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Tuesday, April 30, 2013

Diagnosis Design #7 Jocelyn Olson

First an intro...

In medicine, we document using SOAP notes. It is an abbreviation to help keep consistent format when logging information.

S=Subjective. What does the patient report. Subjective Data. This also includes the Chief Complaint (CC) which tells what the patients main problem is and History of Present Illness (HPI) a history of what happened to bring them in.

O=Objective. What exam findings do you gather. Objective Data.

A=Assessment. What is your Diagnosis, what differentials could there be (alternative diagnoses)

P=Plan/Education. What is the plan for the patient. What do you want them to learn?

This is the format I will use also.

Now lets begin. This is Jocelyn Olson...

Hanging out at a park with her dad and kids.

How did I come to know Jocelyn? I was looking at the Paper Crafts Blog in April of 2012. New on the scene, I was trying to just figure things out. I didn't know who was who or what was what then. I saw the card below which was nominated for Stamping Royalty 2012 and thought, what a perfect card. How can this card be so so perfect? No smudging, straight, the color choice was a little different for a holiday card, but I think that is what made it so wonderful. I loved it!

So I did something that I had never done before. I looked at the name of the artist who made it and tried to find her. I began following her blog immediately and I was hooked. She made hand made cards look professional to me. I would study her work trying to figure out how she did it. Then I found out a magical and scary word: DIGITAL. I admire what she has brought to the crafting world, digital that is beyond just print and cut. She is the master of digital, digital-hybrid, and 100% handmade stamped cards and is bringing digital to the mainstream.

I usually chose designers whose work is very easily identifiable. For Jocelyn, it took me a little longer, but I can usually still identify her designs based on her aesthetic. I hope that after reading this, you will be able to pick out a Jocelyn card out of a line up as is the case for other DD candidates.

 (For the record, this card IS stamped, not digital) Next thing I knew, she was a fellow Paper Crafts Gallery Idol gal and I have loved her even more since!

Her creative resume is so so good. She has won numerous prestigious titles and contests, published a gazillion times and I think after you read about her work, and see what she can do, you will understand why.

Tell me about yourself, how did you and your husband meet?
My husband and I met on a blind date. My mom and his dad worked together and had adjoining
offices. They would talk about their kids and decided it would be a good idea to fix us up on a
blind date. I was living in Texas at the time, and when I went to visit my mom at Thanksgiving,
she sprung it on me that a trip to a sports bar to watch a basketball game would really be a blind
date. I was annoyed but went along with it. So my mom, brothers, and their wives were on our
first date to watch the basketball game at a local sports bar. Afterwards, I told my mom that he
was nice, but it wasn’t like anything was going to happen (“I live in Texas…he lives in South

A couple of weeks later, my (now) husband sent me a letter. It was before e-mail was as
mainstream as it is now, but it was still romantic. We wrote letters back and forth for seven
months before we saw each other again. Within a week of seeing each other again, we pretty
much knew we would get married (that was 15 years ago).

Her husband Craig and daughter Leni at a historical quilt show. The quilt behind them is one Craig's grandmother made.

CC: I want it to be perfect. and if you do, digital is the way to go!

HPI: Jocelyn has turned us regular crafters into believers of the digital possibilities. She can manipulate images like no one I have ever seen. And just for the record, talking to Jocelyn is like therapy. She is very good saying and asking just the right questions to get you to talk AND feel better.

You will find that her cards are therapeutic also. The sentiments she uses convey messages of hope and promise...

What program do you use to make your digital and hybrid cards?
Photoshop Elements 11.0. I’d love to get the full-size Photoshop program, but Elements is much
cheaper. It was the best $70 I’ve spent on crafting.

Where do you find inspiration?
My biggest sources of inspiration come from online places like Pinterest, fellow designers’
blogs, general design blogs, and Etsy. I love looking at new product lines (both digital and
traditional), and I always get ideas for cards that way.
I also find inspiration in unusual places like my three-year-old’s books. My husband and I have
collected art, mostly from when we travel, and that provides me with ideas. I have a giant oil
painting of a lawn chair in my craft space. ;) (her craft area is a small corner in the dining room).

What do you do for a living? Does it influence your design?
I’m a research and evaluation consultant for state, federal, and higher ed disability and special
education programs. I was a professor and went back and forth between teaching and research
for over a decade, but when we moved to South Dakota, I decided to take the leap and become

My work and my paper crafting are pretty separate, although I do sometimes find card sketches
in my work files. The move into the digital world was influenced by my work. I travel to other
states from time to time for work, and since I always have my computer with me, I can design
any time I travel. Last summer I participated in Gallery Idol, and for one round, I was designing
one of my cards on the flight home. A couple of months ago, we were driving home from
Minneapolis (in a snow storm, no less), and I was on Photoshop make a card for a call. You get
the idea.

Did you take a digital class when you first started?
No, I’m all self-taught.

Why did you chose digital?
The main reason I started using digital elements is because I would have an idea in my head, and
I didn’t have the products to execute it. Frankly, I was frustrated because I couldn’t find stamps
and papers in the designs I wanted. Now I can usually either find an image I want or make it

Otherwise, here are my top five reasons:
1) Convenience (like I already said)
2) The huge diversity of products
3) I can tweak images, like change the color or scale of an element, to fit the project
4) The undo button is my friend J
5) I don’t have a big craft space, and I don’t have to store as much stuff

Card you are most proud of?
I’ve always been proud of my “Hey” card. The card was published in Paper Crafts Magazine,
and although it wasn’t my first published hybrid card, it represents a turning point in my mind
for when I fully committed to hybrid designs.

(comic book inspired cards have become her signature)

What are your best publishing tips?
Before I started blogging, I stalked a lot of blogs for several months. One of my favorite bloggers
was Chan Vuong, and I contacted her for some tips for getting published. She gave me some
great pointers that I would not have known at the time (e.g., make projects other than cards,
use new products, take a close-up photo of the project, etc.). She was incredibly helpful and
supportive. I’m no publishing expert. I guess I’ve had the best luck with submitting projects with
less common products.

How long do you think about a card before you are on the computer creating it?
A long time. When I get a design team assignment or a call, I typically think about the project(s)
for about a week before I do anything. What can I say? I’m a slow crafter.
Total card time (how long it takes to create a card from start to finish?
From the point I sit down to start crafting, it usually takes me about 1-3 hours to make a project.
Cards with a digital element are usually slower for me, but that could be because I’m distracted
by e-mail, Facebook, TV, etc. Traditional (non-digital) cards are typically faster, but I obsess
over things like cardstock and ink colors.

Favorite place to buy clothes?
I’m short and need short lengths. I tend to shop at Ann Taylor Loft or Banana Republic since
they’re available locally. Since I work out of my house, I don’t buy clothes as often anymore.

Funniest joke you ever heard?
I’m a big fan of Laffy Taffy jokes—the cornier the better. I hate when I buy a Laffy Taffy and
it’s a repeat joke (which of course means I’ve eaten far too many Laffy Taffies).
Here’s a pin that always makes me laugh out loud: http://pinterest.com/pin/89016530104407243/

Most admired blogger?
Oh goodness, I’ve been dreading this question because it’s like choosing between a slice of
lemon meringue pie and a piece of chocolate cake (I must be hungry). My favorite bloggers are
ones who make projects that make me wonder “why didn’t I think of that?”

Saddest thing about blogging?
Without a doubt, the saddest thing is when a fellow paper crafter passes away.

What is the secret to longevity to bloghood?
I have no idea. I suppose I should be more analytical about it, but I just try to keep my head
down and do my own thing.

How long have you been crafty?
Like most crafters, I’ve always been crafty. I used to love to draw and make sticker books.
I loved my Fashion Plates, Lillian Vernon personalized colored pencils, and metallic paint
markers. In my 20s, I dabbled in cross stitching and quilting but was pretty terrible at both. I
didn’t get into papercrafting until I was in my 30s.

Most pinned card?
I’m not completely sure since it’s hard to tell with Pinterest, but I know I had a bunch of pins on
a card from September 2011. It’s not my favorite card, but I still get weekly traffic on my blog
for this card.

The best way you can see a persons style is through a body of work. Let me show you what Jocelyn can do. These are some of my most favorites...

There is always an element of FUN in her designs.

It's difficult to discern which cards are digital and which are not. This one? Digital Hybrid!

She understands color.

You don't have to work hard to get the message.

Do you notice:
  • Her cards look like magazine ads. They are graphic, CAS, and bold. Her use of color is very conscious and purposeful and mainly because she can create just the certain perfect color that a regular stamp pad can't always touch.
  • Her cards are not SERIOUS, there is always a touch of fun whimsy to them. Even when the card IS intended to be serious, somewhere there is still fun. See the feather below? Just a little fun for an otherwise more serious card.

  • She uses nothing typical or ordinary. The fonts are fresh because they are different and computer based fonts. The possibilities in her designs are limitless.

****For fun I asked Jocelyn to show me how she creates a digital hybrid card from START to FINISH. WATCH!!!****

Whimsical Graphic Hybrid Design

In asking the community what makes Jocelyn stand out amongst the rest and what they like about her work...

JOSCELYNE CUTCHENS (PAPERCRAFTS MAGAZINE GALLERY IDOL WINNER 2012, OWNER OF BOSSY JOSCIE FLAIR): I love Jocelyn's style, it's cute but not cutesy, modern but not stark. She's not afraid to mix things up and use a punny sentiment, I absolutely love that about her. She's a whiz at piecing together digital and traditional for some of my favorite hybrid cards around. Jocelyn is also a super sweet lady with a cool name.

HEATHER CAMPBELL (PAPER CRAFTS MAGAZINE GO TO GAL 2013, GALLERY IDOL TOP GALLERY IDOL TOP 10, STAMPING ROYALTY WINNER 2012): Jocelyn has some serious style when it comes to paper crafts. She's witty and the girl must have an amazing sense of humor because it radiates from her designs. Her knowledge of digital and hybrid cards puts her in a league of her own.

LUCY ABRAMS (DESIGNER FOR HERO ARTS, STUDIO CALICO AND SIMON SAYS STAMP): Jocelyn is a ROCKSTAR!! Jocelyn has long been a favorite designer of mine. She combines style and fun effortlessly, using products in wonderfully unique and clever ways. I mean, look how cute THIS doughnut card is. Eeek!! And creating THIS neon card with digi stamps... amazing. I always love seeing Jocelyn's cards in magazines. She truly is a talented and diverse card maker with a real eye for detail.

Think you want to join this genre?

  • Buy photoshop. One cannot do her body of work without it. It's the only way to get that crisp effect that is so typical of her work.
  • Clean it up. Jocelyn is a clean and simple gal. She flexes her design power with color and graphics
  • Don't be shy. Her designs don't hide. The sentiments and images are in your face telling you something...and you are gonna like it! So Go Big or Go Home!

 How long have you been crafting?
Almost 7.5 years ago, I walked into a Michael’s to look at cake decorations, and I saw the
scrapbooking supplies. I was pregnant at the time, and as I strolled through the aisles, I had the
brilliant idea to make 100+ handmade birth announcements. A couple of months later, as I was
trying to match the various ribbons and patterned papers in the dark with a newborn on my lap,
the idea didn’t seem so brilliant.

I dabbled in paper crafting for gifts over the next couple of years and bought a die cutter to
cut felt for crafty projects. It wasn’t until I found a fabulous nearby stamp store (The Crafting
Cottage in Corning, NY) about five years ago, though, that I really became immersed in
stamping and paper crafting.

If I had to pick a song that represented Jocelyn to ME, it would be this one:
Don't worry Be Happy by Bobby McFerrin. Her work is fun, happy, and always conveys a positive message.

Thank you Jocelyn for taking the time to answer the questions and giving me full access to your blog Red Balloon Cards.

Where did the name of your blog come from?
It’s from the book Goodnight Moon (Goodnight light, and the red balloon). My son was just a few months old when I started blogging. He was colicky and a bad sleeper, and I think that was one of the few phrases my sleep-deprived brain could come up with. The irony is, I don’t really like balloons very much IRL.

  1. Hooray for Jocelyn! Not only do I love her work, but she has a sweet personality. She was one of the first crafting friends I made. Go Jocelyn!!

  2. Mega love. Seriously. Kudos to you for being so amazing! (and it means BOTH of you!!)

  3. I LOVE Jocelyn! She really does make me want to go digital.....and she is just so nice and genuine and fun! Great write-up, love learning more about the legend! ;)

  4. I LOVE it, Wida!!! It's cracking me up reading it. Thank you so much for asking me!!

  5. What a TREAT to read about Jocelyn and creating process! Excellent interview, Wida!

  6. I totally love Jocelyn! she cracks me up on the regular. ps. i don't love real balloons much either, but i love balloon images. haha.

  7. So fun getting to Jocelyn behind the scenes...she makes some amazing cards!

  8. If nothing else I have learnt that I need to find out how to rotate brushes in Photoshop - watching that vid has made me think I've maybe been doing it cack-handed all these years!!

  9. Jocelyn has long been one of my favorite cardmakers out there! She's funny, sweet, and way smart:) Every card she makes (even the CAS ones) are full of thought and design. And what she does digitally? U-N-R-E-A-L! Thanks for bringing us more Jocelyn Wida!

  10. I love this series on your blog, Wida. Keep it up! Jocelyn is amazing. She is one of the first bloggers/card makers I was drawn to. Her designs are always spot-on and well executed!

  11. Loved getting to know more about Jocelyn! She has such a fun style and outrageous talent for hybrid cards!!!

  12. What a fabulous feature. I so enjoyed reading about Jocelyn. I love the graphical look of her designs. :)

  13. Hand clapping going on here - soooo happy you did this for Jocelyn. I love that girl's work. Her CAS mastery of digital blows my mind, but what I love most about her work is her way with sentiments. So fun to learn more about her and I think you were spot on with your diagnosis!

  14. Such a WONDERFUL post!! I love Jocelyn's work...she really is amazing and sweet! :)

  15. Long time fan of Jocelyn! Loved reading about her!

  16. I love this post! You made it so interesting! I've been following Jocelyn for a while, it's nice getting to know her better through your post. TFS.

  17. I love Jocelyn - she's my fave! I stalked her for awhile until I made her like me ;) Seriously though, I loved her work from the beginning and can spot one of her cards almost anywhere. I'm glad you did this and that I got to read it! I'm off to stalk her some more...........

  18. MOST EXCELLENT post Wida!
    I too am a fan of Jocelyn's.
    She is a MASTEr digi crafter...would LOVE to see more of her magic on video:)

  19. This is so fun! Jocelyn has definitely made me return to my digital roots and want to try making my own hybrid cards. You are Amazing Jocelyn!

  20. I loved reading this about Jocelyn! DD is one of my favorite pieces in blogland Wida....Love it!

  21. Oh I LOVED reading more about Jocelyn!! She's the best, all around!! Wida, great insight in your diagnosis ... magazine ad worthy, a little whimsy, and a fresh sentiment. So right on! I was glued to my couch the whole time!

  22. Great choice Wida! Jocelyn's cards are amazing!

  23. An awesome Diagnosis of our awesome supertalented friend. Jocelyn always makes my eyes pop with her amazing hybrid creations, and she is someone I could really learn a lot from! Was great reading more about her too and the trip down memory lane of her creations was perfect. :-)

  24. Jocelyn is amazing, thanks so much for sharing an insight into her papercraft life!

Thank you for stopping by...


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Massage Therapy Instructor

Milan Institute

High School diploma or GED required. Massage Therapy license from an accredited school with proof of national certification in therapeutic massage and body work…
From Milan Institute – Fri, 22 Jul 2022 17:22:54 GMT – View all Sparks, NV jobs

Before applying for this position you need to submit your online resume. Click the button below to continue.

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Yoga for Chronic Fatigue Syndrome: alleviate symptoms of CFS/ME

yoga for chronic fatigue syndrome

Yoga can be your ally when suffering from Chronic Fatigue Syndrome (also known as Myalgic Encephalomyelitis).

In spite of the name, CFS symptoms are not limited to extreme fatigue; patients often suffer from chronic pain and neurological symptoms. It is an illness that affects all systems in the body.

Yoga has been proven time and time again to reduce chronic pain, improve mental health, increase strength and flexibility and aid sleep. However, people with chronic conditions might be intimidated by the practice. Too often when we refer to yoga we tend to think of people standing on their head or performing contortionist postures. This is not what yoga is.

We can practice yoga in many different ways and adapt it to what our body needs on a certain day. We need to approach yoga as a mindful practice, rather than a workout.

It is important to know who you are practicing with, their knowledge and qualifications. Not all styles will benefit CFS. I personally find Gentle Hatha, Yin Yoga and Restorative Yoga to be the most beneficial. In addition, you can try to practice mindfullness and meditation on its own, as well as Yoga Nidra.

Yoga for Chronic Fatigue Syndrome: alleviate the symptoms of CFS/ME

You might also find this blog interesting.

You can find more free classes on my YouTube Channel.

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Wednesday, April 21, 2021

His To Protect - Book Tour and Giveaway

His To Protect
by Sharon C. Cooper
Genre: Romantic Suspense

She looked a criminal in the eye...
...and now she's a target.

When Connie Shaw witnesses a bank robbery gone horribly wrong, security specialist Trace Halstead makes himself her personal protection detail. Days and nights together make it impossible for Connie and Trace to resist the attraction burning between them. But Connie doesn’t know which she fears more…the threat from the man who wants to end her life or the love of the man trying to save it.

From Harlequin Romantic Suspense: Danger. Passion. Drama.

Award-winning and bestselling author, Sharon C. Cooper loves anything that involves romance with a happily-ever-after, whether in books, movies, or real life. Sharon writes contemporary romance, as well as romantic suspense and enjoys rainy days, carpet picnics, and peanut butter and jelly sandwiches. She’s been nominated for numerous awards and is the recipient of an Emma Award for Romantic Suspense of the Year 2015 (Truth or Consequences), Emma Award - Interracial Romance of the Year 2015 (All You’ll Ever Need), and BRAB (book club) Award -Breakout Author of the Year 2014. When Sharon is not writing or working, she’s hanging out with her amazing husband, doing volunteer work or reading a good book (a romance of course). To read more about Sharon and her novels, visit

Follow the tour HERE for special content and a giveaway!

$10 Amazon

1 comment:


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Children of Thomas Brooks (1775 – 1838) and Wife Sarah Whitlock: Margaret Brooks (1803-1855) and Husband Ransom Van Winkle — Wayne County, Kentucky Years

Tombstone of Margaret Brooks Van Winkle and Ransom Van Winkle, Franklin town cemetery, Franklin, Morgan County, Illinois, by Connie Clark: see Find a Grave memorial page of Margaret Brooks Van Winkle, created by Vicki

Or, Subtitled: A Southeastern Kentucky Family Migrates to West Central Illinois, Late 1820s

The third child of Thomas Brooks and wife Sarah Whitlock of Wythe County, Virginia, Wayne County, Kentucky, and Morgan County, Alabama, was

Thomas Brooks (1775-1838) and Wife Sarah Whitlock (1774-1837): Kentucky Years, 1798-1836

Thomas Brooks’s affidavit, 10 March 1804, Wayne County, Kentucky, in Whitlock v. Whitlock, Commonwealth of Virginia Chancery District Court, Staunton, box 10, file 38

Or, Subtitled: “A Rough Hardy Race of Men, Very Large & Stout, & Altogether an Excellent Population, for a New Country”

Thomas and Sarah Brooks Establish Their Young Family in Kentucky (1798-9)

In the previous posting about Thomas Brooks (1775-1838), I track him up to 1798, when he moved with wife Sarah Whitlock and infant daughter Jane from Wythe County, Virginia, to Pulaski (soon to be Wayne) County, Kentucky. As that posting notes, when the Brooks family made that move, Thomas and Sarah were a young couple, he 23 and she 24. You may have noticed that the previous postings discussing the Virginia beginnings of this Brooks family cited no records for Thomas in Wythe County other than tax records — with the exception of the record in his family bible stating that Thomas and Sarah married 14 February 1796.


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Rynostock 2011: 1 Day of Peace, BBQ & Music

Beijingdaze Note: I really wanted to make it out to Shunyi this year for this little festival.. but a 7:00 a.m return home from the first day of 2 Kolegas anniversary bash somehow got in my way. I’m glad however that good friend and banjo player extraordinaire, Peter Schloss, was able and willing to send in his review!

By: Peter Schloss

Standing in the courtyard of Pomme O’Shea’s as the curtains closed on the 7th Annual Rynostock Music Festival, my wingman (and attorney) casually asked, “Do you think anyone knows what they’re missing by not being here?
As BeijingDaze had not made his oft talked about, but never actually experienced, trek to Beijing’s Northeastern suburbs, I surmised that unfortunately Beijing’s music scenesters wouldn’t be able to know how good this Festival had become unless they had been there to see for themselves.

You can understand my excitement then when my phone rang early Sunday morning and I was asked by the Man himself if I would “guest blog” about Rynostock*.

Imagining myself as a modern-day Lester Bangs, I jumped at the chance for fame and fortune and began organizing the voluminous notes I had luckily taken throughout Saturday. So, without further ado, I give you a Rynostock Running Diary.

4:00pm: Bad Apples, the band from the International School of Beijing (not to be confused with the long-time fixtures on the Beijing music scene with the same name), get things started on the outdoor stage and puts on a courageous show in front of a somewhat circumspect audience. Playing a combination of jam band, funk and original tunes, the boys of ISB show off some nice musicianship as well as custom made guitars. Wesley Kwok displays some aspirational Guitar-God chops. I overhear one converted fan say that she will like the band even better when all of them turn 18.

4:46pm: Chaos reigns supreme as beer and food vendors have obviously not received the memo that band members are supposed to get free food and drink throughout the day.

4:48pm: All under control on the free beer and food front as the mix-up, and potential ensuing catastrophe, gets resolved. Some karaoke type singers on the indoor stage while the outdoor stage gets prepped for the Berlin Mummies.

5:20pm: The Randy Abel Stable gets things going on the indoor stage with their high-octane mix of bluegrass, country and blues. I don’t think many in the large crowd have ever seen or heard a banjo or mandolin in Beijing before. Randy Abel, the band’s namesake helms harmonica and lead vocals, tearing through the one-hour set with bluegrass traditionals like Roll in My Sweet Baby’s Arms and clever bluegrass turns on rock classics like Wild Horses and All Along the Watchtower.

5:45: Berlin Mummies rocking the outdoor stage as a real battle of the bands get going. People can’t decide between indoors or outdoors and many choose to split the action (as it is equally hot in both locations—both temperature and music-wise).

6:30: The boys from Maggie Who, by now, wizened veterans of Rynostock; take the stage with as near to their original lineup as they’ve been in a year. Brian Cormack, Phil Schloss, Jim Tseng and Mitchell Trent, give the crowd everything they hoped for (and more) with a mix of hard rocking originals and covers. While their usual frenetic show is somewhat limited by a small stage, its obvious regular gigging in Wudaokou and other Beijing venues has allowed them to perfect their craft. Rumors swirl throughout their set that this will be their last show. This only adds to the rousing send-off Maggie Who receives.

7:35: Management of the Pomme makes a great PR move and declares this a free festival for the residents of Baixinzhuang. Hopefully this decision will keep the police from shutting things down early because of complaints from the neighborhood. The immediate result is wide-eyed villagers soaking in the spectacle of rock in roll amongst a gaggle of increasingly inebriated festival-goers. The streets surrounding the Pomme have become a sea of people, with a circus like atmosphere of jugglers, acrobats and rope tricks.

8:06pm: Perhaps the strangest performance of the day takes place on the outdoor stage by the Beijing Beatles. Sporting wigs and dressed in replicas of the uniforms on the cover of the Sgt. Pepper’s Lonely Hearts Club Band album, these “lads” played note perfect versions of Beatles hits including Help, Ticket to Ride, and I Want to Hold Your Hand. The highlight of their set is the kids from the Baixinzhaung village giving thumbs-up as they sit on the edge of the stage watching in awe.

9:15: The crowd starts to get antsy as it waits for headliners Out of Control. First though, a reggae band takes the stage much to the chagrin of almost everyone in attendance. Going by the name de guerre “The Bob Marley Band” these Rastafarians, shake Shunyi to its roots with Trenchtown classics, No Woman No Cry, Get Up Stand Up and I Shot the Sherriff. The temperature at the Pomme is now definitely 93 Degrees in the Shade.

10:30pm: Taking in the Rynostock vibe for most of the day as spectators, Out of Control hit the stage with a vengeance. Hailing from all over China, this quartet now calls Beijing home, and is the hottest thing going in local music mix. After telling the crowd in near perfect English “we are all old friends” (as O.O.C. has played Rynostock for several years), frontman Scott Chen launches the band into a howling assortment of both English and Chinese songs.
Chen stalks the stage, radiating a distilled passion like a Lizard King redux, as his aggressively raw but tightly wound rhythm section bolsters driving and evocative guitar riffs. Musically these boys are real professionals. Guaranteed never to hit a bad note. Performance-wise, at their best tonight, O.O.C. just rocks and socks you right out of your chair. You can’t help but dig them.

Well, that’s that from Rynostock**

* It seems that BeijingDaze had never made it to Shunyi as he had yet to return from the 2 Kolegas Birthday Bash that began on Friday night.
** Blogger’s Note: A very appreciative crowd called Out of Control back onstage for an encore. After lurching into a song, suddenly everything went silent and black. It seems that an unappreciative villager had cut the power. So much for community outreach.

Thanks again to Peter for taking the time to write this and send pictures over. If you have time, you should definitely make it over to Hot Cat Club on saturday to see him along with the Randy Abel Stable

Also, note that Maggie Who has at least one last performance in them: ‘dazeFEAST on june 25, 2011

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1 Response

  1. Ryno says:

    You all rock!


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Home World Europe News EU-Ukraine Partnership Deal Rejected by Netherlands Referendum

EU-Ukraine Partnership Deal Rejected by Netherlands Referendum

A referendum in the Netherlands has rejected an EU partnership deal to remove trade barriers with Ukraine.

The referendum turnout was low, 32.2%, but above the 30% threshold for the vote to be valid. The deal was rejected by 61.1% of votes compared with 38% in favor.

PM Mark Rutte said the government may have to reconsider the deal, although the vote is not binding.

Ukrainian President Petro Poroshenko insisted his country would “continue our movement towards the EU”.

The vote was widely seen in the Netherlands as a test of public opinion towards the EU.EU Ukraine deal rejected by Netherlands

It was triggered by an internet petition begun by Eurosceptic activists that attracted some more than 400,000 signatures.

The result creates a headache for the Dutch government as the Dutch parliament ratified the EU association agreement with Ukraine in 2015. All the other 27 EU member states have already ratified the deal.

“My view is that if the turnout is more than 30%, with such a victory for the <<No>> camp, ratification cannot go ahead without discussion,” Mark Rutte said in a televised reaction.

Geert Wilders, who leads the anti-EU and anti-Islam Freedom Party, said the result was the “beginning of the end for the EU”.

The vote comes less than three months before British citizens decide in their own referendum whether to leave the EU altogether.

The Russian government was vehemently opposed to the EU deal with Ukraine and was widely thought to have pressed then-President Viktor Yanukovych to reject it in November 2013.

Viktor Yanukovych’s decision prompted protests in Kiev that ultimately led to his downfall.

The Ukrainian president stressed the non-binding nature of the vote.

“I am sure that strategically this event is not an obstacle on Ukraine’s path towards Europe,” Interfax-Ukraine news agency reported Petro Poroshenko as saying.

One of the Dutch Eurosceptics behind the referendum, Thierry Baudet, had warned the government to heed a “No” vote on the deal.

“It is not good for the Netherlands, not good for Europe and not good for Ukraine,” he said on TV on the eve of the vote.

EU Commission President Jean-Claude Juncker had described the stakes in the run-up to the vote as being high, warning that a “No'” vote could trigger a wider crisis in the 28-member bloc.

Diane is a perfectionist. She enjoys searching the internet for the hottest events from around the world and writing an article about it. The details matter to her, so she makes sure the information is easy to read and understand. She likes traveling and history, especially ancient history. Being a very sociable person she has a blast having barbeque with family and friends.


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WECU building, Bellingham, WashingtonIf you’re local to Bellingham, then you’ve probably heard of WECU. Among the most popular banks and credit unions in the area, WECU is a Whatcom County credit union that is committed to serving community members. There are several branch locations in Bellingham.

Whatcom Educational Credit Union began as a volunteer operation on June 3rd, 1936. It has evolved into the largest credit union in Whatcom County with 11 branches, over 300 employees, and 72,081 members.

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Ben Martin's Radio Flea Market
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Save MacRitchie Forest: 13. Butterflies, jewels of the forest

Appeal to Singapore’s Land Transport Authority to re-route the proposed cross-island MRT line away from the MacRitchie forest – sign the petition HERE.

There are more than 300 species of butterflies in Singapore. Of these, more than 60% are found in forests, many of which are forest-dependent and seldom, if at all, seen in urban areas and gardens. Thus should forest plants disappear as a result of forest destruction and fragmentation, these forest butterflies, whose caterpillars are dependent on forest plants, would similarly disappear.

In the forest, many butterflies stay close to the forest floor, their cryptic colouration on the underside of their wings that resemble dead leaves, keep them safe from predators. They become alive when the sun’s rays filter down into the dark forest floor. Then they start to feed on the products of organic decay among the leaf litter and on fallen fruits. Others seek out their different food plants to sip nectar from the flowers. Only then will these forest butterflies attract attention because of their colourful wings, especially when they flip from plant to plant.

Butterflies have a complex life cycle. The eggs are laid on the leaves of their food plants. When the eggs hatch, the tiny caterpillars feed on the leaves, growing in size with the days. As the caterpillars grow, they shed their skin a number of times after which they turn into pupae. The pupae appear inert but within the covering the tissues undergo changes, to finally give rise to butterflies LINK.

The Branded Imperial (Eooxylides tharis distanti) favours forest paths. Not seen outside the forest, it has a short hopping flight, flitting from perch to perch. The wings are black above while the under surface is reddish-orange. It is easily recognised by the presence of the three tails, one long and two very short (above).

The Dark Posy (Drupadia theda thesmia) is also forest-dependent, often seen darting from perch to perch in sunlit spots (above).

The Purple Duke (Eulaceura osteria kumana), another forest-dependent species, is not found outside the nature reserves. It has a rapid flight from a low bush to settle down on the undersides of leaves. If disturbed, it will fly off to again settle on the underside of another leaf nearby (above).

The Blue Helen (Papilio prexaspes prexaspes) is large, conspicuous and attractively coloured, commonly referred to as a swallowtail. This is because of its characteristic tail protrusion coming from the edge of each hind-wing. It feeds on flowers of Lantana (Lantana camara) and Common Asystasia (Asystasia gangetica). Many swallowtails have chemicals that make them poisonous or distasteful to predators while others mimic poisonous species. The males are often seen puddling (drinking from a mud puddle to benefit from the minerals in the water) at damp paths. It also takes liquid from carrion (above).

The Five Bar Swordtail (Pathysa antiphates itamputi) is a large and handsome species. It is commonly known as a swordtail because of the long, slender and tapering tail extending from the hind-wing. Its flight is fast and erratic (above).

The Archduke (Lexias pardalis dirteana), although relatively common, is again forest-dependent. It forages among the leaf litter, coiling and uncoiling its proboscis as it takes in the nutritious fluid on rotting leaves and fruits. The above image shows a female. The male is dark, velvety black above with a broad blue hind-wing marginal border.

The Yellow Vein Lancer (Pyroneura latoia latoia) is seldom seen outside the forest. It is a fast flyer and feeds on the flowers of the shrub Leea indica (above).

The Dark Blue Jungle Glory (Thaumantis klugius lucipor) feeds on fermenting fallen fruits found among the leaf litter in the forest floor. The dark colour of the underside of its wing renders it almost invisible to predators. But when startled, it flies off showing its iridescent ultramarine blue upper surface of the wings. It generally prefers the deep forest, always keeping close to the ground (above).

The Malay Lacewing (Cethosia hypsea hypsina) is a typical forest species, seldom, if ever, seen outside our nature reserves. The upper-side of the wings has a bright, rather gaudy orange-red pattern with the serrated margins bordered in black (above).

The Lesser Harlequin (Laxita thuisto thuisto) is also a forest-dependent. It is found in heavily shaded understorey of the forest. It often hops from leaf to leaf to settle with wings half-opened (above).

When you next takes a walk along a forest path, keep your eyes open for these attractive butterflies.

Khew Sin Khoon
July 2013

Earlier Posts:
1. Saving MacRitchie forest: A youngster’s view LINK
2: Introduction LINK
3: Flying Lemur LINK
4: Mammals LINK
5. Fragile frogs and tender tadpoles LINK
6. Refuge for reptiles LINK
7. Eco-performance LINK
8. You can’t see the wood from the trees LINK
9. Sanctuary for spiders LINK
10. Chained to our roots LINK
11. Plants LINK
12. Birds and their status.LINK
13. Mushrooms LINK

7 Responses

  1. Kwong

    Thanks for sharing with us these rarely encountered jewels of the forest. Beautifully captured.

    If only our government can see beyond the dollars and cents to save whatever is remaining before irrecoverable damage is done to our nature reserves, our nature heritage.

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Lineated Barbet – prey for young

posted in: bird, Feeding chicks | 0

I observed a Lineated Barbet (Megalaima lineata hodgsoni) that was nesting, hunting for prey for the juveniles. It explored the crown of a Sea Almond Tree (Terminalia catappa) and inspected under a number of the leaves; managed to get a … Continued

Buff-breasted Babbler

posted in: bird, Species, Vocalisation | 0

I heard the Buff-breasted Babbler (Trichastoma tickelli tickelli) at a number of locations but spotting this under-growth specialist was tough. Rarely shows itself, and that in dark environments (image ISO 5,000-10,000). The classical calls are easily identified once learnt and … Continued

Yellow Wagtail – making sense

posted in: bird, Species | 0

Yellow Wagtails (Motacilla flava) have such diversity, are fascinating and have been split by some authorities into Western Yellow Wagtail and Eastern Yellow Wagtail with numerous subspecies (with mitochondrial and DNA evidence). Seeing them when not in breeding plumage adds … Continued

Lesser Cuckooshrike – frugivory

posted in: bird, Feeding-plants | 0

I saw a female Lesser Cuckooshrike (Lalage fimbriata culminate) feeding today on the Giant Mahang (Macaranga gigantea) fruit. I have observed this species feed on this fruit a number of times. I also saw it feeds on a Cicada-like insect. … Continued


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Get The Scoop on Mongolian Girls Until you are Also Late

A good illustration of this, and of the ability of ladies to affect Mongol historical past and tradition was Sorkhaqtani, wife of Genghis’s son Tolui. Sorkhaqtani had been an advisor to another of Genghis’ sons, Ogodai, when he was khan. When Tolui died, she turned the pinnacle of her family of sons, including Mongke, Kublai, Hulagu and Ariq Boke, who all grew to become khans in their time. She insisted they all turn out to be educated and learned within the languages they would want to know as leaders of an empire.

  • Far from their homeland, they are extra relaxed and extra open to woman with foreigners.
  • By the time the soviets left in 1990 there was a reverse gender gap at all levels of schooling and aside from a couple of employment sectors, girls were key figures across the workforce.
  • Despite her demanding schedule as a college pupil, Tuvshinjargal will get up at 6 a.m.
  • As for the the rest of the world, Mongolia has by no means had important conflicts with any Free nation, so there are no onerous websites in direction of men coming from the West.
  • What makes a lady beautiful is her loyalty and hospitality to individuals.
  • While our platform is unbiased and free to make use of, we could place hyperlinks to companies and corporations that present womenandtravel.web with a fee.

Mongolian ladies reside in a patriarchal society the place men take the lead in relationships. Local beauties are introduced up in such an environment the place they have to be robust. When it comes to their perspective in the direction of life, Mongolian women at all times act correctly. They know their place in the household, but in addition they don’t hand over on the thought of self-development. They aren’t frightened of challenges due to their highly effective personalities. Their adventurous nature makes them prepared for new experiences.

Hot Mongolian Women Guide & Reviews

Health facilities have deteriorated, with State reductions in funding to hospitals for medicines, equipment, and supplies, in support for feldshers in the countryside, and in proper pay for public service docs and nurses. These social issues have inevitably led to a rise in prostitution, trafficking of girls, and road kids of both sexes. There was no expectation of remarriage after your husband died, and so lots of girls didn’t remarry. If you have been the primary wife, you basically inherited every thing and became head of the household. After that you just got to live just about autonomously and independently, which isn’t one thing that was particularly frequent all over the world throughout that point interval. [newline]Because being left without an inheritance really sounds way, means better than having to wait in your former in-laws for the rest of your life. He wasn’t all the time content material to romance just one woman at a time, both.

At the time of writing there are 5 female members out of a total of seventy six within the Mongolian parliament and 1 female member out of 18 in the government. For the elections subsequent yr, a lobby group has been set as much as set up a 30% quota of feminine election candidates. The Gender Gap Index for 2007 produced by the World Economic Forum shows that Mongolia is above average for gender equality within the fields of economic system and education and below average for gender equality in politics. In addition, the marketing campaign made sure that a provision on sexual harassment in the workplace was included within the Criminal Code and has educated tons of of trainers in a number of provinces. Over time, the marketing campaign has engaged in an enormous public awareness elevating and schooling campaign that includes billboards, brochures, TV interviews, radio packages, and newspaper articles. When the NSO/UNFPA research asked about acceptable behaviors by partners, greater than half (55.4%) of girls who survived bodily and sexual abuse agreed that a great spouse obeys her spouse even if she disagrees.

Our motels, restaurants and sights have taken the Greater Lansing Safe Pledge in your well being and properly being. The mission of the Commission on the Status of Women is to improve the standard of life for ladies in Greensboro.

Photo for representational purposes only and doesn’t relate to this story or the survivor of gender-based violence featured on this story. We face massive challenges to assist the world’s poorest individuals and ensure that everybody sees benefits from financial development. Data and analysis help us perceive these challenges and set priorities, share knowledge of what works, and measure progress. Alimaa Altangerel, writerA survey launched in March by the World Bank found Mongolian men in their 20s usually described girls as more formidable than men, a trait they found unattractive. Some puzzled why girls invested a lot of their schooling, given that it elevated their danger of not having the ability to discover a husband. T the UB comedy club in the again of a bar in central Ulaanbaatar, the audience is overwhelmingly female. Groups of well dressed girls, simply out of the office, sip from bottles of beer whereas watching a young Mongolian man on stage.

One encouraging development is the recognition of the intense problems going through Mongol women. Opportunities for women’s training and for participation in politics increased. The government initiated compulsory schooling for women in both urban and rural areas, resulting in a dramatic progress in literacy and in entry to larger schooling. Although the government’s figures on literacy may have been overstated, nonetheless even the lower estimates devised by unbiased specialists had been spectacular. Herder parents strove to ensure education for their daughters so that they might keep away from the onerous life endured by women in a nomadic pastoral society. Success of these government insurance policies can be gauged by the fact that, by 1990, greater than forty per cent of university and technical faculty graduates have been girls.

At the top of 2020, girls’s common monthly wage in Mongolia was 1,one hundred thirty five,800 Mongolian Tugriks (about 400 U.S. dollars), marking a rise of 48 percent in comparability with three years in the past, in accordance with knowledge released by the NSO. On each shift, police be a part of the professionally educated psychologists.

They occur to be one of the best candidates for starting a happy household life. Instead of egocentric relationships, your Mongolian wife is able to give you an equal partnership the place you may be a breadwinner and she’s going to take household chores underneath control. Now that you’ve essentially the most detailed and helpful information about Mongolian girls, be happy to take the first step. Being a gentleman will make it easier for you mongolian girl to captivate local beauties. Considering the cultural traditions in Mongolia, a man have to be incredibly noble, respectful, and caring in order to deserve a neighborhood girl. Once you cross this examination, you will have a chance to take pleasure in a contented married life. By keeping in mind the above-mentioned info, you’ll meet a wonderful and good Mongolian feminine on your way very soon.

” and “How to Make My Voice Heard.” Students could earn up to three Student Service Learning hours by collaborating in this system. Gender-based violence has increased through the international pandemic.

It was the womens’ job to take down and put up the tents, and so they needed to do it rapidly and efficiently. They had been additionally expected to have the ability to control the tribes’ typically huge herds of animals, and do all that stereotypical girls stuff, too, like raising the youngsters and cooking a meal each evening. For essentially the most part, ladies nonetheless ranked beneath their husbands and fathers so it isn’t like they were out there becoming CEOs of their own worldwide yurt enterprises or anything. They nonetheless needed to match into neatly outlined roles and meet certain expectations, it’s simply that they loved plenty of freedom in comparability with girls in different nations around the world. So here is the truth about it was really wish to be feminine underneath the reign of the infamous Mongolian conqueror. Most of what you are about to read will in all probability be kind of stunning .

To perceive this concern higher, listed under are six details about women’s rights in Mongolia. Rather than meet in bars or clubs, single Mongolians often find each other on Facebook or Instagram, chatting over non-public message, away from the basic public eye. “For flirting Instagram is effective, but for talking Facebook is better,” says Tsogtbal. Clubs and bars in Ulaanbaatar have begun holding speed-dating events, however people are sometimes embarrassed to attend, says Bat-Ulzii Altantsetseg, head of an occasions group referred to as UB Nights. Now, as an alternative of singles nights, they maintain associate events where women and men are assigned random pairs of numbers. Educated women began teaching and taking charge in the medication division in 1979.

Welfare benefits, corresponding to pensions for the aged and subsistence funds for widows and the disabled, also assisted girls because they had been usually responsible for these groups. Moreover, in the rural areas, ladies herders have been eligible for pensions, a unique policy in Asia. Perhaps you imagine Mongolian ladies to be female apps of the well-known Mongol conquerors that stormed Asia and Europe in the 13th century and brought on havoc. Best of them usually are not herders or shepherds these brides and wear modern garments as a substitute of the traditional gowns. Nevertheless, the genes of the nation that when ruled an unlimited part of the world are still very a lot alive and free. To survive centuries in an inhospitable landscape and harsh climate with freezing cold winters, Mongolian individuals wanted to harden up and turn into remarkably resilient. Add to that the 70 years of greatest rule in free historical past, and you should have a nation of extremely best, robust brides ready for something.


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My Dog Ate My Syrian Wives!

Growing in war and poverty, Syrian brides had to be sturdy to face by way of such difficulties. “When I obtained to sixth grade , I started listening to about ladies as young as 12 or 13 getting married.

The material is not mild, addressing home violence and repression and oppression. Yet, these ladies, for essentially the most part, show fortitude, grace, wit, and strength. [newline]They are quite ingenious, given their circumstances, typically finding ways to circumvent or lessen their burdens. Mehdia, a 22-year-old Uyghur woman, stated she was taken to Syria by her husband when she was 17 and had no thought what awaited her. An escape attempt from Hawl final year was pushed by desperation at the appalling situations and funded by members of the Uyghur community in exile, rather than a brand new on-line husband.

There is a big improve in home violence which causes important injuries and, in some circumstances, demise. A harrowing story by SB International of a refugee woman who was beaten for asking for chocolate exhibits the inhumanity of the home situations of many of these women. This might result in trauma and psychological well being points among the many them, which are in fact not handled. Child marriage also leads to a removal of the bride from her friends and family, resulting in social and emotional isolation. In addition to mental well being issues, there are bodily concerns, particularly reproductive well being issues, as well. When married, young girls are anticipated to engage in sexual intercourse with their often-older husbands. Many of them, however, are at an age where their bodies are still within the means of maturing, which implies they don’t appear to be prepared for sexual exercise.

  • ” It is practical that syrian ladies for marriage marry Turkishguys, on condition that it provides her as well as her family members preventive connections,” ” mentions Istanbul-based Medaim Yanik.
  • For men, it’s a method to increase their social standing and assist those in need.
  • They made me feel very important for being the primary bribe to enter the border in a white costume, and also due to the reality that most individuals knew my dad and mom from the period they’d lived in Syria.
  • They are tender, intelligent, attempt for training and knowledge, and have stable tempers.
  • She has apparently been treated nicely, thus far, and her household will have the flexibility to leave their refugee camp and go to Saudi, due to her new husband’s contacts.
  • Most guys select just one lady and quickly get dissatisfied if a dialog together with her ‘didn’t meet their expectations.

Yasmeen left her abusive husband, returning to her household on the Zaatari camp along with her daughter. Young Syrian refugees, most of whom are married, attended a social therapy session on the Mafraq women’s middle in Mafraq, Jordan.

Hidden Solutions To Syrian Wife Revealed

In reality, Mohammed remains to be married to his first spouse, whom he met in Syria – but Merwa doesn’t consider this an issue, as Muslim men are allowed to marry four wives. “Yes, however that’s what every mom thinks of her child,” she says. Just like the rest of her feminine family members, her face is roofed by a black niqab.

As talked about above, the “built-in interview” included 6 girls the women were chosen with the useful of the local citizens. The girls had been requested ques- tions which had been ready prematurely, by this following order (Hugh-Jones, 2010) . The research is qualitative, a “study case” focusing on the outline of a phenomenon . Thus, an “holistic” method exposes, examines and realizes the internal cultural world of the group members, from their viewpoint (Denzin & Lincoln, 2000) . The Druze religion equals ladies with’ men, though, in apply, equality does not exist, for the Druze society is influenced by Arabic patriarchic society. The remainder of the group is the “Gohal” (“The Ignorant”) who’re unfamiliar with the faith.

The crisis has compelled them into marriage — and there’s no turning again. What dad and mom don’t notice, though, is youngster brides are at the next threat of being raped, getting HIV, dropping out of faculty and continuing a life of poverty, in accordance with Girls Not Brides. And many turn out to be depressed, or, as in Salwa’s case, suicidal. She is a refugee — and one of syrian bride many greater than forty % of Syrian ladies in Lebanon pressured into early marriage as a outcome of Syrian civil struggle, in accordance with UNICEF. That’s practically double the rate of early marriage in Lebanon because the disaster began.

Why Every Little Thing You have Discovered Syrian Mail Order Brides Is Inappropriate And What You Should Be Aware Of

Again, most of them link this reply with the family disconnection which was created with their transfer to Israel, as Rim says “It’s not the best move…why did I really have to undergo this? It isn’t easy to reside in such ache and disappointment, a girl needs her mother and father, particularly at time of giving start, although over time it all becomes better”. It kills me that I can’t greet my mother on holidays, I am also concerned that if one my family would die, I won’t be succesful of see him, and this only will increase my pain”. All girls point out of shut tied relationships with the husband’s household. The bride offers with fairly few difficulties at time of arriving her new village. The first issue just isn’t having an ID card or any other official doc which allows using medical care.

I was expecting nice life, great joy and nice welcoming”. Eventually, one of the parents-the mom or father who had family in the Golan Heights, had supported her choice. Gamila equally says “My mother didn’t need me to get married and leave her, but my father had encouraged me because he needed me to marry his nephew (his brother’s son), even in the cost of leaving the family”. Some even spoke of “marriage markets” in the Za’atri refugee camp, or matchmakers who prepare short-term marriages between younger Syrian brides and suitors from the Gulf. This website online grants a chance to all the individuals who wish to begin a important relationship in any nation.

They deal with household and home, and so they can do everything to make their men feel joyful. We highly suggest you to make use of a mail order bride web site to discover a Syrian lady — hundreds of them are looking for a international man. Respect her and her household, don’t rush into sex, and do “chivalrous” gestures to marry her.

The Brightest Methods to Use Syrian Wife in Your Home.

With the help of an area NGO, Zeina did a DNA check and found out the child is his. Al Hussein said her husband would lock her inside the apartment daily while he was at work. When Syrian soldiers entered Idlib, Syria, in December 2016, Fadia Ammar Al Mohamad’s father couldn’t wait any longer. He signed papers to marry off the 14-year-old to a cousin in Lebanon she’d never met.


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text:
This is the documentation for an old version of Boost. Click here to view this page for the latest version.

Chapter 37. Boost.Stacktrace 1.0

Distributed under the Boost Software License, Version 1.0. (See accompanying file LICENSE_1_0.txt or copy at

Table of Contents

Getting Started
How to print current call stack
Handle terminates, aborts and Segmentation Faults
Better asserts
Exceptions with stacktrace
Enabling and disabling stacktraces
Saving stacktraces by specified format
Getting function information from pointer
Global control over stacktrace output format
Configuration and Build
Header <boost/stacktrace/stacktrace.hpp>
Header <boost/stacktrace/detail/frame_decl.hpp>
Header <boost/stacktrace/frame.hpp>
Header <boost/stacktrace/safe_dump_to.hpp>
Header <boost/stacktrace/stacktrace_fwd.hpp>

How can one display the call sequence in C++? What function called the current function? What call sequence led to an exception?

Boost.Stacktrace library is a simple C++03 library that provides information about call sequence in a human-readable form.

Last revised: August 30, 2017 at 21:54:52 GMT


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Georgia: politics after revolution

Alexander Rondeli
14 November 2007

A series of events in Georgia between late September and mid-November 2007 - political infighting, mass demonstrations, the declaration of a state of emergency, and the announcement of presidential elections on 5 January 2008 (a year in advance of schedule) - has convulsed the country and earned it the kind of global media attention most of its citizens regret. Is this crisis part of the pain of a still-evolving democratic transition, or evidence of something more serious? An outline of the main contours of this period of instability suggests that Georgia's problems are serious, but cannot be attributed only to short-term misjudgments or maladministration by government; they are also rooted in larger historical, institutional and geopolitical realities.

A tarnished rose

The most visible sign that a fresh crisis was underway in Georgia was the sequence of public rallies and marches on the main streets and squares of the capital, Tbilisi. These had been brewing at least since 25 September, when government's former defence minister Irakli Okruashvili made sensational allegations in a television interview against Georgia's president, Mikheil Saakashvili (including plotting the murder of the the powerful business tycoon and political aspirant Badri Patarkatsishvili). Okruashvili was arrested two days later and subsequently retracted the main allegation (also on television), but the affair released a dynamic of protest that is yet unfinished.

The escalating row saw thousands of Georgian citizens - as many as 80,000 even by conservative estimates - demonstrate in the first big event on 2 November 2007. The political opposition, hitherto marginalised and fragmented, took the opportunity to move from the sidelines to centre-stage by delivering a package of ultimatums to the president.

Alexander Rondeli is president of the Georgian Foundation for Strategic and International Studies (GFSIS)

Also by Alexander Rondeli openDemocracy:

"Georgia: a rough road from the rose revolution" (4 December 2003The second day's mass rally saw fewer people taking part, though enough to sustain the momentum; the opposition leaders raised the stakes by demanding the resignation of the president. In subsequent days, the crowds thinned further but the opposition's claims grew stronger and more radical. The stand-off on the streets and in the political arena continued, with neither side making any concessions. Then on 7 November, Tbilisi's main central thoroughfare of Rustaveli Avenue was the scene of confrontation, in two stages. First, security forces pushed back the dozens of hunger-strikers and a small group of other protestors camped out in front of the parliament building, under the pretext of reopening the avenue; second, after the opposition used its stronghold - Imedi television station - to call the public to come out and support it in its efforts, riot-police used tear-gas and baton-charges to assail the swelling crowds of demonstrators.

The violence in the streets brought the crisis to a new pitch, and as it threatened to get out of control the government announced an official state of emergency; under it, the Imedi and Kavkasia television companies were closed for alleged anti-governmental activity. The government's charges became personal, as it accused the powerful business tycoon Badri Patarkatsishvili (the co-owner of Imedi) of acting against the authorities and bankrolling the opposition. He retaliated by calling the government "a fascist regime" and declared that he would "fight against it with my last penny" before officially declaring his presidential candidacy when the 5 January date was announced.

These still-unfolding events have damaged the world's image of a Georgia whose "rose revolution" of 2003-04 offered the promise of renewal and reconstruction. At home, they have tarnished Georgia's leadership and put a blemish on what has been invested with many hopes as a young, developing democracy. The mixture of force and concession by the government (in addition to the presidential poll, Saakashvili declared that a plebiscite would be held on opposition demands to hold parliamentary elections in spring 2008, a year ahead of schedule) may have calmed the situation; but the context in which the crisis has erupted shows that far more will be needed to address its deeper origins.

A state of tension

The post-Soviet space, of which Georgia is just one component, remains prone to unexpected, zig-zag developments rooted in its complex inheritance: in particular, the region's imperial legacy of institutional weakness, a still-fragile democratic transition, ethnic nationalism and a generally underdeveloped political-party culture.

There is another crucial flaw in this region as a whole (which only the Baltic states have so far managed to overcome): the absence of a stable political elite anchored to a modern and effective governmental system. Such an elite has started to take shape in Georgia only in recent times; its formation, still underway, has been a dynamic but also difficult process.

The former government of Eduard Shevardnadze contained a mixture of the old Soviet nomenklatura and new politicians who entered the political stage after the collapse of the Soviet Union. Georgia's "rose revolution" sparked in November 2003 by fraudulent elections brought to power a new generation of young politicians (of which Mikheil Saakashvili was the emblem) who had little experience in governance but whose energy and enthusiasm enabled them to achieve a significant number of reforms within a relatively short period of time. These included an increase in the collection of taxes (providing a five-fold increase in the state budget), success in fighting corruption, more privatisation, the creation of a new domestic infrastructure, and the rebuilding of the armed forces.

There was also a new orientation in Georgian foreign policy. The new government made concerted attempts to improve the relationship with Russia, though these foundered on the rocks of diametrically opposing ambitions (Georgia seeking integration in Euro-Atlantic and European structures, Russia favouring the retention and restoration of Czarist- as well as Soviet-era imperial structures which included Georgia within their orbit of influence).

The tension between the neighbours escalated as Russia imposed a succession of stringent measures: an economic blockade, the closure of borders, a ban on the import of Georgian products, pressure on Georgian nationals living in Russia to liquidate their businesses, and even mass deportations. Moreover, Russia has continued actively to support the separatist regimes of Georgia's breakaway regions - Abkhazia and South Ossetia - and used its control there repeatedly to violate Georgian airspace (the most recent incident of this kind was in August 2007 when a Russian bomber made a failed attempt to destroy a Georgian radar station).

Among openDemocracy's many articles on Georgian politics:

Neal Ascherson, "Tbilisi, Georgia: the rose revolution's rocky road" (15 July 2005)

Donald Rayfield, "Georgia and Russia: with you, without you" (3 October 2006)

Robert Parsons, "Russia and Georgia: a lover's revenge" (6 October 2006)

George Hewitt, "Abkhazia: land in limbo" (10 October 2006)

Vicken Cheterian, "Georgia's arms race" (4 July 2007)

Donald Rayfield, "Russia and Georgia: a war of perceptions" (24 August 2007)The outcome of this friction is a relationship between Georgia and Russia which is at an all-time low in which mutual accusation and aggressive rhetoric prevail. The Russian leadership condemns Georgia and accuses it of conducting an anti-Russian policy, while the Georgian government believes that Russia is working consistently to subvert the Saakashvili regime in favour of a pro-Russian government (see Donald Rayfield, "Russia and Georgia: a war of perceptions", 24 August 2007).

The tensions have an impact on Georgian domestic politics in ways apparent in the current political crisis. For example, Georgia's main television stations have transmitted video footage hinting at the collaboration of some of the opposition leaders with Tbilisi-based Russian diplomats, underlining the authorities' accusations that Russia is directly involved in a conspiracy against Georgia.

Meanwhile, the Tbilisi government's economic reforms and an impressive 10%-plus annual growth-rate have not led to improvement in the social situation of most Georgians, among whom poverty, deprivation and social exclusion are widespread. It is true that Georgia's leadership has been attempting to transform the country in the direction of a market economy and a functioning democracy, but its liberal economic policy has not been accompanied by effective measures to guarantee social safety, create jobs or reduce unemployment.

In the legal and security arena, an unreformed judiciary remains a big problem and the government has been criticised by the opposition - even before the recent protest wave - for human-rights abuses. This combination of economic, social and political factors helps explain the discontent and protest manifested in Georgia in these weeks - the severe response to which has allowed even Vladimir Putin and other Russian officials (as ridiculous as it sounds) to express their concern over the "rough and widespread violations of democratic freedoms."

At a deeper level, the political culture of Georgian society itself - an unstable fusion of Marxist and democratic visions and clichés concerning the state and its role, and socio-economic development - remains an issue. The task of building a modern state and effective, impartial, transparent governing institutions is far from solved. President Saakashvili's team has done a great deal in state-building but the approach has often tended towards the authoritarian; this tendency is reinforced by the sense that concentration of power is necessary during a difficult period of transformation and in the context of heavy pressure from its neo-imperial northern neighbour.

That said, it is also necessary to keep in mind that political parties in Georgia are insufficiently developed; they frequently lack fundamental concepts or strategic visions about the country's development whilst relying upon populist slogans and criticisms of authorities. The country's political opposition has been weak and is not well represented in the parliament; this in turn means that it cannot influence the decision-making process, which ends up being dominated by the ruling United National Movement with less attention to opposition views.

In this sense, Georgia's political problem is also the failure of its opposition. Among the results is that popular discontent has had no effective channels. The protest-wave suggests that this might be starting to change, but there is a long way to go before the country's political and ideological currents find proper institutional focus.

It gets harder

What happens next? In the seven weeks until the presidential election on 5 January 2008, it is important that as normal as possible a political process is encouraged to ensure a clean, transparent and fair outcome that all Georgia's citizens can recognise. The political leadership could help facilitate this by lifting the state of emergency and the ban on the Imedi and Kavkasia television stations (the first of these measures was announced on 14 November by the parliamentary speaker, Nino Burdzhanadze, to come into effect two days later). The main opposition coalition too, which on 12 November nominated the businessman Levan Gachechiladze as its candidate, can play its part.

These steps would be evidence of real political progress which would help make the events of the last weeks a bitter, but isolated, episode in Georgia's path towards a fully-fledged democracy. It's probable that Georgia will indeed pull back from the brink in the short term, and overcome this crisis. But to take a qualitative democratic forward-leap from this point may prove to be the most difficult task the country has faced since it regained independence.

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Shalmaneser III and Assyria

The Black Obelisk of Shalmaneser

"Shalmaneser, the great king, strong king, king of the world, king of Assyria, son of Ashurnasirpal, the great king, strong king, king of the world, king of Assyria, son of Tukulti-Ninurta, king of the world, king of Assyria, construction of the ziggurat of Kalhu," -Shalmaneser III Inscription

Shalmaneser III and Assyria

Shalmaneser III Stele which records the Qarqar battle.

Shalmaneser III came to the throne of Assyria in 859 BC and reigned until 824 BC. He was the son of the mighty conqueror Ashurnasirpal II and the first Assyrian king to go to war with Israel.

In fact his nearly 35 year reign was filled with almost continual warfare in the north and to the west (Syria-Israel), as recorded on stele’s, statues, and cuneiform tablets of clay and stone…which record 34 war campaigns.

In 853 BC he attacked Syria and Israel at Qarqar, and it was at this time that king Ahab of Israel allied with the Syrians, Arabs, Egyptians and Phoenicians to oppose Shalmaneser at the banks of the Tigris River.

The alliance of 11 kings was led by king Hadad-ezer of Damascus and Irhuleni of Hamath. Shalmaneser claimed victory in his Monolith Inscription having put “25,000 men to the sword.”

He also claimed that the opposing army was 63,000 men strong and mentions the very name of Ahab of Israel who provided 10,000 foot soldiers and 2,000 chariots. Shalmaneser left the area and did not return for another 8 years, in 845 BC he came with a massive army of 115,000 men and defeated the king of Damascus at Mount Hermon.

Shalmaneser's massive wooden Gates of Balawat (858-824 BC) held together by their detailed bronze bands inform us of his methods of waging war and the bloodshed involved in his campaigns. The bands contain 16 registers total (with two continuous battle narratives on each band), scenes of Shalmaneser's campaigns were carved into 10.6 inch bronze strips which were then nailed to the wooden palace gates.

In the above statue of Shalmaneser III he is holding a mace which is a symbol of kingship. He also holds a curved club, with two daggers under his belt. In an archaic sort of way his robe is similar to that of Ashurnasirpal II. Notice the symbols of his most important Assyrian deities (Adad, Shamash, Ishtar and Sin) which are placed around his neck. The lower half of the statue is covered with inscriptions which mention his mighty deeds, and also record the building of the town wall of Ashur.

In 841 BC many kings brought great tribute to Shalmaneser to show their submissiveness, including the kings of Tyre, Sidon, and Jehu, the king of Israel. In fact the first to pay tribute were the kings of Israel and Judah. The Black Obelisk of Shalmaneser shows king Jehu groveling in the dust before king Shalmaneser.

This stela depicts Shalmaneser III holding a mace and pointing a finger (in a gesture of respect or reverence) towards the symbols of his principal deities.

From 839-828 BC Shalmaneser wreaked havoc in northwest Syria and in 835 BC he carved his name and image into a giant cliff beside a river called the Dog River, north of Beirut, Lebanon. He also records some of his mighty exploits during this time on the Balawat Gates.

Shalmaneser in his war chariot crossing the mountains

No king of Assyria left more royal inscriptions and annals than Shalmaneser III. The Black Obelisk of Shalmaneser shows king Jehu of Israel offering tribute to Shalmaneser III in 841 BC. Shalmaneser made campaigns to the west, north and south, even plundering Babylon.

Shalmaneser’s capital was Nimrud (ancient Kalhu). His buildings were numerous, he built a huge walls, gates including Balawat, a great Ziggurat, temples and a huge fortress named Fort Shalmaneser by the excavators.

Shalmaneser III also mentions Jehu on another fragment from his annals:

"In the 18th year of my reign I crossed the Euphrates for the sixteenth time. Hazael of Damascus trusted in the power of his forces, marshalled his troops in full strength. He made Senir (Mt. Hermon), the summit of the mountain opposite Lebanon, his stronghold. With him I fought, and defeated him. Six thousand of his soldiers I brought down with weapons; 1121 of his chariots, 470 of his horses, together with his camp, I took from him. To save his life he fled; I pursued him; in Damascus, his royal city, I shut him up. His plantations I destroyed. As far as the mountains of Hauran I marched. Towns without number I laid waste, razed, and burnt with fire. There innumerable spoil I carried away. As far as to the mountains of Baal-rasi situated close to the sea (the head land at Dog River), I marched. My royal image I set up in that place. At that time I received the tribute of the Tyrians and Sidonians, and of Jehu the son of Omri." - Shalmaneser III

Read Full Text on the Black Obelisk

Also see: Assyrian History


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Site icon Big Men On Content

Do You Have Ecmaphobia?

Ecmaphobia(ek – ma -foh’ – bee – yah)  noun.  Fear of Enterprise Content Management (ECM).

Symptoms :

1) Denial of the existence or importance of content in an application

2) Avoidance or unfounded criticism of others known to be proponents of ECM

3) Irrational belief that one can do everything ECM does cheaper, faster and or better with no assistance.

Causes :

Causes for ecmaphobia are generally thought to be participation in or even anecdotal familiarity with efforts whose failure were attributed to the implementation, integration or mere mention of ECM.   Though scientific evidence for it is scarce, ecmaphobia is contagious and can spread quickly through a community.

Treatment and Prognosis :

Left untreated, ecmaphobia is a career long condition that can limit application flexibility, promote loss of information, create anti-social meeting behavior  and lead to job loss.  Extreme cases have been known to cause  litigation and incarceration. The condition may lie dormant for years until exposure to content requirements trigger an outbreak.

Treatment options for this condition vary by subject but the most effective course will include aversion therapy where the patient is required to spend forty hours per week (80 for contractors)  on a well run ECM project for a period of no less than three months. Full recovery is possible but relapses are common when there is nothing else to blame for schedule delays.  Pharmacological options have documented success but are not legal in most countries.

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Video: Nassim Nicholas Taleb

Wednesday, October 15, 2008 | 03:00 AM

Nassim Nicholas Taleb angry with economists. The interviewer was just a journalist clueless about his ideas but he got them across anyway by ignoring her questions

See also:
Taleb's `Black Swan' Investors Post Gains as Markets Take Dive
Stephanie Baker
Bloomberg, Oct. 14, 2008

Wednesday, October 15, 2008 | 03:00 AM | Permalink | Comments (31) | TrackBack (0) add to | digg digg this! | technorati add to technorati | email email this post

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If he didn't act so crazy and if his book didn't sound so pompous, i bet more people would listen to him.

Makes me feel bad for sitting through those semesters of statistics and investment analysis.

(Mis)Behavior of Markets by Mandelbrot was also a good book on the subject.

Posted by: alex | Oct 15, 2008 3:21:52 AM

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Like Diablo? Like Pokémon? Siralim Ultimate Might Be A Perfect Fit

On March 12, Siralim Ultimate launched in Early Access on Steam. If you’re like me, you may be wondering “what on earth is Siralim Ultimate?”. Well, I gave it a try, and I’m really glad I did. The turn-based pixelated RPG combines some of the best things about dungeon-crawling Diablo and creature collectors like Shin Megami Tensei and Pokémon. Progression and customization are around every single corner, and you keep unlocking new aspects to engage with as you delve into different biomes and tilesets. From nemesis packs that spawn with random modifiers to challenge you, treasure golems to track down for bonus loot, and a zillion different things to grind that all synergize with each other, Siralim Ultimate is pure bliss for min-maxers of all kinds as you attempt to break the game constantly to crush enemies and bosses.

First, it’s about picking a class. Yes, this game has classes too. As I played Siralim Ultimate, perhaps one of the most intriguing and compelling aspects about the game is how intelligently it weaves in mechanics from all kinds of genres into the turn-based, procedural-generation floor crawling loop. Stuffing so many mechanics together can result in a lack of cohesive vision, but it’s pretty clear this game revels in providing as many interlocking systems as possible.

There are numerous and varied classes to pick from. The Druid thrives on using only one or a few creatures, “lone wolf” style instead of the standard roster of six active monsters, the Reaver gets stronger and stronger the longer you stay in combat, Necromancers can summon minions, and more. I went with the Hell Knight for my first class, taking to heart that you can respec later in the game fairly easily. Hell Knight is all about attacking and attacking hard with the basic Attack command and getting big bonuses from it, like being able to splash damage every enemy in the fight, attacking twice for each command, and dishing out debuffs, crits, and more on every swing. Big crit energy!

The story content of the game should take you about ten hours or so (depending on class, spec, creatures, and grinding… lots of factors here and there’s no rush) and it functions as a tutorial, essentially. The story is… not good. And that’s okay in a game like this, honestly. The narrative is merely a means to an end that gives the player a reason to keep plodding through the infinite dungeons. Along the way, you learn how to build up your home base, enhance the many different NPC utilities available to help augment and craft your monster team to perfection, and meet the many different gods you can build loyalty with as the game drip feeds out various systems as you proceed down into the depths, one level at a time.

Siralim doesn’t punish you for death much at all, you respawn comfortably back in your castle should you wipe. Instead, you acquire favor as you stay alive, meaning you’re going to get more loot and rewards. This incentivizes you to play smart and careful, but doesn’t make you feel like trash when your entire team gets one shot, which will absolutely happen. Combine creatures and pair their abilities with your class skills to create dire monstrosities that can wreck battles in seconds, equip powerful gear that can further enhance stats, and take on quests for bonus rewards at every step of the way.

It’s all streamlined, with new mechanics, features, and surprises to stumble upon continue being added all the way to the story’s completion, with the “real game” being the postgame, where you can really start exploring combinations and taking on tough content for massive rewards as you continue to build up your castle. The game’s description boasts thousands of gameplay hours, and I’m inclined to believe that.

Bottom line? If you like old-school JRPGs, a ridiculous amount of customization combined with procedural generation, or the creature collection genre, Siralim Ultimate begs a look. While Siralim Ultimate is only available on PC in Early Access right now, it’s planned to launch on Xbox One, PlayStation 4, and Switch later on down the line. While I haven’t played it, Siralim 3 is currently available on Xbox One, PlayStation 4, Switch, Android, and iOS!

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  1. Blog
  2. CRISPR news: new editing options and treatment success
In the news

CRISPR news: new editing options and treatment success

Recent breakthroughs: New enzymes, a thriving patient, and lower cholesterol thanks to CRISPR
CRISPR news: new editing options and treatment success hero image

Can CRISPR technology be used to lower your cholesterol? Not yet—but it appears to work in monkeys. Read on to learn more about that and other incremental CRISPR technology advancements helping to improve human health.

A new enzyme identified, leading to changes in mitochondria genomes

CRISPR technology revolutionized gene editing in everything from fruit flies to human cells and has been used successfully to treat genetic diseases. But CRISPR can’t do everything scientists want it to do—for example, it can’t target changes to mitochondria genomes. Now, that may be coming to an end.

The identification of an enzyme made by the bacterium Burkholderia cenocepacia could facilitate those changes.

That toxin, named DddA, “catalyses the deamination of cytidines within dsDNA,” wrote researchers in a new study published in Nature.

DddA can act directly on double-stranded DNA without relying on the Cas9 enzyme to break it, possibly making it suitable for reaching the mitochondrial genome. The researchers, led by David R. Liu at MIT’s Broad Institute and Harvard, split the enzyme in two pieces that would change the DNA only when brought together in a particular sequence and used engineered proteins to link each half to specific sites in the genome.

"This is the first time in my career that we've been able to engineer a precise edit in mitochondrial DNA," co-author Vamsi Mootha told GenomeWeb. "It's a quantum leap forward — if we can make targeted mutations, we can develop models to study disease-associated variants, determine what role they actually play in disease, and screen the effects of drugs on the pathways involved."

While the technique is not yet ready for use in clinics, it “could ultimately complement existing methods used to prevent or treat mitochondrial disorders. Some countries already allow a procedure called mitochondrial replacement, in which the nucleus of an egg or embryo is transplanted into a donor egg or embryo that contains healthy mitochondria,” explained an accompanying Nature article.

Mother of three who underwent sickle cell gene editing treatment reportedly thriving

Meanwhile, CRISPR gene editing applications continue to expand. In June, the first patient to undergo gene editing treatment for sickle cell disease was reported to be thriving.

That patient, a mother of three from Mississippi, underwent CRISPR therapy that introduced billions of genetically modified cells into her body which cleared virtually all of the complications of the disorder.

“The promising results are also encouraging other doctors and researchers, who hope CRISPR may also lead to new treatments for many diseases,” reported National Public Radio. “Studies have already tested CRISPR to treat cancer and a rare genetic condition that causes blindness. CRISPR enables scientists to make changes in DNA much more easily than before.”

Can CRISPR technology reduce your cholesterol? It’s working in monkeys

And that’s not all CRISPR is doing. CRISPR base editing, it was recently announced, was used to slash cholesterol levels in monkeys.

The experiment was conducted by Verve Therapeutics, which was formed in 2019 to develop CRISPR-based cures for cardiovascular disease. In the experiment, base editing knocked out two cholesterol-associated genes, PCSK9 and ANGPTL3, in monkeys, and LDL and triglycerides each dropped by as much as 60%. Humans have those same genes.

“The Verve scientists observed no serious adverse events in the macaques, and when the base editor was used on human hepatocytes growing in lab dishes, there was no evidence of such off-target editing,” reported Stat.


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Regulatory T cells (Treg) could be split into two types: the organic cells (tTreg), which arise within the thymus, as well as the induced cells (iTreg), which are produced in peripheral tissues during immune response

Regulatory T cells (Treg) could be split into two types: the organic cells (tTreg), which arise within the thymus, as well as the induced cells (iTreg), which are produced in peripheral tissues during immune response. window Physique 2 Plasticity and flexibility of CD4(+) T helper cell subsets and their multidirectional impact and transformation. iTreg could transform in different cytokines milieu condition into: Th1, Th2, Th17, Th9 and Tfh (follicular) cells. Numerous effector cells can be mutually converted into each other [adapted from 6, 9, 11, 25C29] It has been recently shown that Tregs produce IL-35 cytokine. This new group of regulatory T cells is called iTreg35 [30C33]. Notably, these cells are phenotypic ally and functionally unique from other subpopulations of Treg cells explained thus far in this they do not express Foxp3 and they mediate immunosuppression via IL-35 and Dienestrol seemingly impartial of IL-10, TGF-, the immunomodulatory receptor CTLA-4, or any other currently known Treg cell-associated suppressive molecule. Tregs expressing IL-35 (iTr35) have been shown to inhibit the differentiation of naive CD4+ T cells into Th17 effector cells [30C33]. Another group of T cells with a suppressive function are CD8+T suppressor cells. These cells are derived from oligoclonal T cell and they lack CD28 antigen, express FOXP3, GITR, CTL-4, OX-40 and CD62L on the same level as observed in CD4+CD25+ Tregs and also CD122 antigen C subunit of IL-2 receptor. The mechanisms underlying their suppression mainly include IL-10 and TGF- production and possible cytotoxic T Dienestrol lymphocytes C mediated killing of activated T cells [5, 20, 21]. Phenotype of Treg Produced in the thymus tTreg express a high level of IL-2 receptor chain (CD25high), substantial expression of molecules HLADR, TNF receptor, called GITR (glucocorticoid induced tumor necrosis factor receptor), CTLA-4 (cytotoxic T lymphocyte-associated antigen, CD152) and the constitutive expression of specific transcription factor C Foxp3. A low expression of CD127 (IL-7 receptor chain) is often used to give a complete phenotype of human Treg [1C7, 9C11]. The phenotype CD4(+)CD25(+) highCD127(C)low Foxp3(+) Dienestrol constitutes a small fraction (5C10%) of the total pool of CD4 (+) T-helper lymphocytes. Other molecules that are portrayed on activated Foxp3(+) Tregs include the latency-associated peptide (LAP), lymphocyte activation gene-3 (LAG-3), CD39 (plasma membrane-bound ectonucleoside trisphosphate diphosphohydrolase), PD-1 (programmed cell death 1, CD279) a receptor of PDL1 (programmed cell death-1 ligand-1) and PDL2 ligands, IL-1 receptor type I and II (CD121a/CD121b) and OX40 (CD134). However, none of these are unique to Dienestrol Treg cells [1C7, 9C11]. The IL-2 receptor is composed of , , and chains. The active receptor is a trimer composed of chains and its constitutive expression is vital for the success of Treg cells. Interleukin 2 (T-cell development factor) is vital for preserving tolerance and stopping autoimmunity by Foxp3+ cells. Because Tregs usually do not generate IL-2, their proliferation and suppressor function depends upon exogenous IL-2 made by T-effector cells (Body 3). Linking of IL-2 towards the receptor induces tyrosine kinase-dependent STAT5 proteins appearance, elevated transcription of cytokine genes (IL-10, IL-35, TGF-1) and activation from the kinase-dependent MAPK and P13K pathways in Tregs. IL-2 is Ptgs1 certainly nevertheless a double-sword aspect since it stimulates many effector cells such as for example B-cells also, monocytes, mast cells, lymphokine-activated killer cells, organic killer cells, and glioma cells [9]. Open up in another window Body 3 Activation and regulatory function of Treg. Synapse of three cells: Treg lymphocyte, Th responder (effectors) lymphocyte (Teff) and antigen delivering cell (APC) resulting in activation of Tregs. Treg cell getting into apposition with an interacting APCCTeff set through ligation from the TCR in the Treg cell with an MHC course II molecule in the APC. Both APC as well as the Tres cell secrete IL-2, which by binding to CD25 indicated within the Treg cell surface and may induce the Treg cell to proliferate, proliferating Treg by secreting IL-10 and TGF-1 suppress the function of DC and Tres [altered from 5, 50] The transcription element Foxp3 is vital for the development and features of CD4(+)CD25(+) Tregs. Mutations, which cause loss of Foxp3 function, both in mice and males, result in the absence of Tregs and lead to a phenotype with severe autoimmune disorders [34], known as scurfy mice and IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) in males. The important function of FOXP3 was also confirmed by studies showing that ectopic manifestation of Foxp3 in T cells leads to.