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Who have you seen in concert or would like to...

Hi! I just found out that I'm going to get to see the Backstreet Boys (They're a Boyband for those of you not familiar with them) in concert in August... I'm so very excited!!! I've seen them in concert three times already (I only saw all five members... I didn't go to any concerts when it was just the four of them.) And I saw Nick Carter in concert once... I'm so excited... my family is going to make a day of it and visit Boston for the day and then in the evening I'll go to the concert and my parents will go out to dinner.

So a question to all of you... who have you seen in concert and who would you like to see in concert?

In addition to the Backstreet boys I would love to see Nightwish, Within Temptation, and Leaves' Eyes (all Gothic Rock bands) in concert, but I haven't had the opportunity yet.

Looking forward to hearing who all you have seen or want to see...

I love concerts and have been able to see some great performances. My favorites were (ok, dating myself here, lol) Crosby, Stills, Nash & Young, Neil Young, Queen, Pink Floyd, Rush, Queensryche, The Scorpions and Metallica. My concert going days are pretty much behind me but I would still love to see Tim McGraw, Little Big Town, Nickleback and Lady Antebellum.

I would love to see any of the ones you've seen, especially Crosby, Stills, Nash and Young... and I wish I had had the opportunity to see Queen live when Freddie was still alive! I saw a televised concert of his back when he was still alive and I was blown away by his showman ship... truly a gifted man. Your whole list rocks though... I'm not really into country though, but I would be willing to see Tim McGraw or Lady Antebellum... and Nickleback is a personal favorite... I go through phases where I listen to nothing but their music for weeks... right now my phase is a 30 seconds to Mars phase though... but it was nickleback a few weeks ago...lol.

I've gone to so many concerts I'm not sure I could list them all! And, up until a few years ago, we used to go to this 4-day music festival held ever year in the summer (it started out @ Loon Mtn, but now they hold it at Gunstock Mtn).

Here's a partial list: Squeeze, Joan Jett, Til Tuesday, Katrina & the Waves, Don Henley, The Cure, The Alarm, U2, Boston, Pat Benatar, Def Leppard, Eric Burden & the Animals, The Police, Newsboys, Mercy Me, Superchick, Paul Colman Trio, DC Talk, Toby Mac, FFH, Big Daddy Weave, Rebecca St. James, Nate & James, Steel Guitar festival in Maui, etc.

I once had an opportunity to go see the Rolling Stones & Rush (had a friend who could get me tickets), but my mom said that she'd get them & we'd go together........only she didn't. I was SO bummed.

Mine are a bit dated....Peter, Paul and Mary; SOS (Society of Seven - a group in Hawaii), The Association, Gloria Loring and the best one of all times....Barry Manilow!

I have always wanted to go to a Backstreet Boys concert. So jealous smiley

Been to a few concerts but not in the last 12 months. Seen Deep Purple, Slade, Sad Cafe, Nickleback, Five, Dolly Parton, Barbra Streisand, Dean Friedman, David Essex, Alvin Stardust, The Osmonds, some I've forgotten and 2 years ago we went to the Princes Trust Rock festival at the Albert Hall with Tom Jones, Status Quo, Brian May, Paloma Faith, Alison Moyet, Eric Clapton, Phil Collins, Jools Holland, Jamie Cullum plus others but they only played 2-3 songs each. Tom Jones's voice was amazing and he wiped the floor with the others.

I'd like to see some American Country bands like Big and Rich or Toby Keith or Sugarland and I would LOVE to see Muse.

@Janet: I´d love to be in a Peter, Paul and Mary concert!
@Sarah: I didn´t knew that Backstreet Boys still exists...

I´ve never been to a big concert with a international band. I´ve listened to Earth Ensemble once, but it was a small show in an event that there´s in my town yearly, where there are 24h straigth of free happenings. But I´ve been three or four times to the concert of my favorite brazilian pop/rock band, called "Pato Fu", and some other with national groups.

Oh, and totally off-topic, I went to an opera too. It was a fantastic experience! Well, I love classic music...

I have seen: The Moody Blues, The Who, The Pretenders, Green Day, Jimmy Eat World, Matchbox20, Santana, Taking Back Sunday, Poison, Steve Miller, Jefferson Airplane, Ryan Shupe and the Rubberband, The Rolling Stones, George Strait, Martina McBride, Tim McGraw, Throttlebust (my cool friend Bryan's band in Atlanta - you should check them out if you live there), Bon Jovi, Justin Beiber, Hanson, Spice Girls... that is all I can think of really quick - though there are lots more smiley

In July I am going to see New Kids on the Block, 98 Degrees & Boys II Men - with my cousin Amanda. It should be great, especially since I am going with Amanda who was New Kid CRAZY (the curtains, the bedspread, the dolls, shoes, toothbrush.... EVERYTHING) when we were younger.

Okay, I am so jealous of anyone that has seen The Cure in concert.

I haven't seen as many bands in concert: Kenny Rogers, Ronny Milsap, Poison, Cinderella, Queensrÿche, Tesla, Metallica, Joan Jett and Aerosmith.

I would love to see Plain White T's, Three Doors Down, Finger Eleven and Godsmack.

@Marisa... if you do ever get the chance to see them live it's totally worth it, they are stellar showmen and their voices sound even better live...

@Lorien... the Backstreet Boys just celebrated their 20th Anniversary in April and I believe all seven of their studio albums have made it to the top ten on the Billboard charts here in the US, even the two they did without Kevin. Kevin's back now though and their new album drops on July 30th I think... I can't wait... it's two days after my birthday so I'm hoping I can convince my Brother and his wife to buy the album for me for my Birthday!

@Dawn... I agree I would love to see Three Doors Down, Finger Eleven and Godsmack live, especially Godsmack... I listen to their stuff all the time... Love his voice!

@Dawn: I was pretty lucky - one of my sorority sisters was into the Cure big-time & introduced me to their music... She, knowing what a music hound I am, dragged me to their concert. We had a ton of fun...

A lot of my concert going days was during college, going with college buddies to concerts. Some were on-campus and others were in Boston (MA), Worcester (MA), Hampton Beach (NH), Loon Mtn or Gunstock Mtn (NH), Laconia (NH), Old Orchard Beach (ME), Civic Center in Portland or Lewiston (ME), Providence (RI), Burlington & Barre (VT), Montreal (Quebec), and at a few coffee houses or churches in New England. The 3-day music festival I talked about earlier (SoulFest) debuted around the time my eldest turned 3 and, up until 4 yrs ago when our vintage camper was totaled, we'd reserve tickets for it every summer (staying in the campground in our camper). That festival has 100+ bands every year with a lot of big-name Christian artists/bands there. It was a lot of fun, and occasionally you'd get to interact with various band members.

@Sarah: Wow, those 20 years past very fast... Feeling old now o.O

@Lorien... no kidding right? I was still in high school when they formed and now it's twenty years later... I think this May was seventeen years since I graduated from high school... and I watched the BSB on Good Morning America the other day and they still have little kids in the audience who weren't even born yet when I saw them live the first time... and my worker was two years old when the band formed... this getting old thing is crazy...

I went to an awesome (AWESOME!) Paul McCartney 's show here in Brazil lately but that's pretty much it.
Can we post about Stage Plays too? Because I am really excited I am going to see Toby Stephens in July. Yay!!!!!
@Lórien: I love Pato Fu too!!!!!!! And Skank! (Jelous!) smiley

@Sarah: This is the problem... I was in the 7th grade when I first heard BSB.

@Cinthia: I used to like Skank more later... Sepcially their first albums. But I haven´t seem them live. Well, when I lived in Minas Gerais there were a festival that was broadcast though radio, and I heard them smiley But if broadcasts count I saw Psy show another day, lmao.

Pato Fu is my favorite Brazilan band, I´ve been a fan since 1997 or so. Takai´s voice is soooo sweet. (If you wanna hear her singing, to know what we are talking about, hear this cover of cities in dust). She and Karen Carpenter are my favorite female pop singers smiley

Last year I finally got to see Snow Patrol in concert and it was better than I ever could have imagined!!! And this month I finally get to see The Airborne Toxic Event and I can't wait!!!

I have never been to a concert! There are plenty that I'd love to go see but I've just never had the money for them or my anxiety gets in the way (I don't do the whole huge crowd thing!) I think my top 5 would have to be One Direction (LOL I'm a 13 year old stuck in a 24 year old's body), I would have loved to seen Queen live back in the day, Rush, Ke$ha and Miguel. I have an extremely diverse taste in music smiley

Haven't been to a concert in ages! I think TobyMac was the last one I went to.

@Jenn: Oh, I love TobyMac!

I've mostly been to country concerts; Garth Brooks, Sawyer Brown, Alan Jackson to name a few. My favorite though was just a couple years ago, before Chris Young blew up into a big deal and he was at a little bar in Billings Montana. Had my picture taken with him and about died lol. The only non country concert that isn't a local band was Def Lep back in the 80's

@Sherrilynn... nothing wrong with having diverse taste in music... I found this questionnaire (in fact I think I might have gotten it on a blog belonging to one of the pixel scrapper regulars... can't remember who though so if it's you let me know and I'll credit you smiley ...) anyhow the questionnaire was '30 things my children should know about me'... now I don't have any children but I woke up last night and could not fall back to asleep so I filled it out and one of the things I put was some of my favorite bands and artists... I had everybody from BSB to Britney to Kelly Clarkson, Kid Rock, Linking Park, Limp Bizkit, Lorena McKinnet, a bunch of Irish/new age singers... Pitbull, Everlast, and a bunch of Gothic Rock bands... oh and can't forget New Kids on the block...lol... anyways my point is having an eclectic mix of musical interests just gives you more to talk about when music comes up in conversation... not that I need more to talk about since most times folks can't get me to shut up, but I'm sure you get my point... more power to you!

@Lorien... Gosh I feel old... I was in college the first time I heard the BSB... lol. and it's not like I was late coming to the party... I 'discovered' them in 1998 when they performed 'Everybody' on the VMAs... I was sitting in my friends Dorm room watching and she went to change the channel and I begged her to wait till the song was over...lol. she did and the next day I went out and bought their two CDs... and the rest as they say is history... of course it took about a year before I was willing opt publicly admit that I liked them and owned their CDs but that's cuz I had a brat of a brother who liked to pick on my musical tastes... even though I bought him the Britney CD he wanted...lol.

I have not got to alot just 2. As the issue was things always going on in life that kept me from doing what I want. I saw Mandy Patinkin in concert. And my absolute very favorite concert that I have always wanted to go to last year was Bret Michaels. I can still die a very happy woman to this day knowing I saw that man in concert.

@Sarah: It´s on Caffeine Fuelled Momma´s blog I guess. Or in Jessica Fors´. I know it´s in one of our friends that have little newborns. Also LOL at your brother. Don´t feel old, it could be worst...

@Sarah - I love Backstreet Boys too! I have only seen them in concert once. It was when I was 14 and they were at the height of their popularity. It was before Millenium came out. I still adore them and I would love to see them again live!

@Jody - I'm jealous! I got to see Crosby, Stills, & Nash, but Young wasn't there. =/

@Lizanne - I would LOVE to see Joan Jett and Pat Benetar!

@Dawn E - I've also seen Nickelback and Five. =P I'd love to see Eric Clapton. smiley

@Kaleena - I've also seen Green Day and Jimmy Eat World! I've seen both bands a handful of times each. I've actually met both bands more than once and they are all super nice guys. smiley I would love to have seen Spice Girls back when they were popular. I loved them so much! =P And I'm jealous that you've seen The Who and Poison. =P

@Dawn W - I've seen Aerosmith too! Steven Tyler is a wonderful guy. I go to meet him back in 1997. I saw them several times on that tour. I'd love to see Metallica and Joan Jett! If you get the chance to see Plain White Ts then I recomment it! I saw them back before they got really popular. They were very nice as well. And I've also seen Three Doors Down, Finger Eleven, and Godsmack. They all put on great live shows. smiley I hope that you are able to see them someday.

I have seen so many concerts that I would never be able to remember them all. That was my thing when I was a teenager. My friends and I would go to concerts just about every weekend. We always had to drive at least four hours though since we lived out in the country. =P We almost always got to meet the bands that we went to see too, which was awesome! You can really tell a lot about a person from the way that they treat others.

Here are some that I can remember off the top of my head: Aerosmith, Red Hot Chili Peppers, Foo Fighters, Green Day, Blink 182, Jimmy Eat World, Kid Rock, Tenacious D, Muse, Black Eyed Peas, Everclear, Nickelback, 'N SYNC, Backstreet Boys, Five, No Doubt, Garbage, Lit, The Distillers, Lucky Boys Confusion, Fall Out Boy, Plain White Ts, All American Rejects, Michelle Branch, Weezer, Thursday, Bush, Stone Temple Pilots, Lynyrd Skynyrd, The Offspring, Incubus, Staind, Dave Matthews Band, AFI, Rilo Kiley, Cursive, The Faint, Tilly and the Wall, Bright Eyes, Poison The Well, Story of the Year, My Chemical Romance, Eve6, P.O.D., Rise Against, gosh I could go on and on. =P

Fab list Vanessa! Do you do the summer festivals? I've never been to one but my son has and he racked up a ton of bands in a fairly short space of time. Eric Clapton was everything I wanted him to be. If you get the chance, go!

@ Dawn - Oh I love summer festivals! I have been to tons of them. I used to attend the Beale Street Music Festival in Memphis, TN every year when I was in high school. It is a three day music festival and it is so much fun! And I have also been to a lot of radio station sponsored music festivals where there are numerous bands playing on different stages. I really miss going to so many concerts, but I got married and had kids so my time and money were a little more crunched. =P

You've all been to impressive concerts. For me it's been a while, but in the past i have seen: Guns 'n roses, UB40 (about 5 times smiley ) , Tom Jones (i think 4 times) , Engelbert Humperdinck (3 times) , Paul Potts, Luciano Pavarotti, Shakin Stevens, Freddy Fender, Robin Gibb, The Kelly Family, Julio Iglesias, a lot of dutch singers, and some i forgot. But now, concerts are so expensive.......

@Vanessa In 2001 i have been in Memphis where we went to the Elvis on Tour concert.

I really haven't been to many! Back in the early 90s I saw Yanni... let's see. I went to a Blue Man Group show in Las Vegas, and I've seen Rick Springfield. My mom, sister, and a cousin went to see the Transsiberian Orchestra a couple years ago.

I would LOVE to see Bon Jovi or Pink.

@Sarah Higgins I am definetly familiar with the backstreet boys. LOL Anyways, I've seen Bon Jovi (twice), Nickelback and Creed all in concert. My favorite concerts were Bon Jovi and Nickelback.

Recently a lot of big artists have started touring to South Africa - we all end up going crazy because we don't get a chance to see such awesome artists as often so they are usually shocked at the amount of people at their shows here!

Coldplay is absolutely breathtaking live - definitely one of my favourites! Otherwise I've seen Kelly Clarkson, Red Hot Chilli Peppers, Lady Gaga (her actual performance was way-out there but her acoustic set was beautiful - she really went out of her way to connect with her fans - the crazy people who camped out for 3 days to be in the 'monster pit' - lady gaga version of golden circle... but I did go last minute and with an open mind),
Another of my favourite shows was Two Door Cinema Club (indie), there's also the Kongos, Bullet for My Valentine, Eagles of Death Metal... Going to see Alt-J later this year...
Then I've seen some amazing local talent - namely Shadowclub, Black Handed Kites, Jeremy Loops, aKing, to name a few - if you love music, you should look at some of these and other South African artists,you may be very surprised at the amazing talent a lot of musicians here are showing...

I would absolutely do anything to see Mumford & Sons live... There was a rumour that they were coming this way - but so far it hasn't been confirmed... I will literally camp out like the gaga fans did, that's how serious I am...


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The two breakfast dishes I tried on my family this past week are from the casserole category known as a “strata”. Think of a casserole as a dish that is all mixed together and baked (like a tuna casserole) and a strata as a dish that is layered into the pan and baked (like a […] . . .

As I work my way through my recipe stash, I keep finding themes. Snack bars were definitely one of them. Blueberry muffins, pumpkin pie, and butternut squash soup are a few of the others. And so is this week’s stash busting effort: breakfast casseroles. I found five different recipes in my stash, and decided that […] . . .

I confess that our family does love a good casserole, and this one was no exception. The kiddos the Sweetie Pie husband all agreed that it was delicious, and I’m thrilled to have two more in the freezer! It seems like a pretty predictable casserole recipe, but the cream sauce is homemade, not from a […] . . .

You can’t really call this a shepherd’s pie. It’s made with beef, which I guess would technically make it a “rancher’s pie”. But if you say “rancher’s pie”, no one knows what you’re talking about. So I’m sticking with shepherd’s pie for now. This dish has been in my family recipe file for so long […] . . .

I know I’ve sampled a lot of casseroles from More with Less. Can you bear just one more? Then I’ll do my best to move on to another chapter. This one was a big hit with the family, and I really wished I could have eaten it, too. I thought the idea of using hard-boiled […] . . .

If the day-before-Thanksgiving in your house looks anything like the day-before-Thanksgiving in our house, you probably haven’t put much thought into what’s for dinner tonight. Probably, you’re thinking you’ll order a pizza, or make a trip to the closest taco cart. May I make a suggestion? The Sweetie Pie and the Sweet Pea made this […] . . .

I had doubts about this dish. My doubts were similar to doubts I’ve had about other recipes in More with Less. It just sounded too simple to taste good. Once again, though, my doubts were unfounded. My family ate this up without complaint, asked for seconds, and even requested the leftovers for lunch the next […] . . .

Start This Recipe about 10 hours before you want to eat it Dinner Table Rating 1 thumb per family member Cook’s Rating Accessibility of ingredients, ease of preparation, and affordability This recipe was my attempt to make lemons out of lemonade. Imagine my surprise when it actually worked! Last week I shared with you about my unsuccessful foray […] . . .

I used to be willing (and able) to put a lot of time and effort into cooking. I truly love to eat good food, and the only way to eat the kind of food I wanted to eat was to make it myself. So I did. And it was fun. I didn’t have a “real” […] . . .

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Carddies Sports Review

27 June 2012

Isn't it funny how the things you think might not be enjoyed so much by your children can turn out to be BIG HITS!  This turned out the be the case with the Carddies Sports set that landed on my desk to review.

My youngest son (a whole six years old on Tuesday - much more grown up that being five apparently!) was disappearing off, with his dad, to spend the last half-term on the coast at his nannies house; you know what it can be like going away to stay somewhere else for a week, there's a fine line to be drawn between filling up the car with toys and games so there are plenty of things to do when you're wherever you're going to, or not taking enough activities resulting in you having a bored child on your hands *eek*

The little Carddies Sports set was duly packed off with them to play with whilst Edward and his dad were away, here's what they thought of it...

Carrdies Sports

The box is small - a little bigger than a box of long kitchen matches - and contains 12 hand-drawn sporty looking characters on thick white card,  coloured pencils to bring your Carddies to life, 12 plastic stands to stand them in and a hand-drawn sporty cardboard scene.

Simon was pleased that the Carddies box was so small, bearing in mind the amount it contained, "The Carddies colouring set is small enough to fit in your hand or a 'man bag', making them very portable and perfect for entertainment either on the move - long plane or train journeys, for example," he comments.

Once you've coloured in your Carddie characters and background scene, imaginative play can commence with abandon and you can have your Carddie sportsmen and women partaking in your very own Olympic Games or school sports day; the only limitations here is going to be a lack of imagination.

Simon notes that the patriotic and supporters of 'best of British' among you will be pleased to know that Carddies sets are manufactured 100% in the UK.

The Carddies story is a lovely one - they came about as the result of Raquel and her three children being stuck indoors during a particular rainy seaside holiday.  She drew little characters on the cardboard from cereal packets for her kids to colour in and they loved them.

Raquel then joined forces with her sister, Esther, and the Carddies business was launched;  between them they have seven children - the seven advisers who give their ideas for packaging and new characters - and Raquel and Esther still draw all the designs for the Carddie characters today.

It's a great story isn't it, especially as the Carddies range has become so popular and now boasts over 200 characters.

Both Edward and Simon really enjoyed the Carddies Sports experience, "We loved playing with the Carrdies, both the colouring and the making up games and stories with them afterwards.  I might even have enjoyed playing with them a little bit more than Edward," Simon confesses, "there is something about colouring that you never grow out of!"

Thinking outside the Carddie box, Simon and Edward also came up with another use for the 12 Carddie characters.

"If you should get fed up making up sports games for the characters to play, then you can use them for a game of 12-pin bowling - or 10-pin and two spectators -  simply arrange them in a triangle and bowl them over with a screwed up piece of paper."

A marvellous idea I thought!

And finally...

Simon and Edward give the Carddies Sports set a huge thumbs up and Simon absolutely believes that, at £8.99, they are fabulous value for money and would happily buy more Carddies sets to add to the Sports set.

"This is a great activity set easy enough for all ages;  enough pieces for several kids to play with at the same time and small enough to conveniently take it away on days out, long journeys and holidays!" Simon concludes.

I asked both him and Edward for an overall score out of 10 and they both gave a resounding 10 out of 10; Edward says I must tell you that they're, and I quote, "Awesomely AWESOME!"

What do you think?

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Action Machining IB 1.5 Body Only For 1-1/2" AFI Filter

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This AFI Clear Action Filter with Mesh Screen from Action Machining Inc. is designed to provide protection from debris clogging you lines while maintaining an economical cost and is great for smaller use applications such as small commercial and residential. With a clear canister for easy inspection and high pressure rating often associated with secondary water systems.

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Brasstech 449/15 Polished Nickel Brass Nipple

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The Brasstech 448 brass nipple is designed for drain applications in residential and commercial areas. This nipple goes with wall mounted sinks and is a waste draining system. This product is a solid brass constructed nipple that is used to connect the sink drain to the P-trap. To prevent rust and corrosion, Brasstech coated this 448 slip extension with a polished nickel finish. The brass nipple and finish are protected against manufacturing defects and tarnishing with the limited lifetime Brasstech warranty. This product features a 6 long pipe with a 3/8 IPS threaded ends. This Brasstech 449/15 Polished Nickel Brass Nipple is one of the many amazing product made by Brasstech that is featured on This is the perfect place for anyone who is looking to complete their kitchen or bathroom, with the highest quality merchandise available!

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The Malco De14 is a 1/4" Double End Drill Bit. This double-ended drill bit is designed with two points for twice the life and twice the convenience.

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Panasonic WXGA 3LCD Multimedia Projector 5000 Lumens / Mfr. No.: Pt-Ew540u

Panasonic WXGA 3LCD Multimedia Projector 5000 Lumens / Mfr. No.: Pt-Ew540u
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The PT-EW540U WXGA 3LCD Multimedia Projector from Panasonic is a 5000 lumens bright installation class projector that features a native resolution of WXGA (1280 x 800) and a 16:10 native aspect ratio. Featuring an interchangeable lens design, the projector includes the standard lens, a motorized zoom lens which features a 1.7 to 2.8:1 throw ratio. Additionally, it is compatible with a range of separately available lenses from Panasonic, including short throw, zoom, and long throw options.

Designed to be connected to a variety of video sources, for A/V setups of all kinds, the projector supports computers, DVD and Blu-ray players, video switchers, and even legacy analog equipment. It features a VGA input on standard 15-pin connector, a 5-BNC multi-analog input that supports VGA (RGBHV), Component, Y/C (adaptable to S-Video), and composite, a DVI-D (digital only) input, a DisplayPort input, and an HDMI input. It supports HDCP so you can use the projector to watch copy-protected content such as commercial Blu-ray discs, and both the HDMI and DisplayPort inputs support embedded audio as well. For analog audio sources there are three stereo analog audio inputs, two on 3.5mm mini jacks and one on a two-RCA left and right channel stereo pair. Audio can be output through the 10W built-in monaural speaker or sent to a downstream audio device, such as a PA system, via a 3.5mm stereo mini jack audio output. An audio only mode allows audio output even when the picture is switched off. Finally, there is a VGA output that mirrors the VGA input so that a second device, such as a computer monitor, can receive the same signal.

The projector can be controlled locally via side-panel buttons or using the included IR remote. There is an IR extender port in case the installation makes direct line-of-sight communication impossible. Remote control with software or third-party systems is also possible thanks to an Ethernet port at two RS-232 serial ports. The RS-232 port can be used for computer control or integration with automation system such as Crestron. Meanwhile the Ethernet port with Panasonic PJLink protocol support allows IP-based operation from Panasonic software or a Web browser. Alternatively, the Ethernet port can be configured for Panasonic Digital Link, so that HD video and control signals can be sent over a single Ethernet cable when using the projector attached to compatible devices that support HDBaseT.

  • 5000 Lumens; 4000 Hour Lamp Life

  • WXGA (1280 x 800) Native Resolution

  • 16:10 Native Aspect Ratio

  • VGA, 5-BNC, DVI-D, DisplayPort Inputs

  • HDMI, Composite, and Stereo Audio Inputs

  • VGA and Audio Outputs

  • Supports RS-232 and Ethernet Control

  • HDBaseT and Digital Link Compatible

  • Supports Lens Shift on Most Lenses

  • Includes 1.7 to 2.8:1 Throw Ratio Lens

Display System 3-Chip 0.76" / 1.93 cm LCD
Native Resolution WXGA - 1280 x 800
Format NTSC
NTSC 4.43
PAL 60
Brightness 5000 Lumens
Aspect Ratio Native: 16:10
Contrast Ratio Not Specified By Manufacturer 1

Please Note:

With lamp power set to AUTO and Picture Mode is in DYNAMIC

Dynamic Contrast Ratio 2000:1
Focus Auto
Lens F 1.7 - 2.3 (f = 26.9 - 45.4 mm)
Lens Shift Vertical: ±60%
Horizontal: ±10% 2

Please Note:

Note: When the optional fixed-focus lens (Model ET-ELW21) is attached, shift adjustment is not available.

Throw Ratio 1.7 - 2.8:1
Keystone Correction Vertical: ± 40°
Horizontal: ± 30°
Picture-in-Picture Yes
Ceiling Mountable Yes
Rear Screen Projection Yes
Built-in Speaker Yes, 10W (Mono)
Input/Output Connectors
Inputs/Outputs 1x 15-pin VGA Video (Input)
1x 5-BNC Video (Input)
1x 15-pin VGA Video (Output)
1x DVI-D Video (Input)
1x HDMI Audio/Video (Input)
1x DisplayPort Audio/Video (Input)
2x 1/8" (3.5 mm) Mini Audio (Input)
1x RCA Stereo (L/R) Audio (Input)
1x 1/8" (3.5 mm) Mini Audio (Output)
1x RS-232C Control (Input)
1x RS-232C Control
1x 1/8" (3.5 mm) Mini Remote (Input)
1x Ethernet Control 3

Please Note:

5-BNC input supports RGBHV, Component, and Composite

Lamp (Bulb) 1x UHM
Watts 335W
Life Normal Mode: 4000 Hours
Fan Noise Normal Mode: 35 dB
Eco Mode: 29 dB
Remote Control Yes
Security Cable Lock Slot
Languages English
Power Requirements 100-240 VAC, 50/60 Hz
Power Consumption Normal Mode: <485W
Standby Mode: <4W 4

Please Note:

34 W when in STANDBY MODE with audio output set to ON; <= 4 W otherwise

Temperature Operating
32 to 113°F (0 to 45°C)
Humidity: 10 - 80%
Dimensions (WxHxD) 20.9 x 7.0 x 17.5" / 530.9 x 177.8 x 444.5 mm with included lens
Weight 23.4 lb / 10.61 kg with included lens
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Puppy Dog tooth scratch

Gud Afternoon Doctors... Yesterday while returning from office I was petting a street pup. While petting its tooth scratched my finger. So I went to a doctor and he examined it and said that it has just scratched your skin no flesh wound. So he prescribed me to take a TT injection and I did as said. So now I just wanna know if this TT would do the Job or should I visit a doctor?? Please help...
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Dr. Manju Lihala Bangalore | General Physician
Yes TT is enough. You don't need to take anti rabies vaccine since only skin scratch is there.
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 Namrata Goswami - PRIO

Namrata Goswami

Research Fellow, IDSA

Namrata Goswami

Recent publications

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Book Chapter

Goswami, Namrata(2008) Eastern Neighbourhood: Is the North Eastern Region on Board? IDSA Asian Strategic Review. : (xx–xx).

Popular Article

Miklian, Jason; & Goswami, Namrata (2008) Losing a New Game with the Same Old Moves, Outlook India, 3 December.
Miklian, Jason; & Goswami, Namrata (2008) India's Violent Internal Dissent, Economic and Political Weekly, 24 May.


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Farmers will now become Agri entrepreneurs

India’s largest Agri Tech India Expo to commence at Bengaluru on August 25
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July 16, 2012 - PRLog -- The Netherlands is the partner country of this show, while the focus countries are Turkey and Italy, who are putting up big pavilions and 17 other countries.
An offshoot of the fascinating saga of India’s transition from agriCulture to agriBusiness is the proliferation of mega expos to showcase the latest achievements in agriculture and allied activities.
In India, the transformation in agriculture being showcased through expos is becoming the focus point for drawing delegations and trade visitors, thereby adding value to Indian agriculture, food processing and other employment-generation activities.
Former Prime Minister H D Deve Gowda, an ardent champion of the farming community and agriculture development, is scheduled to inaugurate the three-day show on August 25. There will be over 350 stalls apart from open to sky display of farm equipments from various companies. Total area will be over 14,000 sq mtr.
Interestingly in the show, almost 50% space has been booked by overseas exhibitors. New Range of Agri equipment, farm mechanisation solutions, pre & post harvest management machines and inputs, value addition in food processing plants from countries like Canada, USA, Spain, Russia, Turkey, Holland, France, Germany, Israel, China, Indonesia, Italy, Taiwan etc will be on display.

“Foreign companies manufacturing farm machinery and processing equipment view India as a potential market, since interest in farm mechanisation and on-site value addition have escalated in this country of late,” said Naqvi. “Through this show, we are trying to bridge the gap between farmers and suppliers of farm machinery and equipment, not only from India but also from countries like Holland, Turkey, Italy, Germany, China and Israel, as farm solutions in these countries are more user-friendly. Imports of such equipment and machinery into India are on the rise,” he added.

The success of Ratnagiri’s Agri Mart, Champion Agro Retail, DCM’s Hariyali Bazar and Godrej’s Aadhaar and ITC’s e-Chaupal are proven examples of a spurt in demand for farm equipments and machinery. They are launching new outlets and hiring the youth for sales and marketing to cater to increasing demand.
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TOPIC: Simulator Pass/Fail Question

Simulator Pass/Fail Question 8 months 1 week ago #6963

  • Christopher Cunningham
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Hello: What is considered a pass on the simulator quiz? I received a 70% score on my quiz and its showing I failed under My Results ->My Statistics.

Simulator Pass/Fail Question 8 months 1 week ago #6964

  • Cornelius Fichtner
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  • Posts: 966
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The PM Exam Simulator does not give you a "pass"fail" per se. Instead, it reports the same three Proficiency Levels that you will see on the real PMI exam report. It uses the following fixed percentages to determine the levels:
  • Proficient > 85%
  • Moderately Proficient >= 75%
  • Below Proficient < 75%
Please note that these are the percentage ranges that have been chosen by our team of experts for the simulator. We do not know how exactly PMI scores the real exams.
Until Next Time,
Cornelius Fichtner, PMP, CSM
President, OSP International LLC
The following user(s) said Thank You: Christopher Cunningham
Moderators: Yolanda Mabutas, Ahmed Amin, Michael DeCicco, Rahul Kakkar, Fernando Jr Sinlao Lim, Jeremy Raelin, Mary Kathrine Padua, Yasir Mehmood, Chris Preziotti, Lazard Toe, MPM, CIPM, PMP, ITIL, Christian Winter, Kevin Nason, Michael Sumaquial, PMP, Mark Wuenscher, PMP


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US Modern & Early Silver Commemorative Coins

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After 1954, the US Mint did not produce a Commemorative Coin for nearly 30 years. In 1982, the George Washington Half Dollar was released to celebrate the 250th birthday of the nation’s first president--making it the first Modern US Commemorative. Annually thereafter, the US Mint continued to produce Commemoratives in the denominations of Clad Half Dollars, Silver Dollars, $5 Gold Coins and $10 Gold Coins. Commemoratives are generally struck as Satin Finish Uncirculated Coins or Proofs.

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This spring I am teaching an upper-level leadership seminar. In this course, we will review research and theory on leadership and discuss the most compelling questions about leaders and leadership. I am inviting you to join us.

Each week we will post some of the lessons learned, review some of the class discussion, and wrestle with questions about leadership and its importance to society. In addition, students will work on developing their own leadership skills in the class, so there will be plenty of tips for your own leadership development.

The idea is for you to follow along virtually. Hopefully, you will get the sense of being in the class as we explore leaders and leadership. I'll try to provide links for additional information and for your own study of leadership topics. And, you can join in the discussion with your own comments and questions via this blog. I'll share with the class and with you.

Let's begin. First, let's talk about the course content and expectations. The course is, as you can imagine, very psychological in nature. Psychologists have studied leadership for more than 100 years, so there is a rich background of theory and research on the topic. In the course, we will use a textbook by Richard L. Hughes, and his coauthors, Ginnett & Curphy (6th edition). Of course, I don't expect you to buy an expensive, new text, but you can find older editions of this book, or other leadership texts, on-line for a few dollars. Besides the Hughes book, I recommend the texts by Northouse and one by Yukl. You could even pick up a copy of an early edition of my I/O psychology text for as low as 33 cents and read the chapter on leadership.

How much work is involved? (you might be asking yourself). Only as much work as you want to do! (after all, you're not paying tuition [you don't want to know how much our tuition is] or getting a grade). But let me try to persuade you to follow along, so we can call this, "Why I love the study of leadership."

Leadership is the most complex of human phenomena. Leadership, or at least the notion of dominance hierarchies, is "hard-wired" into us. As social animals, we have evolved a sense of leading and following for survival purposes. The history of civilization, is, in many ways, the history of social movements. Whether it is the great dynasties, the wide-ranging religious movements, the nations, the wars, or just local politics, it is all about this collective process that we call leadership. So, lesson one is that leadership is not just abut the great leaders. Leadership is a process of leading and following. It is a shared, collective process.

I also love leadership because while the study of leadership is fascinating, it is also a very practical subject. We are all leaders in some area of life, and by studying good leadership, we can become better leaders (and better people - but more on that in the future).

So, I hope you will join us for all or part of the course. Feel free to add your own thoughts and ideas to the ongoing discussion. As I tell my students, the more you put into the course, the more you will get out of it.

Follow me on Twitter:!/ronriggio

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While I've never been impressed with the argument that SSRIs work a whole lot better than placebo, I am becoming impressed with the list of SSRI-related side effects. I'm also willing to bet that your healthcare provider did not discuss how serious the sexual side effects can be or that they might be potentially irreversible.

Men who are taking SSRIs should be aware of the potential impact of this class of drugs on their sexual function and fertility.

SSRIs and Male Sexual Function

I mentioned this in an October 3 posting, but am repeating it because of the latest findings that I've listed in the section that follows (SSRIs and Male Fertility).

According to the Journal of Sexual Medicine (January, 2008), any person who has been given a prescription for an SSRIs should be provided with a warning such as the following: "There is a high probability of sexual side effects while on SSRI medications. There are indications that in an unknown number of cases, the side effects may not resolve with cessation of the medication and could be potentially irreversible."

SSRIs and Male Fertility

If you are a man who is taking SSRIs, here's what we know to date about this class of drugs and male fertility. The following is from an announcement issued a few weeks ago by The American Society for Reproductive Medicine as reported by Reuters [please note the part about how a routine sperm test is unlikely to pick up on this kind of sperm damage]:

Treatment with paroxetine (Paxil), which belongs to the selective serotonin reuptake inhibitor (SSRI) class of antidepressant drugs, increases DNA fragmentation in sperm, according to research presented today at the 64th annual meeting of the American Society for Reproductive Medicine in San Francisco.

Although the study did not directly evaluate male fertility, the five- fold increase in the number of men who developed abnormal sperm DNA while being treated with paroxetine is "troubling" and "suggests an adverse effect on fertility," said co-investigator Dr. Cigdem Tanrikut, from Harvard Medical School in Boston,.

In a clinical trial she described as "the first study to assess the impact of an SSRI on semen parameters in healthy men," 35 men took paroxetine for 5 weeks. The drug was administered in once-daily doses of 10 mg the first week, 20 mg in the second week, 30 mg the third and fourth week, and 20 mg in the fifth week.

Tests were conducted on semen samples obtained prior to starting paroxetine and after 4 weeks of treatment. The average DNA fragmentation score increased from 13.8 percent before paroxetine was begun to 30.3 percent at week 4, a statistically significant amount.

The percentage of men who had a fragmentation score of 30 percent or higher before treatment rose from 10 percent to 50 percent.

Semen analyses conducted throughout the study, however, showed normal volume, concentration, movement and appearance.

Paroxetine was also associated with significant sexual dysfunction, with one third of men reporting problems with erectile function and nearly half reporting ejaculatory difficulties.

"DNA integrity is crucial to normal fertility," Tanrikut said. For example, increased DNA fragmentation of sperm increases the risk of failure of intrauterine insemination.

"Abnormal sperm DNA integrity even affects pregnancy outcomes of the most advanced assisted reproductive technologies, such as in vitro fertilization (IVF)," she added. "In fact, it is the only male factor finding that has been shown to affect intracytoplasmic sperm injection (ICSI) results."

"A large proportion of patients on (SSRIs) may have their fertility affected," co-investigator Dr. Peter N. Schlegel, at Weill Medical College of Cornell University in New York, observed in correspondence with Reuters Health.

Among infertile men taking an SSRI, "a standard semen analysis won't measure this effect," Schlegel pointed out, and "a special test for DNA fragmentation...should be considered."

The sperm appears to be damaged by a slowing down of their transport through the body, "a novel mechanism of damage," he said. "Most agents affect fertility by knocking down sperm production. Slowing down sperm transport can allow sperm to be damaged (by higher temperatures, or just 'getting too old' -- being ejaculated after they should have been)."

"We have seen severe cases where the sperm are slowed down so much that almost no sperm appear in the ejaculate."

Based on these findings, the research team is planning larger studies using other SSRI antidepressants.

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P&T News

October 20

Device bypasses expensive ‘clean rooms’
Chlamydia, gonorrhea, and syphilis take double-digit jumps
First new initial treatment of STS in more than 40 years
Desmopressin nasal spray gets ‘thumbs up,’ with reservations

October 19

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Insoluble compound traps potassium ions
Therapy meets primary endpoint in phase 3 trial

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Funds intended for clinical studies evaluating drugs, biologics, medical devices, or medical foods
Researchers suggests stronger regulatory oversight of endocrine-disrupting chemicals
Product will cost 15% less than the current wholesale acquisition cost of Remicade
Though declining in number, they’re particularly important in underserved areas

October 17

Clinicians advised that current tools underestimate fracture risk in these patients
Previously unexplained symptoms associated with multiple copies of a single gene
Penalty illustrates U.S. government’s emphasis on combating health care fraud
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Combining immunotherapeutic treatments with antiestrogen drugs may extend survival


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    Kylie Minogue is an icon to millions of fans who have followed her remarkable career for over a decade. From 'Neighbours' to Stock, Aitken and Waterman, to her current disco revival at the top of the charts, Kylie has morphed into some staggering creations over the years, carrying off all of these incarnations with style and flair, whilst constantly remaining in vogue and assuring her longevity.

    This intimate biography, written by the incomparable Jenny Stanley-Clarke, PR agent to many high profile celebrities, explores the real girl behind the many guises. Using her wealth of contacts, Jenny Stanley-Clarke provides us with the most informative portrait of one of pop's most private stars.

    Kylie's personal life, shrouded in secrecy is examined closely, from her key relationships with Michael Hutchence and Jason Donovan to the influence of men such as Prince and Nick Cave and the competitive career of her younger sister, Dannii.

    Exposing the personal and professional highs and lows that have created a star who has had chart-topping hits spanning three decades, 'Naked' is a biography as glittering as Kylie herself.

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    By: E B Sledge

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    This was a brutish, primitive hatred, as characteristic of the horror of war in the Pacific as the palm trees and the islands

    Landing on the beach at Peleliu in 1944 as twenty-year-old new recruit to the US Marines, Eugene Sledge can only try desperately to survive. At Peleliu and Okinawa two of the fiercest and filthiest Pacific battles of WWII he witnesses the dehumanising brutality displayed by both sides and the animal hatred that each soldier has for his enemy.

    During temporary lapses in the fighting, conditions on the islands mean that the Marines often cant wash, stay dry, dig latrines, or even find time to eat. Suffering from constant fear, fatigue, and filth, the struggle of simply living in a combat zone is utterly debilitating.

    Yet despite horrendous conditions Sledge finds time to keep notes that he would later turn into a book. Described as one of the finest memoirs to emerge from any war, With the Old Breed tells with compassion and honesty of the cruelty, bravery and deaths of the men he fought alongside, and of his own journey from patriotic innocence to batte-scarred veteran.

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Closeted Businessman Embezzled $280,000 To Pay Off Blackmailer Wife

Screen Shot 2013-02-26 at 1.46.36 AMA director at a UK luxury-goods store claims he embezzled nearly $280,000 to pay off his now-ex wife, who was blackmailing him over his secret gay life.

Christopher Brown, 55, claimed he used the money he siphoned from upscale retailer Dawson’s to pay off his then-wife, Mandy, in 1997. She had apparently discovered her husband had been calling gay chat lines.

Mandy supposedly threatened to out her husband unless he agreed to an “outrageous spending limit.” The money went to pay for private school for their son, as well as fancy restaurants, hotels and a trip to Florida, according to Mr. Murphy’s attorneys.

Murphy’s wife denies her husband’s version of the story.

Mr. Murphy, who now lives in France with his male companion, plead not guilty to four counts of theft. Nonetheless he was found guilty, and is serving a two-year-prison term. He claimed he only “borrowed” the money, and repaid more than $180,000 over two years.

“You chose to siphon off cash from company business accounts to fund your own financial expenditure,” proclaimed Judge Recorder James Watson  “‘I do take into account the pressures upon your life and the shame of being unable to admit to yourself your sexuality.”

Mr. Brown initially refused to return to Britain for questioning., but was eventually arrested in France in 2011.

“Only the stability of Dawsons helped it to weather the financial storm,” said Detective Constable Andrew Stuckes. “Mr Brown had to be forced to return from abroad and has now, rightly, been held to account for his actions.”

Brown’s lawyer tried to claim his client was acting fairly morally: “He didn’t believe he was acting dishonestly; some of the stolen funds were repaid. It was a very unusual set of circumstances; he was a loyal and decent employee for years.”

Yeah, right up until he embezzled almost a third of a million dollars.

On:           Feb 26, 2013
Tagged: , , ,
    • yaoming

      “Trips to Florida”? If I were blackmailing my husband in the UK, I’d probably pick someplace more exciting.

      Feb 26, 2013 at 4:25 pm · @ReplyReply to this comment ·
    • Ruhlmann

      @yaoming: Hahaha! I’ve been. Never again.

      Feb 27, 2013 at 3:02 pm · @ReplyReply to this comment ·

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TX Rep. Louie Gohmert Opposes Gun Control Because Gay Marriage Will Lead To Bestiality

louie gohmertIt was only a matter of time before nutbag Republicans synthesized their two hot topics of hatred: gay marriage and gun control. Now Rep. Louie Gohmert (R-Texas) has done it splendidly, clearly explaining how limiting the number of rounds in a magazine is like marrying your dog.

In a conference call with reactionary activist Rick Scarborough Gohmert said:

In fact, I had this discussion with some wonderful, caring Democrats earlier this week on the issue of, well, they said “Surely you could agree to limit the number of rounds in a magazine, couldn’t you? How would that be problematic?”

…And I pointed out, well, once you make it ten, then why would you draw the line at ten? What’s wrong with nine? Or eleven? And the problem is once you draw that limit; it’s kind of like marriage when you say it’s not a man and a woman any more, then why not have three men and one woman, or four women and one man, or why not somebody has a love for an animal?

There is no clear place to draw the line once you eliminate the traditional marriage and it’s the same once you start putting limits on what guns can be used, then it’s just really easy to have laws that make them all illegal.

He also masterfully linked marriage equality to Obamacare:

You need to educate yourselves on the issues: You need to understand that when there is a law being pushed, as it has for several years, that says that religious institutions should not be exempt from discrimination laws, that it is going to devastate the church, the synagogue, the places of worship that hires people. Because ultimately they’re saying you have to hire whatever Satan-worshiper, whatever cross-dresser you think might be immoral, that’s against your religious belief.

You are going to be forced to abandon your religious beliefs, and we’ve been seeing that with some of the requirements under Obamacare.

And they called Reagan the Great Communicator!

h/t: LGBTQNation

On:           Apr 3, 2013
Tagged: , , , ,
    • Cam

      The GOP has now lost two national elections by trying to continually scare people about “The Gays” and getting these nutbag right wingers as their candidates.

      If they want to continue the trend, then by all means keep electing these folks.

      Apr 3, 2013 at 11:14 am · @ReplyReply to this comment ·
    • Caleb in SC

      @Cam: I couldn’t agree more. The Republicans refuse to get off of their tired script of hatred and oppression. Jesus, I hope their time machine has enough power to transport all of them back to the 1950s.

      Apr 3, 2013 at 12:09 pm · @ReplyReply to this comment ·
    • MuscleModelBlog.com

      You both are very correct. Actually, I think the Republicans are realizing that the country is becoming a lot more socially liberal, and that spewing hatred about gays, denying women the right to have abortions, etc.,…is not going over as well as it used to. They need to make some changes if they want to be competitive nationally.

      Apr 3, 2013 at 5:01 pm · @ReplyReply to this comment ·
    • Dresden

      This guy’s a lightweight. He conflates same-sex marriage with polygamy and bestiality; cross dressing with Satan worshiping… and yet, he doesn’t even have the decency to throw pedophilia in there somewhere. I’m disappointed.

      Apr 4, 2013 at 2:21 am · @ReplyReply to this comment ·
    • Harley

      So if the Christian Taliban wants to discriminate against gays, atheists, whatever, then can we discriminate against these same Christian Taliban? I think not.

      Apr 4, 2013 at 5:55 am · @ReplyReply to this comment ·
    • DOFEK

      Louie Gohmert, YOU ARE MENTALLY ILL! and fucked up. You need to smoke more POT. AdamHomo
      PS: he thing he is white.

      Apr 4, 2013 at 9:38 am · @ReplyReply to this comment ·

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(This article was first published on R Chronicle, and kindly contributed to R-bloggers)

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Warburg effect

Raquel Guimarães Coelho, Juliana de Menezes Cazarin, João Paulo Albuquerque Cavalcanti de Albuquerque, Bruno Moulin de Andrade, Denise P Carvalho
Acceleration of glycolysis is a characteristic of neoplasia. Previous studies have shown that a metabolic shift occurs in many tumors and correlates with a negative prognosis. The present study aimed to investigate the glycolytic profile of thyroid carcinoma cell lines. We investigated glycolytic and oxidative parameters of two thyroid carcinoma papillary cell lines (BCPAP and TPC1) and the non-tumor cell line NTHY-ori. All carcinoma cell lines showed higher rates of glycolysis efficiency, when compared to NTHY-ori, as assessed by a higher rate of glucose consumption and lactate production...
October 4, 2016: Oncology Reports
Tatjana Harting, Mandy Stubbendorff, Saskia Willenbrock, Siegfried Wagner, Patrik Schadzek, Anaclet Ngezahayo, Hugo Murua Escobar, Ingo Nolte
The Warburg effect describes the ability of cancer cells to produce energy via aerobic glycolysis instead of oxidative phosphorylation of pyruvate. This deviation in mitochondrial metabolism inhibits apoptosis, allowing increased proliferation under conditions of reduced oxygen levels. Dichloroacetate (DCA) was successfully used in several human cancer cell lines to reactivate oxidative phosphorylation in mitochondria. The aim of this study was the characterization and response of canine cancer cell lines after DCA exposure...
October 5, 2016: International Journal of Oncology
Juan Yang, Cun Wang, Fengbo Zhao, Xiaoying Luo, Meilin Qin, Einthavy Arunachalam, Zhouhong Ge, Ning Wang, Xuan Deng, Guangzhi Jin, Wenming Cong, Wenxin Qin
Reprogrammed metabolism has been identified as an emerging hallmark in cancer cells. It has been demonstrated that fructose-1, 6-bisphosphatase 1 (FBP1) as a rate-limiting enzyme in gluconeogenesis plays critical roles in tumor initiation and progression in several cancer types. However, function of FBP1 in hepatocelluar carcinoma (HCC) is still not clear. In this study, we observed that the expression of FBP1 was obviously downregulated in the cell lines and tissues of HCC. Downregulation of FBP1 in HCC tissues was correlated with a lower overall survival rate and had a relatively higher tendency of tumor recurrence (n = 224)...
October 14, 2016: Carcinogenesis
Jingtao Luo, Yun Hong, Xiaoan Tao, Xi Wei, Lun Zhang, Qiang Li
Unlike normal cells, cancer cells are recently identified to rely on aerobic glycolysis for energy production called the Warburg effect. Several attempts are being made to target this metabolic reprogramming pathway in treating cancers; however, the successful rate is very limited. In this study, we investigated the functional roles of fatty acid oxidation key enzyme carnitine palmitoyl transferase 1a (CPT-1a), during the metabolic programming of pancreatic ductal adenocarcinoma (PDAC) cells induced by glucose deprivation...
October 13, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Siroon Bekkering, Bastiaan A Blok, Leo A B Joosten, Niels P Riksen, Reinout van Crevel, Mihai G Netea
BACKGROUND: Innate immune memory or 'trained immunity' has recently been described as an important property of cells of the innate immune system. Due to the increased interest in this important new field of immunological investigation we sought to determine the optimal conditions for an in-vitro experimental protocol of monocyte training using three of the most commonly used training stimuli from the literature: β-glucan, the Bacille Calmette-Guérin (BCG) vaccine, and oxidized LDL (oxLDL)...
October 12, 2016: Clinical and Vaccine Immunology: CVI
Bradley Smith, Xenia L Schafer, Aslihan Ambeskovic, Cody M Spencer, Hartmut Land, Joshua Munger
Metabolic reprogramming is critical to oncogenesis, but the emergence and function of this profound reorganization remain poorly understood. Here we find that cooperating oncogenic mutations drive large-scale metabolic reprogramming, which is both intrinsic to cancer cells and obligatory for the transition to malignancy. This involves synergistic regulation of several genes encoding metabolic enzymes, including the lactate dehydrogenases LDHA and LDHB and mitochondrial glutamic pyruvate transaminase 2 (GPT2)...
October 11, 2016: Cell Reports
Yaqing Li, Ruixia Huang, Xiaoli Li, Xiaoran Li, Dandan Yu, Mingzhi Zhang, Jianguo Wen, Mariusz Adam Goscinski, Claes G Trope, Jahn M Nesland, Zhenhe Suo
Pyruvate dehydrogenase A1 (PDHA1) serves as a gate-keeper enzyme link between glycolysis and the mitochondrial citric acid cycle. The inhibition of PDHA1 in cancer cells can result in an increased Warburg effect and a more aggressive phenotype in cancer cells. This study was conducted to investigate the expression of PDHA1 in ovarian cancer and the correlation between PDHA1 expression and the prognosis of patients. The PDHA1 protein expression in 3 ovarian cancer cell lines (OVCAR-3, SKOV-3 and ES-2) and 248 surgically removed ovarian carcinoma samples was immunocytochemically examined...
2016: American Journal of Cancer Research
Shubha Gururaja Rao
Mitochondrial structural and functional integrity defines the health of a cell by regulating cellular metabolism. Thus, mitochondria play an important role in both cell proliferation and cell death. Cancer cells are metabolically altered compared to normal cells for their ability to survive better and proliferate faster. Resistance to apoptosis is an important characteristic of cancer cells and given the contribution of mitochondria to apoptosis, it is imperative that mitochondria could behave differently in a tumor situation...
October 8, 2016: Handbook of Experimental Pharmacology
Min Peng, Na Yin, Sagar Chhangawala, Ke Xu, Christina S Leslie, Ming O Li
Aerobic glycolysis (the Warburg effect) is a metabolic hallmark of activated T cells, and has been implicated in augmenting effector T cell responses including expression of the proinflammatory cytokine interferon-γ (IFN-γ) via 3' untranslated region (3'UTR)-mediated mechanisms. Here, we show that lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic glycolysis but promotes IFN-γ expression independently of its 3'UTR. Instead, LDHA maintains high levels of acetyl-coenzyme A to enhance histone acetylation and transcription of Ifng Ablation of LDHA in T cells protects mice from immunopathology triggered by excessive IFN-γ expression or deficiency of regulatory T cells...
September 29, 2016: Science
Jorgelindo da Veiga Moreira, Minoo Hamraz, Mohammad Abolhassani, Erwan Bigan, Sabine Pérès, Loïc Paulevé, Marcel Levy Nogueira, Jean-Marc Steyaert, Laurent Schwartz
To better understand the energetic status of proliferating cells, we have measured the intracellular pH (pHi) and concentrations of key metabolites, such as adenosine triphosphate (ATP), nicotinamide adenine dinucleotide (NAD), and nicotinamide adenine dinucleotide phosphate (NADP) in normal and cancer cells, extracted from fresh human colon tissues. Cells were sorted by elutriation and segregated in different phases of the cell cycle (G0/G1/S/G2/M) in order to study their redox (NAD, NADP) and bioenergetic (ATP, pHi) status...
October 3, 2016: Metabolites
Taro Sugiyama, Kohei Taniguchi, Nobuhisa Matsuhashi, Toshihiro Tajirika, Manabu Futamura, Tomoaki Takai, Yukihiro Akao, Kazuhiro Yoshida
The metabolism in tumor cells shifts from oxidative phosphorylation to glycolysis even in an aerobic environment, which phenomenon is known as the Warburg effect. This effect is regulated mainly by polypyrimidine tract-binding protein 1 (PTBP1), which is a splicer of the mRNA for the rate-limiting enzymes of glycolysis, pyruvate kinase muscle 1 and 2 (PKM1 and PKM2). In the present study, we demonstrated that miR-133b reduced PTBP1 expression at translational level and that the expression levels of miR-133b were significantly down-regulated in gastric cancer clinical samples and human cell lines, whereas the protein expression level of PTBP1 was up-regulated in 80% of the 20 clinical samples of gastric cancer examined...
October 3, 2016: Cancer Science
Neeta Pandit-Taskar, Darren R Veach, Josef J Fox, Howard I Scher, Michael J Morris, Steven M Larson
Castration-resistant prostate cancer (CRPC) is the lethal form of prostate cancer, and more than 26,000 men will die from this disease in 2016. The pathophysiology of CRPC is clearly multifactorial, but most often, androgen receptor (AR) upregulation is associated with its earliest beginnings and the AR increase is part of the multimolecular complex including downstream effector proteins linked to AR (AR-axis) responsible for rapid proliferation and malignant features of the malignant cell. In both animal models and patients, glycolysis (Warburg effect) is also an early manifestation of CRPC transformation...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Hossein Jadvar
Imaging of the Warburg effect, which is the principal but not the sole cause for enhanced glucose metabolism in tumors, with PET and (18)F-FDG has become the mainstay for the imaging evaluation of several cancers. Despite the seemingly prevalent notion that (18)F-FDG PET may not be useful in prostate cancer, relatively limited evidence suggests that this imaging modality can be useful for the evaluation of the extent of metastatic disease and the assessment of the therapy response and prognosis in men with castration-resistant prostate cancer...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Jingtao Luo, Yun Hong, Yang Lu, Songbo Qiu, Bharat K R Chaganty, Lun Zhang, Xudong Wang, Qiang Li, Zhen Fan
Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, we investigated how acetyl-CoA carboxylase (ACC), a downstream target of AMPK, rewires cancer metabolism in response to cetuximab treatment. We found that introduction of experimental ACC mutants lacking the AMPK phosphorylation sites (ACC1_S79A and ACC2_S212A) into head and neck squamous cell carcinoma (HNSCC) cells protected HNSCC cells from cetuximab-induced growth inhibition...
September 28, 2016: Cancer Letters
Suraj Peri, Elena Caretti, Rossella Tricarico, Karthik Devarajan, Mitchell Cheung, Eleonora Sementino, Craig W Menges, Emmanuelle Nicolas, Lisa A Vanderveer, Sharon Howard, Peggy Conrad, James A Crowell, Kerry S Campbell, Eric A Ross, Andrew K Godwin, Anthony T Yeung, Margie L Clapper, Robert G Uzzo, Elizabeth P Henske, Christopher J Ricketts, Cathy D Vocke, W Marston Linehan, Joseph R Testa, Alfonso Bellacosa, Levy Kopelovich, Alfred G Knudson
Tumor suppressor genes and their effector pathways have been identified for many dominantly heritable cancers, enabling efforts to intervene early in the course of disease. Our approach on the subject of early intervention was to investigate gene expression patterns of morphologically normal "one-hit" cells before they become hemizygous or homozygous for the inherited mutant gene which is usually required for tumor formation. Here, we studied histologically non-transformed renal epithelial cells from patients with inherited disorders that predispose to renal tumors, including von Hippel-Lindau (VHL) disease and Tuberous Sclerosis (TSC)...
September 22, 2016: Oncotarget
Seong M Kim, Saurabh G Roy, Bin Chen, Tiffany M Nguyen, Ryan J McMonigle, Alison N McCracken, Yanling Zhang, Satoshi Kofuji, Jue Hou, Elizabeth Selwan, Brendan T Finicle, Tricia T Nguyen, Archna Ravi, Manuel U Ramirez, Tim Wiher, Garret G Guenther, Mari Kono, Atsuo T Sasaki, Lois S Weisman, Eric O Potma, Bruce J Tromberg, Robert A Edwards, Stephen Hanessian, Aimee L Edinger
Oncogenic mutations drive anabolic metabolism, creating a dependency on nutrient influx through transporters, receptors, and macropinocytosis. While sphingolipids suppress tumor growth by downregulating nutrient transporters, macropinocytosis and autophagy still provide cancer cells with fuel. Therapeutics that simultaneously disrupt these parallel nutrient access pathways have potential as powerful starvation agents. Here, we describe a water-soluble, orally bioavailable synthetic sphingolipid, SH-BC-893, that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways...
September 26, 2016: Journal of Clinical Investigation
Amanda L Peterson, Adam K Walker, Erica K Sloan, Darren J Creek
Cancer cells often have dysregulated metabolism, which is largely characterized by the Warburg effect-an increase in glycolytic activity at the expense of oxidative phosphorylation-and increased glutamine utilization. Modern metabolomics tools offer an efficient means to investigate metabolism in cancer cells. Currently, a number of protocols have been described for harvesting adherent cells for metabolomics analysis, but the techniques vary greatly and they lack specificity to particular cancer cell lines with diverse metabolic and structural features...
2016: Metabolites
Kinga A Kocemba, Joanna Dulińska-Litewka, Karolina L Wojdyła, Przemysław A Pękala
The high rate of glucose breakdown is the fingerprint of cancer. Increased glycolysis allows tumour cells to fulfil their high energetic and biosynthetic demands. Interestingly, however, rather than metabolizing glucose in the oxidative phosphorylation pathway, cancer cells generally use glucose for aerobic glycolysis. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental forms of metabolic reprogramming during cancerogenesis. Changes in the rate of glycolytic activity of cancer cells are caused mainly by the increased expression of glycolytic enzymes as a consequence of activation of oncogenes or loss of tumour suppressors...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
Álvaro Marín-Hernández, Juan Carlos Gallardo-Pérez, Ileana Hernández-Reséndiz, Isis Del Mazo-Monsalvo, Diana Xochiquetzal Robledo-Cadena, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
The accelerated growth of solid tumors leads to episodes of both hypoxia and hypoglycemia (HH) affecting their intermediary metabolism, signal transduction and transcriptional activity. A previous study showed that normoxia (20% O2 ) plus 24 h hypoglycemia (2.5 mM glucose) increased glycolytic flux whereas oxidative phosphorylation (OxPhos) was unchanged vs. normoglycemia in HeLa cells. However, the simultaneous effect of HH on energy metabolism has not been yet examined. Therefore, the effect of hypoxia (0...
September 23, 2016: Journal of Cellular Physiology
Shreeram C Nallar, Dhan V Kalvakolanu
Cytokines induce cell proliferation or growth suppression depending on the context. It is increasingly becoming clear that success of standard radiotherapy and/or chemotherapeutics to eradicate solid tumors is dependent on IFN signaling. In this review we discuss the molecular mechanisms of tumor growth suppression by a gene product isolated in our laboratory using a genome-wide expression knock-down strategy. Gene associated with retinoid-IFN-induced mortality -19 (GRIM-19) functions as non-canonical tumor suppressor by antagonizing oncoproteins...
September 15, 2016: Cytokine & Growth Factor Reviews
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