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YIA 5 Splicing of HDAC7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation
  1. B Zhou,
  2. A Margariti,
  3. Y Hu,
  4. Q Xu
  1. Cardiovascular Division, King's College London, BHF Centre, London, UK

Vascular smooth muscle cell (SMC) proliferation has an indispensable role in the pathogenesis of vascular disease, but the mechanism is not fully elucidated. The epigenetic enzyme histone deacetylase 7 (HDAC7) is involved in endothelial homeostasis and SMC differentiation but it is unknown whether it could have a role in SMC proliferation. In this study we sought to examine the effect of two HDAC7 isoforms on SMC proliferation and neointima formation. We demonstrated that overexpression of unspliced HDAC7 (HDAC7u) could suppress SMC proliferation through downregulation of cyclin D1 and cell cycle arrest, while spliced HDAC7 (HDAC7s) could not. SiRNA-mediated knockdown of HDAC7 increased SMC proliferation and induced nuclear translocation of β-catenin. Further experiments showed that only HDAC7u could bind to β-catenin and retain it in the cytoplasm. Reporter gene assay and reverse transcription PCR revealed a reduction of β-catenin activity in cells overexpressing HDAC7u, but not HDAC7s. Deletion studies indicated that the C-terminal region of HDAC7u is responsible for the interaction with β-catenin. However, the addition of amino acids to the N-terminus of HDAC7u disrupted the binding, further strengthening our hypothesis that HDAC7s does not interact with β-catenin. The growth factor PDGF-BB increased the splicing of HDAC7 while simultaneously decreasing the expression of HDAC7u. Importantly, in an animal model of femoral artery wire injury, we demonstrated that HDAC7 expression was elevated in a time-dependent manner at both mRNA and protein levels. Knockdown of HDAC7 by siRNA in the injured vessels aggravates neointima formation in comparison with control siRNA. Immunostaining for Ki67 of neointimal lesions displayed that proliferating cells were significantly increased in the vessel wall of HDAC7-siRNA treated group. Thus, our findings demonstrate that splicing of HDAC7 modulates SMC proliferation and neointima formation through β-catenin nuclear translocation, which provides a potential therapeutic target in vascular disease.

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Jennifer Prudenti

Life Transitions/Personal Development Specialist

You are reeling from a recent loss and are mourning your loved one. It feels like you’re drowning in all the wonderful memories that were created. It’s devastating and you feel lost.

You keep asking yourself “What do I do now?” or “How do I even begin to move forward?”

Let’s process the grief and help you navigate the healing process. Then we’ll work together to manage any current challenges you’re facing.

Moving forward, I will be there to help you create the next chapter in your life and with guidance and accountability your story will have a happy ending.

You feel lost and your sense of security has been taken away.

You’re mourning the “death” of your relationship.

Sadness, guilt and feeling like a failure – these are just some of the emotions that have been haunting you lately.

Either way, you don’t know how to move forward and you’re not sure what the future holds.

I’ll help you work through the emotions that may be holding you back and together we’ll create a plan of action that will enable you to reestablish a sense of security and rebuild your ideal life.

Retired/Empty Nester

You thought you’d be happy and excited at this stage in your life, but you’re actually feeling a bit lost and scared.

You’ve had these long standing routines and responsibilities that have kept your mind busy and that have filled your days. Now you have way too much free time on your hands and you don’t know what to do with it.

Should you downsize?

Should you focus on a new endeavor that feeds into your passion?

It all feels so overwhelming. Let’s start with a thorough self-exploration to determine your current priorities.

Then, we’ll map out a step-by-step plan that will get you back on point and loving life again.

College Student

You’re about to embark on a new chapter in your “story” and it mostly excites you, but it’s also a bit scary.

For the past eighteen years or so you’ve been cared for primarily by your parents and now you’re going to have to fend for yourself.

You’re afraid that you may not be able to juggle all of it – get a job, maintain good grades and live on your own.

Let’s get you organized, create some smart goals and action steps for you to take.

I’ll help you achieve a new level of confidence in yourself and you will emerge feeling independent and on track to make the most of your college experience.

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text:
Feb 2011
Conjunctions creak, the adverbs ache,
nouns bear more than they can take.
Verbs are screaming for Ben-Gay
while pronouns atrophy away.

Adjectives have lost their bite,
possessives just give up the fight.
The subject's upset, naught agrees,
which weakens metaphoric knees.

Contractions all together moan;
the objects better left alone.
Ah, life is at a frightful stage
when poets and their poems age.
"The Minister of Silly Poems will see you now." :P
2-9-2011 JMF
Joel M Frye
Written by
Joel M Frye  Jurassic Park
(Jurassic Park)
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Deceased Bee A3 Photographic Print

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Deceased Bee A3 Photographic Print by Wolf & Whale
Deceased Bee A3 Photographic Print by Wolf & Whale
Deceased Bee A3 Photographic Print by Wolf & Whale
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The product includes x1 UNFRAMED print - the attached framed version is for promotion purposes only

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Photographic/Fine Art Prints are printed on high quality photographic paper, as specified in the product description

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Laplace Transfer Function

In this topic:

The Laplace transfer function device implements a linear device defined in the frequency domain by a Laplace transform. For example the Laplace transform ???MATH???\frac{1}{s+1}???MATH??? defines a first order low pass filter while ???MATH???exp(-s)???MATH??? defines a 1 second delay.

The SIMetrix Laplace transfer function device features two different methods of implementation, namely "lumped network" and "convolution". The lumped network implementation is fast and efficient and may be used for transfer functions that can be represented in polynomial form. The convolution method is more general purpose and can model a wide range of transfer functions. High performance is achieved by using a fast FFT-based convolution method.

User Interface

Selecting the menu Place > Analog Behavioural > Laplace Transfer Function brings up the following dialog The operation of the various controls is described below.

Definition See Laplace expression
Delay Adds delay in seconds. Requires convolution method. Equivalent to multiplying transfer functions by ???MATH???exp(-delay.s)???MATH???
Frequency scale factor Multiplier for frequency
Device type
Transfer function Expression defines

Impedance V/I Two terminal device, expression defines

Admittance I/V Two terminal device, expression defines current/voltage.
Input Input configuration for transfer function
Output Output configuration for transfer function
Implementation See Implementation
Convolution Options Convolution size. Increase this value to increase the upper frequency limit. This will slow down the simulation and increase memory consumption. Memory usage for a single device is approximately ???MATH???96*2^N???MATH??? bytes where ???MATH???N???MATH??? is the value entered here. Note that memory is partly shared for multiple devices. The upper frequency is of the order of ???MATH???2^{N-1}/T???MATH??? where T is the simulation time. So for example, with a simulation time of 1ms and N=15, the upper frequency limit will be in the region of 16MHz. Higher frequencies will be gradually attenuated. As well as increasing memory consumption, higher values of convolution size will slow the simulation. This does not become significant until N exceeds about 17 to 18 but increases markedly for higher values.

The Advanced Options tab displays the following:

Error control Configures time-step control algorithm. For rapidly changing inputs the time step must be kept small to retain good accuracy. The parameters entered here control this mechanism.
Diagnostics Check box to enable some diagnostic run-time messages. These provide information on the extraction of the impulse response.
Impulse extraction

Parameters controlling extraction of the impulse response.
Try all methods All methods attempted in

Analytic Attempt analytic method only
Inverse FFT Attempt inverse FFT method only
Stehfest Attempt Stehfest method only
Size of inverse FFT as power of 2 Using a longer inverse FFT to extract an impulse response can increase the accuracy of the results especially if the impulse response decays slowly

Laplace Expression

The Laplace expression defines the behaviour of the device in the frequency domain. For example '1/(s+1)', defines a simple single pole low-pass filter. The expression may contain arithmetic operators and a number of functions as described in the following sections. Be aware that not any expression is physically realisable; for example 'exp(s)' defines a negative delay, that is a device whose output responds to an input in the future.

+ - * / ^
where \^ means raise to power. For lumped network implementation, the power must be an integer. Non-integral powers may be entered for convolution implementation.

Any decimal number following normal rules. SPICE style engineering suffixes are accepted.

s Variable

This can be raised to a power using \^, for example s^2. If the power is an integer between 0 and 9 the \^ may be omitted. For example: s2 is the same as s^2.

The following functions may be used in convolution mode only.
Function Syntax Description
sqrt(x) ???MATH???\sqrt{x}???MATH???
exp(x) ???MATH???e^{x}???MATH???
ln(x) ???MATH???\log_e(x)???MATH???
log10(x) ???MATH???\log_{10}(x)???MATH???
sin(x) ???MATH???\sin(x)???MATH???
cos(x) ???MATH???\cos(x)???MATH???
tan(x) ???MATH???\tan(x)???MATH???
acos(x) ???MATH???\cos^{-1}(x)???MATH???
asin(x) ???MATH???\sin^{-1}(x)???MATH???
atan(x) ???MATH???\tan^{-1}(x)???MATH???
sinh(x) ???MATH???\sinh(x)???MATH???
cosh(x) ???MATH???\cosh(x)???MATH???
tanh(x) ???MATH???\tanh(x)???MATH???
asinh(x) ???MATH???\sinh^{-1}(x)???MATH???
acosh(x) ???MATH???\cosh^{-1}(x)???MATH???
atanh(x) ???MATH???\tanh^{-1}(x)???MATH???
atan2(x,y) ???MATH???\tan^{-1}(\frac{y}{x})???MATH???
pow(x,y) ???MATH???x^y???MATH???

Filter response functions

Filter response functions may be used in both lumped network implementation and convolution implementation.

These are described in the following table:

Function Syntax Filter Response
BesselLP(order, cut-off) Bessel low-pass
BesselHP(order, cut-off) Bessel high-pass
ButterworthLP(order, cut-off) Butterworth low-pass
ButterworthHP(order, cut-off) Butterworth high-pass
ChebyshevLP(order, cut-off, passband_ripple) Chebyshev low-pass
ChebyshevHP(order, cut-off, passband_ripple) Chebyshev high-pass
order Integer specifying order of filter. There is no maximum limit but in practice orders larger than about 50 tend to give accuracy problems.
cut-off -3dB Frequency in Hertz.
passband_ripple Chebyshev only. Passband ripple spec. in dB.

Lookup tables

The frequency response of a system may be defined in tabular form using lookup tables. The lookup table consists of a sequence of values arranged in triplets. Each triplet is in the form ???MATH???frequency, value1, value2???MATH??? where ???MATH???value1???MATH??? and ???MATH???value2???MATH??? define the magnitude and phase in various ways as described below.

There are five variants of the lookup table as described below:

Function Name value1 value2
Table dB phase in degrees
Table_M magnitude phase in degrees
Table_R dB phase in radians
Table_MR magnitude phase in radians
Table_RI real part imaginary part

Table_M(0.01,1,30,  1,1,30,  10,0.1,30,  100,0.01,-30)

The above defines a response with a gain of 1 and a phase shift of 30 degrees from 0.01Hz to 1Hz. From 1Hz to 10Hz the gain falls from 1 to 0.1 with the phase shift remaining at 30 degrees. From 10Hz to 100Hz the gain falls from 0.1 to 0.01 and the phase changes from 30 to -30 degrees.

In real life it is not possible to implement a characteristic with the above behaviour as it is non-causal. However, it can be implemented if a suitable delay is added to the characteristic. The delay may be added in the Define Laplace Transfer Function dialog box in the Definition section - see the Delay entry. Alternatively it may be added to the Laplace expression using ???MATH???exp(-delay.s)???MATH???. E.g:

Table_M(0.01,1,30,  1,1,30,  10,0.1,30,  100,0.01,-30) * exp(-s*2)

The above adds a 2 second delay.

For ease of reading, each triplet in the table may be placed on a separate line by prefixing each line with a '+' character. E.g.

+ 0.01,		1,		30,
+ 1,		1,		30,
+ 10,		0.1,		30,
+ 100,		0.01,		-30)

Interpolation Between defined frequency points, the Laplace transfer function finds the magnitude and phase using interpolation. The interpolation is performed logarithmically on the magnitude data. Values outside the table frequency range are defined by their respective end points.

For the above example the magnitude and phase are shown below:

Parameters (defined with .PARAM) may be used in Laplace expressions but currently only if convolution implementation is selected.

For the lumped network implementation you can use parameters in the underlying simulator device if you define the expression in terms of the numerator and denominator coefficients. Refer to the S-domain Transfer Function Block in the Simulator Reference Manual for further details.

Device type

Transfer function Expression defines output/input.
Impedance V/I Two terminal device, expression defines voltage/current.
Admittance I/V Two terminal device, expression defines current/voltage.

Describes the method the simulator uses to implementation the Laplace expression. There are two choices:
Lumped network The Laplace transform is implemented using a network of integrators.
Convolution The Laplace transform is implemented by convolving the impulse response of the Laplace transform with the input signal.
See below for further details.

Lumped Network

The diagram below shows the configuration used for a third order network. This method can implement a quotient of polynomials in the s variable and any expression that can be reduced to a quotient of polynomials. For such expressions it is fast and efficient.

This method cannot implement expressions containing arbitrary functions such as square-root or exponentials. Such Laplace expressions must be implemented using the convolution method.

This is a general purpose method and can implement a wide range of Laplace transforms.

In the frequency domain, a linear system may be represented by: \[ Vout(s) = Vin(s).f(s) \] where ???MATH???f(s)???MATH??? is the transfer function.

In the time domain the same system may be represented by: \[ Vout(t) = Vin(t) \ast f(t) \] Where ???MATH???f(t)???MATH??? is the impulse response of ???MATH???f(s)???MATH??? and ???MATH???\ast???MATH??? is the convolution operator.

This method is challenging to implement as simple convolution applied to simulation data in its raw form is an ???MATH???\mathcal{O}(n^2)???MATH??? algorithm. This means that the number of computations required at each step is proportional to the square of the number of steps. In practice this becomes unacceptably slow when there are more than about 10000 time steps.

SIMetrix overcomes this performance limitation by using an FFT based fast convolution method with a computation speed of ???MATH???\mathcal{O}(n\log{}^2n)???MATH???. Although dramatically faster, this algorithm requires data to be presented to it at fixed-interval steps which has the effect of placing an upper frequency limit. The actual upper frequency limit can be arbitrarily increased by increasing the number of steps (the value of ???MATH???n???MATH???) at the expense of speed and the memory consumed. In practice the default settings work well in most applications and give good performance and accuracy.

To perform the convolution, the simulator must also extract the impulse response of the Laplace transform. SIMetrix has three methods to do this:
Analytical Matches the Laplace transform to known analytical solutions. For example ???MATH???\frac{1}{\sqrt{}(s)}???MATH??? has the impulse response of ???MATH???\frac{1}{2.\pi\sqrt{t}}???MATH???. SIMetrix will automatically detect this and other known Laplace transforms.
Inverse FFT Calculates the inverse Fourier transform of the Laplace expression. This is a general purpose method that can be applied to a wide-range of Laplace transforms. However, it has the condition that the impulse response must decay to zero during the time interval.
Stehfest method A method to calculate the inverse Laplace transform. Sometimes this method works for slowly decaying transforms that fail with the inverse FFT method.

Impulse Response

Problems with Impulse Response Extraction

For the convolution method an impulse response of the Laplace transfer function must be extracted. As mentioned above, three methods are attempted. The inverse FFT method and Stehfest methods are approximate in nature and for this reason, the result from each method is tested. If the test fails the impulse response is rejected and another method is attempted. If all methods fail the simulation will abort.

Transfer functions that decay slowly are likely to fail the inverse FFT method as this method requires that the impulse response decay to zero or nearly to zero. If the Stehfest method also fails, the problem can sometimes be resolved by increasing the inverse FFT size. This increases the duration over which the inverse FFT is evaluated so providing a longer time to decay.

In many situations the impulse response extraction fails because the transfer function is non-causal. This means that it has a response in negative time. Non-causal transfer functions can be made causal by adding a delay.

Impulse Response Cache

The impulse response is cached to speed up subsequent simulations with the same response. The cache is located here:

C:\Users\<login-name>\AppData\Roaming\SIMetrix Technologies\SIMetrix810\LaplaceCache

where <login-name> is the name used to log in to your system. This can be deleted at any time. The cache is size limited to 250Mbytes by default. This can be changed using the option variable LaplaceCacheSizeMBytes. Type 'Set LaplaceCacheSizeMBytes=nnn' at the command line to set a new value.

Impulse Response Analytical Extraction

The impulse response analytical extraction attempts to match the transfer function to one of the following patterns. The parameters ???MATH???a???MATH???, ???MATH???b???MATH???, ???MATH???c???MATH??? etc represent constant values.

Laplace expression Impulse response
???MATH???a???MATH??? ???MATH???a.\delta(t)???MATH???
???MATH???a/(b.s)???MATH??? ???MATH???a/b???MATH???
???MATH???a/\sqrt{b.s}???MATH??? ???MATH???a/\sqrt{2.\pi.b.t}???MATH???
???MATH???a/(b.s+c)???MATH??? ???MATH???a/b.e^{-c/b.t}???MATH???
???MATH???a/\sqrt{b.s+c}???MATH??? ???MATH???a*e^{-c.t/b}/\sqrt{b.\pi.t}???MATH???
???MATH???\sqrt{a/(b.s+c)}???MATH??? ???MATH???\sqrt{a}*e^{-c.t/b}/\sqrt{b.\pi.t}???MATH???
???MATH???{\displaystyle \frac{a}{b.s^2+c.s+d}}???MATH??? ???MATH???{\displaystyle \frac{-(e^{-t/2(\sqrt{p^2-4q}+p)}-e^{t/2(\sqrt{p^2-4q}-p)}}{\sqrt{p^2-4q}}}???MATH???

???MATH???p=c/b???MATH??? and ???MATH???q=d/b???MATH???
???MATH???a.e^{b.s}???MATH??? ???MATH???a.\delta(b+t)???MATH???
???MATH???a/(b.s^c)???MATH??? ???MATH???{\displaystyle \frac{a.t^{c-1}}{b.\Gamma(c)}}???MATH???
???MATH???{\displaystyle \frac{a.s^2+b.s+c}{d.s^2+g.s+f}}???MATH??? ???MATH???{\textstyle [\frac{-(e^{t.arg2}-e^{t.arg3})*(-p.u+2q+u^2-2v)}{2arg1} - \frac{ (u-p)(e^{t.arg2}+e^{t.arg3}) }{2}+\delta(t)]\frac{a}{d}}???MATH???

???MATH???p = b/a???MATH???

???MATH???q = c/a???MATH???

???MATH???u = g/d???MATH???

???MATH???v = f/d???MATH???

???MATH???arg1 = \sqrt{u^2-4v}???MATH???

???MATH???arg2 = -arg1/2-u/2???MATH???

???MATH???arg3 = arg1/2-u/2???MATH???

???MATH???{\displaystyle \frac{a.s+b}{c.s^2+d.s+f}}???MATH??? ???MATH???{\displaystyle \frac{a}{c}.\frac{(2q-u)(arg2 - arg3) + \sqrt{u^2-4v}(arg3 + arg2)}{2\sqrt{u^2-4v}}}???MATH???

???MATH???q = b/a???MATH???

???MATH???u = d/c???MATH???

???MATH???v = f/c???MATH???

???MATH???arg2 = e^{t.(\sqrt{u^2-4v}/2-u/2)}???MATH???

???MATH???arg3 = e^{t.(-\sqrt{u^2-4v}/2-u/2)}???MATH???

???MATH???{\displaystyle \frac{a.s+b}{c.s+d}}???MATH??? ???MATH???{\displaystyle \frac{e^{-d.t/c}(b.c-a.d)}{c^2}+\frac{a.\delta(t)}{c}}???MATH???
???MATH???{\displaystyle \frac{\sqrt{a.s+b}}{\sqrt{c.s+d}}} ???MATH??? ???MATH???(\alpha.(I1(\alpha.t)-I0(\alpha.t)) + \delta(t)).e^{-\beta.t}.Y???MATH???

???MATH???Y = \sqrt{a/c}???MATH???

???MATH???\alpha = (d/c-b/a)/2???MATH???

???MATH???\beta = (d/c+b/a)/2???MATH???

I0 and I1 are Bessel functions

The analytic matching algorithm will attempt to match partial expressions as well as the whole expression if they are combined by addition, subtraction or multiplication. For example:

will be matched to the product of ???MATH???1/(s+1)???MATH??? and ???MATH???exp(-s)???MATH???. Respectively these have impulse responses of ???MATH???e^{-t}???MATH??? and ???MATH???\delta(1+t)???MATH??? and those two impulse responses will be convolved to yield the final result. Note that this only succeeds if all partial expressions can be matched analytically.

To exploit this method, ensure that the expression is entered in a manner that keeps each partial expression distinct. For example, the following would be matched correctly:

as this would be seen as the two partial expressions ???MATH???1/(s+1)???MATH??? and ???MATH???1/(s+2)???MATH??? each of which can be resolved analytically. The final result would be obtained by convolving the two impulse responses.

However the following mathematically identical expression would not be matched:

The analysis algorithm does not attempt to decompose denominator products so this will not be recognised analytically. The above would be extracted using inverse FFT which would usually be successful but might not be if the run time is considerably shorter than the time constant.


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How can we help?

Users who donate or have donated through a Rallybound site are able to create an account with which they can view transaction history and manage recurring donation plans in their user profile section (see more). Additionally, with their ability to log in, donors have a quicker path to register if they wish to do so (see more).

Administrators can see which donors have accounts and which don't in the Contacts and Donors grid, under the column "Has Account".

Creating an Account

There are various ways through which a donor account can be created. Those include:

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Donors creating accounts is not listed as an activity in the Activity stream.

Post-Donation Registration

For post-donation registration options, please click here.

By default, a link that allows the donor to create an account is included in the below-listed confirmation emails:

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When the donor clicks the link in the email, they are directed to a page on which to create a password, at which time their account is created. The user will receive an email confirming their account.

The placement of this link or even whether it should be included in the donation confirmation email can be managed in the Admin Panel, under Email > Auto Responders. The link is represented by the placeholder "Create_Account_Link", which is available in the Misc section of the placeholders popup. Additionally, the placeholder is wrapped in an "'if' statement" to ensure it doesn't appear for donors who already have accounts. When editing the link, it is important to keep it wrapped in its current "'if' statement", which ensures it only appears as applicable. The text block in question is below. To add it to your donation emails you can copy it from here and paste it into the Source view of the email editor.

{% if Create_Account_Link -%}Would you like to view and manage your donation history?
Click here to create your account.

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The text of the donor account created email can be edited in the Auto Responders tab as well, in the Donor Account Creation template.

Additionally, by default, all recurring plan auto responders include a link for the donor to manage their recurring plan. When this link is clicked, if the donor has no account, they are redirected to a page where they are prompted to create one. This link is indicated in the auto responder WYSIWYG editor with the placeholder {{ Recurring_Donation.Recurring_Manage_URL }}.

Administrator Created Accounts

Administrators can create accounts for donors by locating their donor record in the Admin Panel (this can be done either through the search function or in the People > Donors tab), then click "Create Account" at the top. The administrator will be prompted to create a password for the donor, after which the account will be created.

The donor will receive an email confirming that their account has been created, which by default includes a reset-password link, where they should create a new password of their own. This email can be edited in Email > Auto Responders > Admin Created Donor Account.

To create accounts, the administrator requires Edit permission for donors in their security role.


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Cannabis courses, research spring up at colleges and industry is taking note

Cannabis courses, research spring up at colleges and industry is taking note

Editor’s note: A version of this story appeared earlier on Marijuana Business Daily.

Both hemp and marijuana businesses are taking careful note as professional cannabis courses and programs spring up at universities and other educational institutions across the country.

Examples include Northern Michigan University, Doane University in Nebraska, the University of Denver and University of California at Davis, with colleges offering a huge variety of cannabis-focused four-year undergraduate degree programs, certification classes and even graduate degrees.

Cannabis businesses are watching this educational trend because:

  • There is a shortage of people highly knowledgeable about advanced cannabis business, technology and legal/compliance topics, so graduates from the programs could potentially prove ideal candidates for employee recruitment.
  • As well-established universities expand offerings around cannabis education, some industry watchers believe this could help to further destigmatize the marijuana industry – and possibly help nudge federal cannabis reform forward.
  • The courses help to underline the expanding employment opportunities within all sectors of the state-legal cannabis industry across the country and the world.

Higher education history lesson

Just a few years ago, little evidence existed of cannabis programs in U.S. higher education – other than the one federally approved marijuana research center at the University of Mississippi.

While some higher education institutions are now researching hemp due to easing of restrictions following the 2018 U.S. Farm Bill, the research center at Ole Miss remains the only federally approved center of its type to actually grow marijuana and directly investigate its properties.

This was even as the U.S. Drug Enforcement Agency (DEA) last month said it was moving ahead with plans to expand marijuana research.

The future of cannabis education

Even in states where marijuana is neither medically nor recreationally legal, cannabis programs also are available.

The private Doane University in Nebraska, for example, is offering an online program this fall covering the science, cultivation, processing and regulation of both marijuana and hemp.

Courses are due to start there in November, and 700 people have already enrolled.

The program is dubbed “Cannabis Science and Industries: Seeds to Needs,” and is a professional certificate program designed to meet the demand for educated professionals across cannabis agriculture, processing, wellness and manufacturing sectors.

It is the brainchild of organic chemistry professor Andrea Holmes who, at the end of a sabbatical she used to found two Denver-based cannabis companies, decided she wanted to remain an entrepreneur and also teach about the industry.

“There is such a need for a qualified workforce but many just don’t have the right credentials, and so there needs to be a practical training program for direct application,” Holmes told Hemp Industry Daily.

Industry supporting research

Hemp and CBD companies are also writing checks to sponsor academic research on the plant and its extracts.

Among them is Oregon CBD, which recently announced a $1 million gift to Oregon State University’s Global Hemp Innovation Center to research the plant’s genetics.

Hemp’s new legal status has triggered an explosion of university research activity in hemp.

Often the research is being funded by CBD manufacturers who say the research could lead university partners to validate mountains of anecdotal evidence about cannabidiol’s health benefits.

Local programs, global opportunity

Experts noted the fact that colleges are offering cannabis programs in states where marijuana isn’t legally available reflects the global nature of the industry.

Max Simon, CEO and co-founder of Ventura, California-based Green Flower Media, likened professional cannabis opportunities to the tech industry where students can enroll in programs in Georgia, for example, and get jobs in California.

His firm is a cannabis education platform company that works with higher education institutions on cannabis curriculum.

“There is now training to go globally wherever the opportunities might be in different parts of the world,” he said.

The variety of fields students can focus on offers many opportunities in an industry that is crying out for more informed, experienced and talented people to meet growing demand, Simon added.

“There are educational opportunities in the medical sector, in business, in horticulture and in the legal and compliance sector,” he said.

“There is a shortage of well-trained people. We are still very much in the first inning here, but it is developing.”

Hurdles around cannabis education

The University of California at Davis and its newly formed Cannabis and Hemp Research Center is a good example of the interdisciplinary nature of what the industry can offer.

It brings together research around possible environmental and health impacts, applications for use, social implications and legal and public policy.

Proof of the nascent nature of cannabis programs on campuses, however, is that a common first reaction of college administrators to proposals on such programs is concern it will lead to students using large amounts of marijuana, Simon noted.

“We are still early in the mentality surrounding this plant,” he said.

Holmes at Doane University said it was a real “uphill battle” both within the university and from outside to overcome opposition to her program idea.

“I have spent more time at this university meeting with faculty, the provost, human resources, to defend the program than I have actually putting it all together,” she said.

“There has also been outside pressure telling me it will put me in a bad light, but there are also many, many supporters.”

Barrington Rutherford, senior vice president of community integration at Chicago-based multistate operator Cresco Labs, would like society to eventually recognize the industry as it does other well-established ones that sponsor colleges, citing the business school at Cornell University named after S.C. Johnson & Son, the Racine, Wisconsin-based multinational consumer goods company.

However, it may be some time before a college business school is named after a U.S. cannabis company.

Cornell itself is offering a course this fall – “Cannabis: Biology, Society and Industry” – with a  focus on history, culture, pharmacology, breeding, horticulture and legal challenges associated with cannabis.

“There are major corporations with longstanding relationships with schools,” Rutherford said.

“And the schools are just responding to society.”

Nick Thomas can be reached at [email protected]

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Registered Nurse - Medical ICU Unit - 24 hours per week - 12 hour midnight shift - Henry Ford Macomb Hospital

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Tsugumi Sendo is a heroine in the Fatal Fury video game series. She is a female high school wrestler and one of the two original characters in the game, along with Toji Sakata.

Tsugumi Sendo is a high school student in Osaka who was wrestled by her father Kantetsu from an early age. However, she was ashamed of this, especially after a boy told her that her obsessive woman wrestler was "non-female" and wanted to withdraw from her wrestling training.

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Azureish White Gradient

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If there is any one secret of success, it lies in the ability to get the other persons point of view and see things from his angle as well as your own.
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President, DMQ Partners

Ms. Quinn has executed mapping and pipeline projects which have included senior women, veterans, and people of color for financial institutions, law firms, and consulting firms. Ms. Quinn was VP, Global Head of Talent Acquisition with XL Catlin where she led a global team of talent acquisition professionals and had direct responsibility for offshore operations in Poland and India. She was VP, International Executive Recruiting, First Data where she built systemic and scalable recruiting programs that enabled the organization to meet aggressive hiring goals.

Ms. Quinn was a Managing Consultant with Korn Ferry/FutureStep. She was President of Quinn & Associates, Inc., a boutique search firm. Ms. Quinn was a Senior Manager with KPMG’s Consulting Practice, VP of University Relations and Diversity Recruiting with Citibank and an Analyst at Booz, Allen & Hamilton. She provided unbundled executive search services for Fortune 100 companies. Ms. Quinn was the National Director of Strategic Planning for the Consulting Practice at Ernst & Young. In this capacity, she was responsible for creating firm wide staffing plans and managing the recruiting processes for all professional hires and acquisitions of similar businesses.


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Welcome to Hill Country Birth!

Hill Country Birth (formerly Lovely Hearts Birth) was created to serve the Hill Country community and encompasses my life-long passion for community service and a dedication to continued learning. Offering childbirth education and doula services to pregnant women and yoga classes to people of all ages and abilities, including Integral Yoga®, prenatal yoga, and yoga for chronic pain and arthritis, Hill Country Birth strives to connect people from all walks of life in the Hill Country of Central Texas.

Every birthing mother deserves the best care and support during and after pregnancy. We are here to help provide that support! Providing doula services, childbirth education for pregnant women and their partners, and prenatal yoga, we are here for the women of Hill Country.

This journey into the birth community started for me even before I had children, when I started to explore prenatal options as a yoga teacher in New York City. I finished my pregnancy-specific training in 2009, and have been working with pregnant women ever since. My doula work came next and seemed a natural progression in supporting pregnant women. Since moving to rural Central Texas, I realized there was a need for childbirth education locally that was evidence-based, holistic, and one that valued a woman’s innate ability to birth a child.

We offer yoga classes for various populations throughout Hill Country, including regularly scheduled group classes at the Springs Family YMCA in Dripping Springs. We also offer private classes for one or more students in the comfort of your own home and group classes for corporate events and team-building gatherings.

Whether you are looking to expand your yoga and meditation practice, a doula for your birth or want to learn more about labor and delivery (and what happens after!) so you can have an informed, confident, and conscious birth, Hill Country Birth is here for you.

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National Intelligence Estimate on Pacification
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Measuring Financial Health with the Composite Financial Index

The Composite Financial Index (CFI) is a sophisticated tool designed to help you think strategically about your school's overall financial health and communicate succinctly about it with school leaders. Employed by higher education institutions for decades, the CFI produces a complete picture of your institution's financial strengths and weaknesses in a single score that is based on four underlying core ratios.

To develop the CFI, experts with the Big 4 accounting firm KPMG ran longitudinal models on data from over 250 colleges. From this, the team developed a scoring scale, metric scale and weighing scale. NBOA's work with the CFI is the result of an important partnership with the National Association of Independent Schools (NAIS), in conjunction with CFI co-creator Phil Tahey.

In this class, business officers will learn:

  • The benefits of the CFI and how it can be used to guide strategic conversations and decisions in conjunction with long-range planning.
  • How to calculate the index and other tips you need to use the tool effectively.
  • How the historic trend of your CFI has been affected by past actions and estimate how your current strategic plan will affect the forecasted CFI.

This course is being offered in partnership between NBOA and One Schoolhouse.

Course Schedule

Week 1

Introduction to the Composite Financial Index and the Four Core Ratios

In the first week of the course, you will learn about the genesis and benefits of the Composite Financial Index. You will be introduced to the four core ratios and how they are calculated and used in discussion of the index. Also in this week you will calculate a five-year trend of the core ratios and develop a narrative of the trends and factors/actions the school has taken that are affecting the trends.

Week 2

Calculating the CFI

In the second week of the course you will learn about the strength factors and weighting schema for calculating the CFI and how to calculate your own CFI five-year trend. You will learn how the use of debt in the independent school sphere differs from that in higher education and how debt influences the calculation of your CFI. Students will post a summary of their school’s five - year trend and and whether it validates or contradicts what you know about your school’s financial health.

Week 3

Practical and Strategic Application

In the final week of the course you will learn how to use the CFI in conjunction with your school’s strategic plan. Through an exercise, you’ll forecast your school’s CFI trend for three years and see how your current strategic financial plan will affect your CFI in the future. You will also have the opportunity to map out your introduction of the CFI to other school leadership (HOS, Finance Committee chair, etc.). Then you may either have the conversation with leadership or do a practice-run with other course participants and share feedback on your experience.

SHRM Information

Credit Hours: 6

Category: Business Acumen

NBOA is recognized by SHRM to offer SHRM-CP or SHRM-SCP professional development credits (PDCs). For more information about certification or recertification, please visit

HRCI Information

Credit Hours: 6

Category: HR (Business)

NBOA is a recognized provider of recertification credits. HR Certification Institute® pre-approved this program for credits towards aPHR™, PHR®, PHRca®, SPHR®, GPHR®, PHRi™ and SPHRi™ recertification.

Email or call 202-407-7140

Oct 28 - Nov 15, 2019  Closed

Apr 20 - May 8, 2020  Register

Jun 8 - Jun 26, 2020  Register

Cancellation and refund policies

Group rebate available

Time Commitment

3-5 hours per week for 3 weeks

Learn more about the platform and coursework

Class Size

Up to 35 participants

Recommended Audience

  • Business officers
  • Controllers
  • Business office staff
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text:
Facebook Double down on Anti-Christian Censorship Even After Being Called out by Four U.S. Senators

Featured Story

Isaiah 5:20
Woe to those who call evil good, and good evil; Who put darkness for light, and light for darkness; Who put bitter for sweet, and sweet for bitter!

Facebook Walks Into Legal Trap After Claiming To Be ‘Publisher’ In Laura Loomer Lawsuit

Defiant Speech Nazis at Facebook

For a technology and social media company that grew into a behemoth thanks entirely to the fact that it was founded in the freest, most open society on the planet, Facebook has since adopted a distinctly anti-American posture that alienates well over half the country.

Recently, four U.S. senators — Josh Hawley (R-Mo.), Kevin Cramer (R-N.D.), Ted Cruz (R-Texas), and Mike Braun (R-Ind.) — called out Facebook in a letter over its enduring anti-Christian bigotry and censorship aimed at pro-life activists from Live Action.

“Your company, like Twitter, Google, Pinterest and so many of the other major social media firms in Silicon Valley, has repeatedly been presented with evidence of bias against those with conservative viewpoints, especially on the issue of abortion,” the letter noted.

The senators’ correspondence comes after an Aug. 30 notification from Facebook informing Live Action, which is a leading nonprofit group with the biggest online following in the pro-life movement, that a pair of videos it posted reaffirming the widespread viewpoint that “abortion is never medically necessary” were labeled as “false.”

The notification stemmed from an alleged “fact check” from two abortionists, Drs. Daniel Grossman and Robyn Schickler, both of whom said that the medically necessary claim was “inaccurate” and “misleading.”

In its notification, Facebook informed Live Action that the page of Live Action President, Lila Rose, and any links to liveaction.org would now have “reduced distribution and other restrictions because of repeated sharing of false news.” In other words, Facebook planned to intentionally limit the distribution of Live Action posts even to its own followers, which is a blatant antitrust violation.

Combined, Live Action and its president, Lila Rose, have more than 3 million followers.

“This so-called ‘fact-check’ came as part of a Facebook initiative to combat false news involving partnerships with groups like The Associated Press, FactCheck.org, PolitiFact, and others,” the letter said. “You claim that your fact-checkers are ‘certified’ through the ‘non-partisan’ International Fact-Checking Network.”

Facebook is violating rights — and maybe even the law

In reality, the senators wrote, “Facebook’s ‘independent fact check’ of the Live-Action videos was performed by two pro-abortion activists with significant ties to abortion-rights advocacy organizations, both of whom are paid to perform abortions.

“No reasonable person would describe [either physician] as neutral or objective when it comes to the issue of abortion, yet Facebook relied on their rating to suppress and censor a pro-life organization with more than 3 million followers,” the letter continued, which is a clear violation of the IFCN principle and the social media giant’s alleged commitment to non-partisanship.

They also demanded that Facebook issue a correction and remove “any restrictions placed on the pages of Live Action and Lila Rose.” They also said Facebook, “at a minimum,” must allow external examiner access to internal company documents and procedures while allowing that auditor to question employees and senior officials about said policies. (Related: Girl Scouts now celebrating young girls who push abortion, despite the fact that HALF of all abortions are baby girls.)

Fat chance of that happening without subpoenas and threats of government action, however.

In fact, Facebook doubled down on the censorship, sending another notification to Live Action’s followers that the group was spreading ‘fake news.’

Live Action@LiveAction · Sep 11, 2019Replying to @LiveAction and 11 others

“Thank you to Sens. Hawley, Cramer, Cruz, and Braun for their leadership. The platform should be a place for the free exchange of ideas, not one where only pro-abortion arguments are allowed.” @LilaGraceRose

Full statement: https://www.liveaction.org/ussenate/

View image on Twitter

Live Action@LiveAction

BREAKING: Following this morning’s letter from various US Senators demanding @Facebook rectify this situation, @facebook has just sent ANOTHER push notification our followers claiming that we are spreading “false news”

This is truly unacceptable.

View image on Twitter

3921:17 PM – Sep 11, 2019Twitter Ads info and privacy252 people are talking about this

Mind you, Live Action has previously received disciplinary action from Facebook even though the group accurately reported about the Dublin Declaration, which is a document signed by more than 1,000 OB-GYNs, other doctors, and healthcare experts that indeed, abortion is never a medical necessity

Other conservative news organizations including Natural NewsThe National Sentinel, Big League Politics, and others have reported being censored by Facebook and denied access to their followers — even those that were bought and paid for through marketing efforts — over the platform’s false accusation of reporting ‘fake news.’

Not all social media are as anti-Christian. The Brighteon Video platform is a free-speech zone where pro-life views are welcome.

Sources include: BigLeaguePolitics.com HealthFeedback.org LiveAction.org NewsTarget.comFacebookTwittergoogle_plusShare

1 John 4:3 and every spirit that does not confess that Jesus Christ has come in the flesh is not of God. And this is the spirit of the Antichrist, which you have heard was coming and is now already in the world.

It is now being widely reported that a multi-year crusade against Jack Phillips, the Colorado cake baker who’s been under endless assault by the L.G.B.T. mafia for refusing to bake cakes for homosexual “weddings” and transgender “conversion” parties, is finally out of the Leftists’ crosshairs following a recent decision by the Colorado Civil Rights Commission (C.C.R.C.) to basically stop persecuting Phillips simply because of his faith. But the eye-opening reality is that, despite this small but noteworthy victory, the demonic war being waged against Christians in this country has only just begun.

While we might not be hearing much about Phillips anymore, Christians at large throughout America should expect to feel the heat of escalating hostility against their free speech rights, particularly online. In case you haven’t noticed, censorship on all of the major tech platforms, including Facebook, Google, Pinterest, Apple, Twitter, and Instagram, has been on the rise in a major way in recent years – and one of its primary targets is Christianity and all things associated with it.

You see, the spirit of antichrist, backed by a growing army of mindless L.G.B.T. foot soldiers, is on the move in these final days to destroy all Christians wherever they might be found. And it won’t stop until every last thing that’s good, moral, and right in the eyes of God is completely obliterated from society, using whatever means necessary.

Eliminating internet free speech seems to be the current tactic, as Big Tech has all but completely morphed into an extension of the “deep state” thought police in trying to regulate what people say and share online. One of the latest trends pushing for this abolition of the First Amendment online involves Leftists falsely accusing Christians, conservatives, and other Big Government “defectors” of engaging in “hate speech” every time they express their views – “hate speech” having already been programmed into the minds of the brainwashed masses as being an unforgivable no-no.

By classifying Christianity as “hate,” Leftists hope to abolish it in the name of “tolerance” and “love”

The Southern Poverty Law Center (S.P.L.C.), for instance, a hate group pretending to support “civil rights,” has actually made it a fundamental policy to designate any and all Christian organizations it comes across as “hate groups,” perpetuating the myth that any person or group of people that espouse beliefs contrary to what Big Brother deems acceptable is somehow embodying and perpetuating “hate,” and thus needs to be silenced.

“The SPLC regularly designates Christian organizations as ‘hate groups’ because of their support for Biblical marriage,” reports Bonnie Pritchett for WORLD magazine, noting that a far-Leftist group known as “Change the Terms” has already been tasked with identifying and targeting for elimination all forms of Christian “hate speech” online.

“Cloaked as a bid to purge neo-Nazis and white supremacists from internet platforms, the group admonishes tech companies to ‘combat hate activities while protecting minority voices.’ Its members include the Southern Poverty Law Center and the Center for American Progress.”

Bible-believing Christians already know that, as revealed in the Bible from long ago, antichrists will roam the earth seeking out whomever they can lay their hands on in order to completely devour. In this current day and age, much of the persecution and tribulation being inflicted upon Christians as a result of their faith in Jesus Christ is happening online – through the elimination of all free speech, including speaking directly with others in everyday life, is sure to be next on the chopping block.

“That’s the whole idea. Trying to wear out the saints,” wrote one commenter at CBN News about how the Cult of L.G.B.T. and others often seek to silence Christians by embroiling them in endless legal proceedings. “But we are more than conquerors through Him who loves us.”

Facebook Walks Into Legal Trap After Claiming To Be ‘Publisher’ In Laura Loomer Lawsuit

Facebook may have just stepped on a legal landmine amid an ongoing battle with journalist Laura Loomer – after the Silicon Valley giant claimed in a motion to dismiss Loomer’s lawsuit that it can bar the political activist under their rights as a publisher, according to RT

Notably, Facebook has long defined itself as a tech company which simply provides a platform for users’ free speech – maintaining that they’re a neutral party which is protected from legal repercussions.

“Under well-established law, neither Facebook nor any other publisher can be liable for failing to publish someone else’s message,” reads the company’s motion to dismiss Loomer’s defamation lawsuit – adding that terms like “dangerous” or “promoting hate” cannot be factually verified, and are therefore protected opinions for a publisher according to the report. That said, the company claims it never applied either term to Loomer despite banning her under their “dangerous individuals” policy.

The company may have just stepped on a landmine, however. As RT notes:

Defining itself as a publisher opens Facebook up to lawsuits for defamation and other liability for the content users publish, something they were previously immunized against. All the lies, personal attacks, and smears launched by users going forward can now be laid at Facebook’s feet. That’s a Pandora’s box they might not want to open, legal analyst and radio host Lionel told RT.

Platforms like Twitter, Google, and – until now, apparently – Facebook are protected from the legal consequences of their users’ speech by section 230 of the Communications Decency Act. Facebook even makes reference to section 230 later in its motion, suggesting that it is trying to have its cake and eat it too.

Lionel points out that Facebook could go back to life as a platformif it was willing to sacrifice its usefulness to those in power by allowing some political speech to reach users and blocking the rest. –RT Source

Our government has been overthrown. As evidenced by Trump’s capitulation on the border, his recent servitude to the GMO industry and his acquiescence to the warmongers, our President has been compromised. Our liberties are being eliminated one by one. Gun confiscation is next. The Constitution is gasping its last breaths. Our borders are destroyed and our culture has been turned upside down by every perversion known to man.

Sources for this article include: CBN.com NaturalNews.com WNG.orgFacebookTwittergoogle_plusShare

StevieRay Hansen
Editor, HNewsWire.com

Let Me Make This Abundantly Clear. (I Am Apolitical) While I Have a General Distaste for Politicians No Matter the Party They Belong To, I Am Unashamedly Politically a Bible Believing Conservative Christian. I Have a Severe Distrust of Government. I Believe It Is the Most Inefficient and Ineffective Way to Accomplish Most Things. While I Strongly Disagree with Liberals/Progressives and Conservative on Most Political Issues, and While I Believe Liberals/Progressives and Most Politicians Are Terribly Misguided and Naive About What Big Government Will Eventually Result In, I Strive to Not Question Their Motives. at the Same Time, While I Find Myself in Agreement with Conservative Politicians on Some Issues, I Do Not Believe Electing Republicans Is the Answer to Everything. for Me, Very Sadly, the Main Difference Between Republicans and Democrats Is How Quickly They Want to Drive the Car Towards the Cliff. Simply Put, I Do Not Believe the Government Is the Solution for Everything. I Do Not Place Any Faith, Trust, or Hope in Any Politicians to Fix What Is Wrong with the World. “Come Lord Jesus!” (Revelation 22:20)

Our government has been overthrown. As evidenced by Trump’s capitulation on the border, his recent servitude to the GMO industry and his acquiescence to the warmongers, our President has been compromised. Our liberties are being eliminated one by one. Gun confiscation is next. The Constitution is gasping its last breaths. Our borders are destroyed and our culture has been turned upside down by every perversion known to man.

Education is useless without the bible (Daniel Webster)

Usually, the Lord doth no great thing for or against his people, without giving warning of it before it comes.

John Wesley who said that what we tolerate in our generation, will be embraced by the next. Wesley is 100% correct! We are living in sick times.

Evil Exists So Spiritual Warfare Becomes Necessary!

  1. Corinthians 4:8-11 New King James Version (NKJV)
  2. We are hard-pressed on every side, yet not crushed; we are perplexed, but not in despair; 9. persecuted, but not forsaken; struck down, but not destroyed— 10. always carrying about in the body the dying of the Lord Jesus, that the life of Jesus also may be manifested in our body. 11. For we who live are always delivered to death for Jesus’ sake, that the life of Jesus also may be manifested in our mortal flesh.

Satan has power over (LGBTQE-TRANS PEOPLE). The “sons of disobedience” referred to in Ephesians 2:2 are those who have not trusted Christ as Lord and Savior (cf. Acts 26:18; 2 Corinthians 4:4; Revelation 13:12). The demons are also under the rule of Satan (Matthew 12:24), and one of his titles is “prince of demons” (Matthew 9:34). Satan has a kingdom (Matthew 12:26) and a throne (Revelation 2:13). Satan is called a prince because he is a ruler and possesses the power to manifest evil in the world through influencing people and commanding demons.

HNewsWire- “All political language is designed to make lies sound truthful and murder respectable.” Just look at some of our modern-day examples: torture is “enhanced interrogation techniques”; murder is “collateral damage”; the aggression initiation of war is a “pre-emptive strike”; the theft of taxpayers’ money is a “bailout”, and the theft of depositors’ money in a bank is a “haircut” or “bail-in”.In a blatant example of Newspeak, the New World Order controllers (through the psychiatric DSM V) have tried to rename pedophiles as “minor-attracted persons” and redefine pedophilia as “sexual orientation”. This makes no sense since sexual orientation has to do with gender, not age, with whether you are attracted to males or females, not how old they are. There are even organizations (like B4UAct.org) which are claiming that pedophiles are being unfairly stigmatized for their feelings!

If homosexuality has been posed as healthy, good and normal, in the face of overwhelming evidence to the contrary, so can pedophilia. Pro-pedophilic articles are making their way into academia.

The Cult of LGBTQE-E for EVIL and is often a cover for child-molesting perverts

Tagged Under: abuse, children’s health, gender-confused, gender issues, gender madness, the left cult, LGBTQE, un-godly Mob, Lunacy, mutilation, transgender, Child molesting perverts LGBTQE- E For Evil, drag queens, perverts

Unfortunately, not all alternative sources are reliable, even some Major Christian (and I use Christian loosely) news sources have been corrupted. They will NOT tell the truth. They just parrot the deceptive narratives perpetrated by those who currently control our government and media. Even those who are honestly trying to present the truth can miss it sometimes. There is so much deception out there. In these last days, you must be wise as serpents and gentle as lambs. It is no time to sleep or slumber. Diligence and vigilance are required. It is critical that you think for yourself and not be a Lemming.

Tagged Under: abortionabortionistbiasCensorshipconservativesdiscriminationFacebookFact Checkfake newshypocrisyinformation controlJosh HawleyletterliesLive Actionpartisanshippro-abortionpro-lifepropagandasenatorssuppressed newsTed Cruzthought controlUS Senate

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Lucky Stone Couple Bracelets | Holistic Bear

Questions? Message us at 424-501-4395 close

Lucky Stone Couple Bracelets

$39.99 USD $9.99 USD
Metal Color

Lucky Stone Stacked Collection

Lucky stone is the type of material that is designed specifically for couples.

Meaning: Lucky stones are full of positive energy, passion, desire, and good emotions. When two lovers wear them together, the positive energy from both the bracelets combines and the after-effects can be felt in the relationship. Not only do they bring tons of happiness, but they also help create everlasting bonds between two soulmates.

Relationships, whether they're with friends, family, or a significant other, are meant to be kept in strong bonds. Take time to remind yourself of this special person and keep them close to you forever :).

The Stacked Collection is a collection of two of our bracelets sold as a package deal.  We went through All of our collections, and picked out different varieties of bracelets that we thought matched very well.  Since "Stacking" multiple bracelets AKA Wearing multiple bracelets is very popular, we wanted to make a whole collection upon this, and make the two bracelet deals even better than if you bought them each separately.

Before wearing these bracelets, simply close your eyes and make a wish.

  • Made with unique lucky stone beads
  • Bracelet diameter is 18-19cm.
  • Special material proven to bring increased amounts of positivity into life

In each order you will receive 2 bracelets, unless you've purchased single pieces

Domestic Shipping (USA):  ALL USA Shipping is FREE!  Your Item/s will be packaged and shipped within 5 days of ordering. Keep in mind speciality items mail takes 12-20 Business days (Most of the time closer to 12).

International Shipping: Your Items will be packaged and shipped within 5 days of order. We do ship worldwide! Please be patient and note that delivery times will vary depending on your location. Also, customs may charge an extra varying fee upon arrival. Hope this explains what you need to know about Int. Shipping.

Returns Policy

You may return most new, unopened items within 30 days of delivery for a full refund. We'll also pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.).

You should expect to receive your refund within four weeks of giving your package to the return shipper, however, in many cases you will receive a refund more quickly. This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days).

If you need to return an item, simply login to your account, view the order using the 'Complete Orders' link under the My Account menu and click the Return Item(s) button. We'll notify you via e-mail of your refund once we've received and processed the returned item.

We can ship to virtually any address in the world. Note that there are restrictions on some products, and some products cannot be shipped to international destinations.

When you place an order, we will estimate shipping and delivery dates for you based on the availability of your items and the shipping options you choose. Depending on the shipping provider you choose, shipping date estimates may appear on the shipping quotes page.

Please also note that the shipping rates for many items we sell are weight-based. The weight of any such item can be found on its detail page. To reflect the policies of the shipping companies we use, all weights will be rounded up to the next full pound.

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Adam Sandler

Film News: Closing Night of 2019 Cinepocalypse in Chicago is ‘Airheads’ on June 20, 2019

CHICAGO – Has it been a week already? Has it been 25 years already? The 2019 Cinepocalypse Film Festival is drawing to a close with the film “Airheads” (1994), celebrating its 25th Anniversary. The All-Star cast, in their younger days, includes Brendan Frasier, Steve Buscemi, Adam Sandler, Chris Farley, Joe Mantegna and Judd Nelson. Director Michael Lehmann (“Heathers”) will appear on behalf of the film at the historic Music Box Theatre in Chicago, with a Closing Night after party to follow. For more information and tickets, click here.

Film Review: Drac Pack Still a Drag in ‘Hotel Transylvania 2’

CHICAGO – For the younger set unable to experience the mystique of Dracula, Wolfman and Frankenstein in their original creations, “Hotel Transylvania 2” may prove to be an introduction to the legendary bloodsucker and his band of movie monsters – and for that Adam Sandler deserves a stake through his heart.

Film Review: Instead of Geeky Greatness, Adam Sandler Sucks the Soul Out of a Badly Miscast ‘Pixels’

CHICAGO – The epitome of an idea that far outweighs its execution, “Pixels” is a bittersweet blunder that had all of the elements to be geeky great but ends up being cheesy mediocre. I could literally feel its potential for 105 minutes, but the $88 million film ultimately fails to realize it.

Blu-ray Review: Chris Rock’s ‘Top Five’ is Pretty Interesting

Top Five

CHICAGO – Chris Rock isn’t a huge writer/director, but when he does make a film, it’s an event to consider. For example, he made black president tale “Head of State” long before then-senator Barack Obama was even considered for the real-life role, and whether behind the stand-up mic or in an interview, he’s a voice to be reckoned with.

Film Review: Adam Sandler’s ‘The Cobbler’ a Historical, Stupefying Disaster

The Cobbler, 2015

CHICAGO – The newest Adam Sandler film that doesn’t feature him dressed like a chubby middle schooler is really bad, but in a special way. Similarly, it is an instant classic in the legacy of bizarre disasters, a footnote in writer/director history that must be witnessed to be fully understood.

Blu-ray Review: Stale Screen Culture Drama ‘Men, Women & Children’

Men, Women & Children with Kaitlyn Dever

CHICAGO – In “Men, Women & Children,” director Jason Reitman not-so-audaciously reflects onto viewers their world of silent screens and awkward impersonal interactions. As many stories (“Don Jon,” “Disconnect”) have taken on the torch of showing how we are, gasp! — connected to the world yet disconnected from those close to us — Reitman’s tale is just another one for the batch.

Slideshow: Writer, Actress Bella Thorne for New Book ‘Autumn Falls’

| Image 1 of 3 |
Bella Thorne for her novel ‘Autumn Falls,’ on November 15th, 2014.

CHICAGO – 2015 may prove to be huge year for the actress, model and young adult author Bella Thorne. The 17-year-old has many irons in the fire, including roles in several upcoming films this new year. The author in her was in Chicagoland last November, appearing at Anderson’s Bookshop in Naperville, Ill., on behalf of her new novel in the “Autumn Falls.”

Film Review: Schizophrenic ‘Top Five’ is Evolution for Chris Rock

CHICAGO – Chris Rock wants you to take him seriously, so he has made a comedy with inconsistent laughs, and a nod towards the weird fishbowl lives that today’s celebrities endure. It’s a rare film where the last part is stronger than the first few acts, a mishmash that is “Top Five.”

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"Just wanted to let you know that I held off on buying a pair of cans until I was able to afford the Sennheiser HD600. Best audio purchase IMO. Thanks for writing all those great articles on your site; I wouldn’t have thought of saving for the HD600s without them."
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"They arrived today (the m40x), epic f*****g headphones I cannot believe this magic. This power. I mean, it's neutral in all aspects! Thank you so much and congratulations from Mexico. Maybe I don't speak English very well but I can understand and write too. You're the God of the reviews without an inclination in your own taste of the product. Thank you so much Stuart."
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"I just received my mdr-v6 in the mail. They are so much better than my wireless Sony headphones that cost the same… lol. Thank you for helping me with the purchase!"
"I just want to say, Stuart, that it’s refreshing to read your honest reviews on headphones. While yours are not the only good reviews, there are a lot of fanboys pushing products and it’s not all that hard to tell which reviews are somehow paid for through commercialism.

It took me many hours of research before I was able to find the painstaking, excellent work you’ve presented. Your work far exceeds the norm on the web and I really appreciate you giving your valuable time and energy to help me and others reach a difficult decision. You rock!"
"Finally, I got my 7506 and happy that I own this classic pair after our very long conversations that answered every bit of detail in my questions to the last one which left no question mark on my mind.
You really care and are a very helpful person and I feel very glad that I came across this site before making my own decision.
Hope to see this site getting only better in time. Cheers!"
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"Hey thanks a lot for taking your time to answer my questions man <3. Your videos and articles really helped me a lot."
“Hey man, just wanted to say that I found your site a couple of days ago while looking for some mic comparisons for the AT2020. I’m a rookie at this studio stuff, and barely beginning (still buying the hardware part, lol), but man… I gave up searching on google when I discovered your site, ’cause honestly, I haven’t found a place with more resources and info into this stuff than your site. You rock man. Your site rocks. Please, for the sake of newbs like me just starting out, keep up the hard work, ’cause it sure as heck has helped me a LOT, and will probably help me even more when I get into the ‘real’ stuff. Glad to see that there’s people around sharing their experiences and knowledge for the ‘greater good’ of strangers which they may never know. (Crazy, huh?) Oh, that’s the beauty of the internet, for sure! Thanks again buddy! See ya!”
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"Thanks for the response Stu, I totally enjoy your reviews! I have gained as much or more knowledge and insight from your site as I have from any other I have seen.
I am a true fan, and although I have most certainly perused and totally enjoyed your headset reviews, when I upgrade to a fancier planar headset I’ll be asking your advice for sure. The HE400S may be my first planar, but it won’t be my last!! Thx again…"
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This site is genuine example for how professional sites about audio equipment should look like. It is a true pleasure roaming your site, keep up the great job you’re doing here.
THANKS for all the assistance in choosing the HD700s, now the task, is an amp/dac." Sincerely,
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"I fell upon this website while trying to make a decision on what headphones to treat myself too. Stu and I swapped numerous emails, full of my questions and his knowledge. Having spent hours reading through all of his reviews, I have become far more knowledgeable in the area and ultimately with his help have settled on a pair of cans I have truly fallen in love with (grado sr325e).
Keep up the good work buddy, I’ll be spreading the word about this fantastic guy and the huge resources on his website to all my friends."
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"Thank you so much for your extremely in-depth reviews. I am so glad I stumbled upon your site. It was a Godsend for you to answer all the questions anyone would have. You do have a way of breaking down tech speak so we Gronks can understand in common language. Your insight is so valuable. Thank you."
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"Thanks for your help by the way! That guide (The Best Headphones for Gaming) was the best I had found. Was a breath of fresh air having things easily spelled out and rated on a fun vs. competitive scale. I just wanted some good headphones, since I myself am not an audiophile."
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"I wanted to post this here so hopefully you see it. We were talking in the comments section of your HD25 review about whether to get those or the V6's. I bought the V6's and love them even for casual listening. I like them better than my HD 598's in that regard actually.
I’m a huge fan of your website and YouTube channel my dude, thanks so much for the help. It’s great that you actually engage with the people that follow you and help them out. Keep up the great work! You provide a great service for beginners like me. Thank you so much!"
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LEGO Ideas

Tool TimeThe ninety’s have been a special time within the pop culture zeitgeist. The music was wonderful, movies have been box-office hits and TV was in its prime.

Richard Karn, now 56, graduated from the University of Washington with a drama degree and received his position on Home Improvement by a stroke of luck. Though the present had already cast Borland’s character, Karn met a casting agent while answering a site visitors quotation in courtroom and was brought on board after the original alternative (Stephen Tobolowsky) had to drop out. It was the first major role for Karn, who remains to be appearing largely in household comedies. After Home Improvement, his most distinguished function was as a game show host, together with a 4-yr stint on Family Feud.

The oldest of Tim and Jill’s sons, Brad was best known for his relative recognition and athletic potential, together with a proficiency at soccer. He struggled academically at occasions however nonetheless managed to earn a school scholarship near the top of the sequence. Despite getting in trouble on a number of events and typically clashing with his dad and mom, Brad additionally received along properly with Tim by common pursuits reminiscent of auto restoration.

Patricia Richardson, now sixty one, earned a BFA in acting from Southern Methodist University and spent some time acting in performs. She picked up quite a few minor TV roles within the Nineteen Eighties before Home Improvement. She next appeared as Dr. Andy Campbell in Strong Medicine as well as a recurring role as Sheila Brooks on The West Wing. She has continued acting in a few motion pictures and is lively in an organization searching for a treatment for progressive supranuclear palsy.

Prior to Home Improvement, Hindman was best recognized for portraying Bob Reid in over 450 episodes of Ryan’s Hope. He was a villain in the unique The Taking of Pelham One Two Three as well as The Parallax View. Hindman had fewer roles after Home Improvement ended, with a couple of guest roles on Law & Order and an element within the 2001 film Final. He died of lung most cancers in December of 2003 at the age of 61.


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All three judges agree and so do we.  The next American Idol could be from the Capital Region. Yes, her audition last night was that good!

Last night during the audition round of American Idol, a teenager from Cohoes received a standing ovation from all three of the judges and may have become the early front-runner for the show.  16-year-old Madison VanDenberg wowed Luke Bryan, Katy Perry and Lionel Richie en route to a unanimous 'ticket' to Hollywood drawing comparisons to the first ever winner of Idol.

Katy Perry immediately mentioned the 'goosebumps' she felt when VanDenberg took to her piano and sang Speechless from Dan + Shay telling the Cohoes native that she reminded her of Kelly Clarkson.  Luke and Lionel agreed marveling at the fact that the local standout was only 16!

All three judges sang her praises adding that she may in fact be the next American Idol.

While it's still very early in the competition, Madison killed her audition and earned a trip to Hollywood.  Singing competition shows are always fun, but it's much more exciting when you have a local singer competing; especially one as talented as Madison VanDenberg.


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Theatre History Podcast # 33

Rediscovering the Victorian Theatre at the Alexandra Palace with James White

When it opened in the 1870s, the Alexandra Palace, or “Ally Pally,” was a massive entertainment complex, meant to serve as “the People’s Palace.” Over the course of its lifetime, it’s seen multiple fires, served as an internment camp during the First World War, and been the site of one of the first television broadcasts. It’s also home to a spectacular and historically-significant Victorian theatre. James White, our guest this week, is a curator working on restoring the complex, as well as the theatre.

vintage event poster
Ad for Alexandra Palace Theatre, featuring a scene from The Show's the Thing, starring Gracie Fields, c. 1933.

drawing of theatre
The Alexandra Palace Theatre in 1875, rebuilt after the 1873 fire.
vintage photo of theatre
The theatre being used as a storage facility in 1967.
Photo of theater
The theatre in 2014, prior to its restoration.

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Thoughts from the curator

This podcast aims to introduce listeners to the artists, scholars, and archivists who are working to bring the history of performance to life. We hope that, by listening to this show, you’ll learn about exciting new performances, fascinating books, and valuable repositories of knowledge, all of which will help you better understand theatre’s history.

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