Anthony Tyson Jackson (born June 6, 1986) is a former American football defensive end. He was drafted by the Kansas City Chiefs with the third overall pick in the 2009 NFL Draft. He played college football at LSU.

Early years
Jackson attended West St. John High School in Edgard, Louisiana where he was a member of the Rams 2003 and 2004 2A State Championship teams. He was a two-way lineman who was named Class 2A Defensive Player of the Year after a senior season that totalled 84 tackles, 16 sacks, and 17 pressures, while winning the state championship. He was named All-District and All-Parish on the gridiron and also lettered in basketball. Considered a three-star recruit by Rivals.com, Jackson chose LSU over Oklahoma State and Colorado.

College career
Jackson redshirted for the Tigers in 2004.

As a redshirt freshman in 2005, he earned a spot on the Freshman All-SEC team by the league's coaches and the Sporting News. He recorded thirteen tackles (8 solos) and two sacks and added five quarterback pressures.

As a sophomore, in 2006, Jackson was a Second-team All-SEC selection. He was a starter at left defensive end and recorded 37 tackles (13 solos). He also had 8.5 sacks, six pressures and 10.5 tackles for a loss. Jackson caused and recovered a fumble, broke up four passes and caught an interception.

As a junior, in 2007, Jackson started thirteen of fourteen games at left defensive end. He totalled 36 tackles (15 solos) with 3.5 sacks, 4.5 stops for losses, and twelve quarterback pressures. Jackson caused a fumble and ranked second in the NCAA among defensive linemen with ten pass break-ups.

As a senior, in 2008, Jackson earned All-SEC Second-team again. He recorded 36 tackles (17 solos) that included 4.5 sacks, 10.5 stops for losses, and seven quarterback pressures. He recovered a fumble and deflected four passes. In total, Jackson started 38 of 53 games at LSU, recording 122 tackles (53 solos) with 18 pass deflections, one interception, two forced fumbles, and a pair of fumble recoveries. He ranks eighth in school history with 18.5 sacks and is eleventh with 27 stops for losses.

Professional career

2009 NFL Draft
Although having played in a 4–3 alignment at Louisiana State, Jackson was considered an ideal 3–4 defensive end.  He drew comparisons to Anthony Weaver.  Jackson was chosen by the Kansas City Chiefs in the first round with the third pick overall.

Kansas City Chiefs

Jackson was drafted in the first round with the third overall selection by the Chiefs, who looked to implement him as defensive end into their new 3-4 defense. Jackson remained unsigned at the beginning of the Chiefs' training camp session and did not travel with the team to River Falls, Wisconsin (site of the team's practice facilities). The holdout ended on August 7 as he was signed to a five-year contract reportedly worth $57 million with $31 million guaranteed.
Tyson played in all 16 games of his rookie season and had 38 tackles (27 solo) with two pass deflections. In 2010, he recorded 31 total tackles and one sack. In 2011, Jackson had only one sack though he also had a career record of 55 tackles.

Atlanta Falcons
On March 11, 2014, Jackson signed a five-year $25 million deal with the Atlanta Falcons.

In the 2016 season, Jackson and the Falcons reached Super Bowl LI, where they faced the New England Patriots on February 5, 2017. In the Super Bowl, Jackson had one total tackle as the Falcons fell in a 34–28 overtime defeat.

On March 9, 2017, Jackson was released by the Falcons.

NFL statistics

References

External links
Atlanta Falcons bio
Kansas City Chiefs bio

1986 births
American football defensive ends
Atlanta Falcons players
Kansas City Chiefs players
Living people
LSU Tigers football players
People from Edgard, Louisiana
Players of American football from New Orleans


Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.

CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells . [supplied by OMIM]

Clinical significance
Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.

References

External links

Further reading


E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene. It is a member of the MARCH family of E3 ligases, and plays an important role in the turnover of membrane proteins. MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial infections.

Gene name error in Excel

Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH2 gene in Microsoft Excel. This is due to Excel's autocorrect feature treating the MARCH gene as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error. The issue can be prevented by using an alias name such as MARCHF2, prepending with an apostrophe ('), or preformatting the cell as text.

References

Further reading


Ibanda is a town in the Western Region of Uganda. It is the main political, administrative, and commercial centre of Ibanda District and the site of the district headquarters. It started wayback in 1990s and was elevated from a trading centre to a town board, town council and in 2016 it was granted a Municipality status. The Municipal Council has three Divisions of Kagongo, Bisheshe and Bufunda with 21 wards of Kyaruhanga, Bufunda, Nyamirima, Nsasi, Kayenje, Kashangura, Rwenshuri, Kigarama, Rugazi, Rwobuzizi, Kakatsi, Bugarama, Karangara, Kabaare, Kanyansheko, Nyakatookye, Kyeikucu, Kikoni, Kagongo, Ruyonza and Katongore ward. Ibanda Municipal Council has over 230 villages.
Ibanda Municipal council commenced its operations on 1 July 2016 after being elevated from a Town Council and other sub counties that were annexed to. (Bisheshe Sub County, Nsasi, Part of Nyabuhikye Sub County and Kashangura).

Location
Ibanda is located approximately , by road, northwest of Mbarara, the largest city in the Ankole sub-region. This is about , by road, southwest of Kampala, the capital of and largest city in Uganda. The coordinates of the town are 0°08'05.0"S, 30°29'42.0"E (Latitude:-0.134712; Longitude:30.495000).

Ibanda Municipal Council is located in Ibanda South Constituency of Ibanda District, south western part of Uganda. It borders with Igorora Town Council, Kikyenkye, Kijongo and Ishongororo sub-counties of Ibanda District, Kinoni s/c in Kiruhura District and Kicheche Sub-County of Kamwenge district and it hosts the Ibanda District headquarters. The total geographical area of the council is about , both dry land (built environment and open land) wetlands and open water area.
The former town council started back in 1994 with two wards of Bufunda and Kagongo and during the physical development plan process in 2010, three more wards were created i.e. Rugazi, Kigarama and Kyaruhanga, covering a total area of .

History
Ibanda is known for the killing of Harry George Galt, a British sub-commissioner for the western province of the Uganda Protectorate, on 19 May 1905.
Its name came from a native word Ibandwa where the local people used to climb the hill to settle their misfortunes with their gods hence translated as ibandwa hill.

Population
The 2002 national census estimated the population of Ibanda at 22,730. In 2010, the Uganda Bureau of Statistics (UBOS) estimated the population at 27,800. In 2011, UBOS estimated the mid-year population at 28,500. In 2014, the national population census put the population at 31,316.

Points of interest
The following additional points of interest lie in Ibanda town or close to its borders:
 offices of Ibanda Town Council
 the headquarters of Ibanda District Administration
 Ibanda University, a private co-educational institution of higher learning, established in 2014.
 Uganda Martyrs' Hospital Ibanda,  a community hospital administered by the Roman Catholic Archdiocese of Mbarara

Photos
Another View of Ibanda Town

See also
 Patrick Bitature
 List of cities and towns in Uganda

References

External links
Google Map of Ibanda Town

Ibanda District
Ankole sub-region
Populated places in Western Region, Uganda


Michał Sokolnicki (1760, in Wierzeja – 1816, in Warsaw) was a Polish nobleman (of Nowina coat of arms), general, military engineer, politician, and writer.

Sokolnicki studied in Warsaw's Corps of Cadets and fought in the Polish–Russian War of 1792 as well as the Kościuszko Uprising of 1794. In 1797 he presented the French Directory with a document entitled "Aperçu sur la Russie". This became known as the so-called "Testament of Peter the Great", which Napoleon Bonaparte used for anti-Russian propaganda purposes in 1812, and has been widely publicised since, although scholars have since established that the document is a forgery.

From 1797 on, Sokolnicki was a member of the  Danube Legion and later of the Polish Legions in France under Napoleon. After 1808, he was a general in the army of the Duchy of Warsaw and took part in the Polish–Austrian War, where he was instrumental in defeating the Austrians in two major battles. Sokolnicki then took part in Napoleon's invasion of Russia. After Napoleon's defeat and the Duchy's occupation by Russia, he removed himself from public life and died in an accident in 1816.

Sokolnicki was awarded the Officer's Cross of the Legion of Honour (12 August) and the Commander's Cross of the Virtuti Militari (22 August 1809).

References

External links
The Will of Peter the Great / Testament of Peter the Great

1760 births
1816 deaths
People from Szamotuły County
Generals of the Polish–Lithuanian Commonwealth
Officers of the Legion of Honour
Commanders of the Virtuti Militari
Polish generals
People of the Polish–Russian War of 1792
Polish commanders of the Napoleonic Wars


The Roman Catholic Diocese of Maradi () is a diocese located in Maradi in Niger.  It is a suffragan in the province which includes the metropolitan archdiocese of Niamey.

History
 March 13, 2001: Established as Diocese of Maradi from Diocese of Niamey

Leadership
 Bishops of Maradi (Roman rite)
 Bishop Ambroise Ouédraogo (since March 13, 2001)

See also
Roman Catholicism in Niger

Sources
 GCatholic.org
 Catholic Hierarchy

Roman Catholic dioceses in Niger
Christian organizations established in 2001
Roman Catholic dioceses and prelatures established in the 21st century
2001 establishments in Niger
Maradi, Niger


C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

References

External links

Further reading

C-type lectins


Chemilly may refer to the following places in France:

 Chemilly, Allier, a commune in the department of Allier
 Chemilly, Haute-Saône, a commune in the department of Haute-Saône
 Chemilly-sur-Serein, a commune in the department of Yonne
 Chemilly-sur-Yonne, a commune in the department of Yonne


Chemilly () is a commune in the Allier department in central France.

Population

See also
Communes of the Allier department

References

Communes of Allier
Allier communes articles needing translation from French Wikipedia


Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.

Structure

KLF3, originally termed Basic Krüppel-like Factor (BKLF), was the third member of the Krüppel-like factor family of zinc finger transcription factors to be discovered. Transcription factors in this family bind DNA by virtue of 3 characteristic three C2H2 zinc fingers at their C-termini. Since their DNA-binding domains are highly conserved within the family, all KLF proteins recognize CACCC or CGCCC boxes of the general form NCR CRC CCN, (where N is any base and R is a purine).

Function

While the C-termini are similar in different KLFs, the N-termini vary and accordingly different KLFs can either activate or repress transcription or both. KLF3 appears to function predominantly as a repressor of transcription. It turns genes off. It does this by recruiting the C-terminal Binding Protein co-repressors CTBP1 and CTBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, of the general form Proline – Isoleucine – Aspartate – Leucine – Serine (the PIDLS motif). CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression.

KLF3 is expressed highly in the red blood cell or erythroid lineage. Here it is driven by another KLF, Erythroid KLF or KLF1, and its expression increases as erythroid cells mature. Studies in knockout mice reveal a mild anemia in the absence of functional KLF3 and the de-repression of several target genes that contain CACCC boxes in their regulatory regions. Many of these genes are activated by KLF1, hence it appears that KLF3 operates in a negative feedback loop to balance the activating potential of KLF1. KLF3 also regulates another repressive KLF, KLF8. Thus KLF1, KLF3 and KLF8 operate in a tight regulatory network. KLF3 and KLF8 may have redundant functions, as mice lacking both KLF3 and KLF8 show defects that are more severe than in either single knockout. They die in utero around day 14 of gestation.

As well as being expressed in erythroid cells, KLF3 is present in other cell types and analysis of the knockout mice has revealed defects affecting adipose tissue and B cells. KLF3 deficient mice have less adipose tissue and indications of metabolic health that may be attributable to de-repression of the adipokine hormone gene adipolin. The role of KLF3 in B lymphocytes is complex but it appears to operate in a network with KLF2 and KLF4 to influence the switch between spleen marginal zone and follicular B cells.

Interactions
KLF3 has been shown to interact with:
 CTBP2 and
 FHL3.

References

Further reading

External links

Transcription factors


Franco and Afro Musica is a twelve piece kwasa kwasa band from Gabane, Botswana.

The band was founded by Frank "Franco" Lesokwane. As is the norm in the soukous (Congolese rumba) circles for artists to go by more than one names, Lesokwane also goes by several other names like Stango, Molamu, Lepako and Chakala. After playing and providing vocals for other leading Kwasa kwasa bands in Botswana, Franco, together with Tanzanian born lead guitarist, Shabani Mwanasande Yohana, formed the band and started touring the country. They recruited other soukous experts and recorded their first album, Ke lela le lona, which loosely translates to "I am crying with you". Other members of Afro Musica are DannyBass Dikole Gasebatho (bass guitar), Oxy Oxygen Ntoko (Drum), Samurai Ngingo (lead guitar).

After Ke lela le lona the band has produced albums annually. The band released their most popular single Tshutshumakgala (a tswana name for a train), which won them their first Botswana Music Union (BOMU) Award. This is a song about how much they fear the train. The songs are usually about controversial issues in the society like witchcraft, promiscuity and death. They tend to write material that is very personal and in each album, the band has at least one song that tells a story about a certain village in Botswana, which has earned them a good following. The band has won several awards, including the BOMU "Best Kwasa Kwasa Album of the Year" two years in a row.

However, in his first ever music video for his new album Mmamane Robala, Lesokwane, does not feature his back-up band or dancers, especially in interviews and behind the scene footage and he is unapologetic about it. "I gave them publicity on my cassette and CDs, what more do people want. I have written about those guys on my album sleeves. " I do not think it was so important to feature them in the video," said Franco, when asked why the band did not receive the same exposure he gave himself in the video. "We did not see it necessary to do so. People will talk as they always do, but it is up to the management to decide these things. Maybe Afro Musica will appear in the next video.

In April 2005, the band supported Koffi Olomide in his African tour. Koffi was quoted as saying "I am shocked to learn that the standards of the rhumba music in the country are this high."

Discography
Ke lela le lona (2001)
Ba ntatola (2002)
Robala Nnana (2003)
O nyala leng (2004)
Mmamane Robala (2005)
Khutsanyana (2006)
Spekere (2007)
Koti Koti (2008)
Baesekele (2009)
sephiri se dule (2011)
maja ka thata (2012)
Ke Fela Pelo (2013)
Ke lorile sengwe (2014)
Zeng zeng ke eng (2015)
Eya le nna Babilone (2017)
Mene Mene Tekele (2018)

Awards
 Best kwasa kwasa album of the year (2 years in a row).

References
http://www.mmegi.bw/2007/October/Monday15/87.php
http://www.bloggersmusic.com/2007/10/27/the-lesokwanes-take-rhumba-music-scene-by-storm/

Botswana musical groups
Soukous groups


BingoLotto is a hybrid lottery-bingo style gameshow based on the Swedish show of the same name, Bingolotto. Each week, viewers with a valid gamecard had a 1 in 9.5 chance of winning. However, unlike the National Lottery, prizes would be life-enhancing, rather than life-changing. In other words, prizes were "small," varying from more game-cards to the maximum cash prize of £100,000. The game cards were printed in Sweden by "Idrottens Digital Print".

The show was promoted by IGS Television, as often mentioned in broadcasts.

The Game

Card Spins
Every Game-card had a serial number unique to that card. During each show, numbers would spin on screen. If a person sitting at home could match their serial number to those on screen, they could call in an receive a prize. Prizes ranged from digital cameras to cars.

Bingo Games
There were 3 Bingo games that took place in BingoLotto. They corresponded with the red, yellow, and blue "cards" that were on each BingoLotto game-card. As numbers were read out on the show, players at home (and in the studio) would cross out corresponding numbers on the card. If a player got 4 corners or a straight line, they had a chance to call the studio and win a prize.

Cancellation
The company behind Bingolotto UK was reported to be in liquidation as of 8 October 2009. Employees were let go, and a year later, on Sunday 4 October 2009, ran the last BingoLotton Game in the UK.

Music
Presentation elements of the main show were intertwined with various musical interludes including the acclaimed "Get me to the Church on time" theme.

Beneficiaries
Like competing lotteries, Bingolotto donated some of its proceeds to charity. For example, at least 20% made from the sale of the £2 BingoLotto cards was donated to two charities: the CCPR and the NCVO.

CCPR

CCPR is the national alliance of governing and representative bodies of sport and recreation.

NCVO

The National Council for Voluntary Organisations (NCVO) is the umbrella body for the voluntary sector in England. NCVO works to support the voluntary sector and to create an environment in which voluntary organisations can flourish.

Trivia

 The show's mascot was Mr. Bing, the bingo card, born at 7.07 pm on 7 July 1977. He weighed 7lb, 7oz.
 The show ran without commercial breaks.

See also
Bingolotto (Swedish version).
National Lottery
The Health Lottery

References

External links
BingoLotto.tv

2000s British game shows
2008 British television series debuts
2009 British television series endings
Channel One (British and Irish TV channel) original programming


The 101st Field Artillery ("Boston Light Artillery") regiment is the oldest field artillery regiment in the United States Army with a lineage dating to 13 December 1636 when it was organized as the South Regiment. It is one of several National Guard units with colonial roots and campaign credit for the War of 1812. For the first 250 years of the unit's existence it served in infantry formations.

History
101st Field Artillery Regiment was first formed on 13 December 1636 as the South Regiment by the Massachusetts General Court. Its first commander was Colonel John Winthrop. Since its creation, the regiment has served in six colonial wars and nine American wars totalling 47 campaigns through 2010.

In addition to its own lineage, the 101st Field Artillery Regiment holds the lineage of the 180th Field Artillery Regiment, the 211th Field Artillery Regiment, the 241st Field Artillery Regiment and the 272nd Field Artillery Battalion. Battery C, 1st Battalion 101st Field Artillery holds the lineage of the 102nd Field Artillery and the Second Corps of Cadets.

Recent and current organization
The regiment currently consists of the Headquarters and Headquarters Battery, 1st Battalion, 101st Field Artillery Regiment based in Brockton, Massachusetts and an inactive Battery E, 101st Field Artillery, formerly based in Rehoboth, Massachusetts. Both units are in the Massachusetts National Guard.

Battery A, 1st Battalion, 101st Field Artillery is based in Fall River, Massachusetts. Battery B is based in Waterbury, Vermont and is part of the Vermont National Guard. Battery C, 1st Battalion 101st Field Artillery, re-activated in 2016, is based in Danvers, Massachusetts.

As part of ongoing reorganizations, the 1st Battalion, 101st Field Artillery has been part of the 26th Infantry Division Artillery (1975–1993), the 42nd Infantry Division Artillery (1993–2003), the 29th Infantry Division Artillery (2003- 2006?) and the 26th Infantry Brigade Combat Team (2006? - 2009?). Since 2009(?), the battalion has been assigned to the 86th Infantry Brigade Combat Team (IBCT), and in 2016 the 86th IBCT was reorganized under the 10th Mountain Division as part of the Army's Associated Units Program.

Battery E, 101st FA served as a target acquisition battery in the 26th Infantry Division Artillery, the 42nd Infantry Division Artillery, and the 197th Field Artillery Brigade. Battery E inactivated in (??) as part of force reductions.

Recent Overseas Actions

 In July 2021, Headquarters and Headquarters Battery, 1st Battalion, 101st Field Artillery Regiment deployed to the Hamid Karzai International Airport in Kabul, Afghanistan as part of the defense (C-RAM) and retrograde of all remaining U.S. forces from Afghanistan and was part of the international humanitarian effort to evacuate Afghani civilians from Kabul, remaining on ground until 11:58 pm on August 30st, 2021 (2021 Kabul airlift).

Notable non-combat actions

 In August 1765, the regiment was activated to patrol the streets of Boston to help quell riots that broke out in response to the Stamp Act.(241st FA Regiment Lineage).
 In March 1770, elements of the regiment again patrolled the streets of Boston to enforce the law after the Boston Massacre.(241st FA Regiment Lineage).
 In 1786 during Shays' Rebellion, members of the regiment protected judges and the Taunton courthouse after it was surrounded by insurgents. (211th FA Lineage)
 Between July and October 1863, the regiment served in New York City to enforce draft laws after the New York Draft Riots (241st FA Regiment Lineage).
 The regiment was called into state service on 14 July 1863 during the Boston Draft riots (101st FA Regiment lineage). While manning the Cooper Street Armory in Boston's North End, the armory was attacked by over 1,000 rioters intent upon seizing the weapons stored there.  When the mob penetrated the armory's main gate, the soldiers opened fire killing and wounding dozens of rioters, effectively ending the attack.
 The regiment was reviewed by President Andrew Johnson in 1867, President Ulysses S. Grant in 1869 and President Chester A. Arthur in 1882.(241st FA Regiment Lineage).
 The regiment took part in the funeral of President Ulysses S. Grant in 1885.(241st FA Regiment Lineage).
 From 16 June to 27 November 1916, the regiment was federalized and served in Texas during the Mexican Border crises (101st FA Regiment lineage – also see Pancho Villa Expedition).
 In May 1996, Detachment 1, Headquarters Battery, 101st Field Artillery Battalion was ordered to active duty to serve with the Nordic-Polish Brigade in Bosnia in support of Operation Joint Endeavor.
 In May 1997, Echo Battery, 101st Field Artillery (TAB) was activated and served throughout Bosnia in support of Operation Joint Guard.
 After the terrorist attacks on 11 September 2001, members of the 1st Battalion 101st Field Artillery served on state orders protecting the Pilgrim Nuclear Power Plant and the Massachusetts Military Reservation at Camp Edwards.
 Select soldiers served as part of a joint operations task force providing security for the 2002 Olympic Winter Games in Salt Lake City, Utah
 The regiments howitzers fire blank rounds each Fourth of July during the Boston Pops Orchestra's playing of the 1812 Overture. It also provides howitzers to fire during a Fourth of July concert in Plymouth, Massachusetts.
 On the first Monday in June, the regiment provides a howitzer salute as part of the Ancient and Honorable Artillery Company of Massachusetts' June day drumhead election reenactment ceremony which is held on Boston Common close to the Massachusetts State House.

Notable members
 Colonel John Winthrop – First commander, South Regiment
 Captain John Underhill – First full-time training officer, Commander Boston Company
 Captain Myles Standish – First commander Plymouth Company (211th FA Lineage)
 Colonel Robert Cowden – Regimental commander who organized the unit as a three-year volunteer regiment for the Civil War.
 Corporal Nathaniel M. Allen – Was awarded the Medal of Honor for saving the regimental colors from capture during the Battle of Gettysburg.
 Major Asa M. Cook – first commander Light Artillery Company, 1st Brigade. Served in American Civil War.
 Sergeant Michael J. Kelley – While serving with Echo Battery, 101st Field Artillery (TAB) at Camp Salerno, Afghanistan was killed in action on 8 June 2005 after the helicopter landing zone he was working at was hit by rocket fire. He was the first Massachusetts National Guardsman killed in action after the terrorist attacks on 11 September 2001.
 Private Walter Brennan, three-time Academy Award-winning actor, served with the 101st in France in World War I.
 Ernest R. Redmond, United States Army officer who served with the 101st Field Artillery in World War I and was later Chief of the National Guard Bureau
 Sergeant Robert J. Barrett - While serving with Alpha Battery, 1st Battalion, 101st Field Artillery in Kabul, Afghanistan was killed in action on 19 April 2010.  SGT Barrett was posthumously awarded the Bronze Star Medal and Purple Heart Medal.

See also
 Yankee Division
 Rainbow Division
 29th Infantry Division

References

External links
 Massachusetts National Guard Home Page
 1st Battalion – 101st Field Artillery Regiment, Global Security.org

Military units and formations in Massachusetts
1636 establishments in the Thirteen Colonies
Field artillery regiments of the United States Army
Field artillery regiments of the United States Army National Guard
Military units and formations established in 1636


High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene. Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.

References

Further reading

PAS-domain-containing proteins


Chézy () is a commune in the Allier department in central France.

Population

See also
Communes of the Allier department

References

Communes of Allier
Allier communes articles needing translation from French Wikipedia


Michel Mongeau (February 9, 1965 – May 22, 2010) was a Canadian professional ice hockey player. Mongeau was born in Nuns' Island, Quebec.

Biography
As a youth, Mongeau played in the 1977 and 1978 Quebec International Pee-Wee Hockey Tournaments with a minor ice hockey team from Verdun, Quebec.

He played 54 games in the National Hockey League: 50 with the St. Louis Blues and four with the Tampa Bay Lightning. He died May 22, 2010, from cancer.

Career statistics

Regular season and playoffs

References

External links

1965 births
2010 deaths
Asiago Hockey 1935 players
EHC Biel players
Canadian ice hockey centres
Cornwall Aces players
Detroit Vipers players
Diables Noirs de Tours players
Flint Spirits players
Halifax Citadels players
Laval Titan players
Laval Voisins players
Manitoba Moose (IHL) players
Milwaukee Admirals (IHL) players
Ice hockey people from Montreal
Peoria Rivermen (IHL) players
Phoenix Roadrunners (IHL) players
Quebec Rafales players
Saginaw Generals players
St. Louis Blues players
Tampa Bay Lightning players
Undrafted National Hockey League players


Colombier () is a commune in the Allier department in central France.

Population

See also
Communes of the Allier department

References

Communes of Allier
Allier communes articles needing translation from French Wikipedia


6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

References

Further reading


The Andrew Gemant Award is a prize awarded by the American Institute of Physics to a person who has made substantial cultural, artistic, or humanistic contributions to physics.  The award is named after Andrew Gemant, a pioneer in materials science.

Award winners

See also
 List of physics awards

References

Awards of the American Institute of Physics
Science communication awards
Awards established in 1987


The Nite Life is an Australian Christian pop radio program on the Life FM network. Like Neighbours, many of the notable Christian personalities in Australia originate from that show. The show is of talk back format, and consists of different radio jocks every night of the week. The show simulcasts the Hot 25 Countdown on Friday as most listeners are at youth group.

Hosts
The show was formally hosted by the radio jock Kate Collins, who has since moved to Channel Nine.  The biggest competitors are the Hot 30 Countdown and the Nova 9's.

Monday - Brad, Ben, Jayne, Amie, Haydn
Tuesday - KJ - Pomfus
Wednesday - Joel - Josh - Seth - Sedrick Sockington
Thursday - Chloe - Bek - Carol - Bec (Mercy Ministries)

See also
Hot 30 Countdown
Nova 9's

Christian rock radio programs
Australian music radio programs


Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.

Function

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.

References

Further reading

External links
 The MEROPS online database for peptidases and their inhibitors: I04.026


Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no effect on cell migration or growth.

References

Further reading


Mitoferrin-1 (Mfrn1) is a 38 kDa protein that is encoded by the SLC25A37 gene in humans. It is a member of the Mitochondrial carrier (MC) Superfamily, however, its metal cargo makes it distinct from other members of this family. Mfrn1 plays a key role in mitochondrial iron homeostasis as an iron transporter, importing ferrous iron from the intermembrane space of the mitochondria to the mitochondrial matrix for the biosynthesis of heme groups and Fe-S clusters. This process is tightly regulated, given the redox potential of Mitoferrin's iron cargo. Mfrn1 is paralogous to Mitoferrin-2 (Mfrn2), a 39 kDa protein encoded by the SLC25A28 gene in humans. Mfrn1 is highly expressed in differentiating erythroid cells and in other tissues at low levels, while Mfrn2 is expressed ubiquitously in non-erythroid tissues.

Function
The molecular details of iron trafficking for heme and Iron-sulfur cluster synthesis are still unclear, however, Mitoferrin-1 has been shown to form oligomeric complexes with the ATP-binding cassette transporter ABCB10 and Ferrochelatase (or protoporphyrin ferrochelatase). Furthermore, ABC10 binding enhances the stability and functionality of Mfrn1, suggesting that transcriptional and post-translational mechanisms further regulate cellular and mitochondrial iron homeostasis.
Recombinant Mfrn1 in vitro has micromolar affinity for the following first-row transition metals: iron (II), manganese (II), cobalt (II), and nickel (II). Mfrn1 iron transport was reconstituted in proteoliposomes, where the protein was also able to transport manganese, cobalt, copper, and zinc, yet it discriminated against nickel, despite the aforementioned affinity. Notably, Mfrn1 appears to transport free iron ions as opposed to any sort of chelated iron complex. Additionally, Mfrn1 selects against divalent alkali ions.
Mfrn1 and its paralog Mfrn2 have complementary functionalities, though the precise relationship is still uncertain. For example, heme production is restored by expression of Mfrn2 in cells silenced for Mfrn1 and by ectopic expression of Mfrn1 in nonerythroid cells silenced for Mfrn2, where Mfrn1 accumulates due to an increased protein half-life. In contrast, ectopic expression of Mfrn2 failed to restore heme product in erythroid cells silenced for Mfrn1 because Mfrn2 was unable to accumulate in mitochondria.

Clinical Significance
Mitoferrin-1 has been implicated in diseases associated with defective iron homeostasis, resulting in iron or porphyrin imbalances. Abnormal Mfrn1 expression, for example, may contribute to Erythropoietic protoporphyria, a porphyrin disease linked to mutations in the Ferrochelatase enzyme. Selective deletion of Mfrn1 in adult mice led to severe anemia rather than porphyria likely because Iron-responsive element-binding protein (specifically IRE-BP1) transcriptionally regulates porphyrin biogenesis, inhibiting it in the absence of Mfrn1.
Mfrn1 has also been implicated in depression and Myelin Displastic syndrome.

Animal Studies
The importance of Mitoferrins in heme and Fe-S cluster biosynthesis was first discovered in the anemic zebrafish mutant frascati. Studies in mice revealed that total deletion of Mfrn1 resulted in embryonic lethality, while selective deletion in adults caused severe anemia as stated above. Expression mouse Mfrn1 rescued knockout zebrafish, indicating that the gene is highly evolutionarily conserved. The transcription factor, GATA-1, directly regulates Mfrn1 expression in zebrafish via distal cis-regulatory Mfrn1 elements. In C. elegans, reduced Mfrn1 expression results in abnormal development and increased lifespans of roughly 50-80%.

See also
 Solute carrier family

References

Further reading

Solute carrier family


Maspardin is a protein that in humans is encoded by the SPG21 gene.

The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4.

Interactions
SPG21 has been shown to interact with CD4.

References

Further reading


Coulanges may refer to the following:

Individuals:
 Numa Denis Fustel de Coulanges, French historian

Places in France:

 Coulanges, Allier, a commune in the department of Allier
 Coulanges, Loir-et-Cher, a commune in the department of Loir-et-Cher
 Coulanges-la-Vineuse, a commune in the department of Yonne
 Coulanges-sur-Yonne, a commune in the department of Yonne
 Coulanges-lès-Nevers, a commune in the department of Nièvre


28S ribosomal protein S17, mitochondrial is a protein that in humans is encoded by the MRPS17 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq.

References

Further reading

Ribosomal proteins


Coulanges () is a commune in the Allier department in central France.

Population

See also
Communes of the Allier department

References

Communes of Allier
Allier communes articles needing translation from French Wikipedia


George "Duke" Robinson (born October 10, 1986) is a former American football guard. Robinson played college football for the University of Oklahoma, and was recognized as an All-American twice.  He was selected by the Carolina Panthers in the fifth round of the 2009 NFL Draft.

Early years
Robinson was born in Atlanta, Georgia.  He played high school football at Washington High School in Atlanta.

College career
Robinson attended the University of Oklahoma, where he played for coach Bob Stoops's Oklahoma Sooners football team from 2005 to 2008.  He was recognized as a consensus first-team All-American a junior in 2007, becoming Oklahoma's 143rd All-American,
 and again as a senior in 2008.  He was also a two-time first-team All-Big 12 selection.  Sports Illustrated magazine named him to its All-Decade Team in 2009.

Professional career

2009 NFL Draft
Robinson was considered the number one guard prospect by many NFL scouting analyst and projected to go 2nd round of the draft until a poor performance in the BCS championship game prior to the draft.
He was praised for his leadership, his ability to pass protect and be a force in the running game.

Carolina Panthers
Duke was selected in the fifth round of the 2009 draft with the 163rd overall pick by the Carolina Panthers.

Tennessee Titans
Duke Robinson was signed to the Titans on January 6, 2012. He was then released on April 20, 2012.

Utah Blaze
Duke signed with the Utah Blaze of the Arena Football League on May 6, 2013.

Spokane Shock
Robinson was assigned to the Spokane Shock after the AFL dispersal draft on September 6, 2013.

Philadelphia Soul
On May 28, 2014, Robinson was traded by the Shock to the Philadelphia Soul for Fred Shaw.

San Jose SaberCats
On June 2, 2014, Robinson was traded to the San Jose SaberCats for Julius Williams.

Jacksonville Sharks
On March 21, 2016, Robinson was assigned to the Jacksonville Sharks.

Portland Steel
On April 25, 2016, Robinson was traded to the Portland Steel for Jamar Howard.

Personal life
He is the grandnephew of singer/songwriter Smokey Robinson.

References

External links

Oklahoma Sooners bio

1986 births
Living people
All-American college football players
American football offensive linemen
American football offensive guards
Carolina Panthers players
Oklahoma Sooners football players
Players of American football from Atlanta
Tennessee Titans players
Utah Blaze players
Spokane Shock players
Philadelphia Soul players
San Jose SaberCats players
Jacksonville Sharks players
Portland Steel players


USRC General Green was one of the first ten cutters operated by the U.S. Revenue Cutter Service. She was named for the Revolutionary War hero Major General Nathanael Greene. Her name was misspelled, probably by the man who oversaw her construction, the Collector of Customs in Philadelphia, Sharp Delany. Apparently the cutter was to have been originally named for the Secretary of the Treasury, Alexander Hamilton, but Delany changed the name for reasons unknown.

Operational history
There is little or no information on her original design and unfortunately her monthly journals have not survived but some correspondence regarding her has, particularly the exchange of letters between her master, James Montgomery, and Delany.  Indeed, there is a letter dated 23 July 1791 from the collector at Boston, Benjamin Lincoln, to Hamilton that states General Green left Adam Foulk's wharf in Philadelphia, completely outfitted, on 7 July of that year, making her one of the first of the cutters to actually enter into service.  Isaac Roach was appointed as the first mate and Benjamin Rue was appointed as the second mate on 21 March 1791.

Montgomery was the commanding officer of the Collector's barge in Philadelphia and so had some experience in revenue work prior to his commission as the master of the new cutter.  He had also seen service during the Revolution as an officer in the Pennsylvania State Navy and later saw action as the commanding officer of a privateer.

General Green had an active career patrolling the waters off Philadelphia and carrying out the federal laws of the land as instituted during President George Washington's administration.  When Great Britain and France went to war in 1793, Washington declared the neutrality of the United States and the cutters acted as the government's law enforcement arm at sea.  Her most exciting mission was undoubtedly when she was ordered to seize the French privateer Les Jumeaux, which was outfitting in Philadelphia, in direct violation of the neutrality laws.  The privateer got underway in December 1794 and General Green overtook her 40 miles off Wilmington, Delaware.  The Deputy Collector, Robinett, sailed on board the cutter and was in overall command of this seizure.

General Green was sold in 1798 to William Moodie of Philadelphia.

Commanding officers

James Montgomery, Master; 21 March 1791-1797

Notes

Citations

References cited
 General Green, U.S. Coast Guard Historian's Office website.

  No ISBN
 Kern, Florence, 1977: "A Boat in Our Bay": James Montgomery's U.S. Revenue Cutter General Green, 1791-1797, Washington, DC: Alised Enterprises.

First ten Revenue Service cutters
1791 ships


Apoptosis-related protein 3 is a protein that in humans is encoded by the ATRAID gene.

This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

References

External links

Further reading


Richard Bruce Faulds MBE (born 16 March 1977 in Guildford, Surrey), is a retired English sport shooter, who competed for Great Britain in the 2000 Summer Olympics and won the men's double trap.  He also competed at the 1996, 2004, 2008 and 2012 Summer Olympics.

Born into a family who then ran a stud farm in Sussex, Faulds was then raised on the  family-owned Owl's Lodge Farm in the Hampshire village of Longparish. On his tenth birthday, Faulds's father Bruce bought him some shooting lessons, with Richard hitting 17 out of 25 clays in his first attempt. His father built him a range on the family farm, but just before finishing third in his first world junior championship, his PE teacher said that his hand–eye co-ordination was very poor. It was discovered that Faulds suffered from a weak left eye, which was corrected by special dot-to-dot exercises with such good effect that he now shoots left-handed.

Faulds competed internationally for Britain at the age of 13, and was a world junior champion when he was 16. Three years later, Faulds competed in the 1996 Atlanta Olympics finishing fifth, and became the 1997 European champion. After working at the West London Gun Club for three years as an instructor, Faulds became a full-time shooter, and qualified for the 2000 Sydney games after shooting a then double trap world record score at a World Cup meeting held again in Atlanta, Georgia. Faulds shot a then Olympic record total of 143 in the preliminary round, and won his Olympic gold medal after a shoot-off at the Sydney International Shooting Centre, to become Britain's first shooting gold medal-winner since Malcolm Cooper in 1988.

At the 2004 Athens Olympics, Faulds came 13th in the double trap event, losing his title to Ahmed Al Maktoum from the United Arab Emirates.

Apart from his Olympic career he has also won numerous titles in the sport of English Sporting Clays and FITASC, both of which closely replicate the flight characteristics of live quarry species. His first World title came as a Junior in the FITASC discipline in 1993, a feat he repeated in 1994, 95 and 96 while also collecting Junior World Sporting titles in 1994 and 1995. Since joining the ranks of the Senior Class he has won the World Sporting Championships four times, (2000, 2002, 2006, 2008) the World FITASC Championship four times (2002, 2005, 2007, 2008) and the Beretta World Sporting Championship five times (1998, 2002, 2006, 2008 and 2010).

He has also taken numerous domestic titles including the English Open Sporting (1993, 2003, 2004, 2006, 2008) and the British Open Sporting (1998, 2005).

Richard and Tanya, also a successful shooter in her own right live near Newbury in Berkshire along with their young son Charlie and daughter Lauren.

In 2010 Richard and Tanya opened Owls Lodge Shooting School near Barton Stacey. The ground contains Sporting, Olympic trap, Double trap, Olympic skeet, Universal trench and Down-The-Line layouts.

In 2011, Faulds won individual silver and team gold in the double trap at the European Shooting Championships in Serbia.

On 16 December 2014, Faulds announced his retirement from competitive shooting, ending his career with five Olympic appearances, two bronze medals from the World Championships, a tally of five European medals (one gold, three silver, and one bronze) from the European Championships, an Olympic gold medal from 2000, and a world record in double trap, set in 1998.

Olympic results

References

External links

Richard Faulds profile at BBC Hampshire

1977 births
Living people
Sportspeople from Guildford
People from Longparish
British male sport shooters
Trap and double trap shooters
Olympic shooters for Great Britain
Shooters at the 1996 Summer Olympics
Shooters at the 2000 Summer Olympics
Shooters at the 2004 Summer Olympics
Shooters at the 2008 Summer Olympics
Shooters at the 2012 Summer Olympics
English Olympic medallists
Olympic gold medallists for Great Britain
World record holders in shooting
Members of the Order of the British Empire
Olympic medalists in shooting
Medalists at the 2000 Summer Olympics
Commonwealth Games medallists in shooting
Commonwealth Games bronze medallists for England
Shooters at the 2002 Commonwealth Games
Shooters at the 2006 Commonwealth Games
Medallists at the 2002 Commonwealth Games
Medallists at the 2006 Commonwealth Games


Transaction data or transaction information is a category of data describing transactions. Transaction data/information gather variables generally referring to reference data or master data – e.g. dates, times, time zones, currencies.

Typical transactions are:
 Financial transactions about orders, invoices, payments;
 Work transactions about plans, activity records;
 Logistic transactions about deliveries, storage records, travel records, etc..

Management

Recording and storing transactions is called records management. The record of the transaction is stored in a place where the retention can be guaranteed and where data is archived or removed following a retention period. Formats of recorded transactions can be digital data in databases and spreadsheets, or handwritten texts in physical documents like former bankbooks.

Transaction processing systems are application software that generate transactions and manage transaction data/information, e.g. SAP and Oracle Financials.

Data warehousing
Transaction data can be summarised in a data warehouse, which helps accessibility and analysis of the data.

See also
 Data modeling
 Data architecture
 Information lifecycle management, process of administering digital data storage and applying policies for effective information management

Data management
Transaction processing

References


Protein Wnt-16 is a protein that in humans is encoded by the WNT16 gene. It has been proposed that stimulation of WNT16 expression in nearby normal cells is responsible for the development of chemotherapy-resistance in cancer cells.

Function

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.

WNT16B expression is regulated by nuclear factor of κ light polypeptide gene enhancer in B cells 1 (NF-κB) after DNA damage, as can occur to normal cells during radiation or chemotherapy. Subsequently WNT16B signals in a paracrine manner to activate the Wnt expression program in tumor cells. The expression of WNT16B in the tumor microenvironment attenuates the effects of cytotoxic chemotherapy in vivo, promoting tumor cell survival and disease progression. This implies a mechanism by which cycles of genotoxic therapy might enhance subsequent treatment resistance in the tumor microenvironment.

Model organisms
Model organisms have been used in the study of WNT16 function. A conditional knockout mouse line called Wnt16tm2b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed:  - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping

References

Further reading


Alain (Alanus) (died 1185) was a Cistercian abbot of La Rivour, and bishop of Auxerre from 1152 to 1167. He was a close associate of Bernard of Clairvaux, who was instrumental in getting him appointed bishop, under commission from Pope Eugene III, after a dispute in the diocese. Alain was one of Bernard's biographers.

He was born in Flanders, near Lille, and has often been confused with the later Alain of Lille. The book Doctrinale altum seu liber parabolarum, published c. 1485 is by the latter Alain, who died in 1203.

References
Francis Oakley (1979), The Western Church in the Later Middle Ages, pp. 389–390
The Biographical Dictionary of the Society for the Diffusion of Useful Knowledge (1842), article p. 605.

References

External links
 Biography

1185 deaths
Bishops of Auxerre
12th-century French Roman Catholic bishops
French Cistercians
Year of birth unknown


Angiomotin-like protein 2 is a protein that in humans is encoded by the AMOTL2 gene.

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.

References

External links

Further reading


Clockwork Storybook (CWSB) was a writer's collective and independent book publisher based in Austin, Texas.  It specialized in the fantasy, horror and adventure genres.

History
Clockwork Storybook was formed in the late 1990s by fellow Austin-based writers Mark Finn, Chris Roberson, Lilah Sturges, and Bill Willingham, beginning as a writing group which met weekly to critique its members' short stories and novels. Soon thereafter, the four began producing monthly content for an online shared world anthology of urban fantasy, revolving around the fictitious city of San Cibola, California, where magical inhabitants co-existed with normal citizens, at www.ClockworkStorybook.com. The website is no longer there, and is only partially accessible through the Internet Archive Project, although content from it surfaces occasionally on the respective authors' websites.

Each issue featured a short story by each of the four founders, plus "an occasional story by guest authors invited to play in our fabricated realm", an editorial and intermittent reviews of various notable books, etc. (The second issue, for example, included contributions from artists Brian Hagen and Jeff Dee) In 1999, they were joined by their first 'Associate Member' - Harold Covey, described as an "artist/designer/renaissance man extraordinaire", who designed the ClockworkStorybook logo. (Above, left)

After a couple of years, the development and increasing popularity of print on demand technologies suggested to them that they could create their own imprint (also called Clockwork Storybook) through which they would publish their own novels and short story collections. They launched with four print titles in spring 2001.

Ultimately, after continuing with the online anthology for a couple of years, and publishing a handful of books, the Clockwork Storybook collective fell apart, and the individual authors went their separate ways.

Publications

Several books/anthologies were printed by Clockwork Storybook, and mostly available through the website. Some reprinted online content, many featured new stories. A partial bibliography includes:

 Clockwork Storybook Offline, Volume I: Mythology by Finn, Roberson, Sturges & Willingham
 Clockwork Storybook Offline, Volume II: The Goblin Market by Finn, Roberson, Sturges & Willingham
 Voices of Thunder by Chris Roberson (February 2001)
 Beneath the Skin & Other Stories by Matthew Sturges (March 2001)
 Gods New & Used by Mark Finn (March 2001)
 Down the Mysterly River by Bill Willingham (April 2001)
 Road Trip by Mark Finn
 The Clockwork Reader Volume 1 (Nov 2001) by Clockwork Storybook
 Set the Seas on Fire by Chris Roberson (December 2001) (reprinted by Solaris, 2007)
 Cybermancy Incorporated by Chris Roberson (December 2001) (cover by Michael Lark)
 Year of the Hare by Mark Finn (December 2001)
 Midwinter by Matthew Sturges (February 2002)
 Hyde and Seek by Bill Willingham (May 2002)
 The Monster Maker by Bill Willingham (May 2002)
 Any Time at All: The Lives and Time of Roxanne Bonaventure by Chris Roberson (September 2002) (cover by John Picacio)

After Clockwork Storybook

Bill Willingham is known for his Vertigo Comics series Fables. Matthew Sturges is probably best known as the co-writer (with Willingham) of Fables spin-off Jack of Fables. Mark Finn is a noted Robert E. Howard scholar and playwright. Chris Roberson is author of several books, and publisher of MonkeyBrain Books.

References

External links
Clockwork Storybook content, partially accessible through the Internet Archive
Chris Roberson's homepage
Matthew Sturges' homepage
A partial bibliography of Bill Willingham
Infinity Plus Chris Roberson Timeline
Clockwork Storybook at everything2.com
RevolutionSF article on CWSB's Clockwork Novel Weekend, 2001

Book publishing companies based in Texas
Publishing companies established in the 1990s
Companies based in Austin, Texas


Paris Mountain is a peak of Blue Ridge Mountain on the border of Loudoun County and Clarke County in Virginia. The  peak, which is located just north of Ashby's Gap and the town of Paris, for which it is named, represents the highest elevation in both counties. The peak is accessible by Blue Ridge Mountain Road from the gap. The Appalachian Trail crosses the western slope of the peak.

References

Mountains of Virginia
Mountains of Loudoun County, Virginia
Mountains of Clarke County, Virginia
Blue Ridge Mountains


Replication termination factor 2 is a protein that in humans is encoded by the RTF2 gene.

References

External links

Further reading


NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. SIRT7 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.

Function
SIRT7 facilitates the transcription of DNA by DNA polymerase I, DNA polymerase II, and DNA polymerase III.

In humans cells, SIRT7 has only been shown to interact with two other molecules: RNA polymerase I (RNA Pol I) and upstream binding factor (UBF). SIRT7 is localized to the nucleolus and interacts with RNA Pol I. Chromatin immunoprecipitation studies demonstrate that SIRT7 localizes to rDNA, and coimmunoprecipitation shows that SIRT7 binds RNA Pol I. In addition SIRT7 interacts with UBF, a major component of the RNA Pol I initiation complex. It is not known whether or not SIRT7 is modifying RNA Pol I and/or UBF, and if so, what those modifications are.

SIRT7 is expressed more in metabolically active tissues, such as liver and spleen, and less in non-proliferating tissues, such as heart and brain. Furthermore, it has been shown that SIRT7 is necessary for rDNA transcription. Knock down of SIRT7 in HEK293 cells resulted in decreased rRNA levels. This same study found that this SIRT3 knockdown decreased the amount of RNA Pol I associated with rDNA, suggesting that SIRT7 may be required for rDNA transcription. Knock down SIRT7 led to reduced RNA Pol I levels, but RNA Pol I mRNA levels did not change. This suggests that SIRT7 plays a crucial role in connecting the function of chromatin remodeling complexes to RNA Pol I machinery during transcription.

SIRT7 may help attenuate DNA damage and thereby promoting cellular survival under conditions of genomic stress. Ribosomal DNA (rDNA) is more vulnerable to DNA damage than DNA elsewhere in the genome such than rDNA instability can lead to cellular senescence, and thus to senescence-associated secretory phenotype. SIRT7 localizes to rDNA thereby protecting against rDNA instability and cellular senescence.

DNA repair

Depletion of SIRT7 results in impaired repair of DNA double-strand breaks (DSBs) by the process of non-homologous end joining (NHEJ).  DSBs are one of the most significant types of DNA damage leading to genome instability.  SIRT7 is recruited to DSBs where it specifically deacylates histone H3 at lysine 18.  This affects the focal accumulation of the DNA damage response factor 53BP1, a protein that promotes NHEJ by protecting DNA from end resection.

SIRT7 overexpression has been shown to improve efficiency of NHEJ by 1.5-fold, and of homologous recombination by 2.8-fold.

Accelerated aging

Sirt7 mutant mice show phenotypic and molecular features of accelerated aging.  These features include premature curvature of the spine, reduced weight and fat content, compromised hematopoietic stem cell function and leukopenia, and multiple organ dysfunction.

Clinical relevance

This gene has been found to be involved in maintenance of oncogenic transformation.

References

Further reading


St. John's Parish Church in Barbados is the first church of St. John that is presumed to have been a simple wooden building, but its date is unknown.  The parish along with St. George, was carved out of St. Michael in 1640–1641.  But successive churches were badly damaged by the hurricane of 1675, the Great Hurricane of 1780, and finally destroyed by the 1831 Barbados–Louisiana hurricane. The present church building (the fifth) was built is 1836, and the chancel added in 1876.  It is the prototype of the restrained Barbadian version of the Gothic parish church, and a beautiful Westmacott sculpture, commemorating Elizabeth Pinder, on the left of the main door.

References

Religious buildings and structures in Barbados
Saint John, Barbados


PPAP may refer to:

 Production part approval process, an automotive supply chain process
 (-)-1-Phenyl-2-propylaminopentane, a stimulant drug
 "PPAP (Pen-Pineapple-Apple-Pen)", a 2016 single and viral video by Japanese singer and comedian Pikotaro

See also
 PEPAP (phenethylphenylacetoxypiperidine), an opioid analgesic


Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. SIRT6 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.

Research
Sirt6 is mainly known as a deacetylase of histones H3 and H4, an activity by which it changes chromatin density and regulates gene expression. The enzymatic activity of Sirt6, as well as of the other members of the sirtuins family, is dependent upon the binding of the cofactor nicotinamide adenine dinucleotide (NAD+).

Mice which have been genetically engineered to overexpress Sirt6 protein exhibit an extended maximum lifespan. This lifespan extension, of about 15–16 percent, is observed only in male mice.

DNA repair

SIRT6 is a chromatin-associated protein that is required for normal base excision repair and double-strand break repair of DNA damage in mammalian cells.  Deficiency of SIRT6 in mice leads to abnormalities that overlap with aging-associated degenerative processes.  A study of 18 species of rodents showed that the longevity of the species was correlated with the efficiency of the SIRT6 enzyme.

SIRT6 promotes the repair of DNA double-strand breaks by the process of non-homologous end joining and homologous recombination.  SIRT6 stabilizes the repair protein DNA-PKcs (DNA-dependent protein kinase catalytic subunit) at chromatin sites of damage.

As normal human fibroblasts replicate and progress towards replicative senescence the capability to undergo homologous recombinational repair (HRR) declines.  However, over-expression of SIRT6 in “middle-aged” and pre-senescent cells strongly stimulates HRR.  This effect depends on the mono-ADP ribosylation activity of poly(ADP-ribose) polymerase (PARP1).  SIRT6 also rescues the decline in base excision repair of aged human fibroblasts in a PARP1 dependent manner.

Activators

Sirt6 deacetylation activity can be stimulated by high concentrations (several hundred micromolar) of fatty acids, and more potently by a first series of synthetic activators based on a pyrrolo[1,2-a]quinoxaline scaffold. Crystal structures of Sirt6/activator complexes show that the compounds exploit a SIRT6 specific pocket in the enzyme's substrate acyl binding channel. Among many anthocyanidins studied, cyanidin most potently stimulated activity of the SIRT6.

References

External links

Aging-related proteins


Mogapi is a village in Central District of Botswana. The village is located 47 km south of Selebi-Phikwe and is less than 100 km from the border with South Africa. The population was 1,814 in 2001 census.

References

Populated places in Central District (Botswana)
Villages in Botswana


The St. Joseph Civic Arena is a 3,800-seat multi-purpose arena built in 1980 in St. Joseph, Missouri USA.  It is used mainly to host indoor sporting events, such as basketball, arena football and National Bull Riding Finals.  It has hosted two American Professional Football League franchises, the St. Joseph Explorers in 2003 and the St. Joseph Storm in 2005.  It hosted the NCAA Women's Division II Basketball Championship in 2003, 2004, 2010 and 2011. It has and continues to host the National Federation of Professional Bullriders' National Finals, 2012 will mark their 14th year at the Civic Arena. The arena is also home to the Blacksnake Rollergirls MADE roller derby league.

The Arena immediately adjacent to the I-229 downtown St. Joseph exit was designed by Patty Berkebile Nelson and opened in 1980 and was part of a downtown St. Joseph urban renewal project.  Other work in the same issue included purchase and extensive renovation of the Missouri Theater and Missouri Theater Building.

External links
Arena homepage

Sports venues in Missouri
Indoor arenas in Missouri
Buildings and structures in St. Joseph, Missouri
Tourist attractions in Buchanan County, Missouri
Basketball venues in Missouri
1980 establishments in Missouri
Sports venues completed in 1980


VOY or Voy may refer to:

 Star Trek: Voyager, a science fiction television series in the Star Trek franchise
 Voices of Youth, an organization set up by UNICEF to help children from across the world exchange knowledge and ideas
 Voy, a settlement in the Orkney Islands of the north of Scotland
 Voy's Beach, a settlement located northwest of Corner Brook
 Voy (study abroad), a study abroad organization in the United States
 Wikivoyage, with interwiki code "voy"

See also
 Mazet-Saint-Voy, Haute-Loire, France; a commune which contains the parish of Saint-Voy de Bonas (Saint-Voy)

fr:VOY


The Danube Legion (; or the Rhine Legion - ) was a unit of Poles in the service of Napoleonic France. It was also known as the 3rd Polish Legion.

Origin
It was formed on 8 September 1799 in the Batavian Republic from Polish volunteers, mostly French prisoners of war from the Austrian Army. Numbering about 6,000 the legion was commanded by general Karol Kniaziewicz.

The legion fought at the Battle of Marengo and Battle of Hohenlinden. However during treaty negotiations between the French and the Austrians, the French were finding the Polish issue to be a problem; the Poles wanted the French to continue fighting against the partitioners of Poland; the future Polish national anthem, Mazurek Dąbrowskiego, created by Józef Wybicki, promised 'the return of the Polish army from Italy to Poland'. Instead, the French used Polish troops to quell down uprisings in conquered territories, which led to much unrest amongst the Polish troops. The prospect of being assigned to Louis I of Etruria, Napoleons appointee as the King of Etruria did not sit well with their republican sympathies. As the King also felt reluctant to take financial responsibility for them, Napoleon reassigned them to quell the Haitian Revolution which was currently giving him problems. General Jan Henryk Dąbrowski initially complained from his headquarters in Milan, but subsequently acquiesced. After Stanisław Fiszer had turned down the command in favour of returning to Poland, Fortunat Bernard, a Frenchman, was appointed. After a storm had thwarted an initial attempt to depart, the 3rd Polish Demi-brigade left Livorno on May 17, 1802, reaching Cadiz by July 11. It was here that Bernard applied to the French government that the demi-brigade be reassigned as a French line infantry demi-brigade. The fleet set sail again on July 24, and it was only at this stage that many of the Poles were informed that they were bound for Haiti.

113th Line Infantry Demi-brigade
On 4 September 1802, two days after arriving in Cap Francais, Haiti, Louis-Alexandre Berthier, the French War Minister redesignated the 3rd Polish Demi-brigade as the 113th Demi-brigade. However news of this change of name did not reach Haiti until November, by which time the demi-brigade had suffered major casualties. Eventually combat casualties and tropical diseases (like the yellow fever) reduced the 5,280 strong Legion to a few hundred survivors in the space of less than two years. By the time French forces retreated from the island in 1803 about 4,000 Poles were dead (either from disease or combat), a few hundred chose to switch sides and remain on the island.

1st Battalion
The 1st Battalion was commanded by Wodzinski and joined the French Northern Division led by General Jean Boudet, but soon to be replaced by General Bertrand Clausel. Upon arrival on September 2, Charles Leclerc reckoned their strength as 984. By the end of November they were estimated to be 80 men who were then attached to the French 74th Line Infantry Demi-brigade. By September 23, 1803, French military records state that only 6 officers and 14 men were still alive.

2nd Battalion
The 2nd Battalion was commanded by Wojciech Bolesta and was assigned to Jean-Jacques Dessalines mixed division. It comprised eight regular companies plus accompany of grenadiers consisting of 775 men in all.

3rd Battalion
The 3rd Battalion were commanded by Franciszek Grabski. They were assigned to the Right Northern Division commanded by General Jean Baptiste Brunet. Of the original 21 officers and 768 soldiers only 634 men joined Brunet's division, the remainder being in hospital. The 3rd Company was under the command of Captain Sangowski, who understood little French. He unwisely led them into an exposed position at Dubrail, an unfortified plantation where they were attacked by rebels. After running out of ammunition they surrendered, only to find that the rebels started massacring them. However, Navarrez led some troops of the 86th Line Infantry Demi-brigade to their rescue, by which time only four were still alive, a total of thirty five having been killed. Sangowski, who had escaped by hiding in a swamp later died of pneumonia, thus avoiding court-martial.

References

Bibliography

Polish Legions (Napoleonic period)
Military units and formations established in 1799
Military units and formations disestablished in 1803
French military units and formations of the Napoleonic Wars
Military history of Poland
Regiments of the French First Republic


"With Me" is the third single from Sum 41's 2007 studio album Underclass Hero. A ballad, the first live performance of "With Me" was on January 26, 2008 at the Daytona International Speedway in Daytona Beach, Florida. On February 4, Sum 41 announced that they had filmed the video for "With Me", and the song was later featured on Season 1, Episode 7 of Gossip Girl. The song was featured on the commercial for the 2009 Fox series More to Love. The song charted at 37 in the Canadian Singles Chart. With a running time of 4 minutes and 51 seconds, "With Me" was the band's longest song for nine years until it was surpassed by the 5-minute "Twisted By Design" from 2016's 13 Voices.

Music video
The music video was released on the band's MySpace page on February 28.  The band announced that the video was shot near Toronto, Ontario. It starts off with Deryck Whibley playing an acoustic guitar as shots show around the house he is playing in. There are many shots of pictures and people (including one of the Shriners). Each of these people has different uses for pictures and photos (e.g. the old man uses his pictures to remember his old days in the army and the young couple use them to take photos of themselves together). There is then shots of Whibley, Jason McCaslin, and Steve Jocz playing in a room where they play the chorus of the song; they then use this room to play the rest of the song in. We then learn more about the people and why their pictures are so important to them. More is revealed about them as the second verse goes on. Then, just before the second chorus, a framed picture with a moving image of Whibley walking  is shown. As Whibley walks, the environment behind him changes rapidly showing many different places. After this, the song goes back to being acoustic for 8 bars. During this, Whibley is shown playing his acoustic guitar again. Also, the people in the house begin to freeze frame and turn into framed pictures of themselves. The song then continues and ends. The video shows the many aspects of the song.

Live performances
The first live performance of "With Me" was on January 26, 2008 at the Daytona International Speedway in Daytona Beach, Florida for Jimmy Kimmel Live!.

Charts

References

External links

2007 singles
Sum 41 songs
2007 songs
Rock ballads
Songs written by Deryck Whibley
Island Records singles


Ras-related protein Rab-6B is a protein that in humans is encoded by the RAB6B gene.

References

Further reading


Sumner–Bonney Lake School District is a school district in Washington, that serves the cities of Bonney Lake, Edgewood, Sumner, and unincorporated areas of east Pierce County, Washington.  The district has 14 schools, a family support center, a district athletic complex, two performing arts centers, public gymnasiums, and a recreation department.

Boundary
The district includes the majority of Sumner and most of Alderton, Bonney Lake and North Puyallup. The district also includes portions of Edgewood, Lake Tapps, McMillin, Pacific (Pierce County portion), Prairie Ridge, and Tehaleh.

Elementary schools
 Bonney Lake Elementary, Bonney Lake, Established 1961 (Renovated 2010)
 Crestwood Elementary, Bonney Lake
 Daffodil Valley Elementary, Sumner
 Donald Eismann Elementary, Tehaleh, Established 2010
 Emerald Hills Elementary, Bonney Lake, Established 1979 (Rebuilt 2019)
 Liberty Ridge Elementary, Bonney Lake Established 1998
 Maple Lawn Elementary, Sumner
 McAlder Elementary, Puyallup, Permanently closed in 2012, and now being used by Cascade Christian Schools
 Tehaleh Heights Elementary, Tehaleh, Established 2018
 Victor Falls Elementary, Bonney Lake

Middle schools
 Lakeridge Middle School, Bonney Lake, EST 1980 as Lakeridge Junior High (Rebuilt in 2010 and as Lakeridge Middle School)
 Mountain View Middle School, Bonney Lake, EST 1998 (Currently in renovation as of Mid 2021)
 Sumner Middle School, Sumner, EST as Sumner Junior High (Changed to Sumner Middle School in 2006 and renovated in 2012)

High schools
 Bonney Lake High School, Bonney Lake EST 2005
 Sumner High School, Sumner EST circa early-1900s in 3-story brick traditional structure; followed by newer 1-story building constructed 1954 (Building expansion completed as of May 2023)

References

https://www.sumnersd.org/site/Default.aspx?PageID=3945#:~:text=1%2F13%2F22-,Sumner%20High%20School's%20Modernization%20and%20Expansion%20Phase%201%20construction%20project,technology%2C%20security%2C%20restrooms).

External links

School districts in Washington (state)
Education in Pierce County, Washington


The International Maritime University of Panama (in Spanish: Universidad Marítima Internacional de Panamá, UMIP) is a maritime college in Panama City, Panama. It trains cadets to become merchant marine ships' officers. It is located in the Albrook area of Panama City, on the site of the former Albrook Air Force Base.

Today, the Maritime university is experiencing one of its best times.  Their cadets are recognized for their leadership, respect, honor, loyalty, discipline, and non-tolerance of dishonest acts.  It belongs to the international association of maritime universities, being the only one in Central and South America to achieve this step.

Its main building (Building 810 in Albrook) was severely damaged by a fire in January 2008, although there were no injuries or fatalities. The fire is believed to have started in a storage area on the building's top floor.

UMIP was established by a law passed in 2005, and it absorbed the former Escuela Náutica de Panamá, which was founded in 1958.

The university's rector (president) is  Víctor Luna Barahona.

Cadets Corp

To create leaders, the UMIP established and executed a discipline system Cadet Corp, proposed and defended by all, which institutes the habits that eventually become culture, as a result of the individual. The UMIP trains cadets by leading them through a continuous and focused process in the enhancement of values and competences that train the individual for life and for work in the sea.

Under command of the merchant marine captain, Eduardo Thompson, UMIP has a strong and stable cadet regiment.  The regiment is divided between platoons: Alpha, Bravo, Charlie, Delta, Echo, Band Company and the outstanding Honor Guard. In addition to the captain, the cadets choose among them their representatives before the school of leadership, who are:
Brigadier higher
Executive Brigadier
Administrative Brigadier
Leadership chief
Chief of student dining room
Chief of Alpha platoon.
Chief of Bravo Platoon
Chief of Charlie Platoon
Chief of Delta Platoon
Chief of Echo platoon
Honor Guard Chief

References

External links

Martín Torrijos, President of Panama - Discurso en Sanción de Ley que crea la Universidad Marítima Internacional de Panamá (Speech on signing the law establishing UMIP), December 1, 2005

Maritime colleges
Universities in Panama
Buildings and structures in Panama City
Education in Panama City


Ubiquitin-fold modifier 1, also known as UFM1, is a protein which in humans is encoded by the UFM1 gene.

UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme  UBA5 and E2-like conjugating enzyme UFC1. This process is often referred to as UFMylation.

Function
UFM1 shares several common properties with ubiquitin (Ub) and the other ubiquitin-like proteins (UBLs). Ufm1 has similar tertiary structure to Ub but lacks any obvious sequence similarity. It is synthesized as an inactive precursor form (pro-Ufm1) which has 2 additional amino acids beyond the conserved glycine. The mechanism of Ufm1 conjugation is similar to that of ubiquitin. Mature Ufm1 has an exposed C-terminal glycine which is essential for subsequent activation by its cognate E1 protein (Uba5). This activation step results in the formation of a high-energy thiolester bond in the presence of ATP. The Ufm1 is subsequently transferred to its cognate E2-like enzyme (Ufc1) via a similar thioester linkage with a cysteine at the E2 active site. Ufm1 is conjugated to a variety of target proteins and forms complexes with as yet unidentified proteins. Thus, presumably there exist E3 ligases (none have been identified to date) to perform the final step in Ufm1 conjugation to relevant targets. The modification of proteins with Ufm1 is also reversible. Two novel cysteine proteases have been identified to date (UFSP1 and UFSP2) which cleave Ufm1-peptide C-terminal fusions and also removes Ufm1 from native intracellular conjugates. These proteases have no obvious homology to ubiquitin deconjugating enzymes. The proteins for Ufm1 conjugation (Uba5, Ufc1 and Ufm1) are all conserved in animals and plants (but not yeast) suggesting important roles in multicellular organisms. The exact role of Ufm1 modification in vivo is not yet known, but the primary target appear to be uL24/RPL26 in human cells.

References

Further reading

External links


The Little Mermaid: Ariel's Beginning (also known by the working title, The Little Mermaid III: Ariel's Beginning or The Little Mermaid 3: Ariel's Beginning) is a 2008 animated direct-to-video fantasy film produced by Disneytoon Studios, with the animation production being done by Toon City and DisneyToon Studios Australia. This film is the prequel to Disney's 1989 animated feature film The Little Mermaid, the third installment in The Little Mermaid trilogy, and the last direct-to-video sequel after John Lasseter took over as chairman for the Disney Animation Division. It is also the first in the chronology of the story running through the series and it is based on the fairy tale The Little Mermaid of the same name by Hans Christian Andersen and Disney's The Little Mermaid by Walt Disney Animation Japan and Walt Disney Television.

Directed by Peggy Holmes, the film's story is set before the events of the original film, when Ariel is still young, and when all music has been banned from the underwater kingdom of Atlantica by King Triton after being heartbroken at his wife's death, and Ariel attempts to challenge this law. Jodi Benson and Samuel E. Wright (in his final film role) reprise their roles as Ariel and Sebastian respectively, while Sally Field voices the film's new villainess, Marina Del Rey. Jim Cummings takes over the role as King Triton, replacing Kenneth Mars, who had been diagnosed with pancreatic cancer.

The film was released by Walt Disney Studios Home Entertainment on August 26, 2008. Though critical reception was improved over its predecessor, the film received mixed reviews that criticized the score, while the animation, screenplay, and voice performances were praised.

Plot

King Triton and his wife, Queen Athena, rule over the underwater kingdom of Atlantica, filled with music and laughter. They have seven young daughters: Attina, Alana, Adella, Aquata, Arista, Andrina, and the youngest of whom is Ariel. One day, while the merpeople relax in a lagoon above the surface, King Triton gifts Queen Athena a music box. However, the merfolk flee at the approach of a pirate ship. Everyone escapes except Queen Athena, who, while trying to recover the music box, is killed when the ship crashes into the lagoon. Devastated by his wife's death, Triton, having become bitter of music, throws the music box away and permanently bans music from Atlantica.

Ten years later, Ariel and her sisters live under a strict routine maintained by their evil governess, Marina Del Rey and her kindly assistant, Benjamin the manatee. Marina hates being the girls' governess and longs to be King Triton's attaché, a job currently filled by Sebastian the crab. Ariel is frustrated by their current lifestyle, which brings her into arguments with her father. One day, Ariel encounters Flounder, a young tropical fish whom she later follows to an underground music club. She is overjoyed by the presence of music and is shocked when she sees Sebastian performing there. When her presence is revealed, the entire band stops playing and hides, believing Ariel will tell her father about them. Ariel sings a song explaining her love of music and the remembrance of her mother and is then accepted as a member of the club after swearing an oath of secrecy.

Ariel returns to the palace and her sisters confront her over her disappearance, she explains where she was and the following night the girls go to the club to have fun. Marina finds them and she later reports their activities to King Triton, who destroys the club with his trident. Sebastian, Flounder, and the band are sent to prison, while Marina is given Sebastian’s position, which means she will change the rules of Atlantica the next morning. The girls are confined to the palace as punishment. Ariel angrily retorts that this is not what her mother would have wanted.

That night, Ariel frees her friends and leaves Atlantica. Sebastian leads them to a deserted place far away from the palace where Ariel finds Queen Athena's music box, as Sebastian hoped. Ariel, Flounder, and Sebastian decide to return to Atlantica, stop Marina and Benjamin from changing the laws, and bring the music box to King Triton, hoping that it will change his mind, as he has not remembered how to be happy after Queen Athena's death. Meanwhile, King Triton is informed that Ariel is missing and he orders his guards to find her. Marina, wanting to retain her position, releases her electric eels to hunt down and eliminate Ariel and Sebastian.

Ariel and her friends are confronted by Marina on their way back and a struggle ensues. Ariel’s friends defeat Marina’s eels, just as King Triton arrives. Marina barrels toward Sebastian and tries to kill him, but Ariel blocks her way, getting hit in the process, and falls, apparently dead.  King Triton witnesses this and blames himself. He, having a change of heart and making his bitterness of music go away, sings to Ariel and she revives; the two of them reconcile. After that, music is soon restored to Atlantica after ten years, Marina and Benjamin are imprisoned in the dungeon by King Triton as punishment for their crimes, Sebastian is appointed Atlantica's first official court composer, and everyone celebrates.

Voice cast

 Jodi Benson as Ariel, the 15-year-old adventurous and headstrong mermaid princess of Atlantica.
 Samuel E. Wright as Sebastian, a red Caribbean crab with a Jamaican accent who serves as King Triton's advisor and court composer. This was Wright's final film role before his death in 2021.
 Jim Cummings as King Triton, Ariel's strict and overprotective father and the ruler of Atlantica who is prejudiced towards humans. Cummings replaces Kenneth Mars, who was battling cancer.
 Cummings also voices Shelbow, a member of the Catfish Club Band.
 Sally Field as Marina Del Rey.
 Parker Goris as Flounder, a yellow tropical fish who is Ariel's best friend.
 Kari Wahlgren as Attina, the eldest sister who keeps the others in order and is always following her father's words.
 Tara Strong (previously the voice of Melody, the daughter of Ariel, in Return to the Sea) as:
 Adella, the third eldest sister who dreams of falling in love with a boy.
 Andrina, the second youngest sister who is sarcastic and likes to joke around.
 Jennifer Hale as Alana, the second eldest sister who is interested in beauty, fashion and is very cautious with her appearance.
 Grey DeLisle as:
 Aquata, the middle sister who is tough, but shy and can't dance.
 Arista, the third youngest sister who is very quirky and often "borrows" other people's things. She joins the band at the end of the movie.
 Jeff Bennett as Benjamin, Marina's mild-mannered manatee sidekick.
 Bennett also voices the Swordfish Guards who patrol the palace.
 Lorelei Hill Butters as Queen Athena
 Andrea Robinson as Queen Athena's singing voice
 Rob Paulsen (previously the voice of Prince Eric in Return to the Sea) as Ink Spot and Swifty, members of the Catfish Club Band.
 Kevin Michael Richardson as Cheeks and Ray-Ray, members of the Catfish Club Band.

Production
The film's working title was The Little Mermaid III, and it was originally scheduled for a mid-2007 release. When John Lasseter took over Disney Animation, more resources were spent on completing Cinderella III: A Twist in Time, and attention only returned to this film in July 2006 after the wrap-up of Cinderella III.

A teaser trailer and musical preview of the film (an alternate version of "Jump in the Line") were attached to the Platinum Edition DVD of The Little Mermaid, which was released in October 2006. At the time, the working title The Little Mermaid III was still being used.

Like The Little Mermaid II: Return to the Sea, this film uses digital ink and paint with the use of the Toon Boom Harmony software.

Soundtrack
The score to the film was composed by James Dooley, who recorded the score with a 72-piece ensemble of the Hollywood Studio Symphony, as well as a big band, at the Sony Scoring Stage. The film features new songs written by Jeanine Tesori, along with covers of previously recorded calypso songs that were arranged by Dooley. No soundtrack has been released yet for the film.

Release
The film was released on Region 1 DVD in the United States on August 26, 2008, and on Region 2 DVD in the United Kingdom and Europe on September 22, 2008. The DVD contains special features including deleted scenes, a production featurette hosted by the director, games and activities, and a featurette hosted by Sierra Boggess (who played Ariel on Broadway) about the Broadway musical.

On December 16, 2008, the film was released in a "The Little Mermaid Trilogy" boxed set that includes The Little Mermaid (Platinum Edition) and The Little Mermaid II: Return to the Sea. On November 19, 2013, it was released on Blu-ray as a 2-movie collection alongside the sequel.

In 2019, the film was released on Disney+.

Censorship in the United Kingdom
In the United Kingdom, the word "spastic" was cut from an interactive game in the extra features of the DVD and Blu-Ray releases by the BBFC to achieve a "U" rating. An uncut version was available rated "12".

The word appears uncensored in all versions of the full-length feature.

Reception
The DVD became the top-selling DVD for the week ending August 31, selling 980,237 copies.

 On the review aggregate website Rotten Tomatoes, 33% of 6 critic reviews are positive. The new villain, Marina Del Rey, was criticized as a poor follow-up to Ursula. The animation quality of the film has been praised as being "impressive" for a direct-to-video and comparable to that of the original film. A mildly negative review has described that in the film "goofiness often gets buried too often underneath a blah story that's much too run-of-the-mill to allow the emotional oomph of the characters' plights to truly impact". The music has also been criticized as being unmemorable, with one review stating that "to label this a musical would be false advertising".

References

External links

2008 films
2000s American animated films
2008 direct-to-video films
2000s musical fantasy films
American musical fantasy films
American children's animated fantasy films
American children's animated musical films
Direct-to-video prequel films
Disney direct-to-video animated films
DisneyToon Studios animated films
Little Mermaid Ariel's Beginning
Films directed by Peggy Holmes
Films scored by James Dooley
Animated films set in a fictional country
Films about dysfunctional families
Buddhist media
Films with screenplays by Evan Spiliotopoulos
2008 directorial debut films
Animated films based on The Little Mermaid
Animated films about father–daughter relationships
2000s English-language films
American prequel films


Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.

References

External links

Further reading