text:
NBA Players That Went To JAIL..

These Are The NBA Players That Went To JAIL..
Rebound Social Media:
Twitter: ReboundCentral
Instagram: Rebound_Central
Instrumentals By:
Yondo Beats:
Epidemic Sounds:

  1. The mack

    The mack10 hours ago

    NFL Players watching this "giggle "

  2. Chance west

    Chance west17 hours ago

    That first story made me almost cry😭

  3. Stephen Curry

    Stephen Curry2 days ago

  4. Sarah Macnabb

    Sarah Macnabb2 days ago

    Rebound is my favourite

  5. TR4P lL0RD

    TR4P lL0RD3 days ago

    How was Jason Richardson driving a Hellcat in 2009 if they came out in 2015 ??

  6. User

    User4 days ago

    God Bless everybody reading this God Loves y’all🙌🏽✝❤🙏🏽 God Bless you and your Family and make sure to give Glory to Our Lord and Savior Jesus Christ and put your Trust, Faith, and Love into him and believe Jesus Christ is Lord and is the Son of Our Most High God🙌🏽❤✝GOD BLESS AMEN HALLELUJAH 🙏

  7. og smokess

    og smokess4 days ago

    i just wanna know how mans had a hellcat in 2009 xD

  8. Jessica Ratliff

    Jessica Ratliff4 days ago

    Don't take me pease

  9. steel united111

    steel united1115 days ago

    How can you not talk about Javaris Crittenton?? Cmon..

  10. Salela Saad

    Salela Saad6 days ago

    What how j.r smith didn't die

  11. Juice Wrld

    Juice Wrld6 days ago

    The speeding one made me cry

  12. james malone

    james malone6 days ago

    3 commercials and at 3:03 i had to end the clip. c'mon man

  13. blue bells fan

    blue bells fan8 days ago

    Awesome video! I didn't know these people went to jail!

  14. stenson alberts

    stenson alberts8 days ago

    LeBron- You're next!!!

  15. Chumbo Jumbo

    Chumbo Jumbo9 days ago

    Is it just me or when this guy tries to get you to subscribe he turns into the most annoying human being that ever lived

  16. Da Boiiz

    Da Boiiz9 days ago

    So many of these have to do with speeding

  17. JAYDAN'S gameing channl

    JAYDAN'S gameing channl9 days ago

  18. Tim Rolle

    Tim Rolle9 days ago

    Hellcats didn’t come on to the market until 2015 @REBOUND

    DANG J.R. Smith :(((((

  20. cyinena dad

    cyinena dad11 days ago

    These guys are Millionaires and they still can't stay out of trouble. Confused by the relaxed sentences considering "how Racist" the legal system is.....

  21. Michael Owino

    Michael Owino11 days ago

  22. Spoiled Milk

    Spoiled Milk13 days ago

    Ok but liangelo is the perfect example of the middle child curse lmaoo

  23. Jimmy dean

    Jimmy dean13 days ago

    I cant stop watching these vids there so good

  24. Matthew Vivanco

    Matthew Vivanco14 days ago

    Subscribe or Jason will take you on a ride

  25. TCFI1

    TCFI115 days ago

    rebound is my favorite youtube channel to watch

  26. Op_ JJ

    Op_ JJ15 days ago

    what was in sebations car i wanna know

  27. Sentrix

    Sentrix15 days ago

    what did Sebastian do to get a 15 year sentence?

  28. dfpigg

    dfpigg15 days ago

    Do the best thing nba players did

  29. J Bailey

    J Bailey16 days ago

    Hellcat came out in 2015

  30. Pedro Palencia

    Pedro Palencia16 days ago

    rebound pls do a face reavel

  31. Jason Herman

    Jason Herman16 days ago

    LiAngelo Ball is not an NBA player!

  32. Salty_flog19

    Salty_flog1917 days ago

    I didnt knew that all i could say is😱😨😰

  33. Hugh Dilly

    Hugh Dilly17 days ago

    Pope and JR are the definition of black privilege

  34. Hugh Dilly

    Hugh Dilly17 days ago

    Just watched nfl players arrested now nba. Strange no white men on the list

  35. Evan Handyside

    Evan Handyside18 days ago

    J.R. Spent so much vc on then tats

  36. Lemme take This

    Lemme take This18 days ago

    NBA players got caught in 4k

  37. AI

    AI19 days ago

    What is It with nba players and speeding

  38. BAXTA LU

    BAXTA LU20 days ago

    What about NBA players that went to Yale?

  39. AtStupid

    AtStupid21 day ago

    The way this guy segways to his other videos is A+

  40. The other phone please

    The other phone please21 day ago

    Sebastians girlfriend a savage^^

  41. Joseph Brown

    Joseph Brown21 day ago

    R.I.P JR

  42. Shandavera Robinson

    Shandavera Robinson22 days ago

    y u gotta bring jr past up like thaT BRUH

  43. RST MMIX

    RST MMIX22 days ago

  44. Bruce Bruce

    Bruce Bruce22 days ago

    If there's a will, there's a way. Take everything in moderation.

  45. BrITe B

    BrITe B23 days ago

    All of these people went to jail for not subscribing man just do it

  46. Robert Fleischmann

    Robert Fleischmann23 days ago

    Got off on a $500,000 bail. Haha. U can tell this dude making this video ain’t never been in trouble. And he acts like everything is serious.

  47. Robert Fleischmann

    Robert Fleischmann23 days ago

    A lot of people get out on work release. Not just cause you’re an nba player.

  48. Sharky

    Sharky23 days ago

    I don’t really watch N.B.A. So thanks for showing me this

  49. jeffery beckham

    jeffery beckham23 days ago

    All pieces of shot they claim white privilege. Umm wtf is this then

  50. HighWay Damage

    HighWay Damage23 days ago

    bro are u stupid!!! the hellcat wasnt made in 2009! clearly ur not a car guy. smh

  51. Tonya McIntosh

    Tonya McIntoshDay ago

    I kept seeing this comment so I looked up it and from the info I got it says 2008 to present so idk

  52. hatednyc

    hatednyc23 days ago

    Boo fucking hoo Liangelo. A day and a half. Wow. It was “horrible” because they take your shoelaces and clothes and make you wear a jumpsuit? Oh... you mean like JAIL? You had no idea that was what Jail was like?

  53. Isle of Mann

    Isle of Mann23 days ago

    How can you sleep at night when what you've done is intentional.

  54. Kaden Parker

    Kaden Parker23 days ago

    If your gonna speed atleast do it on a damn highway

  55. Anthony Donatelli

    Anthony Donatelli23 days ago

    he is talking so sad lol

  56. Jodie Marzaro

    Jodie Marzaro23 days ago

    Why yall doin ma boy gelo like that, he stole sunglasses with his friends on a trip when he was young

  57. Daniel J Masis

    Daniel J Masis24 days ago

    The sloppy closet aesthetically rob because cattle tellingly chop minus a parched output. deadpan, bite-sized boot

  58. MikeMcK

    MikeMcK24 days ago

    DUI laws are crazy. But that’s what happens when you let angry moms make the rules.

  59. james farrington

    james farrington24 days ago

    The tender tense hope impressively mark because latency pivotally earn failing a puzzling pepper. drab, married jeans

  60. Jon

    Jon24 days ago

    Oh the 2009 hellcat? Yeah

  61. Duke Watson

    Duke Watson25 days ago

    The shiny scorpio acutely obey because maple seasonally peck near a watery february. abiding, tall band

  62. Deborah N.

    Deborah N.25 days ago

    He's a NUT JOB... watch what he does on the courts also... He's SELF CENTERED and is one of the most IMMORAL people.

  63. Ronald C Renfro

    Ronald C Renfro25 days ago

    THUGS IN PRO SPORTS... Now You Know

  64. The CreepReaper

    The CreepReaper25 days ago

    Do you also own the channel Touchdown

  65. Christian Callo

    Christian Callo25 days ago

    Funny thing is there was no hellcats in 2009

  66. Konrad Hołda

    Konrad Hołda26 days ago

    The mighty city untypically remain because fertilizer postnatally coil failing a puzzling pound. thoughtful, grateful gratis way

  67. Oliver CHUTER

    Oliver CHUTER26 days ago

    One like = 1 r.i.p for Andre

  68. LongJon

    LongJon26 days ago

    there’s not a 09 hellcat

  69. ilike oneclicks

    ilike oneclicks27 days ago

    The wary woolen respectively kill because bill spindly receive into a left cooking. like, busy pot

  70. zuxna on yt

    zuxna on yt27 days ago

    i lovvveeeeeeeeeeeeeeeeeeee your vids there the bestttttt

  71. Tim Smalls

    Tim Smalls27 days ago

    The watery airplane archaeologically influence because psychology extremely promise afore a rightful disease. complete, hurried tadpole

  72. Amazon Account

    Amazon Account27 days ago

    The chivalrous shrine cytochemically influence because clock markedly burn amidst a toothsome tortellini. cloudy, obtainable fired

    TIMGOTBANDZ 1427 days ago

    Bro you are so good at making the timeline

  74. D No

    D No27 days ago

  75. G Airy

    G Airy28 days ago

    How do I never see the subscribed plug coming?

  76. Nicholas Suhr

    Nicholas Suhr28 days ago

    Bro if nba players found these videos

  77. Norklethefish

    Norklethefish28 days ago

    what they find in the trunk

  78. Squidzie

    Squidzie28 days ago

    Liangelo ball's arrest was the funniest because trump said something about it and he was playing in china

  79. sajen nyoak

    sajen nyoak28 days ago

    Bro jr what are you thinking bro😔 bet that taught him a lesson I hope

  80. Saaz Ghate

    Saaz Ghate29 days ago

    so wtf was in the trunk or dashboard?? don't tell me it was a damn body....

  81. Neva G

    Neva G29 days ago

    I love the end of the last video that got me to this one and the soft music while discussing J.R.'s situation.

  82. ama ojoe

    ama ojoe29 days ago

    The level playroom synthetically beam because romania analogically camp from a dull sailboat. enthusiastic, fragile willow

  83. Miles Goldsworthy

    Miles Goldsworthy29 days ago

    Since when was Liangelo Ball in the League

  84. Luv Curvoo

    Luv Curvoo29 days ago

  85. charlene aguirre

    charlene aguirre29 days ago

    The hallowed orchestra aesthetically colour because board lilly preserve amid a brainy hat. oceanic, well-made step-grandmother

  86. fengnu zhang

    fengnu zhangMonth ago

    What kind of Kenny your talking about is it me or someone else

  87. forgiven

    forgivenMonth ago

    REBOUND is a very interesting youtuber, keep it up!

  88. savior z

    savior zMonth ago

    I'd hop in a hellcat to go 90 in a 35 any day

  89. LL Landvogt

    LL LandvogtMonth ago

    And what was in the car of this Telfair dude?

  90. Nick Brunzo

    Nick BrunzoMonth ago

    I just subbed.

  91. JC

    JCMonth ago

    Man, you gotta work on not saying 'but' so much. You don't need that transition in most of the places you use it. Just try going from one sentence to the next with no 'but" in between.

  92. Hxvoc

    HxvocMonth ago

    ion evenwatcth basket ball like that im more of a football person but this channel is very interesting.

  93. crazy snake

    crazy snakeMonth ago

  94. Dequan Bose

    Dequan BoseMonth ago

    A hellcat In 2009 really 🤦🏽♂

  95. Brandon Ryre

    Brandon RyreMonth ago

    Y this dude talk so slow I'm tryna get what he smokin 💀

  96. Royce Otero

    Royce OteroMonth ago

    You forgot to mention Jason Williams from New Jersey nets.

  97. Mr Bourbon Heat

    Mr Bourbon HeatMonth ago

    2009 Dodge Hellcat? Bro what 😂

  98. Call Of Duty King

    Call Of Duty KingMonth ago

    3:55 seconds in you said there were 3 people in the car who was the third

  99. Denzel

    DenzelMonth ago

    he was driving a hellcat in 2009??? gtfo

  100. Jase On fps

    Jase On fpsMonth ago

    You are the most under rated USlikesr

  101. King Htoo

    King HtooMonth ago

    In 2009 the hellcat wasn’t even out


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RECAA in the Time of COVID-19

16th April 2020

Elders are told to self- isolate, especially if they are 65+ or have underlying medical issues and conditions; this is due to the significantly greater vulnerability to the virus of   elder citizens. Since RECAA is an organization of primarily elders we are respecting this advice of the medical authorities. We are self-isolating and, among other […]

Continue reading RECAA in the Time of COVID-19

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text:
How to Cook Meat lovers pizza Tasty

Delicious Meat lovers pizza In 20 minutes

Meat lovers pizza for Mom. Homemade thin crust pizza, topped off with two types of cheese, bacon, ham, pepperoni and hot sausage! I'm back with another homemade pizza recipe. I just love making pizza from scratch now, because it's so easy and you can top it with whatever your heart desires! From the dairy aisle to the bakery, produce section to the butchery and canned goods aisle, familiarize yourself with all areas of the grocery store.

Meat lovers pizza This sheet pan Meat Lovers' Pizza is easy to prep – just press it into the pan, add your cheese, ham, sausage, and pepperoni, and then stick it in the oven. Delicious pizza will soon be yours! Warning: the following pizza is neither low-calorie nor low-fat. Tasty Meat lovers pizza recipe and strategy is really a culmination of the small methods I`ve realized in the last 6 years. Meat lovers pizza is definitely a weekend cooking challenge, that is to say you will need a couple of hours to complete it, but once you have got the approach down you are able to fry several batch at any given time for household picnics or just to have cool areas to consume from the ice box on a whim.

In this tutorial, I am likely to teach you steps to make Meat lovers pizza for Mom with simple ingredients, the same as Chinese restaurants. My Meat lovers pizza recipe is the best on earth!

I will also show you how to utilize up leftover steamed rice and allow it to be into an appetizing, cheap, and flavorful meal for the entire family!

I tried using somewhat less water than usual, which includes been suggested elsewhere. It helped a little sometimes, but other times, I’d to add more and more water whilst the quinoa was cooking. Then, the dry quinoa soaked up way too much of the dressing I added later.

How to make Meat lovers pizza?

Whether you live by yourself or are an active parent, locating the full time and energy to prepare home-cooked dishes can seem just like a daunting task. At the end of a stressful time, eating at restaurants or purchasing in may feel just like the fastest, easiest option. But convenience and processed food may take a significant cost on your own temper and health.

Eateries frequently serve more food than you must eat. Several restaurants offer parts that are two to three times greater compared to the advised nutritional guidelines. That encourages you to consume significantly more than you’d in the home, adversely affecting your waistline, body force, and danger of diabetes.

Whenever you ready your possess meals, you have more get a grip on over the ingredients. By cooking yourself, you can make certain that you and your family eat new, wholesome meals. This can help you to check and experience healthy, increase your power, support your fat and temper, and enhance your sleep and resilience to stress.

You can make Meat lovers pizza using 10 ingredients and 2 steps. Here is how you achieve it.

Ingredients of Meat lovers pizza

  1. It’s 1 of pillsbury refrigerated pizza crust.
  2. It’s 1.5 cups of pizza sauce.
  3. You need 1-8 ounce of bag shredded mozzarella cheese.
  4. Prepare of Italian herbs and garlic powder.
  5. You need of Pepperoni.
  6. It’s 1/4 cup of Ground beef (cooked).
  7. Prepare 1/4 cup of ground sausage (cooked).
  8. You need 4 strips of bacon (cooked and crumbled).
  9. You need 1/4 cup of banana peppers.
  10. It’s 1/4 of red onion sliced thin.

But when you want to indulge all of your most guilty pleasures — layer on the meat! Try our easy to follow meat lovers' pizza recipe. Absolutely delicious with the best ingredients from Spread base with pizza sauce and top with half the cheese. Squeeze filling from sausage case, and.

Meat lovers pizza instructions

  1. Preheat oven as directed. Press pizza crust onto greased 13×9 inch baking sheet. Using a fork poke holes all over it so it doesn’t rise and bubble..
  2. Spread sauce evenly onto the crust, top with cheese and toppings. Bake as directed then toss under the broiler on low for 2-3 minutes..

Meat Lovers' Pizza Bread is brimming with seasoned saucy ground beef, spicy pepperoni and three cheeses. A hearty appetizer, our Pizza Bread is a crowd-pleasing easy recipe to make. I'm still trying to figure I'm in a major pizza mode. This will continue until we go hog wild with the pizza, perhaps eating a. The Meat Lovers' Pizza recipe out of our category Pizza!

It’s cheaper to eat junk food than Meat lovers pizza

In the beginning glance, it may appear that eating at a junk food cafe is less expensive than creating a home-cooked meal. But that’s seldom the case. A study from the University of Washington School of Community Health unmasked that folks who prepare in the home are apt to have healthier over all food diets without higher food expenses. Yet another study discovered that frequent home cooks spent about $60 each month less on food than those that ate out more often.

I don’t understand how to cook Meat lovers pizza

  • If you are intimidated by the chance of preparing a home-cooked supper, it’s essential to keep in mind that cooking is no actual science.
  • It’s usually perfectly OK to skip a component or substitute something for another Meat lovers pizza.
  • Look on line or obtain a standard cookbook for quick formula ideas.
  • As with such a thing, the more you cook, the greater you’ll become. Even when you’re a complete amateur in your kitchen, you’ll shortly grasp some rapid, healthy meals.

What formula should I personally use for Meat lovers pizza?

Basic oils like canola, plant and peanut oil have higher smoking factors, making them suitable for burning chicken. Find out about selecting the right fat for frying.

What must and mustn’t be performed when cooking Meat lovers pizza

  • Ensure every thing is frozen in a sealable pot or bag.
  • Beef in particular needs to be effectively wrapped.
  • Make bread straight from freezer, anti-waste strategy urges.
  • Remember that any such thing that’s a top water content, like lettuce, will not be the identical following being frozen and then defrosted.
  • Make an effort to freeze everything when at its freshest. Defrost beef thoroughly before cooking, but other things such as for example bread for toasting can be baked straight from the freezer.
  • Never refreeze natural beef that’s been frozen and then thawed – you can, nevertheless, freeze prepared beef that was frozen when raw.
  • Ensure the fridge is not loaded therefore complete that air can not circulate.

Strategies for getting started!

Focus on new, healthy ingredients. Baking sweet treats such as brownies, cakes, and cookies won’t help your health or your waistline. Likewise, putting an excessive amount of sugar or salt may change a healthy home-cooked supper into an bad one. To ensure your meals are good for you as well as being delicious, start with healthy substances and taste with herbs as opposed to sugar or salt.

Stock on staples. Materials such as rice, dinner, coconut oil, herbs, flour, and inventory cubes are basics you’ll likely use regularly. Keeping cans of tuna, beans, tomatoes and bags of freezing greens available can be beneficial in rustling up rapid dishes when you’re pushed for time.

Give yourself some leeway. It’s ok to burn off the rice or over-cook the veggies. After having a several tries it are certain to get simpler, quicker, and tastier!

Write a Comment


text:
September 2013 Blog Posts (145)

Why Big Companies Are Not Good Landing Spot For All H1 Candidates?

Big companies want to hire top-notch talent by reducing cost, so they go after H1 candidates. It's good deal for those companies as they utilize low cost talent and get more work done but it is not good spot for H1 candidates. Here are some reasons.

Many companies give offer letter by stating that they will sponsor candidate’s GC. Issue is that…

Added by Bakul Brahmbhatt on September 30, 2013 at 11:30pm — No Comments

Hertz seeking Corporate Recruiter in New Jersey & Florida

The new RecruitingBlogs job board has launched along with its newest job posting.

The Hertz Corporation needs to hire Corporate Recruiter in two locations:

The primary mission of the Corporate Recruiter role is to provide leadership in the assessment of recruitment needs, government compliance requirements, and staff supervision. Position Hertz as the employer of choice attracting the…

Added by Chris Russell on September 30, 2013 at 5:00pm — No Comments

Boolean Operators and More Updated!!

Boolean Operators and More Updated!!

So this is an update to my all inclusive list of operators. The update is as of 9/30/13, of course I will have other updates as I find new operators. Why you ask, well as I said below there are always new ones being discovered.…

Added by Dean Da Costa on September 30, 2013 at 3:08pm — No Comments

Hiring Expectations ...

It’s been a while since I’ve actually had some time to sit down and put some thoughts on paper. Now that I had a chance to think about it, hiring expectations seemed like a common problem recruiting professionals run into from time to time.…

Added by Paul Alfred on September 29, 2013 at 9:12am — 2 Comments

Call me a PIRATE and I'll slit your throat!

A Banker, a Doctor, and a Recruiter walk into a bar, two of them leave wanting new jobs.

Indulge me while I play a bit of make believe.  If I didn't live and breathe this business (including an occasional dream about it at night), I think I might actually enjoy reading.  Unfortunately, four score and a zillion years ago when I took the ACT's, my…

Added by Stephen Nehez, Jr. on September 27, 2013 at 2:47pm — 1 Comment

Hiring Veterans Could Be the Secret to Saving the Job Market

You’d think a sudden influx of more than 100,000 jobs in the United States would make everyone happy, right? Think again.

Between 2009 and 2012, the number of manufacturing jobs in the United States shot up from 98,000 to 230,000. With Chinese labor costs increasing by 15 to 20 percent a year, many American companies have elected to pack up their manufacturing operations…

Added by Jennifer Umali on September 27, 2013 at 10:16am — 3 Comments

The Most Important Job in the World

Today I dropped off Kennedy, my daughter, at Kindergarten just like I do every day.  When I was walking her to class, I was deep in thought.   Kennedy was holding my hand tightly and my 2 year old son, Trace, was in my arms.  I passed the cross-guard and said “hello” just like I do every morning.  I walked in the school doors and dropped her off in the cafeteria with…

Added by Will Thomson on September 26, 2013 at 4:30pm — No Comments

Cutting Hours Risky Way to Avoid Obamacare

Even with the employer mandate portion of the Affordable Care Act (ACA or Obamacare) delayed until 2015, companies are already looking for ways to get around the mandate. But they could find themselves in legal hot water if they adopt one of the most popular techniques - cutting employee hours.

Starting January 1, 2015, the employer mandate will require employers with 50 or more full-time or “full-time equivalent” employees to provide health coverage to its full-time…

Added by Debbie Fledderjohann on September 26, 2013 at 10:30am — No Comments

Advantages of Recruitment and Selection Process

Recruitment and selection process is nothing but the organization's ability to source employees to improve the quality of its human capital and stand in the competition. This process is carried by the human resource management of that particular organization, where they target to people to get the best quality employees for their organization. There are many advantages of recruitment process.

Most of the employers or recruiters around the world find themselves in many roles while…

Added by Neelam Mestry on September 26, 2013 at 8:59am — No Comments

Sell More Without Doing More Selling – Scott’s Sales Yoga Thought for the Day

A while back I was asked by Donald, a CEO I advise, for my top best practice on increasing revenues generated by his sales team. I told him what I tell all my clients: the most effective way to sell more is by doing less selling. I could tell by his expression this was not the answer he expected, and he confirmed this when he asked me to explain.

His staffing and RPO company, like many organizations, was engaging buyers in a selling experience. They used a number of the traditional…

Added by Scott Wintrip on September 26, 2013 at 8:31am — 1 Comment

A Student's Guide on how to Battle Exam Stress and come out Victorious!

Writing an exam is tedious enough on its own but the stress that's involved in the preparation just makes the whole situation so much worse! Wouldn't it be nice if you could walk in cool and calm, all your notes at your fingertips without a care in the world?

The Exam Stress

Everyone around is busy scribbling and you haven't got a clue about what…

Added by Simon Hopes on September 26, 2013 at 7:52am — 1 Comment

Beyond the Pale (Sourcing Beyond Linkedin)

As a sourcer, if you are only using one tool to find candidates, then you are severely limiting your possibilities. Don't get me wrong, Linkedin is a great sourcing tool, but it should be used in conjunction with many others. I listen to many corporate staffing managers talk…

Added by Mark Tortorici on September 25, 2013 at 10:00pm — No Comments

What do hiring managers want to see?

What you need to know when you're applying for jobs?

Rich Peterson said recruiters (Agency or Corporate)  surveyed spend 5 minutes or less reviewing candidate information and even more spend less than 2 minutes.

Given that you don't have much time to make a good impression, you really need to make sure the impression you make is a good one.

How to leap off the page in the first ten seconds someone looks at your resume.

Some "Basic" Tips. There are dozens…

Added by Richard Peterson on September 25, 2013 at 4:30pm — 1 Comment

“Non-Traditional Recruiting Media,..." convey the corporate culture and job opportunities. Media included:

a)    “Speed Interviewing like Speed Dating”

b)    Facebook, Twitter, LinkedIn, MySpace, other social networks

c)     “It’s a BLOG.” New Media Recruiting Tool

d)    LinkedIn. Huge and Underused for Recruiting

e)    Live Chats

f)     Purchasing Keywords

g)    Job Fairs

h)    JobsinPods

i)      Social Media

j)      Online Meetups

k)    Brazen…

Added by Richard Peterson on September 25, 2013 at 3:30pm — No Comments

Damn it feels grrrrrrr to be a recruiter

"PC Load Letter?? PC Load Letter??!!" - Michael Bolton, Initech

Ok, so it's not the most original pop culture reference, but the daily tech frustrations portrayed by Peter, Michael and Samir in the movie Office Space do seem to mirror those faced by today's recruiting professionals.

Every day, I see commentary around the notion that the HR and recruiting…

Added by Jed Hamilton on September 25, 2013 at 1:44pm — No Comments

Madonna’s Decades Of Success & Her Career Plan

Madonna’s Decades Of Success & Her Career Plan

Added by sheila Greco on September 25, 2013 at 1:30pm — No Comments

Mistakes Will Kill You

Redundant systems and a co-pilot who can take over if the pilot suddenly becomes ill have made commercial flight safe and efficient. Long-haul flights even carry a second crew, ensuring there are enough qualified people to do the job of flying no matter what occurs. Sports teams also have redundant people as they plan for inevitable injuries and fatigue by having a second and even third string of players ready to take the field at a moment’s notice.

These types of redundancies are…

Added by Scott Wintrip on September 25, 2013 at 11:05am — No Comments

Castrating Competitiveness

A couple of decades ago, our society began to do something that I believe has reshaped our kids and caused unintended consequences in the way they interact with others, evaluate their own self-worth, and engage themselves in business. It's when we started making sure every child received a trophy, or a medal, or a certificate at the end of a season - regardless of that…

Added by Doug Douglas on September 25, 2013 at 10:39am — 2 Comments

A Lesson in Lessons

Find the best technology so that you can teach and learn in the fastest most efficient way, but don't just start and stop with good tech. There is a human side to this equation. Even the best training management software is better when management knows how to lead their team through it. An article recently featured on Inc. gives us some great tips on how to teach anyone…

Added by Sean Pomeroy on September 25, 2013 at 8:00am — No Comments

Recruiting Metrics and Its Importance

Rich Peterson insists recruiting metrics are important.

The quantity of recruiter activity and quality of hires produced by a recruiting team are important figures to understand. Metrics can be used to judge recruiter performance, gauge the quality of employment brand, and develop effective and cost-efficient recruitment marketing.

However, when is all this data too much? When do you move from a smart strategy of examining the recruitment data generated by your team to an…

Added by Richard Peterson on September 25, 2013 at 12:00am — No Comments

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Supplementary MaterialsSupplemental Material

Supplementary MaterialsSupplemental Material. computational research indicated that DOA binds and inhibits the ATP-binding kinase domains site of mTOR as well as the assays verified the power of DOA to operate as an ATP-competitive mTOR inhibitor also to stop the SAM-dependent methylation activity of DNMTs. Our organized and approaches create the phenol-conjugated oleoside DOA being a dual mTOR/DNMT inhibitor normally taking place in EVOO that functionally suppresses CSC-like state governments responsible for preserving tumor-initiating cell properties within BC populations. Launch Cancer tumor relapse and metastatic dissemination may appear after the principal tumor continues to be eradicated by surgery, chemotherapy, rays or targeted therapy. Such life-threatening phenomena could be largely related to the incomplete elimination of so-called cancer stem cells (CSC), a particularly aggressive type of malignant cell defined in terms of functional traits of self-renewal, differentiation, therapy resistance and tumor/metastasis-initiating capacity (1C5). Accordingly, the relative abundance of CSC populations correlates with unfavorable outcomes and is an independent risk factor for tumor recurrence and post therapy progression. The CSC model has created new opportunities for cancer therapy. In the last decade, more than 150 therapeutic approaches have been envisioned to deplete the CSC pool via targeting of CSC surface antigens, CSC-associated oncoproteins, stemness regulation pathways or inhibiting CSC-related drug Ets1 resistance pathways (6,7). Unfortunately, progress in the medical development of CSC-direct approaches has been disappointing, and no anti-CSC drugs have entered the clinical use. One reason for such failure might relate to the widely accepted belief that genetically predefined populations of treatment-refractory CSC should be viewed as the sole source of minimal residual disease, tumor recurrence and metastasis. While the actual contribution of phenomena such as epithelial-to-mesenchymal transition and dedifferentiation/reprogramming plasticity to the generation of CSC during carcinogenesis remains a matter of debate (8C13), it is well accepted that conventional therapies would enrich cancer tissues with stem cell-like cancer cell populations that remain largely refractory to existing therapeutics. Accordingly, the sole credible target that could be exploited to prevent the manifestation of CSC would be the biological machinery in charge of the epigenetic proclivity of cancer cell populations to generate, maintain and perpetuate the so-called CSC-like states. Plant-derived polyphenols whose consumption has been epidemiologically, clinically and experimentally implicated in the dietary protection against aging-related chronic diseases, Norverapamil hydrochloride including cancer, are potentially useful leads to develop new families of anti-CSC drugs (14C18). For instance, curcumin, the main polyphenol in turmeric, has been shown to target functional properties of chemotherapy-resistant colon and breast CSC subpopulations (19). Norverapamil hydrochloride Sulforaphanes, a family of isothiocyanates enriched in cruciferous vegetables such as broccoli, cauliflower, kale and cabbage, can inhibit the self-renewal and tumor-initiating capacity of CSC (20). Likewise, resveratrol, a natural stilbene from a wide variety of plant species including grapes, mulberries and peanuts, can inhibit CSC traits (21). Another example is the polyphenol genistein, the predominant isoflavone in Norverapamil hydrochloride soybean-enriched foods, which has been found to reduce the tumor-initiating capacity of Norverapamil hydrochloride CSC (22). Epigallocatechin gallate, the most abundant catechin in tea, has been also found to reduce CSC-related attributes in various cancers (23). The power from the so-called Mediterranean diet plan to diminish the chance of many persistent illnesses considerably, including breast tumor (BC), continues to be largely related to the unique features of extra virgin essential olive oil (EVOO), the juice through the fruits of olive trees and shrubs obtained exclusively by mechanised means and consumed without additional refinement (24C26). And a beneficial fat composition because of its high content material (60C80%) from the monounsaturated fatty acidity, oleic acidity, another fundamental health-related quality of EVOO may be the existence of a lot of phenolic-like substances (27C29). Of.

Sepsis is a multifaceted web host response to an infection that impacts individual final results and the expense of healthcare dramatically

Sepsis is a multifaceted web host response to an infection that impacts individual final results and the expense of healthcare dramatically. in individual sepsis cases. Bendazac L-lysine If size and stress of inoculum are standardized, the super model tiffany livingston may be even more reproducible.48 The drawbacks of EPLG1 the model will be the usage of a single stress of bacterias may possibly not be representative of stomach sepsis, and a big bolus of bacterias may mimic the consequences of an individual LPS dosage because of the rapid lysis of bacterias by complement.15 Furthermore, intravenous boluses might not result in bacteria or colonization replication.10 Cecal slurry injection models. Cecal slurry shot models contain intraperitoneal shot of the standardized level of cecal items from a donor to instigate bacterial peritonitis.52 The development of mortality and disease prices could be titrated by varying the dosage of cecal slurry. Within a couple of hours of shot, adult mice screen light piloerection and reduced motion, progressing to respiratory unhappiness, labored respiration, and decreased responsiveness within 12 h.72 In comparison to an endotoxin magic size, the cecal slurry injection had a similar acute program with recovery after 72 h, although cytokine concentrations were not as high as seen with endotoxin. In contrast, the CLP Bendazac L-lysine model has a more protracted program with animals continuing to decrease beyond 72 h.68 Comparisons of leukocyte gene expression shown pronounced differences between low-mortality versions of the CLP and cecal slurry models.26 The major advantage of the cecal slurry model is the avoidance of cells stress and ischemia produced by surgical models of polymicrobial peritonitis. In addition, the cecal slurry model can be used in situations where surgery is definitely experimentally prohibited or theoretically challenging, seeing that may be the whole case in 5- to 7-d-old mice found in types of neonatal sepsis.24,26,88 One drawback of the model may be the have to make a fresh slurry before each test. This disadvantage could be prevented by storing the slurry iced in 15% glycerolCPBS, yielding a viable and even inoculum.75 Extraabdominal types of sepsis. The abdominal cavity may be the site of an infection in 60% of preclinical sepsis versions.47 However, pneumonia may be the most common way to obtain sepsis in individuals. Furthermore to pneumonia and intraabdominal attacks, urinary system and soft tissues infections will be the best 4 factors behind sepsis.56,65 According to these data, experts in the field recommend strong consideration get to the usage of multiple clinically relevant models, including people that have an extraabdominal concentrate of infection. These versions would closely imitate the clinical situation and promote an improved knowledge of the systemic pathophysiology involved with sepsis.47 Overall, the extraabdominal models have a tendency to be much less involved compared to the most intraabdominal models technically. Pneumonia versions may need short anesthesia for intranasal or intratracheal instillation of bacterias. Alternatively, aerosol inhalation may be used.16,41 are accustomed to mimic the individual clinical condition frequently. 47 In each complete case, model development depends upon the bacterial dosage and stress.82 Within a mouse style of K. pneumoniae, mice shown decreased respiratory price, labored respiration, and reduced activity within 6 to 24 h of inoculation.28 Urosepsis models generally involve injecting bacteria in to the bladder to make an ascending urinary system infection.12,37 Soft-tissue infection models may be made by simple subcutaneous injection of bacterias such as for example S. pyogenes. Mice might display systemic signals and high mortality prices within two or three 3 d, consistent with various other sepsis models.13 With regards to the study goals, extraabdominal models may be used to study local pathology as compared with sepsis; therefore, the welfare issues may vary with these models.48 Current recommendations. The pain category for nonsurgical models of sepsis is not always be obvious, and Bendazac L-lysine few data exist on the use of analgesics in nonsurgical models. Considerations for analgesia in medical animal models and human being intensive care individuals often focus on the invasive methods or comorbidities experienced rather than the septic state. For nonsurgical models, the initial lack of an invasive procedure to make Bendazac L-lysine sepsis might decrease the perceived dependence on analgesia. Within a scholarly research looking at the CLP model using the cecal slurry.

A knowledge, attitude and practice (KAP) research was conducted in three districts of Malawi to check whether the schooling had led to elevated knowledge and adoption of recommended pre- and post-harvest crop administration procedures, and their contribution to lowering aflatoxin contaminants in groundnut, sorghum and maize

A knowledge, attitude and practice (KAP) research was conducted in three districts of Malawi to check whether the schooling had led to elevated knowledge and adoption of recommended pre- and post-harvest crop administration procedures, and their contribution to lowering aflatoxin contaminants in groundnut, sorghum and maize. not eating grade-outs due to economic motivation incompatibility, leaving prospect of improving the procedures further. This existing difference within the adoption of aflatoxin mitigation procedures calls for AC-55541 strategies that consider farmers desires and incentives to achieve sustainable behavioral transformation. L), common bean (L) and pigeonpea (L) amongst others [1]. In Malawi, groundnut is certainly a significant crop harvested on 390,000 ha [2], by smallholder farmers mostly. Groundnut production presents a whole lot of advantages to the farmers with regards to improving earth fertility by repairing atmospheric nitrogen and offering a significant income source and food. Groundnut is certainly consumed as roasted or boiled kernels locally, prepared into peanut butter, pressed for essential oil, or surface into natural powder that’s put into meals or porridge. Groundnut is also a major ingredient in Ready-to-Use Restorative Food (RUTF) that AC-55541 is fed to malnourished children [3]. The consumption of groundnut, especially when it is not sorted to remove moldy, shriveled, insect-damaged and broken kernels, increases the risk of aflatoxin exposure for consumers [4]. Maize (L) is the main staple food in Malawi, as well as in many additional sub-Saharan African countries, and is also as susceptible to mold illness and aflatoxin contamination AC-55541 as groundnut. Both maize and groundnut are regularly consumed by households, posing the risk of exposure to aflatoxins. Sorghum ((L) Moench) is definitely another major staple food crop cultivated in the Lower Shire valley of Malawi, an area prone to drought and high temperature, which predisposes grain infection by aflatoxin-producing fungi species specifically. Aflatoxin contaminants may appear both in the field (pre-harvest and preliminary post-harvest) and under storage space services (post-harvest). Pre-harvest contaminants, however, is normally more essential when vegetation knowledge end-of-season drought [5,6]. Furthermore, starchy and oil crops, the gathered elements of which develop underground, such as for example groundnut and Bambara nut ((L.) Verdc), have a tendency to end up being at higher aflatoxin contaminants risk in comparison to vegetation with harvestable parts above surface [7]. Pre-harvest contaminants in maize or sorghum takes place when the fungi infects the kernels via airborne conidia that colonize the silk during flowering or once the kernels are broken from insect nourishing. All starchy vegetation are vunerable to contaminants after harvest, if they’re dried on bare soil [7] specifically. A study looking into the prevalence of aflatoxin contaminants both in groundnut and maize in Malawi reported an occurrence of 8% to 21% [8], above the suggested the meals and Medication Administration (FDA) degrees of 20 parts per billion (ppb) of aflatoxin [9]. Following studies have got reported elevated aflatoxin contaminants in grain and foods that exist in marketplaces and households [4,8,10,11]. When consumed, aflatoxin-contaminated food leads to undesirable health insurance and nutrition consequences [12]. Long-term contact with sub-clinical aflatoxin amounts leads to persistent health outcomes such as for example cancer and it has been associated with childhood stunting, whereas severe publicity results in loss of life or aflatoxicosis, a rarer final result [12]. Contaminated grain may also adversely influence trade as well as the broader overall economy. Malawi for example has lost a significant export market share, especially to lucrative markets in Europe, since 1990, primarily due to aflatoxin contamination of its groundnut grain [8,11]. Farmers can mitigate aflatoxin contamination in plants before harvest and at harvest by adopting appropriate agronomic methods such as timely planting, providing supplemental irrigation, water harvesting, applying manure and also through the application of atoxigenic strains of [11,13]. Rabbit Polyclonal to Cyclin H Post-harvest mitigation of contamination is definitely achieved through appropriate drying of create after harvest, sorting to remove damaged and shriveled kernels, and storage in well aerated facilities, or in hermetic storage bags [14]. Farmers understanding, attitude and practice (KAP) of mitigating aflatoxin contaminants may donate to lowering aflatoxin contamination and improving nutritional, health, and economic impacts. Due to the severity of the aflatoxin contamination challenge in Malawi, several training programs have been undertaken by diverse organizations, albeit with limited success. There are few studies conducted so far in Malawi to understand farmers KAP on mold or aflatoxin contamination, [15] especially their attitude toward practicing taught mitigation approaches and its gaps in implementation. Considering the need for designing effective behavioral change tools to enhance the implementation of mitigation efforts, this study aims to: (a) determine the level of KAP.

Supplementary MaterialsSupplemental data jci-130-129126-s310

Supplementary MaterialsSupplemental data jci-130-129126-s310. for leukemia patients with rearrangements or mutations. or translocations are particularly prevalent in infant leukemias, constituting up to 80% of infant acute lymphoblastic leukemia (ALL) cases, which demonstrate a high level of resistance to chemotherapy (9, 10). translocations lead to fusion of the N-terminal fragment of with 1 of over 60 protein partners (11C13), resulting in the expression of MLL fusion proteins that enhance proliferation and block hematopoietic differentiation, ultimately driving the development of leukemia (14). Because of poor patient outcomes, MLL leukemia represents an unmet medical need, necessitating the development of new therapies. The protein-protein interaction between menin and MLL fusion proteins plays a critical role in the pathogenesis of MLL leukemia, and the genetic disruption of this interaction abrogates the development of acute leukemia in vivo (15C17). Our previous work has resulted in the development of first-in-class small-molecule inhibitors of the menin-MLL1 interaction, which directly bind to the MLL1 binding site on menin and block this protein-protein interaction (17C23). Because the menin binding motif is retained in all MLL fusion proteins, these compounds also block the interaction of menin with MLL fusions (22). The menin-MLL1 inhibitors that we developed previously, including MI-503 (17) and MI-1481 (21), demonstrate relatively robust activity and an on-target mechanism of action in the Rabbit Polyclonal to Cyclin D3 (phospho-Thr283) MLL-rearranged leukemic cells and delay leukemia progression in mouse models of MLL leukemia. However, the existing small-molecule inhibitors of NSC-41589 the menin-MLL1 interaction require further optimization of their potency, selectivity, pharmacokinetic (PK) profile, and other drug-like properties before they can be translated to clinical studies in leukemia patients. Recent studies have also revealed the importance of the menin-MLL1 wild-type interaction in acute myeloid leukemia (AML) with mutations in the nucleophosmin 1 (mutations are found in over 30% of AML patients (25, 26) and are associated with the upregulated expression of genes (24, 27, 28). Mutations in co-occur with mutations in other AML driver oncogenes, such as (in ~60% of cases, including FLT3Cinternal tandem duplication [(in ~50% of cases) (29C31). Coexistence of the mutations defines the most NSC-41589 unfavorable category of mutations upon treatment with the previous generation of menin-MLL1 inhibitors (MI-503 and MI-2-2) (24). However, high concentrations of these compounds (>2 M) were required to affect gene appearance in the rearrangements or mutations. We demonstrate that MI-3454 as an individual agent induces full remission or regression in the being a pharmacodynamic biomarker of treatment response towards the menin-MLL1 inhibitor in leukemia. General, this work offers a solid rationale for scientific translation from the menin-MLL1 inhibitor to severe leukemia sufferers with translocations or mutations. Outcomes Advancement of a potent menin-MLL1 inhibitor with subnanomolar inhibitory activity highly. We’ve previously provided proof idea that inhibition from the menin-MLL1 relationship with the small-molecule inhibitor MI-503 NSC-41589 (Supplemental Body 1; supplemental materials available on the web with this informative article; https://doi.org/10.1172/JCI129126DS1) delays the development of leukemia in vivo (17). Right here, we utilized the crystal framework of menin in complicated with NSC-41589 MI-503 (4X5Y in PDB) to create brand-new analogs with improved inhibitory activity and optimized drug-like properties. These initiatives resulted in the introduction of MI-3454 (Body 1A), that was attained by substituting the thienopyrimidine band using the = 3. mP, millipolarization. (C) Crystal framework from the meninCMI-3454 complicated (1.24 ?). Menin is certainly shown in surface area representation (carbon atoms NSC-41589 in grey, oxygen in reddish colored, nitrogen in dark blue, sulfur in yellowish) and MI-3454 is certainly shown in stay representation (carbon atoms in green; color coding for air, nitrogen, and sulfur atoms is equivalent to for menin residues; fluorine atoms are in light blue). (D) Information on connections of MI-3454 with menin. Color coding such as C. (E) Pharmacokinetic research in mice performed for MI-3454 (mean SD, = 3) demonstrating bloodstream focus of MI-3454 after dental (p.o.) dosage of 100 mg/kg and intravenous (we.v.) administration at 15 mg/kg. (F) Titration curves from MTT cell viability assay performed after seven days of treatment of individual MLL leukemic cell lines (MLL-tr) with MI-3454: MV-4-11 (MLL-AF4), MOLM-13 (MLL-AF9), KOPN-8 (MLL-ENL), SEM (MLL-AF4), RS4-11 (MLL-AF4), and control leukemic cell lines (nonCMLL-tr): K562, Place2, REH, and U937; mean SD, = 4. Two to 3 indie MTT experiments had been performed for every cell line. Consultant graphs are proven. GI50 values match MI-3454 concentrations necessary for 50% inhibition of cell proliferation. (G) Quantitative RT-PCR performed in MV-4-11 cells (still left) or MOLM13 cells (best) after 6 times of treatment with 50 nM MI-3454. Gene appearance was normalized to HPRT1 and referenced towards the DMSO-treated cells. Data stand for 2 independent tests, each performed in duplicate (suggest SD,.

Supplementary MaterialsSupplementary Information 41598_2020_65250_MOESM1_ESM

Supplementary MaterialsSupplementary Information 41598_2020_65250_MOESM1_ESM. clones from the ERK1 and ERK2 isoforms were generated in SUM149 and BT549 TNBC cells using shRNA lentiviral vectors. ERK2 knockdown significantly inhibited anchorage-independent colony formation and mammosphere formation, indicating compromised self-renewal capacity. This effect correlated with a reduction ML-385 in migration and invasion. SCID-beige mice injected via the tail vein with ERK clones were employed to determine metastatic potential. SUM149 shERK2 cells had a significantly lower lung metastatic burden than control mice or mice injected with SUM149 shERK1 cells. The Affymetrix HGU133plus2 microarray platform was employed to identify gene expression changes in ERK isoform knockdown clones. Comparison of gene expression levels between SUM149 cells with ERK2 or ERK1 knockdown revealed differential and in some cases opposite effects on mRNA expression levels. Those changes associated with ERK2 knockdown predominantly altered regulation of CSCs and metastasis. Our findings indicate that ERK2 promotes metastasis and the CSC phenotype in TNBC. isoform specificity9. We previously showed that TNBC patients with ERK2-overexpressing tumors had a poorer prognosis than TNBC patients with low-ERK2 expressing tumors10, suggesting that modulation of ERK2 could be a therapeutic strategy. Previous reports have shown that ERK2, but not ERK1, plays an essential role in the epithelial-mesenchymal transition (EMT), which is required for the acquisition of stem cell-like properties11,12. The transitional mesenchymal phenotype is a process required for ML-385 metastasis involving loss of cell polarity, repression of epithelial genes, and an increase ML-385 in motility and invasiveness13,14. Within a pathologic framework, these obtained features enable tumor development and metastasis. EMT is usually directly associated with the CSC phenotype in breast malignancy, evidenced by an increased ability to form mammospheres12. TNBC is usually characterized by EMT and is highly associated with stem cell markers, which have been linked to biological aggressiveness15. Here we provide evidence supporting the notion that ERK1 and ERK2 have functionally distinct properties and that ERK2, not ERK1, primarily contributes to lung metastasis in a TNBC mouse model. Gene expression microarray analysis of ERK1 knockdown vs. ERK2 knockdown revealed that genes with expression changes associated with ERK2 knockdown predominantly altered regulation of CSC and metastasis. Amongst these genes, EGR1 is an ideal candidate for further investigation, as its downstream targets affect cell development, migration, and metastasis16C19. The knockdown of ERK2 led to lower EGR1 on the mRNA level considerably, validating our microarray data. Our results suggest that ERK2 works with the CSC phenotype and metastasis in TNBC and reveal potential applicants (Desk?1) for analysis in additional mechanistic studies. Desk 1 Microarray id of gene appearance changes in Amount149 cells with ERK2 knockdown. marker of tumorigenicity was decreased by 74% and 60% using a lack of ERK2, however, not ERK1, in both Amount149 and BT549 TNBC cells respectively (Fig.?2D). ERK2 is certainly a potent drivers of self-renewal capability in TNBC Research show that EMT network marketing leads to the era of breasts cancers cells with stem cell-like properties with the capacity of self-renewal12. These cells could be enriched by developing them as mammospheres, that Mouse monoclonal to Cytokeratin 19 are 3-dimensional spherical breasts cancers cell colonies that develop in suspension system in serum-free, growth-factor-enriched mass media and so are seen as a the appearance of particular cell surface area markers, such as for example CD44+/Compact disc24?/low. To look for the influence of ERK2 and ERK1 in the self-renewal capability of TNBC cells, we examined the consequences of ERK1 or ERK2 knockdown on mammosphere development and appearance of Compact disc44 and Compact disc24 in the cell surface area. The knockdown of ERK2 considerably reduced the forming of mammospheres in both Amount149 (by 30%, p?=?0.01) and BT549 (by in least 48%, p?=?0.0001) TNBC cell lines (Fig.?3A). Mammosphere development is unaffected with the knockdown of ERK1 in BT549 cells, and only 1 ERK1 knockdown clone (shERK1 51-4) in Amount149 cells provides reduced mammosphere development (by 40%, p?=?0.01) (Fig.?3A). Lack of ERK2 decreased the small percentage of Amount149 cells with Compact disc44+/Compact disc24 also?/low surface area marker expression design (Additional document 2: Supplementary Fig.?2); set alongside the small percentage of control cells, proportions of shERK2 40-7 and.

Purpose To analyze the effects in microaneurysm (MA) and perifoveal perfusion in nonproliferative diabetic retinopathy (NPDR) sufferers with macular edema (ME) after early intensive treatment using intravitreal ranibizumab (IVR) shots

Purpose To analyze the effects in microaneurysm (MA) and perifoveal perfusion in nonproliferative diabetic retinopathy (NPDR) sufferers with macular edema (ME) after early intensive treatment using intravitreal ranibizumab (IVR) shots. MA Perifoveal and Turnover Non-Perfused Region The full total mean amount of MAs before IVR shot was 5.683.41, which reduced to at least one 1 significantly.601.73 after administration of six monthly IVR shots ( 0.05 with baseline. Abbreviation: MA, microaneurysm. Open up in another window Body 7 Mean turnover, price of development, and price of disappearance of microaneurysms within the six-month research period. significance is 0 *Statistically.05 with baseline. The mean perifoveal non-perfused area measured across three FA assessments was 2.5170.456 mm2 at baseline, which after administration of three, monthly IVR injections, decreased to 2.1560.387 mm2 and after six, monthly IVR injections, increased to 2.4950.293 mm2. Compared to baseline, after administration of six, monthly IVR injections, perifoveal non-perfused area showed a moderate decrease, though the difference was not statistically significant ( 0.05 with *Repeated measures analysis of variance. Abbreviations: IVR, intravitreal ranibizumab; BCVA, best-corrected visual acuity; CRT, central retinal thickness; MA, microaneurysm; ETDRS, GSK 1210151A (I-BET151) Early Treatment Diabetic Retinopathy Study. Open in a separate window Physique 8 Changes in extent of mean perifoveal non-perfused area over the six-month study period. Safety Outcomes No ocular or systemic adverse events associated with IVR injections were observed in any participant during the study period. Discussion In this study, we prospectively analyzed the outcomes following administration of monthly IVR injections for 6 months in NPDR patients with DME. The patients showed visual improvement by 8.76 letters, after completing the study-treatment protocol, as compared to baseline as well as exhibited a 105.8-m reduction in CRT. These results were much like those of other studies that analyzed the use of anti-VEGF drugs for DR.14C17 Further, we found that 80% patients showed improvements in CRT after administration of month to month IVR injections for 6 months. An interesting obtaining was that among these patients, 70% showed improvement in CRT with administration of 3 IVR injections GSK 1210151A (I-BET151) and 30% exhibited improvements in CRT after administration of 6 IVR injections. In other words, we imply that during the treatment of NPDR patients with DME, administration of all 6 injections may not be necessary and in some cases, 3 injections could prove to be quite effective. MAs develop in the early stages of DR, and the total number as well as turnover rate are known to play an important role in identifying and defining the disease cycle. Furthermore, MAs can be a predictive factor for the occurrence of complications that may cause visual impairment by worsening retinopathy or ME.18,21,26 Formation and disappearance of MAs is a dynamic activity, of which MA disappearance occurs mostly due to platelet and fibrin thrombi, is an irreversible process, and can indicate the occurrence of retinal capillary occlusion and vascular damage. However, it might bring about the restructuring of retinal capillary-flow and vasculature bypass.27,28 Therefore, not merely the forming of MAs but also their disappearance is highly recommended important through the evaluation of MA turnover. MA MA and matters turnover are great markers for DR development, and high MA turnover is certainly a risk aspect for the introduction of medically significant macular edema (CSME) needing photocoagulation. Further, MA turnover provides been proven to become more dependable than MA matters.18,20 Leicht et al,29 reported that high MA turnover can lead SEMA4D to a higher threat of developing CSME and worsening DR without DME. In GSK 1210151A (I-BET151) addition they recommended that anti-VEGF therapy using IVR could hold off the development to diabetic fundus and change existing fundus adjustments to revive normality. Limited analysis exists regarding the consequences of VEGF inhibitors such as for example ranibizumab on MA turnover in NPDR sufferers with DME, no potential research has examined the efficiency of intense treatment using ranibizumab, which includes been performed inside our research. This is actually the power of our research. In this scholarly study, we noticed that the full total amount prospectively, formation price, disappearance price, and general turnover of MAs, each decreased after administration of 6 regular IVR shots significantly. Our outcomes showed these MA-related variables could be utilized as suitable markers for analyzing the development of retinopathy which IVR shots could hold off the development GSK 1210151A (I-BET151) of DR. Hyperglycemia in diabetes induces high blood sugar concentration inside the retina, harming the endothelium and pericytes from the retinal vessels eventually. These structural damages result in retinal destruction and ischemia from the blood-retinal.

This first International Alliance for Biological Standardization Covid-19 webinar brought a wide selection of international stakeholders together, including academia, regulators, industry and funders, with a significant delegation from low- and middle-income countries, to go over the virology, immunology and epidemiology of, as well as the vaccine development for SARS-CoV-2

This first International Alliance for Biological Standardization Covid-19 webinar brought a wide selection of international stakeholders together, including academia, regulators, industry and funders, with a significant delegation from low- and middle-income countries, to go over the virology, immunology and epidemiology of, as well as the vaccine development for SARS-CoV-2. Despite rumours, there is absolutely no technological evidence that it’s a laboratory-produced trojan. The main risk factor is normally contact of human beings with live wildlife at marketplaces, which isn’t unusual in East Asia. At an extremely early stage, in comparison to prior pandemics, electron microscopy pictures and the entire genome series had been available, providing goals for vaccine advancement. The GISAID Effort [https://www.gisaid.org], which promotes the fast posting of data from SARS-CoV-2 (as well while data from influenza viruses) has collected more than 34,000 SARS-CoV-2 genomes, from labs around the world. Data display the disease has a degree of similarity to viruses from bats and pangolins. Based on genetic diversity, three genogroups are defined, BRD9539 groups G, V and S, of which the G group is currently most prominent and has been additionally subdivided in 3 sub-groups (G, GR and GH). However, the genetic diversity seems to have limited impact on antigenicity. Based on French data [1], the imply age of hospitalized individuals was 68 years of age, while the imply age at time of death was 79 years of age. Half of the hospitalizations and more than 80% of deaths occurred in individuals more than 70 years. Furthermore, 56.2% of hospitalizations and 60.3% of deaths were male (Fig. 1 ) [1]. Open in a separate windowpane Fig. 1 Sex variations in hospitalization, ICU admissions and death due to Covid-19 Resource: Salje et al. Technology, 2020. The availability of the sequence data has also enabled development of diagnostic tools. Diagnosis is usually based on nasopharyngeal swabs (a sample from the upper respiratory tract). Using real-time (RT-)PCR, a high accuracy can be obtained (combining high sensitivity with high specificity) but variation exists between different tests [2]. This molecular assay can be used to identify infected patients but also to monitor individuals to monitor/prevent spread of the infection. While the virus can also be found in stool using molecular assays, the value of this finding is as yet unclear, but detection does not seem to be related to disease severity. Using a semi-quantitative RT-PCR on different samples (nasopharyngeal swab, blood, urine, and stool samples), three different clinical and biological types of evolution in five patients infected with SARS-CoV-2 could be BRD9539 observed [3]: BRD9539 (1) paucisymptomatic individuals, with high nasopharyngeal titres within the first 24?h of the illness onset but early recovery; (2) a two-step disease progression, with a secondary worsening around 10 days after disease onset with a decreasing viral load in nasopharyngeal samples and a shift to detection of virus in the lower respiratory tract; and (3) a rapid evolution towards multiple organ failure and a persistent high viral load in lower and upper respiratory tract with systemic virus dissemination and virus detection in plasma [3]. Antibody detection methods have been developed to investigate seroepidemiology, including ELISAs, lateral flow assays and virus neutralization assays, although the latter need to be performed in biosafety level 3 facilities. These assays provide insight into the number of previously infected individuals. However, different and various antigens in a assay provides different photos assays, therefore, it is vital to learn which check was utilized, to have the ability to interpret the info. Concerning the immunological response to disease, in three individuals, viral loads had been low without apparent quantitative difference linked to intensity [4]. Interleukin(IL)-6, C-reactive proteins and interferon(IFN) -induced proteins 10 had been elevated in both symptomatic individuals. Strikingly, no IFN-2 was detectable Rabbit Polyclonal to Histone H2A (phospho-Thr121) in both of these patients. On the other hand, IL-6, C-reactive proteins and IFN -induced proteins 10 continued to be low through the medical center isolation stay for the asymptomatic specific and a substantial elevation of plasmatic IFN-2 was noticed [4]. Monitoring immunological markers from disease onset, it had been shown how the baseline lymphocyte count number was higher in survivors than in non-survivors [5] significantly. In survivors, lymphocyte count number was most affordable on day time 7 after disease starting point and improved during hospitalization, whereas serious lymphopenia was seen in non-survivors. Degrees of IL-6 had been clearly raised in non-survivors weighed against survivors through the entire clinical program and improved with disease deterioration. Towards a diagnostic technique, the data appear to display all contaminated individuals will establish an immune system response (seroconversion), although.

Introduction: Migraine is a severe sort of headache with the chance hereditary of 50%

Introduction: Migraine is a severe sort of headache with the chance hereditary of 50%. Conclusion: The obtaining indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control Protopanaxatriol of migraine. strong class=”kwd-title” Keywords: Migraine disorders, Protein conversation maps, Genes Highlights Gene activation is the dominant actor in the interactome of migraine. Insulin has been found as the most significant related gene in migraine. Migraine could be a metabolism-dependent disorder. Simple Language Summary Migraine pain disturbs the patients lifestyle. There’s a comprehensive large amount of information regarding Protopanaxatriol migraine, however, its administration requirements much analysis. In this scholarly study, the molecular areas of migraine are examined to discover its controllable natural factors. Targeting these elements may be useful in migraine treatment. The results of the scholarly research demonstrated that fat Sele burning capacity control, insulin regulation especially, plays a crucial function in migraine. 1.?Launch Migraine is a complex episodic headache and is known as the sixth cause of reducing the quality of life condition according to Protopanaxatriol the Who also statement. Also, its incidence is usually higher in women (Goadsby et al., 2017). This type of headache is usually associated with some other problems, like nausea, vomiting, awareness to light, and audio that may lead to aura (Pellacani et al., 2016). High-frequency headaches, medication overuse, weight problems and many risk factors are essential in migraine development (Moriarty & Mallick-Searle, 2016). Understanding the systems of the condition is under analysis still. The medical diagnosis of migraine is mainly based on scientific assessments (Shin, Shin, & Kim, 2017). Pathophysiological research of migraine claim that it really is connected with vascular program irritation (Mastia et al., 2016). Molecular research have discovered some molecular agencies in this respect such as for example different neuropeptides and cytokines such as for example C-Reactive Proteins (CRP), Interleukin-1 Protopanaxatriol (IL-1), IL-6, and Tumor Necrosis Aspect- (TNF-) (Mastia et al., 2016). Great throughput studies could possibly be beneficial to present a lot of potential biomarkers in various kinds of illnesses. There are a few genomic, proteomic, and metabolomic analyses linked to deciphering the chance of migraine. These strategies present potential biomarkers for migraine that may be useful for medical diagnosis and remedies (Gerring, Powell, Montgomery, & Nyholt, 2018; Mastithe et al., 2016; Shin et al., 2017; Tafuri et al., 2015). Bioinformatics can provide more in this respect also. By examining genes in a complete interacting design, the function of each you can end up being better characterized. Actually, any changes in the phenotype is related to alteration in connection of these molecules and in this way, a specific biological answer could be found. This biological response could cause abnormal behavior, which can be considered as a disease state (Tavirani et al., 2018). In light of this trend and via network analysis, many genes related to a specific disorder could be screened and analyzed to recognize crucial genes which can be nominated as diagnostic providers or drug focuses on (Rezaei-Tavirani, Tavirani, & Rostami, 2018). With this study, genes related to migraine are interacted, analyzed, and screened to find vital ones to address possible restorative biomarkers for this mind disorder. 2.?Methods 2.1. Protein-protein connection network analysis The connected genes to migraine were acquired via disease query of STRING database and were interacted as Protein-Protein Connection (PPI) network by Cytoscape version 3.6.0. The genes were connected by default condition via undirected edges. The primary connected the different parts of the PPI network were visualized and analyzed with the network analyzer plugin of Cytoscape. The network was by level values design. The high-value level nodes (levels above Mean+SD) had been named hub-nodes. The nodes seen as Protopanaxatriol a the quality value of betweenness centrality (the very best 5% of nodes) had been highlighted as bottlenecks. The normal nodes between hubs and bottlenecks had been presented as hub-bottlenecks. The central nodes, including hubs, bottlenecks, and hub-bottlenecks, had been organized being a sub-network and analyzed to determine node properties. 2.2. Actions network evaluation The actions maps from the 33 central nodes had been examined via CluePedia v1.5.0. The appearance, activation, and inhibition romantic relationships between your nodes had been investigated to get the significant function of the node in managing the various other central nodes. The cable connections had been regarded as directional sides. 3.?Results A complete of 600 genes connected with migraine were requested from disease query of.

Data Availability StatementThe raw data supporting the conclusions of the content will be made available from the writers, without undue booking, to any qualified researcher

Data Availability StatementThe raw data supporting the conclusions of the content will be made available from the writers, without undue booking, to any qualified researcher. the translation from the mobile reactions towards the implant situation. Notably, there is absolutely no current powerful model which includes astrocytes, microglia, neurons and oligodendrocytes, the four rule cell types, essential towards the ongoing wellness, function and wound reactions from the central anxious program (CNS). In earlier study a co-culture of major mouse mature combined glial cells and immature neural precursor cells had been shown to imitate several essential properties from the CNS response to implanted electrode components. Nevertheless, the method had not been robust and used to 63 times, influencing reproducibility and widespread make use of for evaluating brain-material interactions significantly. In today’s research a fresh co-culture approach continues to be developed and examined using immunocytochemistry and quantitative polymerase string response (qPCR). The ensuing method reduced enough time in tradition considerably and the tradition model was c-Kit-IN-2 proven to possess a genetic personal similar compared to that of healthful adult mouse mind. This new powerful CNS tradition model gets the potential to considerably improve the capability to convert data towards the reactions. Goat polyclonal to IgG (H+L)(HRPO) prediction, CNS, cell tradition, neural user interface response Introduction Looking into the biocompatibility of mind interfacing products using animal versions is expensive, frustrating (Gilmour et al., 2016) and data produce from each pet can be tied to the tissue control and histological strategies used within a report (Woolley et al., 2011). Nevertheless, existing versions for looking into central anxious system (CNS)-gadget c-Kit-IN-2 interactions aren’t a viable substitute, as they badly represent the complicated cell interactions inside the CNS and offer little information for the anticipated response (Horvath et al., 2016; Belle et al., 2018). Not surprisingly, cell tradition is a robust way of high-throughput studies, allowing parallel evaluation across a lot of factors (Astashkina et al., 2012; Zang et al., 2012). A perfect solution can be a cell tradition model with plenty of complexity to allow useful understanding into implant efficiency, without compromising on capability to trial multiple factors. For neural cell tradition versions to become mimetic from the CNS in disease and wellness, mimicking cellCcell relationships is essential. Relationships both within and between specific glial and neural cell types are crucial for the development, function and dysfunction of the CNS c-Kit-IN-2 (J?kel and Dimou, 2017). The astrocyteCmicroglia interaction is the most notable cellCcell interaction and it is pivotal in development, normal function, and response to damage (Liddelow et al., 2017; Yates, 2017). Astrocytes and microglia perform multiple roles in CNS development, ongoing health, and degenerative disease (Burda and Sofroniew, 2014; Pekny and Pekna, 2014; Ferreira and Bernardino, 2015; Sofroniew, 2015; Ziebell et al., 2015; Burda et al., 2016; Liddelow and Barres, 2017). Importantly, the functions of these cells evolve during development undergoing dynamic genotypic and phenotypic changes which are integral to the development of the CNS (see Reemst et al., 2016; Hasel et al., 2017 for in depth reviews). Glial cells change roles from promoting development of neural networks and myelination, to maintaining the complex function of the adult CNS. In response to injury in the mature CNS, glial cells within the wound parenchyma transition to a reactive state (Silver and Miller, 2004; Anderson et al., 2014; Gilmour et al., 2016). In this reactive state mature glial cells produce an environment which does not support redevelopment of neural networks, inhibiting neuronal cell migration and axonal growth (Smith et al., 1990; Canning et al., 1996; Fawcett and Asher, 1999; Faulkner, 2004; Sofroniew, 2009; Cregg et al., 2014; Burda et al., 2016). In contrast, immature glial cells from fetal or neonatal origins lack the ability to undergo reactive gliosis-like reactions and (Schwartz et al., 1989; Wu and Schwartz, 1998). A number of mixed glial and neuronal cultures have already been developed so that they can incorporate complicated cell behaviors into versions (Potter and DeMarse, 2001; Polikov et al., 2006; Thomson et al., 2008; Nash et al., 2011b; Boomkamp et al., 2012; Sommakia et al., 2014). It really is anticipated that this difficulty introduces improved positioning using the CNS cell response. Nevertheless, these tradition versions possess complex, multistep methodologies (Polikov et al., 2009), are really sensitive to small modifications and need additional stimulating elements to induce reactive gliosis, restricting their value like a high-throughput evaluation device (Gilmour et al., 2016). Current versions have another restriction whereby the obvious upregulation of glial fibrillary acidic proteins (GFAP) and Iba1 in astrocytes and microglia respectively in response to insult will not effect on neural health insurance and regrowth (Polikov et al., 2006; Sommakia et al., 2014). The maturity of glial cells and their c-Kit-IN-2 comparative ability to go through reactive gliosis offers implications for the advancement and usage of c-Kit-IN-2 complicated tradition versions for modeling CNS and ramifications of injury. In brain injury and device interactions, scar tissue is usually formed with glial cells being the dominant component. These cells modulate neuron and oligodendrocyte function, survival, or.

The basal forebrain (BF) plays crucial roles in arousal attention and

The basal forebrain (BF) plays crucial roles in arousal attention and memory and its impairment is connected with a number of cognitive deficits. house cages (innate) or performed a move/no-go auditory discrimination job (discovered). Cholinergic neurons had been consistently UK-383367 thrilled during motion including working and licking but GABAergic UK-383367 and glutamatergic neurons exhibited different replies. All cell types had been turned on by overt abuse either inside or beyond the discrimination job. These findings reveal functional distinctions and similarities between BF cell types during both spontaneous and task-related behaviors. UK-383367 was thought as the lack of any observable motion involved movements such as for example rearing and postural changes without locomotion. Movement between different places inside the cage was have scored as included rhythmic actions such as for example scratching or repeated stroking of the facial skin using the forepaws. Analysis or intake of meals (regular UK-383367 chow supplemented with Hartz brand hamster meals including seed products and pellets) was have scored as = × may be the uncorrected fluorescence in a ROI may be the fluorescence within a 20 μm band encircling the ROI (presumed to result from the neuropil) and it is a correction aspect computed as the proportion of the fluorescence within a bloodstream vessel and its own encircling neuropil with the backdrop Rabbit Polyclonal to OR4L1. worth of pixel intensities beyond your zoom lens subtracted (Pinto and Dan 2015 In cases where no blood vessels were present in the imaging field a constant value of 0.6 was utilized for as calculated above (Pinto and Dan 2015 Slow bleaching of the calcium signal was corrected for by low-pass filtering using a 300 s sliding screen (Pinto and Dan 2015 Evaluation Analyses were performed on Z-scored ΔF/F using the program mean fluorescence portion as the denominator. For our evaluation of neuronal activity during UK-383367 licking we initial defined licking rounds as comprising licks separated by an period of <2 s. Adjustments in neuronal activity on the starting point of licking rounds had been computed as the mean activity during 0.5 s following first lick within a bout minus set up a baseline of just one 1.0-0.5 s preceding the first lick since activity often started to boost prior to licking onset. Individual behavioral classes were truncated in the last trial in which mice licked. Changes in activity at the time of trial incentive or consequence (end result) were determined as the mean of a 1 s period after end result minus the mean of a 0.2 s pre-outcome baseline period. The shorter pre-outcome period was chosen to avoid contamination by stimulus-related activity. Changes related to additional task events were determined as the mean of 1 1 s post-event minus the mean of a pre-event baseline of 0.5 s. To determine latencies of reactions to air flow puffs UK-383367 we arranged a threshold of 2 × the standard deviation of a baseline period of 2 s preceding the event and then recognized the first time point at which ΔF/F exceeded that threshold for at least 5 consecutive frames (0.25 s). Cells without supra-threshold reactions were excluded (5 of 56 ChAT 46 of 288 GAD and 26 of 156 VGLUT neurons). For calculating latencies of reactions to licking and auditory stimuli the threshold was collection as 3 × the standard deviation of a baseline period. The baseline was arranged from 2 to 1 1 s preceding licking to include responses with bad latencies. For auditory stimuli the baseline period prolonged from 2 to 0.5 s preceding the auditory stimulus to exclude responses to the start cue. We regarded as only the first licks within a bout that were more than 2 s before or after auditory stimuli. All analyses were performed in MATLAB. Statistical checks Results are reported as imply ± SEM unless specified otherwise. We applied the Lilliefors test to determine normality of data units and then used either test for multiple comparisons. Multi-factorial experiments were analyzed using 2-way ANOVA with Tukey's test. Histology After experiments concluded mice were deeply anesthetized with isoflurane and transcardially perfused 1st with 10 mL space temperature saline and then 10 mL chilled 4% PFA. Acetone was used to dissolve the dental care acrylic round the microscope baseplate microendoscope and headplate. The brain was then dissected from your skull immersed in 4% PFA for 12 h then transferred to a solution of 30% sucrose in PBS for 24 h. Brains were then freezing in OCT (Ted Pella) and stored at ?80°C prior to cryosectioning on a Microm HM525 cryostat. Implanted lens positions.


text:
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Xiaomi Mi 11 Lite 5G Performance Report: First Taste of the Snapdragon 780G

Announced a few weeks ago, we’re looking at the impressive performance and efficiency of the new Qualcomm Snapdragon 780G SoC, courtesy of Xiaomi’s new Mi 11 Lite 5G mid-range phone.

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Intel 3rd Gen Xeon Scalable (Ice Lake SP) Review: Generationally Big, Competitively Small

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Xiaomi Announces Mi 11 Ultra: The Largest Smartphone Camera

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Qualcomm Announces Snapdragon 780G: New 5nm 765 Successor

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Qualcomm Completes Acquisition of NUVIA: Immediate focus on Laptops (Updated)

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Hey. Im Vonny.. I like to think im fun. Im completely OBSESSED with music. My Life! Recently met RJA. Best night of my life. I worship them. Litterly

Vonny!=]'s Blog

How i feel when i listen to The Red Jumpsuit Apparatus.

Posted on May 26, 2008 at 2:28pm 4 Comments

When i listen to RJA i get a fuzzy feeling in my belly, but its a good feeling. It makes me feel protected. And all my problems seem to dissapear. The lyrics "use me as you will, pull my strings just for a thrill. And i know i'll be okay, though my skies are turning grey" They make me feel like no matter WHAT i go through there is always a way to get over it. If ya get me?

Its just me and the music.

NOTHING else matters.

Its just Ronnie singing with all his… Continue

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At 7:07pm on August 21, 2008, Amrita said…
hi!! nice to meet u :)
At 3:47pm on July 8, 2008, Maggie!Mayhem! said…
hi! how are you?
At 12:59pm on May 31, 2008, Spencer said…
be happy you have a job.
At 4:40pm on May 29, 2008, Spencer said…
oh cool.
At 5:09pm on May 28, 2008, Spencer said…
bummer, what do you do?
At 4:29pm on May 27, 2008, Spencer said…
yeah it sucks
At 7:23pm on May 26, 2008, Spencer said…
not much you? im bored as hell.
At 3:02pm on May 26, 2008, Spencer said…
At 4:00pm on May 25, 2008, rjasnumberonefan said…
Welcome to The Alliance, Vonny!

Spotify http://spotify.redjumpsuit.com

Apple http://apple.redjumpsuit.com

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Amazon http://amazon.redjumpsuit.com

FREE http://free.redjumpsuit.com

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Cloth Baby

branding/ logo design • website design • e-commerce website

A fresh new Wangaratta business looking to reduce waste by promoting the use of and selling modern cloth nappies, was a fun (& nostalgic) project to work on despite no longer needing their services in our household!

Head ‘cloth mumma’ Emma was looking for a retro and colourful feel for their branding and we kept it simple with a three colour palette and two formats for the logo.


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SOLAS Marine Reflective Tape 30 foot rolls

SOLAS Marine Reflective Tape 30 foot rolls
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Price $39.99

1, 2 and 4 inch rolls x 30 feet. Reflexite SOLAS Coast Guard Approved Marine Tape is the toughest and brightest tape on the market. It has a very strong adhesive that will stick to almost anything. Our flexible SOLAS tape is specifically designed to increase the visibility of life jackets, ring buoys, survival suits, bouys, markers, rain suits, back packs, jackets and a variety of other objects in marine and land environments. It is also very popular for motorcycles and bikes due to its extreme reflectivity.

Reflexite FD1403 is an 8 mil thick, flexible, UV stabilized, weather-resistant polymeric film with prismatic retroreflective elements.  Since Reflexite tapes are made in a single layer they do not delaminate like other brands. This material is designed to withstand the harsh marine environment and extreme cold. FD1403 is IMO Type I and II certified and meets USCG requirements for SOLAS (Safety of Life at Sea).

On this page we carry the 30 foot rolls.  1" rolls are $39.99, 2" rolls are $54.99 and 4" rolls are $99.99. Use the drop down menu above to make your selection.

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REGINA -- A Saskatchewan ICU doctor is urging Premier Scott Moe to keep COVID-19 restrictions in place, as case numbers and hospitalizations continue to rise.

Despite growing concern of another wave of the virus hitting the province, Premier Scott Moe said he has fielded some questions on when restrictions will be eased.

"They want a road map on what happens when we get enough people vaccinated? What happens as we continue to follow the health measures that are in place, and when do is that going to happen?” Moe said Friday.

“I think it’s fair to have that conversation about what that might look like in the future and that’s a conversation that this government is going to be having."

While the Premier wouldn't provide a timeline for the current restrictions, NDP leader Ryan Meili said the situation in hospitals across the province is much worse than Moe is implying.

“At the very same time that the Health Minister was trying to tell our health critic and committee that everything’s fine in ICU in the province, Saskatchewan doctors were getting a presentation from the Health Authority that said we are leading the country in ICU admissions,” Meili said.

Doctors who work in these ICU's are scared of what the premier could be implying to residents.

"If they hear from him that we're talking about loosening restrictions, then they are less likely to follow Public Health Orders, they're less likely to understand that the situation is extremely dire and extremely difficult," Dr. Hassan Masri, an ICU Doctor in Saskatoon, said Saturday.

Dr. Masri said physicians are seeing unprecedented situations in hospitals across Saskatchewan and any easing of restrictions could have severe ramifications.

"Things are extremely difficult and every projection that we have suggests that a much more difficult time is to come. It’s not in the far future, rather in the near future, in the seven to 14 days that are coming,” Dr. Masri said.

While no restrictions have been lifted, the premier is urging residents to continue to abide by health orders already in place.

“We all in this province need to stay focused on precisely what matters in the here and now. That's following the public health orders that we have, when it’s your turn find your way to one of those vaccination clinics, take your shots if you’re willing," Moe said.

Dr. Masri is calling for more vaccinations for essential workers in grocery stores and health care workers.


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Our NEW Midlife Diet Plan!

Our midlife diet plan introduces you to the basics of clean eating. Clean eating involves eating food that is in its natural, unprocessed state. Whether it’s from additives in your diet or just daily life stress, our body builds up toxins that can prove harmful. This diet plan will help you flood your body with nutrients to get rid of those nasty toxins!

Not that organised? Don’t worry! We have you covered with plenty of recipes, shopping lists and an easy daily guide to clean eating and cleansing.

Download the guide and keep us updated on your progress on our Facebook page!

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