Protein FAM40A is a protein that is located on chromosome 1 in humans and is encoded by the FAM40A gene.

Characteristics and secondary structure
FAM40A has an isoelectric point of 5.92 and a molecular weight of 95,575 daltons.  It is predicted to have three transmembrane domains, making it a transmembrane protein. FAM40A does not contain a signal peptide and is also predicted to bind to DNA, possibly making it a membrane protein in the nuclear membrane.

The secondary structure of FAM40A is predicted to contain twenty-six alpha helices and two beta sheets. The 5' untranslated region of FAM40A is predicted to contain one stem-loop and the 3' untranslated region is predicted to contain eight stem-loop structures. Two miRNAs are predicted to bind to two of the stem-loop structures present in the 3' UTR region.

Homology
FAM40A has no paralogs. However, it does have orthologs stretching all the way back to yeast. It has been suggested that FAM40A is a homolog to the yeast gene FAR11, which is involved in the recovery from cell cycle arrest.

The following table represents a small selection of orthologs found using searches in BLAST and BLAT.  This is by no means a comprehensive list, however it does show the vast diversity of species where FAM40A orthologs are found.

Expression
FAM40A is expressed in high levels during the blastocyst, eight-cell stage, and fetal stages of development. FAM40A has also been shown to be expressed in high levels in the mammary glands, brain, thymus, mouth and the testes. It has also been shown to be expressed in high levels in mammary gland tumors, leukemia cells, and germ cell tumors.

Transcription Regulation
FAM40A is predicted to have a promoter region 789 base pairs upstream of the start of transcription. The SOX transcription factors are predicted to bind to the promoter region of the FAM40A gene, possibly indicating a role in sex determination.

Interactions
FAM40A has been shown to interact with RP6-213H19.1, STRN, PDCD10, TRAF3IP3, STRN3, PPP2R1A, MOBKL3, CTTNBP2NL, STK24 and PPP2CA.

References

Further reading


ELL-associated factor 1 is a protein that, in humans, is encoded by the EAF1 gene. It is part of the EAF family of proteins.

References

Further reading


DnaJ homolog subfamily C member 14 is a protein that in humans is encoded by the DNAJC14 gene.

Interactions
DNAJC14 has been shown to interact with Dopamine receptor D1.

References

Further reading

Heat shock proteins


Le Vernet (; ) is a commune in the Alpes-de-Haute-Provence department, and in the region of Provence-Alpes-Côte d'Azur, in southeastern France.

The name of its inhabitants is Vernetois or Vernetiers.

Geography

The village of Le Vernet is located in the  Valley at  altitude. Its population does not exceed 100 permanent residents, but it is often more than doubled each summer and winter, when the municipality becomes the place of departure for sightseeing excursions, particularly in the  Valley, and a place of departure for the nearby ski stations (Grand-Puy,  and Chabanon).

The municipality has two main villages, Haut-Vernet, perched high and Bas-Vernet below.

Geology
During the two last major glaciations, the Riss glaciation and the Würm glaciation, a glacier was present in the upper part of the Riou de la Montagne Valley. During the Riss glaciation, a  of the Blanche glacier crossed the Col de Maure and reached approximately to the location of the village of the current Bas-Vernet. The diffluence was reproduced during the Würm period, but did not reach the territory of Vernet.

Relief
The Pic des Têtes, at , is located within the territory of the commune, as well as the , in the Massif des Trois-Évêchés.

Environment
The commune comprises  of woods and forests.

Transport

Natural and technological hazards

None of the 200 communes of the Department is in the zero seismic risk zone. The Canton of Seyne, to which Le Vernet belongs, is in zone 1b (low seismicity) determined by the 1991 classification, based on the historical earthquakes, and in zone 4 (medium risk) according to the probabilistic classification EC8 of 2011. The municipality of Le Vernet is also exposed to four other natural hazards:

Avalanche
Forest fire
Flooding
Ground movement

The commune of Le Vernet is more exposed to a risk of technological origin, that of transport of dangerous goods by road. The  RD 900 (the former ) can be used for the road transport of dangerous goods.

A predictable natural  (PPR) doesn't exist for the commune and  does not exist either.

History remembers two earthquakes to have been strongly felt in the town. They exceeded a macro-seismic intensity level V on the MSK scale (sleepers awake, falling objects). The specified intensities are those felt in the town, the intensity can be stronger at the epicentre:

The earthquake of 22 March 1949 had an intensity level V, and with Le Lauzet at the epicentre
The earthquake of 31 October 1997 had an intensity level V, and with Prads-Haute-Bléone at the epicentre

Toponymy
According to the Fénie couple, the name of Le Vernet refers to alder.

History
During antiquity, the Bodiontiques (Bodiontici) lived in the Bléone Valley, and were therefore the Gallic people who lived in the current municipality of Vernet. The Bodiontiques, who were defeated by Augustus at the same time as other peoples present on the Tropaeum Alpium (before 14 BC), are attached to the province of Alpes Maritimae at its inception.

The town appears for the first time in charters in the 11th century. The Priory of Saint-Clément was under the Abbey of Saint-Victor in Marseille, via the Priory of Chaudol (now in La Javie). The priory decided the questes and the taille, the lord decided the cavalcade and the albergue. The Comte of Provence Ramon Berenguer IV granted to the community, who reported to the Bailli of Seyne, a  in the 13th century.

In the Middle Ages, the great road of Digne to Seyne passed, descending from the Col du Labouret, by Haut-Vernet, without following the Bès Valley.

In 1602, the trial exploitation of a vein of copper was cut short, the deposit actually being very poor. As early as 1604, the owners couldn't pay the workers, some were sent to Villevieille and Verdaches. These mines were given a new concession in 1614, without which their operation would never have restarted.

During the French Revolution, the town had a , created after the end of 1792.

As with many communes of the Department, Le Vernet acquired schools well before the Jules Ferry laws: In 1863, it had one each at Haut-Vernet and Bas-Vernet, which provide a primary education for boys. While the Falloux Laws of 1851 required the opening of a girls school for communes with more than 800 inhabitants, and the first  of 1867 lowered the threshold to 500 inhabitants, Le Vernet nevertheless opened a school for girls, ahead of the laws. The commune took advantage of subsidies from the second Duruy Law in 1877 to build a new school at Haut-Vernet.

On 24 March 2015, Germanwings Flight 9525, an Airbus A320 flying from Barcelona to Düsseldorf, crashed in the mountains of the neighboring commune of Prads-Haute-Bléone, near to the border with Le Vernet.

Politics and administration

Population and society

Demography

In 2017, Le Vernet had 123 inhabitants. From the 21st century, communes with less than 10,000 inhabitants have a census held every five years (2004, 2009 and 2014, etc. for the Vernet). Since 2004, the other figures are estimates.

The demographic history of Le Vernet, after the depopulation of the 14th and 15th centuries and long movement of growth until the beginning of the 19th century, is marked by a period of 'spread' where the population remains stable at a high level. This period lasts from 1806 to 1846. The  then caused a rapid decline in population, most importantly a long-term movement. Between 1911 and 1921, the municipality records the loss of more than half of its population (relative to the historic maximum). The downward movement is interrupted only in the 1980s. Since then, the population has doubled.

Education

The town depends on the . It has a primary school, consisting of 9 students.

Religion
The Catholic parish of Le Vernet depends on the Diocese of Digne, Riez and Sisteron.

Local culture and heritage

Sites and monuments
In Bas-Vernet, the parish church of Sainte-Marthe dates from the 19th century.

At Haut-Vernet, the Saint-Martin Church is also from the 19th century.

The chapel of Saint-Pancrace, isolated above Haut-Vernet, is the old parish church. Ruined by the European wars of religion, it was rebuilt, and its roof was repaired again in the 20th century.

The Oratory of Saint-Roch

Notable people
Gaspard Laurent Bayle, physician to Napoleon
 has a monument at the

Heraldry

See also
Communes of the Alpes-de-Haute-Provence department

Bibliography

 (BnF no. FRBNF35450017h)

References

External links

Le Vernet on the website of the French National Geographic Institute (Archived)

Communes of Alpes-de-Haute-Provence


The 2008 Mississippi State Bulldogs football team represented Mississippi State University during the 2008 NCAA Division I FBS football season. The team's head coach was Sylvester Croom. The Bulldogs played their six home games in 2008 at Davis Wade Stadium at Scott Field in Starkville, Mississippi and finished with a 4–8 overall record.

Croom resigned at the end of the season and on December 10, Mississippi State hired Florida offensive coordinator Dan Mullen.

Schedule

Rankings indicate opponent's position in AP Poll as released week prior to game. Schedule Source:

Game summaries

Louisiana Tech

Last Meeting: September 21, 1996, L 23–38Series Record: MSU leads 7–2

Southeastern Louisiana

Last Meeting: Never MetSeries Record: Never Met

Auburn

Last Meeting: September 15, 2007, W 19–14Series Record: MSU trails 23–56–2

Georgia Tech

Last Meeting: October 5, 1929, L 13–27Series Record: MSU trails 0–2

LSU

Last Meeting: August 30, 2007, L 0–45Series Record: MSU trails 33–65–3

Vanderbilt

Last Meeting: October 2, 2004, L 13–31Series Record: MSU leads 10–7–2

Tennessee

Last Meeting: October 13, 2007, L 21–33Series Record: MSU trails 15–27–1

Middle Tennessee

Last Meeting:October 28, 2000,W 61–35Series Record: MSU leads 2–0

Kentucky

Last Meeting: October 27, 2007, W 31–14Series Record: MSU trails 15–20

Alabama

Last Meeting: November 10, 2007, W 17–12Series Record: MSU trails 18–71–3

Arkansas

Last Meeting: November 17, 2007, L 31–45Series Record: MSU trails 5–12–1

Ole Miss

Last Meeting: November 23, 2007, W 17–14Series Record: MSU trails 39–59–6

Statistics
Mississippi State Overall Team Statistics (as of Oct 11, 2008)

Team

Scores by quarter

Offense

Rushing

Passing

Receiving

Defense

Special teams

Coaching staff

References

Mississippi State
Mississippi State Bulldogs football seasons
Mississippi State Bulldogs football


Peroxisomal proliferator-activated receptor A interacting complex 285, also known as PRIC285, is a human gene.

The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

References

Further reading


Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.  Siglec-G is often referred to as the murine paralog of human Siglec-10

Structure and function
Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).

Gene family summary
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]

References

Further reading

SIGLEC


Tom or Thomas Croft may refer to:

Sports
 Thomas Croft Buck (born 1970), Danish lightweight rower
 Tom Croft (born 1985), English rugby union player
 Thomas "Tucker" Croft (died 1955), Irish footballer

Others
 Thomas Croft (MP) for Ludlow (UK Parliament constituency)
 Tommy Croft, comedian in Jollyboat (comedy act)
 Sir Thomas Elmsley Croft, 7th Baronet (1798–1835), of the Croft baronets
 Sir Thomas Stephen Hutton Croft, 6th Baronet (born 1959), of the Croft baronets

See also
 Thomas Crofts, British bibliophile, Anglican priest, Fellow of the Royal Society and European traveller


A professional network service (or, in an Internet context, simply a professional network) is a type of social network service that focuses on interactions and relationships for business opportunities and career growth, with less emphasis on activities in personal life.

A professional network service is used by working individuals, job-seekers, and businesses to establish and maintain professional contacts, to find work or hire employees, share professional achievements, sell or promote services, and stay up-to-date with industry news and trends. According to LinkedIn managing director Clifford Rosenberg in an interview with AAP in 2010, "[t]his is a call to action for professionals to re-address their use of social networks and begin to reap as many rewards from networking professionally as they do personally." Businesses mostly depend on resources and information outside the company and to get what they need, they need to reach out and professionally network with others, such as employees or clients as well as potential opportunities.

"Nardi, Whittaker, and Schwarz (2002) point out three main tasks that they believe networkers need to attend to keep a successful professional (intentional) network:
building a network, maintaining the network, and activating selected contacts. They stress that networkers need to continue to add new contacts to their network to access as many resources as possible and to maintain their network by staying in touch with their contacts. This is so that the contacts are easy to activate when the networker has work that needs to be done."

By using a professional network service, businesses can keep all of their networks up-to-date, and in order, and helps figure out the best way to efficiently get in touch with each of them. A service that can do all that helps relieve some of the stress when trying to get things done.

Not all professional network services are online sites that help promote a business. Some services connect the user to other services that help promote the business other than online sites, such as phone/Internet companies that provide services and companies that specifically are designed to do all of the promoting, online and in person, for a business.

History
In 1997, professional network services started up throughout the world and continue to grow. The first recognizable site to combine all features, such as creating profiles, adding friends, and searching for friends, was SixDegrees.com. According to Boyd and Ellison's article, "Social Network Sites: Definition, History, and Scholarship", from 1997 to 2001, several community tools began supporting various combinations of profiles and publicly articulated Friends. Boyd and Ellison go on to say that the next wave began with Ryze.com in 2001. It was introduced as a new way "to help people leverage their business networks".

Inside the works
Quite a lot of work is put into a professional network service, such as the number of hours that go into them and the type of people they work for, as well as the business model of it all, such as the professional interaction and the multiple services they deal with.

Types of services
Some professional network services not only help promote the business but can also help in connecting to other people. Those services may include a specific phone and/or Internet company or a company that helps to connect with other businesses. According to the Society for New Communications Research (SNCR), there are at least nine online professional networks that are being used.

Professional interaction
Kaplan and Haenlein go on to discuss the five points about using media for companies. They say you need to choose carefully, pick the application or make your own, ensure activity alignment, integrate a media plan, and allow access for all.

Choose carefully
"Choosing the right medium for any given purpose depends on the target group to be reached and the message to be communicated. On one hand, each Social Media application usually attracts a certain group of people, and firms should be active wherever their customers are present. On the other hand, there may be situations whereby certain features are necessary to ensure effective communication, and these features are only offered by one specific application."

Ensure activity alignment
"Sometimes you may decide to rely on various Social Media, or a set of different applications within the same group, to have the largest possible reach." "Using different contact channels can be a worthwhile and profitable strategy." According to the Society for New Communications Research at Harvard University, "the average professional belongs to 3-5 online networks for business use, and LinkedIn, Facebook, and Twitter are among the top used."

Integrate a media plan
Social media and traditional media are "both part of the same: your corporate image" in the customers' eyes.

Allow access to all
"...once the firm has decided to utilize Social Media applications, it is worth checking that all employees may access them." According to the SNCR, "the convergence of Internet, mobile, and social media has taken significant shape as professionals rely on anywhere access to information, relationships, and networks."

Online usage
"Half of the respondents report participating in 3 to 5 online professional networks. Another three in ten participate in 6 or more professional networks." "Popular social networks are now being used frequently as Professional Communities. More than nine in ten respondents indicated that they use LinkedIn and half reported using Facebook. Twitter and blogs were frequently listed as 'professional networks'."

Business model
According to Michael Rappa's article, Business models on the Web", "a business model is the method of doing business by which a company can sustain itself – that is, generate revenue. The business model spells out how a company makes money by specifying where it is positioned in the value chain." Rappa mentions that there are at least nine basic categories from which a business model can be separated. Those categories are a brokerage, advertising, infomediary, merchant, manufacturer, affiliate, community, subscription, and utility. "...a firm may combine several different models as part of its overall Internet business strategy." At first, Flickr started as a way to mainstream public relations.

Social impact
When it comes to the social impact that professional network services have on today's society, it has proved to increase activity. According to the SNCR, "[t]hree quarters of respondents rely on professional networks to support business decisions. Reliance has increased for essentially all respondents over the past three years. Younger (20–35) and older professionals (55+) are more active users of social tools than middle-aged professionals. More people are collaborating outside their company wall than within their organizational intranet."

Limitations
Since the internet and social media are a part of this "world where consumers can speak so freely with each other and businesses have increasingly less control over the information available about them in cyberspace", most firms and businesses are uncomfortable with all the freedom. According to Kaplan and Haenlein's article, "Users of the world, unite! The challenges and opportunities of Social Media", businesses are pushed aside and are only able to sit back and watch as their customers publicly post comments, which may or may not be well-written.

See also
Business networking
Career-oriented social networking market
Employment website
Freelance marketplace
Social network service
List of social networking websites
Social media
User-generated content
Web 2.0
Social networking sites
Smart contract: can be used in employment contracts
Virtual worlds

Notes and references

Social media]
Business terms
Professional networks


Villeneuve (; ) is a commune in the Alpes-de-Haute-Provence department in southeastern France.

Villeneuve is located in Durance valley. This village, like many other villages in Provence, is built on the top of a hill to keep it protected from invaders. Villeneuve in French mean "New town" but was constructed in Middle Ages, originally further in the forest on the top of a high cliff. Only the little chapel remains on the rock to show where the original village was located.

Population

See also
 Coteaux de Pierrevert AOC
 Luberon

References

Communes of Alpes-de-Haute-Provence
Alpes-de-Haute-Provence communes articles needing translation from French Wikipedia


The Natural History Museum of Erfurt () is a natural history museum in Erfurt, Germany.

The museum has a permanent exhibition relating the natural history of the forests, fields, city and the geological history of Thuringia. There is also a special exhibitions programme. The museum has collections of botany, zoology, mineralogy — 6,500 specimens presented by Godehard Schwethelm (1899–1992) — and palaeontology. The statutory goals of the museum are the promotion of scientific research and education, the care of scientific collections and hosting scientific meetings.

See also
List of museums in Germany
List of natural history museums

External links

Museums in Erfurt
History of Thuringia
Erfurt


LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene.

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined.

References

Further reading


Nordby Station is a railway station located two kilometers north of Jessheim in Ullensaker, Norway on the Trunk Line. The station was built in 1932 and is served by the Oslo Commuter Rail R13 from Drammen via Oslo S to Dal.

External links
 Jernbaneverket's entry on Nordby Station in English

Railway stations on the Trunk Line
Railway stations in Ullensaker
Railway stations opened in 1932
1932 establishments in Norway
Railway stations in Norway opened in the 1930s


The following article presents a summary of the 1911 football (soccer) season in Brazil, which was the 10th season of competitive football in the country.

Campeonato Paulista

Final Standings

São Paulo Athletic declared as the Campeonato Paulista champions.

State championship champions

Interstate championship champions

In 1911, the first interstate competition was held, between the 1910 São Paulo and Rio de Janeiro state champions:

References

 Brazilian competitions at RSSSF

Seasons in Brazilian football
Brazil


Gus J. Kefurt (1917 – December 25, 1944) was a United States Army soldier and a recipient of the United States military's highest decoration—the Medal of Honor—for his actions in World War II.

Kefurt joined the Army from Youngstown, Ohio in August 1943, and by December 23, 1944, was serving as a staff sergeant in Company K, 15th Infantry Regiment, 3rd Infantry Division. On that day and the next, he led his men in a fight against German forces near Bennwihr, France. He exposed himself to hostile fire in order to encourage his men and direct their fire, led his men in the defense of positions despite repeated enemy attacks, and refused medical evacuation even after being seriously wounded. He was killed on December 25, and posthumously awarded the Medal of Honor in 1948 for his actions during the battle.

Kefurt was buried at the Epinal American Cemetery and Memorial in Épinal, France.

Upon re-stationing to Fort Benning in 1996, 3rd Brigade – 3rd Infantry Division designated building 9001 on Kelley Hill as the Kefurt Fitness Center.

Medal of Honor citation
Staff Sergeant Kefurt's official Medal of Honor citation reads:
He distinguished himself by conspicuous gallantry and intrepidity above and beyond the call of duty on 23 and 24 December 1944, near Bennwihr, France. Early in the attack S/Sgt. Kefurt jumped through an opening in a wall to be confronted by about 15 Germans. Although outnumbered he opened fire, killing 10 and capturing the others. During a seesaw battle which developed he effectively adjusted artillery fire on an enemy tank close to his position although exposed to small arms fire. When night fell he maintained a 3-man outpost in the center of the town in the middle of the German positions and successfully fought off several hostile patrols attempting to penetrate our lines. Assuming command of his platoon the following morning he led it in hand-to-hand fighting through the town until blocked by a tank. Using rifle grenades he forced surrender of its crew and some supporting infantry. He then continued his attack from house to house against heavy machinegun and rifle fire. Advancing against a strongpoint that was holding up the company, his platoon was subjected to a strong counterattack and infiltration to its rear. Suffering heavy casualties in their exposed position the men remained there due to S/Sgt. Kefurt's personal example of bravery, determination and leadership. He constantly exposed himself to fire by going from man to man to direct fire. During this time he killed approximately 15 of the enemy at close range. Although severely wounded in the leg he refused first aid and immediately resumed fighting. When the forces to his rear were pushed back 3 hours later, he refused to be evacuated, but, during several more counterattacks moved painfully about under intense small arms and mortar fire, stiffening the resistance of his platoon by encouraging individual men and by his own fire until he was killed. As a result of S/Sgt. Kefurt's gallantry the position was maintained.

See also

 List of Medal of Honor recipients
 List of Medal of Honor recipients for World War II

References

1944 deaths
United States Army personnel killed in World War II
United States Army Medal of Honor recipients
United States Army soldiers
Recipients of the Silver Star
1917 births
World War II recipients of the Medal of Honor
People from Greenville, Pennsylvania


KAMA (750 AM) is a radio station broadcasting a Spanish news/talk/music format. Licensed to El Paso, Texas, United States, the station serves the El Paso area. The station is currently owned by 97.5 Licensee TX, LLC, an American subsidiary of Grupo Radio Centro.

The nighttime signal of KAMA reduces power to 1 kilowatt and becomes highly directional to the west in order to protect the skywave signal of WSB in Atlanta.  750 AM is a United States and Canadian clear-channel frequency; WSB is a Class A dominant station on this frequency.  CBGY is the Canadian Class A station on 750 AM.

History
The station went on the air as KEPB on April 18, 1985, promptly taking the current KAMA calls on July 11. It took over the intellectual property of KAMA, which had been at 1060 (later KXPL) and aired a Spanish-language format with a heritage stretching to Juárez's XELO-AM. The move to 750 allowed KAMA to stop being a daytimer and created a new station, KFNA, at 1060.

The station was sold to Tichenor Media, operator of longtime rival KBNA, in 1994. Tichenor merged into Heftel Broadcasting in 1997, changed name to Hispanic Broadcasting Corp in 2000, and merged into Univision Communications in 2003.

For a time, beginning in 2012, KAMA was the El Paso outlet for the Univision America talk network, a format later moved to sister KQBU at 920 AM.

In 2016, Univision Radio exited El Paso by selling its stations to affiliates of Mexican radio broadcaster Grupo Radio Centro for $2 million, with GRC taking over operations via LMA on November 8. Rafael Márquez, a United States citizen, owns 75 percent of the licensee, 97.5 Licensee TX, LLC, with the remainder being owned by Grupo Radio Centro TX, LLC.

References

External links

AMA
Radio stations established in 1985
AMA
News and talk radio stations in the United States
Grupo Radio Centro
1985 establishments in Texas


This is the complete episode listing for the anime adaptation of the visual novel Soul Link. The 12-episode series was animated by Picture Magic, with music composed by Hiroyuki Sawano.

List of episodes

Theme songs
Opening
"Screaming" by Miyuki Hashimoto

Ending
"Dust Trail" by Miyuki Hashimoto

References

Lists of anime episodes


Aspremont () is a commune in the Hautes-Alpes department in southeastern France.

Population

See also
Communes of the Hautes-Alpes department

References

Communes of Hautes-Alpes
Dauphiné


The 2007–08 A1 Grand Prix of Nations, Australia is an A1 Grand Prix race held on 3 February 2008 at the Eastern Creek Raceway in Sydney, Australia. This was the sixth race in the 2007–08 A1 Grand Prix season.

Pre-race
Fairuz Fauzy who drove in the inaugural 2005–06 season replace this weekend Alex Yoong in the A1 Team Malaysia car. Yoong had the longest run of consecutive starts with 45 successive starts.

For his home race, A1 Team Australia renamed its cars as Jackaroo. The name was chosen between the Australian symbol propositions done by fan in the official team site.

Since Taupo round, A1GP cars used a 30 per cent biofuel mix. A1 Grand Prix continued its environmental campaign in Australia using electric generators for all the paddock's temporary and ancillary structures provided by Active Power Management and initiated by THINK Greener Racing.

Qualifications
Once again, the practice sessions were dominated by France in Friday wet and Saturday humid weather conditions.

On Friday night, Portugal practice their pit stops and a tyre gun hose that became disconnected hit accidentally the leg of James Goodfield, the race engeener of the next door garage, Great Britain. James Goodfield sustain a broken leg and was carry up to the hospital.

Chris Alajajian, driver of the Lebanon, made a mistake on his first out lap for Sprint race qualifying spinning and hitting the tyre barriers at Turn 5. The car was too much damaged to complete a flying lap during qualifying sessions. Lebanon after hard work to repair the car during the night, started both the Sunday races from the last grid position.

Canada was penalised because its driver, Robert Wickens, did not respect blue flags during the feature race qualifying, hampering Sérgio Jimenez (Brazil). Robert Wickens lost his 8th qualifying position to 21st.

 (1) = No time for A1 Team Lebanon due to crash during Sprint qualifying.
 (2) = A1 Team Canada was penalised for blue flag disrecpet, losing its 8th position.

Sprint race
This race is known as 'the race of two-halves' due to the track being dry in the first half with 27 °C, then become extremely difficult and wet. In first lap, the order is France, Switzerland, South Africa, New Zealand, Great Britain with a great start from the 8th, China, Germany and USA. Pakistan crash out in the first lap. Loïc Duval (France) made the fastest lap in Lap 2 and is pulling away.
In lap 7, the rain start and Adrian Zaugg (South Africa) is slipping down at Turn 1. Narain Karthikeyan (India) is going off too. Great Britain and Indonesia enter into the pits for wet tyres in lap 9. Cong Fu Cheng (China) spins off in Lap 10, Adam Carroll (Ireland) the next lap.
Robert Wickens (Canada) made an amazing race. He passes Ireland and Netherlands in Lap 11 takink 7th. At Turn 1, next lap, it grabs the 4th position passing four cars including Germany. One lap before the end of the Sprint race, France is leading followed by New Zealand, Switzerland, Canada, Germany, USA, Australia and South Africa.
Neel Jani (Switzerland) spin in the final lap. Loïc Duval (France) in his final round of racing for this A1GP season due to commitments in Japan, converted his pole position with a very comfortable win and breaking the 37-race win-drought, when France was a dominant team in A1GP's debut season. The final standing is France, New Zealand, Canada taking advantage of the rain and took a chance on not switching for wet tyre to climb from 15th, Germany, USA, Australia, South Africa, Brazil, Netherlands and Switzerland in 10th.

Main race
It's 25 °C and soaking wet for the Main race. Jonny Reid (New Zealand), having qualified pole, halt on track after quitting the stand and must start the race from the pitlane. Loïc Duval (France), qualified fifth, is stuck on the grid at the start of the formation lap and must start the race second to last.
After the first lap, Ireland and India enter in pit to change their slicks tyres to wets. The order is Switzerland, Great Britain, South Africa, Brazil, USA, China, Germany, Czech Republic, Netherlands, and Canada. In the third lap, New Zealand is 19th and France 14th. Robert Wickens (Canada) grab the 9th to Tomáš Enge (Czech Republic) in Lap 3. In lap 7, New Zealand is already 14th and France in points at 10th. During Lap 9, Pakistan run off without damage. In the next lap, João Urbano (Portugal) spin off trying passes Chris Alajajian (Lebanon) who run off too. Pakistan, Czech Republic and China receive a drive-through penalty for making a false start. The pit window is now open in Lap 10.
Switzerland and Great Britain pit at same time and leave the stand in the same order. In Lap 13, South Africa leads France by 21 seconds but neither have made their pit stop. Adrian Zaugg (South Africa) take the lead after a quick pit stop in Lap 15. In the same lap, Robbie Kerr (Great Britain) run wide and lost a few seconds meanwhile Jonathan Summerton (USA) has gone off and Robert Wickens (Canada) passes. Finally, France makes is mandatory pit stop and South Africa set the current fastest lap in Lap 16.
After the pit window close, Canada and USA fight for 6th in Lap 17. Loïc Duval (France) join the battle and try to passes Jonathan Summerton (USA). In Lap 22, France hit USA, who give up, and receive a drive-through penalty for avoidable collision. Two laps before the opening of the pit for the second mandatories stops in Lap 26, John Martin (Australia) passes Robert Wickens (Canada).
Cong Fu Cheng (China) loses is 11th to 13th after spin in Lap 28, Satrio Hermanto spin also at turn 1, 2 laps after that. Switzerland takes the fasted lap. During his pit stop on lap 31, the French car have a clutch failure and Loïc Duval must renounce. Canada passes Germany for 6th and South Africa takes again the fasted lap on Lap 33. Later, Cong Fu Cheng (China) passes Narain Karthikeyan (India) fot 10th.
The 42nd lap is the last and South Africa win 19.560 seconds behind Switzerland, Great Britain, Brazil, Australia, Canada, Germany, Netherlands, New Zealand and China. New Zealand and France are now tied leading the championship with 96 points.

After race
Due to commitment to race in Japan (Formula Nippon and Super GT) agreed before the start of the A1GP season, Loïc Duval announced he will not drive for France for the final three rounds of the 2007–08. His participation for the next South African round on 24 February was only confirmed 22 February.

Notes
 It was the 28th race weekend (56 starts).
 It was the third venue in Eastern Creek Raceway and in Australia.
 It was the first race weekend for Jonathan Cochet and Michael Klein.
Records :
 France even up the 6 pole position of Switzerland.
 France score 10 fastest laps (6 rewarded by points).
 Lebanon participate on 28 rounds (56 starts) without won points since their first Grand Prix.
 Neel Jani score 232 points.

References

External links
France wins Australia Sprint
Sprint race: lap-by-lap
Sprint Race Results
South Africa storms Sydney
Feature race lap-by-lap
Feature Race Results

A1 Grand Prix of Nations, Australia, 2007-08
A1 Grand Prix of Nations, Australia, 2007-08
Motorsport at Eastern Creek Raceway


CCNF may also mean Canonical conjunctive normal form in Boolean algebra.

G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene.

Function

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which are part of the ubiquitin-proteosome system (UPS). The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.

Discovery and gene/protein characteristics
CCNF gene was first discovered in 1994 by the Elledge laboratory while experimenting with Saccharomyces cerevisiae. At the same time, the Frischauf laboratory also identified cyclin F as a new cyclin during their search for new candidate genes for polycystic kidney. CCNF gene has 17 exons and is located at position 16p13.3 on the human chromosome. Its protein, cyclin F, is made up of 786 amino acids and has a predicted molecular weight of 87 kDa. Cyclin F is the main member of the F-box protein family, which has about 40 amino acid motif, forming the F-box.

Cyclin F most closely resembles cyclin A in terms of sequence and expression patterns. Moreover, it has additional shared features of cyclins, such as pEST region, protein quantity, localization, cell cycle-regulated mRNA, and ability to influence cell cycle and progression.  Cyclin F differs from other cyclins by its ability to monitor and regulate cell cycle without the need for cyclin-dependent kinases (CDKs). Instead, the Pagano laboratory found that cyclin F is the substrate receptor of an SCF ubiquitin ligase that ubiquitinates and directly interacts with downstream targets, such as CP110 and RRM2, through its hydrophobic patch.

Expression patterns
Cyclin F mRNA is expressed in all human tissues, but at different quantities. It is found most abundantly in the nucleus, and the quantity levels vary during the different stages of cell cycle. Its expression pattern closely resembles the one from cyclin A. Cyclin F levels begin to rise during S phase and reaches its peak during G2.

Role
Cyclin F interacts with other proteins that are important for centrosomal duplication, gene transcription, and DNA synthesis, stability and repair.

RRM2
RRM2 is a ribonucleotide reductase (RNR), an enzyme responsible for the conversion of ribonucleotides into dNTPs. dNTPs are essential for DNA synthesis during DNA replication and repair. Cyclin F interacts with RRM2 to control the production of dNTPs in the cell to avoid genomic instability and frequency of mutations.

CP110
Moreover, cyclin F located at the centrosomes are needed to regulate levels of CP110, a protein involved in centrosome duplication. The regulation of CP110 during G2, through ubiquitin mediated proteolysis, helps to prevent mitotic aberrations. by allowing only one centrosome replication per cell cycle.

NuSAP
NuSAP is a substrate of cyclin F that is involved in cell division. It is a microtubule-associated protein that is required for the spindle assembly process. Its function is to interact with microtubules and chromatin to create stabilization and cross-linking. A lack of NuSAP has been linked with an increase in mutations due to impaired chromosome alignment during metaphase, while an excess of NuSAP leads to mitotic arrest and microtubule bundling. Cyclin F help to control NUSAP abundance and is therefore essential to proper cell division.

SLBP
SLBP is a protein that controls the mRNAs encoding canonical histones and H2A.X, thereby synchronizing histone metabolism with the cell cycle. In the G2 phase of the cell cycle, SLBP is degraded via cyclin F to control H2A.X levels after genotoxic stress.

E2F1, E2F2, and E2F3A
E2F1, E2F2, and E2F3A are the three canonical activators of the E2F family of transcription factors. During G2, cyclin F targets all three activator E2Fs for degradation, thereby turning off a main cell-cycle transcriptional engine.

Clinical significance

Neurodegenerative diseases
CCNF mutations have more recently been associated to neurodegenerative diseases such as frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and co-morbid ALS-FTD. Whole-genome linkage analysis and genome sequencing identified CCNF to be linked to both familial and sporadic ALS patients. In vitro and in vivo studies using ALS-linked mutations in CCNF were also carried out. It was found that certain CCNF mutations caused increased ubiquitylation activity of cyclin F  leading to abnormal ubiquitylation of proteins. In zebrafish, mutant CCNF fish showed motor neuron axonopathy and reduced motor response. ALS/FTD patient induced pluripotent stem cell -derived motor neurons expressing endogenous mutant CCNF had increased ubiquitylated proteins, likely decreasing the available free ubiquitin pool, which is essential for the protein degradation pathways that remove protein waste from motor neurons.

Cancer
Cyclin F has a tumor suppressor role because normal expression is involved in cell cycle regulation by inducing G2 arrest and preventing mitosis. Moreover, cyclin F through RRM2 and CP110 control centrosome duplication and reduce the frequency of genomic mutations. So far, mutations in CCNF and increased RRM2 expression have been identified in several human cancers.

References

Further reading

External links


Tiit Rosenberg (born 26 December 1946, in Tsirguliina) is an Estonian historian and professor of Estonian History in University of Tartu. In 1996–2008 was he also chairman of Õpetatud Eesti Selts (The Learned Estonian Society).

Rosenberg studies history of agriculture in 19th Century and also Estonian historiography.

References

1946 births
Living people
People from Valga Parish
20th-century Estonian historians
Historians of Estonia
Academic staff of the University of Tartu
Recipients of the Order of the White Star, 4th Class
21st-century Estonian historians


Corporate appointeeship is the name given in the UK to the process of an accredited organisation becoming the designated appointee to a person who is unable to manage their own finances. Corporate appointees are often local authorities in the UK and firms of solicitors or consumer advocate organisations that provide an appointeeship service when a suitable family member or friend is unavailable or lacking to take over the daily money management services and responsibilities of the person in need of an appointee.

Corporate appointees need to be approved by the Department for Work and Pensions as the appointee is responsible for receiving benefit entitlement payments on behalf of the individual representing. Corporate appointee services have been extended by the Money Carer Foundation that have served to highlight the lack of financial protection that often leads to the financial abuse of vulnerable individuals unable to manage their finances.

External links
 DWP appointeeship information
 Appointeeship and financial abuse reference point

Accounting in the United Kingdom


Hazaribagh () is a Thana of Dhaka District in the Division of Dhaka, Bangladesh. Hazaribagh is part of Old Town, Dhaka, Bangladesh. 95% of Bangladesh's tanneries, which is where animal skins are processed to make leather, were located in or around Hazaribagh before they moved to Hemayatpur, Savar. In Hazaribagh, traditional establishments, culture, language and food can be found in daily life practices. Owing to its location near Buriganga River, Hazaribagh shares significant history as well. It is one of the most densely populated places on earth, though it is criticised for its low living standards.

Geography
Hazaribagh is located at . Its total area is 3.58 km2.

Demographics
This Hazaribagh has a population of 75,458. Males constitute 58.67% of the population, and females 41.33%. Hazaribagh has an average literacy rate of 53.67%, and the national average of 32.4% literate.

Administration
Hazaribagh has 3  Unions/Wards, 15 Mauzas/Mahallas, and 1 village.

Hazaribag Girls' School and College (1971)
 Moneshwar Government Primary School (1964)
 Mukulika High School (1981)
 Shahid Sheikh Rasel Government High School (2011)
Saleha School And College
Gojmohal Tannery High School (1988)
Institute of Leather Engineering and Technology, University of Dhaka . This is an Institute of the Dhaka University since 2011, It has contain 3 department of Unit-A of Dhaka University.

See also
 Upazilas of Bangladesh
 Districts of Bangladesh
 Divisions of Bangladesh

References

Old Dhaka
Thanas of Dhaka


The Royal St. George Yacht Club is a yacht club housed in a Victorian clubhouse, located in Dún Laoghaire, Ireland. Each season the Club hosts a number of national and international sailing events.

It is home to the Dublin University Boat Club of Trinity College, Dublin.

History
The 'Royal St. George Yacht Club' was founded by members of the Pembroke Rowing Club in 1838. Initially it was known as 'Kingstown Boat Club.' By 1845 royal patronage had been obtained and the club became 'Royal Kingstown Yacht Club.'
This patronage permitted members to fly a red ensign with white cross and crown in the centre. In 1847 the club was permitted to change its name to 'Royal St. George Yacht Club.' In 2013 the club celebrated its 175th birthday with a series of historical talks and sailing events.

Buildings

The committee was not in a position to build a clubhouse until 1841. The clubhouse was designed in 1842 and completed in 1843 adjoining the 'Watering Pier'. It consisted of a single storey building (from the street side) designed by architect John Skipton Mulvany, with a plastered Ionic portico forming a breakfront with two windows on each side. Accommodation at street level consisted of an entrance hall, ballroom, committee room, staircase to the boathouse below and lavatories. A terrace overlooked the harbour. The painted exterior was coloured to look like stone.

In 1843 the Club employed architect George Papworth to extend the clubhouse on the west side. A Mr. Masterson was the builder of the extension, which cost £1,500. Papworth's proposal was unique. He built a new portico exactly matching the one which already existed, and formed a colonnade of paired columns linking the two porticos. The entrance was moved west from the portico to this new colonnade. The extension contained a reading room with a bow front facing the harbour. At this time all of the small paned windows were replaced with plate glass.

In 1866 architect Mr. E.T. Owen was appointed to provide an extension to be used as a smoking room on the east side of the building, at a cost of £1,316.

In 1919 a fire destroyed all but four rooms of the clubhouse. Mr. Bradbury oversaw the rebuilding works and Pemberton & Sons undertook the building works, which cost £2,550.
In the 2000s architect Michael Collins provided a copper faced extension on the east side of the clubhouse. It does not extend up to street level and maintains a view of the harbour to those walking past.

Racing
Much of the club activities in summer involve sailing events.

Sunday: Family boating.

Monday: Special Needs sailors.

Tuesday: D.B.S.C. Dinghy racing.

Wednesday: Water Wag racing.

Thursday: D.B.S.C. Keelboat racing.

Saturday: D.B.S.C. keelboat and dinghy racing.

Fleet
Currently the most popular boats raced in the club are:

IRC keelboat classes

One-Design keelboat classes: Dragon (keelboat), Shipman 28s, Ruffians, SB20s, Squibs, J80

Dinghy classes: Water Wag, Laser, RS200, RS400

Junior Classes: 420, Optimist, Laser

The club has a large group of non-racing cruising yacht types. The club also owns a small fleet of 1720s and J80s.

Heritage wooden boats sailed in the club include Glens, Water Wags and IDRA 14s. The Water Wags are the oldest One-Design dinghy class in the world.

References

External links

Royal yacht clubs
Yacht clubs in Ireland
Organisations based in the Republic of Ireland with royal patronage
Water sports in County Dublin
1838 establishments in Ireland


Isidro Márquez Espinoza (born May 14, 1965) is a Mexican former professional baseball pitcher. He played in Major League Baseball (MLB) for the Chicago White Sox.

Career
Márquez played during one season at the major league level for the Chicago White Sox. He was purchased by the Los Angeles Dodgers from the Mexican League's Tuneros de San Luis in 1988. Márquez played his first professional season (in American baseball) with their Class A-Advanced Bakersfield Dodgers in 1988, and his last affiliated season with the White Sox and their Triple-A Nashville Sounds in 1995.

In 2000, he made a comeback with the Piratas de Campeche of the Mexican League. He pitched in Mexico through 2011.

In 2020, Márquez was inducted into the Mexican Professional Baseball Hall of Fame.

In 2021, the Piratas retired Márquez's 33 number. On 30 October 2022, the Águilas de Mexicali also retired Márquez's 33 number.

References

External links

1965 births
Living people
Águilas de Mexicali players
Albuquerque Dukes players
Alijadores de Tampico players
Bakersfield Dodgers players
Baseball players from Sonora
Broncos de Reynosa players
Chicago White Sox players
Major League Baseball pitchers
Major League Baseball players from Mexico
Mayos de Navojoa players
Mexican expatriate baseball players in the United States
Mexican Baseball Hall of Fame inductees
Mexican League baseball pitchers
Nashville Sounds players
Olmecas de Tabasco players
Petroleros de Minatitlán players
Piratas de Campeche players
Rojos del Águila de Veracruz players
San Antonio Missions players
Tigres del México players
Tuneros de San Luis Potosí players
People from Navojoa


Events from the year 1510 in Ireland.

Incumbent
Lord: Henry VIII

Events
An Anglo-Irish army led by Gerald Mór FitzGerald, the 8th earl of Kildare, marches on Thomond, and is met and defeated at Cratloe by an army of the O'Brien, McNamara, Sil-Aedha and Clanrickard clans led by Turlough O'Brien.

References

Ireland
Years of the 16th century in Ireland


Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene.

Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.

Interactions

CCNG2 has been shown to interact with PPP2CA.

References

External links

Further reading


Topo Soft was a Spanish software house for 8-bit home computers that emerged during the eighties. They were part of the golden era of Spanish software. It dissolved in 1994 due to economic problems related with the late arrival of 16-bit computers in Spain. Some of its workers founded Pyro Studios in 1998. However, there are also criticisms, and in 2019 Eugenio Barahona and Cancho acknowledged that sometimes the planning to produce a certain amount of video games affected the quality, leaving no time to "finish them off in conditions, or simply test them in order to balance their playability before releasing them for sale".

The eighties, 8-bits
Topo Soft published multiple games for the MSX and PC such as Survivor, Stardust, Gremlins 2: The New Batch, and Desperado (published in England as Gun.Smoke) .

16-bits
 Quickit, a graphical system to handle MS-DOS

References

External links
Topo Soft at mobygames.com
Topo Soft advertisements at amstrad.es

Defunct video game companies of Spain
Video game companies disestablished in 1994
1994 disestablishments in Spain


Hauerseter Station is a railway station located at Hauerseter in Ullensaker, Norway on the Trunk Line. The station was opened in 1894 and is served by commuter train R13 from Drammen via Oslo Central Station to Dal.

From 1947 until the construction of Gardermoen Line and Oslo Airport, Gardermoen in the 1990s, Hauerseter was the terminal station of the Hauerseter–Gardermoen Line, a branch line that went to Gardermoen Air Station.

External links

  Entry at Norwegian National Rail Administration

Railway stations on the Trunk Line
Railway stations in Ullensaker
Railway stations opened in 1894
1894 establishments in Norway
Railway stations in Norway opened in the 1890s


The neighborhoods of Beersheba refer to urban and residential districts in the city of Beersheba, Israel.

Old City

The Old City (, HaIr HaAtika)
(
(al balad alqafima) is the historical center of Beersheba. Based on the core of the old Ottoman-era built town, it was expanded by the British during the Mandate era. Street signs in English from the Mandate era are still visible on many street corners. Laid out in a grid pattern, it consists mostly of one- and two-floor stone buildings, although some taller buildings were recently built. The old Turkish buildings dating back about 100 years are mostly in a state of neglect although some exceptions can be found where private individuals or organizations have renovated them. Until the late 1990s, the Old City was the commercial hub of Beersheba. But since the opening of the large Negev Mall near the Central Bus Station (and a number of smaller neighborhood-malls) many of the leading chain stores have moved out. There are several sites of historical interest in the Old City: Abraham's Well, the Negev Museum of Art, Allenby Garden, Turkish Railway Station, British War Cemetery, and Aljama Mosque.

Alef

Alef (, lit. A or 1) is located to the immediate north of the Old City. It was the first neighborhood built after Israeli independence (in the 1950s) and provided housing for immigrants from Morocco, Iraq, Yemen and India. Shechuna Alef consists of rows of semi-detached houses and a few apartment blocks.

Bet

Bet (, lit. B or 2) is located northwest of Alef. It was also built in the 1950s, and provided housing for immigrants from Poland, Egypt, and later Libya (1960s) Georgia and Russia (1970s). Shechuna Bet is home to the Vasermil Stadium, home of Hapoel Be'er Sheva, the city's major football club.

Gimmel
Gimmel (, lit. G or 3, also known as Hashalom) is northeast of the Old City. Soroka Medical Center and Ben-Gurion University of the Negev are located here. Many students live in the neighborhood and the university dormitories are situated here.  It consists largely of apartment blocks.

Dalet
Dalet (, lit. D or 4) is located north of Bet and west of Gimmel, south west to Ramot and northeast to Nahal Ashan. The neighborhood  holds the Kaye Academic College of Education, a few dozen community centers, the Nurit immigrant integration camp, a psychiatric hospital, two major shopping centers (Gilat and Oren). The neighborhood holds the famous pyramid house.

Dalet Mizrah
The newest part of Dalet neighborhood (also known Vav haYeshana) where Ben Gurion University is located.

Hei
Hei (, lit. H or 5) is located northwest of the Old City, and west of Alef and Bet. It houses the Ye'elim Absorption Center.

Vav
Vav (, lit. V or 6) is located in the northwest of the city, north of Bet and west of Daled. It consists of a combination of apartment blocks and private homes, and has its own shopping mall (Kanyon Avia). The old Vav neighborhood, also known as Ringelblum, is popular with students due to its proximity to the university.

Tet
Tet (, lit. T or 9) is located to the west of the Old City. It consists almost entirely of tower blocks.

Yud Alef
Yud Alef (, lit. JA 11) is located to the west of Tet. Most of the homes are detached or semi-detached. The neighborhood includes the Australian Soldier Park.

Nahal Ashan

Nahal Ashan (, Smoke River, Ashan River), also known as Neve Menachem (, Menachem Oasis) is the westernmost neighborhood in Beersheba. It was built in the past decade and consists largely of private homes. The Neighberhood is built south west of the Ashan River (Nahal Ashan) and Ashan Riven is named after the biblical Ashan city in the Judea region.

Nahal Beka

Nahal Beka (, Valley Stream) is the city's southernmost neighborhood, located to the southwest of Neve Noy. It was built in the 1990s to house new immigrants from the former Soviet Union, mostly living in caravans and trailer homes. Since then, wealthier members of the Russian Jewish population had moved there and pushed for better services. Sports facilities had been built, and members of the community established the Center of Caucasian Immigrants.

American Jewish philanthropists had inaugurated a program in Nahal Beka to assist new immigrant youth from the Caucasus integrate in Israeli society. Youngsters aged 13–16 took part in a variety of after-school programs together with native-born Israelis that include field trips, leadership workshops and a summer camp.

In 1995 the temporary housing was evacuated and removed. Meanwhile, a neighborhood with single housing was built to the west, carrying the same name.

Neot Lon

Neot Lon () is located in the west of the city, west of Tet. It is built around woodland and consists largely of detached and semi-detached houses. The neighborhood includes the Air Force technical high school and the Country Club.

Neve Noy
Neve Noy (, lit. Beauty oasis) is located directly south of the Old City. It was founded in 1952 as an agricultural settlement consisting of small stone cottages with vegetable gardens, known as Mishkay Ezer (). The first residents were immigrants from Morocco and Tunisia who had been living in ma'abarot (transit camps). It was renamed Neve Noy in 1979, and consists largely of detached two-storey homes. Streets in this neighborhood are named after plants that grow in the Negev, such as  Atad, Shita and Tzabar. Neve Noy is home to the second largest Karaite community in Israel, as well as Maccabi Be'er Sheva, Beersheba's second football team.

Neve Ze'ev
Neve Ze'ev ( is located in the southwest of the city, south of Tet. It consists almost entirely of large tower blocks in an area carved out of the surrounding hillside. Many construction projects are under way.

Ramot

Ramot (, lit. Heights) is the northernmost and easternmost neighborhood in the city, located northern of Gimmel, and named for the fact that it is built on hills. It consists of a mixture of tower blocks and houses, and is still being expanded.

References

Beersheba


Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.

References

Further reading

Solute carrier family


Words taken down is a parliamentary procedure in the United States House of Representatives by which one member requests that another member be sanctioned for remarks that violate decorum. Such remarks can include profanity, personal aspersions against a House member, or references to decisions in the Senate.

The Congressional Research Service summarized the process in the following way:

Martin L. Levine, law professor at the University of Southern California, notes that "Taking down words, like 'taking down names,' is the start and not the end of a process. A separate step is required to rule the words out of order."

A 1999 study by Kathleen Hall Jamieson found that requests to take down words peaked in 1946 and 1995, years before or after control of the House changed hands.

References

United States House of Representatives


Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.

Function

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

FIBP has been shown to interact with FGF1.

References

Further reading


Sigoyer may refer to the following places in France:

 Sigoyer, Alpes-de-Haute-Provence, a commune in the department of Alpes-de-Haute-Provence
 Sigoyer, Hautes-Alpes, a commune in the department of Hautes-Alpes

Other uses
 Sigoyer (grape), an alternative name for the French wine grape Calitor.
 Bouteillan noir, another French wine grape that is also known as Sigoyer.


Cytochrome c oxidase subunit 7A-related protein, mitochondrial is an enzyme that in humans is encoded by the COX7A2L gene.

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.

The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex.

This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence.

This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.

References

Further reading

External links


The Devil Worshippers () is a six-chapter 1921 silent German film written by Marie Luise Droop, directed by Muhsin Ertuğrul and featuring Carl de Vogt in the title-role of Kara Ben Nemsi. De Vogt's career as an actor stretched into the 1960s, where he appeared in a number of the then-popular German crimi films. Later horror-star Béla Lugosi is also featured in one of his first supporting roles in a film, although his precise role in the film is unknown (some sources say he played a character called Pir Kamek).

The film was an adaptation of two Karl May novels (The Desert and Wild Kurdistan). It was one of the first German films to be based on the works of Karl May, who was normally known for his novels set in the old American West).

This film was the first of a trilogy of the production company "Ustad-Film" starring actor Carl de Vogt, but it was only released as the third in the cinemas. In several scenes, this black-and-white film has some coloring, e.g. blue for night scenes.

The film is said to have premiered on 2 January 1921 at "Vaters Lichtspiele" at Würzburg, but the first showing is only documented for 14 January 1921 at Wilhelmsburg. The film is now considered to be lost.

Plot
The film is about a cult of devil worshippers called the Jesidi whose village is destroyed by an army general named Machrej under a religious pretext. When the village leader Kara ben Nemsi sees the devastation and learns that his people have been taken into captivity, he vows revenge. The ben Nemsi character, and his faithful servant Hadschi Halef Omar, appeared later in several other Karl May novels, all set in the Near East.

Cast
 Carl de Vogt as Kara Ben Nemsi
 Meinhart Maur as Hadschi Halef Omar
 Tronier Funder as Officer
 Béla Lugosi as Pir Kamek
 Fred Immler
 Ilya Dubrowski
 Gustav Kirchberg
 Erwin Baron

See also
 Karl May film adaptations
 Béla Lugosi filmography

References

External links

1921 films
1921 lost films
1921 adventure films
German adventure films
German silent feature films
German black-and-white films
Films of the Weimar Republic
Films based on the Orient Cycle
Films directed by Muhsin Ertuğrul
Films set in the 19th century
Lost German films
Lost adventure films
Silent adventure films
1920s German films


This article contains a list of professional snooker referees and indicates those who have officiated at the World Snooker Championship finals. John Williams presided over the most (eleven) finals, nine of those at the Crucible Theatre, including the 1985 final between Dennis Taylor and Steve Davis.

All of the World Snooker Championship finals from the start of what is known as the "modern era" in 1969 are included in the list, with the exception of 1970 and 1971. The referees for these two years are currently not known. Some earlier years have also been included where the information about referees is available.

Lists of referees

Former referees

Current referees

Notes

References

Referees
Snooker


SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.

Interactions
SFRS2IP has been shown to interact with U2AF2.

References

Further reading


WD repeat-containing protein 46 is a protein that in humans is encoded by the WDR46 gene.

References

Further reading


Inferno is the eighth studio album by Swedish death metal band Entombed. It was released on 4 August 2003. The album is a continuation of the sound heard on 2001's Morning Star, and combines traditional death metal with death 'n' roll, along with various other elements and influences.

Track listing

In 2004, Inferno was rereleased by Threeman Records and Candlelight Records with a second disc, titled Averno. It contains the following track listing and content:

Personnel
 Lars-Göran Petrov – vocals
 Uffe Cederlund – guitar
 Alex Hellid – guitar
 Jörgen Sandström – bass
 Peter Stjärnvind – drums

References

Entombed (band) albums
2003 albums


Sigoyer (; ) is a commune in the Hautes-Alpes department in southeastern France.

Population

See also
Communes of the Hautes-Alpes department

References

Communes of Hautes-Alpes


Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.

Interactions
SFRS11 has been shown to interact with U2AF2.

References

Further reading


Ben Oakland (September 24, 1907 – August 26, 1979) was an American composer, lyricist, and pianist, most active from the 1920s through the 1940s.  He composed mainly for Broadway and vaudeville, though he also worked on several Hollywood scores including for the film My Little Chickadee.

Oakland often composed music only, collaborating with lyricists including Oscar Hammerstein II, Bob Russell, Milton Drake, L. Wolfe Gilbert, and Artie Shaw.  Notable compositions include "Java Jive", "I'll Take Romance", and "I'm A Hundred Percent For You".

The two songs that Oakland wrote with Oscar Hammerstein II are "I'll Take Romance" and "A Mist Over the Moon."  The latter, which was written for a 1938 picture called The Lady Objects won Hammerstein and Oakland an Oscar nomination. The former, which was written for a 1937 film starring Grace Moore, won no awards but is frequently performed. June Christy sang it, to an arrangement by Pete Rugolo, on the 1954 album Something Cool. Another popular version at that time was sung by Eydie Gorme on her LP Sincerely Yours, to an arrangement by Sid Feller.

He collaborated with Artie Shaw and Milton Drake on the love song "If It's You" introduced by Tony Martin in the 1941 Marx Brothers' picture The Big Store.

"If I Love Again," which has a lyric by Jack Murray, was performed by Anita O'Day on the 1960 album Incomparable! and by Barbra Streisand in the 1975 film Funny Lady. It was written for the 1933 musical, Hold Your Horses.

The Songwriter's Hall of Fame lists Oakland on their notable (non-inducted) songwriters list, for contributions to the American popular song.

Selected filmography
 Glamour for Sale (1940)
 The Big Store (1941)

References

External links

American male composers
1907 births
1979 deaths
20th-century American composers
20th-century American male musicians


Matrix metalloproteinase-20 (MMP-20) also known as enamel metalloproteinase or enamelysin is an enzyme that in humans is encoded by the MMP20 gene.

Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.

MMP-20, also known as enamelysin, appears to be the only MMP that is tooth-specific and it is expressed by cells of different developmental origin (i.e. epithelial ameloblasts and mesenchymal odontoblasts).

Clinical significance

The human MMP-20 gene contains 10 exons and is part of a cluster of matrix metalloproteinase genes that localize to human chromosome 11q22.3. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. Enamel in the absence of MMP-20 is hypoplastic (thin), contains less mineral (only one-third as much total mineral as wild type), and contains more protein and water. In general, MMP-20 functions in enamel are to cleave enamel matrix proteins at specific cleavage sites.

References

Further reading

External links
 The MEROPS online database for peptidases and their inhibitors: M10.019

Matrix metalloproteinases
EC 3.4.24


John Samuel McConnell (born December 31, 1975) is a former Major League Baseball pitcher. He played during one season at the major league level for the Atlanta Braves.

McConnell attended Ball State University, and in 1996 he played collegiate summer baseball with the Harwich Mariners of the Cape Cod Baseball League.

He was selected by the Pittsburgh Pirates in the 11th round of the 1997 MLB Draft. McConnell played his first professional season with their Single-A Augusta GreenJackets, Single-A Advanced Lynchburg Hillcats, and Double-A Carolina Mudcats in . McConnell was released by the Pirates during spring training , and signed with the Philadelphia Phillies the next day. After one year in the Phillies organization, he signed with the Atlanta Braves on November 12, 2002, and played his last affiliated season for Atlanta's Triple-A Richmond Braves in . His last professional season was with the Somerset Patriots of the independent Atlantic League in .

References

External links

1975 births
Living people
Ball State Cardinals baseball players
Major League Baseball pitchers
Atlanta Braves players
Erie SeaWolves players
Augusta GreenJackets players
Lynchburg Hillcats players
Carolina Mudcats players
Altoona Curve players
Nashville Sounds players
Greenville Braves players
Richmond Braves players
Somerset Patriots players
Harwich Mariners players
Baseball players from Cincinnati


Kinesin light chain 4 is a protein that in humans is encoded by the KLC4 gene.

References

Further reading


José Parra is the name of:
 José Parra (baseball) (born 1972), baseball player from the Dominican Republic
 José Parra (footballer) (1925–2016), Spanish footballer
 José Felipe Parra (1780–1846), Spanish painter
 José Mauricio Parra (born 1990), Venezuelan footballer
 José Miguel Parra (1780–1846), Spanish painter


Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.

Interactions
PHLDB2 has been shown to interact with FLNC.

References

Further reading


FERM domain-containing protein 7 is a protein that in humans is encoded by the FRMD7 gene.

References

External links
 GeneReviews/NIH/NCBI/UW entry on FRMD7-Related Infantile Nystagmus

Further reading


The blue ribbon badge was a symbol of the temperance movement in 19th century North America.

The badge was created by Francis Murphy, 1836–1907, who was a chief advocate of the temperance movement in the United States and abroad in his generation. It was inspired by a Bible verse, Numbers 15:38-39, which says: "Speak unto the children of Israel, and bid them that they make them fringes in the borders of their garments, throughout their generations, and that they put upon the fringe of the borders a ribband of blue : and it shall be unto you for a fringe, that ye may look upon it, and remember all the commandments of the Lord, and do them."

The ribbon was worn by those who agreed with a pledge of abstinence from alcohol consumption as a beverage, as advocated by Francis Murphy. The movement emerged in the northeastern United States during the early 1870s and spread to Canada and Great Britain by the end of the decade. By the mid-1880s, millions had taken the temperance pledge and wore the blue ribbon.

The movement grew out of New England reform clubs. In 1870, Murphy was imprisoned for violating the Maine Law, and when he was released, he began speaking against alcohol and became a leader in reform clubs. He made evangelical Protestantism a central focus of the movement, and also applied evangelical techniques. He spoke in large public halls in a revival-like style encouraging large groups of men to come forward and take the pledge. He focused his speeches on compassion for drunkards, and did not condemn drinkers or the sellers of alcohol.

In 1874, Murphy was invited to Chicago by Frances Elizabeth Caroline Willard, then president of the Women's Christian Temperance Union (WCTU), and Murphy began speaking in the Midwest. Murphy was very successful and the movement expanded into the Midwest. After a speech in Pittsburgh on November 26, 1876, 40,000 residents signed the pledge within ten weeks. Henry J. Heinz was among the Pittsburgh residents who adopted the reform, and the number of saloons in Pittsburgh went from over 1000 in 1877 to les than 100 a few years later. Murphy also worked with John Wanamaker of the WCTU in Philadelphia in 1877, and later traveled to Canada and then to the UK where he met Queen Victoria. D. I. K. Rhine became the figurehead of the Canadian movement, until sexual scandal stalled his progress. William Noble and W. J. Palmer led the movement in the UK.

From 1880 to 1882, the cause of abstinence was revived in Great Britain by the Gospel Temperance or Blue Ribbon movement, based in America. They sent a member named Richard Booth to promote their cause in England through mass meetings held up and down the country. In 1882 and 1883, Rev. M. Baxter edited The Blue Ribbon Official Gazette and Gospel Temperance Herald, a journal dedicated to the Temperance movement. Several clubs of the Blue Ribbon Army and the Gospel Temperance Union established themselves in the British colonies. Booth set off on a highly successful campaign across New Zealand and Australia in 1885. Accompanied by his wife, he often traveled with other temperance evangelists such as Mary Greenleaf Clement Leavitt, the first world missionary of the Woman's Christian Temperance Union.

In 1874, Henry A. Reynolds created the Red Ribbon Reform Club in Bangor, Maine, inspired by the Blue Ribbon Movement.

References

 The Temperance Reform and Its Great Reformers, by W. H. Daniels, 1877.
 The Dundee Weekly Express, January 30, 1882

 Harper's Encyclopædia of United States History from 458 A.D. to 1902, 1901, Harper & Bros.

Footnotes

Ribbon symbolism
Temperance movement
Ribbon badge, blue


Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene. The gene is composed of 6 exons and is
located on human chromosome 17p11.1. This gene is expressed in human brain, lung, kidney and pancreas, and lower expression were also detected in human placenta, liver, thymus, prostate and testis.

Intraflagellar transport (IFT), in which molecular motors and IFT particle proteins participate, is very important in assembling and maintaining many cilia/flagella, such as the motile cilia that drive the swimming of cells and embryos, the nodal cilia that generate left-right asymmetry in vertebrate embryos, and the sensory cilia that detect sensory stimuli in some animals. IFT20 subunit of the particle is localized to the Golgi complex in addition to the basal body and cilia where all previous IFT particle proteins had been found. In living cells, fluorescently tagged IFT20 is highly dynamic and moves between the Golgi complex and the cilium as well as along ciliary microtubules. IFT20 has been shown to interact with SPEF2 in the testis, and plays a role in sperm motility.

References

Further reading


Christoph Schütz (6 November 1689 in Umstadt, Germany - 4 January 1750 in Bad Homburg, Germany) was a pietist writer and a songbook publisher.

Schütz's book, Die Güldene Rose. . . von der Wiederbringung Aller Dinge (The Golden Rose . . . on the Restoration of All Things) influenced George Rapp and his Harmony Society so much at one point that they used the symbol of the rose and the Bible verse Micah 4:8 as the symbol of their communal society for a couple of years.

Radical Pietism
German non-fiction writers
German Christian religious leaders
1689 births
1750 deaths
18th-century Christian mystics
Protestant mystics
German male non-fiction writers


Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.

GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.

Interactions

GADD45GIP1 has been shown to interact with GADD45G, GADD45B and GADD45A.

References

Further reading


Euclid St. Paul's Neighborhood is a residential section of St. Petersburg, Florida which began to be developed in the 1920s in a former orange grove. The neighborhood has a mixture of home styles and sizes, and the Pinellas County Schools headquarters are located there. Bill Freehan, later an all-star catcher for Major League Baseball's Detroit Tigers, first played football as a member of a team at a former Catholic high school in the neighborhood.

The neighborhood encompasses  with boundaries that are major traffic arteries and commercial zones: Dr. Martin Luther King Jr. Street North on the east; and 16th Street North on the west, 22nd Avenue North on the north side, and 9th Avenue North forming the southern boundary. Downtown St. Petersburg, the Central Avenue Business District and Baywalk are all  away. Both St. Anthony's Hospital and Edward White Memorial Hospital are less than a mile away, as is access to Interstate-275.

The neighborhood contains diverse styles of homes and varying lot sizes but no city-owned parks, although there are several nearby, including Booker Creek Park, Sprague Park, Huggins-Stengel Field and Stewart Field, Woodlawn Park, Crescent Lake Park, Round Lake Park, Mirror Lake Park, Blanc Park, and Euclid Lake Park. In the western section there are more modest homes of a more uniform style. The northeastern section has the most duplex, triplex and small apartment buildings. Many homes have garage apartments accessible from alleys, and nearly every home has access to an alley.

History

The Euclid St. Paul's Neighborhood began as an orange grove in 1912 in a part of town most residents regarded as "out in the country." Co-owned by Mary Eaton, the founder of the St. Petersburg Memorial Historical Society, the  grove was bounded by MLK (then known as Euclid Blvd.) and 12th Streets and 14th and 15th Avenues.

A few homes were constructed in the neighborhood prior to the land boom. One of the oldest homes in the neighborhood, located at 12th Street and 10th Avenue, was built in 1917 as a grand mansion but was used in later years as a sanitarium. Another old home in the neighborhood, located on 19th Avenue and 11th Street, served as a bunkhouse for Eaton's orange pickers.

John B. Green, a developer, purchased the land in 1921 and began developing it into an exclusive neighborhood of various architectural styles. The first subdivisions were Edina-Garden of Eden, Hilcrest, and Old Kentucky. Minimum dollar values and square-foot restrictions were placed on the homes constructed. The homeowner's association at the time designated that homes along 15th Avenue were to be worth at least $6,000 (a hefty price tag for the 1920s) and contain a minimum of 6 rooms exclusive of bathrooms, closets and porches.

During St. Petersburg's land boom of the 1920s, Euclid Place, as it was originally called, continued to grow. The neighborhood spread on the east from 9th Street North (formerly Euclid Boulevard) west to 16th Street North, and from 13th and 14th Avenues northward to 22nd Avenue. As development continued, smaller houses were built.

Local institutions

In 1925, Euclid School was opened in the neighborhood. The grammar school taught several generations of neighborhood children and today serves as administrative offices for Pinellas County Schools. Euclid Methodist Episcopal Church was built in 1936 adjacent to Euclid School on 10th Avenue.

In 1929, St. Paul's Catholic School opened its doors to students, and a Roman Catholic Mass was held regularly in the school gymnasium until the church was built in 1939. The school was originally co-educational, but the last class with boys graduated in 1956. In the 1950s, sometimes 3,000 fans showed up for Friday night Blue Eagles football games in the neighborhood. Bill Freehan, who was a freshman on the football team the final year that boys were at the high school, went on to become an all-star catcher for Major League Baseball's Detroit Tigers. After the 1955-56 school year, the school became a girls-only high school as boys went to the new Bishop Barry Catholic school on Ninth Avenue North. In 1969, St. Paul's closed as a high school when the girls departed for Notre Dame Academy. The school continues to teach children from Kindergarten through eighth grade. St. Paul's Catholic Church celebrated its 75th Jubilee in 2004.

The Euclid St. Paul's Neighborhood Association hosts several social functions throughout the year. Association meetings are held monthly at St. Paul's Catholic School on the first Thursday of the month. The association is also active in fundraising, crime watch and the City Team. In 2005, the city Neighborhood Partnership program awarded the association $3,375 to plant 29 trees (crape myrtle, magnolia, oak, maple) along rights of way.

Starting in 2005, neighborhood volunteers have organized a "ghost tour" of Euclid St. Paul in which guides lead people to various homes where fictional spooky stories are told by costumed hosts. The tour is meant to be low-tech, old-fashioned, family-friendly event.

References

External links
 Euclid-St. Paul's Neighborhood Association

Neighborhoods in St. Petersburg, Florida


Annals of Rome is a turn-based strategy video game developed and published by Personal Software Services. It was first released in the United Kingdom for the ZX Spectrum, Amstrad CPC and Atari ST in 1986. It was then released in Germany for the Commodore 64 and Amiga in 1987 and 1988, respectively. The game is set in the Late Roman Empire, with the objective being to survive for as long as possible against rebelling European states.

Gameplay

The game is played in two windows. The first is the troops movement window, which allows the player to control the placement of troops in the Roman state or to attack computer players. This window shows the number of forces for all players, inflation, popularity and national score of the Roman state, and human player score. The last step for the player in this window is to set the tax rate, between 1.0 and 2.0% (higher taxes cause higher inflation). In the next window, the player decides which of the 21 Senate members will receive command of the various Roman armies. To help the player in making this decision, all Senate members are listed with numbers, the first two indicating their military ability and loyalty, respectively. The last number indicates their age. If the government's popularity falls below 2 (popularity is measured within a range between -5 and +5), armies with disloyal commanders can revolt and try to take Rome. If this happens before 50 BC, the successful rebel will be declared dictator, and if this happens after, he will become emperor, which will lead to a dynasty.

Reception

Despite poor graphics and interface even for 1986, Annals of Rome received an 85% rating from Crash magazine in 1987. In November 1986, Popular Computing Weekly called the game a "perfect choice if you take your strategy games seriously". Because of such popularity, the game received conversion to all computer platforms in its day. Originally, Personal Software Services released the game for C-64, Spectrum, Amstrad CPC and Atari ST (platforms until September 1987) followed by versions for PC and Amiga. Today, the game has been considered a forgotten classic.

Computer Gaming World gave the game a positive review, noting innovative mechanics such as the variable turn length. The review noted that the game felt unfinished and unpolished, citing the lack of victory conditions and poor save mechanism. In 1990 the magazine gave the game three-plus out of five stars, stating that despite the poor graphics and seemingly incomplete nature, "it succeeds on many levels", especially the superior 16-bit versions. In 1993 the magazine gave the game two-plus stars. Orson Scott Card wrote in Compute! that Annals of Romes programmers did an excellent job of recreating Roman history, but that sales would suffer because it "looks like it was programmed in the Bronze Age".

References

1986 video games
Amiga games
Amstrad CPC games
Atari ST games
Commodore 64 games
DOS games
Turn-based strategy video games
War video games set in Europe
ZX Spectrum games
Video games set in the Roman Empire
Video games set in antiquity
Personal Software Services games
Video games developed in the United Kingdom
Single-player video games


"Fox on the Run" is a 1975 song by the British glam rock band Sweet, first recorded in 1974. It was the first Sweet single written by the band, rather than producers Nicky Chinn and Mike Chapman, and was their 14th single overall. The song became the best charting single in Australia in 1975, with six weeks at number one.

Two versions were recorded by Sweet. The original version was produced by Mike Chapman in association with Nicky Chinn on the European version of the 1974 album Desolation Boulevard. Sweet also recorded and produced a more pop-oriented version as a 7" single in 1975, which is the more familiar version of the song. The 1975 single version was included on the Capitol Records version of Desolation Boulevard.

The song's inclusion in the trailer for Guardians of the Galaxy Vol. 2 led to the song reaching number one on the iTunes Rock Chart in late 2016.

Background
"Fox" being slang for an attractive woman, the lyrics are apparently about one of the band's groupies; Bomp! called the song "a definitive hard-rock bubblegum record" and "one of the last glitter classics".

Chart performance

Weekly charts

Year-end charts

Certifications

Personnel
 Brian Connolly – lead vocals
 Steve Priest – bass, lead vocal, backing vocals
 Andy Scott – guitars, synthesizer, backing vocals
 Mick Tucker – drums, percussion, backing vocals

Scorpions version

"Fuchs geh' voran" is a German cover version of the song with lyrics about a fox being chased by hunters to sell its fur. It was released as a single in 1975 by the German rock band Scorpions as The Hunters. The B-side also features a German cover version of another Sweet song, "Action", as "Wenn es richtig losgeht".

Other covers

Many artists and groups have covered this song, including:
The Regrettes (for the AV Undercover series)
Eric Singer
Girlschool
Red Hot Chili Peppers
You Am I
Mad Max
Deadsy
Frankenstein Drag Queens from Planet 13
Ace Frehley
Make-Up
The Academy Is...
Sweet Savage
Nip Drivers for the Desperate Teenage Lovedolls soundtrack.
A 1986 recording by The Replacements is featured on the 2017 live album For Sale: Live at Maxwell's 1986.

Popular culture
The song appears in numerous films, including: Dazed and Confused, Detroit Rock City,  When in Rome, Catch .44, Lords of Dogtown, The Goods: Live Hard, Sell Hard, and The Black Phone.
The song was used in the trailer for Guardians of the Galaxy Vol. 2.
The song was used in the opening credits of the Australian film Kath & Kimderella starring Gina Riley and Jane Turner. It was also used in the series "Kath and Kim" in the season 3, episode 7 titled "Foxy on the Run".
The song was used in the 2023 Peacock Television series Poker Face season 1 episode 2 titled "The Night Shift".
The song was used in the 2017 Netflix series Mindhunter season 1 episode 5.

See also
List of number-one singles in Australia during the 1970s
List of number-one hits of 1975 (Germany)

References

External links

The Sweet songs
1974 songs
1975 singles
1976 singles
Number-one singles in Australia
Number-one singles in Germany
Number-one singles in South Africa
Songs written by Andy Scott (guitarist)
Songs written by Brian Connolly
Songs written by Steve Priest
Songs written by Mick Tucker
Song recordings produced by Mike Chapman
British power pop songs


Alternative Nation was a television show in the U.S. dedicated to alternative music. It aired on MTV from 1992 to 1997, mostly on weeknights. It was hosted by Kennedy.

History
Alternative Nation began airing in 1992. It was a somewhat more mainstream version of sister-show 120 Minutes. While the latter aired videos by more diverse artists, such as Pixies, The Cure, The Jesus and Mary Chain, Bronski Beat, New Order, The Replacements, Robyn Hitchcock, Meat Puppets, Butthole Surfers, and The Verve, Alternative Nation focused primarily on the alternative hits of the day, including videos by Smashing Pumpkins, Nirvana, Stone Temple Pilots, Soundgarden, Alice in Chains, Pearl Jam, Hole, Blind Melon, Weezer, Bush, and Oasis, among others.

MTV Adria (South-Eastern Europe) was the last of the MTV channels to schedule the show, where it was scheduled until September 17, 2017 before getting revived on MTV Germany in January 2023.

List of Hosts
Kennedy (1992–97)

See also

Superock

References

External links

1992 American television series debuts
1997 American television series endings
1990s American music television series
MTV original programming
Alternative rock mass media


StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins.

Function and structure
STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases.  It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly.

The protein consists of an N-terminal sterile alpha motif (SAM) domain, a serine-rich domain, a RhoGAP domain and at the C-terminus, a StAR-related lipid-transfer domain (START).

Tissue distribution and pathology
The protein was identified in part through its differential expression in cancers.  A low level of STARD13 was observed in less differentiated hepatocellular carcinoma tissue with higher RhoA expression.  A small patient study finds that the absence of STARD13 in hepatocellular carcinomas correlates with higher levels of RhoA and a poorer prognosis than patients with carcinomas that were STARD13-positive.

Model organisms

Model organisms have been used in the study of STARD13 function. A conditional knockout mouse line, called Stard13tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and two significant abnormalities were observed. Female homozygous mutants had an increased susceptibility to Citrobacter infection and displayed a decreased hematocrit and hemoglobin content.

Another study of mice lacking STARD13, found it may promote blood vessel formation (angiogenesis), especially by tumor cells.  The promotion of angiogenesis with the loss of STARD13 occurs through the actions of RhoA.

References

Further reading

Genes on human chromosome 13
Genes mutated in mice


AKL may refer to:
 Alpha Kappa Lambda, US collegiate fraternity
Auckland Airport, New Zealand (IATA code AKL)
 Air Kiribati's ICAO code
 Small cargo ships per list of auxiliaries of the United States Navy
 Dry cargo support ships in the list of active Indonesian Navy ships


Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene.

References

Further reading


The Eastbourne Gazette, commonly known as just The Gazette, is a weekly tabloid newspaper, printed on Wednesdays and published since 1859 in Eastbourne, England.

History
The Gazette was the town's first newspaper. Nowadays, the paper is edited and created by Beckett Newspapers, based in Eastbourne, and printed by Johnston Press at their headquarters in Hilsea, Portsmouth. Aleister Crowley once edited a chess column for the paper. The Gazette was the newspaper that the fictional Private Cheeseman from Dad's Army was a correspondent for.

Sister newspaper
The Gazette also has a sister newspaper, owned by Beckett Newspapers, called the Eastbourne Herald. The Herald is printed on a Friday and is more expensive than the Gazette. Eastbourne is one of the few remaining towns in the UK which has a midweek paid-for newspaper as well as an end-of-week title.

References

External links
 Eastbourne Gazette website

Newspapers published in Sussex
Eastbourne
Newspapers established in 1859
1859 establishments in England


Brother of CDO is a protein that in humans is encoded by the BOC gene.

CDON (MIM 608707) and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM]

Interactions
BOC (gene) has been shown to interact with CDON.

References

External links

Further reading


NACHT, LRR and PYD domains-containing protein 12 is a protein that in humans is encoded by the NLRP12 gene.

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]

References

Further reading

LRR proteins
NOD-like receptors


Myeloid-associated differentiation marker is a protein that in humans is encoded by the MYADM gene.

References

Further reading


Unreal Estate is the second live album by Swedish death metal band Entombed. Originally it was planned to be released on 20 October 2004, but printing problems pushed its release to February 2005.

Track listing

References

Entombed (band) albums
2004 live albums