Got it! So, we have 744876 and 99250, and we'll subtract the latter from the former.

Step 1: We'll start by subtracting the digit 0 and the borrow 0 from 6 in column 1 and get 6.
6 is the first digit of our result.

Step 2: We'll start by subtracting the digit 5 and the borrow 0 from 7 in column 2 and get 2.
2 is the next digit of our result.

Step 3: We'll start by subtracting the digit 2 and the borrow 0 from 8 in column 3 and get 6.
6 is the next digit of our result.

Step 4: We'll start by subtracting the digit 9 and the borrow 0 from 4 in column 4 and get -5.
We add -5 to 10 and get 5 as the next digit of the result.

Step 5: We'll start by subtracting the digit 9 and the borrow 1 from 4 in column 5 and get -6.
We add -6 to 10 and get 4 as the next digit of the result.

Step 6: We'll start by subtracting the digit 0 and the borrow 1 from 7 in column 6 and get 6.
6 is the next digit of our result.

So, 744876 - 99250 = 645626.