Okay, let's tackle this math problem. We're starting with 53922 and subtracting 35901.

Step 1: We'll start by subtracting the digit 1 and the borrow 0 from 2 in column 1 and get 1.
1 is the first digit of our result.

Step 2: We'll start by subtracting the digit 0 and the borrow 0 from 2 in column 2 and get 2.
2 is the next digit of our result.

Step 3: We'll start by subtracting the digit 9 and the borrow 0 from 9 in column 3 and get 0.
0 is the next digit of our result.

Step 4: We'll start by subtracting the digit 5 and the borrow 0 from 3 in column 4 and get -2.
We add -2 to 10 and get 8 as the next digit of the result.

Step 5: We'll start by subtracting the digit 3 and the borrow 1 from 5 in column 5 and get 1.
1 is the next digit of our result.

So, 53922 - 35901 = 18021.