text:
Civilization and its discontents

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Hogarth Press, 1949 - Civilization - 144 pages
257 Reviews

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NOTE: I consider Sigmund Freud a writer of fiction. - Goodreads
Hard to read and disturbing theories. - Goodreads
Plus, Freud is an impeccable writer:) - Goodreads
Freud is so hard to read... - Goodreads
This is short and easy to read and worth the time. - Goodreads

Review: Civilization and Its Discontents

User Review  - Katie Dusold-Harkreader - Goodreads

Excellent book. Lots of technical language; not written for the layman. Also, several of the ideas discussed in this book are dated and have been disproven since its writing. Read full review

Review: Civilization and Its Discontents

User Review  - Nico Battersby - Goodreads

Psychology lectures are famous for dismissing Freud. "Oh" they'll scoff, "Freud was obsessed with sex! Don't even waste your time with him". A strange way to recognize the father of psychoanalysis ... Read full review

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Mega Scary Stories for Sleep-Overs

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Price Stern Sloan, 1996 - Juvenile Fiction - 126 pages
1 Review
Get ready for creepier creeps, scarier ghouls, spookier ghosts and more things that go bump in the night! The latest in the popular series is the scariest one yet. This book includes 11 original stories and fiendishly scary illustrations that will take the sleep out of any sleep-over!

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its a nice book.. n really very scary..
must read..

The Corpse of Mr Porter
Death Sight
Fountain of Horror

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About the author (1996)

Don L. Wulffson is the author of more than forty books, including Point Blank, The Kid Who Invented the Popsicle, Future Fright, and The Upside-Down Ship. He lives in Northridge, California.

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Category › Education

Guest Post: Riding with Kids in Cornelius

This guest post is written by Russell Crispin, BTA Advocacy Intern.  “Not everybody can come on the bike ride,” I said with regret when a young […]

El Programa Hispano

Last year, The Bicycle Transportation Alliance led bikes rides with 63 high school students from El Programa Hispano in East Portland and Troutdale. These rides were […]

BTA and Bikes 4 Humanity Spring 2015 Bike Drive

image (4)

The Bicycle Transportation Alliance Education team partnered with Bikes 4 Humanity on June 6 and 7 to donate 40 bikes, helmets, sets of lights, bells, and U-locks […]

Safe Routes to School: Beach Elementary is ready to roll!

Thank You City Council for supporting Safe Routes to School!

Kids at Beach Elementary School rode with us as part of their final lesson in the Safe Routes for Kids curriculum on Friday (6/5). During the […]

Walk+Bike Challenge Event Recap: Liberty Elementary

W+B Liberty

On Friday, May 22nd, Liberty Elementary in Tillamook, Oregon decided to ramp up their Walk+Bike Challenge by hosting their own Walk+Bike event. The event was a […]

Walk+Bike Challenge in Three Easy Steps!

W+B abc

Easy as ABC, 123! Register! It’s that simple. Sign your school up for the Challenge and download the coordinator packet for great tips and resources. Order incentives! All […]

Five Reasons to Track for the Walk+Bike Challenge

W+B Tracking

Tomorrow kicks off Walk+Bike Challenge month! Have you registered your school? The Walk + Bike Challenge is a friendly competition aimed at encouraging more kids and families […]

Walk+Bike Challenge Champion: Patrick Deegan

Meet Patrick Deegan, Walk+Bike Coordinator at Edison Elementary for the last two years. Patrick first became involved in Walk+Bike in 2012 when he noticed that there […]

It’s Electric: The Benefits of E-bikes

Did you know that the fastest growing sector of the cycling industry worldwide is e-bikes? Electric bikes are taking off in Europe. In Belgium and the Netherlands, where […]

Walk+Bike Challenge Champion: Holly McRae

Holly McRae

You can be a Walk+Bike Challenge champion like Holly! There are many different ways to get involved and support the Walk+Bike Challenge. You can become a Challenge Coordinator […]

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text:
Comment 9 for bug 730488

Yvon TANGUY (vono22) wrote :

Yes I think, it's maybe not the first time it happen, I don't remember.

Maybe it is the MAD driver which does not do things well. Erase files with their own, it's not a good way to do. But it's like that, and I cannot change it. One thing can be done really easily I guess, it's to warn the user of this issue.
If you are aware of it, you can takes actions before it brakes.


text:
Will these floating amoebas be the cityscape of year 2108?

At the TEDxCity2.0 talk in San Francisco earlier this month, Craig Scott of IwamotoScott Architecture presented these mindboggling renderings of giant, hovering daisies. Unlike the sky-suspended, donut-shaped pedestrian plaza that will supposedly grace the future firmament in Manhattan, these structures are built to harvest fog for fresh water, according to Architizer. It's all part of the San Francisco of year 2108, or what could be if built environments weren't so resistant to change, says Scott. IwamotoScott proposed a coevolved urban landscape for the future, a city in which major structures support each other rather than thrive or struggle independently. The crux of the plan's symbiotic city is the sprawling, underground Hydro-Net, which traps rain water—the streets will be porous, see—and distributes power and fuel. The city will rely solely on geothermic energy and hydrogen-producing algae and fog, and the environment will be built around those needs, starting with fog-collecting air amoebas, apparently.

HN-fog-flower-600x450.jpegRendering via Architizer

"The proposition for us was to provoke, to think about the city, which is very resistant to change in its built environment, and to think that there are ways of coexisting and coevolving new architectures," says Scott. Well, it's certainly provocative, perhaps even more so than other wacky renderings to have emerged recently, like the apartments built into an abandoned bridge, the world's first floating town, those man-made island domes, and that sparkling "Earth City" utopia.

HN-coast-600x450.jpegRendering via Architizer

· Blade Runner Meets Flower Power In IwamotoScott's City Of The Future [Architizer]
· All Architectural Craziness Coverage [Curbed National]

Copyright © 2012 Curbed National


text:
Cam4 Free Tokens Adder V3!

Cam4 Free

Cam4 is a site dedicated to amateur exhibitionnists… and voyeurs. The main concept is simple, amateurs film themselves in live with their cam and voyeurs come to watch them. In the same time it’s possible to talk using the chat available with every cam. The chat allows voyeurs to send comments and requests. In order to motivate all of the participants there’s a system based on tokens which allows exhibitionnists to be financialy rewarded for their shows. This site is really huge, usually there’s more than 1000 cams at the same time.

Cam4 Tokens Adder

CAM4 Free Tokens Adder finally released! This program uses some exploits in to add free tokens to your account.

Cam4 Tokens Adder

Free CAM4 Tokens Adder / Generator 2013 INSTRUCTIONS:
1. Download and install latest .NET framework
2. Create CAM4 account.
3. Log in to your account.
4. Download and run CAM4 Tokens Adder.
5. Choose how many credits you want and what browser do you use.
*WARNING* Do not add more than 10.000 tokens/24h. It may make your account closed!
6. Add Tokens!
7. Spend them on anyone you want!
also you can watch Youtube video proof or this one below:

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100% Clean: Scanned by VirusTotal.Com


text:
Don’t buy a Kindle to read maths or computer science books

The volume rocker of the Amazon Kindle 2
The volume rocker of the Amazon Kindle 2 (Photo credit: Wikipedia)

In the last twenty-four hours I have been forced to completely reassess my view of the Kindle.

I have been reading a book (I won’t say what as I want to make the comments below anonymous) on a Kindle (the device, not an application – see below), and was resigned to the usual second class Kindle editing – the odd missing paragraph, the loss of a non-roman letter or symbol here or there, when I came to a chapter which was essentially unreadable because it relied on (for example) the difference between P and \bar P but was unable to render \bar P , merely displaying P .

I was so frustrated and annoyed – how could any publisher allow their book to be published in this form when a whole chapter was rendered into (literally) nonsense – that I emailed a senior editor of the publisher to complain.

To be fair to them, they replied quickly and passed on my complaint to a senior colleague:

This is a problem with the way the Kindle displays mathematics and it is an ongoing problem that we are trying to solve with Amazon and other hand-held device makers … I suspect you will be due a refund from Amazon.

The reply does the publisher a lot of credit, and more or less restored my faith in them. But it also carries a very simple message – don’t buy a Kindle to read technical books.

I have since discovered that one Kindle app – on Mac OSX – renders the book perfectly, while another – on Android – is just as poor as the Kindle itself.

Why are Amazon selling books that are broken like this?

In the meantime I suggest sticking to hard copies when it comes to technical works.

Update: Not sure why I thought the Mac OSX app worked – it’s just as broken as the Kindle itself.

2 thoughts on “Don’t buy a Kindle to read maths or computer science books

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text:
Dubailand: Destination Dubai

William Goetzmann; Irina Tarsis

Format: Hardcopy Black & White
Also Available In: English PDF
List Price:  $6.93 Source: Harvard Business School
Publication Date:  Jul 14, 2006 Product #: 207005-HCB-ENG
Discipline:  Business & Government Relations Length:  28 p,  English Hardcopy Black & White
Revision Date:  May 24, 2006
  • Description

Under the leadership of the al-Maktoum family, Dubai, a member of the United Arab Emirates, invested heavily in its infrastructure to reduce national dependence on oil and gas reserves. As an established international destination for shipping, business initiatives, and tourism in the Middle East, Dubai embarked on a new megascale project: to construct the world's largest amusement park, called Dubailand. Examines various aspects of Dubai's background, world real estate and tourism trends, and environmental and political conditions of the region to support a discussion of this ambitious project's feasibility.

Learning objective:

To expose students to William Riley's Law of Retail Gravitation and a gravity model, which provide a framework for estimating retail sales at a given location based on two factors: population of a district and the distance to the retail location. Also, to consider such factors as cultural biases and political instability.

Subjects Covered:

Cross cultural relations; Forecasting; International business; Politics

  • Geographic: United Arab Emirates
  • Industry: Amusement & theme parks
  • Industry: Real estate, rental & leasing
  • Industry: Tourism services
  • Event Year Begin: 2004
  • Event Year End: 2005


text:
Habitat for Humanity International in South Africa

Arthur I Segel; Nicolas P. Retsinas; Nelson Hioe

Format: Hardcopy Black & White
Also Available In: English PDF
List Price:  $6.93 Source: Harvard Business School
Publication Date:  Nov 29, 2006 Product #: 207016-HCB-ENG
Discipline:  Finance Length:  22 p,  English Hardcopy Black & White
Revision Date:  Jan 19, 2007
  • Description

In March 2006, Larry English, Director of Program Design and Innovation for Habitat for Humanity International Africa and the Middle East, was reflecting on a large development project in Durbin that had stalled. Notwithstanding global attention led by former President Jimmy Carter, the local capacity to carry out the project was limited. English wondered whether partnerships with private, for-profit real estate companies were plausible, and whether they could be carried out without undermining the mission of Habitat to focus on the very poor.

Learning objective:

To illustrate how partnerships can facilitate real estate investments in emerging markets.

Subjects Covered:

Emerging markets; Social enterprise

  • Geographic: Africa
  • Industry: Real estate, rental & leasing
  • Industry: Residential construction
  • Event Year Begin: 2006
  • Event Year End: 2006


text:
Inside Intel Inside

Youngme Moon; Christina Darwall

Format: Hardcopy Black & White
Also Available In: English PDF Spanish PDF Spanish Hardcopy Black & White
List Price:  $6.93 Source: Harvard Business School
Publication Date:  Jun 5, 2002 Product #: 502083-HCB-ENG
Discipline:  Marketing Length:  24 p,  English Hardcopy Black & White
Revision Date:  Oct 12, 2005
  • Description

In early 2002, Pamela Pollace, vice president and director of Intel's worldwide marketing operations, is debating whether the company should extend its "Intel Inside" branding campaign to non-PC product categories, such as cell phones and PDAs. The "Intel Inside" campaign has been one of the most successful branding campaigns in history. However, the campaign is more than ten years old, and growth in the PC market appears to be stagnating. In contrast, sales of portable digital devices--such as PDAs and cell phones--appear to be growing at a healthy rate. Pollace is debating whether the "Intel Inside" campaign will work in these other product categories, even though Intel doesn't dominate these other markets like it does the PC market, and it isn't clear that consumers will associate Intel with these other markets.

Learning objective:

Allows students to examine the logic and implications of an ingredient branding strategy. Facilitates a discussion of some fundamental questions about branding, such as: Why do companies build brands? What does a brand buy you? What are the necessary and sufficient conditions for a successful branding campaign? How extensible are brands?

Subjects Covered:

Advertising; Advertising campaigns; Barriers to entry; Branding; Brands; CAM; Cause marketing; Community development; Consumers; Direct marketing; Execution; Expansion; Multibranding; Revenue growth; Sales closing; Strategic positioning; Sustainable competitive advantage

  • Geographic: California
  • Industry: Semiconductors
  • Company Employee Count: 83,000
  • Company Revenue: $26 billion revenues
  • Event Year Begin: 2002
  • Event Year End: 2002


text:
Wreck This Journal: Good Thoughts

While most pages in Wreck This Journal are about seeing the world with a positive eye, one page in particular is set aside for recording good thoughts.  This was easily one of my favorite pages as I have a “thing” for collecting quotations in journals, sticky notes, or anywhere else I can scribble a line of wisdom.

Grandma approached this page with her usual brand of quirkiness and independence. Not only did she record good thoughts, but she scribbled in anything that made her happy.

Grandma’s page of good thoughts.

Her handwriting is a little tough to read, so I’ll translate:

Grandma always loved a beautiful car. She pasted in a Mercedes Benz because it was one of her favorite brands, although she loved a good Jaguar, too. I remember how she’d walk right up to one in a parking lot and look in the windows. She never owned either a Mercedes or a Jag, but she never stopped dreaming.

Quote: Kindness is like jelly – you always get some on yourself.

Quote: God is good.

Quote: It’s not the amount of years in your life. It’s the amount of life in your years.

Quote: I feel good. I feel great. I feel wonderful. – Bob Wiley. I have to laugh at this because it comes from an all time favorite movie in our family, “What About Bob?” Get us all in a room and we could probably quote that movie from start to finish. Even towards the end when Grandma had forgotten so much, she still knew  “What About Bob?”

Candy bars.

$ – This makes me laugh, too. Grandma loved money, but not like you’d think. Sure, she like the idea of nice things, but she also loved finding a penny on the ground. The woman found pennies, nickels, dimes, and quarters wherever she went.

As for my page, I pulled some of my favorite quotes out of my main quotation journal. Then, I added some color, because color always makes me happy.

My page of good thoughts.

I should probably add one more thing to my page of good thoughts – memories of Grandma.

– – –

c.b.w. 2014

12 thoughts on “Wreck This Journal: Good Thoughts

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Algeria hostage crisis

Associated Press
Two British hostages Peter, left, and Alan, right, (no family name available), are seen after being released, in a street of Ain Amenas, near the gas plant where they have been kidnapped by Islamic militants, Saturday, Jan. 19, 2013. Algeria's special forces stormed the natural gas complex in the middle of the Sahara desert in a final assault Saturday, killing 11 militants, but not before they in turn killed seven hostages, the state news agency reported.(AP Photo/Anis Belghoul)

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Algerian forces are scouring the Sahara desert for five foreigners missing since Islamist militants attacked a remote natural gas plant, an official said Jan. 22.

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CDF Presents Patient-Focused Celiac Drug Development Survey Data to FDA

On May 11, 2015, the Food and Drug Administration (FDA) will conduct a public meeting on Functional GI Disorders Patient-Focused Drug Development. Celiac Disease Foundation was requested by the FDA to provide commentary about the impact of celiac disease on patients’ daily lives, the types of treatment benefit that matter most to patients, and patients’ […]

Proud Sponsors of Celiac Disease Foundation


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Browsing All posts tagged under »Shenandoah River«

“Grandpap”, General Ewell, cousin George, and a bigger story

August 24, 2013 by

Not long ago, while perusing the papers of Confederate civilians in Fold3, I dropped in the names of some relatives in the Valley, just to see what I might find. For starters, I found that my third great grandfather, William M. Dorraugh, was of help to Gen. Richard S. Ewell. It was a small thing, […]

Off the “warpath”, and on the river

July 17, 2011 by

This morning being the way it is today (almost early September-like), I find my mind in other places than working toward the First Battle of Manassas/Bull Run, or focusing on some aspect of war, whether that be the Civil War or the First World War. Rather, I’m in the mindset, today, of the Valley before […]

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Bill Hill: One Ocean

7 minutes, 45 seconds

Right click “Save as…”

Bill Hill has always been a fan favorite on Channel 9. In fact, his early interviews helped us crystallize the original (now referred to as OldSchool since we have other great methodologies in place on 9) Channel 9 Method of human-focused, unrehearsed real conversations with people. We haven't forgotten about you, Bill!

Bill left the company last year to pursue other interests, one of which being the making of music and music videos. Since Bill is a Niner, we decided to post one of his timely music videos, One Ocean, on Channel 9. With the oil spill in the Gulf of Mexico, the overfishing of the oceans, the pollution of the seas, Bill has a message for us all and it comes in the form of original music plus live action video (also known as a Music Video...). Thanks for sharing, Bill. It's great to see (and hear) you again. You'll always be welcome on Channel 9. We miss you, man!

Enjoy! This is Bill Hill 5.0!! Smiley

Follow the Discussion

  • Thanks for posting this, Charles! I think this is actually Bill Hill 5.0 Smiley

    John Leighton Beezer, who plays the two great guitar solos, is a former Microsoft Program Manager on the old eBook team...

    The music is a track from my new CD, "Dancing With The Dragon", which will be out in the next few weeks. It was all written about living and surfing here on Kauai. "One Ocean" was written while paddling out to my surf break - The Dragon. I started thinking "We call oceans 'Atlantic', 'Pacific' and so on. But they're really all joined. There's only one ocean. The dolphins don't care what we call parts of it. They go wherever they want". I meet dolphins and green sea turtles out there almost every day.

    I'd finished recording and mastering all the tracks. Then a few weeks later, the Gulf Oil Disaster happened. I started thinking:"How would I be feeling right now, if I knew there was a huge oil well blowout 30 miles from Hanalei Bay, and we were just waiting for the oil to come ashore? It would be the end of everything I love. The dolphins and turtles would be dead. You couldn't go in the ocean. You wouldn't even want to walk on the beach."

    And that's when I realized I had to do something. I decided to use the track "One Ocean" to help focus attention on the need to protect the ocean. So I started filming. I bought a $270 GoPro HDSurf camera and attached it to my standup paddleboard. I used the same camera to film the turtles, dolphins, and for the underwater shots. And I started learning video production techniques, scripting and storyboarding. Remember, I was a writer and editor for almost 20 years before I go involved with software.

    I've offered free use of the song and/or video to any organization working to protect and conserve the ocean.

  • CharlesCharles Welcome Change

    Bill Hill 5.0 it is!! Changed in the description text.

    Hope you're well, Bill. Great to see you on 9 again.

  • figuerresfiguerres ???

    wow bill i will for sure watch this later as i have liked the old interviews and i live in tampa FL and part of my teen age years i lived just outside of Santa Barbara CA and had to deal with tar on the beach and oil in the waves back then ....

    we really need to get off Oil as fast as we can, but what to replace it as we use it in so many ways...

  • Take it one step at a time. First; replace gas cars with electric vehicles such as the Nissan Leaf, then replace the power company with solar shingles, and finally; replace natural oil with synthetic oil and  synthetic plastic

  • Bent Rasmussenexoteric stuck in a loop, for a while

    That looks fun! Thanks for that lovely postcard. Smiley

  • ivan_ivan_ g

    THE safest and THE cleanest way for now is NUCLEAR Energy. It is also the cheapest and the fastest way to get US energy needs met.

  • YAAAY, Niners! I posted this on YouTube and had 500 hits in a week. Channel9 already has more than twice as many - and it's been up just a few hours! Thanks so much for your interest and support!

    In reply to figuerres: I've actually been thinking that alternative energy might end up being Bill Hill 6.0 Smiley

    We installed solar hot water here, then we installed a 24-panel PV system, with battery backup. We can be off the grid if we want, and there's more than enough power most days to keep an electric car fully charged for all the miles we do. It wasn't cheap but it has proved it's absolutely feasible to say, "I'm DONE WITH OIL!" Plastics, of course also need to be tackled as IDWMaster says above.

    Next: We haven't eaten anything but raw food for the past six months - all of it organic, most of it bought locally at the farmers' market. I wouldn't have believed it but I enjoy my food more than ever and don't miss cooked food at all. And don't give me the protein fallacy, because I've been surfing almost every day for more than a year.

    Our range is propane. But the only thing we were using it for was boiling water for tea. So we bought an electric kettle and now we're off propane too.

    I'm waiting for the right vehicle and we'll go electric.

    Now, we live on Kauai where's there's lots of sun. But our neighbor in Carnation, WA heats his home all year round - even when there's snow on the ground - using only geothermal. He dug out a pond, ran pipe at the bottom.

    In the 1980s and 1990s everyone wanted to be a software engineer. That's where the growth was. I believe in the coming decades the growth will be - has to be - green energy. Smart software has a role to play there too.

    I believe President Obama needs to announce the 2010 equivalent of President John F. Kennedy's "Put a man on the Moon by the end of the decade" mission. Something like: "We will enable every American to drive 400 miles a day and heat and run their home without any use of fossil fuels by 2020". And then he needs to put in place a budget, similar to NASA's during that mission. I'd gladly see my tax dollars used for that.

    Anyway, I'm doing a lot of research, wondering if I really want to set up a company, and considering what it might do. But I have to do something. There's Only One Ocean.

    If you have friends who're not Niners, they can watch the video on YouTube at: http://www.youtube.com/watch?v=FTL76IrFJvg

  • rhmrhm

    Hi Bill, great mellow tunes.  Sounds like you're really enoying yourself outside the old ratrace. Looking at the video, I'm trying to imagine you doing that back in the North Sea - also an oil production centre. Think you'd need to wear more than just the shorts? Smiley

  • I used to surf in the North Sea. Water temperature 38F, air temperature 28F, run across the snow on the beach to get in the water, wind 30mph, windchill infinite. I think I prefer it here Smiley

  • figuerresfiguerres ???

    Ivan : in it's current form nuclear has a heck of a lot of problems i think.... things like the waste and making sure a reactor is not a new chernoble etc....

    also i see the current state of reactors as beeing glorified "Steam Engines" a lot of stuff just wrong with the whole picture.

    lets work on this before we build more of them.

  • ivan_ivan_ g

    The plastic can be biodegradable. First invented by George Washington Carver, boy, almost a century ago. It is widely used. In Russia for example they sell milk in plastic bags which degrade under sunlight or in soil in just 1 year, while regular plastics takes almost 500 years to degrade.

    Thus garbage produced by average american family will last longer  than nuclear waste from nuclear power plant. Latest generation nuclear plants can recylce waste very efficently with average degration rate of only 60 years.

    Convert to nuclear then electric cars will produce less CO2. For now, since most of the east cost is powered by coal, electric cars will actually produce more CO2 than gasoline cars. Plus coal is very dirty and kills orders of magnitude people more a year than nuclear power plants/waste.

  • ivan_ivan_ g

    Absolutely not true.

    There are no new generation nuclear reactors in US at all. There have been only 65 direct deaths for 30 years from nuclear plants. While hundreds of people a year die in coal mines and now this oil spill, plus indirectly all the lung cancer people get from pollution. Just look at US energy map and see how it is powered.

    New generation nuclear plants, used in France for example, are very efficient and produce less waste than average american family does.

    Now there is a joint effort between US DOE and Russian Ministry of Nuclear Energy on a new generation nuclear power plant which has almost 0 waste, becasue most of it just get recycled.

    So at the end nuclear is cheap, fast, clean and safe. You can put "...est" and the end of those words and it will be true.

  • We should avoid nuclear. My father worked on the construction of Hunterston A nuclear power station in Scotland. It was a first-generation Magnox gas-cooled reactor, now being decommissioned. Its replacement was the Hunterston B station with two later-generation Magnox gas-cooled reactors. Work started on those in 1967, and in  2006, British Energy found cracks in one of the two reactors, with almost a fifth of the 500 boiler tubes experiencing defects. Power Technology in August 2007 reported a sharp decline in output, with the high operating temperatures having led to wear and tear.
    I am old enough to remember when nuclear power was being advocated as the Brave New Future. It would be clean, there were no real hazards, no-one mentioned nuclear waste, and these plants were supposed to produce electricity so cheaply it would eventually become almost free. That certainly didn't happen. It was a myth.

    "Only 65 direct deaths" is sophistry, and doesn't account for the much greater long-term effects of accidents like Chernobyl, where "Health officials have predicted that over the next 70 years there will be a 2% increase in cancer rates in much of the population" exposed to radiation. Late in 1995, the World Health Organisation (WHO) linked nearly 700 cases of thyroid cancer among children and adolescents to the Chernobyl disaster. Birth defects - some horrendous - have been documented.

    The "new generation nuclear plants" are being brought to us in a collaboration between the people who gave us Three Mile Island and the people who gave us Chernobyl. And that's supposed to inspire confidence?

  • Some unordered thoughts:

    • the planet runs out of oil in, what, 150 years?  Coal and natural gas will also be depleted in a time frame close to that of oil.
    • Once the use of fossil fuels ends, the earth should recover from the damage done. No?
    • It is the huge and growing population of the world which is what endangers us and the planet.
    • Every  year, something like 3 million more people immigrate into the US. Those additional people both increase the American use of oil, they also decrease the amount of open space in the country. The less open space, the less the capacity to capture energy from the Sun.
    • I could go on, speculating about what comes of society and the planet when 10 billion people run out of the natural resources which enable a huge population to support itself. But I will not. I don't want to sound overly hysterical.
    • Holy cow, man. Think of what the future holds for us!
  • I agree. Over-population is the #1 issue, the cause of all the others. Tribal conflicts in Africa (like Rwanda, for instance) aren't REALLY about tribal differences. Those are really just convenient lines along which to separate people into THEM and US. They're about too many people competing for too little (usable) land.

    The ocean has been overfished because too many people eat too many fish. We drill in dangerous places because too many people burn too much oil. I could go on, and on, and on. But it's the ultimate cause of all the problems.

    Jared Diamond's book, "Collapse" is a must-read. Read the history of ChacoCanyon, for instance. Then do some research on Los Angeles, - where its water comes from, where its power comes from, how the entire lifestyle of the city is built on cheap gasoline, etc.

    If we don't find a balance ourselves, nature will impose one. Widespread famine, or a nice plague with a 95% mortality rate, or...

    And we don't have anything like 150 years.

    I don't mean to be depressing. There are things that individuals can do. Like opting for a more sustainable lifestyle. Or - like some couples I know - opting not to have children.

    You can't fix the world. But you can change yourself.

  • Elmerelmer I'm on my very last life.

    USA Military budget for 2010 (including contingencies) is: $664 billion

    You could do an awful lot of R&D into energy solutions for part of that.

  • Elmerelmer I'm on my very last life.

    Oil supplies are unlikely to last anything like 150 years, but that's almost beside the point.

    The falling rate of discovery, the inflated figures of OPEC and the rampantly increasing demand from China and India, means that it will very soon become far too expensive to use as a means of powering a motor vehicle.

  • figuerresfiguerres ???

    Bill also not to be depressing but to just add to the list look at Easter Island and what people did there....

    I wonder if at some point some local looked around and said something like "Man we are really up a creek!"

    with all our tech have we really learned much ?  we are still doing a lot of crazy stuff...

    sometimes I think of the work of J.R.R. Tolkien

    there is a passage in Lord Of The Rings where Gandalf talks about wisdom and that if you break a thing to try and learn about it then you have already failed.

    "Smashing Atoms" is I think what he was really talking about indirectly.

    but you can apply that idea to anything .... you do not learn very much from destorying a thing, other than how to destory it.

    this by the way is not a stand against studying accidents etc.... just a  look at the deeper meaning of what it is to learn and understand things.

    and the need to gain not just "Knowlege" but also "Wisdom" and they are not the same.

  • Easter Island is one of the case studies in Diamond's book, "Collapse" - which I believe should be a core part of every school curriculum.

    It's easy to be seduced by technology to the point where you ignore everything that isn't "technological progress". The key in this - as in everything else in life - is balance. From the reverse perspective, it's easy to decry technology as a "death force" and ignore its benefits. Have you read "Zen and the Art of Motorcycle Maintenance"?

    Tolkien - as he says very categorically - despised allegory in all its forms. So he was not writing specifically about "Smashing Atoms" or about the evils of trench warfare in the First World War, as has been suggested. He left it to his readers to draw their own parallels. Yours is a valid one.

    "Knowledge" and "Wisdom" are definitely not the same. In my mind, for instance, there's no real difference between torturing prisoners to obtain information about an enemy's plans, and torturing animals to gain information about human diseases. We can only justify the latter because most of us are what I call "Human Racists"; i.e. we believe humans are the Master Race and so can do anything we want to "sub-human" forms of life - eat them, experiment on them, exterminate them for the benefit of humans. Exactly the reasoning Hitler and the Nazis used to justify the Holocaust. First convince people of the "sub-humanity" of Jews, Gypsies, homosexuals etc. Then you can do whatever you want.

  • MSDN or C9 obviously has a block on the "N" word which is the shortened form for Hitler's National Socialist "Democratic" Party, even when it's correct usage and not used an an insult.

  • figuerresfiguerres ???

    True I and many many other keep "reading in to" his works, hard sometimes not to do that i think due to the amazing way he wrote.

    Zen and MM - no sorry have not.

    As a Teen I did read Ram Dass if you know who he is/was.

    He really gave me a lot of ideas.

    also I read a *LOT* of Sci Fi .... Robert A. Heinlein is a huge favorite of mine

    I have the Unabriged hardbound that his wife got published after his death of "Stranger In A Strange Land"

    he had an interesting code for how humans should live, can't recall the name but there is a guy who lived thru WWII who talks about our Ultimate responcibility to take ownership of our actions and our in-actions and not try to pass them off with bull like "I was tempted" or "Peer pressure" You did it. END. that's it.  stand up and take your punishment or reward as needed.

    Be Here Now!

  • Ram Dass I know, although haven't read much. I went a different route. Took up yoga in 1971, the book I had recommended vegetarianism and no alcohol if you wanted to make real progress. I haven't touched either since. It was clearly not necessary to kill animals or fish for food or to stay healthy - so why do it?  I have read "Stranger" many times.

  • Elmerelmer I'm on my very last life.

    Actually, although it makes for a terrific fable, Jarred Diamond's assertions are quite tenuous and based on a lot of assumptions. It's commonly agreed by archaeologists that introduction of disease from Europeans was primarily responsible for the demise of the native Easter Island inhabitants, rather than the environmental impact of cutting down all the trees or any social traditions.

  • figuerresfiguerres ???

    While I am sure that the "Last Straw" may have been  that I think the years of no outside contact and the lack of food had a role to play....

    not to mention the way the records do show that folks hid in caves ... I think it must have been fairly nasty there before any european came there.

    so when the whites came there were how many ? 2 or 3 thousand ?

    so what about the estimates of 10 to 15 thousand as the prior numbers....  *SOMETHING* was going on that had zero to do with whites.

  • First, I don't agree with everything Diamond says. However, he makes it clear that he doesn't support single-cause explanations in any of these societal collapses. Secondly, I read "Collapse" in the context of having read the excellent "Guns, Germs and Steel" several times - in which he makes clear the devastation created by European diseases on "native" cultures.

    However, quoting from "Collapse": "Even before Magellan became the first European to cross the Pacific in 1521, abundant evidence attests to massive human impacts on Easter: extinctions of all the land bird species, disappearance of porpoises and tuna from the diet, declines of forest tree pollen in Flenley's sedimentary cores before 1300, deforestation of the Poike Peninsula by around 1400, lack of radiocarbon-dated palm nuts after 1500, and so on". Significance of "disappearance of porpoises and tuna from the diet" is that there were no trees left large enough to build the bigger canoes necessary to venture out far enough from shore to take porpoises and tuna.

    There's no hard evidence of a European visit to Easter before Roggeeen's arrival in 1722. Diamond says, though, that the islanders nonchalant, unafraid and curious reaction to Roggeveen's ship suggest prior experience of Europeans.

    But that couldn't have happened before Magellan...

    The first specific mention of an epidemic on Easter is of smallpox, in 1836. Even Diamond doesn't believe that was the first epidemic, though.

    He believes climate change may also have played a role, as did Easter's isolation from volcanically active areas - which provide a source of soil renewal in airborne ash etc. It was a combinations of factors.

    Nothing is ever as simple as a single-cause explanation. But it sounds like you bought one. Did you really read Diamond's books?

  • CharlesCharles Welcome Change

    Bill's new album:
    http://www.songstonestudios.com/page3/page3.html" target="_blank">http://www.songstonestudios.com/page3/page3.html

  •  @Charles: Thanks, Charles!

  • @Jocuri Barbie: I agree

  • Duncan MackenzieDuncanma "yeah that's awful close, but that's not why I'm so hard done by"

    Opening these comments, as Bill's videos are getting viewed again

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Ping 75: IE9 Beta, Halo in History, Tokyo Game Show and SCRABBLE

18 minutes, 45 seconds

Right click “Save as…”

In addition to all the hot stories that you'll hear about on this episode of Ping, Paul and Laura FINALLY played that grudge match of Scrabble. Clearly, one of them cheated.

IE9 Beta rocks

Halo and classic literature?

Super Fun Happy Tokyo Game Show

Halo reach hits stores...BIG time

Follow the Discussion

  • martinminemartinmine I eat C# for breakfast

    Nice show, aggain!

    Congratz to the one that won Scrabble (I wasn't so sure when I saw the end lol).

    However, the IE9 looks great. But what about the unused space on the top of the window where the window title is supposed to be? I think you could shrink the window a bit more by using the space there. It could be a bit faster (Chrome still feels faster at loading pages =/), but its a good step, and I think you will regain lots of Firefox users on this release.

    Btw, are you still planning to do a behind the scenes show? Big Smile

    Good job!

    - Martin

  • CKurtCKurt while( ( !succeed=try() ) ) { }

    Loved loved loved the competition spirit between you two. Scrabble game was cool, antough the board seemed to get more empty sometimes Tongue Out

    Any chance the Imagine Cup can get an entry in next weeks show? I've got a post up about what to do to join. http://callemin.be/blog/?p=283 There must be some students watching the show right?

  • Where is the love for Windows Phone 7 Tools that were released last week?  That's some big news.  Maybe you can have someone from the Expression Blend Team on to talk about new features.

  • Shaggygi: Here is some love for the WP7 dev tools release. Cool

  • Thanks.  ScottGu is my hero!

  • Hmm, not convinced with the new website yet. For one it doesn't work in my Chrome browser (is this intentional?). Also its all a bit boring, clean and boxy for my liking. But thats just my opinion. I'm sure its all wonderful HTML, CSS and jQuery or whatever but essentially as a user I only care what it looks like. Maybe I'll get used to it. I only come here to watch PING anyhow. Big Smile

  • I want to play Halo with the hosts --  How are you planning to set that up?

    Good show and maybe next time Laura.

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 2012 Chapter of Excellence Recognition

We are pleased to share with you that the Philadelphia Chapter has been recognized once again as a Chapter of Excellence for advancing the profession by supporting the IIA's CIA Learning System.
A special note of thank you to Michael Brozzetti for his continued support and dedication to the program and to Villanova University for their generous support of facilities and resources.
As President for the 2012 Chapter year, Jerry Stussy will receive the certificate on behalf of the Chapter.


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Hipster doofus cuisine

May 21, 2009

pizzaWhat country has the greatest number of Domino pizza restaurants per capita?

That’s right! Iceland!

Oh, that wasn’t your guess? Well it wouldn’t have been mine either, but them’s the facts, at least according to a blogger on IcelandReview.com.

There are relatively few fast-food chains in Iceland, as we Americans know and love them, so we have noticed the Domino restaurants when we’ve been there, but only as an anomaly. Frankly, eating pizza never has occurred to us in Iceland and, even if it did, we wouldn’t have eaten Domino’s pizza there any more than we would eat it here.

The blogger, Aina Fuller, who is writing from Italy, not from Iceland, is musing over where she has had the best pizza of her life. I don’t have to think about that; it was the pizza my grandmother made, but there’s no point in dwelling on the unattainable. Fuller’s journal includes this observation:

But the glaring memory of the best in my mind, pulsing with Icelandic enthusiasm, is a mixed cheese pizza I had from a tiny restaurant in Saudárkrókur, where we shamelessly dipped bite after bite in home-made jam.
(For the foreign contingent, I know what you’re thinking. Pizza and jam might sound like trying to play a violin with a chicken feather, but don’t knock it ‘til you try it—and inevitably start doing it with a lot more strange combinations than pizza.)

Call me a stick-in-the-mud, but I won’t be trying that. I have to go along with Poppie, who told Cosmo Kramer that if you let people put anything they want – including cucumbers – on pizza, pretty soon you can no longer call it pizza.

Fuller mentioned salted cod as a favorite home-grown topping for Icelandic pizza, and she accurately pointed out that it isn’t so far afield of the anchovies Italians like. In fact, even though I normally don’t eat anchovies, I would inhale the pizzas my grandmother made with anchovies, garlic and wild mushrooms. I was surprised – maybe I should say relieved – that Fuller didn’t report that Icelanders like to top their pizzas with the rancid shark meat that is supposed to be such a delicacy up there.

Her blog is a lot of fun. It’s at this link:

waiter2One of the current brouhahas in San Francisco has to do with the annoying custom – or business practice – known as tipping. The city wants the restaurants in town to either provide health-care coverage for their employees or pay a fee to the city so that the employees can be covered by the universal health-care program. The restaurant owners are suing the city over that issue, but they have a counter proposal: A “tip credit” that would reduce the minumum wage paid to wait staff by the amount they earn in tips. Don’t you love it? The minumum wage in San Francisco is $9.79 an hour, by the way – a far cry from the federal requirement, but hardly the stuff of which fortunes are made.

tipping Tipping is one of my pet peeves. One of the reasons I like visiting Iceland is that tipping isn’t practiced there. Restaurants charge what they need to in order to pay the staff a living wage and still make a profit, and customers don’t follow up a meal by analyzing the quality of the service and the personality and repartee of the server.  Civilized people, those Icelanders – although, there is the whole whaling thing.

”Whaddya think? Fifteen percent? Well, he did bring more coffee. OK, what? Eighteen? Twenty?” Just the thing to encourage digestion.

Say it ain’t so!

March 15, 2009

totonnoThere was a near miss at Totonno’s pizza joint on Coney Island. A fire – apparently originating in the coal used to fire the oven – has shut the place down, but word is that it will reopen. This place has been in the same location and operated by the same family since 1924. It’s the only pizza place in the States that can make that claim. The family has a few more locations, but this is the original. We went there last year, just before Memorial Day. It’s a kick. You can’t park around there when the beach is busy – as it was that day – and when you finally do arrive, you have to wait outside until someone tells you to come in. It’s that small; it can accommodate only a few people at a time. The interior looks as it should. In other words, nothing has changed there since the first Coolidge administration. The pizza is out of this world, and I don’t say that about most pizza. It’s at least as important that this place has lasted all this time, that it’s a tourist attraction but also a mainstay of its neighborhood. A story like Totonno’s can be told more and more rarely in this country. Having grown up frequenting such institutions – Doc Pawlek’s drug store, Izzy Kaufman’s appliance store, Old Mr. Birkmeier’s delicatessen, Louie Grossi’s shoe repair shop, and my own grandfather’s grocery store, virtually all of which are long gone – I treasure such spots where I can find still find them. Va bene, Totonno!


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Intro to Civic Media

Intro to Civic Media: Understanding Daily Media Practice in Immigrant Communities

October just started, and it is that time of the semester when final project proposals are due. This is the case for my Introduction to Civic Media course, taught by CMS professor Sasha Costanza-Chock, where I am interested in understanding the daily media practice of immigrant communities in Boston.

For the past few years, my research has focused on media use among immigrant communities in the United States. Specifically, I have been looking at media activism and media practice in social movements for immigrants’ rights. Inspired by one of the earliest exercises in our Intro to Civic Media course about creating a model of digital inclusion, I am interested in understanding how immigrant communities, are already using media on a day-to-day basis. My previous research in this area has confirmed that there is no single “magic tool” that immigrant youth are using when communicating and networking with others. Instead, many media practitioners in the immigrants’ rights movement use a wide variety of media at their disposal, often entire media ecologies, in order to accomplish their goals. What’s more, for older generations, traditional media is still very central.

The Role of Technology and the Media in Whistleblowing

Whistleblowing has been the subject of recent controversies due to the rise of WikiLeaks and other whistleblowing websites. These websites mark a new form of whistleblowing only possible because of the Internet and computers as well as connected media partners worldwide. However, whistleblowing has relied on technology and media for a long time. Cryptome has accepted documents online for sixteen years. Daniel Ellsberg used a copier to copy the Pentagon Papers so he could give them to the New York Times. Muckrakers relied on the printing press to spread their findings.

Updated Project Proposal

Last week, we discussed our final project proposals and received feedback from one another. Although I feel that my project proposals are much more elementary than the others, I still have some positive feedback from a few of my ideas. I've essentially narrowed it down to two ideas: the humorous educational sketches and analyzing data visualization of various networks. I really like the first idea of creating humorous, yet informative shows on Youtube, mostly because it would take form of a pilot script rather than a paper. I realize that I would also have to write about my project no matter what, but executing the former idea seems a lot more enjoyable than the latter. Thus, I have decided to choose my final project to be about creating humorous educational sketches on Youtube.

Project proposal: an analysis of current commenting systems

With the growth of social media and various forms of participatory media, the line between the traditional content generators and the content consumers is fading. As a result, conversations and comments from consumers as well as their posts on social media are starting to become considered content itself.

As media moves towards utilizing conversations and comments to provide more content and context, it’s important to think about the definition of having a “good” conversation, the motives and incentives to get people to contribute to a good conversation, and also how to get a diverse set of commenters to avoid bias.

Hero Reports/Crónicas de Héroes

Project Status:

Hero Reports is a web based campaign of positive thinking established in New York during 2001.

Successfully wading through the social media onslaught

I am a science writer.

As such, I am one of many who claim membership in the scicomm* community, which has a vibrant internet presence. When I first decided to pursue a career in science writing, I spent a lot of time seeking out scicomm blogs, videos, Twitter feeds, etc. etc. etc. Suddenly, my daily media diet was far too rich. It's extremely difficult to keep tabs on what people are talking about, especially now that I am a full-time graduate student.

I suspect that I am not the only person who feels this way. That's why I would like to develop a discussion strainer (tentatively nicknamed 'Colander').

The application would work like this:
* You point Colander to a list on Twitter and define time parameters, e.g. the past day or week
* Colandar develops an internal word frequency list
* Colander presents (1) a list of the top 10-20 terms, (2) a graph showing the changing popularity of those terms over the given time period, and (3) any particularly popular comments on the topic

Easy as Pie: Building a Model of Digital Equality

Last week, the Intro to Civic Media class tackled the issue of digital inequality, first by looking at how the discourse around universal access has evolved over time. In the 90s, the dominant narrative was that of "the digital divide"—a binary classification that separates the haves from the have-nots. Since then, new research on the topic has helped broaden this framing into one of digital inequality, a more nuanced metric based on a number of important factors such as age, race, and socioeconomic status. As illustrated by the graphs shown in Eszter Hargittai's paper "The Digital Reproduction of Inequality" (shown below), information technologies have not successfully democratized American society; rather, they have exacerbated existing inequalities by "increasing the opportunities available to the already privileged while leading to the growing marginalization of the disadvantaged."

Digital Equality in York, Maine

Last class we discussed the crisis in journalism and digital inequality. Digital inequality is extremely important to discuss in the context of civic media because without wide access (in the broadest sense) to technology and the internet, civic media will at best provide a skewed perspective.

What does access mean? And what level of access is good enough? In class, we developed a few models of digital inclusion. In these, the most important considerations seemed to be infrastructure, technology literacy, and general climate towards digital engagement. These factors are broad and include many other concerns, each with its own degrees of inclusion. Still, they capture the general picture.

Digital (In)equality in the 52246

For Intro to Civic Media this week, we talked about and created a model for digital inequality. My group came up with a cute representation of digital inequality using a tree, where its roots represent components that add to digital equality, the leaves represent the fruit of digital equality, and falling fruit represents the idea that digital equality can fuel itself, just like a real ecosystem.

Before heading east to Cambridge, Massachusetts to come to MIT, I had never moved before — I hadn’t even moved out of the house I grew up in. I grew up in the fifth largest city in Iowa — Iowa City, a “metropolitan” college town with a population of just under 69,000.

Reflection: A Model of Digital Inclusion

Last class, we formed small groups to create a model of digital inclusion. My group tried to create a tool that would help us assess if and to what extent a community was digitally inclusive. The hope was that by creating such a tool, the components of a model to digital inclusion would naturally emerge. Ultimately, the tool would help us evaluate if residents of that place had access to Internet, hardware and software, educational resources, as well as digital ways to engage with the local government and learn about civic happenings (i.e. iphone apps, Internet sites, etc). We did not complete the tool, but tried to create an index or ranking system that would measure indicators or levels of digital inclusion. For example, the tool should measure the following:


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About the Climate Data Guide

The Climate Data Guide provides concise and reliable information on the strengths and limitations of the key observational data sets, tools and methods used to evaluate Earth system models and to understand the climate system.  Citable expert commentaries are authored by experienced data users and developers, enabling scientists to multiply the impacts of their work and the diverse user community to access and understand the essential data.

The Climate Data Guide was named an exemplary community resource by the 2012 U.S. National Academies' report, A National Strategy for Advancing Climate Modeling, and is an element of the strategic plan for NCAR's Climate and Global Dynamics Division. NCAR, the National Center for Atmospheric Research, is located in Boulder, Colorado and is widely respected as a leading institution in the atmospheric and related sciences.

A peer-reviewed overview paper describing the project is available.

Benefits of Being a Registered User of the Climate Data Guide
Benefits of being a registered user: Make comments on any data set page Upload your work and commentary to be featured on this site Receive notifications of new content  Keep the Climate Data Guide in existence.  Registrations help us to better understand our audience, enabling us to design the resource around user needs.  The user metrics are also extremely important for making the case for... more
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We encourage constructive comments and interaction. Please remember these guidelines: Users agree to UCAR's Terms of Use and Privacy Policy. For this site, the comments are visible without logging in, but only registered and logged in users may post comments and replies. You may post questions about the dataset, share your experiences using the dataset, provide links to relevant resources, or... more
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The Climate Data Guide is a community-authored resource. The Guide will be a living repository for the climate community’s collective wisdom and expertise on a broad array of observational datasets and their appropriate use in analyses and model evaluation. For more about the effort and to reference it in your work, please see the open-access article: Schneider, D. P., C. Deser, J. Fasullo, and K... more
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Sponsorship The Climate Data Guide is a project of the Climate Analysis Section (CAS), within the Climate and Global Dynamics Division (CGD) and Earth System Laboratory (NESL) at the National Center for Atmospheric Research (NCAR) in Boulder, Colorado, USA. The project is supported by a competitively selected grant (1048899) from the National Science Foundation (NSF). Principal Investigator Dr.... more
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Welcome to the new Climate Data Guide! The site has been completely redesigned (September, 2013). Here are some of the highlights and a note to existing users. Highlights Improved, simpler navigation and site organization. There are three main sections: Climate Data, Analysis Tools, and Model Evaluation.  Easier access to Search the site - from every page More readable page layouts so you can... more


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Soy Nut Study on Markers of Health

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2011 by University of California, Davis.
Recruitment status was  Recruiting
Information provided by (Responsible Party):
Francene Steinberg, University of California, Davis Identifier:
First received: July 23, 2010
Last updated: September 23, 2011
Last verified: September 2011

The investigators hope to learn about the effects of soy nuts on markers of health. When some people eat soy foods, their gut bacteria make equol. Equol is a soy metabolite (small molecule made during metabolism). The investigators will be testing blood samples to determine if markers of health are different for people who make equol versus people who do not make equol.

Condition Intervention
Metabolic Syndrome X
Other: Soy nuts
Other: Matched food

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effects of Soy on Metabolite Markers of Health

Resource links provided by NLM:

Further study details as provided by University of California, Davis:

Primary Outcome Measures:
  • Improve lipid profile [ Time Frame: After 4 week intervention ] [ Designated as safety issue: No ]
    Total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride level, apolipoproteinA1, apolipoproteinB100, apolipoproteinB100:apolipoproteinA1, urinary F2-isoprostane

  • Increase endothelial function [ Time Frame: After 4 week intervention ] [ Designated as safety issue: No ]
    Brachial artery flow mediated dilation, reactive hyperemia peripheral arterial tonometry, blood pressure, endothelin-1

  • Attenuate glycemic responses [ Time Frame: After 4 week intervention ] [ Designated as safety issue: No ]
    Fasting plasma glucose, insulin, fructosamine, homeostasis model assessment of insulin resistance

Secondary Outcome Measures:
  • Decrease inflammatory markers [ Time Frame: After 4 week intervention ] [ Designated as safety issue: No ]
    High sensitivity C reactive protein, vascular cell adhesion molecule-1, intercellular adhesion molecule-1

  • Follow anthropometrics for stable weight [ Time Frame: After 4 week intervention ] [ Designated as safety issue: No ]
    Weight, height, body mass index, waist circumference, hip circumference, waist:hip ratio

Estimated Enrollment: 36
Study Start Date: August 2010
Estimated Study Completion Date: September 2012
Estimated Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Sham Comparator: Matched food
Control food (matched for calories and macronutrients) per day for 4 weeks
Other: Matched food
Control food (matched for calories and macronutrients) per day for 4 weeks
Active Comparator: Soy nuts
Oil roasted soy nuts with 101 milligrams of soy isoflavones per day for 4 weeks
Other: Soy nuts
Oil roasted soy nuts with 101 milligrams of soy isoflavones per day for 4 weeks
Other Name: Genisoy

Detailed Description:

The objective of the study is to investigate the metabolomic response to consumption of soy protein containing polyphenolic phytochemicals (isoflavones). The aim of this pilot study is to demonstrate proof of concept and ability to detect metabolomic changes that are responsive to soy. This preliminary data will then be used to design future research projects.

Food phytochemicals such as the polyphenolic flavonoids from a wide variety of foods and beverages have been associated with cardiovascular protective effects in epidemiologic studies. Significant controversy exists in the literature regarding the efficacy and mechanisms for the cardiovascular protection of soy foods. The soy hypothesis for cardiovascular risk reduction has been focused mainly on the isoflavone content of soy, but uncertainty still exists regarding the bioactive component(s). In particular, consumption of soy protein foods has been associated with favorable cardiovascular disease (CVD) risk profiles in population based studies. Controlled clinical trials and meta-analyses however, have resulted in the conclusions that soy protein with associated isoflavones has only modest hypocholesterolemic effects in the range of 3-5% reduction in LDL-cholesterol. Additional cardioprotective effects have been demonstrated in clinical trials, promoting small but significant changes in vascular endothelial function and antioxidant protection. An important observation is that animal studies have shown reduction in atherosclerotic lesion size both with and without decreased blood lipid levels. These results taken together suggest that soy and soy phytochemicals can promote positive risk factors and outcomes by mechanisms in addition to, and other than lowering serum cholesterol levels. There is a need for greater understanding of the cellular and molecular mechanisms underlying the physiologic responses to isoflavones in the vascular compartment. Increasing evidence is emerging that biologically relevant concentrations of isoflavones may impact cell signaling processes in vascular and other tissues.

The large body of literature on human clinical trials of soy proteins and isoflavones has focused primarily on traditional lipid and lipoprotein parameters, biomarkers of CVD risk, and functional changes in endothelial function, platelet activation and total blood antioxidant capacity as described above. It is possible and likely that the effect of soy consumption on CVD risk is a net result of multiple subtle changes in metabolic pathways, vascular inflammatory responses and cell-signaling pathways which are not readily detected in healthy individuals. Since individuals with metabolic syndrome (MetS) present with many of the metabolic aberrations purported to be improved through soy food ingestion, these individuals may be an excellent study population in order to investigate the effects of a soy food intervention on metabolic markers of health. Equol is the end-product of daidzein biotransformation, and is produced only by some humans, resulting in a phenotypic characteristic in response to dietary soy. It is hypothesized by some researchers that the "equol producers" may have additional metabolic and phenotypic responses to soy which may help to explain some of the variances in the literature. Few investigators have examined this question in existing studies, with two reporting an association with outcomes and one no association. A recent study using microarray analysis of lymphocytes from postmenopausal women demonstrated differential gene expression in women who form equol compared to those who do not, suggesting that equol status may be an important modulator of responses to soy isoflavones. No studies have examined this question in a metabolomic investigation. This demonstrates a gap in the literature and provides an opportunity to contribute significant novel data using cutting-edge approaches.

Ages Eligible for Study:   21 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Postmenopausal women
  • Men ages 45 or above
  • Blood pressure greater than or equal to 130/85 mmHg but not greater than 160/100 and meeting an additional 2 of the remaining 4 Metabolic syndrome diagnostic criteria as defined by NCEP ATP III:

    1. Elevated waist circumference: men equal to or greater than 40 inches, women equal to or greater than 35 inches
    2. Reduced HDL cholesterol: men less than 40 mg/dL, women less than 50 mg/dL
    3. Fasting glucose greater than or equal to 100 mg/dL
    4. Fasting blood triglycerides greater than or equal to 150 mg/dL but less than 400 mg/dL
  • Weight of at least 110 pounds

Exclusion Criteria:

  • Smokers
  • Chronic disease, such as diabetes, cancer, renal disease, and blood disorders
  • History of intestinal disorders, which affect absorption or transit, such as ulcerative colitis or crohns disease
  • Allergy to soy
  • Antioxidant supplement usage
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01173380

Contact: Francene M Steinberg, PhD, RD 530.752.0160

United States, California
Ragle Human Nutrition Center Recruiting
Davis, California, United States, 95616
Contact: Francene M Steinberg, PhD, RD    530-752-0160
Principal Investigator: Francene M Steinberg, PhD, RD
Sponsors and Collaborators
University of California, Davis
Principal Investigator: Francene M Steinberg, PhD, RD UC Davis
  More Information

Responsible Party: Francene Steinberg, Professor, Chair, and Director Didactic Program in Dietetics, University of California, Davis Identifier: NCT01173380     History of Changes
Other Study ID Numbers: 200715715-4
Study First Received: July 23, 2010
Last Updated: September 23, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by University of California, Davis:
Metabolic syndrome
Endothelial function

Additional relevant MeSH terms:
Metabolic Syndrome X
Glucose Metabolism Disorders
Insulin Resistance
Metabolic Diseases processed this record on August 31, 2015


text:
Repeat Sexually Transmitted Infection (STI) Patients: Tailored Socio-Contextual Intervention to Reduce HIV Risk

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2012 by University of Wisconsin, Milwaukee.
Recruitment status was  Not yet recruiting
Information provided by (Responsible Party):
Lance Weinhardt, University of Wisconsin, Milwaukee Identifier:
First received: January 5, 2012
Last updated: January 13, 2012
Last verified: January 2012
No Study Results Posted on for this Study
  Study Status: This study is not yet open for participant recruitment.
  Estimated Study Completion Date: June 2015
  Estimated Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)


text:
4-Methylumbelliferone as a Treatment for Chronic HBV/HCV

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2006 by MTmedical Institute of Health.
Recruitment status was  Active, not recruiting
The University of Texas Health Science Center at San Antonio
BioMonde Preparations Limited
Information provided by:
MTmedical Institute of Health
ClinicalTrials.gov Identifier:
First received: June 30, 2005
Last updated: September 7, 2006
Last verified: April 2006

Open-label studies, anecdotal reports, and in vitro scientific research indicate that 4-methylumbelliferone (active ingredient of the dietary supplement Heparvit®) may prevent and reverse the symptoms and complications of chronic infection with hepatitis B virus (HBV)and hepatitis C virus (HCV). This effect has been observed among naïve patients as well as those who are non-responders to interferon, commonly used as first-line therapy for HBV and HCV. In order to scientifically address the efficacy of this 4-methylumbelliferone on chronic viral hepatitis, a randomized, placebo-controlled, blinded study is needed.

It is hypothesized that 4-methylumbelliferone may reduce the impact and aggressiveness of HBV and HCV upon the liver, thereby slowing the progression to potentially life threatening liver diseases such as cancer and cirrhosis. This is a preliminary study designed to determine any indications under controlled conditions that may warrant further detailed clinical studies.

Condition Intervention Phase
Chronic Hepatitis C
Chronic Hepatitis B
Drug: 4-Methylumbelliferone (Heparvit®)
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Evaluation of 4-Methylumbelliferone for Treatment of Chronic Hepatitis B (HBV) and Chronic Hepatitis C (HCV)

Resource links provided by NLM:

Further study details as provided by MTmedical Institute of Health:

Primary Outcome Measures:
  • Reduction of virus in blood to undetectable levels;
  • Normalization of serum ALT and AST.

Secondary Outcome Measures:
  • Reduced viral loads; Improvement of serum ALT and AST;
  • Improvement in general health status;
  • Improvement in serum marker of hepatic fibrosis;
  • Loss of HBeAg/seroconversion to HBeAb (for HBV patients).

Estimated Enrollment: 160
Study Start Date: September 2005
Estimated Study Completion Date: August 2007
  Hide Detailed Description

Detailed Description:

(i). Chronic hepatitis B

Chronicity of HBV following acute infection is strongly age-related; the majority (90%) of infants acquiring HBV perinatally go on to develop chronic infection, while most persons who acquire HBV later in life resolve their infection [ref 1]. Patients with chronic HBV have a 15-25% lifetime risk of liver cirrhosis and hepatic cancer. An estimated 5,000 people die each year from complications of chronic HBV infection (cirrhosis and hepatocellular carcinoma).

Three drugs have been approved by the Food and Drug Administration (FDA) for treatment of chronic HBV: interferon-α (IFN-α), lamivudine, and adefovir dipivoxil. Only one-third of chronic HBV patients develop a sustained response to IFN-α treatment, and adverse effects are common [ref 2]. Use of the newer orally-administered nucleoside analogues (lamivudine or adefovir dipivoxil) typically causes rapid initial clearance of virus and is associated with fewer adverse effects; however, seroconversion rates are low, and long-term therapy with lamivudine (required for sustained responses) frequently results in resistance [ref 2]. Adefovir dipivoxil has, so far, not shown the high rate of resistance observed with lamivudine, but it is expected that resistance will eventually develop [ref 3]. In summary, major problems with currently approved therapy of HBV include expense, toxicity, and development of resistance.

(ii). Chronic hepatitis C

Chronic viral hepatitis due to hepatitis C is an enormous medical problem, affecting approximately 170 million people worldwide (WHO) [ref 4]. In the U.S., an estimated 2.7 million people suffer from chronic HCV, with 10,000-12,000 deaths per year attributable to the disease (ref 5). Chronic HCV infections in the U.S. are usually acquired through injectable drug use, sexual contact, or receipt of contaminated blood products (before antibody screening was initiated in 1990). Most persons exposed to HCV (75%) develop asymptomatic chronic infection. Eventually, 15%-20% will die of cirrhosis and liver cancer without intervention [ref 4].

Only two drugs are licensed for treatment of chronic hepatitis C: IFN-α (standard or pegylated) and ribavirin. Sustained responses to IFN-α monotherapy have occurred in up to 35% of patients; higher responses can be observed with combination treatment (pegylated IFN-α and ribavirin) [ref 6,7]. Responses to combination therapy is closely linked with HCV genotype (types 2 and 3 most responsive). A significant number of patients relapse or do not respond to standard treatment, and retreatment is typically less effective than initial therapy [ref 8].

(iii). 4-methlyumbelliferone

Umbelliferones (7-hydroxycoumarins) [ref 9] are substances present in many species of plants, especially umbelliferae, fabaceae, and oleaceae, which include such common plants as manna ash, sweet woodruff, German chamomile, celery, parsley, and others. In nature, umbelliferones help protect plants from cellular damage, infestation, trauma, and infection. Their 7-hydroxycoumarin derivatives (4-methylumbelliferones) [ref 10] are used in liver therapy, as reagents, plant growth factors, sunscreens, choleretics, and spasmolytics. They are also used as light-protective agents, in the calibration of medical lasers, and in analytical chemistry for the quantitation of nitric acid.

Products containing 4-methylumbelliferone as their active substance have been available in the USA and Europe since 1990, as dietary supplements (under trade names Heparvit®, Heparmed®, DetoxPro®). These products are promoted as supporting liver function and improving detoxification. In many parts of Europe, products containing 4-methylumbelliferone are also available as drugs, and used as spasmolytics and choleretics [ref 11] (improving liver detoxification systems through increased bile production).

7-hydroxycoumarins are also natural metabolites in the body that play important roles in the metabolism of ethanol, chemotherapeutic drugs, acetaminophen, anabolic steroids, and other hepatotoxic drugs [ref 12]. Indeed, measurement of concentrations of 4-methylumbelliferyl glucuronide (a metabolic product of 4-methylumbelliferone) is a common assay for determining the level of toxicity of liver-toxic drugs [ref 13].

The broad potential medical benefits of 4-methylumbelliferone as a hepatoprotectant, anti-inflammatory agent, chemotherapeutic agent, and antiviral substance have been described [ref 13,14]. More recent studies indicate that 4-methylumbelliferone (and other 7-hydroxycoumarin derivatives) may be effective against Helicobacter pylori [ref 15], several types of cancer [ref 15-19], and Alzheimer’s disease [ref 20].

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Serum ALT at least 1.5x the upper limit of normal
  • For chronic HBV: Known positive serum HBeAg for at least 6 months; Presence of HBV DNA in serum
  • For chronic HCV: Presence of anti-HCV in serum within 6 months of enrollment; Positive serum HCV RNA (enrollment)
  • Written informed consent

Exclusion Criteria:

  • Treatment (within past 3 months) with interferon, ribavirin, lamivudine, entecavir, or adefovir dipivoxil
  • Current treatment with any drug or dietary supplement that could affect serum transaminase values (e.g., milk thistle)
  • Pregnancy or inability to practice contraception in patients capable of bearing or fathering children
  • Decompensated liver disease (as indicated by total bilirubin >4 mg/dL; albumin <3 g/dL; prolonged (>2 sec over control) prothrombin time; or history of bleeding esophageal varices, ascites or hepatic encephalopathy)
  • Active alcohol use, drug abuse, and/or psychiatric problems that, in the investigator's opinion, could interfere with participation in the study
  • Hepatitis D infection (for HBV-infected patients)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00225537

United States, Texas
University Health Center Downtown "Brady/Green", 527 North Leona,
San Antonio, Texas, United States, 78207
Sponsors and Collaborators
MTmedical Institute of Health
The University of Texas Health Science Center at San Antonio
BioMonde Preparations Limited
Principal Investigator: Charles T Leach, Prof. M.D. University of Texas Health Science Center : Department of Pediatrics
Principal Investigator: Anastacio M Hoyumpa, Prof. M.D. University of Texas Health Science Center : Medicine -Gastroenterolog
Study Director: Dubravko Pavlin, PhD University of Texas Health Science Center San Antonio
  More Information

1: Epidemiology and Prevention of Vaccine-Preventable Diseases, 7th ed, Eds W. Atkinson, C. Wolfe, 2003, Department of Health and Human Services, Centers for Disease Control and Prevention.
9: Penn State College of Medicine. Hershey, PA: 2004. Cited 2004 Dec 29. Faculty Research Expertise Database. Available from: http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D014468
10: Penn State College of Medicine. Hershey, PA: 2004. Cited 2004 Dec 29. Faculty Research Expertise Database. Available from: http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D006923
12: O’Kennedy R, Thornes RD, editors. Coumarins: Biology, Applications and Mode of Action. West Sussex, England: John Wiley & Sons; 1997. ISBN: 0-471-96997-4
20: Sun S, Kong LY, Zhang HQ, He SA, Niwa M. The asymmetric synthesis of linear dihydropyrano-coumarins for Alzheimer’s disease. Heterocycles 2004;63:271-82.

ClinicalTrials.gov Identifier: NCT00225537     History of Changes
Other Study ID Numbers: UTHSCSA 045-900-246
Study First Received: June 30, 2005
Last Updated: September 7, 2006
Health Authority: United States: Food and Drug Administration

Keywords provided by MTmedical Institute of Health:

Additional relevant MeSH terms:
Hepatitis A
Hepatitis B
Hepatitis B, Chronic
Hepatitis C
Hepatitis C, Chronic
Hepatitis, Chronic
DNA Virus Infections
Digestive System Diseases
Enterovirus Infections
Flaviviridae Infections
Hepadnaviridae Infections
Hepatitis, Viral, Human
Liver Diseases
Picornaviridae Infections
RNA Virus Infections
Virus Diseases

ClinicalTrials.gov processed this record on August 31, 2015


text:
Pulmonary Rehabilitation in Patients Before Lung Transplantation (LTx)

This study has been completed.
Information provided by (Responsible Party):
Klaus Kenn, Klinikum Berchtesgadener Land der Schön-Kliniken
ClinicalTrials.gov Identifier:
First received: July 27, 2009
Last updated: November 10, 2011
Last verified: November 2011

The purpose of this study is to study the effects of a complex pulmonary rehabilitation program on mobility measured by 6 minute walking distance (6MWD) and physical activity, measured via Dynaport and Actibelt Aktivitätsmonitor, dyspnoea (VAS), quality of life (HRQL (SF36, EuroQul)), anxiety and depression (HADS)and PaCO2-behavior under physical activity.

Condition Intervention
Respiratory Insufficiency
Other: continuous endurance training
Other: interval training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Effects of a Complex Pulmonary Rehabilitation Program on Patients With End Stage Lung Diseases Undergoing Evaluation for Lung Transplantation (Pre-LTx)

Resource links provided by NLM:

Further study details as provided by Klinikum Berchtesgadener Land der Schön-Kliniken:

Primary Outcome Measures:
  • Effects of a multimodal pulmonary rehabilitation program on physical activity measured via 6 minute walking distance(6MWD) [ Time Frame: day 1, day 14 and day 21 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Dyspnoea; Health Related Quality of Life (HRQL) in pre-LTx-Patients; PaCO2-behavior during training; Comparison of CT- and IT-Methode; Prevalence of anxiety and depression (HADS) in patients with end stage lung disease undergoing rehabilitation [ Time Frame: day 1, day 14 and day 21 ] [ Designated as safety issue: No ]

Enrollment: 60
Study Start Date: July 2008
Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
interval training
interval training in lung transplant candidates
Other: interval training
at 100 percent of peak Watt
Continuous Training
continuous training in lung transplant candidates
Other: continuous endurance training
at 60 percent of peak Watt

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • pre-LTx (listed for lung-transplantation or currently undergoing evaluation)
  • COPD Stadium IV GOLD
  • α-1-Antitrypsin-deficiency-Emphysema
  • respiratory Insufficiency
  • oxygen therapy (LTOT)

Exclusion Criteria:

  • serious Exacerbation (Symptoms longer than three days, change of therapy, e.i. antibiotics, steroids) during the last four weeks before rehabilitation
  • clinical signs of manifest heart insufficiency
  • acute coronar syndrome
  • left heart insufficiency(EF < 40%)
  • missing Compliance
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00962078

Klinikum Berchtesgadener Land
Schönau am Königssee, Germany, 83471
Sponsors and Collaborators
Klinikum Berchtesgadener Land der Schön-Kliniken
Study Director: Klaus Kenn, Dr.med. Klinikum Berchtesgadener Land, Schön-Kliniken
  More Information

No publications provided

Responsible Party: Klaus Kenn, Dr, Klinikum Berchtesgadener Land der Schön-Kliniken
ClinicalTrials.gov Identifier: NCT00962078     History of Changes
Other Study ID Numbers: PRÄ-LTX-08022, Ethikkommission, Landesärztekammer Bayern, Nr. 08022
Study First Received: July 27, 2009
Last Updated: November 10, 2011
Health Authority: Germany: Ethics Commission

Keywords provided by Klinikum Berchtesgadener Land der Schön-Kliniken:
Intervall versus continuous training

Additional relevant MeSH terms:
Pulmonary Valve Insufficiency
Respiratory Insufficiency
Cardiovascular Diseases
Heart Diseases
Heart Valve Diseases
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms
Signs and Symptoms, Respiratory

ClinicalTrials.gov processed this record on August 31, 2015


text:
Ixabepilone and Temsirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
First received: June 16, 2011
Last updated: July 23, 2015
Last verified: April 2015

This phase I trial studies the side effects and best dose of ixabepilone and temsirolimus in treating patients with solid tumors that have spread from the primary site to other places in the body or cannot be removed by surgery. Drugs used in chemotherapy, such as ixabepilone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving ixabepilone together with temsirolimus may kill more tumor cells.

Condition Intervention Phase
Adult Solid Neoplasm
Drug: Ixabepilone
Other: Pharmacological Study
Drug: Temsirolimus
Phase 1

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase I Study of Ixabepilone and Temsirolimus in Adult Patients With Advanced Solid Tumors

Resource links provided by NLM:

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • MTD of the combination of ixabepilone and temsirolimus, defined as the dose level below the lowest dose that induces dose-limiting toxicity in at least one-third of patients (at least 2 of a maximum of 6 new patients) [ Time Frame: 21 days ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Best response, defined to be the best objective status recorded from the start of the treatment until disease progression/recurrence [ Time Frame: Up to 3 months ] [ Designated as safety issue: No ]
    Responses will be summarized by simple descriptive summary statistics delineating complete and partial responses as well as stable and progressive disease in this patient population (overall and by tumor group).

  • Incidence of adverse events graded according to National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 [ Time Frame: Up to 3 months ] [ Designated as safety issue: Yes ]
    The number and severity of all adverse events (overall, by dose-level, and by tumor group) will be tabulated and summarized in this patient population.

  • Incidence of overall toxicity graded according to Common Toxicity Criteria standard grading [ Time Frame: Up to 3 months ] [ Designated as safety issue: Yes ]
    Frequency distributions, graphical techniques and other descriptive measures will form the basis of these analyses.

  • Time to progression [ Time Frame: Up to 3 months ] [ Designated as safety issue: No ]
  • Time to treatment failure [ Time Frame: From registration to documentation of progression, unacceptable toxicity, or refusal to continue participation by the patient, assessed up to 3 months ] [ Designated as safety issue: No ]
  • Time until any treatment related toxicity [ Time Frame: Up to 3 months ] [ Designated as safety issue: Yes ]
  • Time until hematologic nadirs (white blood cells, absolute neutrophil count, platelets) [ Time Frame: Up to 3 months ] [ Designated as safety issue: No ]
  • Time until treatment related grade 3+ toxicity [ Time Frame: Up to 3 months ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 30
Study Start Date: June 2011
Estimated Primary Completion Date: June 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Treatment (ixabepilone, temsirolimus)
Patients receive ixabepilone IV over 3 hours on day 1 and temsirolimus IV over 30-60 minutes on days 1 and 8. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: Ixabepilone
Given IV
Other Names:
  • (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
  • Azaepothilone B
  • BMS 247550
  • BMS-247550
  • BMS247550
  • Epothilone
  • Epothilone-B BMS 247550
  • Ixempra
Other: Pharmacological Study
Correlative studies
Drug: Temsirolimus
Given IV
Other Names:
  • CCI-779
  • CCI-779 Rapamycin Analog
  • Cell Cycle Inhibitor 779
  • Rapamycin Analog
  • Rapamycin Analog CCI-779
  • Torisel

Detailed Description:

I. To determine the maximally tolerated dose (MTD) of the combination of ixabepilone and temsirolimus in patients with advanced solid tumors.

II. To describe toxicity profiles associated with the combination of ixabepilone and temsirolimus.

III. To assess preliminary efficacy of the combination of ixabepilone and temsirolimus.

OUTLINE: This is a dose-escalation study.

Patients receive ixabepilone intravenously (IV) over 3 hours on day 1 and temsirolimus IV over 30-60 minutes on days 1 and 8. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for 3 months.

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Adult patients with histologically confirmed solid tumor malignancy that is metastatic or unresectable and for which standard curative measures or other therapy that provide survival benefit do not exist or are no longer effective
  • Patients may not have had more than two systemic therapeutic regimens in the metastatic disease setting with the following exceptions: hormonal therapy (e.g. tamoxifen, aromatase inhibitors, anti-androgen therapy, etc.)
  • Patients with non-measurable, but assessable, disease will be allowed
  • Absolute neutrophil count >= 1500/mcL
  • Hemoglobin >= 9.0 g/dL
  • Platelets >= 100,000/mcL
  • Total bilirubin < 1.5 mg/dL
  • Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) or serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 2.5 x institutional upper limit of normal (ULN) in the absence of hepatic metastasis; SGPT (ALT) =< 3 x ULN or SGOT (AST) =< 5 x ULN in the presence of hepatic metastasis
  • Creatinine =< 1.5 x ULN
  • International normalized ratio (INR) =< 1.4 for patients not on warfarin (Coumadin)
  • INR range of 2.0-3.0 for patients on therapeutic doses of warfarin (Coumadin)
  • Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2
  • Ability to provide informed consent
  • Willingness to return to a Mayo Clinic institution for follow up
  • Life expectancy >= 84 days (12 weeks)
  • Women of childbearing potential only: negative serum pregnancy test done =< 7 days prior to registration

Exclusion Criteria:

  • Known standard therapy for the patient's disease that is potentially curative or definitely capable of extending life expectancy
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, uncontrolled diabetes or with hemoglobin A1c (HbA1C) > 8, or psychiatric illness/social situations that would limit compliance with study requirements
  • Any of the following prior therapies:

    • Chemotherapy =< 28 days prior to registration
    • Mitomycin C/nitrosoureas =< 42 days prior to registration
    • Immunotherapy =< 28 days prior to registration
    • Biologic therapy =< 28 days prior to registration
    • Radiation therapy =< 28 days prior to registration
    • Radiation to > 25% of bone marrow
  • Failure to fully recover from acute, reversible effects of prior chemotherapy regardless of interval since last treatment
  • New York Heart Association classification III or IV
  • Known central nervous system (CNS) metastases or seizure disorder; patients with known brain metastases that have been successfully treated and stable for > 6 months without requirement for corticosteroids and without seizure activity will be eligible
  • Any of the following:

    • Pregnant women
    • Nursing women
    • Men or women of childbearing potential who are unwilling to employ adequate contraception
  • Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational (utilized for a non-Food and Drug Administration [FDA]-approved indication and in the context of a research investigation)
  • Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens
  • Immunocompromised patients (other than that related to the use of corticosteroids) including patients known to be human immunodeficiency virus (HIV) positive
  • Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm
  • History of myocardial infarction =< 168 days (6 months), or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias
  • >= Grade 2 sensory neuropathy
  • >= Grade 2 hypertriglyceridemia
  • >= Grade 2 hypercholesterolemia
  • Patients on medication considered strong cytochrome P450 3A4 (CYP3A4) inducers (efavirenz, nevirapine, carbamazepine, phenobarbital, phenytoin, pioglitazone, rifabutin, rifampin, St. John's wort) or CYP3A4 inhibitors (indinavir, nelfinavir, ritonavir, clarithromycin, itraconazole, ketoconazole, nefazodone, saquinavir, telithromycin) unless the medication can be substituted with another agent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01375829

United States, Florida
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Principal Investigator: Keith Bible Mayo Clinic
  More Information

No publications provided

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01375829     History of Changes
Obsolete Identifiers: NCT02344147
Other Study ID Numbers: NCI-2012-02907, NCI-2012-02907, NCI-2011-01140, CDR0000702380, NCI-2012-01136, MC1013, 8814, P30CA015083, U01CA069912, UM1CA186686
Study First Received: June 16, 2011
Last Updated: July 23, 2015
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Anti-Bacterial Agents
Anti-Infective Agents
Antibiotics, Antineoplastic
Antifungal Agents
Antimitotic Agents
Antineoplastic Agents
Immunologic Factors
Immunosuppressive Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses
Tubulin Modulators

ClinicalTrials.gov processed this record on August 31, 2015


text: id,summary,reporter,owner,description,type,status,component,version,severity,resolution,keywords,cc,stage,has_patch,needs_docs,needs_tests,needs_better_patch,easy,ui_ux 19556,Extend url include to search all packages in a namespace path,mcanix@…,nobody,"When installing django eggs in the same namespace it is required to include each egg in the settings.py INSTALLED_APPS variable. The following patch is intended to reduce the configuration when installing additional modules by only including the namespace and adding {{{ urlpatterns += patterns('', (r'', include('urls', 'namespace')), ) }}} The patch will search all package paths declared in the namespace and collect each urlpattern to create a consolidated urlpattern attribute which it appends to the last urlconf_module to return",Cleanup/optimization,closed,Core (URLs),1.4,Normal,needsinfo,urls eggs,hirokiky@…,Unreviewed,1,1,1,1,1,0


text:
December 31, 2011

Another historic win

Behind a game-high 17 points from Jordan Hulls, key plays from Victor Oladipo and Christian Watford in the final minute and strong team defense, Indiana upset No. 2 Ohio State 74-70 Saturday night becomming the first Hoosier team in program history to beat the No. 1 and No. 2 team in the same season.

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