text:
Women Business Owners discuss money clutter

BINGHAMTON, NY – A discussion titled, “Secrets to Increase Your Self-Worth & Net-Worth,” will be the topic at the next Binghamton University Small Business Development Center’s Women Business Owners (WBO) roundtable, at 7:30 a.m. Wednesday, Sept. 26, at the Holiday Inn Express and Suites, 3615 Vestal Parkway East, Vestal, located behind the Plaza Diner.

Mary Wolfburg-Hlavacek, WBO member and business and marketing coach for women entrepreneurs, will speak about “money clutter” and provide tips for releasing “the negative charge around money.” She will discuss fears, doubts and anxieties relating to money and show how focusing on the positive can bring clarity to entrepreneur’s professional and personal life.

Wolfburg-Hlavacek has over 30 years of experience as a behavioral health nurse and has recently begun to focus on the field of emotional intelligence.

The roundtable costs $15 per person, payable at the door and includes a full breakfast. Attendees are encouraged to bring business cards and brochures to share.  Advance registration is required.  Call Binghamton University’s Small Business Development Center at (607) 777-4024 or
SBDC@binghamton.edu to register.

Last Updated: 9/17/13


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text:
Recreational leasing insurance for landowners?

Don Staples dstaples at
Thu Feb 12 11:26:56 EST 1998

ForestFair wrote:

> If there is a forest landowner organization in your state that offers an
> insurance policy to members who lease their land for recreational purposes,
> would you e-mail me with any information you have -- name and address of
> organization, how premium is determined, whether this benefit has been useful
> to members of the organization, etc?   Thanks!

Hunting lease insurance is a basic in Texas leasing, the minimum is
usually $1,000,000 umbrella, at $35 a head for the hunters on average.
It protects the landowner and landowner agents (yeah for the foresters!)
against suets  from hunters and trespassers.  I have insurance that runs
a $350 dollar minimum per year, up to ten hunters, from 10 to 20 hunters
it is at $45 per hunter same minimum, then after 20 hunters back to the
$350 minimum and $35 per each hunter past 10.

This is basic insurance, and not from any land owners association, and
my provider is Texas licensed only, although Hartford is the policy
carrier.  There is a general line company somewhere in Georgia that
offers this insurance, although at a slightly higher rate than the
above.  Check with your local forestry association,  and be prepared to
talk to a limited number of agencies, most wont know what your talking
about and will want a very healthy premium for non-specific liability.

The insurance has been used once in Texas, AFAIK, on a big lease in west
Texas where a hunter filed for an accident that was not supported by
testimony and evidence.  How effective it is I have no idea.  It is a
security blanket for landowners that should be part of the lease.  If
you day lease I feel that the cost of the insurace will go up
proportional to the number of folks you run through the gate.  Like any
insurance, the more exposure the higher the cost.

Insurance brings in another question.  How well is your property
identified?  Insurance may require a certain level of line
identification and specific acts to try and prevent trespass, such as
public notification, fencing, etc.

Don Staples
UIN 4653335

My Ego Stroke:

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text:
How to transform CRL-1999?

aeschba at aeschba at
Wed Sep 28 07:29:24 EST 1994

Dear netters,
I am trying to transiently transform human aorta smooth muscle cells (ATCC# CRL-
1999). I4ve tried Ca-phosphate, lipofection (DOTAB from Boeringer), as well as
DEAE-dextran-transformations, but I haven't obtained any expression with various
vectors (CMV- and SV40-promoter driven luciferase). I've tried different time
points after transformation, as well as different DNA concentrations. The used
methods are probably simply very harsh for this cell type and basically kill the
cells. MCF-7 cells, on the other hand, did transform nicely using the same
techniques in my hands.
Does anybody have experience with CRL-1999 cells? How do you transform these
smooth muscle cells? Any comments and suggestions are welcomed. A summary of
replies will be posted on the net. Thanks

Dr. Roger Aeschbacher
c/o CIBA
Pharma Research
Mauerstr. K 681-304
4002 Basel

E-mail: aeschba at

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text:
Tricks for pipetting detergents??

Bart Sefton bart_sefton at
Mon Aug 19 19:33:22 EST 1996

In article <32177009.0 at>, hutchins at (Gary Smyly)

> Paul Wakenight (pw at wrote:
> : I'm sure everyone has tried to pipette NP40, etc.  What a mess.
> : Outside of using a graduated cylinder, is there anyway to do this
> : accurately?
> :
Sorry I missed the beginning of this.  I hope I'm not repeating anything.
I think that the best thing to do is to make a 10-20% stock solution by
weighing the detergent out in the container you want to use to dissolve
it.  This way, the only thing that matters is what gets into your beaker,
not how much entered your pipet.  If you're extremely fastidious, you can
calculate the volume delivered from the density of the detergent, but this
almost certainly is not of much importance.

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text:
Transfection of HepG2 cells

Ram krishna at
Fri Jul 24 07:31:14 EST 1998

Has anybody transfected HepG2 cells with SV40-CAT or CMV enhanced
tk-CAT? I have done several transfections and I've used the CAT ELISA
kit by Boehringer-Mannheim to detect CAT activity, my readings are very
low for CAT, but are good for beta-gal, any ideas?
thanks for any advice, kathy

I tried transfecting HepG2 cells with a SV40 CAT and assayed using BM
CAT ELISA kit. The SV40 enhancer gave me good activity but when I
cotransfected a CMV based expression plasmid along with CAT reporter
construct I didn't get any activity at all even though these reporters
and the expression plasmids have been tested before The CMV-Beta gal
plasmid I use does express.

I did all the experiments using CaPO method.

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text:
[FUN] Dumbest lab experience?

Richard P. Grant rpg14 at yahoo.co.uk.invalid
Mon Dec 18 12:29:01 EST 2000

In article <3A3E44FF.B3516B75 at immv.unizh.ch>,
rogerrabbit at rzu-mailhost.unizh.ch wrote:

> what fun we are having here, and if anyone who is not in science read
> this, he would be reassured how nerdy scientists are.

This thread reminds me of one of the 'Dilbert' cartoons where they're
laughing over someone mistaking 'gigabit' for 'megabit'.

Richard P. Grant                                       MRC Lab of Mol Biol
rpg 'at' mrc-lmb.cam.ac.uk     http://www2.mrc-lmb.cam.ac.uk/personal/rpg/
System Defenestrator

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text:
Qualified physician parasitologists

I82GO i82go at aol.com
Wed Feb 19 21:29:06 EST 1997

Dear Mr. Armitage,

I am replying to the letter you posted through the news group.  I have a
relative who may be experiencing the effects of a parasitic infection.  I
like yourself have found little help from our family practitioner.  I
would much appreciate any knowledge you have acquired about treatment
centers throughout the United States that specialize in the diagnosis and
treatment of such infections.

Thanyou for your cooperaton.

W. Banks

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text:
Henriette Kress HeK at
Mon Apr 1 14:05:31 EST 1996

On Sun, 31 Mar 1996 20:53:30 GMT, $LANGLRW at (LANGLOIS) wrote:

>Collector of wild plants wishes to know markets for goldenseal.
>Please quote prices and buyers.  Collector has access to wild stock in
>Northern Manitoba, Canada.  seeds, roots (fresh and dried), plant
>biomass (dried).

Can't say how abundant goldenseal is in your neck of the woods.
However, here's the goldenseal part of the medicinal herbfaq, so you know why
NOT to wildcraft anything but the seeds of this plant, and even that ethically:

2.1.19 Golden Seal appeal - and Goldthread too
Please use alternatives to Goldenseal (Hydrastis canadensis) whenever
possible. If you have to use Goldenseal please grow your own.

Here's why:

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text:
Join for Free!
121234 members

Human Reproduction System

Human Anatomy, Physiology, and Medicine. Anything human!

Moderator: BioTeam

Human Reproduction System

Postby Asanii » Tue Aug 25, 2009 5:25 pm

I am having trouble with a question in one of my lessons, the question is...

Explain why it is necessary that estrogen and progesterone inhibit the secretion of FSH and LH

I know that high levels of Estrogen/Progesterone suppress the release of GnRH providing a negative feedback control of hormone levels, to suppress further production of FSH and LH but why do they inhibit the secretion of FSH and LH?

Any help would be greatly appreciated.

Posts: 7
Joined: Sun Jul 05, 2009 1:56 am

Postby mande » Wed Aug 26, 2009 10:15 am

FSH stimulates the development of follicles while LH stimulates the remaining follicle to develop into the corpus luteum and also for ovulation to occur.

The negative feedback mechanism whereby the secretion of FSH and LH is halted occurs because the estrogen and progesterone now move in to stimulate the uterine wall to become progressively thicker thus the need for the development of any more follicles is unnecessary.

Both oestrogen and progesterone alone signals the hypothalamus and the pituitary gland to stop further secretion of FSH and LH hence the levels of both FSH and LH would dramatically fall and finally plateau after the 14th day.
Posts: 2
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text:
Blood Plasma

Plasma that separates from blood in coagulation.The water substance in which all blood cells are suspended in, until movement by the heart pushes them along the bloodstream. Blood Plasma consists 90% water and 10% of other compound and elements that each play role within the body.

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text:
Article Type: Book review
Subject: Books (Book reviews)
Author: Silkenat, David
Pub Date: 06/22/2010
Publication: Name: Journal of Social History Publisher: Journal of Social History Audience: Academic Format: Magazine/Journal Subject: History; Sociology and social work Copyright: COPYRIGHT 2010 Journal of Social History ISSN: 0022-4529
Issue: Date: Summer, 2010 Source Volume: 43 Source Issue: 4
Topic: NamedWork: Upbuilding Black Durham: Gender, Class, and Black Community Development in the Jim Crow South (Nonfiction work)
Persons: Reviewee: Brown, Leslie
Accession Number: 230778730
Full Text: Upbuilding Black Durham: Gender, Class, and Black Community Development in the Jim Crow South. By Leslie Brown (Chapel Hill: University of North Carolina Press, 2008. xiii plus 451 pp. $24.95).

In her 2004 Presidential Address to the Organization, of American Historians, Jaoquelyn Dowd Hall urged historians to probe more deeply into what she described as the "Long Civil Rights Movement," to move beyond a conceptualization that limited the struggle for black equality to the decade between Brown v. Board of Education (1954) and the Voting Rights Act (1965), and to construct narratives that emphasize individual and collective African American agency in the lengthy struggle against Jim Crow. (1) In this nuanced, deeply researched, and long awaited study, Leslie Brown examines how African American residents of Durham, North Carolina sought to construct social and economic institutions between emancipation and the New Deal. Central to Brown's argument is the idea that "upbuilding of Black Durham," a phrase she borrows from W.E.B. Du Bois, manifested internal tensions within the African American community over class, generation, and especially gender.

Black leaders and intellectuals heralded Durham as an exemplar of African American economic and social achievement. Booker T. Washington, W.E.B. Du Bois, and E. Franklin Frazier praised the city as the "Capital of the Black Middle Class" and as a symbol of the "progress of the Negro American." The success of Durham's black community, Brown argues, comes in large part from a willingness by the city's black leadership to accept segregation and construct, financial and social institutions "behind the veil" of Jim Crow. As a consequence, black financial institutions, such as the Mechanics and Farmers Bank and North Carolina Mutual Life Insurance Company, and social institutions, such as Lincoln Hospital, the Tubman YWCA, and the North Carolina College for Negroes, survived when comparable institutions in other cities became targets for white violence.

Despite the progress of the black community in Durham, the benefits of upbuilding were not distributed equally. Black women, particularly working class black women, did not benefit as much as black men from Durham's black institutions. Working in tobacco factories, as domestic servants, and as teachers, working class black women who suffered the most under Jim Crow found that Durham's African American elite often stymied their efforts for equal wages and undermining unions. The significantly smaller number of well-educated black women who worked at North Carolina Mutual and other financial institutions also found themselves under the watchful eye of their employers, who associated propriety and respectability with uplift and demanded a strict observance of proscribed gender roles. Younger African Americans who aligned themselves with the NAACP and sought to combat Jim Crow in the courts also found their efforts obstructed by the established black elite who had cultivated and defended a detente with Durham's white leaders.

Given Brown's attention to detail, two lacunae in Upbuilding Black Durham are worth noting. First, despite the detailed analysis the Brown provides for working class, middle class, and elite black women and for a number of prominent black men, she does not offer much of a portrait of working class black men. While Brown notes that Durham's black population was predominantly female, the absence of working class black men (outside of their role as soldiers in World War I) is striking. Second, Brown never provides a thorough explanation for the book's chronological hounds and its somewhat abrupt ending in the 1930s. The reader is left wondering how the tensions expressed in Upbuilding Black Durham contributed to or hindered later civil rights efforts. While Brown makes allusion to their effect in the conclusion, more direct connections would have been illuminating. These minor caveats do not significantly detract from an otherwise excellent book.

Upbuilding Slack Durham provides a well-researched, textured, and eloquent community study that highlights the forms of cooperation and conflict between white and black Durhamites and within Durham's black community. This useful and stimulating addition to the literature should be read by those interested in the complexity of the African American experience under Jim Crow.

(1.) Jacquelyn Dowd Hall, "The Long Civil Rights Movement and the Political Uses of the Past," Journal of American History (Match 2005).

David Silkenat

North Dakota State University
Gale Copyright: Copyright 2010 Gale, Cengage Learning. All rights reserved.


text:
Document Detail

Chicken embryo as an experimental model for the study of gastroschisis.
MedLine Citation:
PMID:  18552995     Owner:  NLM     Status:  MEDLINE
PURPOSE: To reproduce the experimental model of gastroschisis in chicken embryos and to prove that the histopathological changes that occur in this model can be compared to those in human gastroschisis. METHODS: A total of 278 Leghorn hen (Gallus domesticus) eggs were used. The embryos were divided into three groups: the gastroschisis group, in which the umbilical cord was opened through an orifice made in the eggshell, and the intestinal loops were exposed to a mixture of amniotic liquid and allantoid; the mixture group, in which the amniotic fluid and allantoid were simply mixed without manipulating the umbilical stump and without exposing intestinal loops; and the control group which consisted of normal embryos in which no procedure was performed. The procedures were performed on the 13th day of embryo development and the study ended on the 19th day, when the intestinal loops of the embryos were removed and sent for conventional histological study and digital morphometric analysis. RESULTS: At the end of the experiment, 23 live embryos were obtained in the gastroschisis group (11.1% survival), and 18 of these presented exposed intestinal loops (8.7% success). The embryos of the gastroschisis group weighed less than those of the other two groups. The gastroschisis group also developed intestinal changes consisting of the thickening of the intestinal wall, inflammatory infiltration of the serosa and mucosa, ischemic changes in the intestinal wall and formation of a fibrin layer over the loops. These findings are characteristic of human gastroschisis and were not observed in the two other groups studied. CONCLUSION: The experimental model in chicken embryos proved able to reproduce the intestinal changes of human gastroschisis.
Carlos André Tarrio Gandara; Eduardo Spadari Araújo; Ubirajara Indio Carvalho da Motta
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Publication Detail:
Type:  Journal Article
Journal Detail:
Title:  Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia     Volume:  23     ISSN:  0102-8650     ISO Abbreviation:  Acta Cir Bras     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-06-16     Completed Date:  2009-07-16     Revised Date:  -
Medline Journal Info:
Nlm Unique ID:  9103983     Medline TA:  Acta Cir Bras     Country:  Brazil
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM
Caxias do Sul, RS, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chick Embryo*
Disease Models, Animal*
Enteritis / pathology
Gastroschisis / pathology*
Intestinal Mucosa / pathology
Intestine, Small / pathology
Serositis / pathology

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text:
Document Detail

Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis.
MedLine Citation:
PMID:  23292869     Owner:  NLM     Status:  In-Data-Review
MicroRNA-34 family has anti-proliferative and apoptotic roles. Recent studies have shown that p53 upregulates miR-34 family leading to direct repression of several key oncogenes. Inactivation of miR-34a has been reported in multiple types of malignancies including breast cancer. The critical role of miR-34a in p53-mediated cell cycle arrest and apoptosis invokes studies focusing on the specific role of miR-34a dysregulation in carcinogenesis. While presence of p53 mutations has frequently been described in breast cancer, still most of the breast tumors do not show any variation in the p53 coding sequence or protein expression. Therefore, it is important to clarify possible involvement of other mediators of p53 pathway in breast cancer. In this study, expression of mature miR-34a in breast tumors with wild-type p53 was investigated in order to find any correlation between dysregulation of miR-34a expression and breast cancer. In about 40 % of the wild-type p53 samples, miR-34a was significantly downregulated. Neither hypermethylation of the miR-34a promoter nor genetic variations of the p53-binding site were detected in tumor samples with downregulated miR-34a. This study has provided evidence that miR-34a expression can be affected in a significant proportion of breast tumors independent of p53. Furthermore, downregulation of miR-34a was significantly associated with metastasis, while there was a significant correlation between upregulation of miR-34a and non-metastatic condition indicating a protective role for miR-34a against more invasive disease. Knowledge of miR-34a status may provide additional useful information regarding the nature of breast tumors, especially when p53 testing does not show any aberration.
Arash Javeri; Massoud Ghaffarpour; Masoumeh Fakhr Taha; Massoud Houshmand
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Publication Detail:
Type:  Journal Article     Date:  2013-01-06
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  30     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2013 Mar
Date Detail:
Created Date:  2013-01-07     Completed Date:  -     Revised Date:  -
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States
Other Details:
Languages:  eng     Pagination:  413     Citation Subset:  IM
Department of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), P.O. Box: 161-14965, Tehran, Iran,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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text:
Document Detail

Honey for nutrition and health: a review.
MedLine Citation:
PMID:  19155427     Owner:  NLM     Status:  MEDLINE
Due to the variation of botanical origin honey differs in appearance, sensory perception and composition. The main nutritional and health relevant components are carbohydrates, mainly fructose and glucose but also about 25 different oligosaccharides. Although honey is a high carbohydrate food, its glycemic index varies within a wide range from 32 to 85, depending on the botanical source. It contains small amounts of proteins, enzymes, amino acids, minerals, trace elements, vitamins, aroma compounds and polyphenols. The review covers the composition, the nutritional contribution of its components, its physiological and nutritional effects. It shows that honey has a variety of positive nutritional and health effects, if consumed at higher doses of 50 to 80 g per intake.
Stefan Bogdanov; Tomislav Jurendic; Robert Sieber; Peter Gallmann
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Publication Detail:
Type:  Journal Article; Review
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  27     ISSN:  1541-1087     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  2008 Dec
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-03-03     Revised Date:  -
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  United States
Other Details:
Languages:  eng     Pagination:  677-89     Citation Subset:  IM
Swiss Bee Research Centre, Agroscope Liebefeld-Posieux Research Station ALP, Bern, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carbohydrates / analysis
Clostridium botulinum / isolation & purification
Glycemic Index
Honey* / adverse effects,  analysis,  microbiology
Sweetening Agents / chemistry*,  pharmacology*,  therapeutic use
Reg. No./Substance:
0/Carbohydrates; 0/Sweetening Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nonalcoholic fatty liver disease in children.
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text:
Document Detail

Inspiratory muscle relaxation rate after voluntary maximal isocapnic ventilation in humans.
MedLine Citation:
PMID:  1907603     Owner:  NLM     Status:  MEDLINE
We have investigated whether the capacity of the inspiratory muscles to generate pressure and flow during a ventilatory load is related to changes in inspiratory muscle relaxation rate. Five highly motivated normal subjects performed voluntary maximal isocapnic ventilation (MIV) for 2 min. Minute ventilation and esophageal, gastric, and transdiaphragmatic pressures were measured breath by breath. We observed that ventilation, peak inspiratory and expiratory pressures, and inspiratory flow rate declined from the start of the run to reach a plateau at 60 s that was sustained for the remainder of the exercise. In a subsequent series of studies, MIV was performed for variable durations between 15 and 120 s. The normalized maximum relaxation rate of unoccluded inspiratory sniffs (sniff MRR, %pressure loss/10 ms) was determined immediately on stopping MIV. Sniff MRR slowed as the duration of MIV increased and paralleled the decline in inspiratory pressure and ventilation observed during the 2-min exercise. No further slowing in MRR occurred when ventilation became sustainable. We conclude that, during MIV, the progressive loss of ventilation and capacity to generate pressure is associated with the early onset and progression of a peripheral fatiguing process within the inspiratory muscles.
D A Mulvey; N G Koulouris; M W Elliott; C M Laroche; J Moxham; M Green
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Publication Detail:
Type:  Journal Article
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  70     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1991 May
Date Detail:
Created Date:  1991-09-09     Completed Date:  1991-09-09     Revised Date:  2013-09-26
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES
Other Details:
Languages:  eng     Pagination:  2173-80     Citation Subset:  IM
Respiratory Muscle Laboratory, Brompton Hospital, London, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carbon Dioxide
Electric Stimulation
Fatigue / physiopathology
Muscle Relaxation / physiology
Phrenic Nerve / physiology
Respiratory Mechanics / physiology*
Respiratory Muscles / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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text:
Document Detail

Nonoxidative metabolism of 2-butoxyethanol via fatty acid conjugation in Fischer 344 rats.
MedLine Citation:
PMID:  8968408     Owner:  NLM     Status:  MEDLINE
Nonoxidative metabolism of ethylene glycol monobutyl ether (2-butoxyethanol or BE) via fatty acid conjugation was studied in the liver of Fischer 344 male rats following a single oral administration of 500 mg/kg body weight [ethyl-1,2-14C]BE (70 microCi/kg). Animals were killed 2 h after the treatment, hepatic lipids extracted, and the neutral lipids were separated using solid-phase extraction. The neutral lipid fraction was subjected to preparative thin-layer chromatography, and the esters corresponding to the relative flow of authentic fatty acid 2-butoxyethyl esters were recovered and analyzed by reversed-phase high-performance liquid chromatography (HPLC) using methanol-water (37:3, v/v) as solvent. Approximately 85% of the 14C label present in the ester fraction was coeluted at retention times corresponding to the different fatty acid 2-butoxyethyl ester standards. The radioactive fractions were analyzed by electron impact mass spectrometry. Molecular ion peaks and fragmentation patterns similar to that of 16:0, 18:0, 18:1, 18:2, and 20:4 fatty acid 2-butoxyethyl ester standards were detected in the corresponding radioactive HPLC fractions. Fatty acid ethyl ester synthase (FAEES), purified from the rat liver microsomal fraction, was also found to catalyze the formation of 18:1 fatty acid 2-butoxyethyl ester. These studies demonstrate that BE is metabolized nonoxidatively via conjugation with long-chain fatty acids, and the formation of these esters appears to be catalyzed by the enzyme(s) involved in fatty acid conjugation of xenobiotic alcohols. However, the biological significance of BE conjugation with fatty acids remains to be investigated.
B S Kaphalia; B I Ghanayem; G A Ansari
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Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  49     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1996 Dec
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2007-11-14
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES
Other Details:
Languages:  eng     Pagination:  463-79     Citation Subset:  IM
Department of Pathology, University of Texas Medical Branch, Galveston 77555-0609, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acyltransferases / metabolism
Administration, Oral
Carbon Radioisotopes / metabolism
Chromatography, High Pressure Liquid / methods
Esters / analysis,  chemical synthesis,  chemistry*
Ethylene Glycols / administration & dosage,  metabolism*
Fatty Acids / metabolism*
Liver / chemistry,  metabolism
Rats, Inbred F344
Solvents / administration & dosage,  metabolism*
Grant Support
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Esters; 0/Ethylene Glycols; 0/Fatty Acids; 0/Solvents; 111-76-2/n-butoxyethanol; EC 2.3.-/Acyltransferases; EC acyl ethyl ester synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Building a Business Case for Biopharmaceutical QbD Implementation (Peer Reviewed)

The author describes a methodology for developing a per product qualitative and semi-qualitative business case for applying QbD to a biopharmaceutical product.
Aug 01, 2012
Volume 25, Issue 8

The aim of this paper is to describe a methodology for developing a per product qualitative and semi-quantitative business case for application of quality-by-design (QbD) for a biopharmaceutical product. Previous authors have not frequently approached the business case topic on a per product basis. Instead, they have examined benefits across a portfolio for a company or aggregated across the pharmaceutical industry as a whole (1). In contrast, this effort focuses on a per product basis of business benefit estimate.

The primary purpose of a quality-by-design (QbD) business case is to demonstrate and elucidate the expected value that QbD is to deliver (2). Lack of belief in QbD's business case has been cited as a key challenge within pharmaceutical companies preventing successful QbD implementation (3, 4). Regardless, many companies already have adopted QbD concepts as their standard business practice for process and analytical development execution (5). Recently, momentum has increased based on QbD's recognized role as a new approach to improve product manufacturing and quality (6).

In 2010, FDA approved only six new biologics, giving few opportunities for QbD submissions (7). Overall, there have been few biopharmaceutical QbD submissions to date despite seven elapsed years from the first draft of the International Conference on Harmonization (ICH) Q8 guidance in November 2004 and longer since the first mention of risk-based quality approaches by FDA's Janet Woodcock in October 2002 (8, 9). Although submissions containing enhanced development data and parameter interaction studies have increased, there have been few, if any, design-space claims (10). Several biopharmaceutical QbD efforts have focused on retrospective QbD for licensed processes, leveraging larger amounts of manufacturing data, experience, and knowledge compared with processes for pipeline products (5).

Often, business cases are based on return-on-investment (ROIs) with minimal ROIs of less than a few years considered most attractive. During the early stages of QbD introduction, the business case was based on qualitative potential benefits in a few key areas: minimized manufacturing-scale development studies, fewer quality issues, greater flexibility to optimize postlicensure, improved patient-focus for the product, more clinically meaningful product specifications, and reduced effort in regulatory interactions. The business case needs to be updated based on the current level of biopharmaceutical QbD implementation maturity, considering that some of the potential benefits achievable for current pipeline products now may be substantially different.

Costs of goods

Selling costs for a product are lowered by lowering production costs, albeit not proportionally. In turn, production costs are fixed by Phase III clinical production processes. These processes are often developed to meet tight clinical trial timelines that do not permit substantial optimization for efficient licensed manufacturing, nor the ability to incorporate new process or analytical technologies (1). Simulated production costs, including indirect/fixed costs, for a typical aglycosylated protein ranged from $100–800/g depending on production host and selected yield assumptions (11). Lower production costs arise from reduced wastes (i.e., fewer rejected batches, deviations, or reprocessing), higher yields, and better utilization of assets (ie, greater overall equipment effectiveness) (12, 13). Specifically, the true aggregated cost of poor quality (COPQ) can often be greater than the more readily quantifiable cost of waste (14).

Development timelines

Development timelines directly affect the product's net present value (NPV). In one model, a 6-month delay to launch (type of product not given) translated to a $100-million loss in NPV (15, 16). In contrast, an 18 month acceleration increased NPV by $180 million by the model (15, 16). The average internal rate of return (RIR) for R&D for a biologic is 13% and NPV is $1.26 billion (15, 16).One author estimates a cost of $1 million in expenses for each day of product development and > $0.5 million in losses for each day delay in product commercialization (17).

Later parts of clinical phase timelines to final filing are primarily affected by assembly of clinical data, but timelines in early clinical phases can be highly affected by chemistry, manufacturing, and controls (CMC) activities. Even the availability of nonclinical bulk material can be rate-limiting because often the goal is to start pharmacology and toxicity studies as soon as possible (18). In addition, the entire timeline benefit associated with reducing CMC risks likely is under-estimated because some lurking CMC issues never are uncovered when clinical issues halt product candidate development.

Quantifying cost and timeline benefits

Table I: Sample matrix for quantifying biopharmaceutical QbD benefits.
Table I shows a sample matrix of QbD-related benefits and proposed steps for how to evaluate them. Ultimately all benefits can be related to a cost, either directly or indirectly, because timeline extensions are converted into opportunity costs. Direct costs can further be broken down into cost reductions or cost avoidance, based on the ability to either allocate fewer resources initially to complete a deliverable or request fewer resources to revise or redo a deliverable. Overall, the cost avoidance category serves as the most frequently estimated QbD benefit, primarily because it focuses on minimizing additional unexpected resources not already allocated.


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From the Editor: After Zheng

Aug 01, 2007
Volume 20, Issue 8

Laura Bush
The execution of Zheng Xiaoyu, the corrupt head of China's State Food and Drug Administration, was a shock. Just weeks earlier, in writing for our July issue about the diethylene glycol contamination of excipients produced in China, I said the Chinese government's response to several related cases had ranged from "obstructive to inadequate." For example, Chinese officials declared that the deadly chemical was not toxic and was therefore permitted to be used as an ingredient in toothpaste. That they should turn suddenly to crack down so severely on their agency's corruption was, therefore, unexpected.

What Zheng did was itself shocking. In a country where the average worker earns about $2,000 a year, Zheng accepted bribes totalling more than $850,000. In return, he approved thousands of untested medications. All told, the agency approved 150,000 drugs under Zheng's tenure. (In a typical year, the US FDA approves fewer than 150). As a result of those approvals of fraudulent drugs, countless Chinese patients died or became seriously ill.

And all this happened on the watch of a man who started his career as a reformer. A recent New York Times article chronicles Zheng as an idealistic young man who eventually pushed for the creation of a federal food and drug oversight body, of which he became the director in 1998. He established good manufacturing standards and began to shut down companies that did not meet them. But at some point, Zheng changed. The cause remains a mystery. Was he overwhelmed by a system that is corrupt on many levels? Or was it just simple human greed?

If what happened to Zheng personally is impossible to ascertain, interpreting the government response is not much easier. It may have been only a symbolic move intended to show Western countries that China is serious about meeting international quality standards, following a series of recent contamination cases involving cough syrup, toothpaste, pet food, and seafood—all from China.

Perhaps the government was trying to send a signal domestically indicating that the pharmaceutical industry truly is going to have to clean up its act. Because clearly, the corruption of China's food and drug sectors is not limited to one man. It occurs at many levels, including the powerful regional politicians who defend companies in their areas against federal policy enforcement.

Likewise, real reform will require the efforts of many. It will take courageous reformers willing to put themselves on the line to speak the truth. It will take external pressure, both moral and economic, from foreign trading partners and even consumers, unwilling to overlook unscrupulous practices or accept poor quality goods in the realization that inexpensive is not always a bargain. And it will require significant political will in China to truly work toward change, including shifting the balance of power between the local and national levels.

After Zheng, the question that lingers is whether China is indeed on the path to reforming its pharmaceutical sector. I hope so. But only time will tell.

Laura Bush is the editor in chief of BioPharm International,


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Air Science USA Release: New Purair 5 Ductless Fume Hood

2/26/2013 11:53:02 AM

February 26, 2013 -- The NEW PURAIR 5 Ductless Fume Hoods from Air Science USA feature a high level of operator protection where routine work is being carried out.

The units exceed OSHA, ANSI and all relevant international standards.

The Ductless design eliminates installation costs and allows the unit to be positioned over a sink or benchtop apparatus.

There are three models available with a choice of 24", 36" or 48" widths.

The units operate at low noise levels and because they recirculate, they do not exhaust expensive conditioned and/or heated air into the atmosphere.

A face velocity of 100 fpm ensures containment of fumes and particulates for operator protection. An alarm alerts the operator when the airflow falls to an unacceptable level.

The unit can be placed on any bench top, and an optional polypropylene spillage tray can be provided when required. The rear of the unit has lighting to illuminate the work surface.

All mechanisms in the head section are on the clean side of the filter, with the switches and electrical components being isolated from any contamination.

The patented filter clamping mechanism allows for the filter to be easily installed and ensures an even seal at the filter face at all times to prevent bypass leakage.

The main filter can be chosen from 14 different types of carbon, which include specialty media for vapors of organics, solvents, acids, mercury and formaldehyde. HEPA filters for particulate filtration are also available to suit your application needs.

Typical applications for the Purair 5 include histology, powder weighing and sampling prep work.

For additional information on Purair Ductless Fume Hoods, call, visit the website, or email Air Science USA.

Air Science USA

PO Box 62296

Fort Myers, Florida 33906 USA

Toll Free: 800-306-0656

Phone: 239-489-0024

Fax: 800-306-0677

E-mail: info@airscience.com

Web: www.airscience.com

Client Contact:

Paul Chambre

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Enigma Diagnostics Expands Its US and European Executive Management Teams; Opens US Headquarters in San Diego, California

11/25/2009 7:12:41 AM

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OXFORD, England and SAN DIEGO, Nov. 24 /PRNewswire/ -- Enigma Diagnostics Limited, the decentralised and point-of-care molecular diagnostics company, announced today four senior appointments for its US and European offices.

Dr. Jorge Garces will lead the US team as President and CEO with Greg Hamilton, Chief Operating Officer and Chief Financial Officer, USA. Stationed at Enigma's new U.S. headquarters in San Diego, California, the headquarters will expand rapidly with a recruitment programme planned for assay development, R&D and commercial activities.

Dr. Garces joins the Enigma team after serving as Vice President of R&D and Site Operations Manager at Hologic, Inc. where he managed the R&D, clinical and manufacturing business unit in Madison, WI. During his tenure at Hologic, Dr. Garces was responsible for the product development of the company's molecular diagnostics business and clinical trial strategies, which attained FDA approval for groundbreaking Cystic Fibrosis and HPV products.

Dr. Garces holds a Ph.D. in cell and molecular biology from the City University of New York. He received his post-doctoral fellowship training at the University of Massachusetts Medical School specialising in neurobiology, biochemistry, cell and molecular biology.

Mr. Hamilton joins the Enigma team after serving as Vice President of Operations, Planning and Analysis for Hologic, Inc.'s business unit specialising in women's healthcare products. Formerly Vice President of Finance and Operations at Third Wave, he was instrumental in developing the company's strategy, leading the sale of the company to Hologic, Inc. for $582M in 2008.

Prior to Hologic, Mr. Hamilton was CFO at iLeo, Leo Burnett's former direct marketing company, where he increased its business revenue to double-digit growth and an 11x increase in profitability.

Mr. Hamilton graduated from Purdue University in 1992 with a Bachelor of Science degree in finance and earned an MBA in finance, strategy and entrepreneurship from the University of Chicago Booth School of Business.

Also joining the management team is Nick Williams, appointed as Chief Financial Officer Europe, and Darren Hall, appointed Chief Operations Officer Europe.

Mr. Williams joins Enigma with 15 years of experience in finance leadership. Most recently, he completed a second exit process with Alchemy Partners as CFO of 100m Pounds Sterling IT services group, Calyx. At Alchemy-backed industrial products group Truflo International plc, he was part of the team that achieved a 66% annual return to investors. Earlier in his career, Mr. Williams held a number of senior finance roles during a period of rapid growth with Biocompatibles International plc, a UK medical devices group. As Finance Director, he played a key role in the sale of Biocompatibles' contact lens business to Cooper Companies for over 110m pounds. Mr. Williams is a member of the Institute of Chartered Accountants in England and Wales and qualified with KPMG.

Mr. Hall joins Enigma with 12 years of extensive international experience in the healthcare and medical devices sectors. He achieved a successful track record at board level while at Graseby Plc, Smiths Industries and Biocompatibles Plc. During this time, he was heavily involved in a number of successful acquisitions and divestments. Mr. Hall has specific expertise in bringing new products to market and in developing successful operational and supply chain strategies.

Most recently, Mr. Hall was Managing Director of the Singapore based start-up Clearlab International, a subsidiary of 1800 Contacts Inc., where he led the successful business scale up. During his tenure, following the acquisition of a UK based manufacturing business; Mr. Hall led the successful transfer of manufacturing and technology from the UK to Singapore. Working closely with Mr. Williams, he successfully prepared the Clearlab business for acquisition leading to a successful exit for 1800 Contacts Inc.

John McKinley, Chairman & CEO of Enigma Diagnostics, said, "The expertise which each of Jorge, Greg, Nick and Darren bring to Enigma underpins our rapid operational and infrastructural growth across Europe and the USA, essential to delivering a leadership position in global decentralised diagnostic testing. We welcome them to our management team."

About Enigma Diagnostics Limited

Enigma Diagnostics Limited specialises in developing next generation rapid molecular diagnostic instrument platforms for decentralised and point-of-care settings.

Enigma's innovative and proprietary technology combines the speed and sensitivity of real-time PCR (polymerase chain reaction) with the simplicity needed for decentralised and point-of-care testing providing results from a raw sample in less than 60 minutes.

The Company is targeting a number of multi-billion pound markets in the Clinical and high-value Applied Markets. Enigma's commercialisation strategy is to produce a continuous flow of market leading rapid diagnostic point-of-care instruments and assay panels, based on Enigma's innovation and proprietary technologies and underpinned by its broad intellectual property portfolio.

Enigma's majority shareholder is Porton Capital, a private equity house, which has supported Enigma's development since incorporation in 2004.

For more information visit www.enigmadiagnostics.com

UK Contact:

Enigma Diagnostics Deborah Cordingley deborah.cordingley@enigmadiagnostics.com +44 1980 590131

US Contact: Tiberend Strategic Advisors, Inc. 212-827-0020 Tamara Bright tbright@tiberendstrategicadvisors.com Chiara DePaolo cdepaolo@tiberendstrategicadvisors.com

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Sharp Clinical Services [UK] Ltd. Expands Their Capabilities
10/29/2012 1:43:03 PM

CRICKHOWELL, UK--(Marketwire - October 29, 2012) - Sharp Clinical Services [UK] Ltd. has expanded its over-encapsulation capabilities. This will provide better service to their customers' needs. The investment is in response to increased customer demand for over-encapsulation to support their clinical trials.

Ian Morgan, General Manager of Sharp Clinical Services [UK] Ltd. facilities, said, "The expanded capability will ensure we have the flexibility and speed in an area where Sharp has seen a significant increase over the last 12 months."

Sharp Clinical Services has been serving the Americas, Europe, and the rest of the world with diverse levels of integrated global clinical trial materials, services and project management.

For more information about Sharp Clinical Services [UK] Ltd., please visit our website at

Media Contact:

Ian Morgan
General Manager
Email: Email Contact
Tel: +44 (0) 1873 813583
Fax: +44 (0) 1873 810836
Mobile: +44 (0) 7791 622310

Sharp Clinical Services [UK] Ltd.
Elvicta Business Park
Wales NP8 1DF
United Kingdom


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Bench Press: BioWorld Looks at Translational Medicine

Monday, November 12, 2012
Researchers at the University of Wisconsin at Madison mapped changes to the mitochondrial proteome and its phosphorylation in lean and obese mice at different ages, as well as during fasting and refeeding after a fast.

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Rodent eradication in Palau shows early signs of success

Rodent eradication on Kayangel Atoll, Palau already showing early signs of success.
Rodent eradication on Kayangel Atoll, Palau already showing early signs of success.
By PCS, Wed, 28/09/2011 - 23:01

After years of planning a rodent eradication operation on Kayangel Atoll, Palau, has just been completed and is already showing early signs of success.

“So far, there have been no reports of rats on any of Kayangel’s four islands”, said Anu Gupta – Conservation and Protected Areas Program Director for Palau Conservation Society (PCS / BirdLife Partner). “Within just weeks of the operation there have already been reports that agricultural harvests have improved, with bananas and coconuts harvested without any rat damage. Although an official declaration of success will not come for at least a year, we are cautiously optimistic”.

Kayangel State is an atoll at the northern end of Palau. Four islands make up the atoll, including the Important Bird Area of Ngeriungs Island and three other islands of Orak, Ngerebelas, and Kayangel island. Together the four islands cover 160 hectares, and are home to Palau’s biggest population of Micronesian Megapode Megapodius laperouse – an Endangered bird on the IUCN Red List that triggered the rodent eradication project.

The rodent eradication operation was led by the PCS and involved distributing poison bait widely across the atoll. The greatest factor in the success of the project was the high level of voluntary community participation. A total of 60 community members from Kayangel – along with six volunteers, eight PCS staff and one BirdLife Pacific Partnership staff - participated in the field operations.

It was a very demanding and complex operation which carefully balanced the needs of the local people, endemic birds and unpredictable weather conditions. In order to manage it, half of PCS’s small staff relocated to Kayangel during the project.

“So far, the field component of the project has required 885 person-days of work”, added Anu. “PCS relied on Kayangel-based community leaders during the preparation and implementation phase and for treatment in culturally taboo areas”.

Community members have been vocal in expressing their support for the project. Rats, in particular, have had a huge negative effect on agriculture, and with them apparently now gone, the community has excitedly made plans to replant numerous crops, including corn, tapioca, cucumber, and other vegetables.

“Three decades ago Kayangel was known for its corn crop, and the state featured a specialty corn dish in cultural events. However, an explosion in rats in the 1980s led to a decline in corn crops. Kayangel community members are particularly excited about replanting corn and once again being able to make their unique dish”, noted Anu.

In addition to distributing rat poison, the operations have also included feral cat trapping and a pet cat and dog spay and neuter clinic. Like rats, these animals also threatened the unique biodiversity of the atoll, and the trapping turned up a surprise for the PCS team. “The cat traps did catch two Micronesian Megapode, and both birds were released unharmed”, said Anu.

This is just the start for work on Kayangel. PCS will continue the bait station and cat trapping operations until complete, and will monitoring biological changes for the next year at least. Community members have also voluntarily taken on aspects of the biosecurity plan, such as inspecting incoming boats. Furthermore, additional conservation benefits have been realized through this project, including agreement by Kayangel’s leaders and community to nominate marine and terrestrial sites to the Palau Protected Areas Network, designate a new terrestrial protected area, and conduct island-wide management planning. A planning team has already submitted funding proposals to the National Government as part of its Protected Areas Network application.

"As a sizeable, inhabited, and remote Atoll, supporting threatened wildlife these characteristics presented many technical and logistical challenges to the removal of rodents and cats", said Steve Cranwell - Programme Manager BirdLife International Pacific Secretariat. "PCS are to be congratulated in their commitment to such a complex operation from which a tremendous amount has and will continue to be learned. With BirdLife Partners in New Caledonia, French Polynesia, Fiji, and the Cook Islands all working on island restoration projects sharing, these lessons are a valuable contribution in improving opportunities for eradication success and the resulting benefits".

Click here to subscribe to The BirdLife Pacific Quarterly E-Newsletter.

This project was made possible through funding from the United Kingdom Darwin Initiative, Critical Ecosystem Partnership Fund, Aage V. Jensen Foundation and Micronesia Conservation Trust, and through technical and financial (in-kind) partnerships with the Kayangel State Government and Traditional Leaders, Kayangel Community, Ngardmau State Government, Koror State Animal Shelter, Helen Reef Project, Palau Animal Welfare Society, USDA National Wildlife Research Center, Pacific Invasives Initiative, Pacific Invasives Learning Network, BirdLife International, and Palau Conservation Society. CEPF is a joint initiative of Conservation International, l'Agence Française de Développement, the Global Environment Facility, the Government of Japan, the John D. and Catherine T. MacArthur Foundation, and the World Bank.

Pacific Cook Islands Invasive Alien Species

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Milestone Celebrations 60Th Birthday Napkins (16 Count)

Style #BB103241
Our Price: $2.43 MSRP: $4.85

Don't let a little ketchup splatter ruin your day. Our 12.75" Milestone Celebrations 60th Birthday Napkins will save you from stains and spills, their square rainbow-striped bodies full of confetti and birthday wishes. Perfect with any of the Milestone 60th party supplies here.

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DEFINITION: An Open Source relational database management system (RDBMS) that uses Structured Query Language (SQL).
MySQL White Papers (View All Report Types)
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Decision Maker's Cheat Sheet for Today's Hot Databases
sponsored by NuoDB Inc
WHITE PAPER: This quick guide compares the capabilities of three of today's top database management systems – MySQL, MongoDB and NuoDB.
Posted: 03 Mar 2014 | Published: 31 Dec 2013

NuoDB Inc

Mitigate Slow MySQL Queries and Accelerate Overall Query Performance to Gain New Competitive Platform Capabilities
sponsored by Akiban
WHITE PAPER: Read this white paper to learn about a new relational database from Akiban, a unified document and relational architecture that accelerates MySQL applications to ensure consistent and compelling performance for end users with no change to code, architecture or infrastructure.
Posted: 30 May 2012 | Published: 30 May 2012

Postgres Plus 8.4 vs. MySQL 5.5: Feature Comparison and Commentary
sponsored by EnterpriseDB Corporation
WHITE PAPER: This paper compares Postgres Plus Standard Server and Postgres Plus Advanced Server 8.4 against MySQL 5.5. The comparison is broken down into a number of sections with a short commentary following each section. Read on to learn how the Postgres Plus 8.4 stacks up against MySQL 5.5 on all the above topics and learn which one comes out on top.
Posted: 01 Sep 2010 | Published: 01 Sep 2010

EnterpriseDB Corporation

PostgreSQL vs. MySQL: A Comparison of Enterprise Suitability
sponsored by EnterpriseDB Corporation
WHITE PAPER: This paper presents a comparison between PostgreSQL and MySQL. Fundamental and more sophisticated features and performance that characterize enterprise capable databases are contrasted between PostgreSQL and MySQL. This comparison can be very useful to those who have little or no experience when it comes to MySQL in deployment.
Posted: 27 Aug 2009 | Published: 27 Aug 2009

EnterpriseDB Corporation

CIO Guide: The Strategic Value of MySQL
sponsored by Sun Microsystems, Inc.
WHITE PAPER: This white paper examines a model whereby CIOs can reduce their database costs significantly by adopting a heterogeneous database architecture and implement MySQL for a large part of their business critical and operational applications.
Posted: 05 Aug 2009 | Published: 01 Mar 2009

Sun Microsystems, Inc.

A Guide to Lower Database TCO
sponsored by Sun Microsystems, Inc.
WHITE PAPER: In this white paper, you'll learn how organizations such as Sabre Holdings, Cox Communications, and NASA have improved database reliability, performance and TCO using MySQL. You'll also see how these techniques can apply in your organization.
Posted: 24 Jul 2009 | Published: 07 May 2008

Sun Microsystems, Inc.

PostgreSQL vs. MySQL - A Comparison of Enterprise Stability
sponsored by EnterpriseDB Corporation
WHITE PAPER: Many IT professionals generally recognize that PostgreSQL is better suited for enterprise database responsibilities than MySQL. In this paper you'll find an in-depth feature & performance comparison between the two.
Posted: 23 Jun 2009 | Published: 01 Jun 2009

EnterpriseDB Corporation

Practical Open Source Data Integration Case Studies & Implementation Examples Volume 2
sponsored by Talend
WHITE PAPER: This document presents a few selected case studies, illustrating real-life implementations of open source data integration and its associated benefits.
Posted: 11 Feb 2009 | Published: 11 Feb 2009

Top 5 Considerations While Setting up Your MySQL Backup
sponsored by Zmanda Inc.
WHITE PAPER: A well thought through backup plan and configuration will go a long way to ensure that you can recover your database - when a system or user error deletes important data stored in MySQL - without impacting your business.
Posted: 09 Jul 2008 | Published: 08 Jul 2008

Zmanda Inc.
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Online Transaction Processing Software

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High-Performance Cloud Computing with In-Memory OLTP
sponsored by Rackspace
WHITE PAPER: In this white paper, discover how you can implement high-performing, fast-paced OLTP by using the cloud.
Posted: 11 May 2015 | Published: 11 May 2015

Mixed All-Flash Array Delivers Safer High Performance
sponsored by Dell, Inc.
WHITE PAPER: This white paper showcases a sale-out all-flash storage array that redefines the economics of enterprise storage by deploying a single platform for block and file with built-in efficiency, resiliency and intelligence to optimize your IT budget.
Posted: 17 Dec 2013 | Published: 08 Aug 2013

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Accelerating Oracle with Flash
sponsored by Kaminario
WHITE PAPER: Access this white paper to learn how Oracle paired with an all-flash array can reduce storage space and increase processing speed.
Posted: 04 Mar 2015 | Published: 31 Oct 2013

A Low Cost Data Warehouse Using SQL Server 2008
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WHITE PAPER: This paper outlines different considerations for separating decision support systems (DSS) from Transaction Processing (OLTP) environments and touches upon technical procedures for achieving the same, as well as examines data warehouse solutions, different storage topologies, storage interface optimizations and much more.
Posted: 08 Oct 2010 | Published: 29 Jul 2009

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Take BI to the Next Level with In-Memory Technology
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WHITE PAPER: SAP in-memory computing is putting the "r" back in "real-time" computing by bringing together online transaction processing (OLTP) applications and online analytical processing (OLAP) applications at a lower total cost. Get an in-depth look at how this technology will impact business.
Posted: 21 Apr 2012 | Published: 31 Mar 2011

Make the Right Database Investment
sponsored by Sybase, an SAP company
WHITE PAPER: This paper compares the TCO of Oracle11g and Sybase ASE 15 databases, and demonstrates Sybase as the clear winner. Read this paper to learn why enterprises choose Sybase ASE on Linux for mission-critical applications that demand lightning-fast performance.
Posted: 19 Jun 2009 | Published: 19 Jun 2009

Sybase, an SAP company

BI is in the Details: How Columnar Technology Leverages the Latent Value in SQL Databases
sponsored by Vertica Systems
WHITE PAPER: This paper will discuss how Vertica enhances the capabilities of analytical work through the implementation of different architecture for relational database-based analytical work. By simply rotating the orientation of the database from rows to columns, dramatic improvements in load and query speed, scalability and cost effectiveness are achieved.
Posted: 29 Aug 2011 | Published: 01 Sep 2009

Vertica Systems

Backup and Recovery Performance and Best Practices for Exadata Cell and the Oracle Exadata Database Machine
sponsored by Oracle Corporation
WHITE PAPER: One of the key operational aspects of deploying a Sun Oracle Database Machine is to ensure that database backups are performed and restoration of the Oracle Database is possible if disaster strikes. This paper describes the best practices for setting up the optimal backup and recovery strategy to protect your mission-critical data.
Posted: 07 Oct 2010 | Published: 30 Jun 2010

Oracle Corporation

Customers Achieve Extreme Performance at Lowest Cost with Oracle Exadata Database Machine
sponsored by Oracle Corporation UK Ltd
WHITE PAPER: In the days of big data, organizations are seeking larger databases that can offer faster response time to increasingly complex queries. Access this reference booklet for a sampling of case studies focusing on the real business results that organizations in a variety of industries worldwide have achieved by implementing Oracle Exadata.
Posted: 15 Jul 2013 | Published: 31 May 2011

Oracle Corporation UK Ltd

Channel Sales Management; Beyond CRM
sponsored by BLUEROADS Corporation
WHITE PAPER: Channel sales management can be one of the most pressing issues for companies today. The channel represents enormous opportunities, but its management has historically been fraught with inefficiencies. IDC offers a new point of view.
Posted: 24 Oct 2006 | Published: 24 Oct 2006

BLUEROADS Corporation
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Transport news

Outcry over tariffs, not tolls says lawyer

28 Nov 2012 06:43
The public outcry against the tolling of Gauteng's highways was related to the tariffs, the High Court in Pretoria heard on Tuesday (27 November).
"I think we should make it clear that the public outcry is not because of tolls but the tariffs," Vincent Maleka, senior council for the transport department said.

He said the South African National Roads Agency Limited's (Sanral) notice of intention to toll roads had received the transport minister's approval.

Maleka was responding to submissions by Opposition to Urban Tolling Alliance (Outa) lawyer Mike Maritz made in court on Monday (26 November). Maritz had argued that the implementation of tolls was unlawful and that Sanral's initial notice to toll roads in Gauteng was "sterile" and "misleading".

Maleka added that the transport minister consulted the public and considered the cost of e-tolling when he approved the upgrade to Gauteng's highways.

On Tuesday morning, David Unterhalter, for Sanral, responded to Outa's submissions by saying the allegation that the initial notice of the intention to toll roads in Gauteng was "sterile" and "misleading", was inconsistent.

He argued that Sanral did what was required by law, engaged with the public, and that the Gauteng Freeway Improvement Project was not part of the 2010 Soccer World Cup.

Unterhalter told the court it had been reported in the media that there would be upgrades to major roads in Gauteng.

"Sanral was not going to simply toll existing roads. Roads were going to be improved."

Unterhalter argued that all relevant civil society organisations representing Gauteng motorists knew about e-tolling and the user-pay principle when the project started in 2008, but did nothing until the tariffs were announced in 2011.

He said e-tolling was inevitable because the upgrades to Gauteng's highways had been completed, at a huge risk to Sanral. He questioned why it took Outa and other organisations so long to act, saying they waited until the last gantry was put up before they said anything.

Unterhalter argued the application to have e-tolls scratched should be dismissed, saying it was a "conspiracy theory".

"The application has no foundation and it should simply be dismissed."

He said Outa changed its submissions after the Constitutional Court in September overturned an interim order, granted by the High Court in Pretoria, which had put a hold to the Gauteng e-tolling project, pending the current review.

"What the applicant [Outa] tried to do is to solicit information that the cost of tolling is very high. This is a matter of concern," he added.

"At the moment their case contradicts itself."

The Constitutional Court found the High Court in Pretoria had not considered the separation of powers between the high court and the executive.

On April 28, the high court granted the interdict to the Outa, ruling that a full review needed to be carried out before electronic tolling could be implemented. The interdict prevented Sanral from levying or collecting e-tolls.

Sanral and the Treasury had said the delays in implementing e-tolls had prevented the payment of R21bn incurred in building gantries.

Wearing red shirts, members of the Congress of SA Trade Unions watched proceedings from the public gallery. The trade union federation is opposed to the implementation of e-tolls.

Unterhalter said Outa should pay legal costs if the application failed.

Final arguments would be heard on Wednesday (28 November).

Source: Sapa via I-Net Bridge

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Anderson Silva: ‘Weidman Rematch For My Legacy’

December 19, 2013 10:57 am 35 Comments
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“Sometimes you have good days for working, sometimes you have bad days for working,” said Silva. “My last fight was a bad day.”

“I watch the last fight. And I see my technique and I talk to my friends and my coach and I don’t change too much. I train hard my mental because my mental was bad.”

“This is very important for me. For my family, my coach, for my legacy, this is very important.”

“So the people, maybe in five or 10 years, the people say ‘my gosh, this guy changed the sport. For five years this guy fight for the best fight for the people.’ In Brazil, I have a program for kids and I see the kids, ‘oh my gosh, one day I go to fight because you changed my life.’ This is more important to me, to change kids’ lives, than to beat Chris Weidman.”

Long reigning, pound-for-pound king, Anderson Silva, recently held a media day at his Muay Thai college in Southern California.

During his Q&A session he touched on the importance of next week’s UFC 168 main event rematch against new champ, Chris Weidman.

Can Silva do it? Will he be able to redeem himself against the New York based champion?

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Old 09-27-2008, 01:51 PM   #30 (permalink)
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Now I'm in trouble -

I can't connect via bluetooth - it keeps asking for the security code and it won't accept the one I had set it up with.

I was somehow able to connect via the cable, I started the update of the OS and 10 minutes in it disconnected.

I have no way of connecting the phone to the computer. I also can't use the phone, there's a white screen with a box with a "no" circle going through it and the number 507 underneath.

Other than giving up and going to get an iphone, any ideas?
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Old 11-26-2009, 05:29 PM   #10 (permalink)
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FYI.... I just got the prompt to update. And I got what you got. The only profile showing for me was Outlook, I selected it, etc. I now have "profile options" in "options" and I can select always use the Outlook profile, or prompt for profile.

I won't swear I never saw the "choose profile" step in the installation before. I could have been on autopilot, just clicking through. But I definitely didn't have the "profile options" menu item before. I looked when we were working on this the other day, and it wasn't there.

Also, interesting, the update shows as v. 5.0.1, which is what I have, so this update is an update to 5.0.1. I wonder about the posts where people are saying they get an update prompt but they already updated.

And I notice DM now shows device connected and active device, instead of just device connected as before. This was definitely an update and not a resinstallation.
- Ira

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Thread: BES 5 interface
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Old 12-05-2012, 09:02 AM   #3 (permalink)
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Default Re: BES 5 interface

Web management is the future

BAS is much better than it was when BES 5 ame out 4 years ago. I was not looking forward to it. there are a few things I do miss but I can get around it.
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Old 02-03-2008, 02:51 PM   #2 (permalink)
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Originally Posted by crucifixion View Post

I have a Pearl 8100 on Tmo

My Internet browser used to work perfect, but for whatever reason, outta no where it doesn't work.

If I got to, it will say http error 400 bad request. then when I click on more details, it will say connection refused

This happens for any website address

But its funny because if I go to HOME, I can click on there and access it with no problem

So right now I can't access anything that is not on the home page
If you have not already done so try a battery pull and then try it again. If still no go start here:

What are the TCP and APN settings? -

Good Luck!

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Rhonda Walker Talks Career Success and Mentoring Program

Rhonda sees her profession as community service.

From Huffington Post

TV Anchor Rhonda Walker found her calling 11 years ago. She started her journey in television as a traffic reporter honing her skills; she realized soon after that she wanted to do something for the community in education.

Walker decided to start a mentoring program called the “Rhonda Walker Foundation’s Girls Into Women.”

The program lasted for five years and works on career and self development in young women. At the advice of her father, she started the mentoring program so that young people could see what they could become.

Read more at Huffington Post


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Paul Ryan: 'Stereotypes And Misconceptions To Win Elections'

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Rep. Paul Ryan

It's easy to attack and demagogue those who don't have a voice.

It's easy to blame others when you fail to provide true leadership. And it's easy to reinforce stereotypes and misconceptions to win elections, or to win over your party's base. That is precisely what Republican Rep. Paul Ryan did last week when he made despicable comments regarding inner cities, and inner-city men in particular.

Discussing a "tailspin of culture" of "men not working and just generations of men not even thinking about working or learning the value of work," Ryan insulted generations of men and women who rise early every morning for an honest day's work, or to look for work. Whether or not Ryan believes his own deplorable statements doesn't matter; it's the fact that he feels the need to utter them that should make us all very worried.

2014 is another pivotal year. The midterm elections -- the outcome of which will determine what direction the nation heads -- are around the corner. Do we want to keep progressing forward, or do we want to revert back to a time when culture wars and scapegoating were the norm?

Based on his own comments and actions, it would appear that Ryan would like to do the latter. Referencing Charles Murray, co-author of The Bell Curve, a book that called blacks inferior and was widely viewed as racist, Ryan knew exactly what he was doing. Using code words like "inner-city" and "culture," he sent subliminal messages to an audience he was clearly trying to cater to. How can the House Budget Committee Chairman not be held accountable for such despicable words? He knew better, or rather, he knew exactly what he was doing.

For the rest of the article please see the Huffingtonpost

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Is Spidey's Broadway home looking to get out of the superhero biz?

Is the Foxwoods Theater in New York City—where Spider-Man: Turn Off the Dark is scheduled to open next month—already looking for other shows? The answer might be yes.

According to the New York Times, three Broadway producers said that the theater's management is "sending signals" that the $65 million production might not have a very long stay at the Foxwoods. All three producers, who currently have productions running or are planning new ones, told the Times that they were contacted within the last two weeks by Erich Jungwirth, the new general manager of the Foxwoods, who called around to introduce himself and ask the producers to keep the theater in mind for future productions.

Now these kinds of introductory calls are apparently standard operating procedure for a new theater manager, but the producers said they were surprised that Jungwirth was already asking about future shows with Spider-Man not even running yet.

Jungwirth, when contacted by the Times, said in a statement, "I can confirm that I have met with people in the industry to introduce myself as the new GM of the Foxwoods Theater. It is the custom in our industry for a new GM to both introduce themselves in the community and to see if there are any shows coming up that may be able to play in our venue. ... As for Spider-Man: Turn Off the Dark, we are incredibly positive about the prospects and are optimistic that the show is going to have a fantastic run at the Foxwoods Theater for many years to come."

A spokesman for the show itself said, "We are looking forward to Spider-Man being at the Foxwoods Theater for years to come."

The cast and crew of Spider-Man go back to work tonight after having Monday off. The show had its first preview on Sunday night, with reports indicating that the long-delayed and expensive production's many stunts and special effects failed to work properly, while its score and script were also said to be lacking. The show is scheduled to open on Jan. 11, and a spokesperson told the Hollywood Reporter that previews "will continue as planned."

Related Stories

That Spidey musical swings onto Broadway in 2010

The musical version of the Marvel Comics superhero story debuts next year.

So how much did Spidey musical's director just win in her lawsuit? Trent Moore

Though all the injuries and delays finally gave way to a Broadway smash, a lingering lawsuit from the former Spider-Man: Turn off the Dark director has hung over the play like a gooey ball of webbing—but not anymore.

Read the original WTF ending of the Spider-Man Broadway musical Matthew Jackson

Spider-Man: Turn Off the Dark is raking in the dough on Broadway these days, but things didn't always look so rosy for the show. Director Julie Taymor's time on the musical was plagued by injuries, bad previews and story problems—and that didn't even include the insane ending she originally wrote for Turn Off the Dark that never made it to the stage.


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Bliss & Fire Network Bliss & Fire Network

...Igniting the world with the unfailing love of God in Jesus Christ!

About Us | Bliss & Fire Network

Who We Are

... a prophetic network.

Bliss & Fire was launched in 2005 as a worldwide prophetic ministry network and been steadily adding more network members each year. The network holds monthly non-denominational conferences on different continents that are designed to encourage men and women of God to "Walk in the prophetic fire of the Holy Spirit and take their rightful place as the sons and daughters of God on the Earth."

The men and women who attend the monthly ministry conferences, go back to their various ministries and Churches newly empowered by the power of the Holy Spirit to do things they have not been able to do before.

The prophetic network's visionary and founder, Pastor Wales is a Teacher, Mentor, Prophet, Evangelist and an entrepreneur. He along with other participating ministers, equips, mentors, and encourages men and women from all walks of life with the Word of God. This is to ensure the visions and dreams that God has deposited on the inside of them will become a reality! God is looking for the few committed men and women who are brave enough to: carry His fire, accept the call of God upon their lives, and to walk in their Son-ship as fire brand Christians.

Network Benefits:

Why you should be part of it!

Network Chapters:

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Our Vision:

God has commissioned us to take His Divine Presence to the people of the World, by the power of His Holy Spirit. In Soul winning, we are reaching out to men and women and bring them out of darkness so that they can enjoy the glorious light and liberty of the Son of God; Building them by helping them to develop their human spirit through the Word of God and to understand the principles and teaching of the new covenant in the blood of Jesus Christ.

We teach and demonstrate the love of God, thus raise people who will do the same hence, giving dignity, value and meaning to the lives of people. To this end, we are organizing programs, seminars, conferences and crusades in carrying out these set aims and objectives.

Our Mission:

  • To ignites the World through the Love of Christ Jesus.
  • To instill the reality of divine life, this life in its attributes includes Righteousness, Prosperity, Success, Abundance, Victory, Divine Health and to facilitate fresh, innovative, and effective opportunities to strengthen the church through the power of the Holy Spirit in prophetic matter and introduce Jesus Christ as Lord and Savior to people of the World.


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Diablo III Beta Video Stream # 1

Written by Medievaldragon on . Posted in Diablo 3 News, Diablo III Beta

Here is a Diablo III internal beta video stream from nvsammy. I took some screenshot from his livestream showing the shrines, stash, and other perks such as blacksmith recipes you can bring to the blacksmither to learn how to make armor and weapons. Some spoilers likely, so skip the dialogues if that ain’t your thing.

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When The Broom Sweeps The Floor By Itself, I’ll Actually Be Impressed

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Tumblr Embraces Twitter On iPhone (Adds Extra Features)

After updating their iPhone app in order to be compatible with iOS 4, it looks as if Tumblr has added an extra feature that will please tweetaholics.

Reblog posts to any of your blogs using the native editor. Even peek at the original post if you need to. […]

Click-through links and uploading via URL are now supported. […] ‘Send to Twitter’ switch now respects your individual blog settings. (Official Tumblr Blog)

While the native reblogging feature was long overdue (as defaulting to the web version in between was annoying), the selective “tweet your post” feature should make it easier to share specific posts to the twitterverse.

The click through link feature is also another welcoming development, as it will make it easier for Tumblrers to credit (via link) artwork discovered online and posted to their blogs.

Tumblr has not hinted on whether they will expand this feature to Facebook as well (instead of the default “share all or none” mode), although it’s good to see the company pack more features into their mobile apps.

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Wednesday, December 2, 2009

Hitting up the New Haven Cupcake Truck, At Long Last

Cupcake Truck New Haven

When you live in New York you become accustomed to lines. Lines for good pizza, lines for your favorite brunch place, and yes, lines for food trucks. Now where I'm from in New Haven, people wait in line for two things. Pizza and pastries--usually pastries of the Italian variety in anticipation of various feast days. Well, now you can add cupcakes to that list...

I've been wanting to try the New Haven Cupcake Truck for ages. They typically are on the road from Monday through Friday when I'm typically in NYC. A family event brought me home to CT a little early just a few Fridays ago and I knew that I would be seeking out the Cupcake Truck.

As soon as my dad picked me up from the train, I revealed the plan. Pick up cupcakes. Pick up Thai food. Right before I left for New Haven I checked out the Cupcake Truck's twitter. They were planning to be outside the Study Hotel on Chapel Street from 4:00pm until they ran out. But when we arrived the truck was no where to be found. Sadness. So Dad and I drove around in search of this Thai place I read about online. A few laps around downtown lead us back to Chapel Street where we decided to check out Thai Taste. As we passed the Study Hotel we noticed that a long line had formed. Could it be?

Cupcake Truck New Haven

YES! The Cupcake Truck was pulling into position. After about 15 minutes of waiting in line, it was my turn. At the Cupcake Truck you get to choose your cupcake and frosting for $2 and then you can add toppings like rainbow and chocolate sprinkles for .25. Premium toppings like cocoa nibs go for .50 or more. My first choice was easy--red velvet with vanilla frosting. I was intrigued by their pumpkin cupcake, but torn between their maple cream cheese frosting and their chocolate frosting. Cupcake Truck co-owners, Todd and Marsha Rowe suggested that I needed to try it with half and half. Brilliant!

Cupcake Truck New Haven

The cupcakes were delicious. Moist and sweet but not too sweet. I shared bites with the fam and they were a hit all around. Certifiably delicious. Now I have to figure out how to get myself back to New Haven when the Cupcake Truck is out and about...

Cupcake Truck New Haven

The Cupcake Truck
Follow them via their blog and/or twitter

Blondie said...

The 2 cupcakes choco and vanila looks so cute!
you made me craving for one right now :)

Katherine said...

Yay, it's nice to see New Haven finally represented! I saw the New Haven Cupcake Truck covered in CT Magazine a few months ago (along with that adorable couple in your last photograph) and had been meaning to try it. I just might give it a shot now! Also, have you tried the food carts over on Church St., next to Yale-New Haven Hospital?

Brownie said...

@Katherine: I haven't had a chance to check out much of the cart scene in New Haven. Why did all these awesome carts arrive after I moved to NY? :) I have had the lamb tacos from the Tijuana Taco Truck ( Any other trucks I should seek out?

Katherine said...

One of my most recent finds is the tres leches cake at the arepas cart, which is one of the carts farthest from the hospital. I don't know if they still have it since I haven't been there in a while (they kept slices of it in a cooler last summer), but it was a great, really authentic tres leches cake. There is also a Chinese cart with really good General Tso's chicken (if you're into greasy Chinese food) across the street from the plaza (with the pigeons), which doesn't really have a name. It has a sign that says something along the lines of "Healthy, Not Oily". But beware, there is an imposter cart with mediocre Chinese food and a similar sign on the same side of the street as the plaza. Those are just my recommendations. I don't know how these carts would compare with the ones in Manhattan, but they're cheap and tasty.

Truck Rental said...

Looks yummy and right in place :) hope to meet a truck of this kind someday..

Dream Cupcakes CT said...

If you liked Cupcake Truck you must definately visit us at 194 Buckland Hills Drive, Manchester, Connecticut! We serve the best cupcakes (hehe :)) in Connecticut! You can check out our site too


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Carter, Not Dubai, for Spring At Last
Photo: Coglianese Photos
Spring At Last will run next in the Carter Handicap (gr. I) at Aqueduct April 5.
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Connections of Spring At Last, a convincing winner of the Feb. 2 Donn Handicap (gr. I), have decided to bypass the $6-million Dubai World Cup (UAE-I) March 29 and aim instead for the $300,000 Carter Handicap (gr. I) at Aqueduct April 5.

Trainer Doug O’Neill confirmed the decision March 6, saying the main consideration was to give Spring At Last a little more time between races.

“We’re very honored by the invitation to the Dubai World Cup,” he said. “It’s just the timing — we think it’s a little too much at this point.”

Spring At Last has never won at the Dubai World Cup distance of 2,000 meters (about 1 ¼ miles), but O’Neill did not cite as factors the distance or the fact 2007 Horse of the Year Curlin already is waiting in Dubai with a victory at Nad Al Sheba Racecourse under his girth.

However, he did note that Spring At Last underwent surgery for a bone chip in an ankle last year that sidelined the 5-year-old son of Silver Deputyfor about nine months following his impressive win in the Godolphin Mile (UAE-II) at Nad Al Sheba.

“We just thought after winning the grade I race in Florida that we would focus on giving him plenty of time afterward,” O’Neill said. “Maybe if the Dubai race was in another month or so, it would be a lot more tempting. Right now, it would just be too much to ask.”

Spring At Last worked a half-mile at Hollywood Park in :50.20 the last week of February, at which time O’Neill said the Dubai World Cup was still the next objective for the earner of $1,137,650. Nothing has gone awry since then, he said;  the horse is “doing fantastic.”

Bred in Kentucky by WinStar Farm, Spring At Last races for the farm in partnership with J. Paul Reddam. WinStar will be represented in the Dubai World Cup by homebred San Antonio Handicap (gr. II) winner Well Armed, a son of Tiznow  who is trained by Eoin Harty.

Reddam and O’Neill could have another opportunity to compete in Dubai this year with grade II winner Notional. O’Neill said they are hoping to receive an invitation to race in the $5-million Dubai Duty Free (UAE-I), a 1,777-meter event on the turf.

“He’s a fantastic colt — we’re just so excited about him. We’d love to try him on the turf over there,” he said of the 4-year-old son of In Excess. “He’s doing well, came out of his prep in great shape, and is ready to go if we get the invitation.”

Notional finished third by a neck in the 6 1/2-furlong Daytona Handicap on the Santa Anita Park grass Feb. 17. Last year, he was a strong classic candidate, winning the San Rafael (gr. II) and Risen Star (gr. III) Stakes before finishing second to Scat Daddy in the Florida Derby (gr. I).

A fracture of his left front cannon bone kept him away from the races for almost 11 months, with the Daytona marking his return to competition.

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Evans Dispersal Horses Shine at Keeneland

Mike Ryan, acting as agent on behalf of an unnamed client, purchased a Medaglia d'Oro   colt for $470,000, the highest priced colt so far during the Sept. 13 session of the Keeneland September yearling sale.

The colt, consigned by Lane’s End, agent for the complete dispersal of the Estate of Edward P. Evan’s Spring Hill Farm, was bred in Virginia by Evans. The colt is a son of the grade II winning Pleasant Tap mare Tap Dance, a half sister to stakes winner Grand Prayer, the dam of grade I winner Malibu Prayer.

The next horse in the ring after the Medaglia d’Oro colt was a Speightstown   filly. Consigned by Lane’s End on behalf of the Evans estate, the filly was purchased by Susan Casner for $450,000. Casner is the wife of Bill Casner, formerly a partner in WinStar Farm.

Also bred in Virginia by Evans, the filly was produced from the stakes-placed Pleasant Tap mare Tap Gold.

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