Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.

References

Further reading


These are the official results of the Women's 1500 metres event at the 1986 European Championships in Stuttgart, West Germany, held at Neckarstadion on 29 and 31 August 1986.

Medalists

Final

Qualifying heats

Participation
According to an unofficial count, 20 athletes from 14 countries participated in the event.

 (1)
 (1)
 (1)
 (1)
 (1)
 (1)
 (1)
 (1)
 (3)
 (3)
 (1)
 (3)
 (1)
 (1)

See also
 1982 Women's European Championships 1500 metres (Athens)
 1983 Women's World Championships 1500 metres (Helsinki)
 1984 Women's Olympic 1500 metres (Los Angeles)
 1987 Women's World Championships 1500 metres (Rome)
 1988 Women's Olympic 1500 metres (Seoul)
 1990 Women's European Championships 1500 metres (Split)

References

 Results

1500
1500 metres at the European Athletics Championships
1986 in women's athletics


L-2-hydroxyglutarate dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the L2HGDH gene, also known as C14orf160,  on chromosome 14.

Function

This gene encodes L-2-hydroxyglutarate dehydrogenase, a flavin adenine dinucleotide (FAD)-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe mental retardation.

L2HGDH codes for a protein that is 50 kDa in size. The L2HGDH protein contains a mitochondrial-targeting transit peptide and is localized to the mitochondrial inner membrane inside mitochondria inside the cell. The L2HGDH protein catalyzes the following reaction,  and  requires flavin adenine dinucleotide (FAD) as a co-factor:

(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

L-2-hydroxyglutarate is produced by promiscuous action of malate dehydrogenase on 2-oxoglutarate; the L2HGDH protein is thus an example of a metabolite repair enzyme because it reconverts the useless damage product L-2-hydroxyglutarate back to 2-oxoglutarate.

Clinical significance

Mutations in the L2HGDH gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder. Individuals with L2HGDH mutations present toxic accumulation of high concentration of L-2-hydroxyglutaric acid in the plasma and cerebrospinal fluid. At least 70 disease-causing variants in the L2HGDH gene have been discovered in patients. Patients with L-2-hydroxyglutaric aciduria are associated with moderate to severe mental retardation, psychomotor retardation, cerebellar ataxia, macrocephaly, or epilepsy.

L2HGDH has a role in mediating differentiation in T-cells via its activity on S-2HG

Molecular interactions

KLK10

See also
 D2HGDH
 2-hydroxyglutarate synthase
 2-hydroxyglutarate dehydrogenase
 Hydroxyacid-oxoacid transhydrogenase

References

Further reading


Protein POF1B is a protein that in humans is encoded by the POF1B gene.

References

Further reading


RecQ-mediated genome instability protein 1 is a protein that in humans is encoded by the RMI1 gene.

Genetic disorders
Mutations in RMI1 are associated with Bloom-Syndrome like disorder. Two patients, both with microcephalic dwarfism came from the same family. They carried identical heterozygous mutations: [1255_1259del][Lys419LeufsTer5].

Function
RMI1 protein is a component of the Bloom Syndrome Complex. RMI1 protein is made up of 2 OB (oligonucleotide binding) domains. OB1 binds to Topoisomerase III alpha, while OB2 binds to RMI2 within the Bloom Syndrome complex, and FANCM of the Fanconi Anaemia pathway.

An insert within OB1 domain of RMI1 inserts into the catalytic centre of Topoisomerase III alpha, and is necessary for the optimal activity of this enzyme during cellular DNA repair and homologous recombination.

Meiosis
During meiosis in budding yeast Saccharomyces cerevisiae, TOP3 (a type I topoisomerase) and its accessory factor RMI1 form a heterodimer that functions to allow passage of one DNA single strand through another. The TOP3-RMI1 heterodimer associates with Sgs1 (Bloom helicase ortholog) to form a complex that catalyzes dissolution of double Holliday junctions.  Furthermore, the TOP3-RMI1 heterodimer participates in all meiotic recombination functions associated with Sgs1, most significantly as an early recombination intermediate chaperone, promoting regulated crossover and non-crossover recombination and preventing accumulation of aberrant recombination intermediates. In particular, the TOP3-RMI1–SGS1 complex promotes early formation of non-crossover recombinants during meiosis.

References

Further reading


NIP30 protein is a protein that in humans is encoded by the FAM192A gene.

References

Further reading


Proteasomal ATPase-associated factor 1 is an enzyme that in humans is encoded by the PAAF1 gene.

Interactions

PAAF1 has been shown to interact with PSMD10.

References

Further reading


Otta Station () is a railway station located in the town of Otta in Sel, Norway. The station is located on the Dovre Line and served by express trains to Oslo and Trondheim. The station was opened in 1896 when the Dovre Line was extended from Tretten Station to Otta.

The restaurant was taken over by Norsk Spisevognselskap on 1 October 1924. It retained an all-year operation until 30 September 1928, when the restaurant was closed for the winter season. It opened again in May and retained the summer-only service. The operation was later privatized.

References

Railway stations in Oppland
Railway stations on the Dovre Line
Railway stations opened in 1896
1896 establishments in Norway
Sel
Railway stations in Norway opened in the 1890s


Calcyphosin is a protein that in humans is encoded by the CAPS gene.

Function

This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants.

References

Further reading

EF-hand-containing proteins


HMS Deptford was a 50-gun fourth-rate ship of the line of the Royal Navy, launched at Woolwich Dockyard in 1687.

She underwent her first rebuild at Woolwich in 1700 as a fourth rate of between 46 and 54 guns. Her second rebuild took place at Portsmouth Dockyard, where she was reconstructed as a 50-gun fourth rate to the 1706 Establishment and relaunched on 19 June 1719.

She was captained in 1710 by Sir Tancred Robinson.

Deptford was sold out of the navy c.1725.

Notes

References

Ships of the line of the Royal Navy
1680s ships


Zinc finger protein 239 is a protein that in humans is encoded by the ZNF239 gene.

Function

MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures.

Interactions

ZNF239 has been shown to interact with LMNA.

References

Further reading

\*

External links

Transcription factors


Protein DGCR6 is a protein that in humans is encoded by the DGCR6 gene.

DiGeorge syndrome, and more widely, the CATCH 22 syndrome, are associated with microdeletions in chromosomal region 22q11.2. This gene product shares homology with the Drosophila melanogaster gonadal protein, which participates in gonadal and germ cell development, and with the human laminin gamma-1 chain, which upon polymerization with alpha- and beta-chains forms the laminin molecule. Laminin binds to cells through interaction with a receptor and has functions in cell attachment, migration, and tissue organization during development. This gene could be a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome.

References

Further reading


José Parra Martínez (28 August 1925 – 29 February 2016) was a Spanish footballer who played as a defender.

Club career
Born in Blanes, Province of Girona, Catalonia, Parra's professional career was entirely spent with RCD Español in his native region. He signed with the club in 1947 from neighbouring Terrassa FC, going on to compete with the former in 12 La Liga seasons.

Parra scored his first and only league goal for the Pericos on 17 October 1948, in a 5–0 home win against RC Celta de Vigo. He retired in June 1960 at nearly 35, after a spell with Cartagena FC.

International career
Parra earned seven caps for Spain in one year. His first came on 9 April 1950, in a 2–2 away draw with Portugal for the 1950 FIFA World Cup qualifiers.

Selected by manager Guillermo Eizaguirre for the finals in Brazil, Parra played five times during the tournament to help to a final fourth place.

Death
Parra died on 29 February 2016 in Terrassa, at the age of 90. He was the last survivor of the team that appeared in the 1950 World Cup.

References

External links

1925 births
2016 deaths
People from Selva
Footballers from the Province of Girona
Spanish men's footballers
Men's association football defenders
La Liga players
Tercera División players
Terrassa FC footballers
RCD Espanyol footballers
Cartagena FC players
Spain men's B international footballers
Spain men's international footballers
1950 FIFA World Cup players
Catalonia men's international footballers


U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene.

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly.

References

Further reading


Héctor Manzanilla Rangel (born June 28, 1985 in Los Teques, Miranda) is a Venezuelan bantamweight boxer who has won a bronze medal at the Central American Games. He is most respected for giving amateur superstar Guillermo Rigondeaux one of the toughest fights of his career.

Career
At the Central American Games 2006 he lost to Mexican Arturo Santos Reyes in the semis.

At the ALBA Games in May 2007 in his home country he gave two-time Olympic champion who came into this fight on a 96 bout winning streak since 2003 one of his toughest fights losing only on countback +8:8 (36:38). (The 5:0 score on Rigondeaux's amateur record is misleading, all five judges voted for him).

He didn't participate in the PanAm Games 2007.

At the 2007 World Amateur Boxing Championships where he lost to Enkhbatyn Badar-Uugan in the quarter final he qualified for the Olympics.

As of 2007 his record is 179-15.

External links
 Central American Games 2006
 World Championships 2007
 Bio/Record (Spanish)

Living people
Bantamweight boxers
Boxers at the 2008 Summer Olympics
Olympic boxers for Venezuela
People from Los Teques
Sportspeople from Miranda (state)
1985 births
Venezuelan male boxers
Central American and Caribbean Games bronze medalists for Venezuela
Competitors at the 2006 Central American and Caribbean Games
South American Games gold medalists for Venezuela
South American Games medalists in boxing
Competitors at the 2006 South American Games
Central American and Caribbean Games medalists in boxing
20th-century Venezuelan people
21st-century Venezuelan people


Wall is a village in Northumberland, England situated to the north of Hexham close by the River North Tyne and Hadrian's Wall. The Battle of Heavenfield was fought nearby. The village has one pub and a garage.

Governance

Wall is in the parliamentary constituency of Hexham.

Transport
Wall was served by Wall railway station on the Border Counties Railway which linked the Newcastle and Carlisle Railway, near Hexham, with the Border Union Railway at Riccarton Junction. The first section of the route was opened between Hexham and Chollerford in 1858, the remainder opening in 1862. The line was closed to passengers by British Railways in 1956.

The station, and signal box, still stands and is now in use as a private house.

References

Villages in Northumberland
Civil parishes in Northumberland


RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene. It is named after the RUN and FYVE domains it contains.

Interactions

RUFY1 has been shown to interact with BMX.

References

Further reading


Michael Jordan in Flight is a 1993 computer basketball game for DOS. It was developed by and published by Electronic Arts and is endorsed by Michael Jordan although it has no NBA licensed players or teams.

Gameplay

The game featured a three-a-side basketball match. The camera is a 3D camera, and the game includes some filmed scenes of Michael Jordan. The game is developed in a court surrounded by nothing (even with no crowd the player can hear clapping sometimes).

Reception
Computer Gaming World praised the "incredible ... 3D-based graphic engine" as being "so far ahead of everyone else", but criticized Michael Jordan in Flight as being too easy because "the product is based on Michael Jordan. Jordan is too good overall". The magazine concluded that it "is the most visually realistic sports software on the market ... Now, they need to apply the technology to a game".

References

External links
 Michael Jordan in Flight at thelegacy.de

1993 video games
DOS games
DOS-only games
Basketball video games
Cultural depictions of Michael Jordan
Video games based on real people
Video games developed in the United States
Video games featuring black protagonists


William Brent Bell is an American film director, screenwriter, and producer. He is known for his work on horror films such as Stay Alive (2006), The Devil Inside (2012), Wer (2013), The Boy (2016), Brahms: The Boy II (2020), Separation (2021), Orphan: First Kill (2022), and Lord of Misrule (2023). His films have grossed over $300 million worldwide at the box office.

Life and career
Bell was born in Lexington, Kentucky. Along with writing partner Matthew Peterman, Bell wrote the screenplay Mercury, which was bought by Universal Studios with Gale Anne Hurd producing. Bell and Peterman went on to set up several studio projects. Some include Ignition, an action-drama set up at Warner Bros. with Kurt Russell and Goldie Hawn producing and Illusion, a thriller set up at Walt Disney Pictures. On the television side the duo created several one-hour TV series including Eye to Eye with Warner Bros. Television and McG, Worthy and McGraw with ABC Television and Tim Minear as well as The Fix with Sarah Timberman and Sony Television.  Bell and Peterman have also developed a number of videogames including Master Thief, with John Woo.

Bell's first horror project was as co-writer and director of the horror thriller, Stay Alive, which was produced with McG and Peter Schlessel and financed by Spyglass Entertainment and Endgame Entertainment.  Stay Alive was distributed domestically by Buena Vista Pictures and internationally by Universal Pictures. His second horror film was The Devil Inside, written with Matt Peterman. Produced by Peterman and Morris Paulson, the film stars Fernanda Andrade, Simon Quarterman, Evan Helmuth, and Suzan Crowley, and was released theatrically on January 6 by Paramount Pictures. The film topped the US box office on its opening weekend, becoming a record-breaking commercial success and grossing over $100 million.

In 2013, Bell went into production on his third horror film, Wer which was released by Focus Features. Nav Qateel of Influx Magazine called Wer, "the best Werewolf film I've seen in years, or perhaps, ever." Epic Horror Review wrote, "Wer not only redefines the werewolf movie but also saves it." Wer would go on to be described by horrornews.net as, "One of the best films I've seen so far this year and a must to watch." and "a film that you want to not only watch but add to your collection" by wickedchannel.com

In 2014, Bell sold his pilot Posthuman to USA Network and UCP with Jason Blum producing. In 2015, Bell set up a series at Fox entitled Haunted with Chris Morgan of the Fast & Furious franchise. This 20th Century Fox Television production is loosely based on the true story chronicled in the book The Demon of Brownsville Road: A Pittsburgh Family's Battle with Evil.

In 2015, Bell would direct the supernatural thriller The Boy, which Tom Rosenberg and Gary Lucchesi produced through Lakeshore Entertainment, along with Matt Berenson, Jim Wedaa, and Roy Lee. The script was written by Stacey Menear and starred Lauren Cohan, Jim Norton, Diana Hardcastle, Ben Robson, Rupert Evans, and James Russell. STX Entertainment released The Boy on January 22, 2016, and it went on to gross a worldwide total of $77 million, against a budget of under $8 million. Chris Alexander of ShockTilYouDrop called it "one of the best contemporary wide release horror movies I've seen in years." Joe Leydon criticized the story line as average in Variety and commented, "Despite game efforts by the cast, this tepid horror opus is never scary enough to overcome its silly premise." In 2017, GQ Magazine called the film, "the most underrated horror movie of 2016."

In 2019 Bell directed the sequel Brahms: The Boy II, a supernatural horror film starring Katie Holmes, Ralph Ineson, Christopher Convery and Owain Yeoman. The stand-alone sequel to the 2016 film The Boy was written by Stacey Menear and released on February 21, 2020. Later that year, Bell directed and produced Separation, an American horror film, from a screenplay by Nick Amadeus and Josh Braun. It stars Rupert Friend, Violet McGraw, Mamie Gummer, Madeline Brewer and Brian Cox. In March 2021, Open Road Films and Briarcliff Entertainment acquired distribution rights to the film, and released it on April 30, 2021.

In 2021, Bell directed Orphan: First Kill, an American horror film from a screenplay by David Coggeshall. It is a prequel to the 2009 film Orphan. David Leslie Johnson-McGoldrick serves as executive producer. Isabelle Fuhrman reprises her role as Esther, with Julia Stiles also starring. In September 2021, Paramount Pictures acquired U.S. distribution rights to the film, Orphan: First Kill was released in the United States on August 19, by Paramount Players in select theatres, digital, and streaming via Paramount+. , Orphan: First Kill has grossed $5.4 million in the United States and Canada, and $39.1 million in other territories, for a worldwide total of $44.5 million. On review aggregator Rotten Tomatoes, the film holds an approval rating of 72% based on 137 reviews

Bell is currently in post production on Lord of Misrule, an upcoming folk horror film starring Tuppence Middleton, Ralph Ineson, and Matt Stokoe.

Filmography

References

External links

American television producers
American male screenwriters
Living people
American male television writers
Writers from Lexington, Kentucky
Film directors from Kentucky
Screenwriters from Kentucky
Film producers from Kentucky
Horror film directors
Year of birth missing (living people)


Khuddar ( Self-Respecting) is a 1994 Indian Hindi-language action film directed by Iqbal Durrani and starring Govinda, Karishma Kapoor and Kader Khan, is a remake of the Tamil film Walter Vetrivel, starring Sathyaraj. Other cast includes Shakti Kapoor, Shreeram Lagoo, Anjana Mumtaz, Raju Shrestha, Mahesh Anand, Vikas Anand, Navneet Nishaan and Anil Dhawan. The film includes the controversial number "Sexy Sexy Mujhe Log Bole", which was censored to "Baby Baby Mujhe Log Bole". The song itself is inspired from Italian singer Sabrina Salerno 1987 hit, Boys. Dialogues of this movie became very popular, and therefore, audio cassettes of dialogues were released.

Plot
Shastri Suri (Shreeram Lagoo) comes from a middle-class yet honest background. He has raised his son, police inspector Siddhant Suri (Govinda) and daughter Bindiya and second son Nandu (Raju Shrestha) in a similar way. But Nandu has fallen into bad company. He is part of a gang which kidnaps women for sex trafficking, led by Babujaan (Mahesh Anand) and Kapaali (Jack Gaud). After the gang targets Pooja (Karisma Kapoor), she turns witness to the police, and as a result, Pooja is attacked and loses her sight. A blind Pooja subsequently weds Siddhant, not knowing that her assailant is her brother-in-law. Shastriji's employee Kanhaiyalal (Kader Khan) is greedy and ambitious. When Shastriji stands for election, he is opposed strongly by corrupt and avaricious Adarsh Vardhan (Shakti Kapoor). By hook and crook, Adarsh wins the election and decides to humiliate the Suri family. He asks that his bodyguard be none other than Siddhant Suri. Siddhant must now choose between staying with the police force and serving his corrupt master.

Siddhant chooses to serve, but only so that he can find out more about the corrupt minister and his dealings and to reveal the same to the public. Siddhant finally discloses the same to the public gathered in a rally, and the minister is forced to flee the scene. Pooja's eyes are operated upon, and her vision is restored. She identifies Nandu, and Siddhant takes revenge on his brother.

Cast
Govinda as Police Inspector Siddhant Suri, Pooja's husband
Karishma Kapoor as Pooja Suri, Siddhant's wife
Kader Khan as Kanhaiyalal
Shakti Kapoor as Adarsh Vardhan
Shreeram Lagoo as Shastri Suri
Anjana Mumtaz as Mrs Suri
Raju Shrestha as Nandkishore “Nandu” Suri
Aarti Nagpal as Bindiya, Siddhant's sister
Mahesh Anand as Babujaan
Vikas Anand as Doctor
Achyut Potdar as Police Commissioner
Navneet Nishan as Jenny
Anil Dhawan as Press Reporter
Adi Irani as Anand
Rami Reddy as Swami
Jack Gaud as Kapali
Subbiraj as Father of Adarsh Vardhan (Uncredited) Seen only in the photo frame

Soundtrack

Govinda's accident
Govinda narrowly escaped death on 5 January 1994 while traveling to a studio for the shooting of Khuddar. The actor's car collided with another car, resulting in him sustaining injuries to his head. Though bleeding profusely, Govinda did not cancel the shooting. After visiting a doctor, he shot for the film till midnight.

References

External links

1994 films
1990s Hindi-language films
Indian action films
Hindi remakes of Tamil films
Fictional portrayals of the Maharashtra Police
Films scored by Anu Malik
Indian police films
1994 action films
1990s police films


Centrosomal protein of 63 kDa is a protein that in humans is encoded by the CEP63 gene.   Several alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Function

This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Recent computational analysis revealed pathogenic property of L61P point mutation in CEP63 protein that affected its native structural conformation.

Interactions

CEP63 has been shown to interact with DISC1, CEP152 and CDK1.

References

External links

Further reading

Centrosome


ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene.

References

Further reading


tRNA pseudouridine synthase A is an enzyme that in humans is encoded by the PUS1 gene.

PUS1 converts uridine into pseudouridine after the nucleotide has been incorporated into RNA. Pseudouridine may have a functional role in tRNAs and may assist in the peptidyl transfer reaction of rRNAs.[supplied by OMIM]. The mutations in PUS1 gene has been linked to mitochondrial myopathy and sideroblastic anemia.

See also
Pseudouridine kinase
Mitochondrial tRNA pseudouridine27/28 synthase
TRNA pseudouridine38/39 synthase
TRNA pseudouridine32 synthase

References

Further reading

EC 5.4.99


Kv channel-interacting protein 4 is a protein that in humans is encoded by the KCNIP4 gene.

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Interactions
KCNIP4 has been shown to interact with PSEN2.

See also
 Voltage-gated potassium channel

References

Further reading

External links

Ion channels
EF-hand-containing proteins


Kvam Station is a railway station located at the town of Kvam in Nord-Fron, Norway. The station is located on the Dovre Line and served regional trains with one departure southwards to Lillehammer and one to Oslo each day. Too the north there is one departure to Åndalsnes and one to Dombås each day. The station was opened in 1896 when the Dovre Line was extended from Tretten Station to Otta Station.

Railway stations in Oppland
Railway stations on the Dovre Line
Railway stations opened in 1896
1896 establishments in Norway
Railway stations in Norway opened in the 1890s


Patatin-like phospholipase domain-containing protein 3 (PNPLA3) also known as adiponutrin (ADPN), acylglycerol O-acyltransferase or calcium-independent phospholipase A2-epsilon (iPLA2-epsilon)  is an enzyme that in humans is encoded by the PNPLA3 gene.

Function

Adiponutrin is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.

Genomics

The gene is located on the long arm of chromosome 22 at band 13.31 (22q13.31). It lies on the Watson (plus) strand and is 40,750 bases in length.

Upstream of the gene, putative binding sites for several transcription factors have been identified. These include PPAR-gamma, POU2F1, and POU2F2. If any of these transcriptions factors are actually involved in the regulation of this gene is not known at present.

Biochemistry

The recommended name for the gene product is patatin-like phospholipase domain-containing protein 3. It is a Single-pass type II membrane protein and is a multifunctional enzyme with both triacylglycerol lipase and acylglycerol O-acyltransferase activities.  It is involved in the triacylglycerol hydrolysis in adipocytes and may play a role in energy metabolism.

The mature protein is 481 amino acids in length and the predicted molecular weight is 52.865 kiloDaltons (kDa). Two of the isoforms have been described, but the functional significance - if any - of these forms is not known.

Clinical relevance

An association between alcoholic liver disease in caucasians and variations in this gene has been confirmed.  A mutation of isoleucine to methionine (I[ATC]>M[ATG]) SNP rs738409 has been confirmed to increase susceptibility to non-alcoholic liver disease and also to have effects in diabetes.

References

Further reading

EC 3.1.1


Berštejn Castle is a 16th-century Czech castle located just outside the village of Dubá in the Doksy municipality. Berštejn  also refers to a chateau near the castle.

Starý Berštejn
Starý Berštejn (old Berštejn) is now merely a ruin situated on a hilltop outside of Dubá.

Nový Berštejn
Nový Berštejn (new Berštejn) is a chateau just north of Dubá which has been converted to a hotel.

References

External links
berstejn.com

Hotels in the Czech Republic
Castles in the Liberec Region
Česká Lípa District


TRAF3-interacting JNK-activating modulator is a protein that in humans is encoded by the TRAF3IP3 gene.

Model organisms

Model organisms have been used in the study of TRAF3IP3 function. A conditional knockout mouse line, called Traf3ip3tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on homozygous mutant mice and two significant abnormalities were observed. Males had a decrease in white blood cell count and females had an increased susceptibility to bacterial infection.

Interactions

TRAF3IP3 has been shown to interact with STRN, MOBKL3, STK24 and FAM40A.

References

Further reading

Genes mutated in mice


This is a list of students associations in Canada.

Alberta

British Columbia

Manitoba

Newfoundland & Labrador

New Brunswick

See also
 New Brunswick Student Alliance

Nova Scotia

See also
 Alliance of Nova Scotia Student Associations
 Students Nova Scotia
 Canadian Federation of Students - Nova Scotia

Ontario

Prince Edward Island

Quebec

Saskatchewan

The Territories

National
 Black Law Students' Association of Canada
 Canadian Alliance of Student Associations
 Canadian Federation of Students
 Canadian Federation of Engineering Students
 Ukrainian Canadian Students’ Union
 Undergraduates of Canadian Research Intensive Universities
 Canadian Association of Business Students

Canada


Zinc finger protein 34 is a protein that in humans is encoded by the ZNF34 gene.

References

Further reading

External links

Transcription factors


Federico Rizzi (born 6 January 1981 in Cremona) is an Italian footballer. He plays for U.S. Salernitana 1919.

Career
Rizzi started his career at Pizzighettone in Province of Cremona. He played from Serie D and followed to club to reach Serie C1 in summer 2005.

In summer 2006, he was signed by Mantova of Serie B. After just made 5 appearances in 2007–08 season, he joined league rival Triestina on loan in mid-season.

External links
 gazzetta.it
http://aic.football.it/scheda/13412/rizzi-federico.htm

1981 births
Living people
Italian men's footballers
AS Pizzighettone players
Mantova 1911 players
US Triestina Calcio 1918 players
Taranto FC 1927 players
US Cremonese players
SSD FC Trapani 1905 players
Serie B players
Men's association football defenders
Sportspeople from Cremona
Footballers from the Province of Cremona
Men's association football midfielders


Discografía Completa: Edición Especial Gira 98 is a quadruple album that contains Alejandro Sanz's previous albums, it was edited for the 1998 Tour Más.

Track listing

CD1 (Viviendo Deprisa)
 Los Dos Cogidos de la Mano - 5:02
 Pisando Fuerte - 4:28
 Lo Que Fui Es lo Que Soy - 4:40
 Todo Sigue Igual - 5:13
 Viviendo Deprisa - 3:17
 Se Le Apagó la Luz - 4:46
 Duelo al Amanecer - 3:31
 Completamente Loca - 3:32
 Toca Para Mi - 4:07
 Es Este Amor - 3:34

CD2 (Si Tú Me Miras)
 Si Tú Me Miras - 4:14
 Tu Letra Podré Acariciar - 3:34
 El Escaparate - 4:46
 Cómo Te Echo de Menos - 4:00
 Cuando Acabas Tú - 4:01
 Mi Primera Canción - 4:36
 Vente al Más Allá - 3:56
 Qué No Te Daría Yo - 3:34
 Este Pobre Mortal - 3:36
 A Golpes Contra el Calendario - 5:02

CD3 (3)
 La Fuerza del Corazón - 5:05
 Por Bandera - 4:59
 Mi Soledad y Yo - 4:57
 Ellos Son Así - 4:39
 Quiero Morir en Tu Veneno (D'Romy Ledo, Adolfo Rubio, Alejandro Sanz) - 4:02
 ¿Lo Ves? - 3:48
 Canción Sin Emoción - 4:48
 Eres Mía - 5:25
 Ese Que Me Dio Vida - 3:58
 Se Me Olvidó Todo al Verte - 4:39
 ¿Lo Ves? (piano y voz) - 3:35

CD4 (Más)
 Y, ¿Si Fuera Ella? - 5:22
 Ese Último Momento - 5:04
 Corazón Partío - 5:46
 Siempre Es de Noche - 4:47
 La Margarita Dijo No - 4:52
 Hoy Que No Estás - 5:10
 Un Charquito de Estrellas - 4:50
 Amiga Mía - 4:48
 Si Hay Dios... - 5:36
 Aquello Que Me Diste - 4:46

Album certifications

References

Alejandro Sanz compilation albums
1998 compilation albums


Miwa (みわ, ミワ) is a feminine Japanese given name which can also be used as a surname.

Possible writings
Miwa can be written using different kanji characters and can mean:
三和 "three, harmony"
三輪 "three, wheel/ring"
美和 "beauty, harmony"
美羽 "beauty, feather"
美輪 "beauty, wheel/ring"
美環 "beauty, ring; circle; loop"
The given name can also be written in hiragana or katakana.

People
with the given name Miwa
 Miwa (singer) (born 1990), a musician who sung the theme song for the drama Nakanai to Kimeta Hi
 Miwa Asao (美和, born 1986), a beach volleyball player
 Miwa Fukuhara (美和, born 1944), a figure skater
, Japanese women's basketball player
 Miwa Matsumoto (美和, born 1971), a voice actress
 Miwa Nishikawa (美和, born 1974), a director
 Miwa Oshiro (大城 美和, born 1983), gravure idol, model and actress
, Japanese cross-country skier
 Miwa Ueda (美和, 21st century), a manga artist
 Miwa Yasuda (美和, born 1977), a voice actress
 Miwa Yoshida (美和, born 1965), lead singer of the band Dreams Come True
 Miwa Takada (美和, born 1947), an actress

with the surname Miwa
 Akihiro Miwa (美輪, born 1935), a singer, actor, and theatre director
, Japanese actress
 Sadahiro Miwa (三輪 定広, born 1941), Olympic weightlifter
 Shigeyoshi Miwa (三輪, born 1892), an admiral in the Imperial Japanese Navy
 Shirow Miwa (三輪, born 1978), a manga artist
, Japanese racewalker
 Takashi Miwa (三輪, born 1969), a former professional baseball player
 Teppei Miwa (三輪 哲平, born 2000), Japanese artistic gymnast
 Tetsuji Miwa (三輪 哲二,, born 1949), Japanese mathematician
 Tetsuya Miwa (三輪), the guitarist of the rock band Spitz

Fictional characters
with the given name Miwa
Miwa Hamato, a recurring character in the 2012 of Teenage Mutant Ninja Turtles. She is the biological daughter of Hamato Yoshi and the late Tang Shen, but was abducted by the Shredder as an infant and was renamed Karai.
Miwa Tamashiro (美和), a character in the anime series Kotetsushin Jeeg
Miwa Isono, a character in the manga series MPD Psycho
Miwa Kageyama (美羽), the sister of Tobio Kageyama from the anime and manga series Haikyū!!
With the surname Miwa
Satoshi Miwa (三輪), a character in the manga and anime Marmalade Boy
Sakamori Miwa (三輪), a character in the anime series Tōshō Daimos
Ichigen Miwa (三輪 一言), a character in the anime series K
Shinobu Miwa (三輪), a character in the anime, manga, and novel series RahXephon
Konekomaru Miwa (三輪), a character in Blue Exorcist
Kasumi Miwa (三輪霞), a character in Jujutsu Kaisen

Japanese feminine given names
Feminine given names
Japanese-language surnames


HMS St Albans was a 50-gun fourth rate ship of the line of the English Royal Navy, launched at Deptford Dockyard in 1687. The ship fought in the Battle of Placentia (1692).

St Albans was wrecked in 1693.

Notes

References

Lavery, Brian (2003) The Ship of the Line - Volume 1: The development of the battlefleet 1650-1850. Conway Maritime Press. .

Ships of the line of the Royal Navy
1680s ships


Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene. Expressed in the gut, it has antibiotic properties.

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.

References

External links

Further reading


Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.

Interactions

ILKAP has been shown to interact with Integrin-linked kinase.

References

Further reading


Carlos Patricio Díaz (born July 21, 1970) is a Chilean-born Canadian film and television actor who appears in Rent-a-Goalie, The Dead Zone and The Line. Díaz and the cast of Rent-a-Goalie were nominated for a Gemini Award in 2007, 2008 and 2009 in Seasons 1 through 3 for "Best Ensemble Performance in a Comedy Program or Series".

Filmography
 Rosie's Rules (2022–present) (TV series) - Papa
 Johnny Test (2021-present) (TV series) - Pow-ool
 Hero Elementary (2020–present) (TV series) - Mr. Sparks
 Total Drama Presents: The Ridonculous Race (2015) (TV series) - Lorenzo/Rock (15 episodes)
 Fargo (2014) (TV series) - Young Stavros (1 episode)
 Cra$h & Burn (formerly "Lawyers, Guns and Money") (2009) (TV series) - Carlos Galindo (12 episodes)
 Max & Ruby - Mr Estevez
 The Adventures of Leo & Cleo (2010) (TV series) - (voice)- Fresco (16 episodes)
 Saw 3D (2010) - Coroner Worker
 The Bridge (2009) (TV series) - parts dealer (1 episode)
 How To Be Indie (2009) (TV series) - Sensei Jeff (1 episode)
 Lawyers, Guns & Money (2008) (TV Pilot) - Carlos (pilot)
 Clean (2008) (TV Pilot) - Carl (pilot)
 The Lines  (2007–2008) - Mike (5 episodes)
 Rent-a-Goalie (2006–2008) (TV series) - Looch (26 episodes)
 Otro lado del pasillo, El (2006) (Best Short film—MethodFest)- Miguel
 The Very Good Adventures of Yam Roll in Happy Kingdom (2006) (TV series) (voice)- Ebi (unknown episodes)
 Four Brothers (2005) - baffled cop
 Cool Money (2005) (TV) - bank officer
 Hu$tle (2004) (TV) - Mike Bertolini
 Evel Knievel (2004) (TV) - DJ Caruso
 The Dead Zone (2004) (TV series) - Rick Fanuli (1 episode)
 Franny's Feet (2003-2010) (TV series) - Johnny (4 episodes)
 Crime Spree (2003) - Hector
 Adventure Inc. (2003) (TV series) - parts dealer (1 episode)
 Street Time (2002) (TV series) - Tony Rodriguez (1 episode)
 Lucky Day (2002) (TV) - Officer Miller
 John Q (2002) - Paramedic #1
 The Save-Ums! (2003) (TV series) (voice) - Raymundo the ant (8 episodes)
 Boss of Bosses (2001) (TV) - Philip Castellano
 Chasing Cain (2001) (TV)- Neil
 Hangman (2001) - Officer Peros
 RoboCop: Prime Directives (2000) (TV mini-series) - Jenkins OCPThe Uncles (2000) - Eddie the Waiter
 The Seventh Portal (2000) (TV series) - Oxblood/Roberto Diaz (voice)
 The Avengers: United They Stand'' (1999) (TV series) - Tiger Shark (voice)

External links

1970 births
Living people
Canadian male film actors
Canadian male television actors
Canadian male voice actors
Chilean emigrants to Canada
Canadian people of Chilean descent
Male actors from Santiago


Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene.

The WNT gene family consists of structurally-related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates two transcript variants.

References

Further reading


Fairview Mall may refer to the following shopping centres in Canada:

 Fairview Mall, Toronto, Ontario
 CF Fairview Park (formerly known as Fairview Park Mall), Kitchener, Ontario
 Fairview Pointe-Claire, Pointe-Claire, Quebec


Vinstra Station is a railway station located at the village of Vinstra in Nord-Fron, Norway. The station is located on the Dovre Line and served express trains to Oslo and Trondheim. The station was opened in 1896 when the Dovre Line was extended from Tretten to Otta.

Railway stations in Oppland
Railway stations on the Dovre Line
Railway stations opened in 1896
1896 establishments in Norway
Railway stations in Norway opened in the 1890s


Hajee Mohammad Danesh Science and Technology University (HSTU) ) is a government-financed public university of Bangladesh. Locally it is known as Hajee Danesh University.

History

Hajee Mohammad Danesh Science and Technology University is the first Science and Technology University in the northern region of Bangladesh. It stands away from the urban Dinajpur and bustle at a beautiful and scenic location some 13km north of Dinajpur town by the side of the intercity highway that links Dinajpur to Dhaka, the capital of Bangladesh. Hajee Mohammad Danesh Science and Technology University was established as an Agricultural Extension Training Institute (AETI) to award a three-year diploma in agriculture. The AETI was later upgraded to Hajee Mohammad Danesh Agricultural College in 1988 having an affiliation with the Bangladesh Agricultural University, Mymensingh. Then the college was upgraded to the status of a university renaming it as Hajee Mohammad Danesh Science and Technology University. The first batch of students were admitted at that time (1999-2000 session). The Act of the University was passed on 8 July 2001 in the Jatio Shongsad (National Assembly) followed by a gazette notification on 8 April 2002.

Campus

Dhaka-Dinajpur highway is located next to the campus. The distance of the campus from Dinajpur City is only 10 km. This University has a ceremony for green plants. There is a magnificent red-white brick building, Shahid Minar, a gymnasium, TSC, and a canteen in memory of martyrs.

The infrastructure includes a large central Jame Masjid, central Shaheed Minar, 5 academic buildings, an administrative building, 5 student hostels (one for international students), 3 female student hostels, a 100-seat VIP seminar room with modern furnishings, two more with 600 and 250 seats. Air-conditioned auditorium. Also, to complete a university, there are teachers-staff and staff club, 2 mosques, 136 residential units/buildings, 1 children's park, post office, Rupali Bank branch, Meghna Bank branch, workers barracks, round the clock internet facility, own electric line, large playground. , engineering workshops, and the University's own transport system for students. Institute of Research and Training (IRT) for coordination and smooth conduct of research and training. There is a V. I. Also a 12 bedded medical center with P Guest House, Habiprabi School, Doctor, and Ambulance. Along with researched theses, reports, and journals, there is a rich library of 25 thousand books. A rich botanical garden with an interesting collection of rare plants and Jamparsnajm Center for Research under the supervision of various departments.

List of vice-chancellors
The following persons served as Vice Chancellor in Haji Mohammad Danesh Science and Technology University:

Campus

Library

HSTU Library is a well furnished multi storied building. It is doing its daily activities by different sections, such as: Acquisition section, Circulation section, Processing section and Reference section which are situated at different location in the Library Building. Administrative section of the library does the administrative activities. Acquisition Section is always working hard to collect the all kind of required documents of the users. Recently it has collected a great deal of different types of books for different faculties of this university. Circulation section sets on the ground floor of the library building. All the researchers, students and teachers of this university may borrow their required books as per rule from the Circulation Section for reading the book outside of the library or home. Only those books that are more than 2 copies are available for loan to students/ teachers/ researchers. Processing section is doing an important job. It prepares the catalogue and classification all kind of documents by using the AACR-2 code and D.D.C. scheme. It is located on the ground floor of the library building. Reference section is another important section. It is situated at the first floor and second floor of the building. Teachers, researchers and students may read the rare documents sitting in the Reference Section. It also provides photocopy facility against a nominal fee. Another important service of this section is current awareness service. It regularly sends the list of current received documents to the faculties. Thesis, 73 titled home and abroad journals and 15 Daily newspapers are kept at the 2nd floor of the building. All kind of users can read the journal, daily newspaper and thesis here. There is a cyber center in the Library. All users may use the cyber center against a nominal fee.

Medical centre
The medical center offers free medical service to students, Medical Centerteachers, staffs and family members of the teachers and staff. The center provides service round-the-clock, seven-days-a-week, with five doctors and ambulance facility. The center has 10 bed accommodation so that patients suffering from contagious diseases may be cared for in isolation. HSTU Medical center is also offering outdoor facilities.

Muktijuddho Corner
.

Transport

.

Halls of residence

Male Halls
 Sheikh Russel Hall
 Shaheed President Ziaur Rahman Hall (D-2)
 Tajuddin Ahmed Hall
 Bangabandhu Sheikh Mujibur Rahman Hall

Female Halls
 Sheikh Fajilatunnesa Mujib Hall
Ivy Rahman Hall
Kobi Sufia Kamal Hall
 New Ladies Hall (Name not fixed yet)
An extended area for foreign students.

International Halls
 An extended area for intrenation students.

Faculties

There are 9 faculties in HSTU with 45 departments:
 Faculty of Postgraduate
 Faculty of Agriculture
 Department of Agronomy (AGN)
 Department of Horticulture (HRT)
 Department of Soil Science (SC)
 Department of Entomology (ENT)
 Department of Plant Pathology (PLP)
 Department of Genetics and Plant Breeding (GPB)
 Department of Crop Physiology and Ecology (CPE)
 Department of Agricultural Extension (AEX)
 Department of Agricultural Chemistry (ACH)
 Department of Agroforestry and Environment (AGF)
 Department of Biochemistry and Molecular Biology (BMB)
 Faculty of Computer Science and Engineering
 Department of Computer Science and Engineering (CSE)
 Department of Electronics and  Communication Engineering (ECE)
 Department of Electrical and Electronic Engineering (EEE)
 Faculty of Business Studies:
 Department of Accounting (ACT)
 Department of Management Studies (MGT)
 Department of Marketing (MKT)
 Department of Finance and Banking (FIB)
 Faculty of Fisheries
 Department of Fisheries Biology and Genetics (FBG)
 Department of Fisheries Management (FMG)
 Department of Fisheries Technology (FTL)
 Department of Aquaculture (AQC)
 Faculty of Veterinary & Animal Science
 Department of Microbiology (MIC)
 Department of Pathology and Parasitology (PPS)
 Department of Dairy and Poultry Science (DPS)
 Department of Anatomy and Histology (ANH)
 Department of General Animal Science and Nutrition (GASN)
 Department of Genetics and Animal Breeding (GAB)
 Department of Medicine, Surgery and Obstetrics (MSO)
 Department of Physiology and Pharmacology (PPH)
 Faculty of Engineering
 Department of Agricultural and Industrial Engineering (AIE)
 Department of Food Processing and Preservation (FPP)
 Department of Food Engineering and Technology (FET)
 Department of Food Science and Nutrition (FSN)
 Department of Architecture (ARCH)
 Department of Civil Engineering (CE)
 Department of Mechanical Engineering (ME)
 Faculty of Science:
 Department of Chemistry (CHE)
 Department of Statistics (STAT)
 Department of Mathematics (MAT)
 Department of Physics (PHY)
 Faculty of Social Science & Arts
 Department of English (ENG)
 Department of Economics (ECN)
 Department of Sociology (SOC)
 Department of Development Studies (DS)

Academics

Degrees offered
The university offers 23 undergraduate degrees under 9 faculties along with several postgraduate and doctoral courses.

Undergraduate degree programs

There are 1525 seats available for undergraduate admission.

Postgraduate degree programs
 Faculty of Postgraduate Studies:
 PhD
 MA
 MS
 MBA
 Evening MBA

Research
Three years of research under Md. Hasanuzzaman, Chairman of the Genetics and Plant Breeding Department, led in 2014 to two new varieties of sweet pumpkins. The varieties, named "Hajee" and "Danesh", are higher yielding, sweeter, and have less fiber than other varieties grown in Bangladesh.

Student life

Sports
The university organises sports and other extracurricular and recreational activities. It provides intramural and extramural programmes.
Sports Club
HSTU FC(Football club)
HSTU Cricket Club
HSTU Blade Skating
The directorate organizes and conducts interdepartmental and inter-hall tournaments, individual hall athletics, university athletics, and inter-university games and sports. Students participate in national championships in games and sports for which training and coaching are offered.

See also
Military Institute of Science and Technology (MIST)

References

External links

 Official Website
 HSTU Students Affaaris & Advisory Division (SAAD-HSTU)

Public universities of Bangladesh
Educational institutions established in 2002
2002 establishments in Bangladesh
Universities of science and technology in Bangladesh
Organisations based in Dinajpur


HMS Sedgemoor was a 50-gun fourth rate ship of the line of the English Royal Navy, launched at Chatham Dockyard in 1687.

Sedgemoor was driven ashore and wrecked at South Foreland, Kent on 2 January 1689.

Notes

References

Lavery, Brian (2003) The Ship of the Line - Volume 1: The development of the battlefleet 1650-1850. Conway Maritime Press. .

Ships of the line of the Royal Navy
1680s ships
Maritime incidents in 1689


Complement factor H-related protein 5 is a protein that in humans is encoded by the CFHR5 gene.

Function
CFHR5 is structurally related to complement factor H which plays an important role in the regulation of a branch of the innate immune system called the alternative complement pathway. Like complement factor H, CFHR5 is able to bind to complement C3.

Clinical Significance
A mutation in CHFR5 was found in patients with the disease CFHR5 nephropathy, which is a common cause of renal disease in Cyprus. The mutated form of the protein found in patients with this disease has impaired ability to bind to complement C3, suggesting that CFHR5 is important in protecting the kidneys from attack by the complement system.

References

External links
  GeneReviews/NCBI/NIH/UW entry on Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II

Further reading


Father Joe Devlin was one of the three American Jesuits during the Vietnam War that went to Vietnam and helped the refugees. He was important in securing the passage of several thousand Cambodian refugees to America. He built an orphanage in Thailand which housed, fed, and schooled several hundred abandoned children.

After his death, Father Joe's brother wrote his biography which he entitled
"Cha".

Early life
When Joe was growing up, his family lived at 431 Jersey St. in San Francisco, a few blocks from church, and also a few blocks from the local library.

References

"Cha"
Author: Raymond A. Devlin
Title: Cha
Copyright (c) 2001 by Raymond A. Devlin

External links
 Father Joe

20th-century American Jesuits
Roman Catholic missionaries in Vietnam
American Roman Catholic missionaries
Year of death missing
Year of birth missing
Roman Catholic missionaries in Thailand
Jesuit missionaries
American expatriates in Vietnam
American expatriates in Thailand
Clergy from San Francisco
Catholics from California


Sphingosine-1-phosphate phosphatase 1 is an enzyme that in humans is encoded by the SGPP1 gene.

References

Further reading


Dezső Gyarmati (23 October 1927 – 18 August 2013) was a Hungarian professional water polo player and three-time Olympic champion; he later became the coach of the Hungarian national water polo team. Widely regarded as a "legendary player", Gyarmati was the most decorated player in the history of the sport.

Early life and family
Dezső Gyarmati was born in Miskolc, Borsod-Abaúj-Zemplén.

He married Éva Székely, a swimmer who was the 1952 Olympic champion in the 200-metre breaststroke. Their daughter Andrea Gyarmati has competed as a backstroke and butterfly swimmer; she received two Olympic medals in 1972, and is a one-time world record holder for the 100 metres butterfly.

Player career
As a left-handed utility player, Gyarmati could play in all positions of the field. He was the most successful water polo player in the history of the Olympics. He participated in five different Summer Olympics, winning three gold medals with the Hungarian team at the 1952 Summer Olympics in Helsinki, the 1956 Summer Olympics in Melbourne, and the 1964 Summer Olympics in Tokyo. His team received silver medals at the 1948 Summer Olympics in London, and bronze medals at the 1960 Summer Olympics in Rome. Gyarmati became European Champion two times, in 1954 and in 1962. He is widely considered the greatest water polo player of all time.

Gyarmati played a total of 108 matches with the Hungary national team. He was among the fastest water polo players of his time, with a personal record of 58.5 seconds for 100 meters.

Gyarmati played in the famous Blood in the Water match between Hungary and the Soviet Union at the 1956 Olympics, which occurred weeks after the Soviet invasion of Hungary. FINA stated that while it is usually "remembered as the 'Blood bath of Melbourne' after the scenes of the dying minutes, it was team captain Gyarmati who opened the scoring and set up the other three goals Hungary netted while winning 4-0 en route to the title."

Coaching and administrative career

After his competitive years, Gyarmati began working as a water polo coach. He left Europe to coach the Colombian national team from 1970-1971.

Gyarmati then returned to Europe and, from 1972 to 1980, coached the Hungary men's national team. He led them again from 1985 to 1988. Under his coaching, the team gained gold medals at 1976 Summer Olympics in Montreal, a silver medal at the 1972 Summer Olympics in Munich, and the bronze medal at the 1980 Summer Olympics in Moscow, making him one of the most successful water polo coaches in Olympic history, and one of a few sportspeople who won Olympic medals in water polo as players and head coaches. They also won the inaugural editions of both the FINA World Championship (in 1973) and the FINA World Cup (in 1979), as well as the European Championship in 1974 and 1977. They were runners-up in the World Championship in 1975 and 1978.

In the 1980s Gyamarti coached Hungarian club teams to several medals in the national league.

Gyarmati served as a member of the board of the Hungarian Water Polo Federation. He also wrote several books about water polo, including a history of Hungarian water polo.

Political career
After the 1989 break-up of the Soviet Union and Eastern Bloc, Gyamarti entered politics. Benefitting from his achievements and name recognition, he was elected Member of Parliament from the National List of the Hungarian Democratic Forum (MDF) in the 1990 Hungarian parliamentary election. He served as a member of the Committee on Municipality, Public Administration, Internal Security and Police.

He unsuccessfully ran for a parliamentary seat during the 1994 and 1998 parliamentary elections. In 2003, he was appointed as Chairman of the Sports Section of the Fidesz's Cultural Department.

Awards

In addition to his Olympic medals, he received other recognition of his achievements:

1976, Gyarmati was inducted into the International Swimming Hall of Fame. He was awarded the title of Athlete of the Nation in 2004.
He received the Commander's Cross of the Order of Merit of the Republic of Hungary in 1994.
In 2010, he received the Grand Cross (the highest civilian award for a non-head of state).

Death
Gyarmati died in Budapest on 18 August 2013 at the age of 85. In a statement, FINA said that they were "in mourning", calling him one of the best water polo players of all time. FINA described him thus: "The left-handed genius could play in all positions of the field. Known for his fearless approach in every game, he was able to decide the biggest clashes single-handedly."

FINA in their statement said that, despite a long illness and "broken" health, he had attended Hungary's last match before the 2013 World Championship and watched Hungary's victory in the Championship from his hospital bed.

See also
 Hungary men's Olympic water polo team records and statistics
 List of athletes with the most appearances at Olympic Games
 List of players who have appeared in multiple men's Olympic water polo tournaments
 List of multiple Olympic medalists in one event
 List of multiple Olympic gold medalists in one event
 List of Olympic champions in men's water polo
 List of Olympic medalists in water polo (men)
 List of world champions in men's water polo
 List of members of the International Swimming Hall of Fame
 Blood in the Water match

References

External links

1927 births
2013 deaths
Sportspeople from Miskolc
Hungarian male water polo players
Left-handed water polo players
Water polo utility players
Water polo players at the 1948 Summer Olympics
Water polo players at the 1952 Summer Olympics
Water polo players at the 1956 Summer Olympics
Water polo players at the 1960 Summer Olympics
Water polo players at the 1964 Summer Olympics
Olympic gold medalists for Hungary in water polo
Olympic silver medalists for Hungary in water polo
Olympic bronze medalists for Hungary in water polo
Medalists at the 1948 Summer Olympics
Medalists at the 1952 Summer Olympics
Medalists at the 1956 Summer Olympics
Medalists at the 1960 Summer Olympics
Medalists at the 1964 Summer Olympics
Hungarian water polo coaches
Hungary men's national water polo team coaches
Water polo coaches at the 1972 Summer Olympics
Water polo coaches at the 1976 Summer Olympics
Water polo coaches at the 1980 Summer Olympics
Members of the National Assembly of Hungary (1990–1994)
Hungarian sports executives and administrators
Hungarian sportsperson-politicians
Expatriate sports coaches
Hungarian expatriate sportspeople in Colombia
Hungarian defectors
Hungarian expatriates in the United States


Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001).[supplied by OMIM]

References

Further reading

Solute carrier family


Peter Kerr (born 26 April 1967, in Scotland) is a Scottish political scientist.  He is a senior lecturer at the University of Birmingham and a specialist in British politics, political sociology, state theory and theories of social and political change. He specialises and teaches in the area of British politics, with a particular focus on governmental strategies, UK political parties, political leadership and ideology in the UK and, changes and continuities in British political institutions and public policy since 1945.

Kerr studied Politics and Sociology at the University of Strathclyde and then for his PhD on the Thatcher governments at Birmingham.

Kerr authored Postwar British Politics: From Conflict to Consensus in 2001. In the book, Kerr challenges conventional views of British politics. He was the protégé of the British political scientists Colin Hay and David Marsh.

Kerr is a co-editor of the journal British Politics published by Palgrave Macmillan.

Personal life
Kerr has performed stand-up comedy. Kerr once appeared on Secrets of the sexes, a one-off BBC television programme about sex and dating.

He has described himself as "one of the many people in Britain who are not a member of any political party!"

References

External links
 Homepage at the University of Birmingham

1967 births
Academics of the University of Birmingham
Living people
Scottish political scientists
Place of birth missing (living people)


Thioredoxin-related transmembrane protein 1 is a protein that in humans is encoded by the TMX1 gene.

References

Further reading

Endoplasmic reticulum resident proteins


Radeberger started in 1872 when the brewery was founded as Zum Bergkeller, in Radeberg, a town in the vicinity of Dresden. Radeberger ranks No. 9 among Germany's best selling beers.

History
This beer was also brewed for a period for the King of Saxony. It was the first brewery in Germany to brew beer exclusively in the Pilsner style that still exists today.
Radeberger elected to change its name to the present name of Radeberger Exportbierbrauerei.  This change came in 1885 when they began shipping across borders. By the late 1880s, the brewer's numbers had risen to 300,000 cases per year.
The first German chancellor, Otto von Bismarck elevated Radeberger Pilsner to "Kanzler-Bräu" (chancellor brew) in 1887. The brewery takes pride in the fact that in 1905, Radeberger Pilsner became the favourite drink of king Frederick Augustus III of Saxony. Also that same year, Radeberger began to export to the USA and Canada.

In 1946, the communist East German government took control of the brewery. In 1954, the company began to export worldwide.
In 1990, after the fall of the Berlin Wall, Binding Brauerei purchased the company and returned its sales to West Germany. After the purchase, the brewery underwent comprehensive renovations to bring the brewery up to speed with modern brewing. By 1994, it expanded to 1 million Hectoliter production rate. In 2004, Oetker Gruppe purchased the company and removed them from the stock market, thus making Radeberger a private company.

Radeberger was the favourite beer of the character Charlie Harper in the TV series Two and a Half Men due to a cooperation with the brewery. Vladimir Putin, assigned by KGB to their office in Dresden, DDR, in the 1980s, assisting the East German Stasi and also supervising them, acquired a taste for Radeberger, which remains his preferred beer, in Russia, and when he travels to the European Union.

They also brew 'Uberbrau' for Wesfarmers in the Australian market.

See also

Henninger Brewery
 List of brewing companies in Germany

Notes

External links

Official Homepage of the Brewery
Radeberger Brewery tour

Breweries in Germany
Beer brands of Germany
Saxon Royal Warrant holders
1872 establishments in Germany
Food and drink companies established in 1872
Companies based in Saxony
brewery
Dr. Oetker


Melanoma-associated antigen D4 is a protein that in humans is encoded by the MAGED4B gene.

This gene is related to members of the MAGED gene family, in terms of the sequence similarity and the chromosome location. This gene is expressed only in brain and ovary among normal tissues, and two transcript variants of this gene are specifically expressed in glioma cells among cancer cells. This gene and the other MAGED genes are clustered on chromosome Xp11. Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined.

References

Further reading


Ankyrin repeat domain-containing protein 13C is a protein that in humans is encoded by the ANKRD13C gene.

Protein interactions

ANKRD13C is predicted to interact with Transmembrane Protein Domain 255A (TMEM255A).

References

Further reading

External links


Iron-sulfur cluster assembly 1 homolog, mitochondrial is an evolutionarily highly conserved protein for the biogenesis of iron-sulfur cluster across species. In humans it is encoded by the ISCA1 gene.

References

Further reading


Ringebu Station () is a railway station located at the village of Ringebu, Norway. The station is located on the Dovre Line and served express trains to Oslo and Trondheim. The station was opened in 1896 when the Dovre Line was extended from Tretten to Otta.

The station restaurant was taken over by Norsk Spisevognselskap on 1 January 1926. It was transferred back to private operation from 1932, but then again operated by Spisevognselskapet from 15 March 1942.

References

External links

 Jernbaneverket page on Ringebu

Railway stations in Oppland
Railway stations on the Dovre Line
Railway stations opened in 1896
1896 establishments in Norway
Ringebu
Railway stations in Norway opened in the 1890s


Dedicator of cytokinesis protein 8 (Dock8) is a large (~190 kDa) protein encoded in the human by the DOCK8 gene, involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G-proteins.

Discovery
Dock8 was identified during a yeast two hybrid (YTH) screen for proteins that interact with the Rho family small G protein Cdc42. Subsequent northern blot analysis revealed high levels of Dock8 expression in the placenta, lung, kidney and pancreas as well as lower levels in the heart, brain and skeletal muscle.

Function
Dock8 shares the same core domain arrangement as all other DOCK proteins, with a DHR2 domain which, in other proteins, contains GEF activity and a DHR1 domain known, in other proteins, to interact with phospholipids. In the YTH system Dock8 was reported to interact with both Rac1 and Cdc42. However, no stable interaction between Dock8 and these small G proteins was observed in a GST-pulldown assay. This may be due to the fact many DOCK-G protein interactions require the presence of adaptor proteins to stabilise the complex and thus facilitate nucleotide exchange.

Clinical significance

A mutation in the DOCK8 gene is associated with the autosomal recessive form of Job's syndrome or hyper-IgE Syndrome. It is manifested in infancy and the patient survives till late childhood or adolescence. The disease is characterized by eczema, recurrent cold staphylococcal abscesses, recurrent lung infections, coarse facial features, primary teeth remnants (2 rows of teeth present), high IgE levels and eosinophilia.

Somatic mutations
Despite the fact that little is known about the cellular role of Dock8 its importance has been highlighted in several studies which have identified disruption of the DOCK8 gene in disease. Deletion and reduced expression of Dock8 have been reported in a human lung cancer cell line and Dock8 was also identified as a putative candidate gene associated with progression of gliomas.

Clinical significance of germline mutations
Autosomal recessive DOCK8 deficiency is associated with a variant of combined immunodeficiency. This variant of Hyperimmunoglobulin E syndrome (HIES) was first described in 2004  and this clinical entity is known to be due to having biallelic germline mutations in the DOCK8 gene.  HIES due to DOCK8-deficiency has a distinct clinical presentation compared to other forms of HIES and in inherited in an autosomal recessive manner.

The clinical manifestations of DOCK8 immunodefiency include recurrent infections, allergies, and malignancies. Nearly all patients have recurrent or chronic upper and lower respiratory tract infections, with many requiring sinus surgery and myringotomy tube placement.  Recurrent lung infections may lead to bronchiectasis or damage to the airways leaving them widened and scarred.  The cutaneous or skin infections are distinctive and include severe and difficult to treat viral infections, such as herpes simplex virus, human papilloma virus, and molluscum contagiosum; bacteria such as Staphylococcus aureus; as well as fungal infections of the mouth or skin with Candida.  Eczema is common, and can be quite severe and further complicated by bacterial infection.  Together, these skin infections can become disfiguring.

DOCK8 immunodefiency patients frequently have allergies to many food and environmental allergens, as well as asthma. Autoimmunity has been seen in some patients, such as autoimmune hemolytic anemia, as well as vasculitis and vasculopathy.  Patients are also at increased risk for developing squamous cell carcinomas and lymphoid malignancies. Some but not all lymphomas are associated with poor control of the cancer-causing virus, Epstein–Barr.  These cancer risks are significant and patients should be monitored closely for signs of malignancy.

This disorder is considered a combined immunodeficiency because it includes both decreased lymphocyte numbers and defective lymphocyte function. It can also be classified as a type of autosomal recessive hyperimmunoglobulinemia E syndrome. Laboratory manifestations include progressive lymphopenia that primarily affects CD4 and CD8 T cell subsets, reduced B cell and/or NK cell counts in some patients, eosinophilia, and immunoglobulin abnormalities. Antibody responses to vaccines are frequently poor.  Loss of Dock8 protein expression can be demonstrated by diagnostic intracellular flow cytometry testing.

Once a diagnosis is made, treatment is based on an individual's clinical condition and may include medication and other strategies for managing infections, allergies, and asthma. Supportive care includes prophylactic antimicrobials, and consideration of immune globulin replacement.  Interferon alpha has been used for control of serious viral infections, such as widespread warts or herpes simplex virus. Hematopoietic stem cell transplant is curative in many primary immunodeficiencies and has successfully been used for patients with DOCK8 immunodefiency.

References

Further reading


RING finger protein 146 is a protein that in humans is encoded by the RNF146 gene.

References

Further reading

RING finger proteins


The 1952 Polish Speedway season was the 1952 season of motorcycle speedway in Poland.

Individual

Polish Individual Speedway Championship
The 1952 Individual Speedway Polish Championship was held in Wrocław on 17 August 1952.

Team

Team Speedway Polish Championship
The 1952 Team Speedway Polish Championship was the fifth edition of the Team Polish Championship.

Rules
In First League, matches were played with part two teams, without it playing it matches return.  Teams consisted of 6 drivers plus 2 reserves. The score of heat: 3–2–1–0. Mecz consisted with 9 heats. For winning game team received 2 points, lost – 0 points. The drivers from the main squad started in a match three times. The quantity of small points was added up.

Before the season it was established that only 4 full rounds would take place with the 5th round consisting of only the first 8 teams. After playing 5 rounds the first 4  teams played a "Play-Off" (Semi-Final and Final).

Ogniwo Bytom was moved to Łódź, and CWKS from Warszawa to Wrocław.

First League

Play-Offs

Medalists

References

Poland Individual
Speedway


The Independence Party, established as the Independence League, was a short-lived minor American political party sponsored by newspaper publisher and politician William Randolph Hearst in 1906. The organization was the successor to the Municipal Ownership League under whose colors Hearst had run for Mayor of New York in 1905.

After its second-place finish in a race for Governor of Massachusetts in 1907, the party set its sights on the Presidency, and held a national convention to nominate a ticket in 1908. The party garnered only 83,000 votes nationally in the 1908 election, however, and immediately dissolved as a national force.

The Independence League of New York continued to nominate candidates for office in New York state until the state election of 1914.

Establishment

In 1905, millionaire newspaper publisher William Randolph Hearst made a high-profile run for Mayor of New York City under the banner of the Municipal Ownership League. Hearst ran on a reform ticket in opposition to incumbent Tammany Hall Democrat George B. McClellan, Jr. and Republican William Mills Ivins, Sr. Hearst narrowly missed election, losing to the Democrat by fewer than 3,500 votes out of nearly 600,000 cast between the three candidates, with the New York Supreme Court ultimately deciding the matter in favor of Tammany Hall on June 30 amidst charges of electoral fraud.

In the wake of the defeat the Municipal Ownership League was replaced by a new political organization with a less socialistically oriented name: the Independence League of New York.

In 1906, Hearst again ran for political office, this time going down to defeat in the race for Governor of New York on a Democratic–Independence League fusion ticket. Despite his own loss, other members of the fusion slate were elected, including Lewis S. Chanler as lieutenant governor, John S. Whalen as Secretary of State, Martin H. Glynn as comptroller, Julius Hauser as treasurer, William S. Jackson as Attorney General, and Frederick Skene as state engineer.

Parallel Independence Leagues were active at the same time in several other states, including California and Massachusetts. In the latter, state party nominee Thomas L. Hisgen garnered a substantial number of votes in the 1907 election for governor, topping the candidate of the Democratic Party for second place. Prospects seemed bright for a new national political organization to replace the Democrats as the chief opposition party in the United States.

1908 Presidential convention
Buoyed by the promising results for Thomas Hisgen in Massachusetts, the Independence League moved to establish a national presence as the Independence Party ahead of the election of 1908 at a convention held in Chicago. The gathering was convened on July 27, 1908, in a hall bedecked with patriotic red-white-and-blue bunting and streamers.

Although Hisgen was regarded as a favorite to win nomination prior to convocation, the nominating convention's decision was not unanimous nor the nomination process without acrimony, requiring three ballots of the assembled delegates to reach an ultimate decision. The first person nominated was former Congressman Milford W. Howard of Fort Payne, Alabama, placed into consideration by a long-winded speech which drew catcalls. The Howard nomination was followed by a speech by Rev. Roland D. Sawyer of Massachusetts, who formally placed Hisgen's name into the pool of candidates. This was followed by the nomination of Georgian John Temple Graves, the editor of a Hearst newspaper.

An attempt by a Kansas delegate to put the name of Democratic Party standard bearer William Jennings Bryan into nomination was met with raucous jeering which briefly prevented the speaker from continuing. With order restored, the speaker continued in his effort to formally nominate Bryan, causing an even more fierce explosion of rage and protest, as a report in The New York Times indicates:

"A scene of riot immediately followed, several delegates attempting to reach the rostrum for the purpose of offering physical violence to the speaker. 'I intend, if I am allowed to finish, to nominate Mr. William J. Bryan,' said Mr. [J.I.] Sheppard.

"The hall broke into a wild uproar, a dozen delegates vainly struggling in the main aisle in an attempt to reach Mr. Sheppard. Canes and fists were shaken at him furiously, while howls of execration went up from all sides of the hall."

Only after an extended period of tumult was order restored and Sheppard ruled out of order on the grounds of having nominated an individual who was not a member of the Independence Party. Sheppard walked from the rostrum under protection of the convention's two sergeants of arms, but was still swung at with a cane by a New York delegate as he passed down the aisle, with the New Yorker forcibly restrained. An announcement shortly followed that Sheppard had been removed as a member of the National Committee of the Independence Party.

With the nominations finally complete, convention voting ensued. The first ballot saw a tally of 396 votes for Hisgen, 213 for Graves, 200 for Howard, 71 for Reuben R. Lyon, and 49 for William Randolph Hearst. A second ballot brought Hisgen to the doorstep of nomination, gathering 590 votes, compared to 189 for Graves and 109 for Howard. Only in the early morning hours of Wednesday, July 29 did Hisgen go over the top, winning the nomination. Graves was elected as Hisgen's Vice-Presidential running mate by the gathering.

Party platform

The party platform adopted by the Chicago convention declared that corporate corruption, waste in government spending, the exploitative pricing of monopolies, a costly tariff, and rule by political machines had exacted a costly economic toll on both investors and working people alike. Both the Republican and Democratic parties, were to blame, the Independence Party declared, and it cast itself as the banner-bearer in the effort "to wrest the conduct of public affairs from the hands of selfish interests, political tricksters, and corrupt bosses" and to make government "an agency for the common good."

The party platform argued against corrupt machine politics, for the eight-hour work day, against the use of judicial injunctions to settle labor disputes, for the creation of a Department of Labor, for improved workplace safety, and for the establishment of a central bank. The organization expressed its disapproval of maintenance of blacklists against striking workers and against the use of prison labor for the production of goods for the marketplace. The organization also favored broad implementation of the initiative and referendum system and in favor of the power of recall of elected officials.

Although mildly social democratic in content, the platform of the Independence Party took pains to cast the organization as "a conservative force in American politics, devoted to the preservation of American liberty and independence."

Final efforts

The national party collapsed after the 1908 election, in which Hisgen and Graves won less than one percent of the popular vote.

Hearst ran again for Mayor of New York in 1909, and for lieutenant governor in 1910, but was defeated both times.  The New York Independence League continued to nominate candidates for Governor and Lieutenant Governor of New York until the state election of 1914.

Footnotes

Further reading

 Ben H. Procter, William Randolph Hearst: The Early Years, 1863-1910. New York: Oxford University Press, 1998.
 Darcy Richardson, Others: Third Parties During the Populist Period. Bloomington, IN: iUniverse, 2007.
 "Independence Vacancies Filled by Democrats," New York Times, Sept. 30, 1906.

Political parties established in 1906
Political parties disestablished in 1914
Defunct political parties in the United States
Progressive Era in the United States
1906 establishments in the United States
1914 disestablishments in the United States
Political parties in the United States


La Société Expéditionnaire is a Pennsylvania-based independent record label established in 2006 by Lewis & Clarke's Lou Rogai. On previous Lewis & Clarke albums, the liner notes contained a contact address for "The Expeditionary Society", a nod to the exploratory reference of Lewis & Clarke. This phrase was also taped to the door of Rogai's studio in Delaware Water Gap, Pennsylvania. An intoxicated French Appalachian Trail through-hiker mistakenly stumbled into the practice room, thinking it was the local hostel, and exclaimed "La Société Expéditionnaire!".

The first official release was a split 7-inch record by Strand of Oaks and Dragon Turtle.

Mission

La Société Expéditionnaire is an independent record label which provides a framework of production, promotion and distribution for musicians and artists. The goal is to uncover and expose the "hidden gems" of wild, fragile and obscure music.

Artists
 Arc in Round
 Matt Bauer
 Martin Bisi
 The Black Swans
 Blessed Feathers
 Jonathan Byerley
 Judson Claiborne
 Cedar Sparks
 Columboid
 Dragon Turtle
 Goodnight Stars Goodnight Air
 Fantastic
 Daniel Knox
 Laser Background
 Lewis & Clarke
 Moon & Moon
 Mako Sica
 Lou Rogai
 Soars
 Soltero
 Strand of Oaks
 Joey Sweeney
 Tamarin
 Weatherman

References

American independent record labels


Peroxisomal acyl-coenzyme A oxidase 3 is an enzyme that in humans is encoded by the ACOX3 gene.

Acyl-Coenzyme A oxidase 3 also known as pristanoyl-CoA oxidase (ACOX3) is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in the liver such that its mRNA was undetectable by routine Northern-blot analysis, by immunoblotting for its product, or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined.

See also
 ACOX1
 Acyl-CoA oxidase

References

Further reading

External links

Human proteins


Edna Ernestine Kramer Lassar (May 11, 1902 – July 9, 1984), born Edna Ernestine Kramer, was an American mathematician and author of mathematics books.

Kramer was born in Manhattan to Jewish immigrants. She earned her B.A. summa cum laude in mathematics from Hunter College in 1922. While teaching at local high schools, she earned her M.A. in 1925 and Ph.D. in 1930 in mathematics (with a minor in physics) from Columbia University with Edward Kasner as her advisor.

She wrote The Nature and Growth of Modern Mathematics, A First Course in Educational Statistics, Mathematics Takes Wings: An Aviation Supplement to Secondary Mathematics, and The Main Stream of Mathematics.

Kramer married the French teacher Benedict Taxier Lassar on July 2, 1935. Kramer-Lassar died at the age of 82 in Manhattan of Parkinson's disease.

Works
 The Main Stream of Mathematics  (1951)
 The Nature and Growth of Modern Mathematics (1970)

References

External links
 Biography from Agnes Scott College
 MacTutor biography
  Biography on p. 335-337 of the Supplementary Material at AMS

1902 births
1984 deaths
Hunter College alumni
Columbia Graduate School of Arts and Sciences alumni
People from Manhattan
20th-century American mathematicians
American women mathematicians
Neurological disease deaths in New York (state)
Deaths from Parkinson's disease
20th-century women mathematicians
Mathematicians from New York (state)
20th-century American women


Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BE gene.

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.

The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

References

Further reading


Histone H3.1 is a protein that in humans is encoded by the HIST1H3D gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order   structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

References

Further reading


Histone H3.1 is a protein that in humans is encoded by the HIST1H3G gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order   structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

References

Further reading


Histone H4 is a protein that in humans is encoded by the HIST1H4B gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 147 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order   structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

References

Further reading


Hunderfossen Station is a railway station located at the village of Hunderfossen in Lillehammer, Norway. The station is located on the Dovre Line and served express trains to Oslo and Trondheim. The station was opened in 1986 and serves the areas of Øyer, the Hafjell skiing resort and Hunderfossen Family Park. During the 1994 Winter Olympics it served Hafjell and the Lillehammer Olympic Bobsleigh and Luge Track.

Railway stations in Oppland
Railway stations on the Dovre Line
Railway stations opened in 1986
1986 establishments in Norway
Buildings and structures in Lillehammer
Railway stations in Norway opened in the 1980s


Transcription factor SOX-14 is a protein that in humans is encoded by the SOX14 gene.

Function

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome.

References

Further reading

Transcription factors


Annexin A9 is a protein that in humans is encoded by the ANXA9 gene.

Function

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.

Model organisms
Model organisms have been used in the study of ANXA9 function. A conditional knockout mouse line called Anxa9tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed:  - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping

References

External links

Further reading


Pseudouridylate synthase 7 homolog-like protein is an enzyme that in humans is encoded by the PUS7L gene.

Model organisms

Model organisms have been used in the study of PUS7L function. A conditional knockout mouse line, called Pus7ltm2a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on homozygous mutant mice and one significant abnormality was observed: an increased susceptibility to bacterial infection.

References

Further reading

Genes mutated in mice


Plasmalemma vesicle-associated protein is a protein that in humans is encoded by the PLVAP gene.

References

Further reading


Kit Williamson (born November 13, 1985) is an American actor and filmmaker. He is known for creating, writing, directing, and starring in the dark comedy web series EastSiders. For his work on the series, he has been nominated for several Indie Series Awards and Daytime Emmy Awards.

Early life
He was born and raised in Jackson, Mississippi and attended Interlochen Arts Academy, an arts boarding school in northern lower Michigan. He later attended Fordham University and received his MFA from UCLA's School of Theater, Film and Television.

Career

EastSiders

In 2012, Williamson created the web series EastSiders; two episodes were launched on YouTube in December 2012. Williamson crowdfunded the remaining episodes on Kickstarter, raising over $25,000. The subsequent second and third seasons were also successfully crowded funded through Kickstarter. In 2014, Wolfe Video became the series official distributor. The series was sold to Netflix in 2016, and a third season was released in 2017. The series has received critical acclaim since its release.

Writing for IndieWire, Williamson explained his inspiration for the series:My goals when I created the show were simple; I wanted to write, direct and star in a project and see it through to completion, because I had been involved in so many micro budget projects that never saw the light of day. I also wanted to create the kind of LGBT series that TV networks refuse to, one where the main characters were not only gay, but flawed, complex individuals trying to navigate their messy lives, just like their straight friends.For his work on EastSiders, Williamson received a Daytime Emmy Award nomination for Outstanding Digital Daytime Drama Series, as well as several Indie Series Award nominations.

Other work
Williamson has worked as an actor on stage, television, and in film. He appeared in the Broadway premiere of Eric Bogosian's Talk Radio, starring Liev Schreiber, which ran from March 11 to June 24, 2007. Other stage performances include the Off-Broadway premiere of Przemyslaw Wojcieszek's Made in Poland. For this performance in Made in Poland, Williamson earned a positive review in Variety: "Williamson's hilariously serious perf as an angst-filled wannabe revolutionary strikes exactly the right note. As he wanders around his little town in post-Communist Poland, vandalizing cars and trashing phone booths, the unfairness of everything becomes so oppressive he delivers Bogus' every line like it's a prelude to a fistfight."

His television roles include a recurring role on the AMC series Mad Men, from 2013 to 2015, as well as supporting roles on Numb3rs (2009), Death Valley (2011), and The Good Wife (2015).

In 2021, Williamson was announced alongside Brittany Cavallaro as a writer and producer for the television adaptation of Mercedes Lackey's Valdemar novel series. The first season will adapt Lackey's Last Herald-Mage trilogy. The show is being developed by Radar Pictures with Ted Field as Executive Producer.

Williamson said that his connection the trilogy's gay protagonist enamored him with the books, telling Deadline: Vanyel in The Last Herald Mage series was one of the first gay characters I encountered, and as a recently out 16-year-old I can’t stress enough the impact that these books had on me. The Valdemar series was far ahead of its time in the portrayal of LGBTQ characters, and Lackey’s writing afforded them a level of depth and complexity that is still very rare, especially in genre storytelling.

Personal life
Williamson is openly gay and has been married to his EastSiders co-star John Halbach since February 27, 2016.

References

External links
Kit Williamson on Twitter

Living people
American directors
American male stage actors
American male television actors
American gay actors
Interlochen Center for the Arts alumni
1985 births
Fordham University alumni
University of California, Los Angeles alumni
People from Jackson, Mississippi
Actors from Mississippi


Peroxisomal NADH pyrophosphatase NUDT12 is an enzyme that in humans is encoded by the NUDT12 gene.

Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors.

Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003).[supplied by OMIM]

References

Further reading

Nudix hydrolases


Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Bcl2L12 expression is upregulated in most human glioblastomas. Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism. Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.

References

External links

Further reading


Riisu is Finnish industrial metal band Ruoska's second album; it was released on 9 September 2003. There were no music videos for this album.

Track listing
Elon tiellä ('On Life's Road') – 3:18
Puhe ('Speech') – 3:57
Darmstadt – 3:32
Kuka luopuisi kuolemastaan ('Who Would Abandon Death') – 3:41
Synkät soinnut, rujot riimit ('Dark Chords, Ugly Rhymes') – 3:22
Riisu ('Disrobe') – 3:56
Työmiehen haudalla ('On Worker's Grave') – 4:46
Rauta valittaa ('Iron Laments') – 4:00
Airut ('Herald') – 3:50
Maailmanlopun pyörä ('The Wheel of the End of the World') – 2:55
Piruparka ('Poor Sod') – 4:48

Band members
During the album recording, these were the band members:
Patrik Mennander (vocals)
Anssi Auvinen (guitar)
Kai Ahvenranta (guitar)
Mika Kamppi (bass)
Sami Karppinen (drums)

References
 Discography at Ruoska official website

External links
English fansite

Ruoska albums
2003 albums


Calcium-binding protein 8 is a protein that in humans is encoded by the CALN1 gene. Alternative splicing results in multiple transcript variants.

Function

This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites.

References

External links

Further reading

EF-hand-containing proteins


Khalifa Mohammad Asadullah (6 August 1890 – 23 November 1949) was a pioneer of the library movement in the Indian subcontinent before 1947. He was also the first prominent librarian to opt for Pakistan at the time of independence in 1947.

Early life
He was born on 6 August 1890 in Lahore, British India (now Pakistan) to Maulvi Mohammd Ziaullah and Alam Jan of Simla. He received his basic education in Lahore and graduated from Forman Christian College, Lahore in 1913.

Marriage and family
In 1908, he married Hameeda Begum in Lahore and fathered 14 children. His sons included Khalifa Mohd Iftikharullah TQA, Khalifa Mohd Naseemullah, Khalifa Mohd Hameedullah, Khalifa Mohd Ihsanullah, Khalifa Mohd Zafarullah (Commander Pak Navy), Khalifa Mohd Aminullah.  His sons-in-law included AVM Saeedullah Khan and Pakistani diplomat, Enver Murad; his daughters-in-law included Zaib-un-Nissa Hamidullah and his great granddaughters include the Pakistani novelist, Uzma Aslam Khan.

Training
He studied under the American librarian Asa Don Dickinson in 1915 at the University of the Punjab.

Career
In 1916, he became the first qualified librarian of the Government College in Lahore. He then became the librarian of MAO College (now Aligarh Muslim University) in 1919. In 1921, he joined the Imperial Secretariat Library in New Delhi and Simla, a post he held for 8 years.

In 1930, he was appointed the Librarian of the Imperial Library (now National Library of India) in Calcutta, a post which he held for about 17 years from 1930 – 1947. While there, he started the library training programme.

Pakistan
In 1947, after the independence of Pakistan, he was made officer on special duty in the Ministry of Education.

Indian Library Association
In 1933, he was one of the founding members of Indian Library Association and was its first Secretary from 1933 to 1947. He had served as the Librarian and a Director from 1930 – 1947 of the Imperial Library of India in British India.

Honours
He was honoured with the title of Khan Bahadur in  1935.

Death
He died on 23 November 1949 due to a stroke at Lahore, Pakistan. He was buried in his family section of the Ferozpur Road graveyard, Lahore.

References

Pakistani librarians
Indian librarians
People from Lahore
People from Shimla
1890 births
1949 deaths
Academic staff of the Government College University, Lahore
Forman Christian College alumni


Nuclear receptor-interacting protein 2 is a protein that in humans is encoded by the NRIP2 gene.

References

Further reading


Cysteine-rich secretory protein LCCL domain-containing 2 is a cysteine-rich secretory protein that in humans is encoded by the CRISPLD2 gene.

It has been predicted or experimentally observed to interact with C1orf173.

References

External links

Further reading

Extracellular matrix proteins


Serine/threonine-protein kinase 40 is an enzyme that in humans is encoded by the STK40 gene.

References

Further reading

EC 2.7.11