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Financial Advice About Why You Need a 401(k) Plan

When someone suggested I work in the stock market about 20 years ago, I laughed in their face. It was the mid ‘90s and I had just sold my caffeinated water company, Krank2o. My experience laid in entrepreneurship and small businesses, leading me to believe there was no place for me in the stock market. Well, I was wrong. There was a place for me and it was in the world of 401(k)s.

Now, you may think, what's a creative guy like me doing in 401(k)s? But it was a good fit for me; I was going into smaller businesses like the ones I got my start in and teaching the employees about their options for their future. I was making positive changes in their lives. I liked helping people prepare for their retirement, and I was good at it. Stockbroking was fun but retirement investing felt like a more long-term way to help people.

My newfound passion led me to start Social(k), the first 401(k) platform to offer more than a few socially responsible funds. We offer about 500 screened, socially responsible options, and more than 5,000 traditional funds. I saw an opportunity to take the relatively sustainable personal investment that is a retirement plan and make it sustainable for the global community as well. Why not make that mass of slow money work for the world, as well as the investors?

As the president of Social(k) I spend a lot of time talking to employees and employers about why 401(k)s matter, and the number of people who believe they don’t need to prepare for the future is shocking. Part of my job is to help you see why you should, so that when the time comes, you can enjoy retirement with one less thing to worry about.

Here are three reasons why you should have a 401(k).

1.   You owe it to yourself.
You have to take personal responsibility for yourself. If you think you are going to live a long and healthy life, you owe it to yourself, your family and society to prepare for that. You may believe your expensive cars and valuable real estate will see you through, but those markets can crash, and you want to have savings elsewhere in case that happens. Why not put some of the money you’ve worked so hard to earn into a tax-sheltered place? Which brings me to my second reason…

2.   The government really wants you to.
The government wants you to put money away for retirement so badly that they will give you tax incentives. An example is the pre-tax incentive. This occurs when you put a certain amount of your earnings into your 401(k), and the government does not tax you for that part of your earnings. At that time, you only have to pay tax on the portion of your earnings that does not go into your 401(k). They will not tax the rest of the money until you are ready to take it out of your 401(k), and the theory is that when you take it out, you will be retired and earning less money, so you are at a lower tax bracket. Not a bad deal, is it? The Roth IRA post-tax option is even sweeter. Put the money in after taxes are paid and all earnings come out tax-free!

3.   It's free money.
The best part about having a 401(k) is that it grows. When you’ve retired, the money you put into your 401(k) will almost certainly have increased in value. Yes, I’m saying you get free money. For example, you put in $50,000 and now the fund is worth $150,000. Need I say more?

My question for you now is, after reading this, do you still have qualms about investing in a 401(k)? And if so, why? Leave your answer in the comments below to be addressed in a future story.

Stay tuned for a five-part series on “fossil-free” investing brought to you by the fund managers helping you prepare for retirement.

Robert Thomas is a member of the DailyWorth Connect program. Read more about the program here.

Join the Discussion


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The Twilight Saga: Breaking Dawn, Part 2, pictured — the finally film in the chastely sexy vampires-versus-werewolves series, opens Friday. Like Part 1, it is directed by the Oscar-winning gay scribe and director Bill Condon, who gave weight to Frankenstein filmmaker James Whale in Gods & Monsters. Also opening Friday is the foreign-language period romance A Royal Affair. And opening Wednesday: Silver Lining Playbook, a romantic comedy about mental illness starring Bradley Cooper and Jennifer Lawrence; and the Cold War action remake Red Dawn.

— A.W.J.

This article appeared in the Dallas Voice print edition November 16, 2012.

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Become a select member of the Damn Fine Bacon Club, or what we’re calling the Damn Fine Bacon CSB (“Connoisseurs of Select Bacon”)!

We are going on an indefinite hiatus as of January, 2018.

If you want to add on to your current subscription, now is the time to do it – you can add on additional pounds below plus we have Black Back Bacon!!!

Imagine getting as much bacon as you NEED! All you have to do is join the club. Once you’re a member, I will cure, smoke and package your bacon for you—then, like a box of produce from your CSA farm, you just pick it up!

You can join for three ($42), six ($84), or nine ($126) months at a time.  The pick up point in San Francisco is at SUCCULENCE in Bernal Heights on the first Saturday of every month. It’s a great shop with succulent plants as well as a range of homesteading supplies.

We also have two East Bay locations! You East Bay People can get that Damn Fine Bacon fix without having to slog over to the chilly microclimates of the West Bay. They’re also on the first Saturday of the month.

One’s at a front porch of an old friend who lives on 60th, between Telegraph and Claremont, in Oakland.

The second one’s an Alameda pickup spot. Get your bacon without leaving the island! An enterprising club member has brought Damn Fine Bacon to her porch.

In Marin, the pickup location is on Juanita Ave. in Mill Valley.  It’s at the home of my partner-in-pig.

Every month you’ll be able to add on to your standard delivery of a pound of sliced bacon. As I make new varieties of bacon, you’ll get preview samples. If you want to throw a bacon-centric party or some other gloriously indulgent event that cries out for bacon, as a member and with enough of a heads-up, we can help make this happen!

Is one pound a month not enough? You can sign up for as many memberships as you want—you’ll get more gifts that way, too!

For members who aren’t able to make a monthly commitment, we now offer one-time pickups. You still have to be a member and you still pick up on the first Saturday of every month. This is also the way to add on to your monthly subscription—extra bacon, a jar of oil, special items, etc.

Get Yer Bacon!


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It's been rumored for a few months, but on Monday morning, Intel made it official: it is purchasing the Wireless Solutions (WLS) business unit from Infineon Technologies for $1.4 billion.

The purchase gives Intel a one-stop semiconductor offering in its quest to take mobile market share. The company has openly expressed its intentions to target the mobile market with its new Atom processor.

Infineon makes the baseband and RF transceiver chips used in a wide variety of cell phones, most notably the Apple iPhone. It's also used by Nokia, Ericsson, LG and Samsung.

Between the Infineon chips and Atom CPU, that's most of the silicon internals you need to make a cellular phone. All you need at that point is memory, which Intel makes, plus other pieces like power amplifiers, a motherboard, a battery, a screen and a case.

The deal is valued at $1.4 billion and will have to go through the usual regulatory approval in the U.S. and Europe. The two firms said they expect the deal to close in the first quarter of 2011. Intel said the wireless unit will operate as an independent unit in its native Germany, where Infineon is headquartered.

"The global demand for wireless solutions continues to grow at an extraordinary rate," Paul Otellini, Intel president and CEO, said in a statement. "The acquisition of Infineon's WLS business strengthens the second pillar of our computing strategy -- Internet connectivity -- and enables us to offer a portfolio of products that covers the full range of wireless options from Wi-Fi and 3G to WiMAX and LTE. As more devices compute and connect to the Internet, we are committed to positioning Intel to take advantage of the growth potential in every computing segment, from laptops to handhelds and beyond."

Maybe the second time in the mobile signaling market will be the charm for Intel. It purchased DSP Communications for in 1989 $1.6 billion, but the business failed to catch fire. Intel took $600 million in write-downs before selling the business off to Marvell Communications in 2006 for just $600 million.

Infineon, for its part, loses about 30 percent of its revenue, but the wireless business was its smallest business. In announcing the deal, CEO Peter Bauer said the company plans to focus on those market segments now that it has divested the wireless business. Infineon has a much bigger interest in multimedia, chip card and security, and the automotive industry. Automotive is its largest business. The company even owns a race track in northern California called Infineon Raceway .

Buying Infineon makes for a decent revenue stream, but the real benefit is the technology Intel has gained, said semiconductor analyst Nathan Brookwood of Insight 64.

"Ultimately, Intel needs to integrate these kinds of baseband capabilities onto SoCs (systems on a chip) with Atom, and trying to develop this kind of technology from scratch is very hard," he said.

"It makes even more sense when you consider they needed this technology to expand their offerings. Infineon is in the LTE market while Intel was in WiMax. What's not to like?"

LTE , or Long-Term Evolution, is the next generation in high-speed wireless, with a focus on data rates. Data transfer rates over LTE can theoretically reach 100 gigabits per second but are usually lower than that. Initial LTE tests by Verizon Wireless have put LTE in the 40 to 50 Gbps range, which is faster than the fastest cable modem.

Intel has been a big supporter of WiMax , another high-speed wireless solution that's supported by Sprint in the U.S. but has much wider adoption outside of the U.S. Within the U.S., all four major carriers have said they would support LTE but only Sprint is carrying WiMax.

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Ramzi and his lovely family contacted me when they received one of my vouchers through Woodford and Co estate agents. The voucher entitled them to a free family portrait session and a free photographic print as a thank you for using Woodford. Since the spelling of Ramzi was obviously quite exotic I did what I always do and asked about his ancestry. It's one of the ways I can tick countries off my ManKIND project. I was delighted when he said he was Palestinian as I had expected that to be one of the trickier ones to tick off.

They loved all their family portraits so much they invested in them all, so it was hard for me to add anything extra, especially as the session had been free too! So, I decided to create an audio visual presentation of all their images for them. You can check it out here
I was particularly touched when Ramzi's wife Anna sent me this wonderful testimonial:

"Thank you, Dan, not only for taking some beautiful photographs of our family, but also for taking such trouble to find out what we were looking for and putting us at our ease. Most of all, thank you for what you are trying to do in your ManKIND project and for including Ramzi in that."
Anna Freij, Oundle


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What does united states congress mean?

Definitions for united states congress

Here are all the possible meanings and translations of the word united states congress.

Princeton's WordNet

  1. Congress, United States Congress, U.S. Congress, US Congress(noun)

    the legislature of the United States government

  1. United States Congress

    The United States Congress is the bicameral legislature of the federal government of the United States consisting of two houses: the lower house known as the House of Representatives and the upper house known as the Senate. Congress meets in the Capitol in Washington, D.C. Both representatives and senators are chosen through direct election. Congress has a total of 535 voting members: 435 members in the House of Representatives and 100 members in the Senate. Members of the House of Representatives serve two-year terms representing the people of a district. Congressional districts are apportioned to states by population using the United States Census results, each state in the union having at least one representative in the House of Representatives. Regardless of population, each of the 50 states has two senators; the 100 senators each serve a six-year term. The terms are staggered so every two years approximately one-third of the Senate is up for election. Each staggered group of one-third of the senators are called 'classes'. No state of the United States has two senators from the same class. Most incumbents seek re-election, and their historical likelihood of winning subsequent elections exceeds 90 percent. At three times since 2011, a Gallup poll reported that Congress’s approval rating amongst Americans was 10%, meaning that only 1 in 10 Americans had a great deal or quite a lot of confidence in the institution.

  1. Chaldean Numerology

    The numerical value of united states congress in Chaldean Numerology is: 4

  2. Pythagorean Numerology

    The numerical value of united states congress in Pythagorean Numerology is: 5

Sample Sentences & Example Usage

  1. Ron Johnson:

    I think the United States Congress should have that exact same input into the process.

  2. Ted Cruz:

    I call upon the United States Congress right now, today, to stand up and lead to defund Planned Parenthood.

  3. Secretary Sylvia Burwell:

    If the court makes the decision that we don't have the authority to do these subsidies, then the critical decisions are going to sit with the United States Congress, and with states and governors, we will do all that we can to work with them.

  4. Gabriel Silva:

    As Colombia's Ambassador to the United States during the free trade agreement's ratification in the United States Congress, I saw no evidence that any part of the treaty was impacted by any contribution made to the Clinton Foundation or any other group in the United States.

  5. House Speaker John Boehner:

    The president's national security adviser says that it's destructive for the prime minister of Israel to address the United States Congress next week. I couldn't disagree more, the American people, and both parties in Congress, have always stood with Israel. Nothing and no one should get in the way of that.

Images & Illustrations of united states congress

  1. united states congress

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Recurring gifts help make donating easy by automating the process, eliminating the need to remind yourself to give! It is also a great way to help Delta Sigma Phi by providing steady, reliable funding for students through a monthly, quarterly or annual gift to the Foundation.

How It Works

You determine the amount and frequency of your donation. We will charge your gift to your credit card, debit card or bank account at the predetermined interval (charges are made on or around the same date each period). We will send you an email confirmation of the charge. Then we will send you an annual statement that can be used for tax purposes. Your gift will automatically renew each year. It’s simple, secure and one of the easiest ways that you can support Delta Sigma Phi!

How to Sign Up

When using our online donation form, simply mark if you want to make the donation a recurring gift. You can also fill out the Direct Payment Plan Authorization Form (NOCHEX), for gifts made through your bank account. By utilizing this method and having the donation run through your bank account, you can avoid pesky credit card fees and ever changing expiration dates.

After you have signed up, you can cancel or alter your gift any time by calling us at (317) 634-1899 or emailing

The Impact of Recurring Gifts

Recurring gifts provide the Foundation with a steady flow of income used to help the Fraternity fulfill its educational mission. No matter the time of year, there are always important Fraternity programs that need funding.

Did you know?

  • $50 per month provides training for one student to attend the Presidents’ Academy.
  • $35 per month provides a Regional Leadership Academy for 12 Brothers.
  • $18.99 per month provides tuition for one student to attend The Bruce J. Loewenberg Summit.


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1 of 11
Ben Brewer, Deseret News
Salt Lake County Mayor Peter Corroon, right, looks on as he is honored by the refugee community for his work on behalf of refugees at the Salt Lake County Government Center on Tuesday, Dec. 4, 2012.

SALT LAKE CITY — Representatives of Utah's refugee community hosted a surprise party for Salt Lake County Mayor Peter Corroon on Tuesday afternoon to thank him for his support of refugee services.

But the party was temporarily delayed while Corroon participated in a job interview. His second term as mayor ends in December. He did not seek re-election.

"It was going so well, I didn't think I should stop," he said. Corroon would not say who was interviewing him, explaining, "I don't want to jinx it."

The recognition ceremony, conducted in the chambers of the Salt Lake County Council, was attended by refugees and representatives of government and nonprofit agencies that serve them.

Gerald Brown, director of the state Refugee Services Office, said Corroon is held in high regard among refugees, nonprofit and government service providers for his efforts to revamp refugee services in Utah.

"I just want to say thank you from the bottom of hearts. You have made a tremendous difference for a lot of poor people in Utah," Brown said.

In 2006, Corroon and then-Gov. Jon Huntsman Jr. co-chaired a refugee working group to identify gaps in the state's refugee resettlement system and to address other issues of concern to community advocates, starting with a series of public hearings.

The effort resulted in greater coordination of refugee services, creation of the State Refugee Office, a refugee advisory board and changes to state law to allow the use of private funds to provide training to refugee organizations and to provide grants for refugee services. The effort also helped secure new funding streams for services.

"He listens and he does stuff. Every time we've gone to him with our requests, he's responded. That's huge," Brown said in an interview earlier in the day.

When Corroon asked advocates specifically how Salt Lake County could be a better partner in refugee services, they said, "hire someone to be a liaison."

"He did," Brown said. "He hired ZeMin Xiao, and she's been outstanding."

Patrick Poulin, resettlement director for the International Rescue Committee's Salt Lake office, said Corroon has been instrumental in buttressing government support for resettlement efforts.

"He is what I call a true public servant," Poulin said. "He deserves that mantle. We sure could use a lot more people like him in government."

Aden Batar, refugee resettlement director for Catholic Community Services of Utah, said Corroon has been instrumental in reforming resettlement practices and forming partnerships between nonprofit and government entities.

"I consider him a friend to the refugee," Batar said.

Some 25,000 refugees have resettled in Utah since the end of the Vietnam War. All but about 200 live in Salt Lake County. About 1,100 refugees, many of them Bhutanese, Karen and Somali, are expected to resettle in Utah during the 2013 fiscal year, which began Oct. 1.

E-mail: marjorie@desnews.com


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Protect your home with gargoyles who enchant with the time-tested, impish charm of their Medieval ancestors who perched atop European rooftops while their Dragon companions threaten to slay unwelcome guests with their traditional, fire-breathing power. Like those found guarding ancient castles and cathedrals, our fiercely handsome Gargoyle and Dragon Statues are uniquely designed to bring a touch of old-world mystique to your outdoor living spaces.

Gargoyle & Dragon Statues

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23 September 2004

BEC aims for higher grade with Taxi

Taxi Studio has created a brand identity for Brislington Enterprise College, as the Bristol secondary school moves to challenge its reputation for academic underperformance. The branding initiative,worth a five-figure fee,

UK Gear spring in the Army’s step

The British Army has made its first incursion into consumer products putting its name and expertise to a high performance training shoe, designed and marketed by sportswear company UK Gear.

Alessandro Mendini at Alessi: A Retrospective, from 17 to 30 September, features the work of this contemporary designer, including the Proust armchair. Venue: Alessi, 22 Brook Street, London W1. From

Vodafone calls on Fitch London

Fitch London is developing a new-look retail concept for Vodafone UK’s flagship store on London’s Oxford Street. The overhaul, due to be completed in early 2005, comes in the midst

The Design Business Association will run Value of Design seminars in London, Birmingham, Bristol and Edinburgh in October. Tickets are £40. Info: Call 020 7251 9229 or e-mail hannah.paterson@dba.org.uk

CPB identifies Henley Centre

Coley Porter Bell has provided an overhaul of the visual identity for market research company The Henley Centre. As part of the rebrand the company has shortened its name to

Design Corp turns high street on to Harmony

Licensed sex shop brand Harmony’s controversial Oxford Street flagship in London is set to open, with design by start-up consortium Design Corp. An affiliation consisting of retail design specialist Spacecraft

Studioilse unveil product designs

Studioilse, the design group set up by interiors star Ilse Crawford, will unveil its first ever product designs next week at the Gainsborough Studios in north London. The collection, dubbed

Latest articles


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6 January 2000

Lashko quits design partnership

Martin McLoughlin will continue to run graphics and branding group Lashko McLoughlin following the departure of founding partner Marita Lashko for family reasons at the end of last year. Lashko,

KSDP Group has appointed Richard B Roolvink as managing director of its Amstersdam office, with effect from 1 January.

Delayed COI roster unveiled for New Year

The Central Office of Information has invited several design consultancies to appear on its first branding roster, which aims to address the organisation’s branding issues and improve the image of

On the ball

Rod Petrie could have played football for a living. Fortunately, he thinks the rules of the game will also work in the design studio

Landor rebrands JAS Indonesian airport handling services group Jasa Angkasa Semesta has been rebranded by the Hong Kong office of Landor Associates.

Latest articles


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Welcome Guest

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Posted : Thursday, December 21, 2017 8:54:51 PM(UTC)
Joined: 11/13/2017(UTC)
Posts: 1
Location: Kansas City

I want to set up IP Phone camera in my parking area and monitor it from my PC. I would also like to have a clear view of objects that are far away. Is there any way to do this with your app?
DeskShare - Support
Posted : Friday, December 22, 2017 2:03:17 AM(UTC)
DeskShare - Support

Rank: Administration

Joined: 2/27/2004(UTC)
Posts: 1,811

Was thanked: 30 time(s) in 26 post(s)

IP Phone Camera is designed to let you view your mobile device's camera on your PC. You can use the Zoom in feature to view the objects clearly.

To connect your mobile device to your PC, both devices should be on the same network.

To establish connection, first open IP Phone Camera and press START on the home screen. You will see a URL on the top of the screen, write down the URL.

Next, on your PC open a browser and enter the noted URL. You should now see the parking area view in the browser. Click on the Zoom in (+) option to see the objects that are far away clearly. You can use Zoom out (-) to get back to the original view.

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Video Edit Magic 4.47

Inserting videos into PowerPoint

Many PowerPoint presentations include graphics, sounds and PowerPoint's built-in animation.  However, effectively adding video clips to a presentation can really make it stand out.  This article explains how to use Video Edit Magic to create videos to use in PowerPoint.

Tips for creating good PowerPoint presentations

  • Be sure each slide contributes toward the primary point of your presentation.  Shorter presentations are more understandable and more memorable, so if a slide isn't adding something important to the main thrust, either remove it or move it to the background materials.
  • If the PowerPoint show is meant for unattended viewing (the viewer watches it with no speaker present) use voice narration.  Video Edit Magic lets you illustrate and discuss concepts using selected images and your own voice.
  • Unique presentations get the attention they deserve, so think of innovative presentation techniques.  For example, have a "mascot" cartoon character, doing the actions the presentation talks about, and "saying" some of the text in word balloons.  Presentations should reflect your personal (or corporate) style.
  • Graphics and photographs are self explanatory and focus the audience's attention.  Illustrating points can let you eliminate many words from the slides, and text-heavy presentations can lose the audience.  With Video Edit Magic you can Take Snaps from video footage, and use the still pictures to illustrate your presentation.

Why is Windows Media format used for PowerPoint?

Microsoft's Windows Media Video (WMV) gives high quality playback.  It also requires less processor overhead, which means smoother playback on older PCs.

The movie should have the same aspect ratio as a PowerPoint slide, or it will appear distorted or stretched when it is played.  Most PowerPoint slide shows have an aspect ratio of 4:3; so we recommend that you save your movie at 640 x 480 resolution, which has the same aspect ratio.

Creating videos for PowerPoint

The editing process in Video Edit Magic begins with importing video files from a PC’s hard drive or capturing footage from a camcorder.  To create your movie, drag the video clips onto the video tracks.  The software has two video tracks, and you can place videos on both of them.

If a video clip has sound, when you add it to a video track, a corresponding audio clip will be placed on the audio track.  If you want to replace the original audio track with narration of your own, click on the audio track and press the Del key.  Connect a microphone to your PC. Select Narration from the Tools menu.  Position the Seek Slider on the timeline where you want to start narrating, and click Record.  You can watch the video play in the Preview window and time your narration to match what you see.

Video Edit Magic avails you with an array of video effects and transitions which can be used to enhance your movies. To see how videos look after applying transitions, read our Applying Transitions Correctly article.

When you finish editing your videos, use Video Edit Magic's Make Movie Wizard (on the File menu).  This wizard enables you to choose a video or audio file format for your movie.  Select Windows Media Format (WMV) and click on Next.  The Windows Media Format Properties page appears.  On this page select DVD quality video (2 Mbps CBR) from the Video drop-down list.  This encodes the video at a bit rate of 2Mbps and a resolution of 640 X 480, which is ideal for PowerPoint.

Inserting into PowerPoint

Video Edit Magic - Insert Videos into PowerPoint
  1. Open your PowerPoint presentation and go to the slide you want the video clip to play.
  2. On the Insert menu, point to Movies and Sounds, and then click Movie from File.  Choose the video you want to use and then click OK.
PowerPoint does not include the video in the actual presentation file (.PPT).  It only creates a link.  It's a good idea to put the movie file in the same folder as your PowerPoint presentation.  If you later move the PowerPoint presentation to another PC or folder, copy the movie too.  Keeping your movie in the same folder as your presentation guarantees that the link will still work.  If you plan on distributing copies of your presentation, you should consider using the Package for CD command on the PowerPoint File menu.

Trouble Shooting

  1. If your video doesn't run smoothly, try turning your hardware acceleration down.  If you use Windows 2000 or XP, then right-click the Windows desktop and choose Properties.  Switch to the Settings tab, and click the Advanced button.  Finally, click on the Troubleshoot tab and move the slider to the left.
  2. If your movie does not play, or a blank box appears on the slide where you inserted the media file, rename the movie so that the filename and the full path to it (all the folders and subfolders) are less than 128 characters long.
  3. It is always recommended to have the latest version of DirectX and Windows Media player on the presentation PC.
    Adding video clips to your presentations can really help you stand out from the crowd.  Be outstanding—use Video Edit Magic and move beyond routine slideshows today.

Copyright © DeskShare Incorporated.  All rights reserved.


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I gang

Cricket Bat Sticker Design - repost

We need someone to design us Stickets for Cricket Bat.

Sticker Dimensions as follows:

9" x 4" for Face

14" x 4.5" for Back

4" x 4" for Bottom.

Only bid if you have delivered something like this previously. Also attach samples of your work, any bids without samples will NOT be considered at all!

NOTE: If you have NOT done a similar job before and still want to bid on the project, please create any mock for a 14" x 4.5" and attach with your bid.

Færdigheder: Koncept Design, Grafisk Design, Logo Design, Photoshop, Photoshop Design

Se mere: cricket bat sticker dimensions, sticker graphic design, logo design face, graphic sticker design, face logo design, design logo sticker, cricket bat logo design, cricket bat logo, create sticker logo, create logo dimensions, create face logo, need someone to design logo, graphic design face, sticker, sticker design, design sticker, design a sticker project, cricket, bat sticker, graphic sticker, sticker design bat, design cricket, cricket sticker design, bat sticker design, graphic design cricket

Om arbejdsgiveren:
( 0 bedømmelser ) colombo, Sri Lanka

Projekt-ID: #4116492

1 freelancer is bidding on average $850 for this job

Dear Sir, More than 6 years experience of any type of graphics job, please PM me,so that we can go ahead for the next step. Waiting here for your response :-) Kindly Regards, Nier S

$850 USD in 3 dage
(133 bedømmelser)


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I gang

CSS/Tableless template help

I have recently converted my links website to be totally css-driven (no tables). However, there are a few areas that I need help finishing as I am not a CSS expert.

My site is altsearch [dot] com. There are three main problem areas:

1. Sub Categories - If you drill down to any of the category pages, the list of sub categories has problems. Try a cat like "community" and you will see that the top two links can be clicked, but not the rest. Also, the hyperlink indicator is a bit high.

2. Link sort element - On pages that have a lot of sub categories, the Link element does not sit inline. The community category is also a good example of this.

3. Link List - Any page that has more than 3 links has problems on listing the items consecutively.

To a seasoned CSS expert, I can't think this would take a great deal of time.

1. Please only CSS/xhtml experts. I will have to integrate any stylesheet/template changes into my dynamic site, so clean code only!

2. If you wish to bid, please just comment on the problem at hand. No stock responses about your generic skillset.

3. All code changes must be x-browser (IE, Firefox, Opera, etc).

Thanks for viewing my auction.

Færdigheder: Web Design

Se mere: top sort, top problem, template design help page, problem categories, list community problems, link template website, inline design, dynamic problems, dynamic problem, design and drill, c template example, community dynamic, c code template, bit problems, bit problem, at&t community, stock categories, design a cat, responses, more css changes for, hyperlink, design cat, css, cat, css sub page

Om arbejdsgiveren:
( 1 bedømmelse ) London, United Kingdom

Projekt-ID: #53218

Tildelt til:

Please check PM!

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Why You Need to Know Fehmi Karahan

The president and CEO of the Karahan Cos. is a driving force behind Legacy West

Why You Need to Know Fehmi Karahan

Because he’s playing a critical role in developing Legacy West, one of the largest and most expensive commercial developments in Texas. The $2 billion+ project on 240 acres in Plano is anchored by both the corporate headquarters for Toyota North America and FedEx Office, and a large operations center for Liberty Mutual. It is an extension of the hugely successful Legacy mixed-use development that sits just to the east.

The personable, Turkish-born developer is known in the industry for his vision, his ability to assemble talented teams, and for creating destinations with heart and soul. “Growing up in Istanbul, a city that is some 3,000 years old, and being able to travel around Europe and seeing outdoor environments and gathering places gives you intuition on how these things work and what people like,” Karahan says. “I’m fortunate to have been given the tools to create these places.”

He came to America in 1978, on a scholarship from a Turkish company to pursue a master’s degree in New  York. The cosmopolitan city was similar to Istanbul and Paris, but Karahan craved a different experience. He found it in Texas, during a holiday trip. “Texas was real America to me; the people were so friendly,” he says.

He decided to stay and get his MBA from the University of North Texas. Not long after, he was playing soccer with an international group of players when one of the guys asked if he would like to join his real estate company. Karahan went on to launch another firm with a co-worker. In 1992 he ventured out on his own with The Karahan Cos., focusing on neighborhood and grocery-anchored retail projects.

The developer’s big break came in 1998, when EDS chose him to oversee The Shops at Legacy in Legacy Town Center off the Dallas North Tollway. Not everyone initially agreed with his vision to create an open-air, pedestrian-friendly project, but the critics have long since been silenced. The urban lifestyle center is arguably one of the most successful mixed-use developments in the country. About 60,000 people now work and live in the Legacy area, where office development stands at about 17 million square feet.

“We have been able to change the North Texas map overall with The Shops at Legacy,” Karahan says. “It has become such a regional place. Today, all big companies want to be near amenities to attract the talent and retain them.”

Karahan’s big break came in 1998, when EDS chose him to oversee the Shops at Legacy.

Even back in the early days of Legacy Town Center, Karahan had his eye on the 240 acres surrounding J.C. Penney’s corporate campus on the west side of the tollway. The retailer had acquired 360 acres when it moved from New York to Plano in 1987, but only used about a third of it for its headquarters campus. Karahan approached the company, but it wasn’t interested in selling.

J.C. Penney changed course in 2014, and decided to leverage the value of its prime property. It invited five companies to vie for the right to develop the land. When Karahan learned he would be competing against big boys like Trammell Crow Co., he called for reinforcements, ultimately forming “Team Legacy” with  office developer KDC and multifamily developer Columbus Realty Partners. Combined, the three companies had done more than $1 billion in projects at the original Legacy.

“When you look at those partners, Columbus Realty’s Robert Shaw is the best residential developer anywhere,” Karahan says. “The same with KDC. When you look at their corporate campuses, they are builders and developers and no one is better. It really is the dream team.”

Team Legacy quickly secured a headquarters for FedEx Office, and followed it up with a whopper: a 2.1 million-square-foot North American headquarters for Toyota North America. Things escalated from there, with a big campus for Liberty Mutual and a multitenant office tower from Gaedeke Group.

The magnitude and velocity of office development has helped jump-start the other components of Legacy West. They include 320,000 square feet of retail space (including a market hall with several new restaurant concepts), more than 600 luxury apartments, 100 single-family homes, and a 30-story, 152-unit luxury condo tower.

“It is very exciting to see in such a short period of time so much success achieved,” Karahan says.

Legacy West also is getting an $82 million Renaissance hotel. The 300-room property will include 26,000 square feet of conference space. Funded by the Sam Moon family, it will be adjacent to retail and residential buildings and sit along the Dallas North Tollway. Karahan is working with the city of Plano and the North Texas Tollway Authority to connect the east and west sides of Legacy by making the bridge over the tollway more pedestrian-friendly. An estimated 13,000 to 15,000 people will work at Legacy West, with annual payrolls reaching $1.8 billion. “The economic impact—not only for Plano, but North Texas and the state of Texas—is pretty mind boggling,” Karahan says. “As a development, Legacy West is like winning The Masters. These are fortunate times for Texas.”


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abandoned building

Recent Headlines
Tompkinsville »

A home at 11 Nixon Ave. has been left in disarray for nearly 19 years, said people who live nearby.

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The unidentified man was discovered in a vacant building at South Fourth Street and Bedford Avenue.


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Wet Hop American Summer After Dark

Brewpub Exclusives

Original Release Date:

Wet Hop American Summer is our annual Fresh Hop beer, with the recipe changing each harvest season.  This year we decided to go with a dark American wheat beer for the base recipe with 40 pounds of fresh Citra hops, which were harvested at ripeness and then immediately shipped to our brew pub over night.  2-Row, wheat, and cara malts were mixed with a smidgen of Briess Midnight Wheat, a debittered black wheat malt, which lends this ale it’s blackish hue with mahogany highlights.  95% percent of the hops were added in the last 15 minutes of the boil and post-boil combined, for maximum flavor and aroma effect.  The result is a dark but extremely smooth and drinkable ale with a huge nose of juicy fruit and grassy mango, with pungent hops, bready malt, and coffee notes coming through in the flavor.  The finish is clean and silky without the lingering bitterness that one might expect from the aroma of this beer.  One can easily envision themselves strolling amongst the hop fields after the sun has gone down while enjoying this special brew.

Wet Hop American Summer After Dark goes on tap Friday, September 28, 2012 and will be available until it is gone.

Due to limited availability, our Brewpub Exclusive beers are not available in growlers.

Looking to find Dogfish brews in your neck of the woods? We currently sell in 36 U.S. states plus Washington D.C., although we hope to add more someday! Select your brew of choice, enter your zip code and we will tell you where it has been delivered in the past 60 days. But wait! Before you hop in your ride and drive to pick up that elusive Dogfish you see on the screen, please, please call ahead to confirm availability. Just because a beer has been delivered doesn’t mean it is still on the shelves or that the keg has been tapped.

Here is the list of where we currently have wholesalers.

Find This Beer Near You


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drive alive holidays
Driving holidays in Europe - Plan your self-drive motoring holiday

Hotel search

Tick as many as you like then click 'Find Hotels', but remember that the more you tick the less your choice of accommodation

 Results: 1 to 3 of 3
Videbæk (1.0km from town centre)
Hotel Falken
Hotel Falken is in Videbæk, 30 minutes’ drive from the sandy North Sea beaches. It provides modern en-suite rooms and traditional Danish cuisine. Guests can enjoy free Wi-Fi, pool and sauna access. All of Falken’s rooms feature a work desk and cable TV access. After a filling meal in the restaurant, guests can relax with a game of pool in the bar. Other facilities include garden with playground. Jyllands Park Zoo is 18 km from Falken Hotel. He[More...]
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drive alive holidays
Driving holidays in Europe - Plan your self-drive motoring holiday

Hotel search

Tick as many as you like then click 'Find Hotels', but remember that the more you tick the less your choice of accommodation

 Results: 1 to 11 of 11
Novalaise (5.6km from town centre)
Novalaise Plage
Novalaise Plage is located on Lake Aiguebelette near Chambéry. It has a private beach and offers free WiFi and free parking. Rooms are bright and spacious with simple and delicate decoration. They have en suite facilities, TV, balcony and a view over the lake. The restaurant offers sophisticated cuisine using local products. Guests can enjoy a continental breakfast served in the restaurant or on their private balcony. The staff at Novalaise P[More...]
Novalaise Plage Close [x]
Champagneux (5.9km from town centre)
Hôtel les Bergeronnettes
Offering a heated indoor pool, this chalet-style hotel is set on the heights of the Rhone-Alps region. Savoyard dishes are served in the restaurant and Walibi Theme Park is 10 km away. A balcony with a view of the mountains is offered in the modern guest rooms. Each soundproofed room has an LCD TV and the en suite bathrooms include a hairdryer and free toiletries. You can sample traditional dishes, including the hotel’s speciality of frog’s leg[More...]
Hôtel les Bergeronnettes Close [x]
Novalaise (6.1km from town centre)
Fleurs du Lac
Offering free bikes, Fleurs du Lac is a B&B located in Novalaise. Free WiFi access is available. The property is 300 metres from Aiguebelette Lake. The double room features a private balcony with lake views, satellite TV and a wardrobe. There is also an electric kettle. Featuring a bath, the private bathroom also comes with a hairdryer and bathrobes. A continental breakfast is served every morning at the property. Lyon - Saint Exupery Airport [More...]
Fleurs du Lac Close [x]
Dullin (6.3km from town centre)
Auberge de Mandrin
This hotel is just an 8-minute drive from the Mandrin Caves and Montfleury Castle. It offers free mountain bike hire, free mini golf and a tennis court, just 25 km from Chambéry and 2.5 km from Aiguebelette Lake. Decorated in a simple style, the rooms at Auberge de Mandrin offer an LCD TV and views of the countryside or mountains. Each one is also equipped with ironing facilities and an en suite bathroom. A continental breakfast is served every[More...]
Auberge de Mandrin Close [x]
Saint-Alban-de-Montbel (7.4km from town centre)
Les Lodges du Lac
Offering a seasonal outdoor pool, a garden and a terrace, Les Lodges du Lac is set in a 2-hectare park and is located in Saint-Alban-de-Montbel. Free WiFi access is available in this hotel. The soundproofed rooms have a flat-screen TV and a balcony or terrace. Featuring a bath or shower, the private bathroom also comes with a hairdryer. The on site restaurant offers fresh and seasonal food. A bar is also available. Guests can also enjoy evenin[More...]
Les Lodges du Lac Close [x]
Lepin-le-Lac (8.9km from town centre)
Les Sirenes
With direct access to the Aiguebelette Lake, Les Sirenes features a private beach, rooms with an LCD TV and a gourmet restaurant. With free Wi-Fi throughout, the property is 22 km from Chambéry. Each room is provided with a private bathroom, a desk and a wardrobe. Some of the rooms have a balcony and family rooms are also available. The breakfast is served daily in the hotel’s dining room. Traditional specialties are proposed at the restaurant,[More...]
Les Sirenes Close [x]
Lepin-le-Lac (9.5km from town centre)
La Clairière du Moulin
Located between Lepin-le-Lac and Aiguebelette-le-Lac, 2 km from Aiguebelette Lake, La Clairière du Moulin is set in an 18th-century farm house with 4.7 hectares of land, with a garden and terrace. It offers free Wi-Fi access, BBQ facilities, tennis table and an outdoor dining area. All rooms offer a view, tea and coffee making facilities, as well as an en-suite bathroom with a hairdryer and free toiletries. Breakfast including hot drinks, fruit[More...]
La Clairière du Moulin Close [x]
Attignat-Oncin (11.1km from town centre)
Les Grands Champs
Set in a renovated farmhouse, Les Grands Champs B&B is located in the Regional Park of Chartreuse, 6 km from Lake Aiguebelette. The property includes a sun terrace and boules pitch. Guests can borrow boules balls and snow shoes free of charge. Decorated in a traditional Savoyard style or in an African design, the rooms are located on the ground floor. A TV is available for free upon request, and some rooms include free Wi-Fi. A hairdryer is supp[More...]
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drive alive holidays
Driving holidays in Europe - Plan your self-drive motoring holiday

Hotel search

Tick as many as you like then click 'Find Hotels', but remember that the more you tick the less your choice of accommodation

 Results: 1 to 10 of 10
Gamberale (4.0km from town centre)
Hotel Villa Danilo
Set in the heart of the National Park of Maiella, Hotel Villa Danilo is an ideal place to relax, featuring a large outdoor pool and a luxury wellness centre. This charming hotel is surrounded by unspoilt nature, 10 minutes' drive from the medieval town of Gamberale. During winter, the area becomes popular with ski lovers and you can find a number of ski slopes suitable for all levels. The Villa Danilo Hotel opened a modern wellness centre in 20[More...]
Hotel Villa Danilo Close [x]
Ateleta (5.7km from town centre)
Rifugio del Cavaliere
Offering barbecue facilities, Rifugio del Cavaliere provides accommodation in Ateleta. The aparthotel provides guests with a terrace, mountain views, a seating area, a flat-screen TV, a fully equipped kitchen with a microwave, and a private bathroom with bath or shower and a hair dryer. A balcony with pool views is offered in all units. Guests at Rifugio del Cavaliere can enjoy an Italian breakfast. At the accommodation you will find a restaura[More...]
Rifugio del Cavaliere Close [x]
Ateleta (5.9km from town centre)
Albergo Due Monti
Offering a traditional Abruzzo restaurant, a bar and garden, the Due Monti is 740 metres above sea level in Ateleta. Roccaraso ski slopes are 15 km away and the area is ideal for hiking, horse riding and biking. With free WiFi, rooms at Albergo Due Monti hotel are soundproofed and en suite. Each includes a computer, individually controlled heating and parquet floors. Guests enjoy an Italian-style breakfast daily. The hotel is about 30 minutes' [More...]
Albergo Due Monti Close [x]
Castel del Giudice (5.9km from town centre)
Borgotufi Albergo Diffuso
Borgotufi Albergo Diffuso in Castel del Giudice provides accommodation with a shared lounge and a bar. Both free WiFi and private parking are available on site. All units in the hotel are equipped with a TV. Each room is fitted with a private bathroom, while some rooms come with a mountain view. The rooms have a safety deposit box. An Italian breakfast is available every morning at the property. Guests can enjoy a meal at the on-site restaurant[More...]
Borgotufi Albergo Diffuso Close [x]
Quadri (7.0km from town centre)
Da Filandro
Situated in Quadri, Da Filandro provides free WiFi throughout the property. There is a restaurant. At the hotel, every room is equipped with a desk and a flat-screen TV. Rooms are complete with a private bathroom fitted with a bath or shower, while selected rooms also boast a balcony. All guest rooms at Da Filandro have air conditioning and a wardrobe. Breakfast is available every morning, and includes à la carte and Italian options. Roccaraso[More...]
Da Filandro Close [x]
Capracotta (9.6km from town centre)
Hotel Capracotta
Hotel Capracotta is located 5 minutes' walk from Capracotta's main square and a one-hour drive from Roccaraso. It offers bright and spacious rooms with mountain views. Hotel Capracotta has its own ski deposit and runs an affordable shuttle service to the ski slopes on request. There is a ski school close by as well as tennis courts and football fields. There is a TV lounge with an open fire and the hotel has a bar, a games room and a playroom. [More...]
Hotel Capracotta Close [x]
Roccaraso (9.7km from town centre)
Hotel Ansharius
Set 4 km from the centre of Roccaraso, Hotel Ansharius offers modern, elegant rooms with a balcony. The spa features a Turkish bath, sensory showers, and a hydromassage pool. The rooms and suites of Ansharius Hotel come with a flat-screen TV with Sky channels, a minibar, and a tea/coffee maker. Some rooms include free access to the spa. Breakfast is an extensive buffet of sweet and savoury food, including homemade cakes and croissants. The bar [More...]
Hotel Ansharius Close [x]
Capracotta (9.8km from town centre)
BiancaNeve B&B
Located in Capracotta, BiancaNeve B&B offers a garden. Among the facilities at this property are a shared lounge and luggage storage space, along with free WiFi throughout the property. Guests can enjoy mountain views. At the bed and breakfast, each room has a desk, a flat-screen TV and a private bathroom. All units feature a wardrobe. Guests at BiancaNeve B&B can enjoy a continental breakfast. The accommodation offers a sun terrace. Skiing is[More...]
BiancaNeve B&B Close [x]
Roccaraso (9.8km from town centre)
The Stone House
Set 8 km from Pallottieri and 8 km Pino Solitario, The Stone House offers accommodation with a kitchen in Roccaraso. The property is 8 km from Monte Pratello and 8 km from Crete Rosse. This holiday home comes with a bathroom with a bath, a bidet and free toiletries. Skiing can be enjoyed nearby. The nearest airport is Abruzzo Airport, 65 km from the holiday home.[More...]
The Stone House Close [x]
Castel di Sangro (12.7km from town centre)
Residence Les Amis
Residence Les Amis offers self-catering apartments set in luxurious chalets on the Apennine Mountains. Parking is free and the ski slopes in Roccaraso are 15 km away. Each apartment at the Residence offers panoramic views of the quiet surroundings. Apartments feature a fully equipped kitchen, and a living room with flat-screen TV. Les Amis Residence is in Roccacinquemiglia, a short drive from Casteldisangro.[More...]
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About our Orthodontic Office

696C0055 (1)

We are very proud of our treatment facility. It stands as the first limestone office building in Katy/West Houston, Texas and set a trend for many more “Hill Country” inspired structures in this area. The stone was transported from a quarry in central Texas. It is accented with brick-bordered arches, sections of tin roof and topped off with a picturesque cupola. The design came about as an amalgamation of the thoughts and visions of architect Don Leighton-Burwell and Dr. Anderson.

The interior was designed to offer a relaxing, casually elegant environment that puts visitors at ease, while at the same time functions as an efficient layout for the delivery of orthodontic patient care. Most of the art displayed consists of photographs of our treated patients. Their faces and smiles are the “art forms” we work with them to create. We want them to be “showcased”.

We look forward to your many visits to our Katy, TX orthodontics office. Our hope is that you enjoy each and every one of them. Drop by and say hello soon!


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Skip to Content

deleted in colorectal carcinoma

Definition: A transmembrane receptor important in axonal development. Despite its name, its function and importance in cancer development remain unclear.

Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.


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Pronunciation: in'kwi-lin, -lin

Definition: An animal that lives habitually in the abode of some other species (an oyster crab within the shell of an oyster) causing little or no inconvenience to the host.

[L. inquilinus, an inhabitant of a place that is not his own, fr. in, in, + colo, to inhabit]

See Also: commensal

Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.


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Pronunciation: in'tron

Definition: A portion of DNA that lies between two exons, is transcribed into RNA, but does not appear in that mRNA after maturation because the intron is removed and the exons spliced together, and so is not expressed (as protein) in protein synthesis. By customary usage, the term is extended to the corresponding regions in the primary transcript of mRNA before maturation.

Synonym(s): intervening sequence

[inter- + -on]

Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.


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About your stayStep 1 of 3

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2265 East Sharon Road
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Late summer? Bedfordshire set for sunny spell

Late summer for the UK?
Late summer for the UK?

Temperatures are set to soar above average across the UK after a dismal August saw Britain experience its coldest summer in three years.

By Thursday parts of the south east of England and East Anglia will see a top temperature of 23C, well above the 19C average for this time of year.

Much of the rest of England and Wales could hit a high of 22C, with Scotland enjoying a balmy high of 20C - four degrees above its September average.

Although temperatures over the next ten days are unlikely to rise to the high of 27C experienced last year, it will still be warmer than much of the past summer when temperatures sat at an average of just 13.9C.

Gemma Plumb, a meteorologist at MeteoGroup, said: “There is currently an area of high pressure sat over the UK which is bringing a lot of dry and fine weather across the country.

“This high is expected to drift away to the east towards Scandinavia on Wednesday, bringing up some warmer air from the continent.

“Most of this week will be dry and fine across the UK with spells of sunshine during the days and clear spells overnight.”

However those hoping for an Indian Summer may be disappointed as a low pressure system is expected to start to move in from the west over the weekend, bringing the risk of some rain and a settling of temperatures back down to the September average.


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Salon d’Eau in Paris

Between the historic Bastille and the famous Père Lachaise cemetery, the Salon d’Eau in Paris has for many years welcomed visitors from all over the world. Here, Duravit presents the latest bathroom trends and makes them come alive for visitors.

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Infographic Template Galleries

Created with Fabric.js 1.4.5 Allow you to assess yourself and others on our Values and our Mission as 6 individual categories instead of 2. Provide more notice to you and your manager to allow plenty time to prepare and carry out your meetings. thought it waseffective Others thought we should work on the technical operations Personal Best 93.6% 42.6% 48.9% What did you think of the guide & communication? What were your overall impressions? Are you confident about achieving your goals? 40.4% 12.8% 46.8% Heres what some of you had to say "Really simple to complete. Enjoyed the process and how easy it was to use. Also helped me create very clear objectives & goals of which some are already completed." "It was great to focus on my goals and talk them through with my Manager. I found the process to be positive and energising." "I liked the direct, down to earth approach to the process." "I have a great relationship with my manager and the discussion was incredibly upbeat and I came out feeling very inspired." "I felt the scoring was too rigid - we should have been scored on six individual categories." Describe your Personal Best experience Some things we've learned and will work on for next time Improve the technical process within the HR Hub. Ensure that goals and development objectives are tracked and followed up on regularly by managers and individuals themselves. you have to Go for it! Weve already met with the people at Cascade to tell them all the things we would like to be better within the Personal Best process and they are working on these now. Most people like the question on the Personal Best Life Goal. Weve made this change already and are testing it now. Consider it done! Great; we will keep this in and keep it to just the one question. earn it by delivering your Personal Best! 8.5% Thank you for taking part in our survey. Your feedback is always important to us to help us develop our people processes so we are the best we can be. Survey results Much better than I expected Disappointing I have absolute faith I'm confident Not so sure Did exactly what it said on the tin Remember, no one will serve up success and reward to you on a plate
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Are you ordering for a group?

We've discontinued Premium Catering, but you can still place a group order with EAT Club!

Get a taste of EAT Club

Enter your delivery address to see the menu for your area and place an order. Note: minimum of 5 meals required.

See Menu


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Happy Easter!

On Thursday 28 March, EC Cape Town DOS, Nicoletta Di Gia, went to every classroom handing out delicious Easter eggs to all students!

*A reminder to all our students that Friday 29 March and Monday 1 April are public holidays and EC Cape Town will be closed.  Classes will resume on Tuesday 2 April.

Happy Easter!!

20130328_095456 20130328_100220 20130328_101914


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Get Crucial Ballistix Elite 16GB (2x 8GB) Desktop Memory Kit from
Price:   $59.99
Discount:   Reflected in sale price
Shipping:   Free on $49.00 or more
Final Price:   $59.99 + Free Shipping
Checkout discounted gift cards for additional savings.

Price Comparison

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Price Comparison provided above is as on 04-11-2016. Shipping cost (if any) is based on shipment to our office location. Please double check the shipping & final price on the merchant website before placing any orders.

Other Information

  • UPC: 649528757838
  • UPC 14: 00649528757838
  • Model/MFR/MPN: BLE2KIT8G3D1869DE1TX | BLE2KIT8G3D1869DE1TX0

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text:
East Lothian take charge at top of Premier Division B

Graham Robertson was in fine form for East Lothian
Graham Robertson was in fine form for East Lothian
Have your say

East Lothian gents gave their prospects of clinching top spot in the indoor bowls Premier League Division B a tremendous boost with a brilliant 78-59 away victory over Aberdeen.

The outcome – made even more vaulable as fellow joint-leaders Ardrossan suffered a shock 74-68 defeat at home to bottom side Balbardie – reflects a strong team performance with wins chalked up by the rinks skipped by Graham Robertson, Scott Kennedy and Billy Mellors while the defeat of Derek Oliver was just by a single shot. Robertson inspired the EL effort with the team captain skipping Mark Johnston, Willie Wood MBE and Joe Mower to a 21-10 win over Gary Forbes while Andrew Jeffrey, Dean Riva, Dougie Berwick and Scott Kennedy added a 20-15 success over Eric Gallen.

Mellors skipped Calum Darling, Lewis Betts and Glenn Blair to a battling 19-15 win over Mike Stephen while Ross Thomson, Stewart Thomson, Jamie Higgins and Oliver were pipped 19-18 by Kevin Currie.

The league table with seven of the ten fixtures completed reads: East Lothian 10, Ardrossan 8, Lanarkshire 8, Aberdeen 6, Paisley 6, Balbardie 4.

Elsewhere, Bainfield edged an 81-80 thriller at home to Blantyre in Division A while high-flying West Lothian made it seven wins out of seven in Division 1 North with their 90-76 win away at Abbeyview.


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Private Debt Investment Professional

  • Competitive
  • Zug, Switzerland
  • Permanent, Full time
  • Partners Group AG
  • 13 Feb 18 2018-02-13

We are one of the largest global private markets investment managers, serving over 900 institutional investors worldwide. We have USD 66 billion in assets under management and more than 1000 professionals across 19 offices worldwide. Partners Group is an equal opportunity employer committed to cultural diversity.

What it's about

Partners Group is one of the leading players in the private debt market, investing across the capital structure including senior, unitranche, second lien and mezzanine financings. We now look to add an exceptional Associate to the growing debt team, based in Zug, Switzerland. What it's about:
•Prepare detailed qualitative and quantitative analysis for the assessment of prospective private debt investments. Key responsibilities will include LBO modelling, analysis of due diligence materials, writing internal investment committee memorandums and contributing to investment committee discussions.
•Assist with the ongoing management of private debt investments including monitoring of investee company performance, assessing waiver and amendment requests and attending management meetings.
•Various other tasks such as valuation assessments, product reporting, market research and supporting Partners Group fundraising efforts.

What we expect
•Bachelor’s degree from a top university with a focus on Finance, Economics or Business Administration.
•2-4 years of relevant work experience in private equity, investment banking, investment management or accountancy within a top-tier institution.
•Excellent analytical skills and attention to detail.
•Team player with strong interpersonal and communication abilities.
•Fluent German and English language skills. Other European languages desirable but not essential.
•Some European travel will be required.


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Ford Explorer Fleet SUV Sales

Ford Fleet Explorer SUV Sales

By developing a proactive fleet acquisition strategy, our services help you buy fleet vehicles including Ford Explorer SUVs at the right price by only paying for the equipment you need, and locking in at the lowest invoice cost.

With our manufacturer relationships, we help you to negotiate the best possible incentives for buying Ford Explorer SUVs. When ready, we can deliver your Ford vehicles ready to go, complete with your aftermarket additions and customizations, even down to brand and image-supporting decals for your Ford commercial vehicles.


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UK Wordcamps & WordPress meetups

UK Wordcamps & WordPress meetups

Andy Holland

It’s safe to say that WordPress is an institution. Used by over 60 million websites and powering a total of 23% of the web, you’ll be hard pushed to find a more popular—and more effective—open-source CMS (WP is #1!).

At any given time you won’t be too far away from the church of WordPress. You’ll find their meet-ups all over the world; from Brisbane to Birmingham, and everywhere in-between, there are WordPress fanatics getting together and discussing things like operation, development, updates, and scaling.

Looking closer to home, WordPress UK groups generally meet during the evening and convene on a monthly basis. Leeds and London are two places which have their own meet-ups—London with several different groups—and it’s these meet-ups which we are going to look at in more detail.

Leeds WordPress Meet-up

WordPress Leeds is, in their own words “an informal organisation to help promote WordPress and Blogging events in Leeds and West Yorkshire”. They host a main event, held monthly, where Bloggers, Journalists, Designers, Developers and anyone interested in the blogosphere and Digital Publishing get together and talk WordPress. Talks can get quite technical, and entry is free but ticketed due to capacity restrictions.

Organisers: Matthew Haines-Young, Samantha Miller, Tim Nash, Dave Pullig, Steph Walker

Group Twitter: @wpleeds

Details: Their main get together is held 6:00pm on the 4th Tuesday of the month at DLA Piper.

London WordPress User Group Meet-up

London WordPress User Group (WPUGL) is a free, informal meet-up based in central London, which places an emphasis on encouraging everyone to share what they know—not just developers—and learn from each other.

Each of their events is focused on one specific aspect of WordPress, chosen by its attendees, and often includes hands on ‘peer to peer’ workshops, advice from WordPress professionals, and of course the chance to network with fellow WordPress users.

Organisers: Eugene and Peter J.

Group Twitter: @wpugl

WordPress London

WordPress London, held the last Thursday of every month, is a development focused meet-up for both developers and users of WordPress. Here the meet-ups usually take the form of 2-3 talks, an open Q&A session, and the occasional trip to the pub.

Organiser: Dan Maby

Group Twitter: @wpldn

Details: Meetings normally every third Thursday of the month.

London Greenwich WordPress Meet-up

WordPress User Group Greenwich, or ‘WUGG’ is “A local group where WordPress users commune and share knowledge about WordPress and related activities such as blogging, social media, image editing, and general web skills.”

Entry here is restricted too, but for different reasons. WUGG want to keep the conversation focused around running high-traffic, high-volume enterprise WordPress websites, so they have a policy in place to evaluate member requests on a case-by-case basis.

Organiser: Gareth

WordPress Weekend Conferences

If you want to immerse yourself in WordPress for more than just one night, get yourself to a WordPress conference. WordPress UK conferences last one or two days and usually take place over the weekend. Or for the more adventurous, you can take a trip to Vienna for WordCamp Europe. Here’s the details of the next UK conference coming up early next year, along with WordCamp Europe:

A Day of REST 2016 takes place on Thursday 28 January 2016 in London.

WordCamp Europe 2016 takes place on 24-25 June 2016 in Vienna, Austria.

Let us know which meetups and WordCamps you like to go to – maybe we’ll see you there!

Andy Holland

Author Andy Holland

More posts by Andy Holland


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Reference address : https://www.ellopos.net/elpenor/greek-texts/fathers/origen/contra-celsum-2.asp?pg=16

ELPENOR - Home of the Greek Word

Three Millennia of Greek Literature

Origen, AGAINST CELSUS, Part III, Complete

Translated from the Greek original by Frederick Crombie.

Origen Resources OnLine & in Print

Icon of the Christ and New Testament Reader

This Part: 128 Pages

Page 16

Chapter II.

"But that certain Christians and (all) Jews should maintain, the former that there has already descended, the latter that there will descend, upon the earth a certain God, or Son of a God, who will make the inhabitants of the earth righteous, [3687] is a most shameless assertion, and one the refutation of which does not need many words." Now here he appears to pronounce correctly regarding not "certain" of the Jews, but all of them, that they imagine that there is a certain (God) who will descend upon the earth; and with regard to Christians, that certain of them say that He has already come down. For he means those who prove from the Jewish Scriptures that the advent of Christ has already taken place, and he seems to know that there are certain heretical sects which deny that Christ Jesus was predicted by the prophets. In the preceding pages, however, we have already discussed, to the best of our ability, the question of Christ having been the subject of prophecy, and therefore, to avoid tautology, we do not repeat much that might be advanced upon this head. Observe, now, that if he had wished with a kind of apparent force [3688] to subvert faith in the prophetic writings, either with regard to the future or past advent of Christ, he ought to have set forth the prophecies themselves which we Christians and Jews quote in our discussions with each other. For in this way he would have appeared to turn aside those who are carried away by the plausible character [3689] of the prophetic statements, as he regards it, from assenting to their truth, and from believing, on account of these prophecies, that Jesus is the Christ; whereas now, being unable to answer the prophecies relating to Christ, or else not knowing at all what are the prophecies relating to Him, he brings forward no prophetic declaration, although there are countless numbers which refer to Christ; but he thinks that he prefers an accusation against the prophetic Scriptures, while he does not even state what he himself would call their "plausible character!" He is not, however, aware that it is not at all the Jews who say that Christ will descend as a God, or the Son of a God, as we have shown in the foregoing pages. And when he asserts that "he is said by us to have already come, but by the Jews that his advent as Messiah [3690] is still future," he appears by the very charge to censure our statement as one that is most shameless, and which needs no lengthened refutation.

[3687] dikaiotes.

[3688] akolouthias.

[3689] pithanotetos.

[3690] Dikaiotes not Dikastes.

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Reference address : https://www.ellopos.net/elpenor/greek-texts/fathers/origen/contra-celsum-2.asp?pg=16


text: Related Information for 1080 In 1995 the 1st incarnation of 1080 began in New Plymouth. Bringing together Punk with pop sensibilities. After recording a demo late that year both guitarists left with bassist Biggy (R.I.P) leaving to do vocals for Inebriation.The remaining members Emily and Craig H soon recruited ex Nefarious bassist Craig Toxic and guitarist Lyn M. They released their 1st EP 'Thrills, Chills and Chemical Spills' before disbanding in ’97.Undeterred drummer Craig produced a new.. read more


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Fibromyalgia linked to hepatitis B vaccine

Lana Bandoim's picture

A recent study focused on the connection between fibromyalgia and the hepatitis B vaccine. Researchers found that some patients who received the vaccine later showed ASIA syndrome symptoms and suffered from fibromyalgia and chronic fatigue syndrome. There is a link that needs to be studied with a larger group of patients.

The ASIA syndrome is defined as autoimmune/autoinflammatory syndrome induced by adjuvants. Adjuvants are substances that are commonly found in vaccines to enhance them by affecting antigens. Essentially, adjuvants can motivate the immune system to kick into high gear after a vaccine. They can vary greatly from inorganic substances to combination products. In the study from Israel, researchers found that some patients had adverse reactions to the hepatitis B vaccine that may have been related to the adjuvants.

Both fibromyalgia and chronic fatigue syndrome were reported by some patients after receiving the hepatitis B vaccine. Researchers felt the adverse reactions may have been temporary, but more studies are needed in this area to determine the long-term impact. Although other vaccines have been linked to these autoimmune disorders, hepatitis B seems to be the more prominent focus in medical research.

The hepatitis B vaccine is designed to protect people from HBV (hepatitis B virus) which can cause severe liver damage, cancer and death. It is spread by bodily fluids and other means that can result in either an acute or chronic infection. The CDC estimates 43,000 new cases appear in the United States every year with another 800,000 to 1.4 million chronic cases in the United States. An estimated 350 million people are infected with hepatitis B around the world. The researchers who conducted the fibromyalgia and chronic fatigue syndrome study do not recommend that people avoid vaccines as a precaution. They carefully worded their study to let patients and medical staff reach their own conclusions.

Read more about fibromyalgia:
Memantine drug shows promise for fibromyalgia
Fibromyalgia study focuses on brain stimulation to fight pain

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I had the vaccine in the 1990's and I have Fibro. I would love to know more about this study.
I had 2 series of HBV because as an RN, I was forced for the first series..a year later I sustained a needle stick and tested no titer to this and the hospital made me get another series..the medical director found out and had a fit and said absolutely no more vaccines of this.It wasn't 2 or 3 months later I got ill and was diagnosed with CFS and Fibromylagia.I'm now on disability after suffering with this for over 20 years. I definitely would like to learn more about this study.
I too was given a series and didn't test for the titre so got another series during nursing school. After each injection I got sicker. Mine started with horrible digestive symptoms that lead to (at this point) over 4 years of uncontrolled diarrhea, exhaustion, pancreatic issues, blood sugar issues, lost function of my left arm, later developed what feels like seizures, I have all sorts of inflammatory issues and have been unable to work for over 4 years. I am just now piecing together the possibility that it's related to my vaccines. I have lost everything including friends and family who think I'm just lazy. I am so angry at the fact that I gave everything to put myself through nursing school as a single mother to make a better life for my son. I worked hard and graduated absolute top of my class... now I'm drowning in student debt and am in deeper poverty than before I started... I've provided a worse life for my son and the thought it may be due to forced vaccines has me pretty angry.
Hi, I would love to talk to you. We have similar stories. I just read about this for the first time last night. It was actually an informational ad on Facebook. I've been reading a lot since then and want to find out more and what this may do to help my case. I was a Registered Dental Assistant for 24 years. My first Hep B series was in 1992. In 2002, i had a Titer test done, it came back that I wasn't protected. So I had to repeat the series (I believe it was negative even after that). I did experience some health issues, but nothing diagnosed then. In 2011, i started not feeling well and by spring of 2012, I was really sick, had to quit working 7/2012. I didn't get a Fibromyalgia diagnosis until April, 2, 2015, I filed right away, but to date, I have no income and I'm separating from my husband, we married 11/11/11, but I went down hill not long after and he isn't supportive at all. So this illness has taken my career, my health and now my husband from me and I have no income. If this indeed is from this immunization that I had to have due to my profession, I am very interested in knowing what my recourse is. Any suggestions? This has ruined my life. I hope to hear from you. I'd be happy to give you my # if that is easier. Thank you, Susan
I had the first 2 of the HBV series while working in a direct patient care role in early 2001. Years later when doing an internship at a hospital for a career field change they insisted I receive a third dose. I'd always associated the start of my Fibro symptoms with my second shoulder surgery in Sept of '04, but in looking at my shot record that 3rd HBV does was in Feb of '05. It would be interesting to see a study like this done in the US.
I had hep b vaccine in the late 90s and again in 2003 . I have suffered with chronic pain since the first jab and got diagnosed with fibromyalgia finally 4 yrs ago after undergoing different investigations for seven years prior to my diagnosis. I would be very interested in learning more. Thanks.
I am a direct patient care worker, and had 3 HBV shots in 2000, in 2004 I was diagnosed with Fibromyalgia. I would like to see more studies like this done. I live in Canada. I attributed my pain to a number of back injuries from work, but seeing this study, it makes more sense. Please bring the study to Canada and the US. I would volunteer to be in the study.
I worked as a Medical Secretary but because I did cover reception and assisted the Nurses and was a First Aider I was given Hep B vaccinations for work. The first lot didn't really take and my bt result was only 10, so I had a second lot all so I could work. They then bullied me out of work when I became ill! I'm now nearly divorced and can't work and my husband told me that my illnesses of Fibro and CFS and how I wasn't dealing with them was the final straw hence the divorce. I'm now living alone, on benefits and still struggling with these awful conditions and others and think it is not fair that I have lost everything, family, work, self esteem, strength etc possibly all because of a vaccine! I would be very interested if they could prove this, then many of us who have worked caring for people in our work can claim compensation from the employers to forced this upon us. I definitely want to know more. I would also like to wish all those suffering with Fibro or CFS/ME or similar conditions all the best and let you know that you are not alone as there are plenty of us out here around the world suffering just like you. Lots of Love Chris xoxo
I was diagnosed with fibro about 4 years ago and like so many people struggled with the every day chores. I have just had my Hep B vaccine and after reading the article about how Hep B my be the cause of fibro wondered if I should expect any ill effects on my condition ?
I was totally fine fit as a fiddle until I had the hep b injections them all my fibro symptoms happened after I had hep b course 10 years ago just been diagnosed with fibro took a long time for my diagnoses
I live in uk I had hep b vaccine course 10 years ago working in health care profession I have been poorly ever since and just diagnosed with fibro I am very interested to see the research to this link of fibro and hep b, fibro is a very horrible condition that effects your whole life tremendously I have not worked for 4 years now due to this illness.seen numerous consultants tried all kinds of pain relief physio hydrotherapy traction tens machine I am on currently on a list to see accunpuncture nurse see if that works did it work for anyone ?
I was a very healthy 63 year old who hiked 40 to 50 miles / week. I had two of the Hep B shots and my life changed in an instant. Unable to walk more than 5 minutes now and it has been almost 4 years. I will say last year, for some reason, I did better and was walking about 2 miles some days. There is no question that this was caused by the vaccines. The only question that remains is will it ever disappear.
I have fibro and notice that many of the women in forums are healthcare workers, so this makes sense!
Hi the same thing has happened to me, I've only worked in healthcare for over a year and I've had the 3 hep b vaccines followed by a booster as didn't have enough immunity. The same time my health has just got steadily worse I can't walk any distance without being in pain and the next day getting post exercise malaise which is disabling as I'm in pain and to fatigued to do anything or even care. My first dr ignored my visits but I kept on as knew there was something wrong I have since been diagnosed with CFS with fibromyalgia I feel there could be a link as I'm a mess cut hours down to 22.5 but still can't cope with those as I'm a mess the 48 hours after. The list for both CFS and fibro was basicly a list off my daily life (every symptom ) I never had pain like it and it come from no where My life is a daily struggle and dull because off the fatigue as I'm to tired. I am going to mention this to the OH at work and see what they think as I've gone from being relatively fit as walked everywhere to feeling 100 years old and the brain fog makes me look like I'm not firing on all cylinders and it has been an embarrassment and quite frightening at times. Keep me posted as I am interested


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Antioxidant Improves Behavior in Autism

Antioxidant could treat behavior problems in children with autism

Behavior problems in children with autism are a frequent occurrence, and they can have a significant negative impact on a child's ability to adjust and function well at home, school, and in other social settings. Although treatment with drugs is one way to manage behavior problems in autism, another may be a common antioxidant.

Irritability is common in children with autism

The antioxidant is N-acetylcysteine (NAC), which is used both as a prescription drug and as a dietary supplement. In the former category, the Food and Drug Administration (FDA) approved NAC as a treatment of acetaminophen overdose. Clinical studies have shown that NAC can treat other toxic conditions as well, including drug-induced liver toxicity and toxicity from chemotherapy and radiation therapy.

The potential benefits of NAC in children and adolescents with autism was the focus of a recent study led by researchers at Stanford University and the Cleveland Clinic. The children were randomly assigned to take either a placebo or NAC daily for 12 weeks. Four evaluations were conducted throughout the study.

At the end of the study, the investigators found that irritability was significantly reduced in children who had taken NAC. The supplement also was well tolerated and associated with few side effects.

Why does NAC work in autism?
NAC is the precursor (substance that is present before or leads to another) to glutathione, a potent antioxidant, produced by the body, that helps control other antioxidants and is a key player in the antioxidant defense system. NAC helps restore and maintain levels of glutathione and thus protect brain cells, and it may also reduce the excitability of the glutamate system. Glutamate is a neurotransmitter in the brain that has a role in learning and memory.

NAC was chosen as a potential treatment for irritability and its related symptoms because of two ideas about autism: that it may be caused by an imbalance between antioxidants and oxidants, and that the glutamate system may not function properly in people with autism.

According to lead author Dr. Antonio Hardan, "Data from this preliminary trial suggest that NAC has the potential to be helpful in targeting irritability in children with autism." The study did not determine how NAC worked to improve irritability nor if NAC could be helpful in improving other symptoms of autism.

Other treatments for behavior problems in autism
In 2006, the Food and Drug Administration approved the antipsychotic drug risperidone (Risperdal(R)) for the treatment of irritability associated with autistic disorder, including temper tantrums, rapidly changing moods, and self-injury. That was the first time the FDA had approved any medication for treatment of children and adolescents with autism.

Risperidone is associated with significant side effects, however. Approximately two-thirds of patients experience drowsiness, while about half have an increase in appetite and more than 20% experience insomnia, increase in salivation, fatigue, upper respiratory illness, tension, and anxiety. Less common side effects include abdominal pain, vomiting, indigestion, and giddiness.

Subsequently, the antipsychotic drug aripiprazole (Abilify) was approved for the same use, and a number of studies have been published on the use of this drug in young people with autism. In a new report from Texas A&M University, investigators presented the results of two 8-week, double-blind, placebo-controlled studies of aripiprazole on the quality of life in the treatment of irritability associated with autism.

A total of 316 children and adolescents (age 6-17 years) participated in the studies. Overall, participants who took aripiprazole scored significantly better on emotional functioning, social functioning, and cognitive functioning than did individuals who took placebo.

Side effects associated with aripiprazole include headache, weight gain, increase in appetite, nervousness, drowsiness, dizziness, heartburn, constipation, diarrhea, and pain in the arms, legs, or joints.

NAC for irritability in autism?
This new pilot study was a first step in discovering whether NAC will be added someday to the treatment arsenal for autism. More studies of this antioxidant are needed to determine its impact on behavior problems in autism spectrum disorder.

Hardan AY et al. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biological Psychiatry 2012 Jun 1; 71(11)
Varni JW et al. Effect of aripiprazole 2 to 15 mg/d on health-related quality of life in the treatment of irritability associated with autistic disorder in children: a post hoc analysis of two controlled trials. Clinical Therapeutics 2012 Apr; 34(4): 980-92

Image: Morguefile

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Children of Mothers Working Full Time Have Positive Outcomes

Many women, when faced with the decision on whether to work or not after the birth of a child, feel guilty for choosing to go back to work. Some research has not been favorable toward women who either need to or want to return to the workforce. But a new study, conducted at Columbia University should give all working mothers a sigh of relief – mothers who go back to work full time within a year of giving birth did not do any damage to their children’s well-being.

Overall Effect of Maternal Employment on Child Development is Neutral

The study, called "First-Year Maternal Employment and Child Development in the First 7 Years", was conducted by three Columbia professors: Jeanne Brooks-Gunn, a child development specialist; Wen-Jui Han, an associate professor of social work; and Jane Waldfogel, a professor of social work and public affairs.

The professors tracked the development and family characteristics of more than 1000 children seven and under from 10 different parts in the US who were a part of the National Institute of Child Health and Human Development Study of Early Child Care. In addition to family relationships and household income, they assessed each child’s vocabulary, reading ability and academic test scores. Teachers and parents provided information on the child’s behavior.

Read: Children of Working Mothers More Likely to Lead Unhealthy Lifestyles

Infants raised by mothers with full-time jobs scored somewhat lower on cognitive tests and the deficits persisted into the first grade. But that negative effect was offset by several positive factors.

Overall, the researchers found that working mothers had better mental health, were able to build healthier relationships within the family and boosted the household income – all of which aided the child’s development. They were also more likely to have higher-quality childcare outside the home, benefiting the children further.

Working mothers also showed greater “maternal sensitivity”, or responsiveness toward their children, than stay-at-home moms.

Read: Maternal Affection Provides Lifetime Benefits

Children whose mothers worked under 30 hours a week benefited the most because they benefited from the positive aspects without losing out on parental attention and interaction. In some instances, children of mothers who worked part time during the first year were less likely to develop behavioral problems.

Professor Waldfogel said, “The findings reflect what I think many working mothers would say, which is that they have balanced all the different considerations and they feel that they are doing the best thing for their families overall.”

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Autism Risk Tied To Genes Influencing Brain Cell Connections

Ruzanna Harutyunyan's picture

In three studies, including the most comprehensive study of autism genetics to date, investigators funded in part by the National Institutes of Health have identified common and rare genetic factors that affect the risk of autism spectrum disorders. The results point to the importance of genes that are involved in forming and maintaining the connections between brain cells.

"These findings establish that genetic factors play a strong role in autism spectrum disorder," says Acting NIH Director Raynard Kington, M.D., Ph.D. "Detailed analysis of the genes and how they affect brain development is likely to yield better strategies for diagnosing and treating children with autism."

Autism spectrum disorders (ASD) comprise a group of disorders with core symptoms that include social interaction problems, poor verbal and nonverbal communication and repetitive behaviors. These disorders range from severe (autism) to mild (Asperger’s syndrome), and in total affect some 1 in 150 American children, about three-quarters of whom are boys. Researchers theorize that the social parts of the brain are underdeveloped in ASD.

"Previous studies have suggested that autism is a developmental disorder resulting from abnormal connections in the brain. These three studies suggest some of the genetic factors which might lead to abnormal connectivity," says Thomas Insel, M.D., director of NIH’s National Institute of Mental Health (NIMH).

The studies were funded in part by the NIMH, the National Institute of Neurological Disorders and Stroke (NINDS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute on Deafness and Other Communication Disorders (NIDCD) and the National Center for Research Resources (NCRR), all components of NIH.

All three studies were genome-wide association studies, which are undertaken to find clues about the causes of complex disorders. Typically, these studies involve scanning the genome — the entire set of DNA — for small differences between people who have a disorder and people who do not.

The largest study, reported in Nature, involved more than 10,000 subjects, including individuals with ASD, their family members and other volunteers from across the U.S. The study was led by Hakon Hakonarson, M.D., Ph.D., a professor at the University of Pennsylvania School of Medicine and director of the Center for Applied Genomics at The Children’s Hospital of Philadelphia. Among other principal investigators on the study were Gerard D. Schellenberg, Ph.D., also a professor at the University of Pennsylvania School of Medicine; and Daniel Geschwind, M.D., Ph.D., a professor at the University of California, Los Angeles and director of UCLA’s Center for Autism Research and Treatment; and Margaret Pericak-Vance, Ph.D., a professor at the University of Miami Miller School of Medicine and director of the Miami Institute for Human Genomics, who also led an independent study that generated similar results.

Major funding for Dr. Hakonarson’s work came from The Children’s Hospital of Philadelphia. Dr. Pericak-Vance’s work was supported in part by the Hussman Foundation. The DNA samples came from a repository called the Autism Genetic Resource Exchange (AGRE), and from subjects recruited at clinics in Philadelphia, Miami, Los Angeles and other sites. AGRE is run by Autism Speaks, with partial support from NIMH.

Previous studies of twins with ASD, other children with ASD and their relatives provided evidence of a strong genetic contribution. Yet until now, only a few genetic risk factors had been identified, and most of those turned out to be rare, with unclear significance for ASD in the general population. Researchers came to realize that the genetics of ASD is complex.

"There are going to be many genes involved in causing autism," says Dr. Hakonarson. "In most cases, it’s likely that each gene contributes a small amount of risk, and interacts with other genes and environmental factors to trigger the onset of disease."

In their large study, Dr. Hakonarson and his colleagues found several genetic variants that were commonly associated with ASD, all of them pointing to a spot between two genes on chromosome 5, called CDH9 and CDH10. Both genes encode cadherins – cell surface proteins that enable cells to adhere to each other. The researchers also found that a group of about 30 genes that encode cell adhesion proteins (including cadherins and neurexins) were more strongly associated with ASD than all other genes in their data set. In the developing brain, cell adhesion proteins enable neurons to migrate to the correct places and to connect with other neurons.

In a second study, Dr. Pericak-Vance completed an independent search for small genetic variants associated with ASD, in collaboration with Jonathan Haines, Ph.D., of Vanderbilt University Medical Center in Nashville. Published in the Annals of Human Genetics, the study provides a striking confirmation that ASD is associated with variation near CDH9 and CDH10.

"We are starting to see genetic pathways in ASD that make sense," says Dr. Pericak-Vance.

Finally, in a third study, reported in Nature, Drs. Hakonarson and Schellenberg led a search for genes that were duplicated or deleted in individuals with ASD. In the rare cases where those variations occurred, many tended to affect genes involved in cell adhesion. Others tended to affect genes involved in the ubiquitin-proteasome system, a cellular waste disposal system that probably affects the turnover of adhesion proteins at the cell surface.

Previous, smaller genetic studies reported a connection between male-only autism and CNTNAP2, a type of neurexin. Together, the three new studies suggest that genetic differences in cell-to-cell adhesion could influence susceptibility to ASD on a large scale. Dr. Hakonarson and his colleagues are planning an even more extensive genome-wide association study to gain a more complete picture of the genes and gene interactions involved in ASD.

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My son has ASD, and I was fascinated to read about this article and the research involved in this study. However, ASD/autism is not a disease - it is a disorder.