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Keary Colbert completes improbable comeback

K. Colbert AP

USC wide receivers have a knack for improbable comebacks.

One year after Mike Williams returned from a few years out of the league to star in Seattle, Keary Colbert has made the Chiefs 53-man roster.

Colbert hasn’t played in the NFL since 2008.  He was in the UFL in 2009 and was a coaching assistant under Lane Kiffin at USC in 2010.  That will make anyone want to return to the field.

When Colbert announced his decision to return, we noted that he had an uphill battle to make a roster.  He picked the right team in Kansas City and apparently had an impressive camp.

A former second round pick of the Panthers, Colbert’s best season came as a rookie in 2004 with 754 yards.  If Colbert follows Williams’ path, we’ll be hearing from him again.

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11 Responses to “Keary Colbert completes improbable comeback”
  1. skoobyfl says: Sep 5, 2011 8:35 AM

    Just like Lienart, you’ll hear little noise from him during gameday.

  2. flavordave says: Sep 5, 2011 8:36 AM

    Tikis flabbergasted by this news.

  3. ak18346 says: Sep 5, 2011 8:50 AM

    Everyone in Charlotte hope you have a great season .

  4. catman72 says: Sep 5, 2011 8:53 AM

    Colbert was always a good practice/preseason player, but when the real games start he’ll let you down…

  5. thevalsalvamanouvre says: Sep 5, 2011 9:13 AM

    He was so unbelievably bad when he was with Seattle in 2008. Every pass to him *CLANK* off of his hands.

  6. jredshoes says: Sep 5, 2011 9:57 AM

    The light goes on for people at different speeds. Todd Haley (for all his faults) is a pretty good evaluator of receivers. I’d rather have someone who had to work through adversity and appreciates the NFL do well then some of the other knuckleheads with their diva mentality

  7. bnwillard says: Sep 5, 2011 10:03 AM

    Take it from a Panthers PSL holder, Colbert can’t ball. He can’t create separation from defenders on game day. Secondaries eat this guy’s lunch for him. The fact he’s being picked up gives you an idea of the dire shortage of decent wideouts in this league nowadays

  8. hyperalgesia says: Sep 5, 2011 10:44 AM

    How bad must things be with Baldwin to threaten him with an assistant college coach?

  9. jimmysimpson55 says: Sep 5, 2011 1:00 PM

    I guess it is true, mostly insecure people with anger issues because daddy did not give them enough hugs, really do like to root against happy endings.

  10. Mr. Wright 212 says: Sep 5, 2011 3:01 PM

    flavordave says: Sep 5, 2011 8:36 AM

    Tikis flabbergasted by this news.
    LMFAO I love that. We hate him in New York and couldn’t happen to a “BETTER” guy.

  11. Mr. Wright 212 says: Sep 5, 2011 3:02 PM

    He stinks, but hopefully he will turn it around.

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Comments on: Jake Locker “felt really good” in return to field ProFootballTalk on Tue, 01 Sep 2015 16:09:40 +0000 hourly 1 By: kush118 Wed, 28 May 2014 01:05:52 +0000 NFL lifetime completion percentage:
Jake Locker 57.2
Andrew Luck 57.0

NFL lifetime QB rating
Jake Locker 81.1
Andrew Luck 81.5

Things you don’t hear in the media.

By: rascalmanny Wed, 28 May 2014 01:01:22 +0000 Can’t believe some still believe in VY. After 5 years he still didn’t know the play book. LOL.

VY should thank Fisher and his former Titans team for winning despite his incompetence.

The Titans are STILL trying to get over those years.

By: j0esixpack Tue, 27 May 2014 22:59:22 +0000 I’m no Titans fan but the few times I saw Locker play healthy he looked like a keeper

IF he stays healthy he may be the answer

It’s a worthwhile gamble

By: evansvc Tue, 27 May 2014 22:37:54 +0000 What would it hurt???? Take a look at Vince Young…..
There are a lot worse QBs on NFL rosters that has never had the success Vince Young has had …(NFL Rookie of the Year, 2 Pro Bowls, Playoff experience and Mobility). Vince has a career winning record of 31-19…
He can help this team…even if it’s just upgrading the quarterback pool…

By: fordmandalay Tue, 27 May 2014 21:14:55 +0000 No report as yet on how Titans fans feel.

By: thepftpoet Tue, 27 May 2014 20:22:02 +0000 Jake Locker had a 55% completion percentage in college.

Yes, after playing medicore college talent.

He will be a career backup after this year.

By: tennesseeoilers Tue, 27 May 2014 20:16:05 +0000 It’s amazing to me how many Titans fans are writing Jake Locker off. Being in his corner really takes me back to the good ol’ days. It’s just like being a Steve McNair fan circa 1997 – 99. I mean, this is fun. … It’s like you can see something so many other fans can’t.

By: thesmartest1 Tue, 27 May 2014 20:12:17 +0000 He felt good when drafted too.

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I have a "pipeline" sort of process that is essentially just linking together a bunch of existing tools to automate a workflow. For one of the steps, there is an existing command-line tool that already does the meat of what that step needs to do.

The external CLI tool is java-based, and so is my pipeline, so it would be possible to integrate the tool directly into the pipeline step, but the tool is very complex and is currently closely tied to having command-line input (something like 37 config flag options).

The question is: Is it a better idea to simply call out and invoke the external process, or would it be better to integrate the external code within my application?

What are the pros / cons of integrating vs. calling the external process?

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Is the command-line tool something you control, or is that developed by another party? –  whatsisname Feb 1 '12 at 15:41
It's the open source (Mozilla license) dcm4che DICOM toolkit, so it's been developed by another party, but I can do with it pretty much whatever I wish. –  cdeszaq Feb 1 '12 at 15:47

4 Answers 4

Is it a better idea to simply call out and invoke the external process, or would it be better to integrate the external code within my application?

It is much better to integrate these things.

The command-line interface is just an interface, and a particularly awful one. It's essential but it's also filled with quirks and limitations that aren't sensible.

Each of the "existing tools to automate a workflow" should have a tidy class that does the real work after the command-line options have been parsed.

Ideally, the public static void main function does two things in each one of those "existing tools".

  1. It invokes some command-line option/argument parser.

  2. It invokes the tidy class that does the real work. Think of an Ant task or a Maven task that does the real work after Ant or Maven has handled all of the parsing and decision-making.

When you go to integrate these things, you want the tidy classes that do the real work.

If they don't exist, then you'll have to rewrite all of those tools to create the tidy class that does the real work, separate from all command-line parsing.

For guidance on how these tidy classes should work, read Ant (or Maven) to see how they define the various worker tasks. It's a good mental model for how multiple, disparate things are integrated without going back to the command line.

share|improve this answer
In my case, the class doing the work is the entire tool, and contains the main method, the CLI-parse methods, etc. It's rather nasty :( –  cdeszaq Feb 1 '12 at 15:50
@cdeszaq: In that case, it needs to be fixed. It's not a terribly difficult rewrite, and it must be done. –  S.Lott Feb 1 '12 at 15:56
I'd add that depending on your deadlines, you could integrate with the existing CL interface and port over to a properly integrated solution over time. But if you do have time to fix this now, then do so :-) –  Martijn Verburg Feb 1 '12 at 16:03
@MartijnVerburg: Good Point. Often, there's a clear priority. Some of the workflow is more tightly integrated or could potentially have a separate use as a "sub-workflow". This may lead to a backlog of rework from most valuable to least valuable. –  S.Lott Feb 1 '12 at 16:27
At my last employer we had a problem executing a utility exe (we but not my code at all). Helping the "senior" developer diagnose why this exe wouldn't execute I suggested writing a bat file to kick it off. It worked. He stopped looking for the problem and thats how it went out the door. Lesson I learned is 1. Never propose a bad idea to troubleshoot a problem to someone that makes decisions. 2. Use libraries or internalize your own logic as much as possible. That "fix" cost a host of tech support on some machines. He also didn't believe in testing or source control so no surprise... –  Rig Feb 1 '12 at 18:09

I would say leave it alone if it works.

As a programmer you bring value to your organization by solving problems with software. Solving more problems in both quality and quantity within a given amount of time is directly related to your value in the organization. Spending this time to create code diminishes your value since it takes you away from solving a more important problem.

However, a couple of factors that might mitigate spending the time would be scalability and if there were any concerns for the external programs stability.

share|improve this answer
I agree. You can open yourself up to a lot of trouble trying to integrate 3rd party programs/code into your app. Sometimes it is necessary but, as the saying goes, "If it ain't broke, don't fix it" –  jfrankcarr Feb 1 '12 at 16:21
Solving problems is great. Solving some problems while opening the door to other problems is not so great. –  yfeldblum Feb 2 '12 at 1:42

It isn't "better" or "worse". There are simply different costs and benefits.

It is often more expensive to write and maintain a piece of software the larger the number of integration points do to the added complexity.

  • A function you write has very little integration cost.
  • A third party library has slightly larger integration cost.
  • A separate program you have to exec will have and even larger integration cost.

Note these are integration costs which you have to weigh against total cost which includes among other things the cost for writing and maintaining software.

It may be the case that you are a very inexperienced programmer, but a long time power user.

  • If you were to "shell out" your total cost may be low despite the higher integration cost, because you can mitigate the integration cost with your experience and knowledge.
  • If you were to write the function yourself your total cost may be quite high despite the low integration cost because of your inexperience programming.

The best way to figure out:

Is it better idea to call an external command-line application or to internalize that application's logic?

Is to calculate the costs for yourself. The cost will be different for different environments, situations and people. Most of the time it will cost more to call out to the command line, but not always and the only way to be sure it to do the analysis.

share|improve this answer
In my case, it is essentially a external application that happens to be open-source and written in Java, just like my application. Unfortunately, there isn't simply a library the external application uses, since that library is bundled tightly into the CLI interface itself. Other than that, all good points. –  cdeszaq Feb 2 '12 at 13:21

Ideally you'd want to integrate it. Especially if this is an app that gets distributed - reducing the number of dependencies and configurations will make that easier. But its of course a cost/benefit issue for your specific case.

That said, one thing to consider is stability. I encountered something similar a couple of years ago and kept the cli program in place. It was too unstable, and I didnt want its crashing to take down the parent application, which needed to run 24/7. Now this wasnt a java app, but none the less, if its an issue that may apply you may want to keep that in consideration.

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I've just been compiling some of my own code with the -std=c++0x flag in GCC, as I want to vaguely keep up with what all the young folks are doing (provided they stay of my lawn), and I ended up with a load of warnings about auto_ptr being deprecated. Of course, I knew that auto_ptr was deprecated in C++0x, but...

Isn't deprecation a waste of time and effort? Reasons for not deprecating (with auto_ptr as an example):

  • there is an ocean of code out there that still needs to be supported, producing millions of warnings will only tempt people to turn warnings off.

  • auto_ptr is a bit naff, but it does actually do what it says on the tin.

  • if we really want to deprecate things, I nominate printf(). But just imagine the squeals that would ensue. auto_ptr doesn't have too many friends, but in at least my C++ code it is used more than printf, which isn't used at all.

  • the committee have a bad record of getting this right - they deprecated static at namespace scope, and now it seems to have been undeprecated - I wouldn't be surprised if auto_ptr made a similar come-back

  • lastly, whatever the committee say, the compiler implementers ignore them - they simply can't risk breaking their customers code, all they can do is issue irritating warnings.

So my question - do you consider deprecation (of anything, not just auto_ptrs, and not just in C++) a good idea, and if so, why?

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closed as primarily opinion-based by gnat, GlenH7, Robert Harvey, Kilian Foth, MichaelT Dec 6 '13 at 2:28

Many good questions generate some degree of opinion based on expert experience, but answers to this question will tend to be almost entirely based on opinions, rather than facts, references, or specific expertise. If this question can be reworded to fit the rules in the help center, please edit the question.

@TheLQ - I read it as "why depreciate anything" but using auto_ptr as an example. –  ChrisF Jun 11 '11 at 19:21
does it say on the tin "will break your heart if used in containers of almost any kind"? Use unique_ptr and be happier. –  Kate Gregory Jun 11 '11 at 20:08
@Neil - your language is a little inflammatory and (on reflection) it does come across as more of a rant than a serious question. If you want it to remain open you might want to "tone it down". –  ChrisF Jun 11 '11 at 21:16
@Neil - I appreciate that you had intended it as humorous, but as I said, on reflection it came over more "ranty" than I think you intended. –  ChrisF Jun 11 '11 at 21:43
If you ever plan of getting rid of deprecation, you should really deprecate it first. Lots of existing languages/APIs would break otherwise. With deprecation you could give them some time to get rid of their deprecated deprecations. –  Joachim Sauer Dec 3 '13 at 13:22

8 Answers 8

Reasons for deprecation (in general):

  • It clearly indicates to people that something is bad practice (and hopefully suggests an alternative).
  • The deprecation period gives people a chance to change their code before the compiler removes it outright.

I also disagree about the last point. Compilers don't ignore the committee, and they do eventually remove things that are deprecated (e.g. >?= and <?= in GCC -- they were deprecated then removed*).

I think the important point is: some things should be removed, for various reasons, and I think deprecation is the only sane way to do that. In this specific case, auto_ptr should be removed as it has been superseded by unique_ptr. Changing over is easy enough, and people will have plenty of time to do so.

(*) Yes I know they are extensions and not standard, but the point is that compiler vendors do eventually remove things once they enter deprecation, whether code still relies on them or not.

share|improve this answer
Sorry for the offtopic, but I can't resist: what were those >?= and <?= operators? –  brandizzi Dec 22 '11 at 14:59
In old GCC you could write a >?= b; which was shorthand for if (a > b) a = b; and likewise for <?=. –  Peter Alexander Dec 22 '11 at 15:40
Ugh... I can see why they added it. And then why they removed it. Deprecation can be necessary for the "neat" features that only reveal how problematic they are after they are released to the public. –  Phil Dec 3 '13 at 15:05

Any sufficiently complicated API will likely have flaws that are not discovered until after they've been used for a while. Our options:

  • Leave things as they are. This means the API will continue to gather more and more cruft as it evolves over time. Even if new and improved versions are added, the old ones will need to be kept maintained as well.
  • Remove it without warning. This is likely to break a lot of code.
  • Deprecate it and remove it in a later version. This gives time to fix existing code, while ensuring that the amount of cruft stays bounded.

Deprecation is the sanest of these alternatives.

share|improve this answer

Nah. Deprecation can be a really good thing. It keeps technologies from getting stuck with old useless baggage.

Just in the C++ arena, I remember Microsoft's "feature" of not correctly supporting variable declaration inside a for statement. That went on for about a decade and made a lot of code non-portable. That's one "feature" I'm glad was deprecated.

More generally, Apple has had a habit since the 80s of marking clunky old APIs as "deprecated" for 5-7 years before yanking them. I was just talking with an Apple engineer at WWDC about deprecating some of the ancient QuickTime C APIs, and was really delighted to hear they were doing that, because continued support for a model developed around 1990 was completely obstructing what one would expect to be able to do on modern 64-bit multicore CPUs.

In practice, it's going to take compiler writers a long time to dump auto_ptr, and they'll probably support some backwards-compatibility mode for a decade or two, but it's a good thing imo.

share|improve this answer

if we really want to deprecate things, I nominate printf()

printf is a useful function. It allows for formatting things ways shorter than iostreams. And it's a C function. The very reason C++ exists and is used is because it's compatible with C. So deprecating printf seems less useful.

So, anyone else up for an anti-deprecation crusade?

The committee is aware of some of the problems of the current supposed meaning of deprecation. See the meaning of deprecation.

share|improve this answer
@Neil now that you have adapted your question, I can adapt my answer :) –  Johannes Schaub - litb Jun 11 '11 at 21:36
The "meaning of deprecation" link does not work anymore. It points somewhere, but the document no longer discusses meaning of deprecation. –  Jan Hudec Dec 3 '13 at 14:13
@JanHudec: The link should work again –  Bart van Ingen Schenau Dec 4 '13 at 18:16

Languages and APIs have to move forward. Even though there might be a ton of code depending on some old feature, there might be a new and better way to do something and the cost of supporting the old feature is just too much.

Deprecation also gives warning that in the future, the feature will be removed. This gives developers time to update their code if they are keeping up with the new API. This is much better than the alternative: outright removal. Remember that depreciation is a warning, not an error.

And if this is an old program that you don't want to update, then nothing is stopping you from using the old API (or in this case compiler).

share|improve this answer

As it stands, deprecation has at least two meanings.

  • It is going to be removed in a future version
  • We created better alternatives and now the feature is redundant (but not entirely useless). Newcomers would better skip this while learning the language; however, it is not going to be removed any time soon.

I think static falls into the latter category, but only time will tell if auto_ptr really deserves to be removed or if it's better to keep it in the language.

share|improve this answer

Deprecation is not harmful if moving to an alternative can be done in 1 work day: eg. simple search/replace of the old function with the new, or a compatibility layer is easy to set up.

If you need to rewrite large parts of the software because of the deprecation, then it's harmful.

A good example would be probably the PHP's mysql API, basically you simply need to replace all mysql_* with mysqli_* and provide a link id to them and it's done.

One bad example is the deprecation and removal glBegin, glEnd, and all matrix computation stuff from OpenGL, if you want your code work on OpenGL3 or above, you'll need to rewrite the whole rendering code to use vertex buffers.

share|improve this answer

I think it is a good way of letting people know that there is a better way. I much prefer a nice deprecation rather than a function just disappearing.

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Rangers ease Marc Staal in as he returns in Winter Classic

Jan 2, 2012, 7:51 PM EDT

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staalsimmonds AP

For the second Winter Classic in a row, a Staal brother made a surprising return from injury. Marc Staal actually received less ice time than Jordan did in the 2011 Winter Classic, but the New York Rangers were still heartened to see their crucial defenseman back in action in the 2012 edition.

Andrew Gross reports that Marc Staal made the call during dinner last night after a stomach-churning week of pondering the choice. After “writing off” the possibility of coming back on Jan. 2 for quite some time, Staal began to ponder playing once concussion specialist Dr. Robert Cantu cleared him for contact a week ago.

Henrik Lundqvist said that Staal’s return “gives the whole team confidence,” even though it was clear that head coach John Tortorella was easing him back into the mix. Staal received 12:41 of ice time, which is well off his 25:44 minutes per game average from last season. Still, Staal said that he felt more comfortable as the Winter Classic went along, as you can see from this video from his post-game press conference.

Top 10 NHL Player Searches
  1. P. Kessel (1801)
  2. P. Kane (1446)
  3. M. Richards (1301)
  4. P. Datsyuk (1294)
  5. N. Backstrom (1150)


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Caps players didn’t care much for fan’s signs during warmup

Mar 7, 2012, 10:00 AM EDT

Picture courtesy of: @KnublesKnights Picture courtesy of: @KnublesKnights

Since Dale Hunter has taken over for Bruce Boudreau behind the Washington bench, one player that’s been phased out of action for the Caps is fan-favorite Mike Knuble.

Knuble’s been a healthy scratch more often than not lately, and with the team losing, some fans calling themselves “Knuble’s Knights” brought signs of protest to the game. However, they were soon told to take them down.

With one sign reading “Free Knuble” and the other reading “Scratch Hunter” you can see where this might make just about everyone on the team uncomfortable. Katie Carrera of The Washington Post explains what happened during the team’s warmups.

According to a Capitals spokesman, three players saw the signs during warmups and asked that they be taken down. They were primarily concerned with the sign that read “Scratch Hunter,” the spokesman said.

Things are ugly in Washington and Knuble hasn’t been very good. Still, seeing how the players got this bothered by a couple of signs that said mostly harmless things makes you wonder what life’s like in that locker room (Hint: It’s probably not a lot of fun).

(Photo courtesy of Knuble’s Knights via Twitter)

  1. hawknuts - Mar 7, 2012 at 10:36 AM

    i knew the capitals were a bunch of phussies on the ice but i didn’t know they were also sensitive phussies…im sure with all the daggers hunter has thrown in his day this means very little to him, if anything at all. make the playoffs and people won’t bring this crap to the rink to remind you of how bad your choking.

    • dagnats - Mar 7, 2012 at 10:52 AM

      choking…? they haven’t been good all year…choking implies that they were good at one point this season…they are just below average this year

      • brianforster - Mar 7, 2012 at 2:34 PM

        set a franchise record for consecutive wins, destroyed detroit in an early battle of the unbeatens… at one point there was hope for us this season! 😦

  2. hawknuts - Mar 7, 2012 at 11:04 AM

    i guess your right but i figure a team with one of the supposedly top 3 players in the league could make a run when the bottom teams in the conference are all fighting for the final playoff spot. i.e choking

    but you are right, this team has been garbage for a long time and will continue that way until they fire george mcphee and maybe even hunter. leonsis needs to act now to save oveckins relationship with the capitals or its going to get ugly when he asks out.

  3. bcisleman - Mar 7, 2012 at 11:38 AM

    All I can say is that I still remember what Hunter did at the Coliseum in 1993. He should have been arrested for what he did to Pierre Turgeon. Anything bad that has ever happened to him since–including this year–is well deserved hockey karma. If he were a man, he’d go to Turgeon, look him in the eye, and apologize. Don’t think he’s done that.

  4. killerpgh - Mar 7, 2012 at 11:58 AM

    What next? Throwing fans out for booing?
    Without looking back I think the Capitals did start the season on fire. 7 wins to start the season off. So “choking” could fit if I’m right. This team is to good to miss the playoffs.

  5. mgp1219 - Mar 7, 2012 at 12:53 PM

    I always hated the Hunters (all of them) for how they played and that hit on Turgeon many years ago corroborated my opinion about Dale.

Top 10 NHL Player Searches
  1. P. Kessel (1804)
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  3. M. Richards (1303)
  4. P. Datsyuk (1295)
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Report: Flyers want goalie with ‘no or one-year left’ on deal

Jun 29, 2013, 5:17 PM EDT

Jaroslav Halak Getty Images

When Flyers GM Paul Holmgren was searching for a goaltender in the summer of 2011, he signed Ilya Bryzgalov to a massive nine-year, $51 million contract. That didn’t work out and it sounds like they aren’t interested in repeating history.

Holmgren is looking to acquire a goaltender once again, but this time he wants one with “no or one-year left” so he can “get a read on that player before committing,” according to a CSN Philly source.

Finding a capable starting goaltender that will become a free agent in the summer of 2014 isn’t impossible, but certainly his options are limited. St. Louis’ Jaroslav Halak would fit that description and he’s already been linked to Philadelphia.

Buffalo’s Ryan Miller is the other noteworthy possibility and the Sabres are gauging the trade market for him. However, he comes with a $6,250,000 annual cap hit, which would be hard for the Flyers to handle unless Buffalo retains some of it.

An alternative is Evgeni Nabokov, who is scheduled to become an unrestricted free agent. At the age of 37, Nabokov will probably only be looking for a one or two-year deal.

It’s worth noting that this might not be entirely about just avoiding going through a situation similar to the one they had with Bryzgalov. Steve Mason was great in his short stint with the Philadelphia Flyers, but he was also coming off years of struggles with the Blue Jackets.

Philadelphia might not be comfortable having him serve as the team’s starter in 2013-14 given his history, but if he has another strong season, they might want the flexibility to use him as their undisputed number one in 2014-15.

  1. icelovinbrotha215 - Jun 29, 2013 at 5:47 PM

    Well it shows that they don’t want to be locked in to a mortgage like contract. You still have no long-term plan though…

    • wreckemrinaldo21 - Jun 29, 2013 at 5:58 PM

      As of now Mason and Stolarz are the long term plan. Can not discredit Mason’s play down the stretch. People are on the Brobovsky band wagon, but Mason had similar numbers on a worse team. Personally I think the flyers are going to experience the second coming of Ray Emery.

    • hockeyfan28 - Jun 29, 2013 at 10:52 PM

      Anthony Stolarz is the long term plan he won’t be ready for a few more years but he’s the heavy favorite to be the team USA goalie at the World Championships in Dec boy can play

  2. ciarram84 - Jun 29, 2013 at 5:55 PM

    can not wait til tomm should be a very exciting day.

  3. phillyphanatic77 - Jun 29, 2013 at 6:05 PM

    Wouldn’t it be crazy if, unable to reach an agreement, the Blue Jackets send Bobrovsky’s rights back to Philadelphia? It’s highly unlikely but all reports indicate that no progress has been made between the two sides, and instead of simply losing a young, up-and-coming goalie to the KHL, maybe they get something for his rights. Just a pipedream.

    I’d be very happy with Halak though. I’m hoping something happens tonight.

    • iHeartHockey31 - Jun 29, 2013 at 8:20 PM

      The reason Bob started playing well in Columbus is because their goalie coach recognized a problem with Bob’s stance [he wasn’t sitting up high enough in his butterfly — which caused other issues like not having his glove positioned correctly.] He then worked with Bob [during the summer, prior to the lockout] & all year long to correct his stance and tweak his game]. In the 2 years that Bob played for Philadelphia, Jeff Reese either never noticed this problem or wasn’t able to communicate instructions clearly effectively enough to improves Bob’s game. Unless Philadelphia intends to find a new goalie coach, it’s unlikely that [1] Bob would want to come here or [2] that he’d continue to be successful under Jeff Reese.

      Mason didn’t just play well in his last few games, his career stats vs Eastern Conference teams are REALLY good [.923]. [You know those teams we play 54 games against & the first 3 playoff rounds]. His biggest problem was being stuck on a Western Conference team when he’s more suited to playing against teams in the East. [Other issues include having been the goaltender for the worst team in the league & not playing in a city with a large hockey fanbase].

      One of the most notable things about the 7 games he played for Philly, wasn’t even his play, it was the play of the guys in front of him. The team PLAYED better when he was in net. They trusted him behind them & played a better game when they weren’t worried about whether or not their goaltender was going to be ducking out of the way of pucks. Even if Mason doesn’t turn out to be the greatest goaltender, at least the team can get their attention back on the offensive game & go back to winning games like they used to – by scoring more goals then they let in.

      Besides. He’s so pretty to look at :) Steve Mason [& Carey Price] are the hottest looking goalies in the whole league. It’s not like we could possibly have a season worse than last one. At least Mason is waaay prettier to watch in post-game interviews.

  4. nyrnashty - Jun 29, 2013 at 6:33 PM

    The Flyers should just keep Mason for now and select either Tristan Jarry, Eric Comrie or Zach Fucale with the 11th overall pick. Jarry would be a great pick for them. The Flyers need to worry more about their minor league D at this point than anything else. Can’t win with that D, even if they had Lundqvist or Quick in goal.

    • iHeartHockey31 - Jun 29, 2013 at 8:23 PM

      We never had the best D. We always made up for it by scoring more goals than we let in. This season instead of playing offense all 5 skaters had to stand in front of Bryzgalov because he couldn’t be trusted to keep the puck out.

  5. rockyspond - Jun 29, 2013 at 7:54 PM

    If the Oilers get dumb enough to (over)pay for Schneider, Holmgren can have Dubnyk for Cobourn; that would resolve at least part of both teams’ problems. For those of you who haven’t seen Dubnyk play often enough, he has all the tools to be Flyer’s #1 goalie, and has 1 year left at $3.5 before UFA status.

  6. laxman1944 - Jun 29, 2013 at 7:59 PM

    Just sit tight……….Be wise tomorrow please……

    Good hunting Paul

  7. chrisk61 - Jun 29, 2013 at 8:13 PM

    worse case is flyers sit tight at #11 and draft a D man. or they trade up, with a deal that includes coburn, but they keep their #11 and then grab 2 D men.

    i don’t think they will be too focused on their 2nd goalie tomorrow.

  8. megahockey - Jun 29, 2013 at 8:31 PM

    Really hoping Mason does well in Philly. Last years second rounder Anthony Stolarz could eventually become a decent starter/excellent backup.

  9. Habib Marwan - Jun 29, 2013 at 9:23 PM

    It really wouldnt hurt to have Ryan Miller for one season

    • Windmiller4 - Jun 29, 2013 at 9:37 PM

      It would hurt their cap space

    • megahockey - Jun 29, 2013 at 11:02 PM

      Totally agree that they need someone for 1-3 years. Just for the future.

  10. LampyB - Jun 29, 2013 at 10:24 PM

    Mason won’t become a #1 and Nabokov is old and will retire at his current level. Nothing stellar. Halak would be a fantastic option the test out for a season, should absolutely try and get this done. Halal had a bad season but was in the midst of a clusterf**k with two other net minders. Wasn’t really given a shot, and in 2011-2012 season he was unstoppable with Elliot

  11. jimw81 - Jun 29, 2013 at 10:58 PM

    Holmgren’s brilliant mind at work people. watch him give a goalie on ufa a ridiculous deal.

    sad part is that he can’t take a joke anymore.

    Some content was stripped by our security filters, but it should be possible for one of your Editors to embed the content for you.

  12. crazemastercraze - Jun 29, 2013 at 11:09 PM

    Either way, Flyers will mess it up worse than Mr. Bungle. It will be hilarious

  13. sizzle299 - Jun 29, 2013 at 11:50 PM

    Another day another PHT article citing csn philly or some other “report” from the Philly media. Please please stop citing these pathetic excuses for hockey reporters. These nutless monkeys just make up a different fake story every day which is essentially a headline and no substance.

    What will they without Bryz to quote instead of actually reporting on hockey??

    PHT stop writing articles if the only source is the media in Philly

  14. phillies816 - Jul 1, 2013 at 8:21 AM

    Can’t wait to watch this team underachieve again in 2014. I’ve never seen a team get such a pass in my life. Haven’t won jack squat since the mid 70s but the brain washed masses still accept it here in Philly. I’m tired of this team living in the 70s. Kate Smith, Bob Clarke, Bernie Parent, Bob Kelly, the “Broad Street Bullies”…want to bring back something from the 70s that really matters? Try the Stanley Cup. PATHETIC

Top 10 NHL Player Searches
  1. P. Kessel (1800)
  2. P. Kane (1438)
  3. M. Richards (1300)
  4. P. Datsyuk (1291)
  5. N. Backstrom (1148)


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Goodman A, Benjamin R, Dame T, Reid M, Rosolowsky E, Alves J, Robitaille T. The Hierarchical Structure of Star-Forming Regions in the Milky Way (NSF Proposal). 2011.Abstract
Intellectual Merit In September of 2011, several of us attended a meeting in Rome called “Milky Way 2011,” organized to showcase the plethora of recent surveys of star-forming material in our Galaxy. We were simultaneously excited and disappointed by the meeting: excited by the wealth of new data; and disappointed to see the lack of coordinated analysis of it. We went home determined to create a collaborative project offering a more synthetic understanding of star formation in the Milky Way. We, and many other astrophysicists, want to know how, where, and when a galaxy like the Milky Way forms stars. Presently, it is easier to answer this question empirically in nearby galaxies, thanks to our “external” vantage point with respect to those systems. But, that vantage point is far away, so our ability make predictive physical models of star formation based on observations of external spiral galaxies is limited, even with new instruments like ALMA. In the Milky Way, we have tremendously detailed studies of star-forming regions within a few hundred pc of the Sun, but none of these nearby regions contains any massive (O) stars characteristic of the star-forming regions observationally detected in external galaxies. Here, we propose to evaluate the star-forming potential of gas under the full variety of conditions observed the Dame et al. (2001) CO Survey of Molecular Gas in the Milky Way. We will not study only nearby clouds, or only massive star-forming regions, but instead every environment our Galaxy has on offer. Our work, using hierarchical “dendrogram” trees to deconstruct molecular gas emission, will be distinguished from previous analyses of star-forming clouds in the Milky Way by how it identifies significant structures within the gas. Essentially all previous work has divided up gas along sharp boundaries, without taking into account the obvious hierarchical nature of the gas. By analogy, this non-hiearchical approach is like dividing up whole metro Minneapolis-St. Paul into just two parts defined by a unique boundary between the cities. This approach takes no account of the fact that these two separate cities are surrounded by a combined “metropolitan area,” and further surrounded by a state called Minnesota that also contains other cities, like Duluth, each of which has its own identity, likely determined in part by its surroundings. We suspect that environment does matter, and that the artificial division of gas into non-overlapping clumps has masked important physical effects. By combining the hierarchical decomposition of star-forming material we will create with catalogs of associated dense star-forming “cores” and young stars, we will evaluate which of several potential physical processes is key to the formation of stars. In particular, we will study whether a feature’s self-gravity, its internal density or pressure distributions, or external pressure–or a combination of those–is most predictive of fecundity. Our results will clarify our understanding of star-formation in the Milky Way, and offer physical insights into empirical trends measured in other galaxies. Broader Impact The PI and several Co-Is are known for their work on data visualization, data sharing, and science education. All the products created in this work, including a 3D visualization of star-forming gas in the Milky Way, will be made available online through the, Astronomy Dataverse, Seamless Astronomy, and WorldWide Telescope sites, all of which the PI has had a hand in creating. The Astronomy Dataverse is presently being deployed as an NSF-data-management-plan-compatible solution for short-term distribution and long-term preservation of astronomical data, and this project will serve as a key demonstrator of the Dataverse’s utility. The new Milky-Way shaped Haus der Astronomie visualization and outreach facility in Heidelberg will play host to a meeting on “Star-Formation in the Milky Way, in 3D,” co-sponsored by the Max-Planck Institute for Astronomy as part of this project.


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        With a vintage style as fabulous as yours, who says that dressing up for homecoming has to cost a fortune? Unique Prom carries a selection of affordable homecoming dresses for thrifty fashionistas just like you, and each one is perfectly on trend with the retro styles that you love.
        Not everyone has the luxury of having an unlimited homecoming budget, but that doesn’t mean that you can’t have your dream dress for the big dance. With a bit of budget-savvy browsing – and Unique Prom’s impressive selection of cheap homecoming dresses – you can create a stunning prom look that won’t empty your wallet. Shop our entire selection of inexpensive homecoming dresses and you might even find one for less than $100!

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, , , ,

By Smaktakula

Get Creative With It. Dueling Doesn't Have To Be About Pistols.

Our progenitors were a proud people who would be wholly unfamiliar with our citified existence. Lacking our modern amenities and easy-access conveniences, these dim and shadowy relics of a bygone era placed an inordinate amount of value on intangibles, like honor–a thing easily besmirched in historical times. The loss of personal honor was no small thing to these people, and there were only a few means by which this honor could be reestablished.

Chief among these means was dueling, the ancient gentlemanly art of gaining satisfaction for a perceived wrong. Dueling has been outlawed in the civilized world for over a century (and in Uruguay since 1992), and in that time the global population has seen a precipitous drop in its collective honor.

Nerds Duel For A Final Answer To The Question: Which Captain--Kirk Or Picard--Was Superior?

Today, the pale descendants of these hot-blooded historical figures are but poor facsimiles of the barbaric and half-drunken men whose self-reliance made the advances of the 20th and 21st Centuries possible. Today’s citizen has as much or more pride as these gun-crazy ancients, but none of their honor.

For this reason, Promethean Times proposes a return to the glorious and time-honored practice of “seeking satisfaction.” Moreover, in keeping with America’s more egalitarian society, dueling must be made accessible to the lower classes in the same way as has golf, higher education and regular meals. By giving a chance at satisfaction to those individuals most inclined to take offense, society should have an excellent chance of curbing its excess asshole population.

See? Duels Can Be Adorable. There's Too Many Of These Little Fuckers Around Anyway.


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 Manly Cookbook [Dan Collins] | protein wisdom
June 28, 2008

Manly Cookbook [Dan Collins]

Courtesy of Fausta, Hog on Ice’s Steve Graham’s masculinist cookbook is now available.

Congrats, Steve.

At first, this seemed like an abomination; then I saw it was Coors.

Posted by Dan Collins @ 9:48pm
2 comments | Trackback

Comments (2)

  1. Thanks for the link! You are going to love Steve’s recipes.

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Dara Greenidge ’12 and Laurie Moise ’12 founded the Footprints
Gospel Choir.

Gospel Choir Founders Receive Leaving a Legacy Award

Two students who formed a Gospel choir share this year’s “Leaving a Legacy” Award, which acknowledges graduating seniors whose contributions to Providence College will continue beyond commencement.

Dara Greenidge ’12 (West Haven, Conn.) and Laurie Moise ’12 (Malden, Mass.) received the honor during the Student Recognition Program held by Office of Student Activities-Involvement-Leadership (SAIL).

The Office of Alumni Relations established the Leaving a Legacy Award to honor students who make a lasting impact on the College. The students do not have to have a parent who attended PC to be eligible for the honor.

During the 2010-11 academic year, Greenidge and Moise created the Footprints Gospel Choir. While open to all students, the choir has given students of color an opportunity to lead, serve, and share a heritage rooted in the tradition and history of Gospel music, contributing to campus diversity, said Elena Yee, director of the Balfour Office for Multicultural Activities, who nominated the pair.

Greenidge and Moise “truly deserve this award for their creativity, dedication, and commitment to the College’s core value of embracing diversity by starting a new organization, inviting all students to participate, and impacting their peers through the power of Gospel music,” wrote Yee.

The choir began with 10 students but has grown to 25, Yee noted. It gives campus-wide concerts twice a year, at Christmas and at a Gospel Jam in April. It also performed with the Liturgical Choir and at a Martin Luther King Jr. Scholarship Legacy celebration, and at various events in the local community.

Greenidge and Moise held leadership positions with the Board of Multicultural Student Activities, the African American Society, the A Cappella Club, and the Black Studies Advisory Committee.

Following commencement, Greenidge is participating in Teach for America in the New York City area. Moise is the first PC student to be selected for a Rotary Ambassadorial Scholarship and hopes to study in South Africa, Trinidad and Tobago, or Grenada.

Other SAIL Awards went to:

Service Leader of the Year: Hollis Dunlop ’12 (Marion, Mass.)

Unsung Hero: Joseph Neidermeyer ’12 (Colts Neck, N.J.)

Emerging Leader: Maria Pantazelos ’14 (Danvers, Mass.)

Student Leader of the Year: Marc Capuano ’12 (East Greenwich, R.I.) and Emily Foster ’13 (Wrentham, Mass.)

Advisor of the Year: Sharon Hay, Board of Programmers

Special Recognition Award: Elena Yee, director, Balfour Office for Multicultural Activities

Dirigo Leadership Honor Society Award: Paul Calle ’12 (Danbury, Conn.)

Dirigo Honorary Membership: Rev. James Cuddy, O.P. ’98, College chaplain

Awards also were presented to the following activities:

Most Successful Fundraiser: Relay for Life, by Colleges Against Cancer

Outstanding Service Project: Breadlines, by Campus Ministry

Outstanding Multicultural Program: Cultural Jamboree, by the Board of Multicultural Student Affairs

Outstanding New Event: Provapalooza, by Board of Programmers and Campus Ministry

Outstanding Event: Fashion Mania Fashion Show, by African-American Society

Special Recognition Award: Santa Shop, by Kevin Brawley ’12 (Rehoboth, Mass.)

Awards also were presented to campus clubs:

Outstanding Performance Organization: PC Pep Band

Outstanding Athletic Organization: Figure Skating Club

Outstanding Media Organization: PCTV

Most Improved Organization: Future Friar Executives

Outstanding New Organization: Ballroom Dance Club

Outstanding Organization: Colleges Against Cancer

— Vicki-Ann Downing

Read more about what's happening at the College at PC News.

Catholic and Dominican

What does it mean to be a Catholic and Dominican college? We invite you to explore this question and the distinctive mission of Providence College.
About Providence College's Catholic and Dominican Identity


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2 definitions by Chaz Castel

Top Definition
the result of waking up the morning after smoking marijuana and having a head ache, or any other symptoms reminiscent of a regular hang over hang over
I was so blazed last night, and it was great untill I woke up the next morning with a serious pot over.
por Chaz Castel 07 de Janeiro de 2008
When four hours into taking LSD or acid, because at this time acid is at its peak you take X
Dude, we took acid four hours ago we should totally try candy flipping and take X.
por Chaz Castel 08 de Janeiro de 2008

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A haven for the pitifully devoted portion of the FFXI community to vent their juvenile frustration over trivial occurrences in a video game, such as KS and MPK. Participants in these dramatic forum conflicts are predominantly comprised of academic failures, people with little to no social dominance and those who value pixels over reality in a somewhat similar vein to a technosexual.
Oh noes, TribeWTF KS’ed my Bubbly Bernie at 3%! To the forums!

Lordwafik based his entire life around mortifying immaterial representations of individuals by posting childish remarks on Killing Ifrit.
por Reju 28 de Dezembro de 2005
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text: 651621 1 NCGC USP1706 2013 10 3 Inhibitors of USP1/UAF1: SAR in USP1/UAF1 diubiquitin SDS-PAGE gel assay Deubiquitinating enzymes (DUBs) are a class of enzymes that can cleave isopeptide bond formed between the C-terminal carboxylate of ubiquitin and a lysine side-chain amino group on the target protein. Among them, ubiquitin specific proteases (USPs) constitute the largest DUB family. Human USPs are emerging as promising targets for pharmacological intervention because of their connection to a number of human diseases, including prostate, colon and breast cancer (1, 2), pediatric acute lymphoblastic leukemia (3), and familial cylindromatosis (4). The advantage of inhibiting USPs lies in the potential specificity of therapeutic intervention that can lead to better efficacy and reduce nonspecific side effects. In a collaboration between the University of Delaware and the NIH Chemical Genomics Center, a high-throughput screen assay was developed to screen for USP1/UAF1 inhibitors (5). This assay is a orthogonal assay that tested for activity in a USP1/UAF1 diubiquitin SDS-PAGE gel assay. NIH Chemical Genomics Center [NCGC] NIH Molecular Libraries Probe Centers Network [MLPCN] MLPCN Grant: DA030552 Assay Submitter (PI): Zhihao Zhuang, University of Delaware 1. Priolo, C., et al. (2006) The isopeptidase USP2a protects human prostate cancer from apoptosis. Cancer Res 66, 8625-8632 2. Popov, N., et al. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol 9, 765-774 3. De Pitta, C., et al. (2005) A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia. Haematologica 90, 890-898 4. Kovalenko, A., et al. (2003) The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 424, 801-805 5. Chen, J., et al. (2011) Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Bio 18(11):1390-400. The inhibition assay contains 100 nM for USP1/UAF1, 2 microM K63 linked diubiquitin, and inhibitors at varied concentrations (0.08 microM - 114 microM). The reaction was allowed for 1 hour at 37 degrees C, and quenched by the addition of Laemmli sample buffer. The reaction product was separated on a 20% denaturing SDS-PAGE gel and stained with Coomassie Blue. The intensity of the individual diubiquitin and monoubiquitin band was quantified using Quantity One 4.3.1 (Biorad, Hercules, CA). The percentage of the conversion was determined and used to calculate the reaction rate. The rate was plotted against inhibitor concentrations and fitted to determine the IC50 values using GraphPad Prism (GraphPad Software, Inc. La Jolla, CA). Compounds that show percent activity >= 60% at 11 uM are considered "active" and a score of 90 is assigned; compounds that show percent activity < 60% and <= 30% at 11 uM are considered "inconclusive" are are assigned a score of 50; compounds that show percent activity < 30% at 11 uM are considered "inactive" and a score of 10 is assigned. 504878 17558397 16951176 15996926 12917691 22118673 603478 7398 1 Percent Activity at 0.00064 uM 1 15 2 Percent Activity at 0.0032 uM 1 15 3 Percent Activity at 0.016 uM 1 15 4 Percent Activity at 0.08 uM 1 15 5 Percent Activity at 0.4 uM 1 15 6 Percent Activity at 2 uM 1 15 7 Percent Activity at 11 uM 1 15 8 Compound QC 4 254 1 USP1 protein [Homo sapiens] 118600387 1 Homo sapiens human taxon 9606 0 DA030552 2


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Tuesday, March 30, 2010

Blunt takes the lead

Missouri voters continue to be unhappy with Barack Obama and his health care plan and that's helped Roy Blunt to take the lead in the US Senate race.

Blunt is up 45-41 on Robin Carnahan, but that result probably has more to do with how the state feels about Barack Obama than it does about the candidates themselves. Voters who approve of Obama are voting for Carnahan by an 84-6 margin. Voters who disapprove of Obama are voting for Blunt 80-6. The problem for Carnahan is that a 52% majority of voters in the state fall in the disapprove column when it comes to the President compared to only 43% who think he's doing a good job.

Blunt's advantage comes thanks to a 47-35 lead with independents and also because Republicans are remarkably unified. He leads Carnahan 84-1 with his party's voters. The controversy over health care is helping to keep GOP voters on the same page, as they oppose the plan signed into law last week by a 93-1 margin. Overall 54% of voters in the state are against it with 37% in support, and 51% think Republicans should work to repeal it compared to 42% who believe the party should let it stand.

There are some warning signs for Blunt in the poll though. Only 25% of voters say they have a favorable opinion of him to 41% who view him unfavorably. Carnahan isn't all that popular either with 38% holding a positive opinion of her to 43% whose opinion is negative, but those personal favorability numbers are a lot better than Blunt's. Beyond that 55% of voters trust Jefferson City politicians most to deal with Missouri's problems compared to only 13% who pick Washington DC. Drawing a contrast between herself as someone who's worked hard in the state and Blunt as a Washington insider has the potential to pay dividends for Carnahan further down the road.

There are two ways to see Carnahan coming out on top in this race. If Obama's approval gets even just to the point where the state is equally divided in its feelings about him Carnahan will probably come out on top because of her greater personal popularity and the anti-Washington sentiments of the electorate right now. If Obama's numbers don't get any better Carnahan's going to have to try to shift the election from a referendum on the President to a referendum on Roy Blunt and his record in Washington.

This election's a great example of how important timing is in politics. 2006 or 2008 and Carnahan destroys Blunt. But in 2010 it's not going to be an easy road.

Full results here

Akshay said...
This comment has been removed by the author.
Jose said...

Unfortunately for the Dems, if things continue like they are, Blunt only has to label Carnahan as a Obama/Pelosi/Reid crony to cruise to victory

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Life Sentence Handed Down in Tulsa Man's Death

Oct 2, 2012

TULSA, Okla. (AP) — A Tulsa County judge has sentenced a man to life in prison without parole in the death of businessman Neal Sweeney.

Fred Shields was sentenced Monday for Sweeney's death. Last month, a jury convicted Shields of first-degree murder and conspiracy to commit murder for Sweeney's 2008 shooting death.

Shields received life sentences on both counts.

Prosecutors alleged that Sweeney was killed in a murder-for-hire plot, and convenience store owner Mohammed Aziz pleaded guilty earlier this year to soliciting the murder.

Prosecutors claimed that Shields helped connect Aziz with the alleged gunman, Terrico Bethel. A jury convicted Bethel in August of first-degree murder and he was sentenced to life in prison.


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Tulsa City Council Approves Budget... with changes

Tulsa, OK – The Tulsa City Council approved Mayor Dewey Bartlett's proposed budget Thursday. However, before doing so, they voted to add certain items back to the budget. Those items include restoring all highway lights, reducing firefighter pay cuts and putting the 2 Tulsa Police Department helicopters back in the air. Mayor Bartlett says his $550,000,000 budget is already stretched thin and he believes additions will create problems later. Councilors proposed several ways of transferring money into the budget to pay for the new items, including an increase in utility and sewer fees.


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Bing Bang Boing

Douglas Florian, Author
Douglas Florian, Author Harcourt Children's Books $17 (144p) ISBN 978-0-15-233770-4
Reviewed on: 10/31/1994
Release date: 11/01/1994
Florian's (Beast Feast) collection of light verse is sometimes clever, sometimes silly-and almost always off the wall. He introduces a man who ``stayed in bed/ Till mushrooms sprouted from his head''; an aunt who ``grew auntlers overnight''; and the woman from Boise whose sneakers were so ``squeaky and noisy'' that ``she set them to boil/ in sunflower oil,/ Then she jogged all the way to New Joisy.'' The jocular tone occasionally falls flat, but there are plenty of deliciously gross poems with advice about not eating caterpillars (because ``that will only make you iller'') or about navigating the school cafeteria (where ``the mere thought of lunch/ Makes [your] stomach scrunch''). The black-and-white cartoon drawings, the format and the trim size clearly recall Shel Silverstein's Where the Sidewalk Ends and Jack Prelutsky's Something BIG Has Been Here. Though Florian's verses are generally more interesting than his thick line art, he is right on target with elementary school humor, whether penning paeans to smelly socks or waxing rhapsodic about beetles for breakfast. Ages 6-up. (Nov.)
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Cynthia Rylant, Author, Mark Teague, Illustrator
Cynthia Rylant, Author, Mark Teague, Illustrator Scholastic $14.95 (48p) ISBN 978-0-590-84782-7
Reviewed on: 03/03/1997
Release date: 03/01/1997
City pig Poppleton adjusts to small-town life in this understated and roundly appealing chapter book. In ""Neighbors,"" the polite Poppleton tries to think up a polite way to say ""no thanks"" to Cherry Sue, a friendly llama who invites him to breakfast, lunch and dinner every single day. When his aggravation expresses itself as rudeness, Cherry Sue admits that she didn't know how to stop issuing invitations without hurting Poppleton's feelings, and the two become best friends. The second vignette, ""The Library,"" details Poppleton's reading ritual, which demands solitude. Finally, ""The Pill"" introduces Fillmore, a sick goat who refuses to take his pill unless Poppleton hides it in a cake, whereupon the stubborn goat eats all the other slices until he reaches the one with the medicine: "" `I can't eat that one,' he said. `It has a pill.' "" As in Rylant's other series for beginning readers (Henry and Mudge; Mr. Potter and Tabby), her concise sentences mimic the characters' good manners and wryly point up the failures of etiquette. Teague contributes fetching watercolor-and-pencil images of the pudgy pig, slender llama and dignified goat; the compositions are airier and the palette lighter than in his Pigsty or The Secret Shortcut. The end pages offer a satisfying bird's-eye view of the quaint, cozy neighborhood, with all three characters strolling the sidewalks. Ages 4-7. (Mar.)
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Logo of ecamJournal's HomeManuscript SubmissionAims and ScopeAuthor GuidelinesEditorial BoardHome
Evid Based Complement Alternat Med. 2005 June; 2(2): 223–226.
Published online 2005 April 20. doi:  10.1093/ecam/neh086
PMCID: PMC1142198

Isolation of CYP3A4 Inhibitors from the Black Cohosh (Cimicifuga racemosa)

Recent investigation on drug interaction has shown that some foods and herbal medicines increase the oral availability of a variety of CYP3A4 substrates, which is caused by the reduction of CYP3A4 in intestinal epithelium. During the course of our investigation on CYP3A4 interaction, we found that the commercially available dietary supplement made from black cohosh (Cimicifuga racemosa) showed CYP3A4 inhibition. Black cohosh has been used for the treatment of menopausal and post-menopausal symptoms as a dietary supplement. Bioassay-guided isolation from the supplement afforded six active principles, which were identified as cycloartanoid triterpene glycosides.

Keywords: black cohosh, Cimicifuga racemosa, CYP3A4, cytochrome P450, inhibition, triterpene glycoside

The rhizomes of Cimicifuga species (Ranunculaceae) are used as Traditional Chinese Medicines. Among Cimicifuga species, C. heracleifolia, C. dahurica and C. foetida are listed in the Chinese Pharmacopoeia and used as an anti-inflammatory, antipyretic and analgesic remedy (1). Cimicifuga racemosa, commonly known as black cohosh, is a herb used among Native Americans to treat a variety of ailments, including diarrhea, sore throat and rheumatism. It is best known for its health benefit in treating menopausal disorders (2). It is used therapeutically to reduce the frequency and intensity of hot flushes (3), and in the USA the extract of C. racemosa is available for sale as a dietary supplement used for the treatment of menopausal and post-menopausal symptoms (4). Cytochrome P450 (CYP) enzymes belong to heme-containing monooxygenases and constitute three families, CYP1, CYP2 and CYP3 (5), and these enzymes are recognized to be responsible for drug metabolism, carcinogenesis and degradation of xenobiotics. Among a family of CYP enzymes, CYP3A4 is the most abundant enzyme in human liver microsomes and intestinal epithelium; ~30% of the total CYP was suggested to be CYP3A4 (6), and >50% of clinically used drugs are oxidized by CYP3A4 (7,8). It is widely known that concomitant oral administration of several foods and herbs affects drug metabolism in humans by inhibiting CYP3A4 activity. Among them, the inhibition by grapefruit juice has been well studied and it is reported that concomitant intake of the juice alters the pharmacokinetics of various drugs, including cyclosporin (9,10), midazolam (11), dihydropyridine-type calcium channel blockers (12) and triazolam (13). In the course of our study on CYP inhibitors from foods, we have reported the isolation and structural elucidation of CYP inhibitors from grapefruit (Citrus paradisii) juice (1416), white pepper, Piper nigrum (17,18) and the strawberry fruit, Fragaria ananassa (19). Recently, we found that the commercially available black cohosh, C. racemosa Nutt, showed CYP3A4 inhibition. Here we report the isolation, structural identification and CYP inhibitory activity of constituents from black cohosh.

General Methods

Nuclear magnetic resonance (NMR) spectra were recorded on a JEOL GSX-500 NMR spectrometer in pyridine-d5. Mass spectra were measured on a JEOL SX-102 mass spectrometer.

Isolation of Triterpene Glycosides 1–6 from C. racemosa

Commercially available black cohosh, C. racemosa Nutt, was generously provided by from Tokiwa Phytochemical Co., Ltd. (Japan). The powder of black cohosh (20 g) was suspended in water and extracted with ethyl acetate (EtOAc). The organic layer was then partitioned between hexane and 90% methanol (MeOH)-H2O. The polar fraction (6.1 g), which exhibited significant CYP3A4 inhibition, 44% at 5 mg/ml, was subjected to silica gel chromatography with EtOAc/MeOH followed by octadecyl silica gel (ODS) chromatography with MeOH/H2O and then acetonitrile (CH3CN)/H2O to afford a potent CYP3A4 inhibitory fraction. The purification by ODS high-performance liquid chromatography (HPLC) with CH3CN/H2O gave six triterpene glycosides 1–6. On the basis of 1H NMR spectra in C5D5N and fast atom bombardment mass spectrometry (FABMS), the six triterpene glycosides were identified as cimiracemoside H (1, 2.0 mg, 0.01% yield) (19), 26-deoxyactein (2, 1.1 mg, 0.0055%) (20,21), 23-O-acetylshengmanol 3-O-β-d-xylopyranoside (3, 1.9 mg, 0.0095%) (22), actaeaepoxide 3-O-β-d-xylopyranoside (4, 1.1 mg, 0.0055%) (23), 25-O-acetylcimigenol 3-O-α-l-arabinopyranoside (5, 5.9 mg, 0.029%) (24) and 25-O-acetylcimigenol 3-O-β-d-xylopyranoside (6, 4.2 mg, 0.021%) (25,26) (Figure 1).

Figure 1
Structures of CYP inhibitors isolated from C. racemosa

Assay of CYP3A4 Inhibition

CYP3A4 activity was based on nifedipine oxidation. Various amounts (0–10 µM, final concentration) of samples in 1 ml of dimethylsulfoxide (DMSO) were added to 192 µl of solution containing 100 mM phosphate buffer (pH 7.4) containing 50 µM nifedipine (Wako Pure Chemical Industries, Ltd, Osaka, Japan), 5 mM glucose-6-phosphate (Oriental Yeast Co., Ltd, Tokyo, Japan), 0.5 mM b-NADP+ (Oriental Yeast Co., Ltd), 0.5 mM MgCl2 and 4.3 µg/ml glucose-6-phosphate dehydrogenase (Oriental Yeast Co., Ltd) and incubated at 37°C for 5 min. CYP3A4 (Gentest Co., Woburn, MA) was also pre-incubated in 7 µl of the buffer at 37°C for 5 min and added to the sample solution. After the incubation at 37°C for 1 h, the reaction was quenched by the addition of 100 ml of MeOH. After adding 3.7 µg of 6-methoxycarbonyl-5-methyl-7-(2-nitrophenyl)-4,7-dihydrofuro[3,4-b]pyridin-1-(3H)-one in 1 µl of DMSO as an internal standard, the reaction mixture was extracted with 1 ml of ether, and the ether layer was evaporated. The residue was dissolved in 100 µl of MeOH, and an aliquot (20 µl) was analyzed by reverse-phase HPLC (column, TSK-gel ODS-120T, 4.6 mm i.d. × 150 mm; mobile phase, 64% MeOH-H2O; flow rate, 1.0 ml/min; detection, UV 254 nm); retention times: 2.9 min for the internal standard, 4.0 min for the nifedipine metabolite (nifedipine pyridine) and 5.5 min for nifedipine. The IC50 value, the concentration required for 50% inhibition of CYP3A4 activity, was calculated from the data of duplicate measurements.

Bioassay-guided Isolation of Triterpene Glycosides 1–6 from C. racemosa

The CYP inhibition was tested using human CYP3A4 as shown in Methods. Commercially available supplement of C. racemosa was extracted with EtOAc, and the organic layer was then partitioned between hexane and 90% MeOH-H2O. The polar fraction exhibited significant CYP inhibition. Forty-four percent inhibition at 5 mg/ml was as potent as that by ketoconazole, 58% at 5 mg/ml. Bioassay-guided fractionation afforded six triterpene glycosides 1–6. On the basis of their 1H NMR spectra in C5D5N and FABMS, they were identified as cimiracemoside H (1, 0.01% yield) (20), 26-deoxyactein (2, 0.0055%) (21,22), 23-O-acetylshengmanol 3-O-b-d-xylopyranoside (3, 0.095%) (23), actaeaepoxide 3-O-β-d-xylopyranoside (4, 0.0055%) (24), 25-O-acetylcimigenol 3-O-α-l-arabinopyranoside (5, 0.0029%) (25) and 25-O-acetylcimigenol 3-O-β-d-xylopyranoside (6, 0.0021%) (26,27). The CYP inhibitory activities of 1–6 are shown in Table 1, which indicates moderate IC50 values.

Table 1
CYP3A4 inhibition of C. racemosa metabolites

Bailey et al. demonstrated that the blood concentration of anti-hypertensive drugs such as nifedipine was kept at a high level with grapefruit juice co-administered to mask the taste of alcohol. Since that time there has been a great deal of interest in food–drug interactions because of the clinical risks associated with changes in the bioavailability or metabolic rate of clinically administered drugs. In spite of the increasing use of herbal remedies and nutraceuticals, information on the drug interaction that occurs with them including foodstuffs, is still insufficient to understand the clinical risks.

We have studied drug interactions with foodstuffs such as grapefruit juice and pepper, isolating several potent CYP3A4 inhibitors in each material. The fact that a foodstuff contains more than one inhibitor suggests that the clinical effect of drug interaction with herbs and foodstuffs could be better understood by studying the mixture of inhibitors and/or an extract of these.

During our study on CYP3A4 inhibitors contained in food, we found that the supplement of C. racemosa exhibited potent inhibition. The polar fraction from the extract showed 44% inhibition at 5 mg/ml, which was as potent as the inhibition produced by ketoconazole, 58% at 5 µg/ml. We clarified the main constituents, cognate triterpene glycosides, as the CYP3A4 inhibitory principles. To date, highly potent CYP3A4 inhibitors in food have been reported, e.g. paradisins A and B (IC50, 0.07 and 0.07 µM) from grapefruit juice (15), dipiperamide A (IC50, 0.18 µM) from white pepper (17) and gomisin C (IC50, 0.254 µM) from Schisandra fruit (29). Although the IC50 value of each isolate was moderate, the high content of a series of cognates in the supplement could result in the exhibition of significant CYP inhibition. Care should be taken to avoid concomitant intake of black cohosh with any kind of medication because of the possibility of increasing the bioavailable concentration of drugs in the blood by the downregulation suppression of CYP3A4. Medical practitioners therefore should pay more attention in order to avoid any trouble with diet containing black cohosh.

The IC50, 0.027 mg/ml, of the extract of black cohosh was very low in spite of the weak activities of the isolated compounds. The IC50 value indicates that 40 mg of the black cohosh extract could be estimated to inhibit the metabolism of roughly half a dose of nifedipine for 1 day.

Evaluation of the IC50 of both constituents and the extract may be useful for clinical study of drug interactions of herbs and foodstuffs predicted to be a clinical risk, especially for the study of the mechanism of action and the pharmacokinetics.

The authors are grateful to Tokiwa Phytochemical Co., Ltd (Japan) for the generous gift of black cohosh.

1. New Medicinal College of Jiangsu (ed.). Shanghai: Shanghai Scientific and Technological Press; 1977. Dictionary of Chinese Materia Medica; p. 451.
2. Lieberman S. A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause. J Women's Health. 1998;7:525–29. [PubMed]
3. McKenna D, Jones K, Humphrey S, Hughes K. Black cohosh: efficacy, safety, and use in clinical and preclinical applications. Altern Ther. 2001;7:93–100. [PubMed]
4. Borrelli F, Izzo AA, Ernst E. Pharmacological effects of Cimicifuga racemosa. Life Sci. 2003;73:1215–29. [PubMed]
5. Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 1996;6:1–42. [PubMed]
6. Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerish FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther. 1994;270:414–23. [PubMed]
7. Guengerish FP. Role of cytochrome P450 enzymes in drug–drug interactions. Adv Pharmacol. 1997;43:7–35. [PubMed]
8. Rendic S, DiCarlo FJ. Human cytochrom P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab. Rev. 1997;29:413–580. [PubMed]
9. Ducharme MP, Warbasse LH, Edwards DJ. Disposition of intravenous and oral cyclosporine after administration with grapefruit juice. Clin Pharmacol Ther. 1995;57:485–91. [PubMed]
10. Yee GC, Stanley DL, Pessa LJ, Dalla CT, Beltz SE, Ruiz J. Effect of grapefruit juice on blood cyclosporin concentration. Lancet. 1995;345:955–56. [PubMed]
11. Kupferschmidt HH, Ha HR, Ziegler WH, Meier PJ, Krahenbuhl S. Interaction between grapefruit juice and midazolam in humans. Clin Pharmacol Ther. 1995;58:20–8. [PubMed]
12. Bailey DG, Arnold JM, Spence JD. Grapefruit juice and drugs. How significant is the interaction? Clin Pharmacokinet. 1994;26:91–8. [PubMed]
13. Hukkinen SK, Varhe A, Olkkola KT, Neuvonen PJ. Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice. Clin Pharmacol Ther. 1995;58:127–31. [PubMed]
14. Ohta T, Nagahashi M, Hosoi S, Tsukamoto S. Dihydroxybergamottin caproate as a potent and stable CYP3A4 inhibitor. Bioorg Med Chem. 2002;10:969–73. [PubMed]
15. Ohta T, Maruyama T, Nagahashi K, Miyamoto Y, Hosoi S, Kiuchi F, Yamazoe Y, Tsukamoto S. Paradisin C: a new CYP3A4 inhibitor from grapefruit Juice. Tetrahedron. 2002;58:6631–35.
16. Ohta T, Miyamoto Y, Maruyama T, Kiuchi F, Tsukamoto S. Localization and contents of paradisins, the most potent CYP3A4 inhibitors, in a grapefruit Citrus paradisii and grapefruit Juice. Nat Med. 2002;56:264–7.
17. Tsukamoto S, Cha B-C, Ohta T. Dipiperamides A, B, and C: bisalkaloids from the white pepper Piper nigrum inhibiting CYP3A4 activity. Tetrahedron. 2002;58:1667–71.
18. Tsukamoto S, Tomise K, Miyakawa K, Cha B-C, Abe T, Hamada Y, Hirota H, Ohta T. CYP3A4 inhibitory activity of new bisalkaloids dipiperamides D and E and cognate alkaloids from the white pepper. Bioorg Med Chem. 2002;10:2981–85. [PubMed]
19. Tsukamoto S, Tomise K, Aburatani M, Onuki H, Hirota H, Ishiharajima E, Ohta T. J Nat Prod. 11. Vol. 67. 2004. Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa Duch. cv. Tochiotome; pp. 1839–41. [PubMed]
20. Shao Y, Harris A, Wang M, Zhang H, Cordell GA, Bowman M, Lemmo E. Triterpene glucosides form Cimicifuga racemosa. J Nat Prod. 2000;63:905–10. [PubMed]
21. Koeda M, Aoki Y, Sakurai N, Nagai M. Studies on the Chinese crude drug ‘Shoma.’ IX. Three novel cycloanostanol xylosides, cimicifugosides H-1, H-2 and H-5, form Cimicifuga Rhizome. Chem Pharm Bull. 1995;43:771–6. [PubMed]
22. Chen S-N, Li W, Fabricant DS, Santarsiero BD, Mesecar A, Fitzloff JF, Fong HHS, Farnsworth NR. Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein. J Nat Prod. 2002;65:601–5. [PubMed]
23. Kusano A, Shibano M, Kitagawa S, Kusano G, Nozoe S, Fushiya S. Studies on the constituents of Cimicifuga species. XV. Two new diglycosides from the aerial parts of Cimicifuga simplex WORMSK. Chem. Pharm. Bull. 1994;42:1940–43.
24. Wende K, Mugge C, Thurow K, Schopke T, Lindequist U. Actaeaepoxide 3-O-b-d-xylopyranoside, a new cycloartane glycoside from the rhizomes of Actaea racemosa (Cimicifuga racemosa) J Nat Prod. 2001;64:986–9. [PubMed]
25. Ye W, Zhang J, Che C-T, Ye T, Zhao S. New cycloartane glycosides from Cimicifuga dahurica. Planta Med. 1999;65:770–1. [PubMed]
26. Kadota S, Li JX, Tanaka K, Namba T. Constituents of Cimicifugae rhizoma II. Isolation and Strucures of new cycloartenol triterpenoids and related compounds from Cimicifuga foetida L. Tetrahedron. 1995;51:1143–66.
27. Takemoto T, Kusano G, Kawahara M. Studies on the constituents of Cimicifuga spp. VI. Structures of 25-O-acetylcimigenoside and 25-O-methylcimigenoside. Yakugaku Zasshi. 1970;90:64–7. [PubMed]
28. Beijing: The People's Health Publishing House & The Chemical Industry Publishing House; 1990. ‘The Pharmacopoeia of Chinese People's Republic’ vol. I; p. 59.
29. Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe T. Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug Metab Dispos. 2004;32:1351–8. [PubMed]

Articles from Evidence-based Complementary and Alternative Medicine : eCAM are provided here courtesy of Hindawi Publishing Corporation


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X Window System

The X window system (commonly X Window System or X11, based on its current major version being 11) is a display server and network protocol that provides a basis for a graphical user interfaces (GUIs) and rich input device capability for networked computers. In Liunux it sits between the Operating System kernel and the Window Manger.

X is primarily a protocol and graphics primitives definition and it deliberately contains no specification for application user interface design, such as button, menu, or window title bar styles.

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Max Cavalera Talks Suicide Silence, Killer Be Killed, Soulfy + Cavalera Conspiracy

max cavalera soulfly
Kathy Flynn,

Is there anyone in rock with as many irons in the fire as Max Cavalera? In the years since his exit from Sepultura, the singer-guitarist initially focused his efforts on Soulfly before expanding his resume in recent years. The rocker has recently added Cavalera Conspiracy and now the supergroup Killer Be Killed to his “to-do” list and he’ll be busy with all three acts this year.

Loudwire had a chance to speak with Cavalera, who added making a guest cameo with Suicide Silence at the Revolver Golden Gods as part of his responsibilities for the evening, just prior to the event. Cavalera spoke about Suicide Silence, Killer Be Killed, Soulfly and Cavalera Conspiracy in the midst of our time on the Black Carpet. Check out the interview below.

So Max, here we are at the Golden Gods tonight, and you’re not just in attendance, we’re going to see you up onstage, right?

Yeah, I’m jamming with Suicide Silence. We’re doing [Sepultura's] ‘Roots.’ I just saw them on the Black Carpet. They’re back there somewhere, and we previously did it at the Mitch [Lucker] Memorial show. It was great and everyone loved it. Sepultura was one of Mitch’s favorite bands, so it’s appropriate. It’s their first [U.S.] show with their new singer Eddie [Hermida], so when they asked me if I wanted to do that, I was like, “Hell yeah.” That sounds like a great, great plan.

That Mitch Lucker Memorial show was great, and such an amazing turnout and lineup. Can you tell me what it was like for you to be part of that event?

It was great energy, great energy. It was very emotional for me cause I gave his dad a guitar. I made ESP give me one of my guitars that I could give to his dad cause I knew that his dad was a big part of bringing him up on metal. And I found out from secret sources that ‘Chaos A.D.’ was Mitch’s second album. Deftones was his first. So his dad did a good education on the kid, you know.

I never met Mitch unfortunately. We had always toured separately, but it was great to be invited and it was a special, special night. You could feel it in the air and there were so many singers from so many cool bands, especially a lot of newer bands that I really like — Whitechapel was there and All Shall Perish — so it was really cool and I was one of the old guys [laughs].

You’ve got so many projects. Let’s start with Killer Be Killed, since that’s next up for you. How did you get involved with that?

Yeah, that was actually Greg [Puciato]‘s idea. I was not looking for a project. I’ve got Soulfly and Cavalera Conspiracy and I’m very busy, but Greg was very persistent. He was like, “We’ve got to do it. We’ve got to do this project,” and I told him, “We can do it, but it’s gotta be different.” And it was. We got together and made a really special record I think — especially with the voices. You’ve got Greg’s voice, my voice, Troy’s [Sanders] voice. It’s a collision, man. It’s really, really weird. But it works and it doesn’t sound like our own bands, so that’s a good thing.

With a supergroup, even though everyone’s solid, there’s no guarantee that it will work. What was it like getting together with these guys and how soon did you know it was going to work out?

Well it went through phases. It started out as just this really punk think with me and Greg. We wrote the first demos and it sounded like s—. Just total, total s—. We played it for people and they told us, “Do not play this for people if you want to get signed.” So we kept those demos hidden and I don’t know if I’d ever want to release them. But it got better as we got more players. We got Dave Elitch, who is a killer player and a killer drummer and then when Troy joined the band, it just became really powerful and really great.

And how about Soulfly at this point?

Soulfly’s touring. We’re going to Russia with the Korn guys. We’ve got 10 shows. It’s going to be awesome, going all over Siberia and flying with them. It’s going to be fun and I’ve got some pranks all ready. I’m going to prank them. [Laughs] You know, maybe a couple of shaven heads.

Hear that, Korn? Don’t fall asleep!

Right, right.

Also, Cavalera Conspiracy. I know you’ve been working on that as well.

Yeah f— the groove. That’s what we’re going to call it, cause it’s all fast and brutal. I made my brother sweat. It’s like trying to make him play fast like he’s 15-years-old. I don’t care if you’re 43, I don’t give a s—. You’re gonna play fast the whole time and every time he was in a groove, I’d say, “F— the groove. Get out of the groove and go back to fast.” So maybe we call [the new album] ‘F— the Groove.’

Here at the Golden Gods, obviously you’re playing with Suicide Silence, but anyone else you’re excited to see play?

Well, I’m not too big on Guns N’ Roses, but I like Duff [McKagan]. Duff’s a good guy and I heard he’s going to play with them, so that should be fun. And, of course, I’m looking forward to Suicide Silence.

Our thanks to Max Cavalera for the interview. Killer Be Killed’s debut disc can be pre-ordered here ahead of its May 13 release. Soulfly’s tour dates can be seen here.

See the Killer Be Killed Debut Album Details

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Adventure and Disaster; THE TEXAN-SANTA FE PIONEERS. By Noel M. Loomis. Illustrated. 329 pp. Norman: University of Oklahoma Press. $5.

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BY June, 1841, the Republic of Texas was in serious trouble. Faced with bankruptcy, vengeful neighbors to the south and hostile Indians to the north and west, President Mirabeau B. Lamar looked for some means of propping up his administration.

March 16, 1958

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Director General BARETT of the Pan-American Union has prepared a special report on Pan-American trade in view of the opening of the Panama Canal. The Pan-American Union is an international organization for the development of commerce among the nations ell America. Mr. BARRETT, as is well known, keeps in close touch with the trade situation in North and South America.

September 20, 1912

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CHICAGO, April 24 -- The American League season was formally opened here to-day with decorations, music, and the hoisting of the championship pennant. Hoffer's wildness at the start gave the champions their first game. Bradley, Shugart, and both outfields did sensational fielding. Score:

April 25, 1901

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The airport men's room where Senator Larry E. Craig was arrested here in a police sting operation is in one of the busiest areas of the Minneapolis-St. Paul International Airport, at the intersection of five concourses and near a bustling mall and food court.

Mr. Craig passed through the terminal regularly as he traveled between his home district in Boise, Idaho, and his Congressional offices in Washington.

The details of his arrest shocked his colleagues and constituents, but he was not the only person ensnarled in the airport police enforcement action against what the authorities said was lewd conduct in the restroom. Thirty-nine other men were arrested here in a three-month period this summer.

A review of their cases and interviews with four lawyers representing many of the accused show how Mr. Craig -- who pleaded guilty to disorderly conduct but now says he is innocent -- fits into the larger picture of the sting operation, and sheds light on his prospects in court should he be allowed to withdraw his guilty plea.

Police and court files indicate that Mr. Craig's case may have been handled more harshly than some of the others. For instance, he alone among the 40 men arrested was charged with both disorderly conduct and interference with privacy. The other men were charged with one or the other, or with indecent exposure or loitering.

Patrick Hogan, a spokesman for the airport and the law firm it hired to prosecute the cases, said Mr. Craig was the only man charged with two offenses because he had peered into the police officer's stall and had used unspoken signals -- foot tapping and hand motions -- known as ways to solicit restroom sex.

Mr. Craig, who says he is not gay, said his actions were misinterpreted by the arresting officer.

Lawyers for many of the other 39 men said that they were contesting the charges against their clients, and that Mr. Craig, too, could have mounted a vigorous defense if he had hired a lawyer instead of plea-bargaining.

The lawyers said their defense strategies were based on the conduct of the police, the lack of sexual contact in the cases and the airport police's novel use of a privacy law as the basis of the most serious charge made against their clients.

Mr. Craig was one of 20 of the men who were charged with interference with privacy, a gross misdemeanor; the penalty is up to a year in jail. But the defense lawyers said the law, adopted two years ago in response to cases involving hidden cameras in women's rooms, had not been used before in a sex sting operation.

Jeffrey Dean, a lawyer defending four of the men, said: ''There can be no invasion of privacy of a person who is inviting the conduct. The undercover officer, by his own account, sits there in an adjacent stall and signals the person that he wants this contact.''

The disorderly conduct charge to which Mr. Craig pleaded guilty is a lesser offense with a suspended sentence, $500 fine and probation. Ten of the 40 men arrested in the restroom have pleaded guilty to various charges. No trials have been scheduled, and none of the men have had charges dismissed, although two were given ''suspended prosecution'' in which their records may be expunged after a year.

Robert J. Shane, a lawyer for a man who received a suspended prosecution, said, ''If Craig would have had an attorney, I think he could have got that type of agreement.''

Jerome A. Burg, a lawyer for another defendant, said after reviewing Mr. Craig's publicly available police reports: ''I don't think he had violated the law yet. I think the officer jumped the gun.'' Mr. Craig's conduct, as described in the police report, was far from the most lewd, a comparison of the 40 arrest reports showed; some men were accused of passing sexually explicit notes or exposing themselves.

His was one of only five of the cases in which a plainclothes officer was touched; Mr. Craig was accused of moving his right foot under the stall divider to touch the officer's left foot. Mr. Craig has said he may have accidentally touched shoes because he sat with his legs spread wide.

The police reports showed that many of the other men also looked into the adjoining stall, two by peering over the partition, which is less than six feet tall, and at least 14 by crouching on the floor and looking under the partition, which is one foot off the floor.

Mr. Hogan said the airport planned to replace the partitions with ones that go lower.

The Minneapolis airport is the world's 15th busiest, and is known in some circles as a site for homosexual hook-ups. ''A busy place for lewd conduct,'' a lot more than other airports, one of the men told the police after he was arrested. Another man said he had had a lot of sex with pilots and flight attendants there.

The large, gray-and-blue tiled bathroom is divided by walls into three sections for sinks, urinals and, in the back, nine small stalls. Police action there started May 13 with the arrest of a 40-year-old California man who had advertised on for ''no-strings fun while I'm waiting at the airport.'' He exposed himself, the police said, and was charged with disorderly conduct.

After that, the plainclothes police officers began sitting in the stalls to see who would solicit sex. The first arrest in their sting operation was on May 31; the operation continued until Aug. 13.

Mr. Craig's actions on June 11, as described by the police, were less blatant than those of some men with lesser charges.

For instance, a Wisconsin man, 49, had signaled an officer to enter an adjacent stall, tapped his foot, reached under the divider to touch the officer's leg and looked over the divider. He was charged with interference with privacy.

A Wyoming man, 45, exposed himself in addition to other actions, and told the police he had had sex there before. But he was charged only with the minor misdemeanor, disorderly conduct.

Three lawyers for other defendants said they were impressed with Mr. Craig's unbending denial in an eight-minute interview he had with the police shortly after his arrest. The audio was released to the news media and is on the Internet.

Mr. Burg said Mr. Craig was ''tenacious'' and ''straightforwardly defending himself'' in the interview.

''He stuck very close to his story,'' Mr. Burg said. ''A lot of people would have caved.''

Mr. Craig has said he intends to resign his Senate seat by Sept. 30 unless he can have the case overturned and gain support in Washington. If he resigns, he will join two other defendants in the sex sting who quickly lost their jobs: a 21-year-old airport store worker and a 25-year-old US Airways employee, whose employers learned of the arrests when police seized and later returned their airport security badges. Both men admitted to previous sexual contacts in the restroom.

Mr. Dean, the defense lawyer, said, ''My legal argument is: as long as it's not invading anybody else's privacy, as long as it's not causing alarm to other people in the bathroom, and as long as they don't actually have sex in the bathroom, it's no crime.''

Jonathan Burris, a lawyer representing five of the defendants, said the national attention on Mr. Craig had made prosecutors less likely to reduce charges against the other men.

''They're very happy with their officers for their wonderful sting they've put together,'' Mr. Burris said, adding, ''This is an airport -- they're supposed to watch out for terrorists and bombs, not sit in a bathroom eight hours a day.''

PHOTO: Arrests were made in a sting at the Minneapolis-St. Paul airport from May 31 to Aug. 13. Plainclothes officers arrested airport workers, a senator and others accused of soliciting sex.(PHOTOGRAPH BY BEN GARVIN FOR THE NEW YORK TIMES)
CHART: Arrests in Airport: This summer, a sex sting conducted in the men's room at the Minneapolis-St. Paul International Airport by airport police resulted in the arrests of 40 men, including Senator Larry E. Craig, Republican of Idaho. Here are the 40 cases, with their charges and their dispositions. Some are still pending.