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How We Implement

The Expertise to Help You Navigate Change & Implement ERP

Selecting the right ERP system for your organization is only half of the battle.  Implementing a complex, business information management system on the magnitude of an Infor ERP system requires tremendous knowledge and years of hands-on experience.  Since such an initiative touches every major business function within your organization, we consider a successful implementation mission-critical to your business.  That’s why it’s vitally important you have access to the planning and execution expertise that only a seasoned business partner can bring to the table.  A seasoned partner like Guide Technologies has the skills and knowledge to help you successfully implement ERP.

With a 95% on time, on budget implementation track record, Guide’s Professional Services team is staffed by experienced manufacturing and technology experts who have the skills and knowledge to deliver a successful implementation for your organization.  Our team can also add significant value by helping you leverage your technology investment in the future to meet today’s—and tomorrow’s—business challenges.

“Implementation Intelligence 5” —Proven. Precise. Successful.

Created as a result of years of successful implementations, Guide offers clients a proven implementation methodology called “Implementation Intelligence 5 or i25.  This meticulously-executed methodology addresses each aspect of the implementation process, from project management, to the impact of change on personnel, to education and training, to post implementation support.

Each phase of i25 is highly customized to meet the unique needs of your company and how you want to operate.  Our process will minimize your risk, reduce disruption and drive business value so you can maximize the return on your ERP investment.

Guide I25 Benefits:

  • Delivers faster ROI than our competitors
  • Reduces risk and exposure before implementation
  • Addresses technical, business, project management and also human factors of change
  • “Low disruption” approach reduces impact on day-to-day operations
  • Designed to rapidly and efficient implement multiple global locations

PHASE 1: Discovery

During this phase, the project kickoff meeting will be organized and the project charter and project definition documents will be agreed upon between the client and Guide.

PHASE 2: Solution Design

The design phase ensures that the final solution meets your goals and objectives, detailing the expected business benefits and how we intend to achieve them in the shortest possible time.

PHASE 3: Build

Our Build phase consists of cut-over planning, where we develop a cut-over plan and test it; data mapping and conversion planning to convert your existing data to the new system; and end user training so your staff knows exactly how to perform their jobs using the new system.

PHASE 4: Deploy

Guide Consultants work with your project team during the cut-over period to execute the cut-over plan and ensure a smooth transition to the new system.

PHASE 5: Support

This phase includes our post go-live support, where we help your project team ensure everything is functioning at peak performance for the first few weeks or few months.  We also conduct a post implementation review to ensure that your ERP system will continue to meet the future needs of your business.


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Answers from contractors near loveland, OH

What is the best way to clean smudges and marks off of walls painted with flat paint?
Aug 27, 2017
Typically flat paint is not cleanable, unless your flat paint is Sherwin Williams Duration or Emerald in which case you can use some warm water and a sponge. If it’s not one of those two products you ... read more
I moved into a new house about a year ago. All of the toilets seem to be a little cheap in that:
Call a plumbing professional.  That way the toilets can be evaluated.  You would not want to flush money down the drain on repairs if you are going to have to end up replacing the toilets in the near ... read more

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Wampler The Doctor

Availability: IN STOCK NOW!

FREE USPS Priority 2-3 Day Shipping in the U.S.!

The Doctor will see you now.

Born from a collaboration between Brian Wampler and superstar, tele-master Brad Paisley, The Doctor Lo-Fi Delay pedal exudes a gritty character that works as well for laying down an ambient sonic bed as it does for old-school slapback. Give the pedal’s Rate and Depth knobs a spin, and the self-oscillating repeats easily become an aural wash that, while not interfering with the notes you’re playing, is still far from subtle. And the pedal’s straightforward control layout - such as onboard tap tempo control with four easily selectable rhythmic subdivisions - makes use of The Doctor Lo-Fi Delay a triumph over many of the menu-based delay engines of today. Brian Wampler and Brad Paisley know guitar tone. Take a tip from them and add the lo-fi delay goodness of The Doctor to your pedalboard. We think you’ll find it’s right in your Wheelhouse.

There are few tones more addictive to guitarists than the runaway repeats of a self-oscillating delay. With The Doctor, you can put that glorious chaos underneath your playing as an ambient cloud that is anything but pristine. We think you’ll find that Brian Wampler has succeeded in expertly balancing the line of tonal radiance and grainy disintegration like precious few delay pedal creators before. The Lo-Fi repeats that become a sonic bedrock for your tone, working along with the modulation, and the 100% analog, untouched signal path for your original/through tone.

Plug it in, step on the footswitch, and be inspired. That’s how easy The Doctor Lo-Fi Delay is to use. Unlike many menu-based digital pedals, Wampler wants you to be able to twist a few knobs and get the exact tone you’re looking for. If reading manuals and scrolling through deep menus makes you sick, we have just The Doctor for you... The Doctor has been carefully engineered to be plug-and-play ready with an intuitive control layout that will be familiar to most players and absolutely no menu diving or confusing computer-based editors.

The onboard tap tempo footswitch and Sub Divisions (quarter, eighth, dotted eighth, and triplets) button are effortlessly accurate o giving you on the fly rhythmic control -  making sure the repeats that are every bit the musical instrument as your guitar and amplifier. We have even included an external tap tempo in/out control. This allows you to connect another compatible pedal and have The Doctor control its delay time, or have it control The Doctor – the days of tap tempo tap dancing are numbered!

So, as we said above, The Doctor will see you now, and your prescription is ready!

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Sig P220 Match Target

For Sale from Harry Smith |
Positive feedback: 100% View |
| 3 Completed Sales
Sig P220 Match Target  Guns > Pistols > Sig - Sauer/Sigarms Pistols > P220
Description: 45ACP with Adjustable Night Sights

Condition: New In Box
Caliber: .45 ACP
Location: AL

Trades Accepted: Please call and verify this is the gun you are looking for.

Shipping Notes: UPS Overnight

Item #: 996805651
Seller Since: Apr. 2006
Seller Level: Verified
This seller is NOT an FFL
City: Trussville
State: AL

Shipping: $45.00
Accepted Payment Methods: Money Order
Returns: No Returns

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|regenC|MC Set || Li Mc miss || || LP Mc miss ||
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Business in Brief

Green groups ready to fight natural gas exports

With the government’s debate over natural gas policy approaching, a group of environmental and social justice groups said yesterday they would work together to oppose exports. “We won’t allow the gas companies to export Israel’s most vital strategic resource,” the Headquarters Fighting Gas Exports group said in a statement. “Israeli gas must serve Israelis and the Israeli economy. Israel isn’t Nigeria or the Congo.” The opponents of exports are demanding that the issue be debated in the Knesset and not given to the government to decide alone. Two weeks ago more than 60 lawmakers signed a petition to hold a parliamentary debate on the issue. The government’s Tzemach committee recommended last year allowing exports so long as there was enough reserves to ensure supplies to the domestic market for the next 25 years, or some 450 billion cubic meters. (Itai Trilnick)

Homebuyers’ financial condition declined 2.7% in March

Bank Hapoalim’s Mishkan Index, which tracks the financial condition of homebuyers in Israel, fell 2.7% for March following a 1.7% rise in home prices, the bank reported yesterday. According to the survey, over the past 12 months home prices in Israel have risen by a nominal 10.5%, or 8.2% after inflation. There was also a slight increase in interest rates on mortgages, it said. The Mishkan Index combines data on changes in home prices, mortgage rates, average wages and unemployment rates to estimate the affordability of housing. Hapoalim said new-home sales maintained a high and steady rate but that the supply of unsold new homes has declined. Relatively low interest rates and expectations that taxes will be going up in the months ahead have contributed to continued demand, it said. (Arik Mirovsky)

Ex-chief of staff Halutz named chairman of job-search firm

Former IDF Chief of Staff Dan Halutz is joining Jobookit Holdings as chairman, the developer of online job recruiting technologies using social networks like Facebook, Twitter and LinkedIn said yesterday. Halutz, who stepped down after the Second Lebanon War, had been serving as chairman of antenna maker Starling Advanced Communications until the business was sold about a year ago. Jobookit was founded in 2008 by Arik Filstein and includes among its investors Rafael Skolnick, Shlomo Shmeltzer and Eli Levy, CEO of HP Software in Israel. The appointment of Halutz is part of an internal reshuffle: Filstein will serve as CEO of closely held Jobookit while Skolnick, the previous chairman, was named CEO of its parent company. (Eran Azran)

Daniel Bar-On


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Apocalypse Now: New Film 'Snowpiercer' Races Ahead of Genre

The world is reduced to a speeding train in South Korean director's first English-language offering.

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Snowpiercer Directed by Joon-ho Bong; written by Joon-ho Bong, Kelly Masterson; with Chris Evans, Jamie Bell, John Hurt, Ed Harris, Tilda Swinton, Octavia Spencer, Ah-sung Ko, Kang-ho Song, Alison Pill


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Turkey Arrests Five in Connection With Istanbul Bombing

Thirteen suspected ISIS militants, including three Russian nationals, are also detained; it's unclear whether the arrests are directly linked to the attack.

Police officers install security barriers at the historic Sultanahmet district, which is popular with tourists, after an explosion in Istanbul, January 12, 2016.

Turkish police have arrested five people suspected of direct links to the deadly suicide bombing that killed 10 Germans in Istanbul's main tourist area, officials said Wednesday.

More than a dozen other suspected ISIS militants were detained Wednesday in other parts of the country and 59 a day earlier, but officials say they don't appear to be tied to Tuesday's attack just steps away from the Blue Mosque in Istanbul's historic Sultanahmet district.

CCTV footage purports to show suspected Istanbul bomber. Police video obtained by Haberturk

One suspect with a link to the attack was detained in Istanbul late Tuesday, Interior Minister Efkan Ala said during a news conference with his German counterpart. He didn't provide further details.

Turkish media said police raided a home in an affluent Istanbul neighborhood, briefly detaining one woman suspected of links to the Islamic State group, although it wasn't clear if she was the suspect Ala was referring to. The Hurriyet newspaper said the woman was detained because a mobile phone — which she had reported stolen — had been used to call the bomber. The paper said she was released after questioning.

Hours later, Prime Minister Ahmet Davutoglu announced the arrest of four other people as part of the investigation. He didn't provide further details about them.

Turkish authorities have identified Tuesday's bomber as a Syrian man born in 1988 who had recently entered Turkey, and officials say he had ISIS links. The Islamic State group, however, hasn't claimed responsibility for the attack.

Turkish media, including newspapers close to the government, identified the bomber as Nabil Fadli and said he was born in Saudi Arabia. Ala confirmed reports that the bomber had registered with a refugee agency, providing fingerprints that allowed officials to quickly identify him, but said the suicide bomber wasn't on any Turkish or international watch lists for ISIS militants.

The impact of Tuesday's attack, while not as deadly as two others last year, was particularly far-reaching because it struck at Turkey's $30 billion tourism industry, which has already suffered from a steep decline in Russian visitors since Turkey shot down a Russian warplane near the Syrian border in November.

Turkish police on Wednesday arrested 13 more suspected ISIS militants, including three Russians, but it wasn't clear if those arrests were directly linked to the Istanbul bombing. The state-run Anadolu Agency said 59 people were detained on Tuesday.

The attack, which also wounded 15 other people — including Germans, a Norwegian man and a Peruvian woman — was the latest in a string of attacks by Islamic extremists targeting Westerners. On Wednesday, Davutoglu, German Interior Minister Thomas de Maiziere and other Turkish officials visited the site of the blast and placed carnations there.

Germany sent a team of investigators to Istanbul on Wednesday from its Federal Criminal Police Office, which is comparable to the FBI, to support Turkish authorities investigating the attack.

Germany's Foreign Ministry said the number of dead Germans in Tuesday's explosion had risen to 10, but de Maiziere said there was no sign that Germans were specifically targeted.

"According to the investigations so far, there are no indications that the attack was directed specifically against Germans, so there can't be any connection to our contribution to the fight against international terrorism," de Maiziere said.

Germany promised Tornado reconnaissance jets to aid military effort against the Islamic State group in Syria following the November attacks in Paris, and they started flying missions from the Incirlik air base in Turkey last week. It also sent a tanker aircraft, as well as a frigate to help protect a French aircraft carrier in the eastern Mediterranean.

Germany already was helping supply and train Kurdish forces fighting ISIS in northern Iraq but has not taken a direct combat role.

Ala urged Turkish citizens and visitors to go about their daily lives, insisting that the country had taken "all necessary security precautions." He said Turkey had detained as many as 220 ISIS suspects in the week prior to the attack.

De Maiziere also said: "I see no reason to refrain from traveling to Turkey" or for people already there to break off their vacations.

Top German and Turkish officials already were scheduled to meet in Berlin next week to discuss Europe's migrant crisis, in which Turkey — which borders both Syria and the European Union — is a key player. De Maiziere said those talks will now also address "the determined fight against terrorism."

"If the terrorists aimed to destroy or endanger the cooperation between partners, then they achieved the opposite," de Maiziere said. "Germany and Turkey are coming even closer together."

German Foreign Minister Frank-Walter Steinmeier said his country would not make any further immediate changes to its travel advice for Turkey but could do so as the investigation into Tuesday's Istanbul bombing progresses. The Foreign Ministry advised Germans after the attack to avoid crowds in public places and outside tourist sites in Istanbul.

The Russians were detained in the Mediterranean coastal city of Antalya, a popular destination for tourists. The state-run Anadolu Agency said the suspects were allegedly in contact with ISIS fighters in conflict zones and had provided logistical support to the group. Ten other people were detained in Turkey's third largest city, Izmir, and in the central city of Konya.

Nearly 3,000 Russians, mostly from the predominantly Muslim North Caucasus, are believed to have gone to fight alongside ISIS militants in Syria. Families of ISIS recruits and human rights activists in the Caucasus have described Turkey as the main gateway to Syria for Russian fighters. Some ISIS fighters of Russian origin are believed to have left ISIS to settle in Turkey, families say.

The victims of Tuesday's blast came from several different parts of Germany and included two couples. Regional authorities didn't identify them but and gave ages only for some, ranging from 51 to 75.

Joerg Manthei, a spokesman for Berlin-based travel agent Lebenslust Touristik, said all 10 of the Germans who were killed had booked their trip through its agency, as well as seven of the injured.

Turkish newspapers printed words of condolence in German.

"With you in our hearts," the Haber Turk newspaper read. "Your pain is our pain" Vatan newspaper said.


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The biggest selection of costumes in the world!

Adult Zombie Costume

Adult Zombie Costume
Adult Zombie Costume
Sale - Sale 13%
Select a Size
View Adult Plus Sizes
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Product Information
Items Included
  • Shirt
  • Pants
  • Pair of Gloves
  • Mask w/ Attached Wig
  • Cotton blue shirt and grey pants w/ shredded look
  • Sewn-in body parts over the chest, arms and thighs
  • Shirt Velcros in the back of the neck
  • Elastic waistband pants
  • Zombie character mask w/ attached hair
  • Zombie Men's Costume
Product Description

If you look out your front window one morning and see herds of zombies staggering around, you have two options. 1: make a break for it and eventually get horrifically eaten, or 2: join them. It may not be the most heroic choice, but this super-creepy Zombie Costume makes it pretty easy, and it definitely beats being eaten!

We know you're thinking, "No! You need to grab a shotgun, tie a dirty bandanna around your head, and fight for humanity!" To which we respond, "Come on, man, they're zombies." Every zombie movie shows flocks of survivors fleeing frantically at the sight of an undead horde, while a few brave souls band together to make a final stand, and promptly get eaten for their trouble. But people rarely try just teaming up with the shambling ghouls and seeing where it goes! Maybe after all the humans are eaten or turned into dead-heads themselves, the zombies just go back to what they were doing before they were zombified. And if that's the case, you would be totally free to return home and go back to bed! They never show that part in the movies, though, do they?

Well, okay, maybe being a zombie would be better without all the decomposition and people-eating. But this freaky full body costume lets you look like a reanimated corpse without all the gross stuff. The shirt and pants look like tattered clothes with exposed bones and organs attached, which go perfectly with the gruesome gloves and zombie mask. You may not like the undead apocalypse as a human, but in this costume, you can at least enjoy it as a zombie!

Size Chart
Size Measurement Standard Metric
Small Chest 44" 112cm
Small Shirt Length 28" 71cm
Small Waist 22" - 30" 56cm - 76cm
Small Pant Length 40" 102cm
Medium Chest 48" 122cm
Medium Shirt Length 31" 79cm
Medium Waist 28" - 38" 71cm - 97cm
Medium Pant Length 45" 114cm
Standard Chest 51" 130cm
Standard Shirt Length 28" 71cm
Standard Waist 26" - 42" 66cm - 107cm
Standard Pant Length 42" 107cm
Product Reviews Write A Review

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• Public Education Event

    Wednesday, January 23 2019
    12:30 p.m. - 1:10 p.m.
    McMaster Student Centre - Room 311
    (1280 Main Street West, Hamilton)

    Read more

  • 17th Annual Estates & Trusts Seminar

    Wednesday, February 6th 2019
    1:00 p.m. - 4:00 p.m.
    The Hamilton Convention Centre
    (1 Summers Lane, Hamilton)

    Read more

  • 14th Annual Commercial Litigation Law Seminar

    Wednesday, March 6th 2019
    9:00 a.m. - 1:45 p.m.
    Sheraton Hamilton Hotel - East Ballroom
    (116 King Street West, Hamilton)

    Read more

  • Looking for a Lawyer in Hamilton?

    Search our Membership Directory by:
    First & Last Name
    Area of Law
    LSUC Certified Specialist
    Language other than English

    Read more

  • Looking for a legal job in Hamilton?

    Search our Careers Page for:
    Jobs for Lawyers & Support Staff
    Seeking jobs for Lawyers & Support Staff
    Seeking jobs for Articling & Summer Students
    Seeking Volunteer Positions

    Read more

December 24th - 8:30 a.m. - 1:00 p.m
December 25th - CLOSED
December 26th - CLOSED
December 27th - 8:30 a.m. - 5:00 p.m.
December 28th - 8:30 a.m. - 5:00 p.m.
December 31st - 8:30 a.m. - 1:00 p.m.
January 1st - CLOSED

Message from the President

This is my fourth infomercial to the members of the HLA. I have just returned from the HLA sponsored tour to Peru that focused on Machu Picchu and the Amazon. It was a great vacation with some interesting and informative CPD, as well as good friendship and camaraderie. Stay tuned as to whether the Trustees decide to continue with HLA trips in 2020 and, if so, where. My personal thought is to plan for a shorter time away that is a bit cheaper, which would cater more to the younger lawyers. We will see. CONTINUE READING

W Patric Mackesy, President 2018-2019

The Hamilton Law Association

The Association’s affairs are governed by trustees and officers who ensure that Association undertakings are within the mandate and in the best interests of our legal community. The many valued volunteers who are members of the numerous committees within the structure of the HLA strive to represent our membership consistently and effectively. The Anthony Pepe Memorial Law Library, operated within the scope of the HLA, is one of the largest law libraries in Ontario and houses over 30,000 volumes.

The Hamilton Law Association continues to strive to educate and support its membership in the practice of law as well as to advocate for their interests as lawyers...

The staff of the Hamilton Law Association (HLA) Library cannot provide legal advice or research to members of the public directly. The HLA Library is a private library for the use of its members, and members of the Law Society of Upper Canada only. For information on finding legal help in Ontario please try the Bora Laskin Law Library's Guide to Finding Legal Help in Ontario, or to search for a lawyer practising in the Hamilton area try the HLA Find a Lawyer page.

This Web site is not intended to provide legal advice. It is intended to supply general information to our members. The information contained and distributed on this site does not contain any legal opinions and does not necessarily reflect the opinions of the Hamilton Law Association.

Please send comments and suggestions to our Webmaster:

Marica Piedigrossi, Executive Assistant & Social Media Coordinator

Tel: 905-522-1563
Fax: 905-572-1188
Email: mpiedigrossi@hamiltonlaw.on.ca

Rehab First (2)

Advertise Here
*SAVE 17% for a One-Year Commitment!*

Are you looking for a new place to advertise your business?
Why not advertise on the new and improved HLA Website?
DOWNLOAD the 2019 Online Advertising Information Package
Please contact Marica Piedigrossi at
for more information.


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Experience - So What?

We have been around, we claim we have seen and done it all. “Hire us. We have experience.” Really? Is this the pitch to get the next project or win that big project you and all your competitors are vying to win?

Don’t we really want to say, “We have highly educated staff keenly trained to quickly identify problems and offer the optimum solutions to save our customers money and even more precious, their time.” The rebuttal may be, “What makes your staff so special?” Now were getting to the nitty gritty. Are we special and unique because we have graduates from good schools-maybe? Are we different because we have been practicing for decades-perhaps? Or are we the engineers you want to hire because you know you are going to get your own special project manager and support team focusing on the success of your project, champion your cause to build a great project, and meet all those volleys of regulations and permits. Is it because in our firm you find a considerate caring professional to explain the process and solutions needed for your unique situation?

You want to hire us because you know it will be well designed and approved on time and budget but also because you will be kept informed as your project progresses; because you won’t have to ask yourself, “Is anything being done? Are they on schedule? Did I ask them to do what I really needed? Or, do I need something I didn’t think about?” You won’t be talking to yourself at bedtime because you know you hired Hammontree and those are the questions Hammontree’ s champions ask themselves. This is the experience we are offering. Our experience is how we care and become more involved in your project than the other firm down the street. Now that’s experience I like to buy. How about you?

Winter 2017-2018 - The Great Slaughter

Well, here we are again winding up another year. Like any business owner I've been busy closing out the final tallies of our finances, pension plans, and doing all those things required of a successful business. Then I got it, that rare moment where I am granted an unexpected breather and for the moment all the ducks are in a row.

Spring 2017

In the Spring of 2016 we shared the news of our investment in surveying and inspecting with Unmanned Aerial Vehicles (UAVs). Since then we have added more drones to our fleet and now boast three FAA certified drone pilots.


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90. Xiaoli Peng

90. Xiaoli Peng
  • Office Location: 1002 Raintree Circle, Ste 100, Allen TX 75013
  • Office Phone: 972-747-5100

Xiaoli Peng, has more than 20 years of professional experience in the real estate industry in China. She worked with the developers in the early stages of projects to obtain the pre-planning of the land, and in the mid-term cooperated with the product design of the architectural design institute, and then worked for the project planning and sales. Nearly ten million square feet of homes had been sold by her for countless developers. She had also brought better market products to more independent customers and investment clients. She has now moved to Dallas, the most promising city in the real estate market in the United States. Since she is familiar with Chinese citizen’s preference for both primary and investment residences, and has many years of real estate experience, plus the popularity of overseas properties for Chinese citizen, she will be able to bring high-quality properties resources overseas, and be a bridge connecting the company and investors.

China Real Estate Marketing Planner

Chengdu Real Estate Marketing Association

Keller Williams Realty Allen

(214) 326-5903

1002 Raintree Circle, Ste 100, Allen, Texas 75013


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Basket Classes at Swan Bay Folk Art Center

Basket classes are offered on Tuesday or Friday Evenings at 7:00 pm at Swan Bay Folk Art Center.  We have two varieties of classes to offer:

Tuesday Evenings:

Tuesday nights are open to anyone  You may pick a basket that you would like to make from the description of baskets and then select a date.

You must sign up for the basket you choose to make in advance (so we can get all the supplies cut and ready.) Please fill out the contact form or call Niki at (609)652-0366. Niki will notify you only if the class is full. Otherwise come and enjoy watching many different creations happen before your eyes!

Friday Evenings:

Friday nights are reserved for Friday Night Friendship Classes where you and 5 or more friends (up to 10 people) can enjoy an evening of basket making just for you and your party. You may choose any baskets from this schedule and have an enjoyable productive evening with your friends, colleagues, members from your church, bridal party, or anyone you choose!

***New in 2017***** At all Friday Night Friendship classes homemade treats, water and tea will be served.

Please call me to reserve your space as soon as possible as class dates fill up quickly.

Saturday Mornings:

Please see our SCOSA schedule for all available Saturday classes.

  ***  All of these classes will be take place at Swan Bay Folk Art Center.***


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A Hanover member of staff taking a call at her computer

General help & advice

General help & advice

Renting a home

We have 630 estates throughout England. We have no estates in Scotland, and only one estate in Wales.

Retirement Housing is a truly flexible option that provides independent living in your own one or two bedroom property. Find out more, including how to apply, in our Retirement Housing section.

Extra Care Housing might be more suitable for you if you need a little more support to live independently. Find out more, including how to apply, in our Extra Care Housing section.

There's a lot to think about and plan if you're considering moving into Retirement Housing or Extra Care Housing at Hanover. Please visit our How to apply for Retirement Housing and How to apply for Extra Care Housing pages for details.

You can also contact our Lettings Team on freephone* 0800 2802575. They will be able to talk you through the process and answer any questions you have.
*Calls are free from landlines but you may be charged if you call from a mobile, depending on your call plan.

Buying a home

We have 630 estates throughout England. We have no estates in Scotland, and only one estate in Wales.

At present we are unable to offer a service to market such properties on behalf of leaseholders and/or freeholders. On our website we provide listings by region so that those interested in buying a property from a Hanover homeowner can find out which estates have these types of property. They can then contact their local estate agent or search property websites for resales availability. To find out more, please visit our Buy a home page.

In most cases they can. The person living there has to comply with the age restriction in the lease but their family can buy and sign a Deed of Non Occupation.

In most cases the lease stipulates that the property must be your main residence.

This will depend on the terms of your lease.

Property prices vary depending on size, location and number of bedrooms. Where Hanover is actively selling properties, guide prices will be available. Any resales properties will be listed locally with estate agents - please visit our Buy a home section for further information.

Shared ownership is a way to buy a proportion of a property - typically 50% or 75% - and pay rent on the remaining unowned equity that remains with Hanover. You do not share the property with anyone else and you live in the property like any other sales property. You are simply buying the share you can afford. We have a small number of estates with shared ownership properties. Please contact our Sales Services team on 01480 223179 or via email to sales.services@hanover.org.uk for more information.

Tenants & homeowners

Our Rent, service and support charges page has lots of useful information on this topic.

Please see our Rent, service & support charges page for full details about the payment methods you can use as a tenant.

If you're having difficulties, or need advice about your payments, please see visit our Rent, service & support charges page. For payment enquiries, please contact our Income Management team on 0330 131 9837 (local network charges apply) or via email to income@hanover.org.uk.

Please visit our Repairs & making changes to your home page.

It may be possible for you to move from your existing Hanover property to a different Hanover property. Please see our Tenants section for more information.

This must be done by writing us a letter or completing our Ending a Tenancy form. Full details can be found on our Ending your Hanover tenancy page.

Our Ending your Hanover tenancy page provides details of what to do in the upsetting event of a tenant passing away.

Please visit our Homeowners section for lots of helpful advice.

If you're having problems paying your service charges, please visit our How to pay your service charges page.

Nearly all leases allow you to sell your home on to another private individual with our approval. However, you should let us know if you're intending to sell your home. Please visit our Selling your Hanover home page for full details.

Hanover on Call can take repairs calls but only if you don’t have an estate manager on site. If you do have an estate manager, please report the repair through them.

Our policy is that pulling your cord is free of charge. If you wish to call Hanover on Call instead, we have kept the cost to only 5p per minute.

We take fire safety very seriously and have robust fire procedures in place across all of its estates. For further information, visit our Health & safety page.

By phoning 01274 302070 or via email to complaints@hanover.org.uk.

Our vacancies are advertised on our website and update weekly. Please visit our Vacancies section to find out more.

We have guidance notes to help you through the application process. If you're having problems applying for a vacancy online, please contact our HR Shared Services team on 01480 224787 or via email.

Please contact the HR Shared Services team either by email to hr@hanover.org.uk or by phoning 01480 224787. Guidance notes can be found on our website which will help you through the application process.

Our employees are important to us which is why we offer a range of benefits from fantastic learning opportunities to a generous annual leave entitlement. Find out more on our Benefits & rewards page.

We welcome applications from people with a wide range of experience. You do not need to have housing experience to be an estate manager at Hanover as we will provide a full training programme for you. More important are your life skills, friendly, patient and calm manner and an ability to work with a wide range of people. You will also need sound administration and PC skills. More information about what is expected of an estate manager and the training we provide can found on our Estate Manager role page.

The first thing to do is log into your rEcruit account. Click on 'My Application' to view the applications you've submitted. You'll also be able to see the status of these applications.

We take our responsibilities seriously when handling people's data. Please ensure that you read our Privacy notice for staff and applicants, which explains how we use your data.


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Megan Rasmussen

This year’s recipient of the Hansen Injury Law Scholarship is Megan Rasmussen from Millard High School in Fillmore, Utah! In 2017, at the beginning of her senior year, Megan was in a car accident that resulted in several injuries, broken bones, and some severe permanent side effects. Despite the immense physical pain she had to endure, and especially the brain injury that impaired her ability to focus and think clearly, Megan was determined to not let this challenge affect her education. She finished high school with a flawless transcript and a 4.0 GPA, and is very deserving of this scholarship.

Megan will start her undergraduate education at Snow College in Ephraim, Utah.

We Might Be Able To Help You

We wish we could award everyone, and although that is not possible, we might be able to help you receive compensation for your accident and injury. If you were injured because of someone else’s negligence, we recommend taking this one minute quiz that will give you an idea if you could pursue an insurance settlement for your injury. We are also available on the phone to answer any questions you might have concerning your personal injury case.

You could be entitled to compensation for your injury:


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Titanium Gr5

UNS R65400, W.Nr. 3.7164

Titanium Alloy Gr 5 Ti6Al4V (Ti64) is the most widely used titanium alloy which is also heat treatable. Its high strength, low weight and corrosion resistance gives broad applications.The largest market for titanium Grade 5 is the airline industry. The alloy can by heat treatment, providing even greater strength. In addition to the aerospace industry the alloy is used for medical, chemical process equipment, automotive and marine applications.

Recommended filler metal for welding is Titanium AWS A5.16-90 ERTi-5.

Last updated Tuesday, August 16, 2016 2:10 PM

Check current stock status


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Shop the Street Style Look: School Girl Chic

Proving that layering need not require the skills of a seasoned stylist, the blogger behind Gary Pepper Vintage alters the vibe of her long-sleeve mini from simple dress to school-girl chic with one Peter Pan collar. Adding another element is her high-on-sex-appeal bootie-sandal hybrid. Get inspired by the unexpected and shop the look below.

Clockwise from left: Issa dress, $570, Carven blouse, $302, Azzedine Alaia shoes, $1588, Valentino bag, $1895, Guerlain liquid eye liner, $36.

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Junior-Mid C# Developer

Junior - Mid C# Developer

Hedgefund - £50,000-£60,000

C#, .Net, SQL, Angular, Oracle, SQL Server, Javascript

Harrington Starr is currently looking for a Junior- Mid level C# SQL Developer who has a keen interest within the buy-side (Hedge funds) to join a global partner of ours.

Skills & Experience:

  • Bachelor's degree in computer science or IT related field or equivalent work experience;
  • Team player with Good communication skills and Analytical;
  • Self-motivated with ability to work independently;
  • Discretion in handling confidential or sensitive information;
  •  2-4 years C# programming experience;
  • Strong SQL database development experience;
  • Good understanding of object-oriented design principles and design patterns;
  • Unit and Integration testing;
  • Agile development methodology;
  • Knowledge of HTML, CSS, JavaScript, Angular2, Type Script, jQuery
  •  Persistent/Real-time messaging system experience.

Candidate will work with business areas to design, build and deploy custom applications and enrich off-the-shelf applications as required;

  •  Provide technical solutions through development to automate processes or functions to improve business operations;
  • Develop corresponding operations and support procedures for application support
  •  Design and develop scripts to automate operational tasks and maintenance;
  • Administer and enforce IT development standards and processes;
  • Provide support during scheduled contingency tests and upgrades;
  • Assist with the installation of patches and updates, determine impact on applications;
  • Work directly with end users & support staff on issues.


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Potentially deadly 'thunder fever' set to hit Yorkshire this weekend

An urgent warning has been issued to Yorkshire asthma fever sufferers after experts predicted a risk of the potentially deadly 'thunder fever' over the coming days.

READ: How to spot if your baby is developing hay fever - and how to relieve it

'Thunder fever' set for Yorkshire'TOP PIC: PA'BOTTOM LEFT: Andrew Manning

'Thunder fever' set for Yorkshire'TOP PIC: PA'BOTTOM LEFT: Andrew Manning

There will be a risk of what is known as 'thunder fever', a potentially deadly cocktail of a combination of heavy thunderstorms and a high pollen count.

It is reported that last year the coming together of the two, which has been coined 'thunder fever', killed nine people in Melbourne, Australia.

READ: Drinking gin and tonic could help reduce hay fever symptoms

Heavy thunderstorms have been predicted over the UK from Saturday to Monday and Yorkshire has been warned of a high pollen count this weekend

How to relieve hay fever symptoms

With the high pollen count that is forecast for this weekend, hay fever sufferers will also find the weather conditions difficult.

Here are some top tips for keeping your symptoms down to a minimum.

- Keep windows closed when at home and overnight. Most pollen is released in the early morning and falls to ground level in the evenings when the air cools.

- When outdoors, wear sunglasses to keep pollen out of your eyes. Hay fever sufferers can experience itchy eyes when coming into contact with pollen spores. It is recommended that for any outdoor tasks, such as gardening, hay fever sufferers should wear a mask.

- Avoid drying your clothes outside when pollen counts are high. If you do, shake items before bringing them inside.

- Keep car windows closed when driving and fit a pollen filter to reduce the impact of pollen spores.

What is a high pollen count - and how do you relieve hay fever symptoms?

- When indoors, there are a number of useful tips to reduce the impact of hay fever symptoms such as: vacuuming regularly, avoid bringing fresh flowers indoors, and be aware that pets can bring pollen in on their fur.

- Don't allow smoking in the house as this will irritate the lining of your nose, eyes, throat and airways, making your hay fever symptoms worse.

- After being outside, shower and wash your hair to remove pollen.


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Carrie Bradshaw’s Apartment!

If you’ve ever wondered how many steps it took Carrie to get from her front door to her walk-in wardrobe, then wonder no more. Artist Nikneuk has re-created Ms Bradshaw’s apartment in sketch form, showing how much space she really had for all those designer stilettos. I’m not gonna lie, this is basically my ideal apartment (even more if the shoes came with it) so seeing it in this form is pretty special. As a massive Sex and the City fan this is a little piece of telly history that put a massive smile on my face… How she could ever move out and move into Big’s place is beyond me. I love all the detail and the fact that you can see how the rooms connect (who knew her kitchen was that big when she basically stored bags in the cupboard!) The most interesting fact is that this apartment would be worth around $10million today – there’s no way that Carrie would be able to afford it, even while writing that column at Vogue. Oh, how I miss SATC and the fantasy that came with it.

See more of these awesome floorplans here.

  1. Lula Belle
    September 2, 2012 / 1:00 pm

    I miss SATC too! What a brilliant sketch.

  2. kate
    September 2, 2012 / 1:03 pm

    I always loved her apartment, especially the little book alcoves next to the kitchen.

  3. Lauren
    September 2, 2012 / 1:39 pm

    I was expecting a bigger flat, and bigger closetLauren,Laurensbeautydepartment.blogspot.comxx

  4. Sheree Milli
    September 2, 2012 / 3:45 pm

    MY DREAM APARTMENT. Actually… FLAT… I'm English! x

  5. BeautyBecca
    September 3, 2012 / 7:01 am

    wow can't believe how much it would cost! if only….

Leave a Reply


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HCL Technologies

HCL Tech to add more than 1,000 employees in North Carolina office

Published Date:
Sep 18, 2014
Hindu Business Line

New Delhi, September 18:  Indian IT services companies are increasingly hiring closer to their clients. Noida-based HCL Technologies will be expanding its presence in North Carolina by hiring an additional 1,237 people by the end of 2018.

HCL Tech said it will invest around $9 million in expanding the centre.

The project is being done in part by a performance-based grant from the One North Carolina Fund of up to $123,700. The One NC Fund provides financial assistance, through local governments, to attract business projects that will stimulate economic activity and create new jobs in the state.

This is not the first time HCL Tech has invested in its global delivery footprint in order to enhance value for its clients by developing nearshore capabilities.

The company had earlier announced that it would be hiring 10,000 locals in the US by 2015. HCL in America is headquartered in Sunnyvale, California with more than 8,000 employees spread across 15 States in the US.

Global revenues

Its business in America contributes more than 50 per cent of HCL’s global revenues. The company has partnerships with North Carolina New Schools to leverage HCL’s services for content creation and management of its collaborative, online community.

“Given our core philosophy of building relationships beyond the contract, we remain committed to enhance our investments by developing nearshore capabilities in the communities we operate in,” Anant Gupta, CEO, HCL Technologies, said in a statement.

HCL will hire computer professionals to develop, maintain and upgrade software applications and provide services to global clients. Salaries will vary by job function and experience, but the average annual payroll is expected to be nearly $64 million, the company said. HCL is eligible to receive up to 12 annual grants equal to 75 per cent of the State personal income tax withholdings from the eligible new jobs created since the date of the initial award, it said. Over 12 years, this could yield aggregate benefits to HCL of more than $19.6 million upon the creation of 1,237 jobs.

Hindu Business Line
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Nigerian R&B/Soul singer Praiz has a new single out, featuring Burna Boy and rapper Ikechukwu. It’s called “69” and it’s about exactly what you think it is. At least the song sounds good, with Praiz producing the song himself and adding subtle guitars and sparse production that has all the peaks and valleys of a good Frank Ocean song. You can find Praiz over at X3M music.

Praiz: SoundCloud Twitter

Brady is the founder of Headphone Nation. He’s responsible for all this mess. Sorry about that. He’s also on Twitter @BradyWGerber

Also check out


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Eugene Kulaga

Eugene Kulaga

Dentistry  ·
Eugene Kulaga is a dentistry practitioner in Sarasota, FL and has been practicing for 35 years. He graduated from Georgetown University / School Of Dentistry in 1983 and practices dentistry, orthodontics, and more.Read his story

5899 Whitfield Ave Ste 105

Sarasota, FL 34243

Contact Information

Insurance Accepted

  • Aetna
  • Ameritas
  • Assurant Health
  • Delta Dental
  • Dental Network of America
  • DenteMax
  • Guardian
  • Humana
  • MetLife
  • 2 More

*Please verify this information when scheduling an appointment.

Background Check

No malpractice claims found for Florida
No disciplinary actions found for the years we collect data
No board actions found for the years we collect data
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Check if Eugene Kulaga treats your condition or procedure

Eugene Kulaga's conditions and procedures:

Alveolar Bone Loss
Ankylosis of Tooth
Bad Taste in Mouth
Black Hairy Tongue
Bonding Disorders
Bone Grafting
Bone Loss
Broken Tooth
Burning Mouth Syndrome
Cancer Screening
Canine Teeth, Absence Upper Permanent
Canker Sore
Ceramic Dental Braces
Ceramic Dental Crowns
Cerec® Tooth Restoration Procedure
Chipped Tooth
Chronic Periodontitis
Clear Ceramic Braces
Clear Dental Braces
Clear Retainer
ClearCorrect™ Invisible Braces
Clefting - Ectropion - Conical Teeth
Clicking of Temporomandibular Joint
Cold Sore
Complex Tooth Extraction
Composite Fillings
Computer Imaging for Dental Crowns
Conscious Sedation
Cosmetic Conditions
Cosmetic Contouring (Dental)
Cosmetic Oral Evaluation
Cosmetic Peridontal Problems
Craniofacial Disorders
Crown Lengthening
Deep Bleaching
Dental Bonding
Dental Bridge
Dental Bridge Adjustment
Dental Cleaning
Dental Crown
Dental Disorders
Dental Examination
Dental Filling
Dental Gum Flap Surgery
Dental Hygiene Services
Dental Imaging
Dental Implant
Dental Inlays
Dental Onlay
Dental Prophylaxis
Dental Prophylaxis, Adult
Dental Prophylaxis, Child
Dental Restoration
Dental Veneer
Dental X-Ray
Dentinogenesis Imperfecta
Dento Alveolar Surgery
Denture Repair
Device Implantation and Extraction
Diagnostic Imaging
Digital Impression System
Digital Tomography
Digital X-Ray (CDR)
Diode Laser Soft Tissue Treatment
Dry Mouth
Dry Tooth Socket
e.max® Dental Crowns
Edgewise Dental Braces
Endodontic Retreatment
Endodontic Surgery
Endodontic Treatment
Essix Retainer
Excessive Tooth Wear
Extraction of Wisdom Tooth
Facial Pain
Fixed Orthodontic Correction
Fluoride Treatment
Fluoride Varnish
Full Mouth Reconstruction
Gaps Between Teeth
Geographic Tongue
Glow in the Dark Dental Braces
Gold Dental Braces
Gold Dental Inlays
Grinding of Teeth
Gum Disease
Gum Disease Treatment
Gum Graft Surgery
Gum Surgery
Hawley Retainer
i-CAT® 3D Dental Imaging
Impacted Teeth
Implant-Supported Bridge
Implant-Supported Crown
Implant-Supported Dentures
Intraoral Camera
Invisalign® Consultation
Invisalign® Impression
Invisible Dental Braces
Jaw Bone Tissue Deterioration
Jaw Implant Surgery
Jaw Misalignment Leading to TMJ
Jaw Sprain
KöR Whitening Deep Bleaching™
Laser Assisted Periodontal Therapy
Laser Cavity Detection
Laser Lingual Frenectomy
Laser Maxillary Frenectomy
Laser Microsurgery
Laser Office Procedure
Lesion Removal
Light Activated Teeth Whitening
Limited Gum Surgery
Loose Teeth
Lower Dentures
Malocclusion (Bad Bite)
MDI Mini Dental Implant
Metal Dental Braces
Microscope-Aided Endodontic Treatment
Microsonic Dental Cleanings
Microsurgical Procedure
Misaligned Teeth
Misshapen Teeth
Molar Endodontics
Mouth Conditions
Mouth Lesions
Mouth Ulcer
Nitrous Oxide Administration
Nitrous Oxide Sedation
Non-Surgical Bite Correction
Non-Surgical Gum Treatment
Non-Surgical Orthodontic Procedures
Oral Infection
Oral Lichenoid Lesions
Panoramic and Cephalometric Digital Dental X-Rays
Panorex FMX
Pediatric Dental Exam
Periodontal Exam
Permanent Retainer
Pocket Depth Measurement
Porcelain Dental Inlays
Porcelain Dental Onlays
Porcelain Fixed Bridges
Porcelain Veneers
Post-Operative Care
Postoperative Pain
Power Teeth Whitening
Preseason Dental Exam
Propel® Orthodontics
Prophy Jet Air Polishing
Receding Gums
Removable Appliances
Removal of Bone Spur
Restoration of Dental Implants
Retainer Therapy
Root Canal
Root Planing
Rotary Endodontics
Same-Day Dental Onlays
Scaling and Root Planing
Sedation Endodontics
Sensitive Teeth
Simple Tooth Extractions
Single Visit Root Canals
Sinus Augmentation
Six Month Smiles
Sleep Apnea Oral Appliances
Smile Makeovers
Snoring Prevention
Soft Tissue Infection
Stained Teeth
Swollen Gums
Teeth Extraction
Teeth Noneruption With Maxillary Hypoplasia and Genu Valgum
Teeth Polishing
Teeth Scaling
Teeth Whitening
Tempormandibular Joint Pain
Temporomandibular Ankylosis
Tender Gums
Tongue Conditions
Tooth Abnormalities as Seen in Diabetes
Tooth Abrasion
Tooth Abscess
Tooth Attrition
Tooth Damage
Tooth Decay
Tooth Decay Caused by Acid Attack
Tooth Demineralization
Tooth Discoloration
Tooth Discoloration (Resistant to Whitening)
Tooth Displacement
Tooth Loss
Tooth Preparation for Dental Crown
Tooth Replant
Tooth-Borne Denture
Tooth-Conserving Dentistry
Traumatic Dental Injury Treatment
Ultrasonic Dental Cleaning
Upper Dentures

About Me

Care Philosophy

At The Smile Centre, our mission is to provide you with the highest levels of comprehensive and cosmetic private dental care focusing on true overall health.  With a genuine interest in each individual guest, we have been happily serving the ...

Practice Areas

  • Dentistry
  • Cosmetic Dentistry
  • Craniofacial Orthodontics
  • Emergency Dentistry

  • American Academy For Functional Orthodontics
    Fellowship Hospital
  • 2009
    University Of Medicine and Dentistry Of New Jersey
    Fellowship Hospital
  • 2007
    American Academy Of Pain Management
    Fellowship Hospital
  • 2006
    American Academy Of Craniofacial Pain
    Fellowship Hospital
  • 2004
    Fellow Academy Of General Dentistry
    Fellowship Hospital
  • 1983
    Georgetown University / School Of Dentistry
    Medical School
  • 1977
    Seton Hall
    Undergraduate School

Eugene Kulaga's Reviews

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Eugene Kulaga's Performance
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  • Answers questions
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What People Say About Eugene Kulaga
RecentMost Helpful
Dr. Kulaga and his entire staff are amazing professionals! Having dental work done is something I dread, and my experience at the Smile Centre in Sarasota has changed how I feel about dental work. Dr. Kulaga provided me with excellent and complete information about several issues. My experience...Read More
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Most caring, ethical, smart and professional dentist! Takes the time to listen and very gentle! Has an amazing ability to put you at ease! Highly recommend this dentist!
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Dr. Kulaga is a rockstar. Visit him for any of your orthodontic needs.
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Dr Kulaga just put braces on two of my children. He and his staff were very patient and accomodating. We look forward to better smiles w Dr Kulaga
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Great personality! Dr. Kulaga was great. He took his time explaining things to me...which was helpful because some of the issues I had been experiencing for many years and didn't know they were related to my teeth.
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The Smile Centre, Sarasota, FL

  • Call
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  • Hours
    • Mon: 9:00am - 5:00pm
    • Tue: 9:00am - 5:00pm
    • Wed: 9:00am - 5:00pm
    • Thu: 9:00am - 5:00pm
    • Fri: 9:00am - 5:00pm
    • Sat: closed
    • Sun: closed
  • Directions
  • Call
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  • Hours
    • Mon: 9:00am - 5:00pm
    • Tue: 9:00am - 5:00pm
    • Wed: 9:00am - 5:00pm
    • Thu: 9:00am - 5:00pm
    • Fri: 9:00am - 5:00pm
    • Sat: closed
    • Sun: closed
  • Directions
  • Call
  • Fax
  • Hours
    • Mon: 9:00am - 5:00pm
    • Tue: 9:00am - 5:00pm
    • Wed: 9:00am - 5:00pm
    • Thu: 9:00am - 5:00pm
    • Fri: 9:00am - 5:00pm
    • Sat: closed
    • Sun: closed
  • Directions

Insurance accepted

Accepted insurance can change. Please double-check when making an appointment.

Dental DPPO
Dental Maintenance Organization DMO
Ameritas PPO
Assurant Health
DHA Premier
Delta Dental
Delta Dental PPO
Delta Dental Premier
Dental Network of America
Dental Network of America DPPO
DentalGuard Preferred
Humana PPO
MetLife PDP
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Moles are colored spots or bumps of various shapes and sizes on your skin. They form when pigmented cells called melanocytes cluster together.

Moles are very common. Most adults have between 10 and 40 of them on various parts of their body. Moles are most likely to form on areas of skin that have been exposed to the sun. You’re more likely to get moles if you’re fair skinned and often in the sun.

The majority of moles are harmless. These are called common moles. They rarely turn into cancer, unless you have more than 50 of them.

Less common are atypical moles (dysplastic nevi). These moles aren’t cancerous, but they can turn into cancer. About 1 out of every 10 Americans has at least one atypical mole. The more of these moles you have, the greater your risk of developing melanoma — the deadliest type of skin cancer. Having 10 or more atypical moles increases your risk 14-fold.

Because an atypical mole has the potential to turn into melanoma, knowing which type you have and watching for any changes can help you get an early diagnosis if it is cancer. Experts suggest that you do monthly skin self-exams, checking your entire body — including less obvious areas like the soles of your feet, your scalp, and the skin underneath your fingernails — for any new or changing growths.

What does a typical mole look like?

A mole can be a flat spot or large bump. Normal, common moles have these characteristics:

  • They are one color, such as brown, tan, red, pink, blue, clear, or skin-toned.
  • They measure less than 1/4 inch (5 millimeters) across.
  • They’re round and even on both sides.
  • They have a well-defined border that separates them from the rest of your skin.
  • They don’t change.

What does an atypical mole (dysplastic nevus) look like?

An atypical mole can form anywhere on your body, including your head, neck, scalp, and torso. They rarely appear on the face.

Atypical moles can also be flat or raised. They also have these characteristics:

  • They measure more than 1/4 inch (5 mm) across — larger than the size of a pencil eraser.
  • They are irregularly shaped, with uneven borders that may fade into the skin around the mole.
  • They contain more than one color, including a mixture of brown, black, tan, pink, and white.
  • Their surface may be smooth, rough, scaly, or bumpy.

What to do if you have atypical moles

Examine your skin once a month in front of a full-length mirror. Check every part of your body, including:

  • your scalp
  • the backs of your arms
  • your palms
  • the soles of your feet
  • in between your fingers and toes
  • the back of your neck
  • behind your ears
  • between your buttocks

If you can’t see all of these areas yourself, ask someone to help you look. Keep a record of any new spots, and check them often to see if they’re changing. If you have atypical moles, you should also see your dermatologist for checkups every six months to one year.

Any new, suspicious-looking, or changing spots should prompt an immediate visit to your dermatologist. Although most atypical moles never turn into cancer, some of them can. If you do have melanoma, you want to have it diagnosed and treated early, before it has a chance to spread.

Your doctor will examine your moles. He or she will probably take a sample of tissue from one or more of the moles. This test is called a biopsy. The sample will go to a laboratory, where a specialist called a pathologist will check to see if it’s cancer.

If your dermatologist finds that you have melanoma, your close family members should probably get checked, too.


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Wednesday, August 1, 2018

Daily Blog #440: Windows 10 Notifications Database

Hello Reader,
       I had stopped thinking about the Windows 10 notifications database since I last saw Yogesh Kahtri blog post about it here. I was reviewing a file list produced by an opposing party in a litigation we are working and suddenly saw a directory full of notification images and got curious again.

Since Yogesh first blogged about it the location of the Notification data has changed and it is now located here:

Pictures pushed to the system and displayed in start menu tiles or notifications are stored here:

And the database is now a SQLite database named wpndatabase.db which you can open up with any SQLite tool. I am using Navicat for SQLite because its one of my favorites.

When I did I found the database I went looking to see which table contained the data that I would think is interesting and found a table named Notification, here is the schema:

There are three fields here you should pay attention to the first is the HandlerID which will tell you which program created the notification, you find the name associated in the NotificationHandler table.

The second field is the Payload field, this is the actual contents of the Notification, I was looking through here to see if there was something interesting and found all the Notifications that Outlook had been popping up as I was getting new emails. Here is an example:

Placeholder image
Caesars Total Rewards
Win big in August with the play by TR app! Download now!
Download and log in to be rewarded.         View this email with images. <

Within the text tags you can see the contents of the new mail notification I received from Outlook.

 The last fields to look at are the ExpiryTime and ArrivalTime which record when the notification was received (ArrivalTime) and when it will be deleted from the database (ExpiryTime). These are stored in decimal but if you convert them to Hex you can convert them back to a readable time using the Windows FileTime BigEndian option in Dcode.

So there you go, we can recover the sender, subject and first lines of an email in the notification database even if the email has been purged from the system otherwise. I am going to look further into this to see if there is any other Notifications of interest.

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Saatchi Gallery NEWSPEAK and Dinesen Floors

I recently went to an exhibition at the Saatchi Gallery Newspeak: British Art Now Part II.  Aimed at giving an insight into the art being made in the UK today, the new YBA’s as it were.  I always like a gallery, museum or historical building to have a mooch and gain inspiration. Whilst the art was the reason for going to the Saatchi I have to say the building alone is worth a visit.

The Saatchi Gallery is in the listed Duke of York’s HQ building in Chelsea with over 67,000 sq ft of gallery space most of which is contained in the original classical Victorian building.  The gallery has clear and simple interior spaces so that the art is the focus.  With an ERCO lighting scheme based on stretched fabric light boxes the gallery spaces are fantastically evenly lit.  In some rooms the ceiling heights are over 4m, completely jaw dropping.  With a neutral palette throughout white walls are stripped of all detail such as door architraves, mouldings and skirting boards.

Floor to ceiling openings some with pivoting doors create interesting vistas between the white spaces. However it’s the floors that are the scene-stealers, from Dinesen the distinctive wide timber floor planks are 450mm wide and span the full width of the gallery and are finished in a white stain.  I want to use them so badly but so far no project has had the scope, but one day I am going to use this beautiful and elegant product.

As for the art, Jonathan Wateridge’s ‘Space Program’, the Loved Untitled sculpture by Marcus Foster and Richard Wilson’s 20:50 were my favourites.  Wateridge’s  blown up photograph felt like something I might have seen a magazine.

Foster’s sculpture standing at nearly 2.5 metres tall, made from steel and painted in a blue tone called to me.

Wilson’s 20:50 takes its name from the type of recycled engine oil used. Look at those sharp edges…

  1. April 6, 2011 / 12:39 pm

    A very lovely space – much nicer than when it was at the Town Hall I think!

  2. April 6, 2011 / 2:23 pm

    It's so lovely and like I say the floors are heavenly. Its interesting looking back at my photo'd though as I hadn't noticed the rosy tone whilst there.

    I did wonder what it would be like to ride a bike around 😉

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[email protected] +91 9175287066
This website is always under updation with new contents
Unit-I Architecture of 8086
Unit I
Unit II
Unit III
Unit IV
Unit V
Features of 8086 Microprocessor
• Intel 8086 was launched in 1978.
• It was the first 16-bit microprocessor.
• This microprocessor had major improvement over the execution speed of 8085.
• It is available as 40-pin Dual-Inline-Package (DIP).
• It is available in three versions:
o 8086 (5 MHz)
o 8086-2 (8 MHz)
o 8086-1 (10 MHz)
• It consists of 29,000 transistors.
The Block Diagram of 8086
The block diagram of 8086 is as shown below.
This can be subdivided into two parts namely - Bus Interface Unit and Execution Unit.
The Bus Interface Unit (BIU)
• The Bus Interface Unit consists of segment registers, adder to generate 20 bit physical address and instruction prefetch queue.
• The complete physical address which is 20 bits long is generated using 16 bit segment and offset registers using adder.
• In other words this unit is responsible for establishing communication with external devices and peripherals including memory via the bus.
• Once the physical address is sent out of BIU, the instruction and data bytes are fetched from memory and they stored into a First In First Out (FIFO) 6 byte queue.
• This Queue is 6 byte long used to store the op-codes fetched from memory in advance.
In short the function of BIU is to
• Fetch the instruction or data from memory.
• Write the data to memory.
• Write the data to the port.
• Read data from the port.
Function of Instruction Queue
1. To increase the execution speed, BIU fetches as many as six instruction bytes ahead to time from memory.
2. All six bytes are then held in first in first out 6 byte register called instruction queue.
3. Then all bytes have to be given to EU one by one.
4. This pre fetching operation of BIU may be in parallel with execution operation of EU, which improves the speed execution of the instruction.
Segment Registers
There are four different 64 KB segments for instructions (code), stack, data and extra data. To specify where in 1 MB of memory these 4 segments are located the processor uses four segment registers:
1. CS register: -
Code segment (CS) is a 16-bit register containing address of 64 KB segment with processor instructions. The processor uses CS segment for all accesses to instructions referenced by instruction pointer (IP) register.
2. SS Register: -
Stack segment (SS) is a 16-bit register containing address of 64KB segment with program stack. By default, the processor assumes that all data referenced by the stack pointer (SP) and base pointer (BP) registers are located in the stack segment.
3. DS register: -
Data segment (DS) is a 16-bit register containing address of 64KB segment with program data. By default, the processor assumes that all data referenced by general registers (AX, BX, CX, and DX) and index register (SI, DI) is located in the data segment.
4. ES register: -
Extra segment (ES) is a 16-bit register containing address of 64KB segment, usually with program data. By default, the processor assumes that the DI register references the ES segment in string manipulation instructions.
Instruction Pointer:
The Instruction Pointer or IP (also called the program counter in 8085) is a processor register that indicates where the computer is in its instruction sequence. In 8086 instruction pointer holds the address of the next instruction to be executed. In most processors, the instruction pointer is incremented automatically after fetching a program instruction, so that instructions are normally retrieved sequentially from memory, with certain instructions, such as branches, jumps and subroutine calls and returns, interrupting the sequence by placing a new value in the program counter.
Execution Unit (EU):
• The execution unit consists of registers such as 16-bit AX, BX, CX and DX and pointers like SP (Stack Pointer), BP (Base Pointer) and index registers such as SI (source index) and DI (destination index) registers.
• The 16-bit registers can be split into two 8-bit registers. For example, AX can be split into AH and AL registers.
• It has a 16 bit ALU (Arithmetic and Logical Unit), able to perform arithmetic and logical operations.
• It has a 16 bit flag register to reflect the results of execution by the ALU.
• The control system which is decoding section and timing and control unit decodes the op-codes and derives the necessary control signals to execute the instructions.
In short the functions of execution unit are
• To tell BIU where to fetch the instructions or data from.
• To decode the instructions.
• To execute the instructions.
Arithmetic Logic Unit (ALU):
Arithmetic logic unit (ALU) is a digital circuit that performs arithmetic and logical operations. The ALU is a fundamental building block of the central processing unit (CPU) of a computer, and even the simplest microprocessors contain one for purposes such as maintaining timers.
General Purpose Registers of 8086
These registers can be used as 8-bit registers individually or can be used as 16-bit in pair to have AX, BX, CX, and DX.
1. AX Register: AX register is also known as accumulator register that stores operands for arithmetic operation like divided, rotate.
2. BX Register: This register is mainly used as a base register. It holds the starting base location of a memory region within a data segment.
3. CX Register: It is defined as a counter. It is primarily used in loop instruction to store loop counter.
4. DX Register: DX register is used to contain I/O port address for I/O instruction
Flag Registers of 8086:
Flag register in EU is of 16-bit long and is shown in fig below
Flags Register determines the current state of the processor. They are modified automatically by CPU after mathematical operations, this allows to determine the type of the result, and to determine conditions to transfer control to other parts of the program. 8086 has 9 flags and they are divided into two categories: 1. Conditional Flags
2. Control Flags
Conditional Flags: -
Conditional flags represent result of last arithmetic or logical instruction executed.
Conditional flags are as follows:
• Carry Flag (CF): This flag indicates an overflow condition for unsigned integer arithmetic. It is also used in multiple-precision arithmetic.
• Auxiliary Flag (AF): If an operation performed in ALU generates a carry/barrow from lower nibble (i.e. D0 – D3) to upper nibble (i.e. D4 – D7), the AF flag is set i.e. carry given by D3 bit to D4 is AF flag. This is not a general-purpose flag; it is used internally by the processor to perform Binary to BCD conversion.
• Parity Flag (PF): This flag is used to indicate the parity of result. If lower order 8-bits of the result contains even number of 1’s, the Parity Flag is set and for odd number of 1’s, the Parity Flag is reset.
• Zero Flag (ZF): It is set; if the result of arithmetic or logical operation is zero else it is reset.
• Sign Flag (SF): In sign magnitude format the sign of number is indicated by MSB bit. If the result of operation is negative, sign flag is set.
• Overflow Flag (OF): It occurs when signed numbers are added or subtracted. An OF indicates that the result has exceeded the capacity of machine.
Control Flags: -
Control flags are set or reset intentionally to control the operations of the execution unit. Control flags are as follows:
1. Trap Flag (TP):
a. It is used for single step control.
b. It allows user to execute one instruction of a program at a time for debugging.
c. When trap flag is set, program can be run in single step mode.
2. Interrupt Flag (IF):
a. It is an interrupt enable/disable flag.
b. If it is set, the maskable interrupt of 8086 is enabled and if it is reset, the interrupt is disabled.
c. It can be set by executing instruction sit and can be cleared by executing CLI instruction.
3. Direction Flag (DF):
a. It is used in string operation.
b. If it is set, string bytes are accessed from higher memory address to lower memory address.
c. When it is reset, the string bytes are accessed from lower memory address to higher memory address.
Base Pointer (BP):
Base Pointer is a 16-bit register pointing to data in stack segment. BP register is usually used for based, based indexed or register indirect addressing.
Source Index (SI):
Source Index is a 16-bit register. SI is used for indexed, based indexed and register indirect addressing, as well as a source data address in string manipulation instructions.
Destination Index (DI):
Destination Index is a 16-bit register. DI is used for indexed, based indexed and register indirect addressing, as well as a destination data address in string manipulation instructions.
Segmentation and Segment Registers:
8086 Address Space
• The 8086 processor has a 20-bit physical address to directly address 1M byte of memory.
• Word size is only 16 bits.
• 20-bit address is splitted in 16-bit segment address and 16-bit offset address.
Segment address shifted four bits to the left and added to the offset value to generate a 20-bit effective address. Effective address is expressed as a 5 digit hex value (00000h to FFFFFh)
Memory Segments
• A segment is a block of 64Kb consecutive memory bytes.
• Segments are identified by segment numbers 0 - FFFFh.
• A 16 byte block makes up a paragraph.
• Segments always start on paragraph boundaries.
• Least significant nibble of segment address will always be 0.
Segment Registers
CS, DS, SS, and ES always point to low address end of segment.
CS - Code Segment register - points to a segment containing code.
DS - Data Segment register - points to a segment containing data.
SS - Stack Segment Register - points to a segment containing stack.
ES - Extra Segment register - points to a segment containing data Address.
Program memory –
Program can be located anywhere in memory. Jump and call instructions can be used for short jumps within currently selected 64 KB code segment, as well as for far jumps anywhere within 1 MB of memory. All conditional jump instructions can be used to jump within approximately +127 - -127 bytes from current instruction.
Data memory –
The processor can access data in any one out of 4 available segments, which limits the size of accessible memory to 256 KB (if all four segments point to different 64 KB blocks). Accessing data from the Data, Code, Stack or Extra segments can be usually done by prefixing instructions with the DS:, CS:, SS: or ES: (some registers and instructions by default may use the ES or SS segments instead of DS segment). Word data can be located at odd or even byte boundaries. The processor uses two memory accesses to read 16-bit word located at odd byte boundaries. Reading word data from even byte boundaries requires only one memory access.
Stack memory can be placed anywhere in memory. The stack can be located at odd memory addresses, but it is not recommended for performance reasons (see "Data Memory" above).
Reserved locations:
• 0000h - 03FFh are reserved for interrupt vectors. Each interrupt vector is a 32-bit pointer in format segment: offset.
• FFFF0h - FFFFFh - after RESET the processor always starts program execution at the FFFF0h address.
The Arithmetic and Logic Unit adjacent to these registers perform all the operations. The results of these operations can affect the condition flags. Different registers and their operations are listed below:
Addressing mode
Addressing mode indicated a way of locating data or operands.depending upon datatypes used in the instruction and the memory addressing mods,any instruction may belong to any of the addressing mode.
There are seven different types of 8086 microprocessore.
1. register addressing mode
2. immediate addressing mode
3. direct addressing mode
4. register indirect addressing mode
5. base relative addressing mode
6. base relative addressing mode
7. index addressing mode
1. Register addressing mode:
In this addressing mode the data will transfer to another register.all the register except IP(instruction pointer) may be used in this addressing mode.
2. Immediate addressing mode:
In this type of addressing mode the immediate data is the part of instruction.
Ex:- MOV BX,2567 H
3. Direct addressing mode:
In the direct addressing mode 16-bit memory location (offset address)is directly specified in the instruction itself.
4. Register indirect addressing mode:
in this addressing mode the offset address of data is in either BX,SI or DI register.the default segment is either DS or ES.
Ex:- MOV AX,[BX]
5. Base plus index addressing mode:
In this addressing mode the effective address of data is formed by adding contents of the contents of the base register (BX or BP) to the contents of an index register,(SI or DI)
Ex:- MOV CX,[BP][SI]
6. Register relative addressing mode:
In this addressing mode the data is available on effective address formed by adding an 8-bit or 16-bit displacement with the contents of the any one of register.
Ex:-MOV CX,[BX] 08H
7. Base relative index addressing mode:
The effective address is formed by adding an 8 or 16-bit displacement with the some of contents of any one of the base register or any one of index register.
EX:-MOV CX,[BX][SI]2678H
8. Index addressing mode:
In this addressing mode the offset address of data is stored into the memory location addressing by index register.
Data instruction set:-
1. Data transfer group:-
• MOV Rd , Rs:
This instruction transfers the contents of source to destination.we can load any register by immediate 8-bit as well as 16-bit data also.
MOV AX,2567 H
This instruction transfers the contents of specified register into the stack memory.whenever PUSH AX will be decremented by one. And then stored AH will transfer to the memory location pointed by the stack pointer.
Then again stack pointer will be decremented by 1 and the contents of AL will transfer to memory location pointed by stack pointer(sp-2)
This instruction when executed it loads the specified registers/memory with the contents of effective address formed by segment (stack segment)and stack pointer.
When this instruction is executd the contents of memory location pointed by SS:SP transferred to the lower bit of specifid register,stack pointer will incremented by one and the contents of memory location SS:SP transferred to the higher bit of specified register.
This instruction exchange the contents of the specified source and destination which may be register or one of them may be a memory location.
X CHG BX,[5000]
This instruction is used to read an input port.the address of part may be directly or indirectly given by register.the inputed data will be store in either AL on AX register.
Ex:-MOV DL,08
IM 03 H
This instruction is used for writing the data to the output port.the address of output port may be specified instruction directly or indirectly by register.
Ex:- OUT 08,AL
MOV DX,0008H
• LEA (load effective address):
The load effective address instruction load the effective address formed by destination operand into the specified source register.this instruction is more useful for ALP rather than machine language programming.
Ex:- LEA DX,address
LEA DX,add[SI]
This PUSHF(push flag into stack) instruction pushes the flag register into the stack memory.first the upper byte and then lower byte pushed on it.
The POP flag instruction loads the flag register completely (both bytes) from the stack memory locatin address by SS:SP
2. Arithimatic group:
• Add:
This instruction adds the contents of immediate data.memory location or register to the contents of another register or memory location.the results will stored in the destination operands.
Both the operands should not be immediate as well as from the memory location.
Ex:- Add AX,BX
ADD DX,2878H
ADD CX,[6000H]
ADD 0123H
• ADC:
This instruction performs the add operation between source and destination operands with carry and result stored into the destination operand.all the conditional flag affected by this instruction.
ADC DX,2878 H
ADC CX,[6000H]
ADC ,0123 H
• INC:
This instruction increments the contents of specified register by 1.all the comditional flags are affected except carry flag.
• DEC:
This instruction decrements the contents of specified register or memory location.all the conditional flags are affected except the carry flag.
DEC [5000]
• SUB:
This instruction subtract the contents of source operand from destination operand and the result is stored on the destination operand.source operand may be register,memory location or immediate data and the destination operand may be register.memory location.but source and destination both should not be memory location or immediate data.all conditional flags are affected by this instruction.
Ex:-SUB AX ,2376H
SUB CX,[5000]
SUB [6000],0256H
This instruction compares source operand (register,immediate data,memory location)with destination operand(which may be a register or memory location).for comparision it subtracts the source operand from destination operand but doesn’t change the content of any one.all the conditional flags are affected by this instruction.
CMP BX,1026H
CMP DX,[6000H]
This instruction multiplication the byte or word by the contents of AL.the unsigned byte or word may be in any one of the general purpose register or memory location.
The most significant word of the result is stored into DX register while the least significant word of the result is stored into AX.
All the conditional flags are affected by this instruction.

• IMUL(signed multiplication):
This instruction multiplies the signed byte in source operands by a signed in AL or signed word in source operand by a sign word in AX.the source can be GPR.memory location or index/base register.the higher word of result stored into DX register and lower word of result is stored into AX register.

• DIV(Unsigned division):
This instruction performs unsigned division .it divides an unsigned word or double word by a 16-bit or 8-bit operand.the dividend must be in AX register for 16-bit operation and division will be specified using any of the addressing mode except immediate addressing mode.and the result will be in AL()while AH will content the (remender).
If the result is two big to fit into AL type O interrupt is generated (divide by zero).
In case of double word the higher word should be in DX and the lower word should be in AX.
3.logical group:-
• AND:
This instruction bit-by+bit ANDs the source operands by destination operands and result will be in destination operand.
AND AX,[5000]
• OR:
This instruction performs the OR operation between source and destination operands
OR AX,[5000]
OR [6000],DX
• NOT:
This instruction complements the given operand.the operand may be from any register,memory location.
This instruction performs the X-OR operation bit-by-bit and the result stored into destination.
XOR CX,2617H
XOR [2000],DX
This instruction shifts the contents of specified register towards left and insert the zero into the newely introduced LSB.it can sheft a word as well as a byte .it shifts one bit by default otherwise number of bits specified in the instruction.
Ex:-SHL AX,05H
This instruction shifts the contents of (byte or word)specified register towards right bydefaulty it will shift number of bits given by instruction itself.
This instruction shifts the contents of specified register towards right arithmeticly.if it is signed number then it will check MSB.if MSB is one the one will be placed at the newly introduced MSB.
Ex:- SAR BX,02H[BX=F27E]
1111 0010 0111 1110
1111 0010 0111 111
1111 0010 0111 11
• ROR(rotate right without carry):
This instruction rotates the contents of destination operand to the right(bitwise)either by 1 or number of bit specified by the instruction.
• ROL(rorate left without carry):
This instruction rotates the contents of destination operand to the left(birtwise)either by 1 nor number of bit specified by the instruction.
Ex:-ROL CX,06H
CF 0010 1010 1100 0011
O 1011 0000 1100 1010
• RCR(rotates right through carry):
This instruction rotates the contents of destination operand through carry(bitwise) by either 1 or number of bits specified by instruction.
Here LSB will transfer to carry flag and carry flag will transfer to MSB.
Ex:-RCR CX,06H
0010 1010 1100 0011
0001 1100 1010 1011
• RCL(rotate light through carry):
This instruction rotates the destination operand to left through carry (bitwise)by either or number of bits specified by instruction.
Ex:-RCL CX,06H
0010 1010 1100 0011
1011 0000 1110 0101
• REP(repeat instruction prifix):
This instruction repeats the instruction to which it is prefix to which it is prefix after each iteration the bydefault counter cx will be decremented or incremented by one or two (if word decremented by two and byte decremented by one).
This instruction transfers the byte or word (string) from DS:SI memory location to ES:DI memory location.
MOV AX,4000H
MOV AX,8000H
MOV AX,1000H
CLD(clear direction flag)
MOV CX,0005H
• CMPS(comparing two string):
This instruction compairs two string of byte or word.the length of the string must be stored into CX register.if both the byte or word are equal the zero flag is set otherwise reset.
The DS:SI and ES:DI points the two string.
MOV AX,4000
MOV AX,8000
MOV DI,1000H
MOV CX,0005H
If string are equal then CX=0 and Z=1
Otherwise Z=0
• SCAS(scan string):
This instruction scans a string of bytes or word for an operand byte or word specified in the AL or AX register .the length of the string is stored in CX register is pointed by ES:DI
MOV AX,4000
MOV DI,1000H
MOV CX,0005H
If the maching of word found then zero will be set otherwise reset.
• LODS(load string):
The lods instruction loads AL or AX register by the contents of a string pointed by DS:SI.the SI is modified according to direction flag(DF).
• STOS(store string):
The STOS instruction stores the contents of a AL?AX register to a memory location of string pointed by ES:DI
5. Branch instruction (control transfer):
The control transfer instruction transfer the flow of execution of the program to a new address specified in the instruction directly or indirectly.when this type of instruction is executed and CS and IP get loaded by new value of CS and IP
There are two types of branching instruction:-
1.unconditional branching
2.conditional branching instruction
a) unconditional branching instruction:
in this type of instruction the execution control is transferred to the specified location independent of any status or condition.
b) conditional branching instruction:
in this type of instruction,the control is transferred to the specified location,after satisfy the particular condition,otherwise the execution continue in normal flow sequence.
a) unconditional branching instruction:
This instruction is used to call a subroutine from a main program.the address of subroutine may be specified directly or indirectly.there are again two types of subroutine depending upon whether it is available in same segment.(NEAR CALL) or in another segment (far CALL).
On execution of this instruction,it stores the incremented IP and CS into the stack memory and loads the CS and IP with the subroutine to be called repectively.
In case of near CALL ,it pushes only IP register and in case of far CALL it pushes IP as well as CS
• RET(return):
at each CALL instruction the IP and CS of next instruction is pushed on the stack memory before the control is transferred to the subroutine the RET instruction must be executed.
When it is executed the previous stored contents of IP and CS along
with flag are retrived into the CS and IP
the subroutine may be far or near.in case of near subroutine only IP will be retrived,otherwise CS and IP both will be retrived.
• JMP(unconditional jump):
this instruction unconditionally transfer the control to the specified address using 8-bit or 16-bit displacement no flags are affected by this instruction.
this instruction executed the part of program from the lable or address specified by the instruction itself upto the loop instruction .this will execute repeatedly until the counter become zero.
Ex: MOV AX,2567 H
MOV CX,0005H
INT 21H • In the interrupt structure of 8086,256 intreeupt are defined corresponding to the types from 00-FFH.when an INT instruction
Is executed the type byte N is multiplied by 4 and the contents of IP and CS of the interrupt service routine will be taken from the hexadecimal multiplication as offset address and 0000 as segment address.for the execution of this instruction IF (interrupt flag) must be set.
• IRET(interrupt return):
When an interrupt service routine is to be called before transferring control to it,the IP,cs and flag register are stored on the stack memory to indicate the location from where the execution is to be continued after the ISR is executed.
At the end of each ISR when IRET is executed the value of IP,CS and flags are retrived from the stack to continue the execution of main program.
b) conditional branching instruction:
• JZ/JE (jump if zero flag is 1)
• JNZ/JNE(jump if ZF=0)
• JS (jump if SF=1)
• JNS (jump if SF=0)
• JO (jump if OF=1)
• JNO (jump if OF=0)
• JP (jump if PF =1)
• JNP (jump if PF =0)
• JB/JC (jump if CF=0)
• JNB/JNC (jump if CF=0)
• JBE (jump if ZF=1 or CF=1)
• JLE (jump if ZF=1 OR CF=0)
• JL (Jump if CF=0)
• JNL (jump if CF=1)
• JNBE (jump if CF=0 or ZF=0)
• JNLEW (jump if CF=1 or ZF=0)
Flag manipulation:
• CLC (clear carry)
• CMC (Complement carry)
• STC (set carry)
• CLD ( clear direction flag)
• STD (set direction flag)
• CLI (clear instruction flag)
• STI (set instruction flag)
Machine control instruction:
Memory segmentation:
Te memory in 8086 up based system is organized as segmented memory.in this scheme the complete physical memory may be divided into a number of logical segment.each segment is 64kb in size and is addressed by one of the segment register.
The sixteen bit content of the segment register actually point to the statrtiog location of a particular segment.to address a specific memory location within a segment we need an offset address.the off-set address is also 16-bit long so that the physical address formed 20-bit long by using segment atarting address and offset address.
Suppose,CS=2000H and offset=1000H
CS X 10 =20000
+OFFSET =1000
Physical addresss =21000H
The total 1 MB memory can be access by 1 HP 8086 and each segment is of 64 kb long. Hence the total number are available.
For accessing computer programs go to TECHNOLOGY


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Micrograph showing MDS

MADRID—Interim results of a phase 1 study suggest flotetuzumab, a CD123 and CD3 bispecific antibody, may be a feasible treatment option for relapsed or refractory acute myeloid leukemia (AML) or intermediate/high-risk myelodysplastic syndromes (MDS).

Researchers said flotetuzumab demonstrated acceptable tolerability in the dose-escalation portion of the study, with infusion-related reactions (IRRs) and cytokine release syndrome (CRS) being the most common adverse events (AEs).

In addition, flotetuzumab exhibited anti-leukemic activity in 8 of 14 response-evaluable patients, with 6 patients achieving a response.

Norbert Vey, MD, of Institut Paoli-Calmettes in Marseille, France, presented these results at the ESMO 2017 Congress (abstract 995O*). The study is sponsored by MacroGenics, Inc., the company developing flotetuzumab.

Flotetuzumab (MGD006) recognizes CD123 and CD3. The primary mechanism of flotetuzumab is thought to be its ability to redirect T cells to kill CD123-expressing cells. To achieve this, the molecule combines a portion of an antibody recognizing CD3 (an activating molecule expressed by T cells) with an arm that recognizes CD123 on the target cancer cells.

In this ongoing phase 1 study of flotetuzumab, researchers have enrolled 47 patients with a median age of 64 (range, 29-84). About 89% of these patients had AML (n=42), and the rest (n=5) had MDS.

Twenty-four percent had relapsed AML (n=10), 55% had refractory AML (n=23), and 21% had failed treatment with hypomethylating agents (n=9). One patient had intermediate-1-risk MDS, 2 had intermediate-2-risk, and 2 had high-risk MDS.

The study began with single patients receiving flotetuzumab at escalating doses—3 ng/kg/day, 10 ng/kg/day, 30 ng/kg/day, and 100 ng/kg/day.

Then, patients received a range of doses on 2 different schedules for cycle 1. One group received treatment 7 days a week. The other had a 4-days-on/3-days-off schedule.

All patients received a lead-in dose during the first week of cycle 1. They received 30 ng/kg/day for 3 days, then 100 ng/kg/day for 4 days.

For the rest of cycle 1, patients in the 4 days/3 days group received doses of 500 ng/kg, 700 ng/kg, 900 ng/kg, or 1000 ng/kg. Patients in the daily dosing group received doses of 300 ng/kg, 500 ng/kg, 700 ng/kg, 900 ng/kg, or 1000 ng/kg.

For cycle 2 and beyond, all patients were on the 4-days-on/3-days-off schedule.

The maximum tolerated dose and schedule was 500 ng/kg/day for 7 days.

Dose-limiting toxicities occurring at the 700 ng/kg/day dose included grade 2 IRRs/CRS in 2 patients and grade 3 myalgia in 1 patient. There was 1 drug-related central nervous system AE that led to treatment discontinuation.

IRRs/CRS occurred in 77% of patients, with 13% of patients having grade 3 events and 8.5% of patients discontinuing treatment due to IRRs/CRS.

The researchers said they found ways to decrease the incidence and severity of CRS. One is early intervention with tocilizumab. The other is a 2-step lead-in dose during week 1. So patients first receive 30 ng/kg, then 100 ng/kg, and then their target dose.

Other grade 3 AEs occurring in this trial include febrile neutropenia (11%), anemia (11%), and decreases in platelets (13%), white blood cells (11%), and lymphocytes (13%).

The researchers said they observed encouraging anti-leukemic activity in patients treated at 500 ng/kg/day or greater.

As of the data cut-off, 14 patients treated at this dose were evaluable for response. Eight (57%) patients had anti-leukemic activity, with 6 (43%) of these patients experiencing an objective response.

One patient achieved a complete response (CR), 2 had a CR with incomplete count recovery, and 1 had a molecular CR.

In most responders, anti-leukemic activity was observed after a single cycle of therapy.

MacroGenics is currently enrolling patients in dose-expansion cohorts. The company plans to present updated results from this trial at another scientific conference later this year.

*Slides from this presentation are available on the MacroGenics website at

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