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on June 20, 2008 at 3:16 PM, updated June 20, 2008 at 4:14 PM
Mike Myers and Jessica Alba smile in "The Love Guru," not realizing the reviews are out.

I was at a studio publicity junket today, for the fun family adventure "Journey to the Center of the Earth," due next month. And there was lots to talk about -- including the eye-popping 3D effects, and Brendan Fraser's cornering of the summer-adventure market. (August brings his second epic fantasy, a new "Mummy" movie.)

But first, it seemed, there were two questions that everyone wanted to ask me.

The first was, invariably, "Did you see `The Love Guru'?" And the second -- said in the kind of shocked-but-fascinated way people ask about bad divorces or public meltdowns -- was a hushed "Is it really as bad as I think?"

To which the first answer is "Yeah."

And the second is "Hell, yeah!"

A quick look at the Rotten Tomatoes review site, for example, shows the film with a 15% "fresh" rating -- meaning that 85% of reviews have been negative.

The Daily News called it "atrocious, idiotic." Salon called it "almost completely joyless." Variety dubbed it "relentlessly juvenile." And they weren't even the worst reviews (including some sites which answered Myers' dirty jokes with dirty words of their own).

Of course, one critic in Montreal -- there's always one -- said that the star was "so spirited, good-natured and having a blast" that "it's almost impossible not to be won over." But that cumulative 15% grade puts the film just one scant point ahead of "College Road Trip" and "Superhero Movie" as one of the worst-reviewed films of the year.

And the movie earns it.

But what I also detected at the studio junket today was a certain whiff of schadenfreude. It is no secret that, for years, Myers has been a difficult person to work with, backing out of contracts at the last minute or demanding ridiculous perks. And for years people have put up with it, for the same reason they always put up with that behavior: his movies made money.

But his "Cat in the Hat" film was horrific, and this feature is even worse. In fact, apart from his various "Shrek" voiceovers, Myers last hit was half-a-dozen years ago, in "Austin Powers in Goldmember." (And isn't that one you can't wait to see again?) And so more than a few people seem to be actually happy to see him foundering now.

Well, "The Love Guru" was supposed to be all about karma.


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Hunterdon County's Churches Plan Ash Wednesday Services

Craig Turpin By Craig Turpin Hunterdon County Democrat
on February 20, 2009 at 10:22 AM, updated February 20, 2009 at 10:34 AM

Many area churches have scheduled special services for Ash Wednesday, Feb. 25. This marks the beginning of the Lenten season.

Here is information on some of the services:

l Alexandria First Presbyterian Church, 141 Little York-Mount Pleasant Road, Holland Township, at 7 p.m. The Rev. Dennis Jones will lead the congregation in the Litany of Penitence. The imposition of ashes will be available. 996-4333

l Bethlehem Presbyterian Church, 2 Race Street, Union Township will hold a soup supper at 6 p.m. and Ash Wednesday service at 7:30. 735-5733
l First United Church of Christ, 48 Church St., Milford, will celebrate the imposition of ashes and communion at 7:30 p.m. 995-4827
l Kirkpatrick Memorial Presbyterian Church, 37 John Ringo Road, Ringoes, will hold a service, including communion, at 7:30 p.m. 782-1177
l Our Lady of Lourdes Church, 390 Route 523, Whitehouse Station, has scheduled services for 8:30 a.m., 12:10, 4:30 and 7:30 p.m. 534-2319
l Readington Reformed Church, 124 Readington Road, will serve soup at 6:30 p.m., and the Rev. Catherin Gumper will lead a ecumenical service at 7:00 p.m. 534-2077

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Sustainable Jersey awards grants to 32 towns for green projects

Matthew Cortina/Independent Press By Matthew Cortina/Independent Press Independent Press
on October 12, 2012 at 2:51 PM, updated October 12, 2012 at 2:52 PM
community_garden_readington.JPGView full sizeGrants were awarded for community garden projects. Pictured here is a community garden in Readington Township.

Nonprofit Sustainable Jersey awarded $200,000 in grants to 32 New Jersey towns looking to run community-based sustainability projects.

The grants were awarded on Sept. 28 through the Sustainable Jersey Small Grants program funded by the PSEG Foundation

Four towns — Hoboken, Princeton, Island Heights and Middle Township — received the top $20,000 green grant. The grants will be used to fund “proposed projects that provide sustainable solutions to everyday challenges,” according to a press statement.

"The impact that these projects will make in New Jersey is incredible," said Pam Mount, Chair of the Sustainable Jersey Board of Trustees. "Aiding towns and Green Teams to achieve their sustainability goals by funding green initiatives will have a ripple effect that will benefit us all."

Princeton, for instance, will use their grant to support a program that turns curbside waste into compost recycling. Hoboken will direct their grant towards building and maintaining curbside gardens that reduce flooding and create safer pedestrian crossings.

There were also eight $10,000 winners and 20 $2,000 grant recipients.

In Hunterdon County, West Amwell received a $10,000 grant and Frenchtown received a $2,000 grant to protect easements near stream, river and forest areas.

In Morris County, Mount Olive received a $10,000 grant for their community gardens project and Chester Borough and Township received $2,000 for their Community Visioning Project.

Cranford received a $2,000 grant and was the only municipality in Union County to receive one.

Launched in 2009, Sustainable Jersey is a nonprofit, nonpartisan organization that supports community efforts to reduce waste, cut greenhouse gas emissions, and improve environmental equity.

More than two thirds of New Jersey municipalities have partnered with Sustainable Jersey to begin addressing local energy and consumption needs.

Visit Sustainable Jersey’s website for the full list of 2012 green grant recipients.

The grants will be awarded at a luncheon in Atlantic City on Nov. 13.


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Feeling a lot like an old car

Emily Cattuna/For the Jersey Journal By Emily Cattuna/For the Jersey Journal The Jersey Journal
on August 14, 2012 at 3:00 AM, updated September 24, 2012 at 10:50 AM

The only way to collect memories is to grow older, but growing older is sometimes very painful and scary.

I remember a now-deceased lady who was infuriated that her doctor said she was getting like an old car; rattling, rusting and falling apart.

Although it wasn't funny and in poor taste it was . . . unfortunately . . . true. If I compare myself to an old car, I reached the "trade in" stage a few weeks ago.

Let us compare:

I guess the old car and I have about the same amount of creeks, rattles moans, groans and rust.

I sputter and wheeze starting up. (getting out of a chair).

My finish has lost its luster and shine and needs a touch up (makeup) daily.

My grill no longer glistens. It's dull and yellowed with a few teeth missing.

My "bumpers" once stood high, proud and round now sag and droop close to the ground.

My headlights are no longer glowing bright. They're out of focus and dim, especially at night.

My maximum speed is slow and the "crank" is now in the front seat.

My tires, laden with corns and calluses, have lost traction; I wobble, slip and bump into things.

My whitewalls look like road maps transected with blue veins.

My air conditioner and my hot flashes are uncoordinated.

Even my "spare tire" has bumps and bulges.

My trunk is really full of "junk."

So, haul out the tow truck, my good days are gone. But, be careful, I must warn you . . . My radiator leaks and my exhaust backfires.

That's what I remember . . .

You may contact EMILY CATTUNA at or by writing to The Jersey Journal, 30 Journal Square, Jersey City, NJ. Read her column and offer your comments at


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Knicks links: Media reacts to Jason Kidd's retirement

He hit over 50 percent of his field goals in November, but the rest of the 2012-2013 season got progressively worse for Jason Kidd. (Jesse Johnson-USA TODAY Sports)
Alex Raskin, By Alex Raskin, The Star-Ledger
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on June 04, 2013 at 9:44 AM, updated June 04, 2013 at 9:49 AM

Jason Kidd never specified the exact reason for his retirement. It could have been the fact that he's 40 or that he's played 19 seasons. It could have been the 10-game scoreless streak he endured in the playoffs, but whatever the reason, Kidd knows it's over.

"I think it is the right time," Kidd told's Ohm Youngmisuk after retiring on Monday. "When you think about 19 years, it has been a heckuva ride. Physically, I want to be able to participate in activities with my kids so it has taken a toll. It is time to move on and think about maybe coaching or doing some broadcasting.

"[Agent] Jeff [Schwartz] and I and my family had been talking this past weekend," Kidd continued. "We talked a lot and we felt it was the right time to move on and so we notified the Knicks. They were kind of taken aback. We told them [earlier] that I wanted to come back and play. But this weekend was when we got a chance to relax [and really think about it]. It is the right thing to do."

Youngmisuk, like many local writers, covered Kidd as a member of the New Jersey Nets; and for most in this area, that's how he'll be remembered.

The Star-Ledger's Dave D'Alessandro:

Over seven tedious years, which pretty much covered Clinton's two terms, the Nets averaged 28.8 victories per season.

Then J-Kidd showed up in East Rutherford.

And instantly, the Nets went to back-to-back NBA Finals.

Right, happens all the time.

"I was thinking of that today," said Rod Thorn, the man who brought Kidd to Jersey on July 18, 2001. "I remember when Larry Bird went to the Celtics, they took a huge jump up -- it's happened with a few special players. But we went from 26 wins to. . . .what, 52 as soon as Jason arrived? That's a pretty incredible jump. And that was almost entirely Jason."

Mike Lupica of the New York Daily News:

You go back and look at all the significant trades in American professional sports over the last 20 years, and you do not find many – or any – that changed the culture of a franchise the way Jason Kidd changed the culture for the New Jersey Nets, until then one of the lost-boys franchises anywhere.

And before long, because of the power of his passing and his game and his talent and his imagination, the Nets were somehow in two NBA Finals. One, against the Lakers, they had no chance, and got swept. The other, though, against the Spurs, that one Kidd will always believe his team could have won and should have won before it lost in six games. That is the one, even though Kidd will never say this, he will believe the Nets could have won if he hadn't just been playing for the team, but coaching it as well.

Newsday's Al Iannazzone—another longtime Nets writer who now covers the Knicks—was given a perfect quote to sum up Kidd's career.

"I came in the league as not a shooter, not a scorer," Kidd said. "My game was to play defense and make my teammates better. The most important stat to me was that left column -- winning. Nothing else matters."

Kidd helped his teams reach the playoffs 17 consecutive years. His leadership was a big key as the Knicks won 54 games and earned their first Atlantic Division title in 19 years. He averaged 6.0 points, 3.3 assists, 4.3 rebounds and 1.6 steals in 76 games as a starter and reserve.

Pacers assistant Brian Shaw—who grew up with Kidd in Oakland and is a candidate to become the next head coach of the Nets—believes the legendary passer will be back in the NBA soon.

"I'm sure that's not the way he wanted to go out as a player," Shaw told Frank Isola of the New York Daily News. "I'm sure that had to be real tough because Jason is such a competitor. But I still think he's got something left in the tank whether it's as a player, coach or executive."

The Bergen Record's Steve Popper, who covered Kidd with the Nets and the Knicks, agreed, suggesting that the former California star will end up in a front office.

The decision ran contrary to what Kidd indicated to the team the day after the season ended in his exit interview, but it didn't come as a surprise to those who knew him. Last week Kidd said that he would make his decision and it wouldn't have to do with money — he's walking away from the remaining two years and $6 million on his three-year contract with the Knicks.

He has spoken of coaching, but also has indicated that it might be a path to his true goal: working in a front office for an NBA team.

The truth may ultimately be that it was too difficult to stay in basketball shape at 40. It's one thing to play with friends, but it's another to do it professionally as your body succumbs to middle age.

"He told me recently he wanted to leave the game when he still enjoyed it," a Kidd confidant told Marc Berman of the New York Post. "It was the hardest year he's had mentally and physically, especially the second half of the season. You can tell he was tired. No specific injury. Just harder to keep his body in shape."

In other Knicks news:'s Tony Williams sees the Kidd signing as a success for the Knicks: "And regardless of how his tenure ended, Kidd's brief time in New York should be seen as a success, simply because of the great value he gave the Knicks on his mid-level contract, as well as providing the franchise with supreme on-court leadership and talent that helped awaken a once-dormant and increasingly irrelevant franchise from it's decade-long malaise."'s Ian Begley explained Kidd's retirement and how it affects the Knicks' cap situation: "It doesn't have much of an impact this summer. The Knicks are over the salary cap and will remain so, even with Kidd's $3.1 million salary off the books... Assuming the Knicks re-sign J.R. Smith, they will likely still be taxpayers and over the tax apron. The apron is significant because a team can execute a sign-and-trade if its total salary is below the apron after the trade. (The numbers for next year's luxury tax level and salary cap have not been released yet.)'s Jared Zwerling reported that, as expected, J.R. Smith will opt out of his deal: "The Knicks can re-sign Smith for $4.9 million using the Early Bird exception, with standard raises over four years."


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D'Alessandro: Celtics PG Rajon Rondo set the bar, how will the Heat respond?

Dave D'Alessandro/Star-Ledger Columnist By Dave D'Alessandro/Star-Ledger Columnist The Star-Ledger
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on May 09, 2011 at 5:00 AM, updated May 09, 2011 at 5:35 PM
RONDO ELBOW.JPGRajon Rondo holds his left arm after getting tangled with Miami Heat guard Dwayne Wade as Celtics Kevin Garnett and Ray Allen move in to help him.

WALTHAM, Mass. — The common human reaction is more emotional than rational or cognitive when you see one of your most important guys writhing on the floor, with his arm twisted in some random shape of overdone fettuccini.

Sure, the Celtics know they cannot win this series, or perhaps even another game, without Rajon Rondo. And that thought probably dominated their initial thoughts during his third-quarter elbow crisis Saturday night.

They’re not going to admit that, but they can admit that they are as squeamish as the rest of us, even if it’s a friend in need.

“I was scared,” Jeff Green said of the sight.

“Honestly, when I saw it, I thought he broke his elbow — close-up, it looked as though the bone came out,” Delonte West said.

Actually, it was so hideous that Doc Rivers still hadn’t watched it Sunday — “I fast-forwarded,” the Boston coach said — and Doc isn’t exactly dainty.

Actually, Rivers tried to hide his initial fear with a joke, as he always does: “It alarmed me,” he said of the sight of Rondo’s left arm hanging limply as he played the entire fourth quarter virtually one-handed. “But it was working. Listen, I played with one hand my entire career, so you can do it. And he did it.”

Okay, now consider how all these people would react when their point guard returned to the floor 10 minutes later — after a doctor literally pops the joint back in alignment — and the inspiration they would derive from this singular act of courage, especially with 18,624 screaming their approval of every Rondo movement thereafter.

Sports is a trivial pursuit — we all know that intellectually — but this is one of those uncommon lessons we get this time of year. Never mind how serious a dislocated elbow might be — in most cases, there is ligament and capsule damage that requires surgery, and thankfully the MRI on Rondo came back negative Sunday.

And yes, too often on the sports pages we embellish these moments with a heaping pile of over-egged metaphors and a few snappy references to Greek tragedy.

But the real issue is the effect that Rondo’s return had on teammates, such as West, who looked around the TD Garden, let the vibe puncture both eardrums, and concluded, “When he came back, I said, ‘Well, we definitely have no excuse now.’ ”

Or, as Ray Allen said in gushing tribute, Rondo’s act was merely a reminder that “it’s the time of year when true champions step up.”

Rondo may not be able to play in Game 4 against Miami tonight, and who knows how effective he’ll be the rest of the way. But his ability to return from a stomach-turning injury might have changed the narrative of the series — for more than one day, we mean — and that doesn’t often happen without someone scoring 40 points or getting suspended.

Make no mistake, the Celtics are still a physical wreck. Rondo was said to be in “much greater pain today, with a lot of swelling,” according to Rivers. West has a bruised left shoulder, and is also iffy.

That means the majority of the point guard minutes might go to Carlos Arroyo, a 31-year-old journeyman whose salary is actually being paid for by Miami, which waived him days before Boston picked him up March 5.

But for us, the bigger question is this: How will the Heat react now?

When some people chose Boston to win this series, they always cited the Celtics’ superior toughness and character. So in the aftermath of this demonstration of Boston toughness and character, what effects might this have on Miami?

How does this team view itself now, after Chris Bosh looked embarrassed to admit he was playing with a pinched nerve in his neck (amid widespread tittering in the interview room, by the way)?

“You know, I don’t know,” Rivers said. “They’re a pretty tough group. If it does (affect them), it would be great.”

Perhaps this is a clue: Dwyane Wade, catalyst of the incident that nearly ended Rondo’s season, seemed pretty touchy about l’affaire Rajon on Sunday.

He doth protest too much, in fact: “I’m not answering no question about that. I’m done with that. I’m moving on,” Herr Heat snapped Sunday at Emerson College, after someone asked whether he saw a replay of the incident.

Nobody accused Wade of deliberately trying to hurt Rondo.

But for the record, he clearly hooked his opponent on the way down, and Wade wasn’t exactly trying to break his fall. It looked more like the petulant act of a proud player who hates looking bad, and the Celtics defense was making the Heat look very bad.

It may not happen again. Miami still is the better team — by a significant margin if Rondo plays with one arm the rest of the way.

But if Boston somehow stuns the world, we’ll know where this series turned. And we’ll know the precise moment when Miami recognized as a team that it couldn’t measure up against — physically, mentally and emotionally — despite superior talent.

Dave D’Alessandro:


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Honor Yoga brings peace and fitness to Hamilton

Michele Angermiller/For The Times By Michele Angermiller/For The Times The Times, Trenton
on September 19, 2013 at 7:00 AM, updated September 19, 2013 at 7:08 AM

HAMILTON — Drivers passing Buckley Plaza cannot miss the giant giraffe overlooking Route 130 in Hamilton. But they might not know that behind the ceramic statue, ensconced in the back of the shopping center, is Honor Yoga, a serene studio for a community of people who seek peace and fitness in a hectic world.

On a recent quiet Friday morning, instructor Brian Critchley led a class in the softly lit room. In a calming voice, he guided the students through a series of positions and breathing techniques. The students seemed utterly at ease, but they were clearly getting a workout.

“It’s the best form of exercise,” said Beth Ann Shanks of Chesterfield. Shanks and her husband Edmund joined the studio after a successful run at Weight Watchers.

“We both lost 40 pounds, and then realized that we had to get toned,” she said. “This has been perfect, and the people here are amazing — the instructors, the owners and the members.”

Hamilton resident Sherri Waryasz agreed, saying the studio is like “a second family.”

“I love the atmosphere and the instructors,” she said. “Everyone is so like-minded here.”

Honor Yoga is the realization of a dream for co-founders Melody Appel and Maria Parella-Turco. Each had a passion for yoga, but noticed that outside of a few gym classes in the area, there were limited opportunities for yoga enthusiasts, unless they wanted to drive to Princeton or Pennsylvania.

Appel, a Robbinsville native, said that although gym classes are fine, there was something missing.

“You don’t get the same feeling as being in a studio,” she said.

Their goal was to offer a sanctuary for people in the Hamilton area who shared their passion for yoga, she said.

Once the two women found a space, they got to work setting up an eco-friendly studio, with natural wood used as curtain rods, and washcloths in the restroom to create a “paper-free” environment.

The school offers a range of courses including beginner classes, prenatal classes and family classes, with the aim of creating a no-pressure, inviting atmosphere.

To Appel’s surprise and delight, Honor Yoga’s grand opening in March attracted 150 people, and since then more than 1,000 members have come through the doors, she said.

Edmund Shanks attributed the studio’s success to the openness of Appel and Parella-Turco.

“It’s the classes, it’s the people, and it’s like being in church without being in church,” he said. “The owners have created a community here.”

In keeping with that theme, Appel connected with Ali Tomlinson, a certified health coach who created what she calls the IN-Power method to weight management and whole health. Tomlinson had come to the studio in April to practice yoga herself, but said she quickly “fell in love with the mission of the studio.”

Tomlinson is hosting a Sunday evening “Hungry For Change” workshop series, a dieting workshop designed to shed light on food and lifestyle habits that prevent healthy lifestyles. It kicked off Sept. 8 with a screening of documentary called “Hungry for Change.”

Tomlinson said she is guiding participants with tips on breaking food addictions and controlling weight without dieting, and will have a “clean plate club” designed to teach students how to manage their meals. Appel said the program fits with her studio’s ideals.

“When people get into yoga, they really start to take care of themselves,” she said. “You just want to make healthier decisions.”

Other upcoming workshops include “Laughter Yoga,” to be led by Waryasz on Sept. 28. It promises an interactive experience designed to improve one’s mood and spirits with laughter, exercise, deep breathing, and traditional yoga poses.

Critchley said each workshop and class at Honor Yoga has a common goal of improving the world around us.

“If more people practiced yoga, we would all be nicer to people on Route 1,” he said.

For more information visit or call (609) 414-7171.

On mobile or desktop:

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Newark police capture two suspects on department's most-wanted list

Sharon Adarlo/The Star-Ledger By Sharon Adarlo/The Star-Ledger The Star-Ledger
on February 26, 2010 at 5:12 PM, updated February 26, 2010 at 5:36 PM
McCoy1.JPGMalik McCoy, 29, of Newark
NEWARK - Two men on the Newark Police Department’s most-wanted list were taken into custody in a one-week span, making them the 111th and 112th suspects captured on the list, authorities said.

Luis Vega, 30, of Belleville, who was wanted for a shooting last year, and Malik McCoy, 29, of Newark, who was wanted for robbery while impersonating a police officer, were captured Feb. 16 and Yuesday respectively, said Detective Todd McClendon, a police spokesman.

Vega, also known as "Toniti Vega," is accused of shooting a 25-year-old city woman in the shoulder outside a building on Park Avenue on Nov. 7, McClendon said. A three-month investigation led authorities to Philadelphia, where he was captured by members of the U.S. Marshals Service.

McCoy was arrested in Atlanta Tuesday afternoon by the members of the U.S. Marshals Service and will be extradited to New Jersey, McClendon said. McCoy is accused of impersonating a police officer on March 1, when he and two unidentified accomplices allegedly held a 37-year-old Newark man at gunpoint and took his cell phone and $25 in cash.

The incident happened on Stone Street when McCoy, wearing a Newark police T-shirt and carrying a police-type badge, approached the victim, McClendon said. After the wary victim asked for another form of identification, McCoy allegedly took out a firearm and robbed the man.


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Remembering September 11: Coverage of events in New Jersey

Bart Brooks / Website Staff By Bart Brooks / Website Staff The Star-Ledger
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on September 11, 2013 at 9:15 AM, updated September 11, 2013 at 9:57 PM

Multiple events are being held throughout New Jersey to remember the terrorist attacks of September 11, 2001.

Below is a list of posts highlighting some of these events:

Christie: Every year on 9/11, family members 'relive that awful day'

AT&T removes controversial 9/11 tweet, issues apology

Sept. 11 remembered: Reflections on a day of heartache

Some NYC streets closed for 9/11 ceremonies

Christie orders flags at half-staff to commemorate Sept. 11

Bergen County:

Lt. Gov. Guadagno dedicates 9/11 memorial in Allendale

Cumberland County:

Bridgeton 9/11 commemoration: More than 60 make stair climb (with photos)

Gloucester County:
WTC steel a teaching tool in Washington Township

First responders gather in Mantua park (with photos)

Hudson County:

Secaucus residents join in remembrance of 9/11, honoring six from town who died

Three fallen West New York residents honored at 9/11 ceremony in their hometown

Those lost on 9/11 are remembered during memorial on Jersey City waterfront

Christie appears for 9/11 memorial in Liberty State Park

Photos: The National September 11 Memorial and Museum

Hudson County's municipalities are holding 9/11 memorial services today

Eternal pain of 9/11 families remembered at the Hoboken September 11th Interfaith Memorial Service

Bayonne honors city's fallen at the 9/11 Tear Drop Memorial with a vigil and interfaith ceremony

Hunterdon County:

9/11 Memorial Stair Climb at Hunterdon Medical Center (with photos)

Sept. 11 victims remembered during Clinton ceremony

Middlesex County:

Perth Amboy remembers the fallen (with photos)

Monmouth County:

N.J. town that lost most residents per capita remembers 9/11 with silence

PHOTOS: Union Beach 9/11 Memorial

Morris County:

Images of 9/11: NJ firefighter-photographer remembers gray, silence, shock

Salem County:

Salem County remembers 9/11, unveils monument at new memorial park

Union County:

Honor Guard salutes the fallen at Union County Sept. 11 memorial in Mountainside

Warren County:

Freeholders and first responders remember Sept. 11 at Warren County memorial

Be sure to check back throughout the day to see updates to this post.


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Jersey Shore fishing: Northeaster delivers a knockout

Al Ristori By Al Ristori The Star-Ledger
on October 09, 2013 at 5:33 PM, updated October 09, 2013 at 5:53 PM

The long-lasting northeaster has pretty much knocked out fishing except in the most protected spots such as the Point Pleasant Canal. I gave the surf one last try late yesterday afternoon at Bay Head, when I could still cast metal far enough over the increasing waves to get out to any fish that hadn't already fled to the depths. There weren't any hits, but I got what might be my last exercise on the beach for several days. That was just the beginning of the northeast blow, and it's being predicted to last into Sunday. The only ocean possibilities may be pockets at inlet jetties, especially at Island Beach State Park.
Bob Matthews said party boats didn't sail from Belmar Marina this morning, and it's likely that was the case all along the coast. The Cock Robin from Point Pleasant has already cancelled for Thursday, and anglers should check with skippers before coming down to the Shore.


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NY Giants, NY Jets are a study in contrasts

Paul Needell/The Star-Ledger By Paul Needell/The Star-Ledger The Star-Ledger
on October 25, 2009 at 7:00 AM, updated October 25, 2009 at 5:05 PM
Giants vs. Jets, genericThe Jets and Giants are both coming off losses, but the outlook for the teams is totally different.

Here the local football teams sit, both coming off losses, with their fans anxiously waiting to see what comes next — albeit from vastly different vantage points.

There are the 5-1 Giants, finally brought back to reality by the New Orleans Saints last Sunday at the Superdome. The 48-27 whuppin’ the Saints put on the Giants’ prideful and talented defense was thorough and convincing, no doubt sending Giants Nation into a tizzy and longing for Steve Spagnuolo, the new St. Louis Rams coach no doubt longing for them, too.

The Jets are entirely another matter, losers of three straight after starting the season full of 3-0 bluster. Staring at .500 doesn’t go over too easily when your coach, Rex Ryan, is still talking 1.000. Something has to give.

Thankfully for the Jets and reeling rookie quarterback Mark Sanchez, they will try to right themselves against the Raiders Sunday in Oakland. Then again, we thought the "San-chize" was lucky to be facing the Buffalo Bills at home last Sunday and look how that turned out. The Elias Sports Bureau is still searching for proof he actually threw six interceptions, not just five.

Not so easy, on paper, for the Giants, even though they are at home Sunday night. Their opponents are the Arizona Cardinals, the defending NFC champions who don’t travel East very well but still fling the football around pretty darn good.

Oh, and that guy doing the slinging is Kurt Warner, who should look familiar. He was once the groomer for Eli Manning, way back in 2004. Good job, Kurt — Eli’s won a Super Bowl and Warner came back to life last season to almost turn the same trick for the Cardinals.

So, here the locals are, still taking advantage of flying under the radar while the Yankees steal some attention from them well into October. Maybe even into November.

By which time, the Jets may already be speaking of next year — with bluster, of course. But we don’t really expect that. In today’s NFL, the Jets are good enough to stay mathematically alive for a playoff berth into December, lest the San-chize has a meltdown even his head coach can no longer ignore.

The Giants? Calm down, True Bluers. We have yet to see whether Bill Sheridan’s defense is going to be as ferocious as Spagnuolo’s was, but the offense looks like it can be even more explosive than in the Plaxico Burress days.

Manning is better than ever. Wide receivers Steve Smith, Mario Manningham and rookie Hakeem Nicks, complementing running backs Brandon Jacobs and people’s choice Ahmad Bradshaw, are more than enough ammo to allow the Giants to match up with almost anyone they face.

Even an old friend and still-mighty gunslinger like Warner. Sanchez? He just has to worry about outdueling JaMarcus Russell today. Barring an implosion of Buffalo proportions, Ryan and Co. will be back flapping their gums in no time.

Redskins coach Jim Zorn is safe for the rest of the season and “hopefully beyond,” according to de facto GM Vinny Cerrato, Danny Boy Snyder’s main henchman. Translation: No one Snyder has pleaded with to take over in midseason — Mike Shanahan? Mike Holmgren? Jon Gruden? — would take the job now. Rumors persist that Gruden could be aiming for the Louisville job. ... So when — if? — the Redskins score a TD Monday night against the Eagles, will their new play-caller, Sherman Lewis, shout, “BINGO!”? For those unaware, Lewis, out of the league since 2004, was calling numbers for everyone’s favorite leisurely pastime at a senior citizens center two weeks ago when Washington came looking for him.

Eager to see if ex-Monmouth University WR Miles Austin can keep up the good work for the Cowboys now that’s he’s starting Sunday against the Falcons, just reward for his career day (10 catches, 250 yards, two TDs) in the OT victory over the Chiefs two weeks ago. The man dropped to No. 3 wideout, mouthy Patrick Crayton, is a riot, upset he wasn’t told by coach Wade Phillips or offensive coordinator Jason Garrett prior to Wednesday’s practice he’d been demoted. “I would have loved it,” Crayton said. “It would have been real stand-up. That’s not what happened. Oh, well.” Phillips thought Crayton had been informed but doesn’t see the big deal, anyway, saying, “I mean, it’s obvious.” To everyone except Crayton, it seems. ... Best place to be today: Heinz Field for Vikings (6-0) at Steelers (4-2). The Favres survive this trip to the Roethlisbergers and their quest for perfection picks up steam.

How much more are passing games dominating this season? Gotta hand it to my pals at the Elias Sports Bureau for having these numbers at their fingertips: QBs who have thrown for more than 300 yards in a game this season are 29-10, a winning percentage of .743. That’s the highest it has been in that category since the league adapted its 16-game schedule in 1978. ... Want more evidence of pass overriding run of late? Over the past two seasons, 300-yard passers are 47-28-1 (.665). From 1978-2007, our 300 yarders were winning at only a .504 clip and came in at less than .550 in 25 of 30 seasons.

Bengals RB Cedric Benson, third in the league with 531 rushing yards, would love to dole out a heaping helping of “Told ya so” to Da visiting Bears today. Benson was picked fourth overall by Chicago in 2005 but was considered a bust there. Now he’s been reborn, while the guy who replaced him, Matt Forte, is struggling. Funny business. ... Most anticipated debut of the day is in Houston, were 49ers rookie WR Michael Crabtree starts after finally ending his holdout. Don’t expect him to keep pace with Texans WR Andre Johnson just yet. ... Now that Raiders coach Tom Cable has been cleared of criminal charges that he assaulted former assistant coach Randy Hanson, he can go back to concentrating on the business at hand — beating the Jets Sunday and waiting to be fired by Al Davis before 2010.

THE LIST: No impact from Vick
If Eagles coach Andy Reid has grand plans to have backup Wildcat QB Michael Vick play more, he has kept them under wraps in the southpaw’s first three games, when he had only 11 touches. Hard finding many snaps for Vick behind Donovan McNabb or Kevin Kolb thus far. In fact, Vick has been on the field fewer times with the first team each game (11, five, two).

Opp  Comp  Att  Pct  Yards  TDs  INTs  Rush Yds  Atts  Avg.  TDs  Result

Chiefs    0      2   .000      0      0      0            7          1     7.0     0     W, 34-14
Bucs     1      3    .333    14      0      0          10          4     2.5     0     W, 33-14
Raiders 0       0    .000     0      0      0           -4          1      -       0      L, 9-13
Totals   1       5    .200    14      0      0          13          6     2.2    0      2-1


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Robles family of Rahway to take part in Arc Walk/Run fundraiser

Suburban News By Suburban News Suburban News
on August 06, 2013 at 5:40 PM, updated August 06, 2013 at 5:43 PM
Pix-0814RoblesFamilyArc.jpgTerrence Robles

The Robles family is stepping up. In fact, the Rahway family is the first team to register for The Arc of Union County’s 8th Annual Step Up for The Arc Walk/Run. This major fundraising event will be held on Saturday, Sept. 14 in Oak Ridge Park, Clark, and is a fun, healthy, easy way to support programs and services for children and adults with intellectual and developmental disabilities.

This is the second year that the Robles family – parents Shawn and Jessica, son Terrence and daughter Marlena – have participated in the event. Shawn and Jessica say that Terrence is precisely what motivates the family’s involvement in this event.

Terrence was diagnosed with cerebral palsy, epilepsy, and chronic lung disease, and has received services from The Arc of Union County since he was an infant. Jessica commented, “The Arc gives my son and our family a chance to get the help and support we need, so that Terrence can live his life to the fullest.” Terrence, who will be 5-years-old in November, currently attends The Arc Kohler School in Mountainside where he is given the opportunities to help him excel academically as well as socially.

Jessica stated, “I consider Terrence differently-abled, not disabled, and he lives an active life with many interests.” Terrence loves going to the movies, watching cartoons and enjoys spending time with his mom while she jogs. His passion is fire trucks. When a local fire truck visited Kohler School not only did Terrence get to sit in it, the fire department even made him a junior fire chief.

Not only is the Robles family the first team to sign up for Step Up for The Arc, they have already exceeded their original goal of $500. In fact, they have set a new goal of $750 - $1,000. Jessica is confident they will succeed in meeting this new goal. She hopes to inspire parents of differently-abled children to expose their children to new and unique experiences, so that they too may live rich and fulfilling lives.

To make a donation to the Robles fundraising team, visit:

For more information on Step Up for The Arc and The Arc of Union County, visit:


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Union County College offering course on enhancing interviewing techinques

Suburban News By Suburban News Suburban News
on January 22, 2014 at 4:02 PM, updated January 22, 2014 at 4:05 PM

As statistics are showing signs of economic growth for 2014, employers are looking for just the right candidate to fill open positions at their firms and organizations. The new year promises some enhanced employment opportunities, and Union County College will help applicants to rise to the occasion by offering a seminar on job interview techniques during convenient Saturday hours.

While you may have the qualifications for a position for which you are applying, it is imperative that you distinguish yourself from other, similarly qualified candidates. This general session is recommended for those who are seeking a career change or promotion within an existing field, as well as recent graduates and the unemployed. The class is presented in a participatory manner with ample opportunity to address individual concerns.

“Developing Confidence for the Job Interview” will provide attendees with solid information on how to prepare for an employment interview, thus gaining confidence in their ability to “ace” the interview and land a position.

Participants will be presented with various types of trick questions that are often asked at interviews, questions that the applicant also should ask, negotiating for the salary, multiple interviews, internal interviews, body language, and closing the interview to their advantage. Participants will have the opportunity to practice and refine their responses to such questions through role playing in responding to potential interview questions.

This course will be presented from 10 a.m. to noon, on Saturday, Jan. 25.

This course is offered at that the College’s Cranford campus, located at 1033 Springfield Ave. For registration and further information, call the College’s Office of Continuing Education at 908-709-7600 or visit


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Editorial: College of New Jersey continues to grow with Campus Town project

Times of Trenton Editorial Board By Times of Trenton Editorial Board The Times, Trenton
on July 25, 2012 at 7:00 AM

With completion of an impressive building to house its School of Education, The College of New Jersey is on its way toward an expanded and updated campus to meet the needs of students well into the 21st century.

Workers are applying the finishing touches to the 72,000-square-foot building to ready the 20 classrooms, a 165-seat tiered auditorium, a multipurpose room and a first-floor cafe for the fall semester.

Meanwhile, TCNJ continues work on the ambitious Campus Town plans that will bring an array of shops and student housing on a 12-acre site across from the junction of Pennington Road and Main Boulevard.

The Campus Town vision includes a bookstore, a fitness center and a pub or micro-brewery, as well as housing for more than 400 students. The mix of shops and restaurants, planned to appeal to the community as well as students, is expected to be finished by spring of 2014.

The progression of those plans and the completion of the education building – as well a new Art and Interactive Multimedia building in 2010 — attest to TCNJ’s careful fiscal management, which has meant expansion at a time when many colleges and universities are scaling back or abandoning such initiatives.

Most of the building construction has been funded through bonds that were taken out years ago, according to college officials. That’s allowed the projects to move forward without passing those costs on the students.

And that, in turn, has contributed to TCNJ’s inclusion on the list of Kiplinger’s Personal Finance magazine’s “Best Values in Public Colleges.” This year, TCNJ placed 26th nationwide among U.S. institutions that “deliver a stellar education at an affordable price.” It was one of just three N.J. colleges on the top 100 list, earning the highest ranking among them.

Meanwhile, financing for the Campus Town project will spring from a public-private partnership made possible by a 2009 law that lets colleges and universities to bypass public bidding laws and make deals with private companies to build and operate campus facilities.

Campus Town construction is expected to create hundreds of jobs, and the project eventually will support more than 100 part- and full-time employees. It will also contribute to Ewing’s tax base and add to the economic vitality of the region.

The continuing campus improvements demonstrate TCNJ’s commitment to its students and consideration of the community.

More Times of Trenton editorials


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March 13, 2013

'Sherlock' series four confirmed by Benedict Cumberbatch

Series three is about to begin filming, but the stars are already signed up for a fourth series too

'Sherlock' series four confirmed by Benedict Cumberbatch

Benedict Cumberbatch has confirmed that Sherlock will definitely be returning for a fourth series once its next run of episodes comes to an end.

Cumberbatch and co-star Martin Freeman are due to begin filming series three of the hit detective series created by Steven Moffat and Mark Gatiss next Monday (March 18). Three new 90-minute episodes are expected to air on BBC1 later this year.

However, Cumberbatch has let slip that the actors are actually signed up for another three episodes after that. Speaking to the Radio Times at yesterday's South Bank Show Awards, he said: "We've agreed to two more series but I could get into trouble for saying that. All I know at the moment is I'm doing these three [episodes of the upcoming series] and another three."

Asked whether Sherlock could continue beyond series four, Cumberbatch replied: "It just depends on Martin and I's availability, how long we can keep it going. It depends on Steven's ability. I'd love to keep it going."

The first series of Sherlock aired in summer 2010, with a second run following in early 2012. Since then, the show's stars have become increasingly in demand. Freeman stars as Bilbo Baggins in Peter Jackson's The Hobbit trilogy, while Cumberbatch has roles in several upcoming films, including Star Trek Into Darkness and August: Osage County starring Meryl Streep.

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Nobel Prizes and Laureates

The Nobel Prize in Physiology or Medicine 1975
David Baltimore, Renato Dulbecco, Howard M. Temin

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Nobel Lecture

Nobel Lecture, December 12, 1975

From the Molecular Biology of Oncogenic DNA Viruses to Cancer

Oncogenic viruses, able to elicit tumour formation in animals, have been on the scientific scene for many years. After the early discovery of Ellerman and Bang at the beginning of this century, Peyton Rous opened up the field in its second decade and in prophetic words gave a good hint of things to come. However, these discoveries were soon forgotten and only after a long eclipse was interest in oncogenic viruses revived in the fifties. My involvement in this field began at that time when Rubin and Temin worked in my laboratory with the Rous Sarcoma Virus. When in 1958 polyoma virus, a new oncogenic virus with different properties, was isolated, I jumped at the new opportunity and started working with it. Within a short time polyoma virus became the main interest of my laboratory, to be joined, a few years later by SV40, another papovavirus. It became clear fairly soon that the molecular biology of these viruses could be worked out, and I set out to find the molecular basis of cancer induction. The results that I and a number of brilliant young collaborators have obtained during the following fifteen years have brought us close to that goal. I will review the most interesting steps of our work and will then ask some questions concerning the nature of cancer and about perspectives for prevention and treatment. I stress the relevance of my work for cancer research because I believe that science must be useful to man.

Integration: The provirus
Let me start with a brief review of our work in the molecular events in transformation. The first results, crucial for future developments, showed that polyoma virus could be assayed in certain cell cultures (1), which we call permissive, and could induce a cancer-like state in other cultures (2, 3) in which the virus does not grow, which we call non-permissive. The induction of the cancer-like state in vitro was called transformation. We were able to show that the virus contains DNA (4), and within a few years we gave the first evidence of its cyclic, or circular, shape (5), which is important for two critical biological events: DNA replication and integration. In integration, which we discovered a few years later with SV40 (6), the viral DNA becomes a provirus, i.e. it establishes permanent, covalent bonds with the cellular DNA. The cyclic configuration explains how a complete molecule of the SV40 DNA can be integrated without losses.

Integration is one of the key events in virus induced cell transformation. It explained the persistence of the transformed state in the cell clone deriving from a transformed cell, since the provirus replicates with the cellular DNA. It also permitted us to resolve one of the main questions about the role of viruses in transformation. It was known at the time that papova viruses leave their footprints in the cells of the cancers they induce and those they transform in vitro, in the form of characteristic antigens. However, it was not known whether the antigens were expressed by viral genes or by derepressed cellular genes. Hence, it was uncertain whether cells were transformed by the expression of viral genes persisting in the cells or alternatively if the virus altered the cells by a hit-and-run mechanism, changing the expression of cellular genes and then leaving. The demonstration that viral DNA is integrated in the cells in conjunction with the finding that the provirus is transcribed into messenger RNA (7) hundreds of generations after the establishment of a transformed clone, made the hit-and-run hypothesis unlikely and supported a continuing role of viral gene functions in determining transformation. This possibility was later supported by observations with abortively transformed cells, which behave as transformed only for several generations after infection, but then return to normality (8). When they are back to normal these cells no longer contain the viral DNA (9).

The viral genes that remain unexpressed in the transformed cells, such as those for capsid protein in SV40-transformed cells, were also interesting, although in a different way. In fact their expression could be renewed in hetero-karyons formed by fusing transformed cells with permissive cells (10, 11), a result that gave the first evidence that the viral functions are under the control of cellular functions. The provirus thus became a tool for studying regulation of DNA transcription in animal cells. Subsequently, the presence of giant RNAs containing viral sequences in the nucleus of transformed or lytically infected cells (12) raised the question of the initiation and termination signals for transcription in animal cells, as well as the question of processing of nuclear RNA precursors of messenger RNA, questions that are still largely unresolved.

Viral functions in transformation
Efforts were in the meantime directed at identifying the viral genes transcribed in the transformed cells. It was established that in lytic infection with SV40 the whole viral DNA is transcribed in two nearly equal parts, one early, before the inception of replication of the viral DNA, the other late after DNA replication has begun and that the early RNA is also present in transformed cells (7). Subsequently, the early and the late messengers were found to be transcribed from different DNA strands (13), an observation that facilitated the further characterization of the viral transcripts. Later work in other laboratories using specific fragments produced by restriction endonucleases confirmed and refined these findings; and the results were extended to adenoviruses by showing that a segment of the early part of that DNA is always present and transcribed in transformed cells (14, 15).

These facts suggested that some early viral function is essential for maintaining the transformed state but they could also be interpreted differently: for instance, transformation might be caused by the mere presence of the viral DNA in the cellular DNA, the persistent viral functions being perhaps required for establishing and maintaining integration.

Attempts were made to solve the dilemma by isolating temperature sensitive mutants affecting either initiation or maintenance of transformation. Many transformation mutants were found, all clustered in a segment of the early region of the viral DNA, designated as the A gene, but they were all initiation mutants (16, 17, 18). These mutations prevent the onset of transformation at high but not at low temperature, and cells transformed at low temperature remain transformed at high temperature. It was not possible to find clear cut maintenance mutants, i.e. mutations capable of causing a complete reversion of the phenotype when cells transformed at low temperature were shifted to high temperature: however, careful observation later showed that the initiation mutants are also partial maintenance mutants, since the cells they transform undergo a partial reversion of the phenotype at high temperature (19, 20, 21). This result shows that the viral genes play a continuing role in transformation; however, the failure to obtain complete maintenance mutants suggests that the relation between viral gene expression and cell phenotype is complex.

Search for the viral transforming protein
Further progress in this subject has been achieved by studying the proteins specified by the early region of the viral DNA. This work has centred around the so-called T antigen (22) present in the nucleus of cells infected or transformed by SV40 and whose synthesis and properties are affected by mutations of the A gene (23, 24, 25). In non-permissive transformed cells the antigen is a protein of molecular weight of about 94,000 daltons (26), which binds firmly to double-stranded DNA, but without much specificity (27, 28, 29). That the T antigen is specified by the viral DNA is strongly suggested by its in vitro synthesis using a wheat germ extract primed with various messengers (30), especially since the size of the product depends on the nature of the messenger. Thus, when the messenger was viral RNA made in vitro by transcribing SV40 DNA with E. coli RNA polymerase, an antigenic protein of about 62,000 daltons was synthesized; but when mRNA extracted from infected cells was used the protein synthesized was, like the T antigen of transformed cells, of about 94,000 daltons. The discrepancy of the two molecular weights makes it very unlikely that the T antigen is a cellular protein modified by a viral function, because two different proteins would have to be modified in the same extract depending on the messenger used. In contrast, the synthesis of a shorter polypeptide chain with the artificial messenger may be justified by the absence of accessory signals, such as cap, poly A, and possibly other modifications. Further definition of these findings awaits peptide maps of the various products.

Since the early, transforming part of the SV40 genome can specify proteins of a molecular weight of about 100,000 daltons altogether, the T antigen is likely to be its sole product and, therefore, to be the transforming protein. However, the same protein must also initiate viral DNA replication, which cannot initiate at high temperature in cells infected by mutants of the A gene. The different functions in transformation and lytic infections could be performed by different domains of the same protein, or could result from modifications (such as phosphorylation and glycosylation) or from processing. Processing of SV40 T antigen seems to occur in lytically infected cells which contain a smaller T antigen of about 84,000 daltons; this smaller size contrasts with the regular size (94,000 daltons) of the antigen specified in vitro by mRNA extracted from the same cells (26). Whether the two forms of the antigen have different roles in transformation and DNA replication still remains to be established.

Since the transforming protein should control both initiation and maintenance of transformation the partial reversion of the phenotype of cells transformed by A mutants when shifted to high temperature may be explained by a decreased requirement for the transforming protein once transformation has taken place, which in turn could result from a positive feedback stabilizing the transformed state. For instance, unstable protein monomers specified by the mutated gene might form self-stabilizing oligomers (31), or the transforming protein might generate changes that tend to favour the transformed state. An example of the latter model is the beta galactosidase induction in E. coli which is maintained by inducer concentrations much smaller than that required for initiating induction, because inducer is pumped into the cells by the induced permease (32). I wonder whether a certain degree of self-stabilization of the state of gene expression is a general property of animal cells, which has developed for maintaining differentiation.

Cellular events in transformation
I now wish to turn to cellular events participating in transformation, which will be the main problem after the remaining questions on the role of the virus have been answered. Among the cellular events are functional changes and mutations. Some functional changes, which affect many cellular properties, are associated with the shift of resting cells to growing state after infection with polyoma virus or SV40 (33, 34); other changes observed in transformed and in cancer cells in general consist of the re-expression of cellular genes normally expressed in a preceding state of differentiation, in foetal life (35). These functional changes might be caused by the binding of transforming proteins to DNA; if so they may be mediated by an alteration of transcription of the cellular DNA. However, we do not know whether the transcription pattern changes because experiments based on competition hybridization have given ambiguous results. Perhaps the methodology is not good enough. Cloning of cellular DNA fragments in phages or plasmids may afford the necessary probes for carrying out significant experiments.

In order to understand further how the virus deregulates cellular growth we would need a detailed knowledge of the mechanisms of growth regulation in animal cells, which is now lacking. However, certain useful ideas about growth regulation are now available and can be used to draw inferences on the action of the virus. Thus, it seems clear that with a given cell type growth regulation involves a complex chain of events, beginning with extracellular regulators of many kinds, probably interacting with the cell plasma membrane. Cytoplasmic mediators then appear to transmit regulatory signals from the plasma membrane to the nucleus, where they perhaps control DNA-binding proteins similar to the transforming protein of papova viruses. The complexity of growth regulation increases markedly when different cell types are considered, since they seem to recognize different sets of extracellular regulators and may have different mediators and DNA binding proteins.

Proceeding from this general picture it would be tempting to propose that the viral transforming protein replaces one of the normal nuclear regulatory proteins of the cell, and being unaffected by the mediators that control the normal protein, keeps growth related transcription going, bypassing the signals of the plasma membrane. If so, however, the transformed state should be dominant over the normal state in cell hybrids, whereas the contrary is usually true (36). On the other hand, the dominance of the normal state could be explained if the transformed cells had a changed surface, unable to respond to regulatory signals. Such a change could result from the re-expression of foetal functions to make the transformed cells anachronistic, i. e. belonging to a stage of differentiation inappropriate to that of the organism which contains them. The cells with an anachronistic surface being insensitive to the growth regulators present in the adult organisms, which operate on adult cells, would grow without control. A striking support of the role of cell anachronism in cancer has been obtained with teratoma, a tumour originating when cells from an early embryo are transplanted to an adult environment. When, after many transplants cells of this tumour are introduced back into a blastocyst, i.e. an early embryo, they return to normality (37, 38), presumably because the internal growth control of the cells becomes again matched by the environmental regulators of the recipient embryo. In this model a hybrid cell formed by fusing a transformed and a normal cell may be untransformed, if the normal partner contributes normal surface components which respond to the normal extracellular regulators. For this result to be possible, anachronistic transcription should not be initiated after cell fusion on the DNA deriving from the normal parent. The virological studies suggest that this may well be the case, since the initiation of transformation seems to require much more transforming protein than its maintenance.

It would be important to recognize the developmental period during which the anachronistic genes of transformed or cancer cells are normally expressed, not only for understanding but possibly also for controlling cancer. In fact, if the growth regulators specific for the periods expressed in cancer cells could be identified they could be used for halting the growth of the cancer cells.

Role of cellular mutations
I will now consider the other cellular events important in viral transformation, i. e. cellular mutations. Several results suggest that cellular mutations may be needed for obtaining the full state of transformation with papova viruses. Thus, after infection primary cultures generate clones with various degree of transformation, some of which appear to undergo full transformation in steps (39) which may correspond to the occurrence of cellular mutations. Cells that achieve full transformation immediately, as are common with permanent lines, may have already undergone similar mutations before infection. Some cellular mutations occurring in transformed cells may even be virus-induced, because in the early stages of transformation by papova viruses cells of primary cultures have frequent chromatid breaks (39). Conversely, cells fully transformed by SV40 can revert to a relatively normal phenotype although they still contain normal viral DNA and T antigen (40, 41). It is conceivable that these mutations are reversions of mutations of the former kind, which enhance the transformed state of the cells. Stepwise transformation may not only occur with viruses. Thus, I have observed it in primary cultures exposed to a chemical carcinogen. In this experiment fully transformed cells evolved from the normal cells, which have limited life, generating first cells with unlimited life but unable to form colonies in agar, then cells with progressively increasing colony forming efficiency in agar, to finally reach 100% efficiency.

All these observations show the important role of cellular mutations in cell transformation induced by different agents. This conclusion is reinforced and generalised by additional findings, such as 1) the experimental enhancement of the transforming activity of viruses by mutagenic agents (42), (2 by the elevated cancer frequency in some genetic diseases, and 3) by the evidence that most carcinogens are promutagens, i.e. generate mutagenic substances when acted upon by normal metabolism (43). Most of the carcinogens themselves must be activated by metabolism in a similar way in order to induce cancer.

Prospects for cancer prevention
I will now turn to some general deductions concerning the etiology and possible prevention of human cancer, which derive from the various points I have discussed so far. One deduction, deriving from the persistence of the viral DNA in the cells is that we can test whether a given DNA virus is a possible agent of human cancer by looking for its DNA in the cancer cells. I think that much more extensive surveys than those carried out so far are warranted, but they should have a sensitivity sufficient to detect fragments of viral DNA of about one million daltons, which is within the reach of modern technology, even with the most difficult viruses. A positive finding would be significant because DNA viruses do not appear to exist in widespread endogenous forms.

Another deduction is that somatic mutations are one of the fundamental ingredients of cancer although they appear to require the occurrence of several other events not yet understood. The role of mutations in turn suggest that the incidence of cancer in man could be reduced by identifying as many promutagens as possible, and by eliminating them from the environment. One important feature of this approach to cancer prevention is that it can be started now, since these substances can be identified with simple bacterial tests suitable for mass screening (44). The feasibility of prevention is shown by the fact that the promutagens already identified in a preliminary screening, such as tobacco or some hair dyes, are inessential for human life (45, 46).

However, it is practically difficult to achieve a substantial reduction of the use of these substances, as shown by the example of tobacco. According to epidemiological evidence tobacco smoke is the agent of lung cancer in man, which in Britain is responsible for one in eight of all male deaths (47). Yet only mild sanctions have been imposed on tobacco products, such as a vague health warning on cigarette packets, which sounds rather like an official endorsement. Any limitation on the use of tobacco is left to the individual, although it is clear that the individual cannot easily exercise voluntary restraint in the face of very effective advertisements, especially as he does not usually appreciate the danger of a cumulative action over a long period of time.

The lax attitude of governments towards tobacco probably also derives from the difficulty of appreciating epidemiological evidence, especially since this evidence is contradicted from time to time by single-minded individuals who use incomplete or even erroneous analyses of the data, and whose views are magnified out of all proportion by the media. However, the recent recognition that tobacco smoke contains promutagens contributes direct experimental evidence on the dangers of tobacco smoke, on which there cannot be any equivocation. I, therefore, call on governments to act towards severely discouraging tobacco consumption; and to act now because it will be at least thirty years before their action has its full effect.

Although tobacco smoke is a striking example of an environmental carcinogen, many others are known and probably many more remain to be identified. Identification by conventional tests is difficult because they are costly and laborious; but they can now be replaced by the bacterial tests for promutagens. Since the tests are easy and inexpensive it should be possible to investigate many normal constituents of the environment, and every new compound before it is offered to the public. The feasibility of such a programme is borne out by the finding that most of the commonly available substances are not promutagens (45, 46). Given the strong correlation between mutagenicity and carcinogenicity (43), any promutagen is suspect and, if all possible, should be withdrawn.

In fact, this is precisely the attitude that scientists have taken for them-selves concerning the experiments in genetic engineering, which carry the theoretical possibility of creating new virus-like molecules, endowed with carcinogenic activity. Although the danger is only hypothetical, experiments which might be very useful for science and society have been postponed until they can be carried out under the strictest safeguards (48). Governments have accepted this position and are eager to impose severe restrictions on the performance of these experiments. While I fully approve of their concern, I cannot help noticing that they follow a double standard; if there is any doubt - you must discourage experiments, but if there is any doubt - you cannot discourage cigarettes.

Biologists and society
This discussion about cancer prevention is a development of the experimental results obtained in the field of oncogenic viruses, but it is also strongly influenced by the new social conscience of many scientists. Historically, science and society have gone separate ways, although society has provided the funds for science to grow and in return science has given society all the material things it enjoys. In recent years, however, the separation between science and society has become excessive, and the consequences are felt especially by biologists. Thus, while we spend our life asking questions about the nature of cancer and ways to prevent or cure it, society merrily produces oncogenic substances and permeates the environment with them. Society does not seem prepared to accept the sacrifices required for an effective prevention of cancer. The situation is clearly unacceptable, and we biologists would like to see it corrected. We have ourselves begun to put our house in order, by banning some experiments that may contain a risk for mankind. We would like to see society take a similar attitude, abandoning selfish practices that are dangerous for society itself. We would also like to see a new co-operation of science and society for the benefit of all mankind and hope that the dominant forces in society will recognize that this is a necessity.

1. Dulbecco, R., and Freeman, G., Virology, 8, 396 (1959).

2. Vogt, M., and Dulbecco, R., Proc. Nut. Acad. Sci. USA., 46, 365 (1960).

3. Dulbecco, R., and Vogt, M., Proc. Nut. Acad. Sci. USA., 46, 1617 (1960).

4. Smith, J. D., Freeman, G., Vogt, M., and Dulbecco, R., Virology, 12, 185 (1960).

5. Dulbecco, R., and Vogt, M., Proc. Nat. Acad. Sci. USA., 50, 236, (1963)

6. Sambrook, J., Westphal, H., Srinivasan, P. R., and Dulbecco, R., Proc. Nat. Acad. Sci. USA., 60, 1288 (1968).

7. Oda, K., and Dulbecco, R., Proc. Nat. Acad. Sci. USA., 60, 525 (1968).

8. Stoker, M., Nature (London), 218, 234 (1968).

9. Berg, P., and Stoker, M., Personal communication.

10. Koprowski, H., Jensen, F. C., and Steplewski, Z., Proc. Nat. Acad. Sci. USA., 58, 127 (1967).

11. Watkins, J. F., and Dulbecco, R., Proc. Nat Acad. Sci. USA., 58, 1396 (1967).

12. Tonegawa, S., Walter, G., Bernardini, A., and Dulbecco, R., Cold Spring Harbor Symp. Quant. Biol., 35, 823 (1970).

13. Lindstrom, D. M., and Dulbecco, R., Proc. Nut. Acad. Sci. USA., 69, 1517, (1969).

14. Sharp. P. A., Petterson, U., and Sambrook, J., J. Mol. Biol., 86, 709 (1974).

15. Sharp, P. A., Gallimore, P. H., and Flint, S. J., Cold Spring Harbor Symp. Quant. Biol., 39, 457 (1974).

16. Fried, M., Proc. Nat. Acad. Sci. USA., 53, 486 (1965).

17. Eckhart, W., Virology, 38, 120 (1969).

18. Tegtmeyer, P., and Ozer, H. L., J. Virol., 8, 516 (1971).

19. Martin, R. G., Chou, J. Y., Avila, J., and Saral, R., Cold Spring Harbor Symp. Quant. Biol., 39, 17 (1974)..240 Physiology or Medicine 1975

20. Butel, J. S., Brugge, J. S., and Noonan, C. A., Cold Spring Harbor Symp. Quant. Biol., 39, 25 (1974).

21. Kimura, G., and Itagaki, A., Proc. Nat. Acad. Sci. USA., 72,673 (1974).

22. Black. P. H., Rowe, P. W., Turner, H. C., and Hubner, R. J., Proc. Nat. Acad. Sci. USA., 50, 1148 (1963).

23. Tegtmeyer, P., Cold Spring Harbor Symp. Quant. Biol., 39, 9 (1974).

24. Oxman, M., Takemoto, K. K., and Eckhart, W., Virology, 49, 675 (1972).

25. Paulin, D., and Cuzin, F., J. Virol., 25, 393 (1975).

26. Carroll, R. B., Personal communication.

27. Carroll, R. B., Hager, L., and Dulbecco, R., Proc. Nat. Acad. Sci. USA., 71, 3754 (1974).

28. Jessel, D., Hudson, J., Landau, T., Tenen, D., and Livingston, D. M., Proc. Nat. Acad. Sci. USA., 72, 1960 (1975).

29. Reed, S. I., Ferguson, J., Davis, R. W., Stark, G. R., Proc. Nat. Acad. Sci. USA., 72, 1605 (1975)

30. Smith, A. E., Bayley, S. T., Wheeler, T., and Mangel, W. F., In "In vivo Transcription and Translation of Viral Genomes"., Eds., Haenni, A., and Beaud, J., INSERM, Paris, 47, 331 (1975).

31. Dulbecco, R., Proc. Royal Society, Lond. B., 189, l-14 (1975).

32. Novick, A., and Weiner, M., Proc. Nat. Acad. Sci. USA., 43, 553 (1957).

33. Dulbecco, R., Hartwell, L. H., and Vogt, M., Proc. Nat. Acad. Sci. USA., 53, 403 (1965).

34. Hartwell, L. H., Vogt, M., and Dulbecco, R., Virology, 27, 262 (1965).

35. Coggin, J. H., J. Immunol., 105, 524 (1970).

36. Wiener, F., Klein, G., and Harris, H., J. Cell Sci, 8, 681 (1971).

37. Mintz, B., and Illmensee, K., Proc. Nat. Acad. Sci. USA., 72, 3585 (1975).

38. Papaionnou, V. E., McBurney, M. W., Gardner, R. L., and Evans, M. J., Nature (Lond.), 258, 70 (1975).

39. Vogt, M., and Dulbecco, R., Cold Spring Harbor Symp. Quant. Biol., 27, 367 (1962).

40. Pollack, R. E., Green, H., and Todaro, G. J., Proc. Nat. Acad. Sci. USA., 60, 126 (1968).

41. Renger, H. C., and Basilica, C., Proc. Nat. Acad. Sci. USA., 69, 109 (1972).

42. Stich, H. F., San, R. H. C., and Kawazoe, Y., Nature (Lond)., 229, 416, (1971).

43. McCann, J., Choi, E., Yamasaki, E., and Ames, B. N., Proc. Nat. Acad. Sci. USA., In press.

44. Ames, B. N., Lee, F. D., and Durston, W. E., Proc. Nat. Acad, Sci. USA., 70, 782 (1973).

45. Kier, L. D., Yamasaki, E., and Ames, B. N., Proc. Nat. Acad. Sci. USA., 71, 4159 (1974).

46. Ames, B. N., Kammen, H. O., and Yamasaki, E., Proc. Nat. Acad. Sci. USA., 72, 2423 (1975).

47. Doll, R., J. Roy Stat. Soc., Series A, 134, 133 (1971)

48. Berg, P., Baltimore, D., Brenner, S., Roblin, R. O., and Singer, M. F., Proc. Nat. Acad. Sci. USA., 72, 1981 (1975).

From Nobel Lectures, Physiology or Medicine 1971-1980, Editor Jan Lindsten, World Scientific Publishing Co., Singapore, 1992

Copyright © The Nobel Foundation 1975
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You can add several mailboxes and access them directly from your home screen. In the main mail view, you can switch from one mailbox to another.

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We’re available seven days a week, including evenings and most holidays. Our facilities are warm and inviting, and all of our doctors are board certified in internal medicine, family practice or emergency medicine. We do not have any physician assistants or nurse practitioners on staff, which means you will be seen by a doctor and receive the highest level of care in a timely manner. Our goal is to provide you the medical assistance you need, when you need it, so you are on your way to recovery as soon as possible.

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1.5 Changing the Timeout Value for ZENworks Control Center

By default, ZENworks Control Center has a 30-minute timeout value, so if you leave ZENworks Control Center idle on your computer for more than 30 minutes, you are prompted to log in again to continue.

The purpose of the timeout is to clear memory resources. The larger the timeout value, the longer ZENworks Control Center retains the memory resources, which might have a negative impact on the long-term performance of the device from which you have launched ZENworks Control Center, including the ZENworks Server if you have it running locally on it.

To increase or decrease the timeout value, you modify two XML files on the ZENworks Server. The change applies only to that server’s ZENworks Control Center. Therefore, any devices that launch ZENworks Control Center from that server experience the same timeout value.

You can make the ZENworks Control Center timeout value different on each ZENworks Server in the Management Zone.

To change the ZENworks Control Center timeout value on a ZENworks Server:

  1. Open the custom-config.xml file in a text editor.

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    The custom-config.xml file is located in the same directory as the config.xml file:

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  2. Locate the <setting id="timeout"> entry.

  3. Set the timeout value to the same number as you entered in the config.xml file.

  4. Remove the comments surrounding the <setting id="timeout"> entry (<!-- and -->).

  5. Save the custom-config.xml file.

  6. Restart the ZENworks Server service.

    For instructions, see Section 9.0, ZENworks Server.


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Property Name Plaza House Apartments
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The Plaza House Apartments in Kansas City, Jackson County, Missouri is eligible for inclusion on the National Register under Criterion C for local significance in the area of ARCHITECTURE. It meets the registration requirements defined by the MPDF Working-Class and Middle-Income Apartment Buildings in Kansas City, Missouri for the High Rise Apartment Building sub-type . Designed by the prominent local architectural firm of Voskamp and Slezak, it is an early and definitive example of a high-rise apartment building in the Modern Movement style. Constructed in 1955, the period of significance, the eleven-story building contains seventy-two apartments arranged around aT-shaped, double loaded corridor. Defined by its distinct rejection of historic elements, geometric massing, and juxtaposed horizontal and vertical emphasis, the building precisely represents the Modern Movement and retains excellent integrity of character defining features, both on the interior and the exterior. Furthermore, the Plaza House Apartments stands as a testament to the progress and expansion of Kansas City and the impact of highrise apartment buildings on local settlement patterns.

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The package delivered was deeply alarming. In addition to correspondence, there was a draft of legislation prepared by industry lawyers—Washington insiders—that would have banned many models of handguns. It was very well crafted.

McClure saw it as a blatant restraint of trade. It cut out many innovative small companies by specifically requiring patented safety features that existed only on handgun models produced by a handful of companies.

McClure was as angry as his staff had ever seen him. He drafted a letter to the CEOs of those companies. Each paragraph began, “Tell me it ain’t so.”

Allowing time for his message to sink in, McClure called a meeting with the companies’ CEOs, who were ushered into the senator’s office.

McClure’s intent was to lay out the political realities of the new Senate. With none of the usual small talk, he spoke directly and gravely. After the CPSC victory, he said, it is clear that your consumers are the real power. Trust them. Everything has changed, and there is neither reason nor room for any compromise.

He told them with certainty that the line would be held in the Senate; that Kennedy’s gun control forces simply did not have the votes for a gun bill. But, he warned, there was one element that could change that dynamic—an industry intervention.

Brandishing the industry letters, he said softly, “I know everything—all of it.”

As he started to explain his plans for positive action in the Senate, McClure was interrupted with:

“Senator, you don’t understand. We believe that unless we act, our enemies in Congress will put us out of business within five years.”

McClure’s response was quiet and measured.

“No. You’re the one who doesn’t understand. You do this, and I will put you out of business a lot quicker than your enemies will.”

At that point, one CEO stood, and with gravity said, “Thank you very much, senator. We get the message. We trust you.”

That was that. The meeting ended, and ultimately so did the deal with Rep. Rodino.

Without that event, there is no doubt that an industry-supported partial handgun ban might well have become reality. Perhaps the ce0s’ position was understandable. In the face of a Senate-passed ban in 1972, a compromise option might have made sense.

But not after the CPSC fight—the winds had changed.

Furthermore, because of this pivotal see-the-light moment, the industry ultimately joined its consumers in fighting the so-called Saturday Night Special issue. As a result of that united front, the handgun ban never happened.

And that meeting paved the way for today’s stronger alliance between NRA and industry which has been critical in enactment of legislation like the Protection of Lawful Commerce in Arms Act.

So, what made McClure so successful as a legislator? Experience, for one thing. He came to the Senate with three terms in the Idaho Senate, and three in the U.S. House of Representatives.

But the United States Senate was different. There was much to learn. Jim McClure possessed a remarkably quick mind for critical detail. His long hours pouring over the rules and over old debates gave him a mastery of Senate proceedings that was unparalleled.

And he spent hours presiding over the Senate, volunteering for “chair duty,” an onerously boring task assigned to freshmen who gladly deferred to McClure.

As he watched over the routine business of the Senate day in and day out, he studied something else—the players. He absorbed the political dynamics of the Senate as a body. And he had the measure of individual Senators—all of them.

When he was done, he possessed a unique ability: He could see the entire forest because he knew the trees.

At the same time, McClure, as a conservative, pointedly not as a Republican, was instrumental in organizing something called the Senate Steering Committee, an ad hoc group of like-minded Senators. This floating alliance, which often included Democrats, served the cause of the Second Amendment well.

For gun owners who were his contemporaries, his passing should be revered; for those not old enough, it should be understood and equally honored. Jim McClure was an icon.

Senator McClure is survived by his wife, Louise; daughter, Marilyn Roach; sons Ken and David; six grandchildren; and one great-grandchild.
Editor’s Note: Contributing Editor Jim Norell left McClure’s staff in the fall of 1975 to answer a call from Harlon B. Carter to join the then-new NRA Institute for Legislative Action as director of communications. Norell is an award-winning screenwriter and a freelance journalist.

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Berkeley junior Glory Liu performed the vocals in "The Nano Song."

UC Berkeley junior Glory Liu--a classics and political economy major with three years of classical music training--performed the vocals in "The Nano Song," cheerfully explaining nanotechnology to a band of puppets. Lyrics include the lines, "A million nanometers that are lined up in a row/Are just about as long as a single flake of snow ..."

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Press Release 08-066
A CluE in the Search for Data-Intensive Computing

Unique relationship between Google, IBM and NSF allows academic computing research community to access large-scale computer cluster

Back to article | Note about images

An artist's rendition of a server farm, showing rows of computers planted like crops.

In the last five years, private sector companies have launched a number of highly effective Internet-scale applications powered by massively scaled, highly distributed computing resources known as data clusters. Sometimes referred to as data centers or server farms, these clusters contain as many as 90,000 servers, each co-located with hundreds of gigabytes of data. These increases in network capacity and fundamental changes in computer architecture are encouraging software developers to take new approaches to computer-science problem solving.

Credit: Zina Deretsky, National Science Foundation

Download the high-resolution JPG version of the image. (2 MB)

Use your mouse to right-click (Mac users may need to Ctrl-click) the link above and choose the option that will save the file or target to your computer.

Jeannette Wing, assistant director for computer and information science and engineering at NSF, discusses the CluE solicitation.

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Researchers Discover Workings of Brain's "GPS System"

March 6, 2013

grid cells fire in response to mouse's location A new study from researchers at Princeton University provides evidence for how the brain determines the body's location as it moves through its surroundings. Full Story

Princeton University

The National Science Foundation (NSF) is an independent federal agency that supports fundamental research and education across all fields of science and engineering. In fiscal year (FY) 2014, its budget is $7.2 billion. NSF funds reach all 50 states through grants to nearly 2,000 colleges, universities and other institutions. Each year, NSF receives about 50,000 competitive requests for funding, and makes about 11,500 new funding awards. NSF also awards about $593 million in professional and service contracts yearly.

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What makes a data visualization memorable?

October 16, 2013

a range of visualization types "Chart junk"--the noisy visual elements that attract criticism in design circles--can help make a data visualization more memorable. And the chart types we learned about in school (bar graphs, pie charts, etc.) are not the easiest to recall. Full Story

Harvard University

The National Science Foundation (NSF) is an independent federal agency that supports fundamental research and education across all fields of science and engineering. In fiscal year (FY) 2014, its budget is $7.2 billion. NSF funds reach all 50 states through grants to nearly 2,000 colleges, universities and other institutions. Each year, NSF receives about 50,000 competitive requests for funding, and makes about 11,500 new funding awards. NSF also awards about $593 million in professional and service contracts yearly.

 Get News Updates by Email

Useful NSF Web Sites:
NSF Home Page: http://www.nsf.gov
NSF News: http://www.nsf.gov/news/
For the News Media: http://www.nsf.gov/news/newsroom.jsp
Science and Engineering Statistics: http://www.nsf.gov/statistics/
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