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The HME Business June DemoCast

Stay in the loop about your HME supply chain with this our latest online learning service.

HME Business DemoCast

Our first HME Business DemoCast in May was sold out and was so well attended that we are bringing you a second installment! You can count on HME Business to keep you in the loop with new HME products and services. It’s like having all the best parts of a trade show expo streamed directly to your computer!

The HMEB DemoCast collects several new compelling products into a single online event that lets you watch several short presentations and video demos of the products and services your patients and referral partners need, and then follow up by asking experts representing some of those products and services in real-time during live Q&A sessions.

This HME Business DemoCast will help you:

  • Discover the latest HME products and services on the market.
  • Get detailed information and videos on each product.
  • Interact with representatives from those vendors via live Q&A.
  • Share these solutions with your patients and referral partners.

Date: Thursday, June 18, 2020
Time: 2:00 p.m. (Eastern) / 1:00 p.m. (Central) / 11:00 a.m. (Pacific)
Duration: 1 hour

Our Host:
David Kopf, Publisher and Executive Editor, HME Business
As Editor and Publisher, David Kopf is committed with ensuring that HME Business delivers news, trends and insights that help HME providers add value to post-acute care and run thriving, growing businesses.

DemoCast Access:
All registrants will have access to the live event and an on-demand recording of the presentation. If registrants want to watch the presentation again or have a scheduling conflict, they can register and access the on-demand version of this DemoCast, which will be available after the live event.

A special thanks to our sponsors for providing this free event.

Synzi’s HIPAA-compliant virtual care platform and telehealth apps enable healthcare organizations to conduct virtual visits and use secure messaging, text, and email for clinician-to-patient and clinician-to-clinician communications. Using Synzi leads to better adherence and reduced rehospitalizations as well as enhanced patient satisfaction and outcomes.

For 20 years Universal Software Solutions has focused on providing flexible solutions. Our Healthcare Data Management System (HDMS) provides customer service, inventory, delivery & shipping logistics, med doc management, EDI connectivity, and AR Management offered as either a hosted or on-premise solution.

Medline has unparalleled resources, breadth of products and expertise to help build and attract new customers. Our products and powerful marketing and merchandising tools help you stand out from the competition. When you partner with us, your success becomes our business.

Prochant is a leading HME billing and process outsourcing company. Our highly-skilled team helps providers become more profitable by outsourcing or enhancing front- and back-office processes. We rapidly implement changes and proactively monitor metrics for client success. Headquartered in Charlotte, North Carolina, we work with top providers and health systems.

McKesson Medical-Surgical is a medical distributor offering medical supplies, healthcare solutions, distribution services and clinical resources. Browse our vast selection of medical products and healthcare resources to help support the health of your business.

Your e-mail address is used to communicate with you about your registration, related products and services, and offers from select vendors. Refer to our Privacy Policy for additional information.


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Make The Most Of ACL: Marketing Tips

Make The Most Of ACL: Marketing Tips

Posted on Oct 02, 2017 by

It’s the beginning of October and every Austinite knows what that means—the first weekend of Austin City Limits. Whether you’re a festival goer or festival avoider, this weekend will impact us all. ACL brings people from around the country to the city of Austin, giving our businesses and the city itself unique exposure. This weekend, the city will be packed with music, events, locals, and travelers from around the world. With hundreds of festival-goers hitting the streets of Austin, this is the perfect weekend to take advantage of blockchain marketing and consulting opportunities for your business.

Even if you aren’t a music lover, ACL brings all sorts of people to Austin. Travelers will be wandering the city and could be the perfect consumer, partner, or even employee for your business. Be on the lookout for pop-up events to network and build exposure for your business. Connections can be made anywhere, even at late night shows. Make sure you’re on your A-game.

Take advantage of 450,000 people in one place. Pass out free merchandise, flyers, booklets, stickers, or anything else that shows off your brand outside the venue. This is a time to be creative and use guerilla marketing tactics to gain exposure for your business. Find an immediate need festival goers might have and satisfy it, while advertising your brand. Utilize busy times of the day, such as when the festival ends, to maximize your reach. Field marketing could be the perfect way to expose your brand to a new audience.

Social Media

Attending ACL can also be a way to increase your brand exposure this weekend. Take a picture displaying your brand at the festival and post it to your platforms. Take a picture displaying your brand at the festival and post it to your platforms. By locating, tagging, and hashtagging your post, you can show up organically on users feeds. ACL will be the top trending event on social media for the next two weeks and it is crucial for your brand to be a part of it. Get creative and find ways to take advantage of this event through all of your social platforms.

Nationally, ACL is the most popular festival and it is imperative that your brand is involved. Whether it is finding ways to connect, passing out merchandise, or actually attending the event, ACL holds a lot of promise in reaching your target audience. Take advantage of all that ACL has to offer and develop a marketing strategy that will emanate your brand. Get creative and gain the brand exposure you’ve been waiting for.

Anna Vehslage

Advertising Student, UT Austin; Marketing and Social Media Intern, Blogger for HMG Creative; Hook’em Horns, Coffee connoisseur, and burgers on Saturdays. Follow her on Instagram @annavehslage

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We Treat The Cause Of Your Pain

Millions of nerves travel throughout our bodies to control movement and function. Spinal joints, and extremity joints that are “out of alignment” do not move properly and cause pain and numbness by irritating (pinching) delicate nerves, muscles, tendons and ligaments. When irritated (pinched), these tissues alert your brain that something is wrong by creating pain, soreness,and stiffness.

Pain will wear us out making us tired and even depressed. We seek to locate and correct the source of your symptoms and address the underlying cause so the problem doesn’t keep recurring.

Getting you back to feeling yourself again quickly and effectively is our primary goal!

Happy Lady
360-326-3396 Book Appointment


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4 Ways to Successfully Build a Bootstrapped Business

5 min read

Opinions expressed by Entrepreneur contributors are their own.

Many aspiring entrepreneurs think the key to growing a successful is linked to the ability to secure investor funding. For some businesses this may be true, but many successful companies have been built from the ground up with no outside investment or support, aka bootstrapping. It takes great dedication, strong work ethic, sweat equity and an immense amount of drive to bootstrap a to success.

Today, the majority of entrepreneurs are bootstrapping their companies. One recent report found that of the 202 million working-age adults in the United States, 27 percent are either running a business they own and manage or starting such a business. Of these, 33.1 million are in the entrepreneurial phase (starting or running a business for less than three and a half years). Now consider that is used by only 0.5 percent of those 33.1 million entrepreneurs for startup capital.

Growing a business using a self-sustaining approach requires a strong vision for the company, supported by a focus on several key areas. These include developing a model, prioritizing and retention, building transparency into the company’s DNA, and strategically expanding the company’s footprint and offerings.

Related: The 7 Elements of a Strong Business Model

1. Acquiring and retaining customers

Instead of chasing after funding to drive growth, bootstrapped companies devote their time and attention to customer acquisition and retention. With no outside investment, it is critical for bootstrapped businesses to build a customer base quickly to generate positive cash flow.

Attracting new customers and boosting loyalty in existing customers can come from listening to what they need and paying attention to their feedback about the company’s product or service and using this input to develop offerings that deliver the most value.

GitHub, a web-based hosting service for software development projects, is a prime example of this. The company, which functions as a social network, portfolio space and co-working space, started as a weekend project funded entirely by its three founders. As the project began to take off, programmers began requesting additional features to project their data, and the founders knew it was time to make the project a full-time job. The team began releasing new products tailored to accommodate customer requests and the business skyrocketed to success, currently serving 50 million developers worldwide.

Related: Are You Sitting on a Customer Retention Goldmine?

2. Developing a sustainable business model

Finding a problem and then developing a solution are foundational to successfully growing a bootstrapped company. Developing a business model that solves core problems serves a gap in the market and provides real value to customers, allowing businesses to quickly start selling services or products to establish and sustain cash flow.

Building a bootstrapped business allows for flexibility that a company backed by outside investors may not have, namely slowly and quietly growing to develop paying customers that offset the business costs rather than facing the expectation to prove high growth from the get-go to boost investor trust.

Different markets have different challenges, of course, but common among bootstrapped businesses is the desire to fill a market need and solve for its pain points.

3. Practicing transparency

Customers are the only metric that counts for bootstrapped companies. In order to attract and retain customers, a company must make transparency part of its DNA. In a digital world where consumers have easy access to company information and reviews, customers expect and demand transparency from businesses. Business buyers want openness and honesty along their entire buying journey. A 2019 report by Marketo and on Creating Epic Customer Experiences found that 78 percent of business buyer survey respondents cited brand transparency as a top purchasing driver.

Business transparency is a game changer that can fuel business growth. Companies that practice transparency build strong, positive relationships that increase long-term customer loyalty, which in turn generates ROI in the form of profits and long-term .

Related: How Transparency Became a Top Priority for Businesses, and Why You Should Care

4. Growing through acquisition

Bootstrapped companies can also set themselves up to grow through impactful and strategic acquisitions. One of these growth strategies is horizontal acquisition, which involves buying a competing company to increase market share and/or scalability and accelerate company growth. When a company acquires a competing company, it gives them the ability to tap into existing elements such as key executives, proprietary and customer databases.

Building for the long term

The willingness and patience to grow at a smaller scale initially allows you to have the freedom to build up a company culture without outside pressure, while simultaneously retaining 100 percent ownership of your company and future vision. With the bootstrapping approach, founders call the shots on operating and growing the company.

While growing a bootstrapped company involves a lot of moving parts, a focus on prioritizing customer acquisition and retention, developing a sustainable business model, building transparency into the company’s DNA  and strategically expanding the company’s footprint and offerings can drive company growth and long-term sustainability.


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Messy Play For Matilda Mae

Messy Play For Matilda Mae

As we are currently away on a little break I have not had time to write this week’s messy play post, however I wanted to put together a little one to share the fun we had. Ths week’s theme set by Edspire was Pink & Purple.

I put together our water table and froze some pink & purple ice cubes with some little peaks inside. I added these to the water and gave them children some cups, spoons and a sieve for fishing and off they went.

They are quite familiar with water play now, in fact it’s all I can do to stop Baby J jumping in before it’s all set up! Although it did also see him standing on his own for a few seconds – a proud mummy moment!

I added some pink & purple food colouring to some shaving foam and gave them paintbrushes, just to add another element to the play. Here are a few photos from our fun.

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How to Grow Germander

The common name germander refers to a group of perennial shrubs within the genus Teucrium, which are native to the Mediterranean basin. They grow best within U.S. Department of Agriculture plant hardiness zones 5 to 9, where they will reach a mature height of 1 to 3 feet with a 12-inch spread. Germander withstands drought and poor, sandy soil with minimal damage, and will thrive despite neglect. However, the plants perform best if provided with regular irrigation, yearly feeding and occasional pruning to invigorate their blooming and foliage production.

Plant germander in a garden bed with full sun exposure and sandy, fast-draining soil. Choose a spot where the soil pH is between 7.0 and 7.9, which is neutral to mildly alkaline. Avoid deep shade and areas with organically rich, acidic soil.

Space the plants 10 to 12 inches apart to create a dense, bushy appearance while still maintaining adequate air flow between the plants. Prune back any surrounding vegetation to prevent crowding.

Water germander weekly to a depth of 3 inches during its first summer in the garden. Water with the hose nozzle at the base of the plant instead of spraying from above, as excess moisture on the foliage creates ideal conditions for mildew.

Water to a depth of 2 inches every seven to 10 days once the plants are established. Irrigate the plants only in summer. Increase water by half during periods of prolonged drought or heat.

Avoid watering in the winter unless no rain falls for longer than three weeks. Provide just enough irrigation to keep the plants from wilting. Withhold all water during rainy weather since excess moisture in the soil will cause the roots to drown.

Feed germander yearly in spring using general purpose fertilizer with an N-P-K (nitrogen-phosphorus-potassium) ratio of 12-12-12 or 10-10-10. Apply the fertilizer at quarter-strength and water thoroughly afterward.

Prune off the spent blossoms once the germander finishes blooming. Snip off the spent flowers just below the head and discard them. Use freshly cleaned, sharp pruning shears to prevent infections.

Cut back the entire germander plant in early spring to promote a fuller, bushier appearance in summer. Trim off all the stems to 2 inches above ground level using pruning shears.

Things Needed

  • Soil pH test kit
  • 12-12-12 ratio fertilizer
  • Pruning shears

  • Amend the soil at the planting site with limestone if it is highly acidic.

About the Author

Samantha McMullen began writing professionally in 2001. Her nearly 20 years of experience in horticulture informs her work, which has appeared in publications such as Mother Earth News.


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How Tree Roots Affect Soil

The trees in our yard improve our quality of life. They beautify the landscape, give us shade from the sun, produce oxygen, and invite birds to our property. Some trees produce edible fruit and others lace the air with the intoxicating aroma of flowers. The roots of a tree typically extend underground beyond the canopy of the tree. Naturally, these roots can affect the surrounding soil in both positive and negative ways.

Improve Structure

Improving the soil’s structure increases fertility and helps prevent soil erosion. A tree’s penetrating roots improve the soil structure by improving aeration and drainage. Probing root growth breaks up the soil, which creates spaces for storing air and water. Tree roots improve drainage because each root acts as an underground water channel to help water penetrate the soil.

Add Nutrients

Some trees' roots add nutrients to the soil, which naturally fertilizes surrounding plants. The roots from leguminous trees add nitrogen to the soil by a process known as nitrogen fixation. Leguminous trees produce long flat pods and include the genus Acacia, Cassia and Prosopis. Eucalyptus and Jack Pine (Pinus banksiana) exude substances from their roots that increase the availability of phosphorus.

Soil Erosion

A tree’s deep, strong root system protects against soil erosion due to heavy rain and flooding. The roots of healthy, mature trees do the best job of preventing soil erosion, whether the tree produces many smaller roots or a few larger tap roots. After the tree dies, or is cut down, the roots still hold the soil in place. However, over the course of about three years, the roots of a dead tree become increasingly ineffective at preventing soil erosion.

Juglone Toxicity

Black walnut (Juglans nigra) and Butternut (uglans cinerea L.) trees releases the substance juglone that makes the surrounding soil toxic for many plants. The toxic ring in the soil around these trees grows as the root system gets larger. Mature trees can have a toxic ring between 50 and 80 feet wide. Plants, including tomatoes, apple trees and azalea bushes, will perish within one to two months of planting them in this zone. Luckily many plants, including, melons, Japanese maples and zinnia aren’t affected.

Photo Credits

  • Thinkstock/Comstock/Getty Images

About the Author

Victoria Weinblatt began writing articles in 2007, contributing to The Huffington Post and other websites. She is a certified yoga instructor, group fitness instructor and massage therapist. Weinblatt received her B.S. in natural resources from Michigan State University and an M.Ed. from Shenandoah University.


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Don’t Shop! Adopt!

It’s not fair to say, nor is it true, that Mexicans don’t love their dogs. Most dog owners in Puerto Vallarta treat their dogs just the same as their northern counterparts. Like anything else, it’s the few bad apples that seem to put a rotten tinge on the entire barrel and that is simply not right. Veterinarians abound in Puerto Vallarta and they aren’t all here just for expats. As a matter of fact, when you pass through any of the small villages you will see their signs that prove it’s a competitive business. It’s not unusual at all to hear our Mexican friends discuss their preference for one vet over another, just like we do.

The problem of stray dogs in Puerto Vallarta has gotten better over the years; this in thanks to expat groups working with locals to set up spay and neuter clinics, promoting adoption of puppies and kittens and aging pets. There are reasons an older pet is surrendered; sometimes the owner has died or been incapacitated, and new homing is needed. These little critters need love and reassurance, but it’s not a tough job. It’s a great idea for someone living alone and seeking companionship.

There are, indeed, neglected animals in Puerto Vallarta. Not all Mexicans, just like anywhere else, agree that pets should be kept in homes, fed properly and groomed. An owner might stake a dog in front of their house, chained and starving, to ward off intruders. (How this works when a dog can’t run is anybody’s guess.) Cats that are kept simply to catch rats often have a very short life and painful death, when eating a poisoned rodent. These animals are sometimes rescued by local groups, intent on adopting them to local homes or new lives north of the border.

It’s illegal to sell puppies in Puerto Vallarta. Last month we encountered a man with two tiny pups on the streets in Zona Romantica. He began to answer our questions unsuspectingly, thinking we were interested in a purchase. He knew he was breaking the law; we took his photo with our phone while he was fleeing. If you encounter one of these rogues, locate a police officer and arrange a rendezvous. There are police officers  everywhere so it won’t be a difficult task and the police are glad to apprehend these petty criminals, as they cause problems that distract from graver duties.

If you’re interested in owning a dog in Puerto Vallarta or bringing one back home, adopt; don’t shop.

Que es cómo es.

Thanks to our guest blogger Adam Garcia (opinions expressed are his own)

Here are a few of our guiding principals at Boardwalk Realty:

“First of all, we really want to get to know you,”   When we know you, we can tailor home tours to your tastes.”

Secondly, there’s the legal side of owning in Mexico. “Besides our own experience, we can save you a lot of time and money by offering you complimentary consultations with our partner attorneys.  The nuances of how you buy here can save you a lot of money when you sell. It’s important to know what you’re doing on the purchase so that when you sell you can best use any tax advantages. This service is free to our clients and can be invaluable.”

Both partners agree that the most important element of Boardwalk Realty is our ongoing service and commitment to our clients after the sale.  We are both passionate about protecting the investment and security of our clients.  “Our clients become our friends, we see them socially, and we treat them as we would like to be treated ourselves”, adds Mike.

Boardwalk Realty Puerto Vallarta represents buyers and sellers of real estate in the entire Bay of Banderas area, and will soon add a rental and property management division.


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The paper should be 3-4 pages long, and it must include direct quotes from the sources, citations, and works cited page (or bibliography). The paper must be structured according to either the MLA or APA method. The body of the paper should begin with an introduction that clearly states the thesis (main idea) and purpose, build an argument in succeeding paragraphs, and end with a conclusion. Avoid plagiarism of any kind, and submit only your own work. Please double-space your paper and utilize a font of 12. If you submit the paper late, the grade will be penalized.

2. Write a paper about the presidential election of 2020. What do you think are the major issues in this year’s election? What role will political parties, interest groups, and the media play in the election campaign? What were the results of the primary elections in 2020, and who emerged as the nominees of the Republican and Democratic parties? Discuss the results (if known by November 24) of this year’s election. How accurate were forecasts based on polling this year?

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John Lennon would have been 80 years old last Friday.

Had he not been shot dead 40 years ago.

Gimme some truth

I’m sick and tired of hearing things
From uptight, short-sighted, narrow-minded hypocritics

All I want is the truth
Just give me some truth

I’ve had enough of reading things
By neurotic, psychotic, pig-headed politicians

All I want is the truth
Just give me some truth

Which year did he write this song again???

Sounds to me like as if there’d be a good chance he’d be shot a second time one of these days had he survived the first attempt to kill him and had he continued to sing that kind of song.

This past week, Pádraig was back on his feet and back on the Lokomat.

I keep imagining. – Could Pádraig have been spared more than a year of deeply troubled nights and lack of sleep and what must have been at times excruciating pain?

A ‘good night’ before the intervention he went for recently meant he had slept continuously for a few hours, maybe five or six, and that was a rare occurrence. Most nights were not ‘good nights’. During those nights he slept maybe one or two hours, woke up for an hour or two, moved around in the bed in pain and went back to sleep for another one or two hours, because of sheer exhaustion.

We had to protect the sides of his bed with thick foam covers and close the gaps between the mattress and the bed side protectors with specially made foam covers to prevent injuries.

It must have been close to unbearable for Pádraig to be unable to get a good night’s sleep. It was extremely difficult for anybody staying with him for a night to see him struggling so hard, being unable to rest, pulling up his legs, especially his right leg, almost up to his chin, twisting his legs around each other, over time being unable to stretch out his right leg anymore because these movements had caused his right hip to sublux, pushing the head of the right femur (partially) out of the socket.

We asked everybody we could think of. Described what was happening.

Eventually, we decided that we had to go on a long journey to get Pádraig the help he so desperately needed.

Following his discharge from the rehab hospital in Burgau, we have been staying with Pádraig now for more than two weeks during the nights. He goes to bed in the evening. We help him to turn around twice or three times during the night. He wakes up in the morning. After a really good night of at least eight hours, and often 10 hours or more of sleep.

The difference between ‘before and after’ could not be bigger.

I keep imagining. What would have happened to Pádraig had we not taken him to see the specialists in Burgau and Munich, had we allowed his condition to gradually deteriorate? Had he not eventually received the necessary help by people who cared, and for whom Pádraig has the same right to physical integrity, to his health, as you and I? Who treated him with ‘dignity and respect’? Who took a ‘patient centred’ approach? Who did not discriminate because of an existing condition?

Is not knowing as bad as not acting despite the knowledge?

I’m sick and tired of hearing things
From uptight, short-sighted, narrow-minded hypocritics

John Lennon sang nearly 50 years ago. Maybe Heraclitus of Ephesus, the Ancient Greek, pre-Socratic Ionian philosopher, got it wrong when he found: “Panta rhei” – everything flows and everything changes?

It’s 40 years ago this month that I met my soul mate in the Calle Rúa Mayor in Salamanca. Yesterday, 35 years ago, we got married. One day, we’ll go back there. Some people will always have Paris. We’ll always have Salamanca.


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Washington's Most Popular Halloween Candy!

October 11, 2018

Michael Gray | Dreamstime.com

According to Candystore.com, the most popular Halloween candy in Washington state is salt water taffy!

They ranked the top three candies for each state and based it of 10 years worth of sales data.

Apparently the people in Washington buy about 220,000 pounds of salt water taffy to hand out during Halloween! Salt water taffy is good and all but I would have never thought!

Tootsie Pops came in at second place, with about 195,000 pounds bought and Skittles were third.

See the graph below!


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Apple May Still Need Samsung to Supply Retina Display for Next iPad Mini

You've probably heard the adage, "Keep your friends close and your enemies closer," and certainly Apple's done that with Samsung, though only because the Cupertino company may have no other choice. It's no secret there's plenty of bad blood between Apple and Samsung, the two mobile giants vying for dominance in the smartphone and tablet sectors, and while the former would like to severe ties with the latter, breaking up completely is proving hard to do.

Initial reports regarding Apple's second generation iPad mini tablet suggested Sharp and LG would provide the upgraded Retina-class panels rather than continue to rely on Samsung. However, after speaking with "people familiar with the matter," The Wall Street Journal reports that Apple got cold feet and decided it was best to add Samsung to the mix to prevent any supply issues.

iPad Mini

This all assumes the next iPad mini device will boast a Retina-class display in the first place. Apple has neither confirmed or denied this, nor has the company even confirmed that there will be another iPad mini. There will be, of course, and barring a major surprise (and letdown), you can bank on an upgraded display finding its way onto the spec sheet.

Even though Apple and Samsung have their issues behind the scenes, none of their legal bickering is likely to affect consumers as it pertains to the iPad mini, not unless an unrelated patent infringement suit pops up. Otherwise, these two rivals have been working together for several years, with Samsung supplying vital parts for a range of Apple devices.


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Apsley 162 at Lot 217 Hickson St, Horsham, VIC 3400

43740 – Apsley 162, Horsham VIC
Residence 116.18 m²
Garage36.05 m²
Alfresco8.06 m²
Porch1.71 m²
Total162.00 m²
House Width11.10 m
House Length16.13 m
Width x Length
Master Bedroom 3.40m x 3.30m
Bedroom 2 2.90m x 2.90m
Bedroom 3 2.90m x 2.90m
Family 3.00m x 4.22m
Dining 2.44m x 4.22m
Garage 5.50m x 6.00m

As a compact design, the Apsley incorporates all the features you would want in a first home.

A compact design that incorporates all the features you would want in a first home. The Apsley 162 is the ideal home for a young family. Key features include a master bedroom with ensuite and walk-in-robe, two bedrooms with a bathroom and separate toilet, open-plan living with direct access to the alfresco, study nook and double car garage.

$ 326,207

  • Jamieson 248

    Home Width:

    Lot 2 Plant Ave, Horsham, VIC 3400

    $ 587,179

    • 4
    • 2.0
    • 2

    Leneva 185

    Home Width:

    47 Hickson St, Horsham, VIC 3400

    $ 359,115

    • 4
    • 2.0
    • 2

    Birchgrove 164

    Home Width:

    Lot 2 2 Kalimna Ave, Horsham, VIC 3400

    $ 403,554

    • 3
    • 2.0
    • 2
Affordable House and land packages

Hotondo Homes offer a large range of house and land packages in Melbourne, Sydney and nationwide, that can be found in new developments as well as established communities.

Our home and land packages are great value for money and provide maximum convenience. They have been designed to save time and money, as the home design is already suited to the perfect block of land.

A house and land package features the affordability of your new home and is ideal for investors as the hard work of matching a home and a block of land is already done.

Our selection of packages reflect our range of modern new home designs, featuring large open plan living areas, master bedroom retreats, outdoor alfrescos and versatile rooms that adapt with the changing needs of a growing family.

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Tracks Info: un film de 2 06:27 / so süss 04:47 love in my eyes 05:23 / stomp that beat 04:13 “pretty in plastique” links closely to their “seid bereit!” 12inch on EC some couple of years before - but they have polished their 80ies pop and new wave interpretation. It´s more straight forward melody orientated synths with not losing their classic trackprogramming, analog basslines and strings. “pretty in plastique” shows the other part of the story where MAS 2008 are really from! – early 80ies avantgarde-pop. The weird “love in my eyes”, the DAF like “so süss” (engl.: so sweet) and the french filmic atittuded “un film de 2” – brings back the flair of a time.

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Artist MAS 2008 3 Release date2008-02-21 AvailabilityIn stock Delivery1-3 days Item no78631 Product groupVinyl Media12" Catalogue numberELCO 012 Record labelElectronic Corp. 9 GenreTechno / Trance 152 ConditionNew, unplayed


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How To Grill a Porterhouse Steak

The Porterhouse is a man’s steak if there ever was one. It’s basically two steaks in one the NY Strip on one side of the bone and the filet on the other. The bone gives both cuts tremendous flavor and when cooked just right, you won’t find a better steak. That’s why the Porter House demands the most money on restaurant menus. I like them about 1 ½” thick which weighs in around a whopping 24oz. For you light weights you may want to stick to a petite filet or small Ribeye but if you’re serious about wanting a steak than you should go with a porter house. I shot a video that walks you through the entire process of cooking this monster…. For me, the porterhouse is all about beef flavor. It doesn’t require any marinades or fancy seasonings or rubs. I just want to enhance the beef flavor in the meat – and it only takes 3 simple ingredients… salt, black pepper and a touch of garlic. The key to cooking this steak is having a hot grill. I’m talking temps in the 500 degree + range. I want to quickly sear the outside to lock-in all the flavors and juices of the steak. And I don’t believe in taking steaks past medium rare… that’s sacrilege in my book. If you want something well-done, you might as well go with a meat loaf. It takes about 20-25 minutes for the coals to get ready. And that’s the perfect amount of time for the steaks to set out and come up to room temperature. The meat needs to set out because the steak will cook more evenly if it’s all the same temperature throughout. While the coals are getting hot, I brushed the outside of my steaks with a little olive oil and then seasoned them lightly with black pepper, garlic and just a touch of salt. I don’t go heavy on the salt at the beginning because it tends to draw-out too much moisture from the meat… so I save most of the salt until the end. Steaks this size need about 5 minutes on each side. But to get the diamond pattern, you give them a 90 degree turn half-way through the cook. This is a very fast cook, so you want to keep a timer on it because you don’t want it to get away from you since your cooking at such a high temperature. After the first 2.5 minutes you turn 90 degrees – keeping the steak cooking on the same side. Then after another 2.5 you flip your steak to the other side. Let it go another 2.5 minutes and turn 90 degrees again to create the cross-hatch pattern on that side. And after another 2.5 minutes you’re done. If you just have to check the internal temp it should be right at 125 – 130 degrees. The most critical part is the rest. Since you cooked this steak so hot and fast, it needs to sit there and calm-down. It allows the juices that were trying to escape to settle-down and the rest will make the meat juicier. You will also gain another 5 degrees during the rest period. Don’t forget to sprinkle on just another tough of salt at this point. It will really make the beef flavor pop. Malcom Reed Connect on Facebook Follow me on Twitter Subscribe to my YouTube Channel Find me on Google+ Follow me on Instagram Buy Killer Hogs Products Here

Comments 4

  1. I live in North Carolina, and one steak dilemma that I’ve faced over the last few years is whether to use a grilling or pan-searing method. I’ve experimented, using a variety of meats, heats, and durations–I’ve even tried an old fashion cast iron skillet–but I still haven’t reached a conclusion. On one side a pan-sear provides an even, delicious crust, while charcoal provides the signature grill marks and smoky flavor. Either way a well cooked steak is a beautiful thing, and I agree that no good piece of meat should be seasoned beyond the basics, but have you ever compared the two and taken a side?

    1. Post

      Yep. I use a cast iron skillet to cook steaks with the pan-searing method. It works, makes a great crust just like you said… but to me, it’s just missing the flavor a grilled steak has. I use the pan method when it’s really cold or raining, and it makes a great steak. But my personal preference is grilling.

  2. Pingback: Comment on How to BBQ Right’s “How To Grill a Porterhouse Steak” | Frey Facts

  3. Hi . We are having a company bbq on friday . And sence I’m always the guy bbqing and bringin it to work for my lunch at least 3 times a week .I was nominated to ne the cook. The meat is porterhouse steaks on a charcoal grill. Mabe u can give me some tips. My methood is 2 to 2 1/2 min then turn the meat at a 90 dagree angle for another 2 min to get that reastaraunt look to it then flip and do the same on other side. Im looking for a med rear . Dose that sound right thanks. Dino.

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Tonight is Kanelbullens Dag Eve.

OK. It’s Cinnamon Bun Day’s Eve. In Sweden tomorrow, all sorts of people will be celebrating the little round wonders that are cinnamon buns.

I love cinnamon anyway, so last year I had a little cinnamon Danish all by myself to celebrate; this year in my pursuit of all things hyggelig, I am determined to force cinnamon buns on all my family.

If I were in London, I’d be well away for authentic Scandi choices, as this article on 12 Delicious Nordic Cafes in London from Buzzfeed shows. I could get lost just looking at all the instagram-worthy pictures on here. But (despite never having been there) I have one cafe above all others that I am desperate to visit;

Pictures lifted from the Buzzfeed article credited below; until November 12th when I shall replace them with my own!

Scandinavian Kitchen, at 61 Great Titchfield Street, is on my Must Do list for my next London trip on the 12th November this year. I have no idea of the etiquette of visiting a hero’s shrine. Do I walk and and go, “Hello, I’m Angel Kneale from How to Hygge the British Way and I’m obsessed with your Fika and Hygge cookbook. You’re part of the reason I’m living hyggely this year. Can I have a salmon Smørrebrød, please?”

Or should I act cool and Danish and just order and sit and take surreptitious photos of the beetroot salad and the cool coffee that I had to have, and the decor? I know the second is classic London, where nothing impresses nobody any more, but I am so not a Londoner. I was born with a thick stripe of puppy dog enthusiasm running down my centre. Break me open and , like Blackpool rock, it reads “Really Happy All the Time”.

I’d want to be saying hello to the staff, to be telling them I’ve got the book and it’s brilliant (and it is) and that I’ve saved up specially to come and that this is a big treat for me because lunch alone is a totally out of the ordinary affair, and lunch alone in a London Cafe a once (or twice) a year thing and that their cafe, out of all the cafes in London this year, is the place that I HAD to go to because this year I AM DANGLISH and desperate to mix with other Nordicophiles or Scandiphiles and yes, please, can I visit the deli and I’ll have this fish thing and this salted liquorice and this liquorice chocolate and a BIG bag of daims…..

But that’s for November, and I’m sure by the time November comes I will have calmed down a little. Today my issue is that tomorrow is Kanelbuller’s Dag and I want to make my own buns this year.

According to the internet sources I found, Cinnamon Bun Day was established by the Home Baking Council in 1999, in honour of their 40th anniversary. They’re now run by Dansukker, but the festival goes on. According to Wikipedia, the Swedish bun contains cardamon as well as cinnamon, giving it a distinctive taste, while The says that they are far less sticky than the American equivalent. “Nowadays cinnamon rolls can be found around the world, but in Sweden they’ve got that extra something – a touch of Scandinavian simplicity,” the article reads,  and interviewing the project manager at the Home Baking Council  they quote her as saying, ” ‘We’re experts at fika,’ Birgit Nilsson Bergström said with a laugh. ‘Our Swedish cinnamon rolls are simpler, more every-day, and yet tastier. They have less fat, less sugar… They’re more plain, but still festive for us, and very Swedish.’ ”

I’ve got my cinnamon, I’ve got my cardamon, I’ve got the recipe carefully copied from Scandinavian Kitchen’s website, How to Make Cinnamon Buns, I have set the time aside tonight for the rising, kneading and anything else it needs and i will probably bake tonight so that, as we sit down with our coffee after dinner, we can start the celebration of my hyggely year early.

Articles and webpages used in this post;

The; Cinnamon Bun day; What’s it all about?

Buzzfeed; 12 Delicious Nordic Cafes in London

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Human Resources Blog - Spark Hire

4 Ways to Attract Candidate Referrals

4 Ways to Attract Candidate ReferralsTalent acquisition is more than just candidate sourcing and applicants.  If you do not have a referral system in place at your business, now is the time to look into creating and implementing your own system. Even the largest and best known companies struggle with getting good candidate referrals at times and when creating your referral system, there are several things you should consider.

1. Get the word out

The first step to attracting candidate referrals is to make it known that you have an opening and that you are accepting referrals.  Let your current employees know that you are hiring.  Some of the best referrals will come from your existing employees.  It is well known that people tend to know like-minded people.  Wouldn’t it be great to receive candidate recommendations from your top performers?  In order for this to happen, you must take the first step by letting them know you are accepting referrals.

2. Offer rewards

One thing that many companies do is to offer rewards to their employees when they refer candidates.  It never hurts to dangle a small carrot when it comes to the referral game.  I have seen companies offer small rewards in the form of gift cards as well as pricier rewards such as large electronics.  Get creative with your referral rewards.  There is no set reward system or method for implementing this.  Perhaps conduct an office poll to find out what your employees would get excited about and take it from there.

3. Simplify the process

As with anything, if something is too difficult, many people will simply give up.  It is important that you make sure that your referral submittal process is quick and painless.  Is it easy for your employees to submit a referral to you, or do you require them to fill out tedious questionnaires about their referral?  Keep your process quick and easy and you will likely receive more referrals.

4. Check references

Did you know that one of the best ways to get referrals is by checking references?  Each time you speak with a candidate’s reference, do your best to develop a relationship with that reference.  Ask them questions about their company, what they do, and share some information about your company.  Find a common ground with the reference and let them know of any additional positions you will be hiring for in the future.  They just might know of someone who would be a great fit for your company, but they are unable to hire themselves.  On the other hand, the reference could be interested in working for your company!

What have you done in the past to attract candidate referrals?  Please share your tips in the comments below.

Image: Jakub Jirsak/

Julia Weeks

Julia is a skilled Recruiter with over 8 years of experience in sourcing, interviewing, and hiring within many industries globally. She works closely with hiring managers and job seekers to understand needs and desires, while offering guidance and ensuring the right fit. When not recruiting or writing, Julia enjoys spending time outside cycling, taking her dog for walks, or honing her sailing skills.

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Web2application Convert you website to android and IOS apps

About Web2application

Web2Application.com convert responsive websites into applications and enable the use of advanced features such as push notifications, use of device options like gps, marketing tools and etc

The plugin support WooCommerce stores and all WordPress themes.

When you convert your website to android and iOS apps with our system you will enjoy:

  • Unlimited push messaging
  • Free upload to Google Play (for premium members)
  • Web push to chrome and firefox
  • Deep linking
  • Smart download link and QRcode
  • Add tab menu to your app
  • And many many more…
  • Whatsapp support (Premium Members Only)

For more information about how to convert your mobile website to android and ios apps, Please visit our website for more information:

Web2application WordPress Plugin

Convert your wordpress site into native mobile android & IOS apps, Enjoy sending push notifications and more advanced features
Start now for Free (IOS not included in the free plan)

Snimke zaslona

  • "Web2application" send push page
  • Send push notifications and web push from your wordpress admin
  • Add tab menu to your android aidn iOS apps from your wordpress admin
  • Get QRcode that will help your users to download your android and iOS apps
  • Special offers for your Android and iOS users only
  • Premium setting screen - part 1
  • Premium setting screen - part 2
  • Web push notification settings
  • Plugin settings

  1. In your WordPress Dashboard go to “Plugins” -> “Add Plugin”.
  2. Search for “Web2application”.
  3. Install the plugin by pressing the “Install” button.
  4. Activate the plugin by pressing the “Activate” button.
  5. Go to “Web2application” Settings section on the wordpress admin panel and enter your API key (there is instruction in the page).
    You nne to get your API key from our system – https://Web2application.com
  6. Go to “Web2application” Send Push section and send you notification to all your users

Minimum Requirements

  • WordPress version 4.0 or greater.
  • PHP version 5.2.4 or greater.
  • MySQL version 5.0 or greater.

Recommended Requirements

  • The latest WordPress version.
  • PHP version 5.6 or greater.
  • MySQL version 5.5 or greater.

What does the plugin do?

The plugin integrate web2application push notifications, web push settings, Setting to your android and IOS into your wordpress site and allow you to control your app throw you wordpress admin

Where can i get more info about Web2application ?

Please visit our website : http://web2application.com

My plug dont work and its say that my API is wrong

Please make sure you copy the exact url from the setting to our system and copy the API to the plug without any sapces.
if you still have probelms, please contact our support and we will be happy to help

Web Push Notifications dont work

In order to make the web push notification to work you need to make sure the web push setting are correct in our system. if you are a premium user please contact the premium support and they will setit up for you (please note, the web push feature is a premium feature)

What is the elementor support ?

some times there is some elements at the site that you dont want to show in the apps. For example, links to download the app from the stores.
With our Elementor widget you will be able to side those elements in your android and iOS apps only.

13. lipnja 2020.
i will never use that company services , i have paid them 99$ for nothing at all , they added their website's name on my app link on google store, then i found that they added also their own website's name on the application as copyright , FINALLY , the app is not working at all btw: after a month of your subscription that means you will lose the premium option and your app will get crashed for sure as i'm facing now and because of course you will have to go the support, then they will ask you to pay them more and more .
04. travnja 2020.
A lot of notice warnings, main page of plugin does not display anything. I can't use it 🙁 Need an upgrade to be used with WP 5.3.2 obviously
14. listopada 2019.
The best part they have a free version of the plugin. You can even check the changes in the actual app on their dashboard. The other plugin is too pricy. Web2application came up at a reasonable price. Also once I have purchased the premium version, I got 24/7 support from the developer. They will even help you with the app store registration. Loved it.
Pročitajte sve 4 recenzije

Suradnici i Programeri

“Web2application Convert you website to android and IOS apps” is open source software. The following people have contributed to this plugin.


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WP LinkedIn Auto Publish

WP LinkedIn Auto Publish lets you publish posts, custom posts and pages automatically from WordPress to your personal LinkedIn profile and/or company pages that you are an administrator of.

The plugin is simple, lightweight and free. It does have a couple of options which includes choosing who you want to share your LinkedIn posts with and whether you want to enable simple text-based sharing or more advanced sharing where you can tell LinkedIn to use your posts feature image. You can also setup a default share message format using time saving dynamic shortcodes for all your posts which you can over-ride on the post meta box settings. You can also filter items to be published based on categories selected on the plugin settings page. You can choose whether you want to share posts, custom posts and pages. You can select the default profile and/or companies you want to share with as well.

Every post will automatically be published to LinkedIn, however on each post there is a checkbox which enables you to not share a particular post. On a post page and on the all posts page you will also see a record of instances a post has been shared to LinkedIn.

Announcing AutoSocial

WP LinkedIn Auto Publish has now been put into maintenance mode which means we are only going to maintain the functionality and provide limited support. However we are now focusing our efforts on our new plugin AutoSocial which provides the same functionality as WP LinkedIn Auto Publish but adds Facebook, Google My Business and Twitter and many more cool features! Learn more

Snimke zaslona

  • Once you have installed the plugin, navigate to Settings > WP LinkedIn Auto Publish and with one click connect your account to your WordPress site!
  • Select the profile and/or companies you want to use with the plugin.
  • In the Sharing Options tab you can choose some additional sharing options.
  • On the Additional Options tab you can choose whether to hide the new post column and whether you want to share posts by default.
  • On every post page there will now be a new LinkedIn settings box where you can over-ride the default share message or choose to not to share the particular post with LinkedIn, or what profiles/companies you want to share with. If the post has been shared on LinkedIn it will also display a share history of the post.
  • On the all posts page there will be a new Shared on LinkedIn column which tells you which posts have been shared on LinkedIn or not and you can share instantly straight from that screen.
  • The plugin contains an FAQ on the settings page.

There are a couple of methods for installing and setting up this plugin.

Upload Manually

  1. Download and unzip the plugin
  2. Upload the ‘wp-linkedin-autopublish’ folder into the ‘/wp-content/plugins/’ directory
  3. Go to the Plugins admin page and activate the plugin

Install via the Admin Area

  1. In the admin area go to Plugins > Add New and search for “WP LinkedIn Auto Publish”
  2. Click install and then click activate

Frequently asked questions can be found under the help tab on the plugin settings page.

13. listopada 2020.
WP LinkedIn Auto Publish has now been put into maintenance mode which means we are only going to maintain the core functionality and provide limited support. However we are now focusing our efforts on our new plugin AutoSocial which provides the same functionality as WP LinkedIn Auto Publish but adds Facebook, Google My Business and Twitter and many more cool features! By moving everything to one premium plugin it means I can better consolidate my development time and release new features and provide better support. is what I see at first. That does not sound good at all. "maintenance mode" doesnt sound like I want it. Even worse the dev says he will be focusing on a paid plugin that provides EXACTLY THE SAME FUNCTIONALITY. That seems like a jerk move as we have seen in the fails of wp bakery, yoastSEO and so many other weird subscription models that do NOT PAY off but rather make people turn away. Or look at smush... same problem. Sure money is cool but leaving people hanging isn't. Dev could have gone patreon page or sth but chose to do the worst: he will store personal data on you for his licensing model. sure he has enough sec ops working for him...but that requires more money...
30. lipnja 2020.
Makes posting updates so much easier -- can do it from one page now instead of logging into different interfaces, copying, pasting, and editing... Thanks!
13. lipnja 2020.
This plugin is extremely easy to install/set up and makes it easy to publish posts to profiles and/or company pages. I wanted to use it to publish a custom post type to LinkedIn as well and Northern Beaches Websites offered to update the plugin for me so that this would be possible. Highly recommend. Thank you!
Pročitajte svih 48 recenzija

Suradnici i Programeri

“WP LinkedIn Auto Publish” is open source software. The following people have contributed to this plugin.

Prevedite “WP LinkedIn Auto Publish” na svoj jezik.

Zainteresirani ste za razvoj?

Pregledajte kôd, pogledajte SVN spremišteili se pretplatite na dnevnik razvoja od RSS.

Dnevnik promjena

  • Updates to custom post types

  • Support for more custom post types

  • Fixed line break issue

  • Restoration of don’t share by default feature

  • Updated to the latest version of the LinkedIn API – important after updating please re-authenticate the plugin

  • Update to advanced mode so if you don’t share an image the grey box won’t appear
  • Tested with WordPress 5.1.1

  • Further bug fix

  • Fixes test authentication bug
  • Tested with WordPress 5

  • Only shows re-authentication warning to admins

  • Announcing AutoSocial our new premium version of WP LinkedIn Auto Publish

  • Compatibility improvements with other NBW plugins

  • Updates to messaging in plugin FAQ and testing with WordPress 4.9.8

  • Image fix for some WordPress sites in advanced mode

  • Unresolved issues from 6.8

  • Unresolved issues from 6.8

  • Small fix if someone doesn’t have a LinkedIn company

  • Bug fix

  • Fixed compatibility issue with my other plugin WP Google My Business Auto Publish

  • If you try and share a post with no profile selected we will now display an error message so you know the post hasn’t been shared to LinkedIn and you need to select a profile

  • More diagnostic information collection, better error reporting

  • Fixed content length bug which was solved in version 5.10 but re-appeared somehow. This was causing some users authentication issues

  • Update to redirect URL with better HTTPS/http determination

  • Removed temporary error when authenticating for the first time

  • A new authentication system so you don’t need to create your own app anymore!
  • You can now share to multiple companies and a profile at the same time and selectively choose what profile you want to share to!
  • Heaps of bug fixes and code improvements

  • now loads all styles/scripts locally

  • new SSL mode to assist people with forced SSL backends – please see this new setting under additional options

  • minor bug fix around admin notice message showing error

  • issue with company selection not showing correctly in the plugin settings

  • Better feedback in the plugin settings of the current authentication status of the plugin.

  • A bug caused by LinkedIn is bringing back a share URL which doesn’t work. This update resolves this so the link to your shared post actually works

  • Fixed issue where it appeared as if there was an authentication error when there wasn’t

  • Fixed issue with authorisation code not working due to version 5.18
  • Better debugging or authorisation

  • Removed HTTPS from the redirect URL displayed in the ‘Authorisation Instructions’ to show an HTTP address instead as LinkedIn wasn’t accepting an HTTPS redirect URL.

  • Added new option to not share posts by default in the plugin settings. Thanks Alexander.

  • Fixed diagnostic error message

  • Added diagnostic information to the help tab

  • Added a loading message when clicking a button to prevent people double clicking a button. Thanks skinner009!

  • Enabled the instant share options i.e. the LinkedIn meta box share button and the ‘share now’ link on post listings to share a post even though the category or post type has been blocked in the plugin settings. This enables you to over-ride default actions if necessary

  • Made the plugin translatable and provided some translations

  • Removed shortcodes and HTML tags from post content
  • Fixed plural of day on admin notice

  • Fixed authentication issue some users might have experienced due to LinkedIn requesting a content length in POST requests

  • Fixed admin notice so it now tells you a more accurate message once the authentication has expired

  • Fixed donation link

  • Fixed the way the Redirect URI (which is used in the initial plugin setup/authorisation process) is created and deployed. Now if you change website addresses or go from an HTTP to an HTTPS website the redirect URI will be dynamically created instead of being saved in the plugin settings which was causing some headaches for people. Thanks to Jack Welch for the inspiration to do this fix
  • Tested with WordPress version 4.7.4

  • Limited share message to 700 characters to allow long posts to still be shared

  • Resolved special characters showing incorrectly on advanced share message

  • Resolved fully special characters showing incorrectly

  • Fixes issue with website name and post title showing special characters incorrectly

  • New getting started video which is viewable from the plugin settings

  • Minor change to ‘Share Now’ button

  • Implemented new ‘Share Now’ button on posts page meta box so posts can be shared without having to update/publish the page
  • New smart AJAX post option saving which will give more predictable results when choosing to share, not share or change the custom message of a post
  • Now the ‘Share Now’ button on the All Posts page will actually share the post to LinkedIn rather than taking you to the post edit page to then share the post to LinkedIn

  • Made it easier to reshare previously published posts as you don’t need to make them draft and then publish them again

  • Fixes issue with custom post types being shared to LinkedIn

  • Now works with scheduled posts
  • New help tab to help people with common issues particular as to why posts aren’t being shared on LinkedIn
  • Tested with WordPress version 4.7.2

  • Added notice regarding scheduled posts not working

  • Fixed PHP warning if setting not set

  • Removed ‘Share With’ option because when set to ‘Connections Only’ posts weren’t being shared on LinkedIn – I couldn’t find a solution to this so just removed the option

  • Removed error message created by expiry message if the user hasn’t saved settings yet

  • Fix of advanced option share where the pulling of the title was triggering an error message
  • Added quick settings link on plugin page

  • Now you can share custom post types and pages – check out the new setting in the sharing options tab

  • There are now more more shortcodes to use for the default share message which include the posts excerpt, content, author and the website title

  • Fixed numbering error

  • Updated screenshots

  • Now displays whether a post has been shared with LinkedIn or not on the main posts listing – this can be turned off with a new setting as well

  • Improved logic so that once a post has been sent to LinkedIn the post will default to not sending the post again if updated
  • Added a share history section at the bottom of the meta box on the posts page so you can see if the post has been sent to linkedin before

  • Added clipboard functionality to make it easier to copy redirect url
  • Added admin warning when access token is about to expire

  • Updated links and messaging

  • Updated file names

  • Reconfigured plugin setting arrangement to follow WordPress best practice
  • Updated settings interface

  • You can now choose particular categories not to share on LinkedIn

  • Initial launch of the plugin


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1800 244 735

Helpline (02) 9874 9777

Taking new targets to the bank: the DNA repair protein ‘ATM’ is overactive in Huntington's disease

A recent study by the Yang lab at UCLA points to a new idea for preventing damage to neurons in Huntington’s disease. The strategy is to tone down an overly helpful protein called ATM. Inside neurons, ATM provides a crucial role in repairing the cell’s infrastructure, somewhat like that of a bridge inspector, but the expanded HD protein may be causing ATM to misjudge DNA damage.

Nature’s inspectors, repair team, and demolition crew

ATM actually has nothing to do with a bank machine. ATM is an abbreviation for ‘Ataxia Telangiectasia Mutated’ because it is a gene that can cause a movement disorder called Ataxia Telangiectasia, but it may also play a role in Huntington’s disease.

The function of ATM in the cell is something like a building inspector. When bridges get old they often rust, and parts need to be replaced to keep roads safe. Most bridges are inspected at least once a year by intrepid engineers with climbing equipment who determine whether or not a bridge can be repaired, or will need to be condemned.

Inside our cells, DNA shows wear and tear with age too, developing cracks and even breaks in the structure. This DNA damage occurs as part of the normal aging process, but it is seen earlier than expected, or more often than expected, in Huntington’s disease patients. DNA damage is also seen in HD cell and animal models.

The job of the ATM protein is to detect this sort of DNA damage, and then hang around the damage site, calling in a team of specialized proteins to do the repairs. If the damage is too great, ATM activates a different set of proteins, a sort of demolition crew, which condemns and removes the cells harboring the damaged DNA. It is a tricky business—an overzealous inspector could actually condemn a structure prematurely, while an unobservant inspector might fail to detect and repair structural damage.

Making the right call

Actual bridge inspectors usually communicate with their teams via walkie-talkie. In cells, communication is done by fastening chemical tags known as phosphate groups to the right proteins. ATM calls in the repair team by ‘phosphorylating’ a protein called H2AX. H2AX then settles down at the site of the structural DNA break and gets the repair started. If the damage is too far-gone, ATM can phosphorylate a different protein, called p53, which brings in the demolition crew instead of the repair team. The demolition crew shuts down the entire cell in a process called apoptosis, or programmed cell death. Needless to say, a lot of problems can arise if the demolition crew is called in by mistake.

The work done in the Yang lab shows that ATM signaling is increased in Huntington’s disease, and this signaling may be going awry. When cells with the HD mutation were stressed, they showed more H2AX phosphorylation, and more cell death than expected. Excess H2AX phosphorylation was also found in brain tissue from HD patients, especially the portions of the brain that are known to be vulnerable in HD.

The question is whether extra ATM signaling in HD is a good thing, or a bad thing: in vulnerable brain regions, HD might cause more DNA damage, so ATM might be doing the right thing by signaling H2AX to make repairs. On the other hand, if overzealous ATM signaling is one of the detrimental effects caused by the expanded HD protein, then it could make a good target for a potential therapy.

Less is more

ATM is essential to normal health—patients with mutations in both copies of their ATM gene have a serious disorder called Ataxia Telangiectasia. Yet having only one functional copy of the ATM gene, a half dosage, doesn’t seem to cause any symptoms at all.

With this in mind, the Yang lab set out to study ATM signaling in several ways. They started by reducing the amount of ATM produced in HD cells grown in a dish, and found that blocking ATM signaling actually made the cells healthier. Somehow, ATM signaling may have been calling in the demolition team rather than the repair crew in the HD cells.

The research team then looked at fruit flies with the HD mutation, which have trouble with their coordination when climbing up test tubes. They generated HD flies with a half dose of ATM (only one copy of the fly ATM gene). These flies were much better climbers than the regular HD flies.

Finally, when the researchers bred ‘half dosage ATM’ mice with HD mice, they found the most convincing results of all—the HD mice appeared healthy! HD mice with reduced ATM moved better, showed fewer signs of depression, had fewer aggregates, and less brain atrophy than the HD mice with normal amounts of ATM. In other words, having half of the normal ATM prevented some of the problems caused by HD.

Taking the ATM target to the bank

It is possible to reduce the activity of ATM with a small molecule drug, called an inhibitor. The researchers put ATM inhibitors on neurons grown in a dish and they found that it protected the cells from damage done by the HD protein. This opens the possibility for the development of an ATM inhibitor medication to treat HD.

At this point, we don’t know how the HD protein causes abnormal ATM signaling. But two other studies have noticed the same thing, and this type of independent replication goes a long way to boost our confidence that we’re on the right track. Together, the results of these studies suggest that reducing ATM may be a promising new way to treat HD, and perhaps to prevent damage caused by the HD mutation.

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Latest Research Articles

Updates from the EHDN Plenary Meeting 2020

Published date: 9 October, 2020

In September, the European Huntington’s Disease Network (EHDN) hosted a virtual webinar event which comprised presentations on some of the latest scientific research as well as clinical studies of Huntington’s disease (HD). Researchers, doctors, patients and other interested folks, tuned in for an afternoon of talks as well as question and answer sessions to learn ... Read more Updates from the EHDN Plenary Meeting 2020

Sad news from the SIGNAL study: pepinemab does not influence HD symptoms

Published date: 23 September, 2020

The SIGNAL clinical trial was designed to test a drug called pepinemab in people with early Huntington’s disease. The key results of that trial were recently announced, and unfortunately, pepinemab did not slow or improve HD symptoms as hoped. What was the SIGNAL trial, and who participated? The SIGNAL trial was launched in 2015 by ... Read more Sad news from the SIGNAL study: pepinemab does not influence HD symptoms

When genes are unstable: targeting somatic instability in HD

Published date: 8 September, 2020

What is somatic instability? We tend to think of DNA as a fixed blueprint, an overarching plan for the biological bricks and bridges that constitute our cells, organs, and bodies. But like any good plan, DNA is actually dynamic and adaptable. It gets frequent use as a template for creating the RNA messages that pave ... Read more When genes are unstable: targeting somatic instability in HD

Working as a team: Changes in brain development mean some brain regions may be slacking off

Published date: 17 August, 2020

The effect of the HD genetic expansion on brain development has been a hot topic in HD research. A team of researchers led by Dr. Sandrine Humbert at the Grenoble Institut Neurosciences, examined human fetal tissue to show that the mutant HD gene causes very early changes in the patterns of early brain development. But ... Read more Working as a team: Changes in brain development mean some brain regions may be slacking off

Caution urged for the use of gene-editing technology CRISPR

Published date: 12 August, 2020

A gene-editing tool known as CRISPR has been heralded as a breakthrough technology for scientists in the lab but also as a potential strategy to treat numerous genetic diseases, including Huntington’s. But a series of recent studies has suggested that CRISPR is less precise than previously thought, leading to unintended changes in the genome. Three ... Read more Caution urged for the use of gene-editing technology CRISPR

HD and Histamines: Targeting Hybrid Receptors to Quiet Stressful Brain Talk

Published date: 15 July, 2020

Dopamine is an important chemical messenger in the brain that becomes imbalanced in Huntington’s disease. Researchers recently described a creative way to restore the balance and treat symptoms in HD mice, using an antihistamine drug that acts on hybrid dopamine receptors. It’s an innovative approach to HD therapeutics, but don’t start reaching for allergy meds ... Read more HD and Histamines: Targeting Hybrid Receptors to Quiet Stressful Brain Talk

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Mind Your Weight

Curb cravings,  Control appetite,  Eat artfully,  Motivation to exercise,  Outer space body shaping,  Control centre of the brain to boost metabolism,  Learning to accept yourself,   Overcome psychological barriers,   Freedom from unwanted compulsive behaviours,  Taking the path of excellence

*INSTANT DELIVERY – NOTE: A pdf is delivered immediately after purchase which contains instructions for getting the audio MP3 downloads for immediate delivery worldwide

The Hypnosis Support To Advance Control of Your Body Shape and Reduce Weight

Why Mind Your Weight Will Work When So Many Other Approaches Fail

This is an introduction to Adam Eason’s latest audio programme which is an evidence-based set of hypnosis sessions entitled ‘Mind Your Weight’  The audios help you to deal with the really challenging aspect of controlling your weight – the mental, an emotional and motivational mindset that is necessary if you are going to maintain a healthy eating and exercise regime.

Does it eat you up inside every time you wake up in the morning, look in the mirror, and see the reflection of a body you can’t wait to cover up with loose clothing to disguise the bulges you wish weren’t there.

I’ve worked with many individuals in my therapy rooms and those people have been there too.

Many people were thin in their teens but as they approached adulthood took on some bad habits and started a battle that never seems to go away with an

up and down
out of control
weight yo-yoing issue

Your Resolutions

Have you like many others, taken up a resolution to sort this out once and for all.

You probably start off full of drive and excitement, and make good progress on your goals for 2 or 3 weeks, but then – life gets busy, you get distracted and your New Year’s resolutions get dumped in the too hard basket.

And to make matters worse, there’s always that one person who keeps asking you how your resolutions are going, and you know they’re having a good old laugh at your expense.

You feel trapped inside a body you’re embarrassed of, concealing it with dark coloured baggy clothes, or worse, you make up excuses to avoid catching up with friends because you hate the way you look, and you let life’s most fulfilling experiences pass you by.

Yes – the time is passing you by and you are fully aware that you have only one shot at life.

You’re aware – you know what you should do – but it is just too hard to do.

You need HELP!

And it’s not for lack of trying, it’s just that exercise boot camps and crazy diets never seem to work – or at least if they do then the solution is short-lived and before you know it – here we go again the weight is back  – AND some…

There are so many so-called solutions in magazines, on the TV, on the internet, radio and newspapers.

All very confusing, contradictory and often controversial.

The big problem with these extreme approaches is that they are impossible to maintain and they make you feel downright miserable.

The fact is, none of these quick-fix gimmicks equips you with the mental and emotional tools you need to build good habits and STAY motivated and driven to keep the weight off…

And this is why I’m so excited to be able to share with you today my new audio programme which you can download right now.

This Mind Your Weight Audio Programme.

It’s called “Mind Your Weight – The Hypnosis Support To Advance Control of Your Body Shape and Reduce Weight”.

My Name is Adam Eason, a UK Hypnotherapist.

Over the last 20 years, I’ve personally seen hundreds of people one-on-one in my consulting room to help them achieve the body they desire.

Men and women, young and old, and all body types – I’ve seen it all.

In my new audio “Mind Your Weight”  I introduce you to a set of hypnosis sessions that quite literally will change your life if you use them regularly and in conjunction with a comprehensive plan of healthy eating and regular exercise.

What my audios WILL DO is provide the hypnosis for the hard part – the change in mindset that will be required to break the bad habits and get on that good wave of motivated flow.

Old habits such as –

  • snacking on junk food
  • eating excessive portions of food
  • binge drinking
  • lack of exercise or
  • lack of motivation to exercise.

I break it down for you into bite-size bits chunks (pun intended), and using hypnosis, take you on a step-by-step journey showing you how to reset your mental programming, and transform your negative emotions into a steam train of enthusiasm that’ll help you sustain your motivation and drive throughout.

What makes this audio programme different from any other weight control programme is that it is an evidence-based approach too.  All the audio tracks have either evidence to support them directly or the underlying evidence support them.

Your Mind is at the Centre of the Solution.

It is psychology applied to control the most important organ in your body – your brain – and it’s therefore central to helping you succeed in the long term.

“Mind Your Weight” covers the physical, mental, emotional, AND social aspects of weight gain.

 Let me show you exactly how to Mind Your Weight works

The first thing you will need to do is download the files to your laptop or mobile device.

Included is an introduction to hypnosis and a practice hypnosis session to familiarise yourself with the processes if you have never been hypnotised before.

[Remember the more you practice hypnosis and self-hypnosis processes the better you will get at them.]

You will need about 20 minutes for each hypnosis session and a place where you are unlikely to be disturbed.

Then you get yourself sat down in a comfortable position and listen to the first part of the “Mind Your Weight” programme.

The first six audios are narratives that build a solid foundation of belief and diligent planning in an evidence-based fashion before the all-important 10 hypnosis tracks that follow –

That’s it.

Listen and follow my instructions about how to listen to the audios and you will notice yourself achieving the size and weight that pleases you.

How much easier can it be to change your life completely?

Here’s exactly what you’ll get access to when you download this product today:

Narrative introductions examining your beliefs, some problem-solving techniques and strategies and some instructions to set things up for the hypnosis sessions:

  1. Curb cravings.
  2. Control appetite.
  3. Eat artfully.
  4. Motivation to exercise.
  5. Outer space body shaping.
  6. The control centre of the brain to boost metabolism
  7. Learning to accept yourself.
  8. Overcome psychological barriers.
  9. Freedom from unwanted compulsive behaviours.
  10. Taking the path of excellence

Points I would like to make:

  • Relying on your willpower to make the weight control changes you want is a guaranteed recipe for failure.
  • Hypnosis can ignite a raging fire of motivation in your belly that will compel you to take massive action on your goals.
  • All you have to do is have the desire to control your weight – read up on good nutrition and exercise – then this hypnosis programme is going to deliver the rest. That’s it.
  • Hypnosis will help you stop emotional eating once and for all
  • Hypnosis enables you to channel the miraculous power of belief to destroy self-doubt.But don’t just take my word for it –

Here’s what a former client has had to say about this programme which has been updated here as ‘Mind Your Weight’

I wasn’t excessively overweight — but I wasn’t happy with the ‘spare tyre’ I had developed and the way my weight was gradually creeping up.
The problem I had was resisting tempting snacks, cakes and chocolate.  Your programme helped me to control those cravings and the pounds started to fall away.
I’m well on the way to my ideal weight, thanks to you Adam.
Carol Bentley. Swanage, UK

Now you may be asking yourself how much “Mind Your Weight” that delivers this much value is going to be.

And that’s a fair question given that my services as a one to one hypnotherapist start at £200 an hour… and I see clients for an average of four to six sessions.

However, the reason I created the online version, this downloadable version of “Mind Your Weight” is to make this life changing information available to everyone who wants to break free from the depression of endless roller coaster weight fluctuation and instead achieve a body to be proud of – FOR THE LONG TERM.

This means that in just a few moments from now you could be using “Mind Your Weight” to get lifelong control of your weight. And all for a ridiculously low £19.77

So here’s what you need to do now: To order your copy of “Mind Your Weight”, just click the “Add To Cart” button that you’ll see on this page.

And I’m so confident that these hypnosis techniques and the other strategies in this audio programme will work for you, that if you follow them as I’ve outlined them for a year, and you don’t reach your goal within that first year, just send me an email and I’ll refund you the full purchase price, no questions, no hassles.

AND you can keep the audio as my gift to you.

Stop The Struggle

Look, you’ve struggled with your weight for long enough.

Right now you can put an end to the emotional eating, low self-esteem, and social isolation that has deprived you of the life you deserve.

Just imagine how you’ll feel when you get out of bed – look in that mirror and nod (and I am sure you will also smile knowingly) with approval at what you see.

So grab your copy of “Mind Your Weight” now and discover the secrets of the body you’ve dreamed of today!

I look forward to hearing about your success.

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This weekend was full of surprises!

Last Tuesday, I started developing symptoms of COVID-19 and I immediately became incredibly angry. Not only was I forced to postpone my trip home to see my family, which I've been excited about for months (I haven't seen them since Christmas!), but I also knew that I would have to miss an important class at my gym on Saturday morning. Professor Daniel Wanderley was making a trip from Wisconsin to teach a special two-hour Brazilian Jiu Jitsu class, something that typically only happens once a year. I was devastated.

Lucky for me, my coach allowed me to watch the class via Zoom. I was THRILLED! Whenever Professor Wanderley comes to town, it means that people at the gym will be receiving belt promotions, which is a big deal. I really didn't want to miss seeing my teammates move up the ladder, so I was excited when the laptop that I was on was placed up at the front of the class. I thought that was done so that I could see all the action, but it turns out there was another motive.

After watching a few of my very deserving teammates get their blue belts, I was awarded with mine. I couldn't BELIEVE it! I didn't know that it was possible to get a belt promotion virtually, but I guess these are the times we are currently living in. It was such a wonderful surprise that I broke down into tears. After a terrible week full of terrible news, I was so overwhelmed with gratitude that I cried over and over all day long. I might be the only person to ever be diagnosed with coronavirus and given a blue belt in the same day!

Jiu Jitsu has been a big part of my life these past few years. When I started back in November of 2017, I had no idea what I was getting myself into. Nobody, not even me, thought I would last the week, but here I am almost three years later. Not only has it made me stronger, but it's given me confidence, it's significantly helped my anxiety, and it's given me a family of wonderful people that I probably would've never met otherwise. I have many years of Jiu Jitsu ahead of me and I can't wait to see where this journey takes me!


text:
Stuart Wilson Web Developer

Creative and forward-thinking London based web developer with over 6 years of agency and in-house experience. I’m passionate about building great user experiences through collaborative working while promoting code reuse and sustainability.

Contact me via email or check out my open source work on GitHub. I occasionally post on Instagram about code, cycling and life.

Download CV

Head of Front End Development Catch (Oct 2015 - Present)

At Catch I’ve been instrumental in driving the tech credentials of the agency forward through the applied introduction of modern web technologies and standards. After joining as a Front End Developer I was quickly promoted to Head of Front End Development, where I have been responsible for mentoring other developers, driving change and unifying our approach to reduce internal technical hurdles and drive development phases at a quicker pace.

Key Clients: Zoological Society of London / SES / Worldpay / Institute of Physics / Cancer Research UK / Thomas Cook Airlines

Front End Developer graze (Aug 2014 - Oct 2015)

Whilst at I was involved in rewriting and implementing the Pistachio pattern library as part of a team whilst modernising the website’s JavaScript using CommonJS modules and Browserify. My day to day duties included developing the website UI to support commercial projects whilst focusing on code modularity, reuse and scalability in an agile team of software developers.

Lead Developer eight&four (Aug 2012 - Aug 2014)

Joining eight&four as a Junior Developer, I moved quickly within the agency to establish myself as the Lead Developer. Heading up the technical output of the agency, my main responsibilities included developing, testing and deploying primarily WordPress built websites. Other responsibilities as the senior developer on the team involved scoping out new projects with clients, writing technical specifications and bringing technical innovation to the agency.

Key Clients: RSPCA / Solarcentury / Healthcare International / Freesat / Echo Falls / Cosmopolitan

First Class Honours Degree (BSc) in Media Technology Oxford Brookes University (Graduated June 2012)

A Levels: Art, Media Studies, English Language Peter Symonds College, Winchester

GCSEs: 10 Grade A* - C Henry Beaufort School, Winchester


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IAT ENGINEERING & DESIGN is a private limited company, established in 2010, with the mission to become a leading engineering company in Romania, by permanently identifying the customers’ needs and offering the best solutions to match these needs.

The company is dedicated to provide the technical services for the oil & gas industry, implementing the projects in accordance to the customers’ philosophy.

Keys to Success

  • high - skilled professionals, with great expertise in managing projects in the oil & gas;
  • excellent experience with complex projects;
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  • a large relationships network on the local market;
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  • a strong organizational culture, focused on teamwork and business ethics;
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Category: Classic Rock

Your Time In This Life Is Just Temporary

Aug 08,  · During the time of Jesus’ earthly ministry, He spoke often that He’d come from Heaven to redeem the lost and that He’d be killed as a ransom for their sins, and that He would make a home in Heaven for those who accept Him and love Him. The actual phrase that you’re referring to is a conclusion that Christians bring forth to emphasize.
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I build my ideas #3 - 06/14/20

Introducing lil APIs, iMessage ideas, Apple archive, You App

Introducing lil APIs

A friend was building GraphQL APIs that were similar in spirit to lil apps: ultra simple and utility-based. It occurred to me that lil software makes lil apps, but what if lil software made lil APIs too?

What if the same APIs that power lil weather and lil news were exposed for anyone to use? And what if they were super simple, just visit an API endpoint and it works - do whatever you want with it.

Introducing lil APIs, ultra simple utility-based APIs for you to build on. They’re the same exact APIs that power lil weather and lil news. Just add water ™

iMessage ideas

I realized that whenever an idea comes to mind, I’ll run it by a few friends to do a gut check and make sure I’m not crazy. The conversation gets other ideas flowing and usually excites me further to make them real.

I picked up on the fact that I generally pursue these ideas to at the very least visualize them. Whether that’s seeing them mocked up in Figma all the way through to building them so that they come to life. Check out that thread above for a few examples. It’s the same way that lil APIs started!

Apple archive

I’ve become obsessed with buying old Apple products on eBay that I used to own or was in awe of as a kid.

Over the past year I’ve been gradually building up my collection:

  • Original iPhone, iPhone 3G, iPhone 4, iPhone 5, iPhone 7 Jet Black

  • Original iPad, iPad 4

  • Original MacBook Air, MacBook White Unibody, Black MacBook

  • iMac G3, iMac G5

  • iBook G3 clamshell

  • iPod Classic, iPod Nano 1st, 3rd & 4th gen, iPod shuffle 1st, 2nd & 3rd gen

  • iSight camera

These are all mostly just lying around, and every once in a while I’ll take them out to reminisce over iOS 6 or Mac OS X Snow Leopard. I’m not sure what my plan is with them long term, but it’s a fun hobby!

You App

Buckle up.

I had this crazy idea with some crazy inspiration (back at it again with the iMessage ideas).

I saw this “Step Chickens” thing being discussed all over Twitter, but in particular how this app had been repurposed to focus on a single person, with a person’s picture as the app icon.

It occurred to me: “what if people had their own apps?” Wait what? What does that mean? How would that work? Everything was centered around this visual of peoples avatars on app icons. I became fascinated by this.

Combine that thought with what I had seen from Clubhouse and some other TestFlight apps:

At first it was very abstract, but the more I started to think about it the more this thought started to feel like it could become real. Fair warning - this is super super experimental and early on, but here’s the working idea at its core:

Imagine the You App as an App Store for people and where you can build your very own app. Everyones You App is the same - an app where you can build your own community and following. Almost as if you’re building your own social network centered entirely around you.

People as apps is a novel concept that was hard for me to grasp at first, but here’s how I personally think about it: Twitter is a singular app where everyone has their own profiles inside of it. You play by Twitter’s rules and are subject to their roadmap. Imagine taking your Twitter profile but giving it its own app - your You App.

Take the Jordan app as an example. You could download my app and join my community/following and see my posts. You could post to it yourself - questions, thoughts, ideas. Anyone could reply in the comments, like posts, etc. It’s just a community/social network around a singular person all packaged up in your very own app.

There are a number of challenges here, particularly around scalability. In order to get separate apps up and running for people, even on TestFlight, involves a bit of manual work. There’s also the concern around if Apple would accept these in the first place. I’ve had my fair share of running into trouble with Apple in the past.

I’ve taken an interesting approach to distributing You Apps for people that (ever so slightly) eases the burden on me: each You App uses the same exact code base, with only a few tweaks per app for the app icon, app name, and getting the server to talk to the right person’s app. But updating them, maintaining them, etc is a scalability concern and sounds hard.

Like with most ideas I pursue, I’m gonna start small with this one and see where it goes and how it evolves. I really think there’s something novel and unique and interesting around the idea of people as apps - and I want to keep going until I reach a dead end.

Follow You App on Twitter for early access

Check out the latest Recreate post: Recreating the Instagram home tab

Check out the latest Cash App Figma plugin: Live Preview

Cash App is hiring designers!

Ask me anything


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Antonelli’s new Raclette Night at Home! Looking to make dinner a little more fun and interactive? Or perhaps you’re looking for a special way to celebrate with your quarantine pod.  What’s better than melting and scraping over 3 lbs of cheese onto your plate of potatoes, pickles, and cured meats for just $175, including the melting machine!?!? You can rent it any day of the week! Get more details – and start reserving – here.

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