Located adjacent to the Atlantic Ocean, the Key Colony complex is a gated community of four independently operated condominiums located on Key Biscayne, Florida. The four buildings, Botanica, EmeraldBay, Tidemark, and Oceansound, were constructed in the 1970s and 1980s and are one of the larger complexes on the island. There are about 1,200 units. The complex features a private beach, tennis courts, and swimming pools. There is a small retail center within the complex, as well as a public shopping center, Key Colony Plaza, that is adjacent to the complex.

The complex is notable for its expanse—more than —its unusual architectural design, and for its contribution to the history of development on the island of Key Biscayne—projects that have been the subject of citizen initiatives to limit further development on the island.

Architectural and landscape design

The Key Colony complex has won numerous awards from professional groups for its architectural and landscaping design, which blends its seaside location with tropical flora. Awards include the National Association of Home Builders Grand Award (1980), The Florida Nurserymen and Growers Association (six awards between 1982 and 1983), and two awards from the American Society of Landscape Architects (1982 and 1983).

History

The complex was the brainchild of developer Fritz Scharenberg, who paid to bring out a new water main from the Miami mainland to accommodate the project at a cost of $1.8 million in 1977. For three of the buildings, Scharenberg specified a "pyramid" design, on a 32-degree slope, to maximize privacy between floors. The fourth building, Botanica, was designed to integrate a living garden intertwined among the residential units.

References

External links
 Botanica
 EmeraldBay

Residential condominiums in the United States
Gated communities in Florida


Jerome "Jeremy" McComb (born in Idaho) is an American country music artist and former tour manager for comedian Larry the Cable Guy. In 2008, he signed to Parallel/New Revolution Records and released his debut album My Side of Town that year. This album produced the singles "Wagon Wheel", "This Town Needs a Bar" and "Cold". Although the first two singles did not chart, "Cold" has become his first entry on the Billboard country charts, debuting at No. 58 in November.

Biography
Jeremy McComb was born in Idaho. His father, Bob, was a local musician who played six nights a week and regularly brought him to venues where he performed. McComb made his singing debut at age eight, when his father invited him to join him onstage to sing Willie Nelson's "On the Road Again". Later on, McComb found work as a music director and disc jockey at the radio station KIXZ-FM in Spokane, Washington.  He then befriended comedian Larry the Cable Guy while working at the station, and was hired as the comedian's tour manager in 2004 at age 23.

McComb began working on his music while serving as Larry's manager. While with the comedian, he was introduced to J.P. Williams, the CEO of Parallel Entertainment. He was then sent to a studio in Spartanburg, South Carolina, where he began recording his debut album. Initially, it was to have been released on a division of Warner Bros. Records, but legal difficulties forced Williams to release it on his own label instead. Entitled My Side of Town, it was released on Parallel/New Revolution in June 2008, and was produced by Paul Riddle of the Marshall Tucker Band. The first single from the album, "Wagon Wheel," was originally recorded by Bob Dylan and later by the Old Crow Medicine Show and Darius Rucker. Following it was "This Town Needs a Bar," which was written by Liz Rose and Jimmy Yeary, and was originally featured in the soundtrack to the film Larry the Cable Guy: Health Inspector. The first two singles both failed to chart, although the third single, "Cold", debuted at number 58 on the Billboard country charts in November 2008 and peaked at number 43.

Country Weekly magazine gave My Side of Town three-and-a-half stars out of five, calling it "one of the year's most encouraging [albums]". "Cold" received a favorable review from the country music review site Roughstock, whose critic Matt Bjorke called it "a ballad which details the difficulties that people sometimes have in getting over a relationship…McComb sings about feeling numb, or 'Cold' about the way that the relationship ended."

Following his major label debut McComb independently released an EP titled "Leap and the Net will Appear". Which included the song "Easy as breathing" co-written with Kevin Kadish (Meghan Trainor / Jason Mraz producer & collaborator) The song while never worked as a single picked up AirPlay across the country.

In 2014, McComb bought the Honky-tonk he started his career in with longtime friend Bob Kreaman. "Nashville North" opened October 22, 2014, and is located in Stateline Idaho and hosts national tour acts and has been Voted the No. 1 live music venue in the region 5 years running.

McComb has continued to carve his path releasing in 2017 a Studio album titled "FM" (Pronounced Eff'um) and in 2018 a LIVE Double album featuring masterful story-telling creating an instant connection with song and audience. Jeremy resides in Nashville, TN and still tours 150 + days a year. There is. a new release just announced to be released in 2020.

Discography

Albums

Singles

Music videos

References

External links
Official website

American country singer-songwriters
Living people
Singer-songwriters from Washington (state)
Year of birth missing (living people)


Hindustan Dainik (or just Hindustan) is an Indian Hindi-language daily newspaper. According to WAN-IFRA, it ranked 13th in the world by circulation in 2016 and per the Audit Bureau of Circulations was 6th in India in 2022. Madan Mohan Malaviya launched it in 1936. It is published by Hindustan Media Ventures Limited. Earlier it was part of HT Media Ltd group, which spun off its Hindi business into a separate company named Hindustan Media Ventures Limited in December 2009.

It ranks as the second largest-read daily in the country. Hindustan has 21 editions across the Hindi belt. They are spread across Delhi, Haryana (Faridabad), Bihar (Patna, Muzaffarpur, Gaya, Bhagalpur and Purnea), Jharkhand (Ranchi, Jamshedpur and Dhanbad), Uttar Pradesh (Lucknow, Varanasi, Meerut, Agra, Allahabad, Gorakhpur, Bareilly, Moradabad, Aligarh, and Kanpur) and Uttarakhand (Dehradun, Haridwar, Haldwani). Apart from these, the paper is also available in key towns like Mathura, Saharanpur, Faizabad. The major editions of Hindustan are available online in epaper format.

In Bihar
Hindustan dominates in Bihar with an undisputed readership of about 5 million (as per the IRS 2011, Q4). It commands a massive 73% share of the Hindi readership market of Bihar. On 24 April 2018, Hindustan launched its 5th edition in Purnea. On 13 May 2016, a reporter was shot to death.

In Jharkhand
Hindustan has been the No. 1 newspaper of Jharkhand, ever since readership surveys have been reported for the state.

In Uttar Pradesh

Hindustan is expanding rapidly in the state of Uttar Pradesh, which is the largest Hindi newspaper market, and where it is the fastest growing Hindi daily. Apart from a long-standing presence in Lucknow and Varanasi, Hindustan was launched in Meerut, Agra and Kanpur in 2006.
In 2008, Hindustan launched in the cities of Mathura.
In 2009, Hindustan launched in  Allahabad and Bareilly.
In 2010, Hindustan launched in Gorakhpur as well.
In 2011, Hindustan launched in Aligarh, and in 2012 in Moradabad.

In Uttarakhand

Hindustan has made an entry into Uttarakhand with a printing location in Dehradun, in May 2008. This edition covers key cities in Uttarakhand and West UP (like Dehradun, Hrishikesh, Haridwar, Roorkee and Saharanpur).
In Jan 2009, Hindustan started its edition in Haldwani.It has the highest numbers of readers in Uttarakhand at present.

See also
Print media in India

References

External links

epaper

Daily newspapers published in India
Hindi-language newspapers
Madan Mohan Malaviya
Newspapers published in Bhagalpur
Newspapers published in Delhi
Newspapers published in Gaya, India
Newspapers published in Muzaffarpur
Newspapers published in Patna
Newspapers published in Varanasi
Newspapers published in Aurangabad, Bihar
Newspapers established in 1936
Hindustan Times
1936 establishments in India


The men's 67.5 kg powerlifting event at the 2008 Summer Paralympics was contested on 13 September at the Beihang University Gymnasium in Beijing, China. This event was the fifth-lightest of the men's powerlifting weight classes, limiting competitors to a maximum of  of body mass. Powerlifters were divided into two groups, A and B, with group B beginning their lifts at 13:00 and group A at 13:45.

As with all Paralympic powerlifting events, lifters competed in the bench press. Each athlete was allowed three attempts to bench press as much weight as possible. Athletes attempting to break a record were allowed a fourth attempt. For the attempt to be valid, the competitor must have lowered the weighted bar to his chest, held it motionless for a moment, then pressed the bar upwards until his arms were fully extended. If the competitor failed to meet these requirements or any other rule infraction was committed, the attempt was declared invalid by a team of three referees and the result struck from the record.

Results

Key: PR=Paralympic record; NMR=No marks recorded

References

Men's 067.5 kg


Iowa Highway 202 (Iowa 202) is a short state highway in southern Iowa.  The route begins at the Missouri state line, where it continues as Missouri Route 202, and ends at Iowa Highway 2 north of Moulton.

Route description

Iowa Highway 202 begins in Fabius Township, in Davis County, at the Missouri state line just north of Coatsville, Missouri.  It continues in Missouri as Route 202.  For its first , it runs parallel to a former line of the Norfolk & Western railroad.  Because of its proximity to the abandoned rail line, Iowa 202 follows an unusual path; heading northeast, turning north, and then turning northwest into Appanoose County.  It continues to the northwest for  before going through an ess curve which points Iowa 202 to the north towards Moulton.  North of Moulton, Iowa 202 continues due north for , ending at Iowa Highway 2 in Washington Township.

History
The section from Iowa Highway 2 to Moulton was designated in 1920 as Primary Road No. 71. In the 1926 Iowa highway renumbering, Primary Road No. 71 was renumbered as Iowa Highway 142 to avoid conflict with US 71. In 1938, Iowa 142 extended south to the Missouri state line. Iowa 142 was renumbered Iowa Highway 202 in the 1969 Iowa highway renumbering.  No changes to the route have occurred since its designation.

Major intersections

References

External links

202


The 1994–95 New York Knicks season was the 49th season for the Knicks in the National Basketball Association (NBA). The Knicks entered the season as runner-ups of the 1994 NBA Finals, where they lost to the Houston Rockets in seven games. During the off-season, the Knicks acquired Doug Christie from the Los Angeles Lakers. In the 1994 NBA draft, the team selected small forward Monty Williams out of Notre Dame University with the 24th overall pick, and selected point guard Charlie Ward out of Florida State University with the 26th overall pick. However, Christie only played twelve games, because of an ankle injury, and Ward only played ten games due to a wrist injury. In December, the team released Doc Rivers to free agency; Rivers later signed as a free agent with the San Antonio Spurs. The Knicks had a 12–12 start to the season, but then won 17 of their next 19 games, held a 30–16 record at the All-Star break, and posted a 55–27 record in the Atlantic Division. They finished in second place, two games behind the top-seeded Orlando Magic. By earning the #3 seed in the Eastern Conference, the Knicks qualified for the NBA playoffs for the eighth consecutive season.

Patrick Ewing averaged 23.9 points, 11.0 rebounds and 2.0 blocks per game, finished in fourth place in Most Valuable Player voting, and was selected for the 1995 NBA All-Star Game, while John Starks averaged 15.3 points and 5.1 assists per game, and led the league with 217 three-point field goals, becoming the first player ever to reach up to 200 three-pointers in a single season. In addition, Charles D. Smith provided the team with 12.7 points and 1.3 blocks per game, while Derek Harper averaged 11.5 points and 5.7 assists per game, and sixth man Anthony Mason averaged 9.9 points and 8.4 rebounds per game off the bench, and was named Sixth Man of the Year. Charles Oakley only played just 50 games this season due to a toe injury, averaging 10.1 points and 8.9 rebounds per game, and three-point specialist Hubert Davis contributed 10.0 points per game off the bench.

In the Eastern Conference First Round of the 1995 NBA Playoffs, the Knicks defeated the 6th–seeded Cleveland Cavaliers three games to one, advancing to the Eastern Conference Semi-finals. In the Semi-finals, the Knicks faced off against the 2nd–seeded Indiana Pacers for the third consecutive year; despite the Pacers being the #2 seed in the East, the Knicks had home-court advantage in this series, since they had a better regular-season record than the Pacers. The Pacers defeated the Knicks in Game 1, 107–105, as Reggie Miller scored eight points in the final 18.7 seconds to bring the Pacers back from a six-point deficit. The Pacers gained a 3–1 series edge, before the Knicks won two straight games to force a seventh game at Madison Square Garden. With the Knicks down by two points in the final seconds, Ewing had a chance to send the game to overtime, but missed his driving layup attempt, as the Pacers advanced to the Eastern Conference finals.

Following the season, Pat Riley quit as head coach to take over the coaching job with the Miami Heat, while Greg Anthony was left unprotected in the 1995 NBA Expansion Draft, where he was selected by the Vancouver Grizzlies expansion team, and Anthony Bonner was released to free agency.

NBA draft

Roster

Season standings

Division

Conference

Notes
z – Clinched home court advantage for the entire playoffs
c – Clinched home court advantage for the conference playoffs
y – Clinched division title
x – Clinched playoff spot

Record vs. opponents

Game log

Regular season

|- style="background:#cfc;"
| 1
| November 4
| @ Boston
| W 120–107
| Charles Smith (23)
| Patrick Ewing (13)
| Derek Harper (11)
| Boston Garden14,890
| 1–0
|- style="background:#cfc;"
| 2
| November 8
| L.A. Lakers
| W 117–113
| Patrick Ewing (24)
| Charles Oakley (12)
| Derek Harper (8)
| Madison Square Garden19,763
| 2–0
|- style="background:#cfc;"
| 3
| November 10
| Orlando
| W 101–99
| Patrick Ewing (24)
| Charles Smith (13)
| Derek Harper (9)
| Madison Square Garden19,763
| 3–0
|- style="background:#fcc;"
| 4
| November 12
| @ San Antonio
| L 82–101
| Patrick Ewing (22)
| Charles Oakley (10)
| Greg Anthony (5)
| Alamodome19,710
| 3–1
|- style="background:#fcc;"
| 5
| November 14
| @ Utah
| L 97–110
| John Starks (35)
| Patrick Ewing (7)
| John Starks (8)
| Delta Center18,955
| 3–2
|- style="background:#cfc;"
| 6
| November 16
| @ L.A. Lakers
| W 110–89
| Hubert Davis (27)
| Ewing, Oakley (8)
| Mason, Anthony (7)
| Great Western Forum13,630
| 4–2
|- style="background:#fcc;"
| 7
| November 17
| @ Golden State
| L 100–109
| Derek Harper (21)
| Charles Oakley (14)
| Derek Harper (7)
| Oakland-Alameda County Coliseum Arena15,025
| 4–3
|- style="background:#cfc;"
| 8
| November 19
| Atlanta
| W 92–79
| Charles Smith (24)
| Charles Oakley (15)
| three players tied (5)
| Madison Square Garden19,763
| 5–3
|- style="background:#cfc;"
| 9
| November 21
| San Antonio
| W 92–88
| Charles Oakley (16)
| Oakley, Ewing (7)
| three players tied (5)
| Madison Square Garden19,763
| 6–3
|- style="background:#fcc;"
| 10
| November 26
| Charlotte
| L 82–101
| Patrick Ewing (22)
| Ewing, Oakley (14)
| John Starks (7)
| Madison Square Garden19,763
| 6–4
|- style="background:#cfc;"
| 11
| November 29
| @ Washington
| W 99–91
| Patrick Ewing (20)
| Patrick Ewing (15)
| Derek Harper (6)
| US Airways Arena18,756
| 7–4

|- style="background:#fcc;"
| 12
| December 2
| @ Orlando
| L 100–125
| Patrick Ewing (15)
| Charles Oakley (11)
| John Starks (7)
| Orlando Arena16,010
| 7–5
|- style="background:#cfc;"
| 13
| December 3
| Washington
| W 111–95
| Charles Smith (23)
| Patrick Ewing (10)
| Greg Anthony (8)
| Madison Square Garden19,763
| 8–5
|- style="background:#cfc;"
| 14
| December 5
| @ Philadelphia
| W 101–96 (OT)
| Patrick Ewing (25)
| Charles Oakley (15)
| Harper, Ewing (6)
| CoreStates Spectrum14,212
| 9–5
|- style="background:#cfc;"
| 15
| December 6
| Boston
| W 104–90
| Charles Smith (20)
| Oakley, Mason (12)
| Greg Anthony (10)
| Madison Square Garden19,763
| 10–5
|- style="background:#fcc;"
| 16
| December 9
| @ Atlanta
| L 85–89
| Ewing, Smith (20)
| Charles Oakley (15)
| John Starks (6)
| The Omni14,967
| 10–6
|- style="background:#cfc;"
| 17
| December 10
| Philadelphia
| W 107–103
| Patrick Ewing (28)
| Charles Oakley (16)
| Derek Harper (9)
| Madison Square Garden19,763
| 11–6
|- style="background:#fcc;"
| 18
| December 12
| Miami
| L 111–122
| Patrick Ewing (30)
| Charles Oakley (12)
| John Starks (7)
| Madison Square Garden19,763
| 11–7
|- style="background:#cfc;"
| 19
| December 15
| @ Sacramento
| W 94–84
| Patrick Ewing (27)
| Patrick Ewing (18)
| John Starks (9)
| ARCO Arena17,317
| 12–7
|- style="background:#fcc;"
| 20
| December 16
| @ Phoenix
| L 85–106
| Patrick Ewing (15)
| Patrick Ewing (12)
| Derek Harper (6)
| America West Arena19,023
| 12–8
|- style="background:#fcc;"
| 21
| December 18
| @ Portland
| L 87–111
| Patrick Ewing (24)
| Patrick Ewing (14)
| Derek Harper (6)
| Memorial Coliseum12,888
| 12–9
|- style="background:#fcc;"
| 22
| December 20
| New Jersey
| L 83–85
| Patrick Ewing (22)
| Patrick Ewing (11)
| Hubert Davis (4)
| Madison Square Garden19,763
| 12–10
|- style="background:#fcc;"
| 23
| December 22
| Cleveland
| L 90–93
| Charles Oakley (19)
| Charles Oakley (13)
| Derek Harper (6)
| Madison Square Garden19,763
| 12–11
|- style="background:#fcc;"
| 24
| December 25
| @ Chicago
| L 104–107 (OT)
| Patrick Ewing (30)
| Patrick Ewing (13)
| three players tied (6)
| United Center22,854
| 12–12
|- style="background:#cfc;"
| 25
| December 27
| @ New Jersey
| W 99–91
| John Starks (22)
| Ewing, Mason (8)
| Ewing, M. Williams (5)
| Brendan Byrne Arena20,049
| 13–12
|- style="background:#cfc;"
| 26
| December 28
| Detroit
| W 101–93
| Patrick Ewing (30)
| Anthony Mason (14)
| John Starks (8)
| Madison Square Garden19,763
| 14–12
|- style="background:#cfc;"
| 27
| December 30
| @ Minnesota
| W 90–81
| Patrick Ewing (30)
| Patrick Ewing (12)
| Harper, Starks (7)
| Target Center18,122
| 15–12

|- style="background:#cfc;"
| 28
| January 4
| Atlanta
| W 89–80
| Patrick Ewing (21)
| Patrick Ewing (12)
| Ewing, Harper (4)
| Madison Square Garden19,763
| 16–12
|- style="background:#cfc;"
| 29
| January 6
| @ Cleveland
| W 103–93
| John Starks (23)
| Patrick Ewing (11)
| Derek Harper (7)
| Gund Arena20,562
| 17–12
|- style="background:#cfc;"
| 30
| January 8
| Minnesota
| W 102–87
| Ewing, Davis (22)
| Ewing, Mason (9)
| Derek Harper (8)
| Madison Square Garden19,763
| 18–12
|- style="background:#cfc;"
| 31
| January 10
| Indiana
| W 117–105
| John Starks (22)
| Patrick Ewing (9)
| Derek Harper (13)
| Madison Square Garden19,763
| 19–12
|- style="background:#cfc;"
| 32
| January 13
| @ Milwaukee
| W 91–88
| Patrick Ewing (24)
| Patrick Ewing (14)
| Derek Harper (7)
| Bradley Center17,909
| 20–12
|- style="background:#fcc;"
| 33
| January 14
| Utah
| L 81–86
| John Starks (22)
| Patrick Ewing (14)
| Derek Harper (6)
| Madison Square Garden19,763
| 20–13
|- style="background:#cfc;"
| 34
| January 16
| New Jersey
| W 107–90
| Patrick Ewing (32)
| Patrick Ewing (15)
| John Starks (9)
| Madison Square Garden19,763
| 21–13
|- style="background:#cfc;"
| 35
| January 19, 19958:00p.m. EST
| @ Houston
| W 93–77
| Starks (22)
| Ewing (18)
| Starks (7)
| The Summit16,611
| 22–13
|- style="background:#cfc;"
| 36
| January 20
| @ Dallas
| W 106–93
| Patrick Ewing (36)
| Patrick Ewing (12)
| Derek Harper (11)
| Reunion Arena17,502
| 23–13
|- style="background:#cfc;"
| 37
| January 22
| @ Miami
| W 104–95
| John Starks (26)
| Patrick Ewing (15)
| Derek Harper (9)
| Miami Arena15,200
| 24–13
|- style="background:#cfc;"
| 38
| January 24
| Portland
| W 105–99
| John Starks (26)
| Anthony Mason (15)
| Mason, Ewing (5)
| Madison Square Garden19,763
| 25–13
|- style="background:#cfc;"
| 39
| January 26
| L.A. Clippers
| W 87–74
| Patrick Ewing (21)
| Anthony Mason (13)
| Derek Harper (5)
| Madison Square Garden19,763
| 26–13
|- style="background:#fcc;"
| 40
| January 27
| @ Charlotte
| L 90–105
| John Starks (26)
| Anthony Mason (11)
| Derek Harper (6)
| Charlotte Coliseum23,698
| 26–14
|- style="background:#cfc;"
| 41
| January 29
| Phoenix
| W 107–88
| Patrick Ewing (35)
| Anthony Mason (19)
| John Starks (9)
| Madison Square Garden19,763
| 27–14
|- style="background:#cfc;"
| 42
| January 31
| Golden State
| W 90–87
| Derek Harper (26)
| Patrick Ewing (14)
| John Starks (8)
| Madison Square Garden19,763
| 28–14

|- style="background:#cfc;"
| 43
| February 3
| @ Philadelphia
| W 106–86
| Patrick Ewing (30)
| Patrick Ewing (15)
| Derek Harper (7)
| CoreStates Spectrum18,168
| 29–14
|- style="background:#fcc;"
| 44
| February 5
| @ Orlando
| L 100–103 (OT)
| Patrick Ewing (38)
| Patrick Ewing (13)
| Harper, Starks (7)
| Orlando Arena16,010
| 29–15
|- style="background:#fcc;"
| 45
| February 7
| Milwaukee
| L 87–95
| Ewing, Starks (23)
| Patrick Ewing (17)
| Derek Harper (7)
| Madison Square Garden19,763
| 29–16
|- style="background:#cfc;"
| 46
| February 8
| @ Indiana
| W 96–77
| Ewing, Starks (24)
| Patrick Ewing (22)
| Derek Harper (6)
| Market Square Arena16,677
| 30–16
|- style="text-align:center;"
| colspan="9" style="background:#bbcaff;"|All-Star Break
|- style="background:#fcc;"
| 47
| February 14
| @ Detroit
| L 94–106
| Patrick Ewing (24)
| Patrick Ewing (15)
| John Starks (7)
| The Palace of Auburn Hills15,513
| 30–17
|- style="background:#cfc;"
| 48
| February 16
| @ Miami
| W 96–87
| Ewing, Mason (22)
| Anthony Mason (14)
| Mason, Starks (5)
| Miami Arena15,200
| 31–17
|- style="background:#cfc;"
| 49
| February 17
| Miami
| W 100–91
| Hubert Davis (21)
| Anthony Mason (11)
| Harper, Anthony (5)
| Madison Square Garden19,763
| 32–17
|- style="background:#cfc;"
| 50
| February 19, 19951:00p.m. EST
| Houston
| W 122–117
| Ewing (31)
| Mason (10)
| Harper (9)
| Madison Square Garden19,763
| 33–17
|- style="background:#fcc;"
| 51
| February 21
| Cleveland
| L 91–99
| Patrick Ewing (35)
| Patrick Ewing (9)
| Starks, Harper (7)
| Madison Square Garden19,763
| 33–18
|- style="background:#cfc;"
| 52
| February 23
| Sacramento
| W 103–90
| Patrick Ewing (38)
| Anthony Mason (12)
| Derek Harper (9)
| Madison Square Garden19,763
| 34–18
|- style="background:#cfc;"
| 53
| February 26
| Philadelphia
| W 104–99
| Patrick Ewing (32)
| Patrick Ewing (18)
| Derek Harper (6)
| Madison Square Garden19,763
| 35–18
|- style="background:#fcc;"
| 54
| February 28
| @ Orlando
| L 106–118
| Patrick Ewing (32)
| Patrick Ewing (15)
| Starks, Harper (6)
| Orlando Arena16,010
| 35–19

|- style="background:#cfc;"
| 55
| March 2
| Chicago
| W 93–89
| Anthony Mason (26)
| Anthony Mason (12)
| Anthony Mason (7)
| Madison Square Garden19,763
| 36–19
|- style="background:#cfc;"
| 56
| March 4
| @ Cleveland
| W 89–76
| John Starks (29)
| Anthony Mason (14)
| Starks, Harper (6)
| Gund Arena20,562
| 37–19
|- style="background:#cfc;"
| 57
| March 7
| Boston
| W 115–110
| Patrick Ewing (46)
| Patrick Ewing (12)
| Derek Harper (10)
| Madison Square Garden19,763
| 38–19
|- style="background:#cfc;"
| 58
| March 8
| @ Boston
| W 108–100
| Hubert Davis (22)
| Anthony Mason (12)
| Anthony Mason (7)
| Boston Garden14,890
| 39–19
|- style="background:#fcc;"
| 59
| March 10
| @ Atlanta
| L 81–108
| John Starks (17)
| Patrick Ewing (10)
| John Starks (5)
| Omni Coliseum14,596
| 39–20
|- style="background:#fcc;"
| 60
| March 11
| Seattle
| L 84–96
| Patrick Ewing (34)
| Ewing, Oakley (10)
| John Starks (8)
| Madison Square Garden19,763
| 39–21
|- style="background:#cfc;"
| 61
| March 14
| Denver
| W 94–74
| Patrick Ewing (21)
| Charles Oakley (17)
| Derek Harper (5)
| Madison Square Garden19,763
| 40–21
|- style="background:#cfc;"
| 62
| March 17
| @ Washington
| W 89–81
| Patrick Ewing (36)
| Charles Oakley (11)
| John Starks (8)
| US Airways Arena18,756
| 41–21
|- style="background:#cfc;"
| 63
| March 18
| New Jersey
| W 92–91 (OT)
| John Starks (25)
| Patrick Ewing (14)
| Derek Harper (7)
| Madison Square Garden19,763
| 42–21
|- style="background:#fcc;"
| 64
| March 21
| Charlotte
| L 69–78
| Patrick Ewing (35)
| Patrick Ewing (18)
| Derek Harper (9)
| Madison Square Garden19,763
| 42–22
|- style="background:#cfc;"
| 65
| March 23
| @ Denver
| W 104–101
| Patrick Ewing (22)
| Ewing, Smith (8)
| John Starks (9)
| McNichols Sports Arena17,171
| 43–22
|- style="background:#cfc;"
| 66
| March 25
| @ L.A. Clippers
| W 94–86
| Patrick Ewing (27)
| Patrick Ewing (8)
| Derek Harper (6)
| Los Angeles Memorial Sports Arena16,021
| 44–22
|- style="background:#fcc;"
| 67
| March 26
| @ Seattle
| L 93–82
| Patrick Ewing (27)
| Anthony Mason (10)
| John Starks (5)
| Tacoma Dome18,056
| 44–23
|- style="background:#fcc;"
| 68
| March 28
| Chicago
| L 111–113
| Patrick Ewing (36)
| Charles Oakley (8)
| Derek Harper (7)
| Madison Square Garden19,763
| 44–24
|- style="background:#cfc;"
| 69
| March 29
| @ Detroit
| W 107–97
| Patrick Ewing (28)
| Charles Oakley (9)
| Derek Harper (7)
| The Palace of Auburn Hills17,067
| 45–24
|- style="background:#cfc;"
| 70
| March 31
| Dallas
| W 101–90
| Patrick Ewing (18)
| Anthony Bonner (9)
| Harper, Anthony (6)
| Madison Square Garden19,763
| 46–24

|- style="background:#cfc;"
| 71
| April 2
| @ New Jersey
| W 94–85
| John Starks (26)
| Charles Oakley (12)
| Anthony Mason (6)
| Brendan Byrne Arena20,049
| 47–24
|- style="background:#fcc;"
| 72
| April 4
| Indiana
| L 90–94
| Patrick Ewing (28)
| Anthony Mason (14)
| Derek Harper (12)
| Madison Square Garden19,763
| 47–25
|- style="background:#cfc;"
| 73
| April 5
| @ Milwaukee
| W 114–94
| Patrick Ewing (34)
| Patrick Ewing (18)
| John Starks (6)
| Bradley Center14,679
| 48–25
|- style="background:#cfc;"
| 74
| April 8
| Detroit
| W 113–96
| Patrick Ewing (19)
| Anthony Mason (9)
| John Starks (8)
| Madison Square Garden19,763
| 49–25
|- style="background:#cfc;"
| 75
| April 11
| Miami
| W 112–99
| Patrick Ewing (31)
| Ewing, Mason (12)
| John Starks (9)
| Madison Square Garden19,763
| 50–25
|- style="background:#cfc;"
| 76
| April 13
| Washington
| W 110–100
| Patrick Ewing (25)
| Patrick Ewing (8)
| Greg Anthony (7)
| Madison Square Garden19,763
| 51–25
|- style="background:#cfc;"
| 77
| April 14
| @ Indiana
| W 88–84
| Patrick Ewing (30)
| Patrick Ewing (12)
| John Starks (7)
| Market Square Arena16,702
| 52–25
|- style="background:#fcc;"
| 78
| April 16
| @ Chicago
| L 90–111
| Charles Smith (22)
| Anthony Mason (13)
| Derek Harper (4)
| United Center23,889
| 52–26
|- style="background:#fcc;"
| 79
| April 17
| Milwaukee
| L 93–99
| Anthony Mason (17)
| Patrick Ewing (13)
| Anthony Mason (7)
| Madison Square Garden19,763
| 52–27
|- style="background:#cfc;"
| 80
| April 20
| @ Charlotte
| W 91–86
| John Starks (18)
| Anthony Mason (9)
| John Starks (7)
| Charlotte Coliseum23,698
| 53–27
|- style="background:#cfc;"
| 81
| April 21
| @ Boston
| W 99–92
| Hubert Davis (20)
| Charles Oakley (16)
| Greg Anthony (8)
| Boston Garden14,890
| 54–27
|- style="background:#cfc;"
| 82
| April 23
| Orlando
| W 113–99
| Charles Smith (29)
| Anthony Mason (12)
| Mason, Anthony (6)
| Madison Square Garden19,763
| 55–27

Playoffs

|- style="background:#cfc;"
| 1
| April 27
| Cleveland
| W 103–79
| Patrick Ewing (21)
| Charles Oakley (11)
| John Starks (7)
| Madison Square Garden19,763
| 1–0
|- style="background:#fcc;"
| 2
| April 29
| Cleveland
| L 84–90
| Ewing, Starks (21)
| Patrick Ewing (12)
| Charles Oakley (5)
| Madison Square Garden19,763
| 1–1
|- style="background:#cfc;"
| 3
| May 1
| @ Cleveland
| W 83–81
| Patrick Ewing (23)
| Patrick Ewing (10)
| Derek Harper (5)
| Gund Arena19,352
| 2–1
|- style="background:#cfc;"
| 4
| May 4
| @ Cleveland
| W 93–80
| Derek Harper (30)
| Patrick Ewing (13)
| Charles Oakley (8)
| Gund Arena18,575
| 3–1

|- style="background:#fcc;"
| 1
| May 7
| Indiana
| L 105–107
| John Starks (21)
| Oakley, Ewing (10)
| John Starks (7)
| Madison Square Garden19,763
| 0–1
|- style="background:#cfc;"
| 2
| May 9
| Indiana
| W 96–77
| Derek Harper (24)
| Anthony Mason (8)
| Derek Harper (8)
| Madison Square Garden19,763
| 1–1
|- style="background:#fcc;"
| 3
| May 11
| @ Indiana
| L 95–97
| Oakley, Starks (23)
| Charles Oakley (7)
| John Starks (9)
| Market Square Arena16,675
| 1–2
|- style="background:#fcc;"
| 4
| May 13
| @ Indiana
| L 84–98
| Patrick Ewing (25)
| Charles Oakley (10)
| Derek Harper (10)
| Market Square Arena16,678
| 1–3
|- style="background:#cfc;"
| 5
| May 17
| Indiana
| W 96–95
| Patrick Ewing (19)
| Charles Oakley (13)
| John Starks (7)
| Madison Square Garden19,763
| 2–3
|- style="background:#cfc;"
| 6
| May 19
| @ Indiana
| W 92–82
| Patrick Ewing (25)
| Patrick Ewing (15)
| Derek Harper (7)
| Market Square Arena16,679
| 3–3
|- style="background:#fcc;"
| 7
| May 21
| Indiana
| L 95–97
| Patrick Ewing (29)
| Patrick Ewing (14)
| Harper, Oakley (6)
| Madison Square Garden19,763
| 3–4

Awards and honors
Patrick Ewing was named Player of the Week for games played January 15 through January 22.
Patrick Ewing was named Player of the Month for January.
Patrick Ewing was selected as a reserve for the Eastern Conference in the All-Star Game. It was his ninth All-Star selection.
Anthony Mason received the NBA Sixth Man of the Year Award.
John Starks led the league in three-point field goals with 217.
John Starks led the league in three-point field goal attempts with 611.

Player stats

Regular season

Playoffs

Source:

Transactions
The Knicks were involved in the following transactions during the 1994–95 season.

Trades

Free agents

Additions

Subtractions

Source:

Notes

References

External links
1994–95 New York Knicks Statistics

New York Knicks seasons
New York Knicks
New York Knicks
New York Knick
1990s in Manhattan
Madison Square Garden


In the mathematical field of graph theory, Tietze's graph is an undirected cubic graph with 12 vertices and 18 edges.
It is named after Heinrich Franz Friedrich Tietze, who showed in 1910 that the Möbius strip can be subdivided into six regions that all touch each other – three along the boundary of the strip and three along its center line – and therefore that graphs that are embedded onto the Möbius strip may require six colors. The boundary segments of the regions of Tietze's subdivision (including the segments along the boundary of the Möbius strip itself) form an embedding of Tietze's graph.

Relation to Petersen graph
Tietze's graph may be formed from the Petersen graph by replacing one of its vertices with a triangle.
Like the Tietze graph, the Petersen graph forms the boundary of six mutually touching regions, but on the projective plane rather than on the Möbius strip. If one cuts a hole from this subdivision of the projective plane, surrounding a single vertex, the surrounded vertex is replaced by a triangle of region boundaries around the hole, giving the previously described construction of the Tietze graph.

Hamiltonicity
Both Tietze's graph and the Petersen graph are maximally nonhamiltonian: they have no Hamiltonian cycle, but any two non-adjacent vertices can be connected by a Hamiltonian path. Tietze's graph and the Petersen graph are the only 2-vertex-connected cubic non-Hamiltonian graphs with 12 or fewer vertices.

Unlike the Petersen graph, Tietze's graph is not hypohamiltonian: removing one of its three triangle vertices forms a smaller graph that remains non-Hamiltonian.

Edge coloring and perfect matchings
Edge coloring Tietze's graph requires four colors; that is, its chromatic index is 4. Equivalently, the edges of Tietze's graph can be partitioned into four matchings, but no fewer.

Tietze's graph matches part of the definition of a snark: it is a cubic bridgeless graph that is not 3-edge-colorable. However, most authors restrict snarks to graphs without 3-cycles, so Tietze's graph is not generally considered to be a snark. Nevertheless, it is isomorphic to the graph J3, part of an infinite family of flower snarks introduced by R. Isaacs in 1975.

Unlike the Petersen graph, the Tietze graph can be covered by four perfect matchings. This property plays a key role in a proof that testing whether a graph can be covered by four perfect matchings is NP-complete.

Additional properties
Tietze's graph has chromatic number 3, chromatic index 4, girth 3 and diameter 3.  The independence number is 5. Its automorphism group has order 12, and is isomorphic to the dihedral group D6, the group of symmetries of a hexagon, including both rotations and reflections.  This group has two orbits of size 3 and one of size 6 on vertices, and thus this graph is not vertex-transitive.

Gallery

See also
Dürer graph and Franklin graph, two other 12-vertex cubic graphs

Notes

Individual graphs
Regular graphs


The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume II: The Kingdom on the Waves (2008) is a historical novel written for young adults by M. T. Anderson and published by Candlewick in 2008, and a sequel to Volume I: The Pox Party (2006). The American Library Association named it a Printz Honor Book, one of four runners-up for the annual Michael L. Printz Award recognizing literary excellence in books for young adults.

Characters
 Octavian: A boy of African descent, and technically a slave in the Gitney household, although he is brought up in luxury for much of his childhood. He is very skilled at the violin, quiet, and is fluent in Latin, French, and Greek.
 Mr. Gitney (03-01): The head of the Novanglian College of Lucidity, a group of scientists and philosophers, and the owner of Octavian.
 Dr. Trefusis (09-01): Octavian's classics teacher.
 Bono: A slave in the Gitney house whose full name is "Pro Bono". Bono and Octavian become good friends, until Bono is sold South, at which point he leaves a house key for Octavian in case Octavian ever wants to escape. After Bono is sent south we learn that he has escaped his new master.

Analysis
A School Library Journal article states that when viewed within the framework of Gothic fiction, the Novanglian College of Lucidity can be equated with the "Gothic Castle" and the professors with "monsters".

See also
 M. T. Anderson
 American Revolution
 Boston, Massachusetts

References

 "A War Within a War for Freedom". Review of The Kingdom on the Waves by M. T. Anderson. Gavin J. Grant. Los Angeles Times, November 1, 2008.

2008 American novels
American historical novels
American young adult novels
Candlewick Press books
Sequel novels


The Supervillains is a five-piece reggae, ska/punk band from St. Cloud, Florida. The band has released nine studio albums.

History

Formation and Self-Titled EP (1996–2000)
During the summer of 1996, Floridian high school friends Scott "Skart" Suldo on guitar/vocals and Dominic "Dom" Maresco on drums/vocals started playing together under the name 'The Supervillains'. The duo released their self-titled debut album EP in 2000.

Horseshoes and Handgrenades and Jahmerica (2002–2004)
In 2002, the band released their second self-produced studio album, Horseshoes and Handgrenades with new member Jonathan "Smally" Cestero on saxophone.

Then, they released their third album, Jahmerica in 2004 on Prairie Dawgin' Records, paying homage to their reggae roots.

With members coming and going over the years, including a horn section ("Smally" on sax and new member Ricardo "Cardo" San Jose on trumpet being the longer-mainstays), the band is self-described "Florida-bred swamp reggae rockers".

Grow Yer Own and Massive (2006–2008)

After touring with Pepper, they were signed to their label, LAW Records and released their fourth album Grow Yer Own in 2006.

After the addition of bassist Dan Grundorf, the band released their fifth album, Massive in 2008.

Postcards From Paradise and Robots EP (2011–2012)

On February 8, 2011, they released their sixth album, Postcards From Paradise on their own label, Rah Rah Rah Records. This was the first time the band worked with producer Brett Hestla who mixed and engineered the album, as well as provided backing vocals on the single "Free".

They released their first EP (and seventh album), titled Robots on May 1, 2012, featuring songs about robots in different settings (i.e. Limbo, Purgatory or Hell).

Volume 8 (2013)
The band is currently signed to LAW Records and continue to tour and perform with other groups from the label. The Supervillains were formerly signed to Rah Rah Rah Records, with whom they released their eighth studio album Volume 8 on April 9, 2013. The album featured many special guests including: Leilani Wolfgramm, Charlie Bender of The Spitvalves, Blak, Antonee First Class, and saxophonist Jeff Richie of The Toasters, as well as Brett Hestla who once again produced the album.

Nice Things (2017)
Wanting to concentrate on programming and production, Dan Grundorf permanently handed over the reins to former Abandon the Midwest bassist B.J. Hall, the band's long-time stage/guitar-tech and tour bus driver, as well as being signed to the band's own label, Rah Rah Rah Records. With Hall on board, the band released their ninth studio album Nice Things in 2017, back on LAW Records.

The Supervillains was one of many reggae and punk bands that was featured on The House That Bradley Built, a tribute to Sublime and the Bradley Nowell family's non-profit "Bradley's House", which was released on January 15, 2021. The band covered Sublime's song "What Happened", listed on disc 2 of the deluxe edition of the album.

Drones EP (2021)
On November 26, 2021, The Supervillains released their second EP, Drones, a direct follow-up to their Robots EP from 2012. It was recorded in a barn during the lock down of the COVID-19 epidemic. Drummer Dom Moresco summed up the EP in one sentence, "The Drones EP is like a 25-minute-long movie for your ears." He added, "It's meant to be listened to in its entirety, you'll laugh; you'll cry, and you'll wanna listen to it again."

Also, in a two-month anticipation of the Drones EP, the band released a stand-alone single titled, "Daisy" in ode to the Vaudeville-era song the operating system "HAL" rebooted to in Stanley Kubrick's film, 2001: A Space Odyssey.

Tours
The Supervillains have been a supporting band on tour with reggae, punk, ska bands: Pepper, Slightly Stoopid, Dirty Heads, Fishbone, NOFX, Streetlight Manifesto, Mu330, Inner Circle, Authority Zero, the Expendables, the Mad Caddies, Less Than Jake, The English Beat, and Catch 22.

Musical influences
In a 2016 interview about who influences them on writing original music, Dom answers, "We group up, listening to a lot of music ranging from grunge to punk, hip-hop, and reggae. We have been influenced by The Suicide Machines, Sublime, Operation Ivy, The Skatalites, The Toasters, and The Beatles."

Collaborations
They have collaborated with artists such as Jack Ruby Jr. and Jeff Richey of The Toasters, Kyle MacDonald of Slightly Stoopid, and Kris Bentley formerly of Inner Circle.

Lineup

Current members
Scott "Skart" Suldo – guitars, lead vocals (1996–present)
Dominic "Dom" Maresco – drums, backing vocals (1996–present)
Tom "T-Rex" Moulton – keyboards (2012–present)
B.J. Hall – bass (2017–present)
Joshua Senften – saxophone (2017–present)

Past members
Jonathan "Smally" Cestero – tenor saxophone, flute (2002–2013)
Dan Grundorf – bass, sampler, programming (2008–2017)
Ricardo "Cardo" San Jose – trumpet (2006–2009)
Nathan Anderson – saxophone (2011)

Discography

Studio albums

Extended play (EPs)

Singles

References

External links
Official Site
The Supervillains on MySpace
 The Supervillains on Facebook
Rah Rah Rah Records
LAW Records
The Supervillains Interview on thepier.org

1998 establishments in Florida
American musical quintets
American ska musical groups
American reggae musical groups
Musical groups from Orlando, Florida
Musical groups established in 1998
People from St. Cloud, Florida
Reggae rock groups


Aleksandr Dmitriyevich Loktionov (; ) – 28 October 1941) was a Soviet general.

In 1923 he was given command of the 2nd Infantry Division in Belarus, and the next year he became a member of the Minsk City Council. In 1925 he became a member of the Central Executive Committee of the Byelorussian Soviet Socialist Republic and the Central Party Committee before continuing his education at the Frunze Military Academy in 1927. At the end of 1930 he became the commanding officer and commissar of the 4th Rifle Corps. From 1933 to 1937, he was assistant commander of the Byelorussian and subsequently Kharkov Air Force Military Districts.

From 1937 to 1939, he served as commander-in-chief of the Soviet Air Force. In July 1940, after the Soviet occupation of the Baltic states, Loktionov was appointed commander of the Special Baltic Military District. In June 1941, he was arrested on fabricated charges of participation in an anti-Soviet conspiracy. Under interrogation, he was brutally beaten by infamous NKVD interrogators Boris Rodos and Lev Shvartsman, and lost consciousness several times from the torture. He was later put in a "confrontation" with Kirill Meretskov; the NKVD used Loktionov's bloodied appearance to intimidate Meretskov. After the German Invasion of the Soviet Union, he was moved from a local NKVD prison to the Kuybyshev prison, where he was shot without trial on 28 October along with many others on the personal orders of Lavrentiy Beria. He was posthumously rehabilitated in 1955.

See also

 1941 Red Army Purge

References

1893 births
1941 deaths
Executed people from Kursk Oblast
Soviet colonel generals
Candidates of the Central Committee of the 18th Congress of the All-Union Communist Party (Bolsheviks)
Executed Soviet people from Russia
Russian people executed by the Soviet Union
Executed Russian people
Deaths by firearm in the Soviet Union
Occupation of the Baltic states
Executed military leaders
Recipients of the Order of the Red Banner


Jerry Gordon is an American radio broadcaster. He is the afternoon news anchor on KNIH in Las Vegas, Nevada.  His voice-over work included 10 years as "the voice of Disney." He previously worked at KSFO in San Francisco.
He is originally from New York City, New York. He was born in Norwich, Connecticut.

Notes

American radio news anchors
Radio personalities from the Las Vegas Valley
Radio personalities from San Francisco
Living people
Year of birth missing (living people)


Reduced to Ashes may refer to:
Reduced to Ashes (Deeds of Flesh album), released in 2003
Reduced to Ashes (Memorain album), released in 2006
Reduced to Ashes: The Insurgency and Human Rights in Punjab, 2003 book


Branford High School is the only public high school in Branford, Florida, United States.

References

External links

 Suwannee County School District, Suwannee County, FL

Schools in Suwannee County, Florida
Public high schools in Florida


Frank Theatre Company, formerly known as Screaming Weenie, is a professional theatre company in Vancouver, British Columbia, Canada committed to the production, promotion and development of queer and sex positive arts and artists.  The company defines 'queer' as individuals and groups outside of sexual and gender norms. Frank Theatre Company is a non-profit society and a federally registered charity.

Early years

Incorporated in 2003 with co-founder and original artistic director Ilena Lee Cramer at the helm,  the company established itself by staging new plays and creative collaborations at Vancouver night clubs. While Screaming Weenie was a self-described 'queer company', a  descriptive quote from Cramer from the on-line magazine Word Play in 2004 reads, "The Weenies do theatre for a wide audience - I'm interested in reaching those who are disenfranchised by art".

Original creations by Screaming Weenie in this period included The Bacchae - an electronic opera, The Sound of Disco and The Wizard of Glam. The company also produced the plays Belly by Dawn Wendy McLeod, Clue in the Fast Lane by Ann Marie MacDonald and Beverley Cooper, The Well of Horniness by Holly Hughes and Lounge by Tanya Marquardt.

Second stage

Seán Cummings was hired as the company's artistic director in 2008. Cummings had previously worked with other theatre companies in Vancouver on seminal queer-themed works as Martin Sherman's Bent, Brad Fraser's Poor Super Man and Richard Greenberg's Take Me Out. Under Cummings' leadership, the company produced the highly acclaimed world premiere of C. E. Gatchalian's Falling In Time, which was nominated for the 2013 Lambda Literary Award. Cummings left the company in 2012, and was succeeded by Gatchalian.

In late 2017, after a series of significant financial and operational challenges, Gatchalian left the company, and was succeeded by current Artistic Director Fay Nass.

References

Theatre companies in British Columbia
Theatre in Vancouver
LGBT theatre in Canada
LGBT theatre companies


The men's 75 kg powerlifting event at the 2008 Summer Paralympics was contested on 14 September at the Beihang University Gymnasium in Beijing, China. This event was the fifth-heaviest of the men's powerlifting weight classes, limiting competitors to a maximum of  of body mass. Powerlifters were divided into two groups, A and B, with group B beginning their lifts at 16:30 and group A at 17:15.

As with all Paralympic powerlifting events, lifters competed in the bench press. Each athlete was allowed three attempts to bench press as much weight as possible. Athletes attempting to break a record were allowed a fourth attempt. For the attempt to be valid, the competitor must have lowered the weighted bar to his chest, held it motionless for a moment, then pressed the bar upwards until his arms were fully extended. If the competitor failed to meet these requirements or any other rule infraction was committed, the attempt was declared invalid by a team of three referees and the result struck from the record.

Results

References

Men's 075 kg


Đuro Ostojić (born 17 February 1976) is a Montenegrin retired professional basketball executive and former player who is a general manager for Studentski centar. At , he played the center position.

Professional career
In his professional career, Ostojić has played with Mornar, Budućnost Podgorica, Lovćen, Partizan, Breogán, Beşiktaş Cola Turka, PAOK, Gravelines-Dunkerque and Panellinios.

National team
Ostojić represented Serbia and Montenegro at the EuroBasket 2003 and the 2004 Summer Olympics. He was also a member of the Montenegrin national team.

External links
 Đuro Ostojić at acb.com
 Đuro Ostojić at euroleague.net

1976 births
Living people
BCM Gravelines players
Beşiktaş men's basketball players
CB Breogán players
Centers (basketball)
KK Budućnost players
KK Lovćen players
KK Mornar Bar players
KK Partizan players
Liga ACB players
Serbia and Montenegro men's basketball players
Montenegrin men's basketball players
Olympic basketball players for Serbia and Montenegro
P.A.O.K. BC players
Panellinios B.C. players
Sportspeople from Bar, Montenegro
Basketball players at the 2004 Summer Olympics
Montenegrin expatriate basketball people in Greece
Montenegrin expatriate basketball people in Turkey
Montenegrin expatriate basketball people in France
Montenegrin expatriate basketball people in Spain
Serbia and Montenegro expatriate sportspeople in Spain
Mediterranean Games medalists in basketball
Mediterranean Games bronze medalists for Serbia and Montenegro
Competitors at the 1997 Mediterranean Games


Robert Bruce Ricketts (April 29, 1839 – November 13, 1918) distinguished himself as an artillery officer in the American Civil War. He is best known for his battery's defense against a Confederate attack on Cemetery Hill on the second day of the Battle of Gettysburg on July 2, 1863.

Early life
Elijah Ricketts was a merchant and farmer in Orangeville in Columbia County, Pennsylvania.  He married Margaret Leigh Lockart (1810–1891) in 1830. Robert Bruce Ricketts was the fifth of nine children of this union, born on April 29, 1839.  An older brother, William Wallace Ricketts (b. 1837), attended the United States Military Academy; but he died in 1862.  Bruce Ricketts was educated at the Wyoming Seminary near Wilkes-Barre.  When the war broke out, he was studying law and considering the possibility of a university education.

Early Civil War
The First Pennsylvania Light Artillery (otherwise known as the 43rd Regiment Pennsylvania Volunteers) was organized in 1861.  The regiment left for Washington, D.C. in August of that year.  Battery F was formed under Capt. Ezra W. Matthews.  Bruce Ricketts joined the service on July 8, as a private of that year, and he was commissioned as first lieutenant in that battery about a month later.  The regiment was split up, with individual batteries serving with different divisions of the Army of the Potomac.  Battery F first saw combat at the Battle of Dranesville on December 20, 1861.  Ricketts' section had one gun disabled in that action.  Later the section served in the defense of Hancock, Maryland, against a foray by Stonewall Jackson.

Battery F served in the Army of Virginia in the corps of Major General Irwin McDowell, joining it on March 21, 1862, at Warrenton, Virginia.  In that context it was involved, under Ricketts' leadership, in a reconnaissance expedition to Rappahannock Station, Virginia, that left on April 7, of that year.  This force advanced and then withdrew, having accomplished its information-gathering purpose.  Thereafter the battery was involved in the campaign culminating in the Second Battle of Bull Run.  Battery F was seriously engaged in the Battle of Cedar Mountain on August 8, helping McDowell cover the retreat of the corps of Major General Nathaniel Banks.  The battery helped defend Henry House Hill at Second Bull Run, and it was present at the Battle of Chantilly though not engaged.  It also participated in the "artillery hell" of the Battle of Antietam.  Lt. Ricketts missed most of these actions while serving on recruiting duty.  He returned to the Army of the Potomac on September 23, 1862.

Ricketts commanded Battery F, First Pennsylvania Light Artillery from then on until the summer of 1864.  Capt. Matthews went down ill and did not return to battery command.  Ricketts was engaged with his guns at the Battle of Fredericksburg, serving with second division I Corps under Major General John F. Reynolds.  When Capt. Matthews was promoted to the rank of major, Ricketts became a captain on March 14, 1863.  At the Battle of Chancellorsville Ricketts' battery was with Major General Abner Doubleday's third division I Corps.

Gettysburg
Ricketts' battery was – beginning on May 13, 1863 – in the third volunteer brigade of the Reserve Artillery under Capt. James F. Huntington.  Battery G, First Pennsylvania Light Artillery, was attached to Ricketts' battery a few weeks before the Battle of Gettysburg, on June 1, 1863.  This merger was resented until gunners from Battery G were permitted to form a section of the consolidated battery.  This merger took place while the army was marching north in pursuit of the Army of Northern Virginia, beginning on May 15.

Ricketts' battery arrived in Gettysburg on the Taneytown Road on the morning of July 2, 1863, and replaced Capt. James H. Cooper's Battery B, First Pennsylvania Light Artillery, on East Cemetery Hill about 4:00 PM.  It was exposed to enfilade fire from Benner's Hill and Seminary Ridge.  Around nightfall, two Confederate brigades from the division of Major General Jubal Early attacked the hill.  It broke the thin Union front line at the foot of the hill in two places.  In other places they were repelled.  Some Confederates reached the top of the hill, and one group attacked the left of Ricketts' battery, trying to spike the guns.  The fight for the guns became hand to hand, but the Confederates were unable to capture the whole battery.  Eventually Union reinforcements from the II Corps brigade of Col. Samuel S. Carroll drove the Confederates down hill.  A monument to the battery stands in the general location of their fight.

After the battle, Ricketts criticized Adelbert Ames' division of XI Corps, although he probably could not see what was going on down there at the foot of the hill.   He thought they fled unnecessarily.  Ricketts' account of the action makes it look as if his battery stood alone for an extended time.  However, a less colorful account by a modern historian shows that some of  the XI Corps troops had rallied and stood fast atop Cemetery Hill even before reinforcements from Col. Carroll's brigade of II Corps came up behind Ricketts' position.

After Gettysburg
After Gettysburg, Ricketts' battery F was transferred to the artillery brigade of II Corps in time for the Bristoe Campaign.  At the Second Battle of Auburn on October 14, 1863, the battery helped first division II Corps cover the withdrawal of the corps under harassing fire from horse artillery of Major General J. E. B. Stuart's command.  At the Battle of Bristoe Station later that day, Ricketts' battery F came up at a gallop and unlimbered behind BG Alexander S. Webb's second division II Corps.  Their fire helped defeat Major General Henry Heth's attack on the federal line.  The battery was given the privilege of presenting captured Confederate guns to Major General George G. Meade, the commanding general.

Ricketts' battery remained with the II Corps for the Overland Campaign.  During the Battle of the Wilderness, a section of Ricketts' battery advanced on the Plank Road with Major General Winfield Scott Hancock's attack on the Confederate lines on May 5, 1864, at about 3:30 PM.  The section accompanied BG George Getty's division of VI Corps, serving with Hancock at that time.  A Confederate counterattack captured the section, but Col. Carroll's brigade recaptured the guns by 6:00 PM.  BG Getty praised Ricketts for his "great coolness and courage" in this action.

Ricketts was engaged in support of Grant's offensive attacks on the Confederate positions in the Battle of Spotsylvania Court House on May 18, 1864, being moved up close to the captured Confederate works.  He also supported Hancock's attack on Henagan's redoubt at the Battle of North Anna on May 23.  The battery remained with II Corps throughout the remainder of the campaign, except at the Battle of Cold Harbor, when it was detached to serve with XVIII Corps on June 3,.

Ricketts' battery crossed the James River with II Corps and participated in the Second Battle of Petersburg.  Battery F fired some of the first federal shots into the beleaguered city.  Ricketts' guns were on the battle front for two weeks until they were relieved by a battery from V Corps.

During the subsequent Siege of Petersburg, Ricketts was promoted to higher ranks in the First Pennsylvania Light Artillery.  When Major James H. Cooper reached the expiration of his term of service on August 8, 1864, Ricketts was named his successor.  When, in 1865, Colonel R. M. West was commissioned colonel of the Fifth Pennsylvania Cavalry, Major Ricketts was promoted to the rank of colonel in his place to date from March 15.

During the early stages of the siege, Ricketts continued in command of his battery with II Corps.  This included a role supporting BG Gershom Mott's division in the Second Battle of Deep Bottom.  After returning to the Petersburg front, the battery was assigned to positions near the Jerusalem Plank Road.  During this period, Capt. Ricketts presided over a court of inquiry into the loss of a gun at the Second Battle of Ream's Station.  He also served on a board deciding which units could add the names of particular battles to their flags.  In December 1864, Ricketts, as "acting major," commanded the II Corps batteries serving on the lines of IX Corps for a period of three weeks.

In 1865, Ricketts played a role in the Artillery Reserve; and, by the spring of 1865 he was assistant chief of artillery of IX Corps.  Whenever the chief of artillery, Colonel John C. Tidball, was absent, Ricketts took charge of the guns of IX Corps in his place.

The report that a Confederate veteran looked at Ricketts, a slight man, and commented, "And did this little cuss command Battery Hell!," may be apocryphal.

Post-war
After the war, Ricketts, with his father and an uncle, began buying timber land in Columbia, Luzerne and Sullivan counties.  By 1873, they had ca. .  In 1872 Ricketts and partners opened a saw mill.  He used his own lumber to build North Mountain House at Ganoga Lake in the area where he had his timber lands.  The house took guests until 1903, when it became his family's summer home.  Ricketts' interests suffered financial hardship in the years 1883 to 1885, and he had to sell off much of his land.

Ricketts married Elizabeth Reynolds in Wilkes-Barre, Pennsylvania, on October 1, 1868.  They had three children: William Reynolds (1869–1956); Jean Holberton (1873–1929), and Frances Leigh (1881–1970). Lakes Jean and Leigh are named for their two daughters.

Ricketts belonged to the Grand Army of the Republic and the Military Order of the Loyal Legion of the United States.  The colonel was politically active too.  He supported Major General Winfield Scott Hancock for president in 1880.

At his death on November 14, 1918, at Ganoga Lake, Ricketts still owned about  around Red Rock Mountain in Columbia, Luzerne and Sullivan counties, including Ganoga Lake (or Long Pond) and Lake Jean. Ricketts was buried nearby.  His heirs sold much of this timber land to the state of Pennsylvania via the Central Penn Lumber Company 1920-1924.  This land became the nucleus of Ricketts Glen State Park.

See also

Battle of Gettysburg

References

 "Ghost Towns of North Mountain: Ricketts, Mountain Springs, Stull"
 Gettysburg Battlefield Commission, Pennsylvania at Gettysburg, vol. 2 ([Harrisburg, Pa., W. S. Ray, printer] 1904).
 Minnigh, L. W., Gettysburg: What They Did Here, digitized by Google Books, 2004.
 Obituary in the New York Times, November 14, 1918.
 Pfanz, Harry W., Gettysburg: Culp's Hill and Cemetery Hill, University of North Carolina Press, 1993, .
 Priest, John M., Nowhere to Run: The Wilderness, May 4 & 5th, 1864, Shippensburg: White Mane, 1995.
 Rhea, Gordon C., To the North Anna River: Grant and Lee, May 13–25, 1864, Baton Rouge: Louisiana State University Press, 2000.
 "Ricketts History"
 Sauers, Richard Allen, and Peter Tomasak, Ricketts' Battery: A History of Battery F, 1st Pennsylvania Light Artillery, Luzerne, PA: Luzerne National Bank, 2001.
 Tidball, Eugene, No Disgrace to My Country: the Life of John C. Tidball, Kent, Ohio ; London : Kent State University Press, 2002.
 Walker, Francis Amasa, History of the Second Army Corps in the Army of the Potomac, New York, C. Scribner's Sons, 1886.

1839 births
1918 deaths
Union Army colonels
People from Columbia County, Pennsylvania
People of Pennsylvania in the American Civil War


James Albert Rivers (born September 22, 1945) is a former American football linebacker who played eight seasons in the NFL. Rivers played college football at Bowling Green University.

Rivers was the St. Louis Cardinals fifth-round selection in the 1967 NFL Draft. He started nine games in 1968 and was named the Cardinals team Rookie of the Year. Rivers played in St. Louis from 1968-1973. He was traded to the New York Jets in 1974 where he played his last two seasons.

References

1945 births
Living people
American football linebackers
St. Louis Cardinals (football) players
New York Jets players
Bowling Green Falcons football players
Players of American football from Youngstown, Ohio


Niemann–Pick type C (NPC) (colloquially, "Childhood Alzheimer's") is a lysosomal storage disease associated with mutations in NPC1 and NPC2 genes. Niemann–Pick type C affects an estimated 1:150,000 people. Approximately 50% of cases present before 10 years of age, but manifestations may first be recognized as late as the sixth decade.

Signs and symptoms
Niemann–Pick type C has a wide clinical spectrum. Affected individuals may have enlargement of the spleen (splenomegaly) and liver (hepatomegaly), or enlarged spleen or liver combined (hepatosplenomegaly), but this finding may be absent in later onset cases. Prolonged jaundice or elevated bilirubin can present at birth. In some cases, however, enlargement of the spleen or liver does not occur for months or years – or not at all. Enlargement of the spleen or liver frequently becomes less apparent with time, in contrast to the progression of other lysosomal storage diseases such as Niemann–Pick disease, Types A and B or Gaucher disease. Organ enlargement does not usually cause major complications.

Progressive neurological disease is the hallmark of Niemann–Pick type C disease, and is responsible for disability and premature death in all cases beyond early childhood. Classically, children with NPC may initially present with delays in reaching normal developmental milestones skills before manifesting cognitive decline (dementia).

Neurological signs and symptoms include cerebellar ataxia (unsteady walking with uncoordinated limb movements), dysarthria (slurred speech), dysphagia (difficulty in swallowing), tremor, epilepsy (both partial and generalized), vertical supranuclear palsy (upgaze palsy, downgaze palsy, saccadic palsy or paralysis), sleep inversion, gelastic cataplexy (sudden loss of muscle tone or drop attacks), dystonia (abnormal movements or postures caused by contraction of agonist and antagonist muscles across joints), most commonly begins with inturning of one foot when walking (action dystonia) and may spread to become generalized, spasticity (velocity dependent increase in muscle tone), hypotonia, ptosis (drooping of the upper eyelid), microcephaly (abnormally small head), psychosis, progressive dementia, progressive hearing loss, bipolar disorder, major and psychotic depression that can include hallucinations, delusions, mutism, or stupor.

In the terminal stages of Niemann–Pick type C disease, the patient is bedridden, with complete ophthalmoplegia, loss of volitional movement and severe dementia.

Genetics
Approximately 95% of Niemann–Pick type C cases are caused by genetic mutations in the NPC1 gene, referred to as type C1; 5% are caused by mutations in the NPC2 gene, referred to as type C2. The clinical manifestations of types Niemann–Pick types C1 and C2 are similar because the respective genes are both involved in egress of lipids, particularly cholesterol, from late endosomes or lysosomes. The NPC1 gene is located on chromosome 18 (18q11-q12) and was described by researchers at the National Institutes of Health in July 1997.
 The NPC1 gene encodes a protein that is located in membranes inside the cell and is involved in the movement of cholesterol and lipids within cells. A deficiency of this protein leads to the abnormal buildup of lipids and cholesterol within cell membranes.
 The NPC2 gene encodes a protein that binds and transports cholesterol. It has been shown to closely interact with NPC1.

"Type D" variant

Type D Niemann–Pick has only been found in the French Canadian population of Yarmouth County, Nova Scotia, and is now known to be allelic with Niemann–Pick type C.

Genealogical research indicates that Joseph Muise (c. 1679–1729) and Marie Amirault (1684 – c. 1735) are common ancestors to all people with Type D. This couple is the most likely origin for the type D variant.

Pathophysiology
Niemann–Pick type C is biochemically, genetically and clinically distinct from Niemann–Pick Types A or and B. In Types A and B, there is complete or partial deficiency of the lysosomal enzyme called acid sphingomyelinase. In Niemann–Pick type C, the protein product of the major mutated gene NPC1 is not an enzyme but appears to function as a transporter in the endosomal-lysosomal system, which moves large water-insoluble molecules through the cell. The protein coded by the NPC2 gene more closely resembles an enzyme structurally but seems to act in cooperation with the NPC1 protein in transporting molecules in the cell. The disruption of this transport system results in the accumulation of cholesterol and glycolipids in lysosomes.

Cholesterol and glycolipids have varied roles in the cell. Cholesterol is a major component of cell plasma membranes, which define the cell as a whole and its organelles. It is also the basic building block of steroid hormones, including neurosteroids. In Niemann–Pick type C, large amounts of free or unesterified cholesterol accumulate in lysosomes, and leads to relative deficiency of this molecule in multiple membranes and for steroid synthesis. The accumulation of glycosphingolipids in the nervous system has been linked to structural changes, namely ectopic dendritogenesis and meganeurite formation, and has been targeted therapeutically.

Several theories have attempted to link the accumulation of cholesterol and glycolipids in the lysosomes with the malfunction of the NPC-1 protein.
 Neufeld et al. hypothesized that the accumulation of mannose 6-phosphate receptors (MPRs) in the late endosome signals failure of retrograde trafficking of cholesterol via the trans Golgi network.
 Another theory suggests that the blockage of retrograde cholesterol breakdown in the late endosome is due to decreased membrane elasticity and thus the return vesicles of cholesterol to the trans Golgi Network cannot bud and form.
 Iouannou, et al. have described similarities between the NPC1 protein and members of the resistance-nodulation-division (RND) family of prokaryotic permeases, suggesting a pumping function for NPC1.
 Recent 2008 evidence indicates that NPC-1 may play an important role in calcium regulation.

Diagnosis
Niemann–Pick type C is diagnosed by assaying cultured fibroblasts for cholesterol esterification and staining for unesterified cholesterol with filipin. The fibroblasts are grown from a small skin biopsy taken from a patient with suspected NPC. The diagnosis can be confirmed by identifying mutations in the NPC1 or NPC2 genes in 80–90% of cases. This specialized testing is available at Thomas Jefferson University Lysosomal Disease Testing Lab and the Mayo Clinic.

Treatment
There is no known cure for Niemann–Pick type C, nor is there any FDA-standard approved disease modifying treatment. Supportive care is essential and substantially improves the quality of life of people affected by NPC. The therapeutic team may include specialists in neurology, pulmonology, gastroenterology, psychiatrist, orthopedics, nutrition, physical therapy and occupational therapy. Standard medications used to treat symptoms can be used in NPC patients. As patients develop difficulty with swallowing, food may need to be softened or thickened, and eventually, parents will need to consider placement of a gastrostomy tube (g-tube, feeding tube).

Arimoclomol
In 2014, the European Medicines Agency (EMA) granted orphan drug designation to arimoclomol for the treatment of Niemann–Pick type C. This was followed in 2015 by the U.S. Food and Drug Administration (FDA). Dosing in a placebo-controlled phase II/III clinical trial to investigate treatment for Niemann–Pick type C (for patients with both type C1 and C2) using arimoclomol began in 2016. Arimoclomol, which is orally administered, induces the heat shock response in cells and is well tolerated in humans. In 2018, the Sponsor announced the trial did not meet either its primary or secondary endpoints. On July 17, 2021, the US Food and Drug Administration rejected the New Drug Application for Arimoclomol, and issued a complete response letter to the company Sponsor.

Hydroxypropyl-beta-cyclodextrin (HPbCD)
In April 2009, hydroxypropyl-beta-cyclodextrin (HPbCD) was approved under compassionate use by the U.S. Food and Drug Administration (FDA) to treat Addison and Cassidy Hempel, identical twin girls who had Niemann–Pick type C disease. Medi-ports, similar to ports used to administer chemotherapy drugs, were surgically placed into the twins' chest walls and allow doctors to directly infuse HPbCD into their bloodstreams. Treatment with cyclodextrin has been shown to delay clinical disease onset, reduced intraneuronal storage and secondary markers of neurodegeneration, and significantly increased lifespan in both the Niemann–Pick type C mice and feline models. This is the second time in the United States that cyclodextrin alone has been administered in an attempt treat a fatal pediatric disease. In 1987, HPbCD was used in a medical case involving a boy with severe hypervitaminosis A.

On May 17, 2010, the FDA granted Hydroxypropyl-beta-cyclodextrin orphan drug status and designated HPbCD cyclodextrin as a potential treatment for Niemann–Pick type C disease. On July 14, 2010, Dr. Caroline Hastings of UCSF Benioff Children's Hospital Oakland filed additional applications with the FDA requesting approval to deliver HPbCD directly into the central nervous systems of the twins in an attempt to help HPbCD cross the blood–brain barrier. The request was approved by the FDA on September 23, 2010, and bi-monthly intrathecal injections of HPbCD into the spine were administered starting in October 2010.

On December 25, 2010, the FDA granted approval for HPbCD to be delivered via IV to an additional patient, Peyton Hadley, aged 13, under an IND with Dr. Diane Williams, through Asante Rogue Regional Medical Center in Medford, Oregon. Soon after in March 2011, approval was sought for similar treatment of his sibling, Kayla, age 11, and infusions of HPbCD began shortly after. Both began intrathecal treatments beginning January 2012.  In 2014 Peyton had an intrathecal smart port placed by OHSU's neurosurgeon Dr. Lissa Baird, to alleviate sedation during the intrathecal procedures.  It was successful and continues to be used for treatment (currently 2023). They continue in 2023 to receive both IV and IT treatments; 8 hour IV from home twice monthly, and IT twice monthly at Asante Rogue Regional Medical Center, rotating with IV and IT every week.  These patients have proven safety and benefit shown by NIH Severity Scale Assessments, one slightly less impacted than projected and the other with a profound impact and benefit than projected.

In April 2011, the National Institutes of Health (NIH), in collaboration with the Therapeutics for Rare and Neglected Diseases Program (TRND), announced they were developing a clinical trial utilizing cyclodextrin for Niemann–Pick type C patients.

On September 20, 2011, the European Medicines Agency (EMA) granted HPbCD orphan drug status and designated the compound as a potential treatment for Niemann–Pick type C disease.

On December 31, 2011, the FDA granted approval for IV HPbCD infusions for a fifth child in the United States, Chase DiGiovanni, under a compassionate use protocol. The child was 29 months old at the time of his first intravenous infusion, which was started in January 2012.

Due to unprecedented collaboration between individual physicians and parents of children affected by NPC, approximately 15 patients worldwide have received HPbCD cyclodextrin therapy under compassionate use treatment protocols. Treatment involves a combination of intravenous therapy (IV), intrathecal therapy (IT) and intracerebroventricular (ICV) cyclodextrin therapy.

On January 23, 2013, a formal clinical trial to evaluate HPβCD cyclodextrin therapy as a treatment for Niemann–Pick disease, type C was announced by scientists from the NIH's National Center for Advancing Translational Sciences (NCATS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

In January 2021, the Sponsor (Mallinckrodt Pharmaceuticals) concluded that the benefit / risk balance for HPβCD cyclodextrin (adrabetadex) for the treatment of neurologic symptoms of NPC was negative, and that the risks associated with the treatment outweigh the potential benefit. Effective immediately, Mallinckrodt recommended that treatment with adrabetadex be discontinued as soon as possible, with the appropriate physician oversight.

N-Acetyl-Leucine
N-Acetyl-Leucine is an orally administered, modified amino acid that is being developed as a novel treatment for multiple rare and common neurological disorders by IntraBio Inc.

N-Acetyl-Leucine has been granted multiple orphan drug designations from the U.S. Food & Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of various genetic diseases, including Niemann-Pick Disease Type C. The US FDA has granted IntraBio a Rare Pediatric Disease Designation for N-Acetyl-Leucine for the treatment of NPC.

Observational studies in NPC patients have demonstrated the symptomatic, as well as disease-modifying, neuroprotective effect of treatment. These studies further demonstrated that the treatment is well tolerated, with a good safety profile.

In September 2020, IntraBio announced the successful results of a multinational clinical trial with N-acetyl-L-leucine (IB1001) for NPC, which demonstrated IB1001 demonstrated a statistically significant change in both primary and secondary endpoints, and clinically meaningful improvement in symptoms, functioning, and quality of life.

IntraBio is also conducting parallel clinical trials with N-Acetyl-L-Leucine for the treatment of GM2 Gangliosidosis (Tay-Sachs and Sandhoff) and Ataxia-Telangiectasia. Future opportunities to develop N-Acetyl-Leucine include Lewy body dementia, amyotrophic lateral sclerosis, restless leg syndrome, multiple sclerosis, and migraine.

Other treatments under investigation
One drug that has been tried is Miglustat. Miglustat is a glucosylceramide synthase inhibitor, which inhibits the synthesis of glycosphingolipids in cells. It has been shown to delay the onset of disease in the NPC mouse, and published data from a multi-center clinical trial of Miglustat in the United States and England and from case reports suggests that it may ameliorate the course of human NPC.

Several other treatment strategies are under investigation in cell culture and animal models of NPC. These include, cholesterol mobilization, neurosteroid (a special type of hormone that affects brain and other nerve cells) replacement using allopregnanolone, rab overexpression to bypass the trafficking block (Pagano lab) and Curcumin as an anti-inflammatory and calcium modulatory agent. The pregnane X receptor has been identified as a potential target.

Neural stem cells have also been investigated in an animal model, and clear evidence of life extension in the mouse model has been shown.

Low cholesterol diets are often used, but there is no evidence of efficacy.

Gene therapy is being used clinically to treat genetic diseases including haemophilia and spinal muscular atrophy. It has been used preclinically, in a mouse model of Niemann-Pick type C, using an adeno-associated virus derived viral vector has been shown to extend lifespan following injection into the lateral ventricles of the neonatal brain. In a separate proof-of-concept study a similar vector, but with a modified capsid capable of delivering genes to the central nervous system following intravenous injection, was given to Niemann-Pick type C mice at around four weeks of age; this resulted in extended lifespan and improved weight gain.

Prognosis
The lifespan of patients with NPC is usually related to the age of onset. Children with antenatal or infantile onset usually succumb in the first few months or years of life, whereas adolescent and adult onset forms of Niemann–Pick type C have a more insidious onset and slower progression, and affected individuals may survive to the seventh decade. Adult cases of NPC are being recognized with increasing frequency. It is suspected that many patients affected by NPC are undiagnosed, owing to lack of awareness of the disease and the absence of readily available screening or diagnostic tests. For the same reasons the diagnosis is often delayed by many years.

Research directions
Loss of myelin in the central nervous system is considered to be a main pathogenic factor. Research uses animal models carrying the underlying mutation for Niemann–Pick disease, e.g. a mutation in the NPC1 gene Niemann–Pick type C disease. In this model the expression of Myelin gene Regulatory Factor (MRF) has been shown to be significantly decreased. MRF is a transcription factor of critical importance in the development and maintenance of myelin sheaths. A perturbation of oligodendrocyte maturation and the myelination process might therefore be an underlying mechanism of the neurological deficits.

Recent neuroimaging studies have shown patients with Niemann–Pick, type C to have a corpus callosum with microstructural abnormalities. Clear reductions in corpus callosum mean thickness and surface area have been shown when compared to age-matched controls. Also, studies using diffusion tensor imaging have shown marked reductions in callosal fractional anisotropy, which suggests architectural abnormalities based on the directional flow of water. These conclusions suggest that the corpus callosum plays an important role in the disease and should be explored for use as a biomarker of disease progression.

Parents of children with NPC are being studied in an attempt to gain insight into the Ebola virus, which uses the protein encoded by NPC1 to enter cells. Researchers have found that mice with one normal copy of the NPC1 gene are more likely to survive Ebola infection than mice with normal two copies of the gene. Mice lacking any normal copy of NPC1 all survived. Studying cells from parents who are NPC disease carriers may allow for better understanding of how changes to the NPC1 gene affect Ebola risk.

Findings from Zhang et al. suggest that NPC is a late endocytic trafficking disease resulted, at least in part, from disruption of communication within late endocytic (LE) compartments and possibly between LE and other subcellular organelles. Crosstalk between the late endocytic compartment and other organelles such as mitochondria, endoplasmic reticulum, plasma membrane, as well as early endocytic compartments has become one of the most interesting frontiers in neurondegenerative disease research including Alzheimer's disease, Parkinson's disease, as well as lysosomal storage disorders.

References

External links
 PubMed

Autosomal recessive disorders
Rare diseases
Lipid storage disorders


The 2002 United States Senate election in West Virginia  was held on November 5. Incumbent Democratic U.S. Senator Jay Rockefeller won re-election to a fourth term, defeating Republican Jay Wolfe.

Major candidates

Democratic
 Jay Rockefeller, incumbent U.S. Senator

Republican
 Jay Wolfe, State Senator and nominee for U.S. Senate for 1988

Campaign
Wolfe ran a Grassroots campaign. Rockefeller was the heavy favorite. Rockefeller had $2.9 million cash on hand to Wolfe at $100,536 (In mid-October). Wolfe was endorsed by President George W. Bush and the National Rifle Association of America, but it wasn't enough to make the election competitive.

Predictions

Results

Counties that flipped from Democratic to Republican
 Doddridge (largest municipality: West Union)
 Morgan (largest municipality: Berkeley Springs)
 Grant (largest municipality: Petersburg)
 Ritchie (largest municipality: Harrisville)

See also
 2002 United States Senate elections

References

2002 West Virginia elections
West Virginia
2002


Niemann–Pick disease, SMPD1-associated refers to two different types of Niemann–Pick disease which are associated with the SMPD1 gene.

There are approximately 1,200 cases of NPA and NPB worldwide with the majority of cases being Type B or an intermediate form.

Descriptions of type E and type F have been published, but they are not well characterized, and are currently classified under type B.

Genetics
Mutations in the SMPD1 gene cause Niemann–Pick Types A and B. This gene carries instructions for cells to produce a lysosomal enzyme called acid sphingomyelinase.  Insufficient activity of the enzyme acid sphingomyelinase causes the buildup of toxic amounts of sphingomyelin, a fatty substance present in every cell of the body.  This enzyme is found in special compartments within cells called lysosomes (compartments that digest and recycle materials in the cell), and is required to metabolize the lipid sphingomyelin.  If sphingomyelinase is absent or not functioning properly, sphingomyelin cannot be metabolized properly and is accumulated within the cell, eventually causing cell death and the malfunction of major organ systems.

Diagnosis

Type A
Niemann–Pick Type A, the most common type, occurs in infants and is characterized by jaundice, an enlarged liver, failure to thrive, progressive deterioration of the nervous system and profound brain damage. Children affected by Niemann Pick Type A rarely live beyond 18 months.  Niemann–Pick Type A occurs more frequently among individuals of Ashkenazi (eastern and central European) Jewish descent than in other ethnicities. The incidence within the Ashkenazi population is approximately 1 in 40,000 people. The incidence for other populations is 1 in 250,000 people.

Type B
Niemann–Pick Type B involves an enlarged liver and spleen hepatosplenomegaly, growth retardation, and problems with lung function including frequent lung infections.  Other signs include blood abnormalities such as abnormal cholesterol and lipid levels, and low numbers of blood cells involved in clotting (platelets).  The brain is not affected in Type B and the disease often presents in the pre-teen years.

Treatment

References

External links

Lipid storage disorders
Autosomal recessive disorders


Dennis McFarland (born May 13, 1949) is an American novelist and short story writer. His novels include Nostalgia, Letter from Point Clear, Prince Edward, Singing Boy, A Face at the Window, School for the Blind and The Music Room. His short fiction has appeared in The American Scholar, The New Yorker, Prize Stories: the O’Henry Awards, Best American Short Stories and elsewhere. He has received a fellowship from the National Endowment for the Arts and the Wallace E. Stegner Fellowship from Stanford University.

Life
McFarland was born in Mobile, Alabama, and grew up on a chicken farm. He attended Brooklyn College, where he studied music and composition, as well as Goddard College, where he received his M.F.A. in creative writing. He met the writer and poet Michelle Blake at Goddard and they married in 1983. Together they raised two children and are still married, living now in rural Vermont. They have a small dog with a big underbite.

Career
McFarland's debut novel The Music Room (1990) was a national bestseller, hailed by the New York Times Book Review as "a rare pleasure...A novel of almost organic integrity...Remarkable from its beginning to its surprising, satisfying end." The Hollywood producer Scott Rudin bought the rights and the playwright Robbie Bates was commissioned to write the screenplay.

McFarland's other novels have each been critically acclaimed. His most recent novel, Nostalgia (2013), was described in the New York Times Book Review as "searing, poetic and often masterly...a perfect Civil War novel for our time, or any time." It is the inspiration for a feature film currently underway by River Road.

His short stories have appeared in The American Scholar, The New Yorker, Prize Stories: the O’Henry Awards, Best American Short Stories, and elsewhere.

He has taught writing at Stanford University, where he was a Stegner Fellow, as well as Emerson College. In 1991, he received a fellowship from the National Endowment for the Arts.

Works

Novels
 The Music Room (1990)
School for the Blind (1994)
A Face at the Window (1997)
Singing Boy (2001)
Prince Edward (2004)
Letter from Point Clear (2007)
 Nostalgia (2013)

Anthologies
 Prize Stories: The O'Henry Awards (1990)
 "Nothing to Ask For," Best American Short Stories (1990)
 "A Gentle Plea for Chaos," A Few Thousand Words about Love (1998)

References

External links
 Official Dennis McFarland website
 Dennis McFarland at the Random House website
 Books by Dennis McFarland at Open Library
 Dennis McFarland's stories at The American Scholar

Living people
20th-century American novelists
21st-century American novelists
American male novelists
Goddard College alumni
Brooklyn College alumni
Stanford University alumni
Stanford University faculty
20th-century American male writers
21st-century American male writers
1949 births


California Proposition 14 may refer to three different and unrelated propositions proposed in California:

California Proposition 14 (1964), concerning housing discrimination
California Proposition 14 (2010), concerning the election system
California Proposition 14 (2020), concerning biomedical research into embryonic stem cells


The Moneypaper is a monthly financial newsletter published by The Moneypaper, Inc. that is geared towards the small investor and long-term investing strategies.  Its name comes from the original format of the publication, that of a newspaper.  Its current format is that of a magazine.  New issues are released every month.

History
Vita Nelson first had the idea for The Moneypaper in 1981, shortly after selling her previous publishing venture, Westchester Magazine, in 1980.   With the help of publisher Joyce Gruenberg, Circulation manager Lucy Banker, and Executive Editor Mark Fowler, the first issue of The Moneypaper was published in April 1982, with the subheading “A Financial Publication for Women.”  The subheading was removed beginning with the December 1985 issue when Vita "started hearing from men who read the newsletter but subscribed to it under their wives' names."

The Moneypaper contains a mixture of commentary and financial data, and includes a section that summarizes important financial news and trends, as well as suggestions on stock portfolios to build and stock picks from equity specialists  Currently, it is based in Harrison, NY.

Media Mentions
A subscription to The Moneypaper was among the suggestions for fiscally aware gifts in the Dec. 18, 1994 issue of the LA Times.

External links
 The Moneypaper Website
 Moneypaper Fact Sheet

Notes

Moneypaper


Corey May is an American video game writer. He is currently the Narrative Director for Austin video game developer Certain Affinity. May is also the co-founder and President of Sekretagent Productions, a production company based in Los Angeles, California working in the film, video game, and internet industries. May is the main writer of the Assassin's Creed series.
May worked as the lead writer on Assassin's Creed, Assassin's Creed II, and Assassin's Creed III. Corey May also helped Jeffrey Yohalem as a writer on Assassin's Creed: Brotherhood, and Darby McDevitt on Assassin's Creed: Revelations. May helped Jeffrey Yohalem once again on Assassin's Creed Syndicate, making it the last game he worked on before departing from Ubisoft. May also helps in the production of most other entries into the Assassin's Creed franchise to make sure everything flows together into one coherent narrative.

May graduated from Harvard University in 1999 and founded Sekretagent with Dooma Wendschuh upon their graduation from the University of Southern California's Peter Stark Producing Program in 2001.

Along with Dooma Wendschuh, May has co-written for video games such as Prince of Persia: Warrior Within, Prince of Persia: The Two Thrones, Army of Two and Terminator Salvation. He also was an executive producer on the 2006 horror film The Plague, was a producer on the 2002 film Yo, Tyrone.

He and Wendschuh wrote the Batman video game developed by WB Games Montréal, Batman: Arkham Origins, a prequel to Rocksteady Studios Batman video games: Batman: Arkham Asylum, Batman: Arkham City and Batman: Arkham Knight.

Biography

Early life
Corey May was raised near Hollywood. May's interest in films, comics, games and anime came from a young age. However, his family wanted him to initially attend Harvard University to become a doctor. May failed in Chem 5 and realized that medicine wasn't his future. May then decided to take BA and several English courses, including literature courses and creative writing courses. He took a class on Eastern European science fiction and read many books, but still intended to be an investment banker or a trader. In the summers, May took jobs at a variety of banks in New York City, but was rejected several times due to his appearance. However, he did receive a job to copy edit reports and journal articles.

Career

Sekretagent Productions
After college in early 2000s, May decided to apply to the Peter Stark Producing program at USC. At USC, May met his business partner, Dooma Wendschuh, and after graduation they made their production company official. They printed business cards and letterhead. Thanks to some contacts made during a Disney internship, the duo sold its first project to Disney: a re-envisioned live-action The Wind in the Willows. Many writers and directors including Guillermo del Toro have been attached.

Ubisoft (2004-2011)
Off the success of the first project, the duo signed with a film agency. The agency received many requests for writing on video games. Having loved the medium since childhood, May decided they should at least take the meetings, where he first met Ubisoft. May and Wendschuh pitched Ubisoft an animated television show based on Rayman. Despite rejecting the pitch, the executives did like May, and invited him to visit Montreal. After the critical success of Prince of Persia: The Sands of Time and Beyond Good & Evil, the publisher wanted May to help with the next Prince of Persia game, Prince of Persia: Warrior Within.

May then started working on Assassin's Creed for four years. "It was this big crazy weird super ambitious monstrosity. How are we going to go from what's in the creative director's head to what's on a disc? [...] As time went on I was more and more involved with the franchise, charting some of the aspects of its future. Not just writing on the games but overseeing the narrative elements of the brand as a whole," said May.

Alice (2011-Present)

Alice was originally formed in 2011 by Yves Jacquier, Ubisoft's director of production services. Alice's main goal was to improve stories in Ubisoft games. "It is a resource composed of talent scouts, motion capture masters, research and development engineers, sound mixers and narrative guides," reads a report from Alice.

The first game to see significant support from Alice was Watch Dogs. Michael Mando, who played Vaas in Far Cry 3, was also motion captured in Alice.

Video games

Awards and nominations

References

External links

American film producers
American video game designers
Video game writers
Place of birth missing (living people)
Year of birth missing (living people)
Living people
Harvard University alumni
USC School of Cinematic Arts alumni
Ubisoft people


Robert C. Flowers (August 6, 1917 – December 8, 1962) was an American football player who played eight seasons for the Green Bay Packers.

1917 births
American football offensive linemen
Texas Tech Red Raiders football players
Green Bay Packers players
1962 deaths
People from Big Spring, Texas


The men's 82.5 kg powerlifting event at the 2008 Summer Paralympics was contested on 15 September at the Beihang University Gymnasium in Beijing, China. This event was the fourth-heaviest of the men's powerlifting weight classes, limiting competitors to a maximum of  of body mass. Powerlifters were divided into two groups, A and B, with group B beginning their lifts at 13:00 and group A at 13:45.

As with all Paralympic powerlifting events, lifters competed in the bench press. Each athlete was allowed three attempts to bench press as much weight as possible. Athletes attempting to break a record were allowed a fourth attempt. For the attempt to be valid, the competitor must have lowered the weighted bar to his chest, held it motionless for a moment, then pressed the bar upwards until his arms were fully extended. If the competitor failed to meet these requirements or any other rule infraction was committed, the attempt was declared invalid by a team of three referees and the result struck from the record.

Results

Key: NMR=No marks recorded

References

Men's 082.5 kg


Lebian (Lebiantu) (died September 1776) was toqui from 1769 to 1774, who led the Pehuenche against the Spanish Empire in Chile following the Mapuche Uprising of 1766 during the Arauco War.

Life
During the war, in 1769 Lebian led a malón against the region of Laja River and Los Ángeles taking cattle and destroying every estancia in their path. Spanish troops sent against him were defeated and forced to retire to Los Ángeles. Encouraged by the victory Lebian attacked fort Santa Bárbara two days later, although repulsed with some losses, they managed to set fire to the town and to take the cattle found in the area.

At the end of the war he was part of the delegation sent to Santiago to make peace in 1774. The same year he was also involved in a feud against the toqui Ayllapagui.

Assassination
In September 1776, according to Gov. Agustín de Jáuregui's policy of rewarding loyalty, Lebian was named distinguished soldier of the Spanish Army, and travelled to the city of Los Angeles for a meeting with the maestre de campo Ambrosio O'Higgins. As he was returning to his country, a band of Spaniards ambushed and killed him. One of the suspects was a captain Dionisio Contreras, but nothing was proved against him. It was rumored that O'Higgins had arranged the death as part of a policy of eliminating by such means hostile or strong Mapuche leaders in preference to open warfare, but O'Higgins denied responsibility for the ambush, persecuted the assassins and hanged one of them.

Additional information

See also
Arauco War
Agustín de Jáuregui
Ambrosio O'Higgins

Notes

Sources

18th-century Mapuche people
People of the Arauco War
1776 in the Captaincy General of Chile
Indigenous leaders of the Americas
Year of birth unknown
1776 deaths
18th-century military personnel


Utrechtse Sportvereniging Hercules (Utrecht Sports Association Hercules), also known as USV Hercules or Hercules Utrecht, is an amateur football club in Utrecht, Netherlands. In 2014 it joined the Derde Divisie (then still known as Topklasse) after playing just one year in the Hoofdklasse.

History
In 2017, USV Hercules led 1–0 against FC Groningen in the national KNVB Cup but went on to lose the game, 1–2.

In the 2021–22 season, USV Hercules qualified for the promotion playoffs, but lost 6–3 on aggregate to DVS '33 in the first round.

Hercules qualified for the promotion playoffs again in the 2022–23 season. However they lost 3-1 on aggregate to GVVV in the second round.

References

External links
 Official site

Multi-sport clubs in the Netherlands
Football clubs in the Netherlands
Football clubs in Utrecht (city)
Sports clubs and teams in Utrecht (city)
Association football clubs established in 1882
1882 establishments in the Netherlands


Hermann Julius Grüneberg (11 April 1827 – 7 June 1894) was a German chemist and inventor, and together with Julius Vorster the founder of the Chemische Fabrik Kalk.

Biography
Grüneberg was born on 11 April 1827 in Stettin, Province of Pomerania, Prussia, now Szczecin, the capital city of West Pomeranian Voivodeship in Poland. He was the second of six children of the master organ builder August Wilhelm Grüneberg and his wife Caroline Henriette née Breslich from Cammin. One of his brothers was Barnim Grüneberg, who took over his father's organ building business. He died on 7 June 1894 in Cologne, German Empire where he was buried in the Melaten Cemetery.

Honours
A school, the Grüneberg-Schule, and a street, Grünebergstraße, in Kalk, a district of Cologne, are named after him.

See also
Chemische Fabrik Kalk
Julius Vorster

Bibliography

External links
  Webpage on Herman Julius Grüneberg

1827 births
1894 deaths
19th-century German chemists
German company founders
German chemical industry people
19th-century German businesspeople
Businesspeople from Szczecin
People from the Province of Pomerania
Scientists from Szczecin


Kanerva is a Finnish surname which is also used as a unisex given name. Notable people with the surname include:

Emma Kanerva (born 1985), Finnish dressage rider
Ilkka Kanerva (1948–2022), Finnish politician
Janne Kanerva (born 1970), Finnish weightlifter
Markku Kanerva (born 1964), Finnish football manager and former player
Pentti Kanerva, American neuroscientist
Silja Kanerva (born 1985), Finnish sailor
William Kanerva (1902–1956), Finnish football player

See also
 Kanervo

References

Finnish-language surnames
Finnish feminine given names
Finnish masculine given names


A list of windmills in Buckinghamshire, UK.

Locations

Mock mill

Sources
Unless stated otherwise, the source for all entries is

Maps
1788 Thomas Jeffrey
1834 Ordnance Survey

Notes
Mills in bold are still standing, known building dates are indicated in bold. Text in italics denotes indicates that the information is not confirmed, but is likely to be the case stated.

References

Buckinghamshire
Windmills


Brad Inman may refer to:

Brad Inman (soccer) (born 1991), footballer who plays for Western United
Bradley Inman, Internet entrepreneur and founder of several companies