycotoxin production. Red chilli, black pepper, and dry ginger were found to be the most contaminated spices.

Contents acculumlated by Cathy Freeman, SDHB Deficient Gist Patient

Searching to shed new light on this  incurable and often misdiagnosed cancer

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text:
I have received confirmation from the Dept. of Housing, Local Government & Heritage that hedge trimming on roads can be carried out all year round in the interest of public safety.
“I also received confirmation that hedge trimming can be carried out on farms in the ordinary course of agriculture and forestry as stated in the legislation which allows flexibility to farmers”.
“I have received many queries from farmers as their land is saturated from the prolonged period of heavy rainfall during the months of January and February. The most recent Met Éireann data for the period of January and February showed that the monthly rainfall totals were well above their Long-Term Average (LTA)”.
“The continuing high levels of rainfall has resulted in more flooding and poor conditions in many fields. This has severely impacted on the ability of farmers to carry out hedge management to fulfil their annual hedge management requirements”.
“The annual hedge maintenance work is vital so that sustainable stock-proof fencing can be maintained while preserving bio-diverse habitats in Irish hedgerows”.
“Given the extent of hedgerows that require management in Ireland, the working time calendar cannot be achieved in a practical and safe way this year to meet the needs of farmers, environmentalists and general road users due to the current weather constraints and therefore flexibility and understanding are required”.


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Pleurobranch acid secretions

May 6, 1999
From: Rhanor Gillette

Hi, Bill.
We in this lab greatly enjoy your sea-slug forum. Thank you for maintaining it. I was interested in yours and others' observations on Pleurobranchus forskalii. Is this the species that can grow up to a foot?

I wonder how easily available this species is, were I to find myself on the Barrier Reef in Oz? I work on pleurobranchs (Pleurobranchaea californica mostly), and have a comparative study I do when possible (rarely). I once looked at acid secretion and how it is integrated into the animals' behavior in Pleurobranchaea, Berthella, Berthellina and Pleurobranchus sp. -- J. Exp. Biol. 156, 335-347 (1991) -- the skin pH drops to 1.5 pretty fast. Never could bring myself to taste the animals, ought to, I guess but I'll put it off. Weirdly, taurine at 0.1-10 mM concentrations in SW triggers it in Pleurobranchaea, and I've been wondering if it does it for all the pleurobranchomorphs (there is some kind of selective receptor), but its hard to get any other species here in the american midwest.

Rhanor Gillette
University of Illinois at Urbana-Champaign

Gillette, R., 1999 (May 6) Pleurobranch acid secretions. [Message in] Sea Slug Forum. Australian Museum, Sydney. Available from

Dear Rhanor,
Glad you like the Forum. Pleurobranchus forskalii is usually found growing to about 10cm in length, but a few years ago in northern New Caledonia I was on a French Expedition where a couple of divers proudly returned with a couple of animals they had found in 12m which were 31cm long! So they definitely reach a foot in length. I must say I find animals growing that big a bit of a problem - too big to photograph, too big to dissect, too big to fit in any container etc. Those two, thanks to the insistence of Philippe Bouchet are now safely stored in a large polydrum in the bowels of the Paris Museum.

Concerning finding them if you are lucky enough to come to Oz. Well I have discussed this with a couple of experienced Great Barrier Reef collectors and their experiences are much the same as mine from East Africa. At times they can be very common (up to 10cm long) in shallow water back-reef - reef-flat regions, but there is no guaranteed time of year that you will find them. Sorry I can't be more deinite than that.

I would be interested in hearing of your work on Pleurobranchaea. Perhaps you could write an account for the Forum - even a review you've used for university report etc would be great. How do you work with these animals so far from the sea? Do you keep a breeding colony going or do you have to buy them from a commercial supplier?

Best wishes,
Bill Rudman.

Rudman, W.B., 1999 (May 6). Comment on Pleurobranch acid secretions by Rhanor Gillette. [Message in] Sea Slug Forum. Australian Museum, Sydney. Available from

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  18. Re: Notaspidean defensive secretions
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  19. Skin secretions in Pleurobranchus forskalii
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  20. Pleurobranchus forskalii, P. peroni
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Photo by Chason Gordon

Photo by Chason Gordon

If You Can’t Stand the Heat, Get Out of the Tropical Butterfly House

A life-and-death trip to the Pacific Science Center attraction.

For those seeking a respite from the soul-deadening cold, a trip to the Pacific Science Center’s Tropical Butterfly House may be in order, where you can instead complain about the suffocating heat. While it’s one of those attractions associated with entertaining your idiot relatives, the exhibit is actually worth a revisit for the plethora of diverse butterflies. You forget they exist, until you accidentally step on one and cry. (Editor’s note: No butterflies were actually killed in the course of reporting this story.)

There are several hundred in the flora-laden room, though it’s difficult to get an exact head count because the butterflies won’t stay still. Of note are Blue Moons (they have blue moons on them), Leopard Lacewings (they resemble leopards), and Banded Peacocks (you get the idea). Many are beautiful from a distance but creepy close up, like me. Chief among them are the Yellow-Edged Giant Owls, so named for the two large spots which resemble the judgmental eyes of an owl, otherwise known as the narcs of the forest.

All pass the time in the butterfly hoosegow by basking in the sun, chasing their rivals (called spiraling), and sipping flower nectar and overripe fruit juice with their giant proboscis. A pretty typical day for anyone, really. While the butterflies are allowed to chase each other, the house rules stipulate to not chase the butterflies (so unfair!). It’s understandable. The main task is walking around without accidentally killing things, a problem I have in many exhibits.

It’s unlikely you’ll inadvertently mush a butterfly, though some of them have it coming. The ones that fly low to the floor like they’re trying to avoid radar detection in World War II are taking their lives into their hands (or the butterfly equivalent of hands). Some even idiotically rest on the ground.

Perhaps it’s simply part of a butterfly’s life cycle. They begin as eggs, morph into caterpillars, form a pupa, turn into adult butterflies, and then are accidentally stepped on by a 10-year-old in a SpongeBob shirt. To be honest, I may have killed about 17 by mistake, but that was all due to a really big sneeze. (Editor’s note: See previous editor’s note). What’s tragic is the poor little creatures live for only one to two weeks anyway, and they probably spend their limited time on petty things, as humans do. One of them graciously let me get up close for a picture, until I realized he was dead. I put a mirror under his proboscis and got nothing.

This is why the Tropical Butterfly House receives weekly shipments of pupae from tropical countries like El Salvador, Costa Rica, and the Philippines. The show must go on. Some of the butterflies are go-getters and begin to emerge right away, while others can lazily take about a week to reach adulthood (fucking millennials). On the day I visited, the room was aflutter with Swallowtail butterflies, which can drink nectar while flying in place—though I can stand while sipping a beer, so it’s not that impressive.

What is impressive is having a butterfly land on you. You’ll know when it happens, because everyone will bow down and chant, “He is chosen!” The trouble is knowing what to do next. Proper etiquette requires that you walk slowly so as not to alarm the butterfly, and take it where it needs to go. When a Crimson Swallowtail landed on my shoulder, she said frantically, “Kiss me! Just kiss me, I don’t have time to explain.” So we kissed as two Yellow-Edged Giant Owls flew by, eyeing us suspiciously. Then she immediately took off. I didn’t even get her name.

Without a doubt the best part of the butterfly exhibit is leaving—not because you want to, but because you’re asked to spin around to check if any butterflies are trying to escape on your clothes. As the inspector approached, I was tempted to open my jacket like Neo in The Matrix and reveal a bounty of concealed butterflies. There actually was one on my shirt. “He came in with me,” I said.

As warm rooms go, the butterfly house is one of the best in town (what a sell). You’ve got saunas, laundromats, my grandmother’s house—really, there are very few options for getting out of the cold. If you’re looking to be in a smothering tropical climate, you might as well see some pretty flying things. Remember, they can remove the butterflies from your clothes, but they can’t take the memories (or the tiny, freshly laid eggs).

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Hiring Well-Qualified Locksmiths |

Hiring Well-Qualified Locksmiths

The life of locksmiths is revolving are revolving around three different sectors in which the residential sector commercial sector and automotive sector are mainly included. Locksmiths consider all these areas the most important as they put effect direct impact on the day-to-day life of humans and locksmith never want to take any chance and this is the reason that they mainly working at the front for saving millions and billions of lives from security-based complications. Locksmiths are active in handling general security-based issues along with emergency one and those who is good in tackling emergencies are generally named with the professional locksmiths. For them,an emergency is quite a simple thing and they are trained to act within that. Nowadays locksmiths are highly trained and qualified as they gain a lot of knowledge from various institutions offering locksmithing-based educations. Locksmith Bronx NY is the popular name that falls within the category of highly qualified locksmith services.

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What's In Blue

Posted Mon 20 May 2019

Possible Ukraine Briefing*

This afternoon (20 May), the Security Council may hold a meeting on Ukraine. Russia requested the meeting last Friday (17 May), to raise concerns with the recently enacted Ukrainian language law that it claims runs counter to the spirit of the Minsk agreements and resolution 2202.

At press time, the meeting is scheduled to take place this afternoon. However, some members, mainly the EU members and the US, appear to have questioned the need for an urgent meeting on this issue, which they do not perceive as connected to the Minsk agreements or related to international peace and security. These members seem to have advocated that the meeting be postponed, giving them more time to examine the issue and to make informed interventions. Should the push to postpone the meeting gain enough momentum among Council members, there is a possibility of a procedural vote on whether to hold the meeting today. (A procedural motion requires at least nine affirmative votes to pass, and the veto does not apply.)

Ukraine would most likely take part in the meeting under rule 37 of the provisional rules of procedure, which allows member states not on the Council to participate in meetings if their interests are “specially affected”. If the meeting goes ahead today, briefings would most likely be provided by Under-Secretary-General for Political and Peacebuilding Affairs Rosemary DiCarlo and OSCE High Commissioner on National Minorities Lamberto Zannier.

The Ukrainian parliament approved the Ukrainian language bill on 25 April, and it was signed into law by then-president Petro Poroshenko on 15 May. The law institutes Ukrainian as the official language of the country, requiring that it be used in the public sector.

Russian is spoken mainly in the eastern parts of the country, including the separatist-held areas of Lugansk and Donetsk. While Russia argues that the law is a prohibition of Russian and the languages of other ethnic groups in Ukraine, Ukraine emphasises that the law does not restrict the use of Russian or other languages in private and religious settings.

The timing of the meeting would coincide with the inauguration of the new president of Ukraine, Volodymyr Zelenskiy, who formally assumed the position earlier today. In the 21 April presidential elections, Zelenskiy won over then-President Poroshenko by a wide margin.

During his campaign, Zelenskiy focused mainly on the fight against corruption and ending the conflict in eastern Ukraine. A native Russian speaker, Zelenskiy has said that he would undertake a “careful analysis” of the law to make sure that “it respects the constitutional rights and interests” of all Ukrainians.

Post-script (20 May 2019): There was a procedural vote proposed by those objecting to holding the meeting. Five Council members (China, the Dominican Republic, Equatorial Guinea, Russia and South Africa) voted in favour of holding it , 6 (Belgium, France, Germany, Poland, the UK, and the US) voted against, and 4 (Côte d’Ivoire, Indonesia, Kuwait and Peru) abstained. The meeting was not held, as only 5 members supported convening it.


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Chapter 1 starts out with Will Tweedy recalling the summer of 1906, living in Cold Sassy when he was 14.

The story begins on July 5th, 1906, directly after the first 4th of July party since the Civil War. Rucker Blakeslee stops by Will's house for some Whiskey because would let him have any in the house.

Mattie Lou, Rucker's wife died 3 weeks earlier but he still goes to Will's house for the whiskey because it's what he has always done.

Rucker asks Will to find his Aunt, Loma and his Mother, Mary Willis. Will has to run to tell them that their father has arrived because they do not own a phone, just like many of the people in the town of Cold Sassy.

Will's family does not own a phone, indoor plumbing, and electricity because they can not afford it. Rucker does not own them either but its not because he cannot afford them, he just choses not to buy them.

Rucker tells them that he and his now dead wife have had a nice 36 years together, but he has now decided to marry Miss Love Simpson, who works in his store. Every one is shocked because his wife has been dead 3 weeks and he has already moved on.

In chapter 2, Rucker leaves for the store and every one is furious and is saying how miss Love is young enough to be his daughter and they consider her a "Yankee". Mary and Loma also worry about the town judging Rucker.


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Horn Hometown Tours: Saginaw Fire Department

LANSING, Mich. — State Sen. Ken Horn recently returned to Saginaw to continue his Hometown Tour series.

Horn spent the day with Station One of the Saginaw Fire Department learning how to use the equipment, doing training exercises with the crew, and exploring the daily duties of an on-duty firefighter. Station One houses 51 full-time firefighters with 13 on duty at all times. Before becoming a firefighter, trainees must complete 260 hours of training.

“This is the first job I’ve done where I was not only required to get dressed and ready within a certain time limit, but practiced doing so as well,” said Horn, R-Frankenmuth. “The firefighters’ gear is always lined up and ready to go in preparation for the next call. They have this down to a science and are ready in a matter of seconds. During the drills, I was still lacing up my gear and they were dressed and already heading toward the truck.”

After running some drills getting dressed, sliding down the pole from the loft, and other preparation needed in the event of a call, Horn took a brief tour of Station One’s vehicle inventory.

“Each vehicle has a specific purpose, from boats to the smaller fire engines,” Horn said. “What I found to be most impressive was the ladder truck. It has an on-board, 500-gallon water tank and a ladder capable of reaching 100 feet with a spray nozzle on the end. So, not only can they rescue someone trapped in a high-rise, they are also capable of spraying water from up there.”

After completing the introduction to the various equipment on site, the team then gathered in the ladder truck and departed for the training grounds. SFD has property within city limits that they use to conduct training exercises such as ladder use, practice working on pitched roofs and vehicle extractions. They also have a large tower they use to practice running hoses and bucket extractions with the ladder truck.

Once the training exercises on the tower were completed, Horn then moved to the opposite side of the property for the last leg of the tour: The Jaws of Life.

“I’d have to say my favorite part of this particular tour was the vehicle extractions,” Horn said. “Shattering glass with an axe and operating a piece of equipment that clipped and sheered through car doors like a tin can was certainly an exciting experience.”

Horn also noted how important it is for the community to know how extremely prepared the firefighters at SFD are.

“I think it’s great for the community to see this,” Horn said. “Firefighters are the first responders in many emergency situations, not just fires. They remove people from wrecked cars, people who are locked out of their house, people who are trapped inside something, and the list goes on. Giving the community an inside look as to what these folks do on a daily basis and the constant training and state of readiness that they are in should really inspire confidence among the community.

“I want to thank everyone involved in this visit for not only showing me a great time, but a valuable learning experience as well. A special thanks to Aileen Pettinger for organizing the visit, Battalion Chief Tom Raines for allowing the visit to happen, Matt Koch and Steve Orloff for assisting me with the drills and lastly, Captain James Champney for the incredible meal at the end of the tour.”

For video of this and previous tours, click here.

Horn’s Hometown Tours feature various communities in the 32nd District. If you are interested in having Horn visit, please contact his office at (517) 373-1760, toll-free at (855) 347-8032 or by email at [email protected].

Editor’s note: For a print-quality copy of each photograph, please visit www.SenatorKenHorn.com and click on “Photowire” under the Media Center tab.

PHOTO 1 CAPTION: State Sen. Ken Horn, R-Frankenmuth, and Lt. Aileen Pettinger (right) round up the gear Horn would be needing for the day’s training.

PHOTO 2 CAPTION: State Sen. Ken Horn, R-Frankenmuth, and Engineer Bob Weaver make their way to the top of the training tower in the department’s ladder truck.

PHOTO 3 CAPTION: State Sen. Ken Horn, R-Frankenmuth, stops for a photo with members of Saginaw Fire Department after training exercises with the Jaws of Life.


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Sons and Lovers

D.H. Lawrence

A classic tale of the clash of generations, Gertrude seeks escape from her brutish husband by doting on her sons William and Paul. But, soon suffocated and looking for his own escape, Paul turns to other women.
Genres: fiction, literature
68 issues
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text:
St. Edward School (SES) is a well-known and respected Catholic Elementary School in the Diocese of Nashville. Surrounded by some of Nashville’s oldest, yet fastest growing neighborhoods, our parish school holds a strong sense of community and tradition. This parish school with close ties to the church and community has developed a strong tradition, not just in the Diocese, but in the city of Nashville and surrounding areas as well. Families from 29 surrounding zip codes have chosen this hidden gem in the city for the education of their children.

A major strength of St. Edward School is its diverse population which represents the richness of Nashville. Students of all racial, ethnic and economic backgrounds gather daily to learn, play and pray together. Although our Catholic foundation is the purpose for the school, students of all faiths are invited to be part of our school community. A recent adjustment in tuition rates has equalized the tuition between Catholic and non-Catholic students. In addition, approximately one-fourth of our families qualify for financial assistance, making an education at St. Edward a practical reality for many families.

At SES, a dedicated teaching staff ensure that students learn in an atmosphere that balances academic rigor and individualized attention. Current initiatives include innovations in math and science along with the adoption of Catechesis of the Good Shepard, a hands-on approach to bring religion alive to our young students. An outstanding music program along with multiple after-school activities help provide a well-rounded education for our children.

All students at SES are welcomed into the family lovingly referred to as the “Saints”. From the front office to the classrooms, to the custodial and lunchroom staff and coaches on the field, all adults wrap their arms around our students to create an atmosphere of love and acceptance for all!


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Match Point | Movie Reviews | Seven Days | Vermont's Independent Voice

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Match Point

Movie Review

For people who've been around a while, and who know and love film, 2005 was a sort of bittersweet year. On one hand, Ingmar Bergman emerged from the shadows with Saraband, only to announce that it would be his final work. Now, boys and girls, this is a man who was regarded as a god back in those ancient days when cinema was considered an art form and not just something rappers and pop singers branch out into once their careers have taken off. History is measured by certain milestones, and the close of a career like Bergman's is such a landmark moment.

As Bergman receded back into the shadows, however, Woody Allen, a filmmaker famously influenced by the Swedish director, did the last thing his public expected. At 70 the director ended a streak of lightweight, minor releases and unveiled a philosophical drama as provocative and accomplished as any movie he has made. Match Point will leave many a moviegoer wistful for the days when motion pictures routinely contained things such as social conscience, psychological depth and -- are you sitting down? -- ideas as opposed to special effects.

An entire generation knows Allen chiefly as a result of the tabloid attention he received when he left Mia Farrow in 1992 for her adopted daughter, Soon-Yi Previn. This is the movie that will make clear to these youngsters why Woody Allen already had been considered a cultural icon for decades.

"The man who said, 'I'd rather be lucky than good' saw deeply into life," declares Jonathan Rhys-Meyers in the opening sequence. "People are afraid to face how great a part of life is dependent on luck. It's scary to think so much is out of one's control."

The character Rhys-Meyers plays is very lucky indeed. A former professional tennis player from a working-class Irish background, Chris Wilton has left the touring life behind and taken a job giving lessons at a private London club. It is his good fortune, almost as soon as he arrives, to be introduced to the son of a wealthy businessman and, after only a session or two, to be invited to join the fellow and his family at the opera and at their country estate. As Tom Hewett, Matthew Goode is a breezy, trusting, thoroughly likable chap who's always making cocktails and is likely to bring to mind a young Jeremy Irons. He's also betrothed to a sultry American played by Scarlett Johansson.

Rhys-Meyers insinuates himself into the family by pretending to be head-over-heels for his friend's sister (Emily Mortimer), a sweet but dullish young woman, while the truth is, he has an atomic case of the hots for Johansson. This condition persists after Rhys-Meyers and Mortimer tie the knot. In fact, it grows more serious. Eventually, they have an affair.

At this point, things seem to be going swimmingly for the socially ambitious young man. His father-in-law (Brian Cox) has set him up with a designer office, expense account and chauffeured Jag. The newlyweds have moved into an elegant loft the old man also thoughtfully subsidized. But, just when Wilton's luck appears to be running the hottest, it turns momentarily ice-cold. Though his wife is desperate to have a baby, guess which woman becomes pregnant.

What is Wilton to do? It doesn't take him long to conclude that it's not in his interest to alienate the loving, generous Hewetts. There's not a whole lot of soul to search in his case, so, faster than you can say A Place in the Sun, he sets in motion a chain of events worthy of Hitchcock. The only question, really, is whether luck will be on his side in the aftermath.

Match Point is Allen's deepest, darkest creation since 1989's Crimes and Misdemeanors and, in fact, explores a good deal of the same moral territory. In the earlier film, Martin Landau wrestled with the cosmic ramifications of arranging for a mistress' disposal. While the picture was greatly admired, Allen always felt he blew it. "I so regretted that I had my comic story in there," he told Entertainment Weekly in December. "I thought, my God, if I had made this film just about Marty and his predicament, it would have been so much better . . . I felt that it ratcheted down in substance instantly."

Sixteen years later, he has made the movie he wished he'd made back then. The writer-director is at the absolute top of his form. Though shot in London with a primarily British cast, the film feels more like a golden-era Woody Allen picture than any he's produced in years. Old recordings of Italian opera provide the soundtrack for the tragedy. Characters play things out against a backdrop of art museums and moviehouses. Human purpose, cosmic justice and love are sought but prove elusive. There's a moment in the movie when the young man considers his actions and, for an instant, hopes that he'll be caught. After all, he reflects, his apprehension would offer "some small measure of hope for the possibility of meaning."

With his 36th film, Allen offers hope for the possibility of meaning as well; the possibility that one of the most celebrated artists of our age hasn't finished his personal search quite yet, and that every now and then a movie with the old Allen touch might still make its way to the Cineplex.

Got something to say? Send a letter to the editor and we'll publish your feedback in print!

About The Author

Rick Kisonak

Rick Kisonak

Rick Kisonak is a film reviewer for Seven Days.

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Plan to let schools divide sexes / Bush proposal to pay for all-girl or all-boy classes

Photo of Heather Knight

The Bush administration announced plans Wednesday to allow public schools to educate boys and girls separately, a loosening of restrictions that could lead to the most dramatic shakeup of the co-ed system in more than 30 years.

The proposed changes would let school districts offer classes, grade levels or entire schools to just boys or girls. Federal regulations currently prohibit single-sex education in public schools except in sex-education classes and P.E. classes involving body contact.

Single-sex schools or classes would rely on voluntary enrollment and could be offered only if "opportunities for both sexes are substantially equal, " according to the U.S. Department of Education.

For example, a high school could offer an advanced placement physics class for girls only, providing that boys had the opportunity to enroll in a similar co-ed class. In addition, districts would be able to create single-sex schools with no restrictions; currently, they may only do so if a school for the opposite sex also is opened.

The proposed changes to Title IX regulations of the 1972 Federal Education Act will be published in a coming edition of the Federal Register, and a 45-day public-comment period will follow.

The proposal -- backed by a bipartisan group of female senators -- met with tepid reaction in the Bay Area.

Ann Melamed, president of the San Francisco Parent Teacher Association and the mother of a fifth-grade girl, said "separate but equal" rarely winds up fair.

"That's chilling!" she said. "I just sense that girls would lose out in this deal. ... I don't see a demand for this. You're creating a problem, and there isn't one."

Title IX prohibits sexual discrimination in schools that receive federal funding in order to assure that girls and boys get equal resources both in the classroom and on the athletic field. Administrations have interpreted this to mean that virtually identical opportunities must be provided to students of both sexes -- including being placed together in classrooms.

But as girls have narrowed the achievement gap -- even outpacing boys in some areas -- political opposition to single-sex education has dwindled. Democratic senators such as Hillary Clinton, D-N.Y., and Barbara Mikulski, D- Md., joined Republicans such as Kay Bailey Hutchison of Texas in calling for greater freedom of choice.

The Bush administration believes that loosening the regulations will give teachers, parents and kids a broader choice in education.

"This proposed regulation is yet another example of our efforts to provide maximum flexibility to help states and schools provide the best education possible for their students," said U.S. Secretary of Education Rod Paige.

The concept isn't new to San Francisco, which in the 1990s was one of a handful of California districts to participate in a two-year experiment with single-sex education. Under then-Gov. Pete Wilson, six pairs of all-boy and all-girl schools opened in 1996 and 1997 , one pair within San Francisco's Marina Middle School.

Most of the schools -- including those at Marina -- closed quickly because of poor planning, lack of state funding and lack of teacher training, according to a Ford Foundation study of the experiment.

San Francisco school board President Dan Kelly said few kids and parents were interested in the idea then, and he doubts many would be interested now.

"If there was community interest in it, we'd be open to discussion, but there hasn't been any kind of request or agitation or advocacy for that model, " he said.

San Francisco school board member Eric Mar expressed fear that girls would ultimately lose out under the changed regulations.

"I think this move is really turning back the clock to equal educational opportunities for girls," he said.

Single-sex education does have many backers -- including Anthony Cody, a teacher at Oakland's Bret Harte Middle School. Two years ago, he used a grant from the Chabot Space and Science Center to start a before-school science and technology class for girls. Despite having to arrive at school at 7:45 a.m., girls have clamored to get into the class, he said.

The girls have created digital movies and photo essays about their daily lives, boys and what would happen if aliens landed at their school. Cody has also taken them to education conferences where they've given speeches before crowds of adults.

Cody called the Bush plan "a great idea" and said boys need single-sex education just as much as girls do.

"Both girls and boys, especially at middle school, get caught up in social behavior related to impressing the other gender," he said. "Having a single-sex environment can allow them to focus on their own development ... without worrying so much about impressing the girls or impressing the boys."

Leaders of the National Coalition of Girls' Schools -- which represents 100 all-girls schools in the United States -- said they are glad the Bush administration recognizes the powerful effect of single-sex education.

"This is no experiment," the organization said in a statement. "Single- sex schooling is a time-tested means of helping today's children become tomorrow's leaders, and we applaud efforts to make this option available to all families."

Charlotte Fishman, an attorney with the San Francisco-based Equal Rights Advocates, said the Bush plan could be a boon for struggling girls -- or have a negative impact.

"The devil is in the details. Single-sex education can be a benefit for girls in certain circumstances, but relaxing the rules can also be a way to offer fewer resources for girls. It really depends on how the regulations are interpreted," she said. "You just don't know what's going to happen."


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Sonoma County

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March 11, 2019
The ultimate guide to wine in Sonoma County

Guide to Wineries and Wine Events in Sonoma County

The enticing delights of wine country are just an hour’s drive north of San Francisco in lush and bountiful Sonoma County. Home to 60,000 acres of vineyards, more than 425 wineries, and 17 distinct American Viticultural Areas (known as AVAs or appellations), Sonoma County makes the perfect wine country addition to your visit to San Francisco. Whether you’re a relative beginner or an experienced wine enthusiast, there are many options to choose from when creating your ideal wine adventure in Sonoma County. Here’s a quick overview of a few of the possibilities.

Tasting Underground

Caves provide ideal chilly-humid conditions for storing wine barrels during the aging process. They also make a great place to tour and taste, and Sonoma County offers some of the best wine caves around.

Free cave tours are offered twice daily at Alexander Valley Vineyards, where a 25,000-square-foot cavern carved deep into the hillside holds 10,000 barrels. The recently restored champagne-style cellars at Buena Vista Winery, California’s oldest commercial winery, actually have Historic Landmark status. And the deep, dark volcanic wine caves are a centerpiece at Hans Fahden Vineyards and Winery. Of course, these are just a few of the many distinctive Sonoma County wine caves and cellars where you can tour and taste.

Sipping at the Top

If you prefer a gorgeous view while you sip, Sonoma County has many amazing choices. Take a personal vineyard and winery tour (reservations required) at BobDog Wines & Sky Pine Vineyards. Perched 2,000 feet above the Alexander Valley, this is Sonoma County’s highest winery, with stunning views. Known for “the most beautiful view in Sonoma County,” Paradise Ridge Winery hosts its popular Wines & Sunsets in Paradise on Wednesday evenings, mid-May to October. And the hilltop chateau tasting room at Chalk Hill Estate Vineyards & Winery offers stunning views over a natural amphitheater of mountains along the eastern edge of the Russian River Valley. These are just two examples of the many Sonoma County wineries with amazing views.

Delicious Wine and Food Pairings

Sipping premium wines and nibbling gourmet goodies can be even more delightful when enhanced by the perfect ambiance, and Sonoma County wineries deliver a variety of special settings to enjoy the fruit of the vine and garden. One of Sonoma County’s first wineries to offer upscale food pairings, the elegant Bubble Room at J Vineyard & Winery features a delicious multi-course tasting menu. And the 90-minute, multi-course seated tasting at St. Francis Winery & Vineyards is so delightful; it was named the number one restaurant nationwide on Open Table in 2013 and 2015. Many other Sonoma County wineries also offer delicious and unique food and wine pairings.

Actually in the Vineyard

While driving, biking or walking by row after row of grapevines makes for wonderful views, it’s even better when you can get in the vineyard yourself — and Sonoma County offers a variety of ways to do that.

The Sonoma Vineyard Adventures program lets you take a self-guided walk on easy pathways through vineyards at participating wineries. Or sit back, relax and let two big, beautiful horses pull you through vineyards on a five-mile tour with The Wine Carriage. Perhaps you’d like to ride a mountain bike on gravel vineyard roads on the guided Cycling in the Vineyard tour by Sonoma Valley Bike Tours? Or maybe you’d prefer to ride the bio-diesel-tractor-powered tram through the bio-dynamic vineyards at Benziger Family Winery? Learn more about the various methods for exploring Sonoma Wine Country.

Celebrating the Fruit of the Vine

Sonoma County hosts a number of events all year round that feature wine, food, music, art and a lot of fun.

On a January weekend, meet winemakers, tour wineries, and sample wine from more than 100 participating wineries throughout the Russian River area at the annual Winter Wineland. In February, sample wines from the barrel on the Wine Road in the Russian River Valley. And in April the Winegrowers of Dry Creek Valley host Passport to Dry Creek Valley, showcasing wine paired with food, plus entertainment, as well as special bottlings available only during Passport.

Warm weather brings the Summer Concert Series at Rodney Strong Vineyards, offering music and wine all summer long. In August, music is also a strong draw at the Seafood, Art and Wine Festival in the town of Bodega, about five miles inland from the Pacific Coast.

Over Labor Day weekend, Sonoma State University’s Green Music Center hosts Taste of Sonoma, one of the biggest celebrations each year that features hundreds of wines, local chefs, and the Sonoma County way of life, all with a backdrop of musical inspiration. A few weeks later, the Sonoma County Wine Auction brings together wine superstars, local celebrity chefs, and honored guests with imaginative and indulgent auction lots, highlighted by exquisite wine and cuisine, and all to raise money for Sonoma County nonprofits.

October brings Pinot on the River, a fun-filled weekend focused on Pinot Noir in the wine country town of Healdsburg. In November, enjoy a weekend of wine and food pairings in the Alexander, Dry Creek, and Russian River Valleys during the Wine & Food Affair.

And Sonoma County wineries typically go all out for the holidays, with bright lights, colorful decorations, music and events like the Heart of Sonoma Valley Holiday Open House.

This is just a quick overview of a few of the annual Sonoma County festivals. For more details, check the Sonoma County Calendar of Events.

Plan Ahead

Having trouble deciding what to do first? Check the listings of special Sonoma County deals to find a money-saving offer that lets you discover the beauties and abundance of Sonoma Wine Country.

Rent A Car & Spend A Day In Sonoma Find Culinary Delights in Sonoma County

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A thorough understanding of the physical and mechanical qualities of your products is vital if you are to demonstrate the safety, quality  and durability of your products to customers and reduce the risk of product returns or recalls.

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SGS is a world leader in conducting physical and mechanical tests on the safety, stability and reliability of samples for a wide range of industries, including consumer goods,retail and automotive.

Supported by a global network of over 1,200 laboratories and offices, and the most highly skilled experts in their field, our physical and mechanical testing services have both an international reach and a knowledge of local regulatory requirements, so you can be confident that while we are creating a program of tests to meet your particular expectations we also have an eye on the expectations of your customers and regulators.

Our physical testing services include:

  • Stability tests
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  • Weather conditioning

They can be used as stand-alone tests or integrated into a wider program that includes mechanical testing methods identifying potential problems such as:

  • Fracture
  • Adhesion
  • Deformation
  • Fatigue

Mechanical and physical testing services can be applied at any stage of production, from the testing of the qualities of raw materials to examining the durability of completed products. They are conducted on a hugely diverse range of materials and products, including cosmetic and hygiene products, sports and leisure products, home furnishings, packaging, toys and novelty items and car interiors.

SGS physical and mechanical tests help businesses give their products a competitive edge by demonstrating their durability, stability and safety to customers. Our consultants are available to advise on the benefits they could bring to your business.


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Surface water testing helps ensure it is safe for drinking and leisure pursuits.

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Surface water testing ensures drinking and bathing water quality as well as to protect ecosystems and biodiversity.

Surface water refers to lakes, rivers, creeks, wetlands, and streams –  water bodies which are typically sensitive to the effects of contamination and often serve as a source of fresh water, for various purposes including the supply of drinking water.

Surface water regularly shows the presence of contaminants. For example, when surface water is treated with disinfection chemicals, such as chlorine, chlorine dioxide, ozone, or bromine, reaction with natural organic matter can also create toxic or carcinogenic by-products. Contamination can originate from agricultural chemicals, such as pesticides and fertilizers, as well as industrial, commercial, shipping or landfill effluent.

SGS surface water testing

SGS offers an extensive range of analytical testing services for surface water, including but not exclusively:

  • Full range of organics analysis (hydrocarbons, polycyclic aromatic hydrocarbons (PAH), pesticides, volatiles, PCB etc.)
  • Full range of inorganics analysis including heavy metals
  • Quantification of ultra-trace metals
  • Metal speciation
  • Microbiological parameters
  • Major anion and cation identification
  • Nutrient identification

Why choose SGS?

Offering superior service and 24-hour support, we are experienced in identifying all forms of contaminants in surface water. Wherever you are in the world, we have the local expertise backed up by global capabilities, to help.

For more information on surface water testing, contain your local SGS office.


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Pairs Trading Hour Show – September 10, 2020

Tom Cook

Pairs Trading Hour Show hosted by Tom Cook Topics discussed in this show……. 1. Kicking Off The Show, “Peaks & Valleys” w/ Banking, Retail & Energy Pairs Strategies & QueenBee(TM) Set-ups, & New Pie Charts To Our Premium Spreadsheet” 2. Equity Pairs trading Strategies, & Great Management Set-ups With Profile! 3. In-depth strategic look at […]

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Home Outfits Summer Suede & the Shopbop Sale

Summer Suede & the Shopbop Sale

April 12, 2017

Suede for summer makes total sense when paired with an off the shoulder ruffle top, jeans and mules. It’s an easy going outfit that doesn’t take itself too seriously. And yes, my obsession with ruffles continues, here and here. P.S. I wouldn’t be kind if I didn’t tell you the Shopbop sale starts today! Spend under $500 and save 20%, spend over $500 and save 25% with code EVENT17. Check out my top picks below. Currently I have these jeans, this tank, and this dress in my cart. Sale ends 4/14, so hurry go get your size!

what I’m wearing: suede jacket similar and similar :: sage top :: jeans  :: sunnies :: lip color Stila in beso :: Photo’s by Tasha ::

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Update on Plastics - Current information that you should know for yourself and your family.

I wanted to update you on plastics and BPA's with a new study from the University of North CarolinaSimon Fraser University, and Cincinnati Children’s Hospital  which has linked aggressive behavior in two year old girls to their mother's exposure of BPA's.  Boys whose moms had the highest BPA levels exhibited slightly
more internalizing behaviors, but
 the association was not as strong as that seen in girls, study researcher Joe M. Braun told WebMD

BPA's are found in most plastics, the lining of some cans as well as many other commercial goods.  BPA was found in the urine of more than 90% of Americans in a random sample conducted by CDC researchers in 2007.  For almost 10 years, scientists have debated whether exposure to BPA through commercial products poses a health threat to humans. Hundreds of animal studies suggest it might, but only a few human studies have been published.

For this study, urine samples were taken from 249 pregnant women in Cincinnati, Ohio, at 16 weeks and 26 weeks of pregnancy, and again at birth. BPA concentrations in the samples were measured. Then, when the children were 2 years old, behavior problems were assessed, using the Behavioral Assessment System for Children-2 (BASC-2).

Although this new information is far from conclusive, the study, published in the journal Environmental Health Perspectives, is the first to examine if there is a link between prenatal bisphenol A (BPA) exposure and behavior problems in children. Results suggest that if a woman is exposed to BPA early in her pregnancy, development of the baby’s nervous system might be adversely affected.

“Many government agencies and consumers in the U.S., Canada and around the world have expressed concerns about BPA exposure, especially in children,” said Dr. Bruce Lanphear, professor of children’s environmental health in the Faculty of Health Sciences at Simon Fraser University and the study’s senior author. “Canada has banned BPA in baby bottles and other baby products, but that might not be sufficient to protect children. Although this is the first study of its kind, it suggests that we may also need to reduce exposures during pregnancy.”

Take the precautionary principal on this one, whether you are pregnant or not,  and try to steer clear of BPA's.  That means staying away from plastic water bottles too.  According to a Harvard study, drinking from a plastic water bottle raises your BPA levels 70%.  Using a stainless steel re-usable water bottle may be much safer for you and certainly much better for our environment in terms of waste and petroleum use in manufacturing.

But watch out...SIGG, a trusted manufacturer of BPA-free water bottles for adults and older kids, is facing a class-action lawsuit because they continued to call their products BPA-free despite having a liner that contained BPA. Consumers are angry that SIGG's CEO announced that the aluminum bottles were free of chemicals that scientists have deemed harmful when the bottles did contain small amounts of BPA.

Keep an eye out for products marked BPA free and never, ever heat plastics.  When preparing your ready made meals that come in plastic, just take them out and place them in glass or ceramic dishes before microwaving.  It's easy.

Remember, this is not about guilt...it's about the power you gain  from information you obtain...it's about the power of knowledge.

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"Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has." - Margaret Mead


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My research and teaching focus on digital rhetoric, technical communication, and social advocacy - how emerging writing technologies can connect people to local issues and create platforms for social change.

Digital platforms and mobile technologies are changing how and where we write. My work examines how the material tools and technologies of writing shape not only the way we read, write, and circulate information, but also how we can better articulate local discourse, amplify marginalized voices, and mobilize civic action.

Hi, I'm Shannon.

I also work with students and members of the community to design engaging, data-driven learning experiences.

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Mobilizing Paris

An augmented reality learning experience that teaches the history of power and protest in the streets of Paris.

An interactive, award-winning mobile app that helps people understand climate change within their local community.

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My courses and workshops socialize learners - creating an environment where people can share knowledge, promote best practices, and support each other.

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Charter Oak Church Directory

Charter Oak Church Directory

The Charter Oak Church Guide provides descriptions of local Christian churches, cathedrals and other places of Christian worship in Charter Oak Iowa. Maps are included. If you are a resident, visitor or are preparing to relocate within the city limits, you will find this information useful. With it you can connect with other congregations in your area, find a like-minded church to worship while visiting, or have the information you need to begin searching for a new home church.

About Charter Oak - Background Information

Total population530
Median Age: Female45.5
Median Age: Male39.1
Number of households245
Median Income$33,482

Source: 2000 census, U.S. Census Bureau


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Wrong is Wrong

Since the election of Barack Obama, the GOP–aka “the party of no”–has shown impressive discipline, putting party orthodoxy ahead of both the common good and, frequently, sanity. The Democrats, on the other hand, have happily confirmed Will Rogers’ great line: “I’m not a member of any organized political party; I’m a Democrat.” The left wing of the party has pretty constantly criticized the President for not doing more, not doing it more quickly, and not doing what they wanted.

I’ve considered much of this criticism unfair–often it has been the result of not understanding the constraints imposed by Separation of Powers, or the magnitude of the economic threat he inherited. Other complaints have had more merit–contrary to Republican rhetoric, for example, Obama has often seemed too willing to compromise, too reluctant to play hard-ball. But by far the most serious criticism has been his acceptance of Bush-era infringements on civil liberties.

This is a man who taught Constitutional law, a man who stood up for the rule of law as a Senator and who said all the right things as a candidate. It was a relief, after 8 years of a profoundly lawless administration, to cast a vote for someone who could be expected to respect Constitutional limits. That expectation has proved illusory, and Obama’s embrace of Bush-era surveillance measures has been painfully disappointing.

The recent announcement that the President would not veto the current Defense bill , however, is worse. While much of the bill is uncontroversial,  its counterterrorism section states that the entire world, including American soil, is a battlefield in the war on terror, and that the U.S. military thus has the authority to arrest and indefinitely detain anyone, even citizens, suspected of aiding terrorists.

I can’t think of anything more profoundly unAmerican.

It’s bad enough that large numbers of Congressmen and Senators support this assault on the Constitution and the rule of law. For Obama–who clearly knows better–to sign it is simply inexcusable.  Laura Murphy, the longtime head of the ACLU’s Washington office, said it best:

“If President Obama signs this bill, it will damage both his legacy and American’s reputation for upholding the rule of law. The last time Congress passed indefinite detention legislation was during the McCarthy era and President Truman had the courage to veto that bill. We hope that the president will consider the long view of history before codifying indefinite detention without charge or trial.”

In ordinary times, when we had two responsible political parties, the loyal opposition would provide a corrective to Executive Branch over-reaching. The saddest thing about the farce that is our current political environment is that no such counterbalance exists; indeed, the major movers of this appalling provision include Lindsay Graham and the ever-angrier John McCain. The same GOP that contests the power of the White House to reform health care evidently has no problem handing over the power to arrest and indefinitely detain American citizens.

We can only hope the Supreme Court remains sufficiently “activist” to invalidate this incredibly unAmerican measure.

3 thoughts on “Wrong is Wrong

  1. What you, and many other, seem to forget is that the democrats still control the Senate as well as the Presidency. Where were the Senate democrats in all this? To blame the republicans when the democrats have the power is ludicrous. It seems to me that you are reaching to assign blame.

  2. I didn’t vote for BHO in the last elections but I may do so this next time around. Anyone with the last name of BUSH does NOT belong anywhere in government. Period. Read Kitty Kelly’s “The Family” and you will see why neither George HW Bush nor GWB will ever stand trial for their many crimes.

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