The troubled history of Spanish–American relations has been seen as one of "love and hate". The groundwork was laid by the colonization of parts of the Americas by Spain before 1700. The Spaniards were the first Europeans to establish a permanent settlement in what is now United States territory. The first settlement in modern-day United States territory was San Juan, Puerto Rico, founded in 1521 by Spanish explorer Juan Ponce de León. 35 years later, Spanish admiral Pedro Menéndez de Avilés founded the city of St. Augustine, Spanish Florida (the earliest settlement in the continental United States), which became a small outpost that never grew very large. More permanent, much larger colonies were established in New Mexico and California, with a few in Texas and Arizona, forming part of the colonial history of the United States. Although the Spanish elements in the history of the United States were mostly ignored by American historians in the decades after independence, the concept of the "Spanish borderlands" in the American Southwest was developed by American historians in the 20th century, which integrated Spain into U.S. history.

Spain provided indirect support to the new United States by fighting against Great Britain during the American Revolutionary War. Madrid tacitly recognised the independence of the United States in 1783. The purchase of the underdeveloped Spanish Florida by the US was made effective in 1821. The U.S. gave diplomatic support to the breakaway Spanish colonies as they secured their independence around 1820. American diplomatic offers to buy Cuba in the 1850s failed. When Cuba revolted in the late 19th century American opinion became strongly hostile to Spanish brutality. The Spanish–American War erupted in 1898. The Spanish defeat in the conflict entailed the loss of the last Spanish colonies outside north Africa, notably Cuba, Puerto Rico, Guam and the Philippines.

When the Spanish Civil War erupted in 1936, Washington was neutral and banned arms sales to either side; oil sales were allowed. Congress endorsed the embargo by a near-unanimous vote. President Franklin Roosevelt quietly favored the left-wing Republican (or "Loyalist") government, but intense pressure by American Catholics forced him to maintain a policy of neutrality. Spain was carefully neutral in World War II, despite its ties with Nazi Germany.

As the Cold War deepened after 1950, Washington threw a lifeline to the Francoist dictatorship that included financial aid and military bases. Membership in NATO came in 1982, after Francisco Franco's death and the Spanish transition to democracy.

Spain and the American Revolution

Spain declared war on Great Britain as an ally of the Kingdom of France, and provided supplies and munitions to the Continental Army.  However Spain was not an ally of the Patriots. It was reluctant to recognize the independence of the United States, because it distrusted revolutionaries. Historian Thomas A. Bailey says of Spain:
Although she was attracted by the prospect of a war [against England] for restitution and revenge, she was repelled by the specter of an independent and powerful American republic. Such a new state might reach over the Alleghenies into the Mississippi Valley and grasp territory that Spain wanted for herself.

Among the most notable Spaniards warriors was Bernardo de Gálvez y Madrid, Count of Gálvez, who defeated the British at Manchac, Baton Rouge, and Natchez in 1779, freeing the lower Mississippi Valley of British forces and relieved the threat to the capital of Spanish Louisiana, New Orleans. In 1780, he recaptured Mobile and in 1781 took by land and by sea Pensacola, leaving the British with no bases in the Gulf of Mexico. In recognition for his actions to the American cause, George Washington took him to his right in the parade of July 4 and the American Confederation Congress cited Gálvez for his aid during the Revolution.

Floridablanca instructed the Count of Aranda to sign a Treaty with the United States on March 17, 1783, thus making Spain tacitly recognise then the independence of the US.

Another notable contributor was Diego de Gardoqui, who was appointed as Spain's first minister to the United States of America in 1784. Gardoqui became well acquainted with Washington, and also marched in President Washington's inaugural parade. King Charles III of Spain continued communications with Washington, sending him gifts such as blooded livestock from Spain that Washington had requested for his farm at Mount Vernon.

Spain and the United States in the late 18th century

The United States' first ambassador to Spain was John Jay (but was not formally received at court). Jay's successor, William Carmichael, married a Spanish woman and is buried in the Catholic cemetery in Madrid. Some friendly ties were established: George Washington had established the American mule-raising industry with high-quality large donkeys sent to him by the King of Spain (as well as Lafayette).

Spain fought the British as an ally of France during the Revolutionary War, but it distrusted republicanism and was not officially an ally of the United States. After the war, the main relationships dealt with trade, with access to the Mississippi River, and with Spanish maneuvers with Native Americans to block American expansion. Spain controlled the territories of Florida and Louisiana, positioned to the south and west of the United States. Americans had long recognized the importance of navigation rights on the Mississippi River, as it was the only realistic outlet for many settlers in the trans-Appalachian lands to ship their products to other markets, including the Eastern Seaboard of the United States. Despite having fought a common enemy in the Revolutionary War, Spain saw U.S. expansionism as a threat to its empire. Seeking to stop the American settlement of the Old Southwest, Spain denied the U.S. navigation rights on the Mississippi River, provided arms to Native Americans, and recruited friendly American settlers to the sparsely populated territories of Florida and Louisiana. Additionally, Spain disputed the Southern and Western borders of the United States. The most important border dispute centered on the border between Georgia and West Florida, as Spain and the United States both claimed parts of present-day Alabama and Mississippi. Spain paid cash to American General James Wilkinson for a plot to make much of the region secede, but nothing came of it.  Meanwhile, Spain worked on the goal of stopping American expansion by setting up an Indian buffer state in the South. They worked with Alexander McGillivray (1750–1793), who was born to a Scottish trader and his French-Indian wife, and he had become a leader of the Creek tribe as well as an agent for British merchants. In 1784–1785, treaties were signed with Creeks, the Chickasaws, and the Choctaws to make peace among themselves, and ally with Spain. While the Indian leaders were receptive, Yankee merchants were much better suppliers of necessities than Spain, and the pan-Indian coalition proved unstable.

On the positive side, Spanish merchants welcomed trade with the new nation, which had been impossible when it was a British colony. it therefore encourage the United States to set up consulates in Spain's New World colonies American merchants and Eastern cities likewise wanted to open trade with the Spanish colonies which had been forbidden before 1775. A new line of commerce involved American merchants importing goods from Britain, and then reselling them to the Spanish colonies.

John Jay negotiated a treaty with Spain to resolve these disputes and expand commerce. Spain also tried direct diplomacy offering access to the Spanish market, but the cost of closing the Mississippi to Western farmers for 25 years and blocking southern expansionists. The resulting Jay–Gardoqui Treaty was rejected by coalition of Southerners led by James Madison and James Monroe of Virginia, who complained that it hurt their people and instead favored Northeastern commercial interests. the treaty was defeated.

Pinckney's Treaty, also known as the Treaty of San Lorenzo or the Treaty of Madrid, was signed in San Lorenzo de El Escorial on October 27, 1795, and established intentions of friendship between the United States and Spain. It also defined the boundaries of the United States with the Spanish colonies and guaranteed the United States navigation rights on the Mississippi River. Both sides remained distrustful. Secretary of State Timothy Pickering feared that Spain might turn over Louisiana to her much more powerful associate France. Spain, by early 1797, was stalling the fulfillment of the 1795 treaty. Finally in 1798 Madrid backed down and relations improved.

The early nineteenth century
Spanish–American relations suffered during the 19th century, as both countries competed for territory and concessions in the New World. "Culturally, they misunderstood and distrusted each other", James W. Cortada has written. "Political conflicts and cultural differences colored relations between the two nations throughout the nineteenth century, creating a tradition of conflict of a generally unfriendly nature. By 1855, a heritage of problems, hostile images, and suspicions existed which profoundly influenced their relations."

During the Peninsular War, when Spain had two rival Kings – the overthrown Bourbon Fernando VII and Napoleon's brother, Joseph Bonaparte, enthroned as José I of Spain – the United States officially maintained a neutral position between them. Ambassador Luis de Onís who arrived in New York in 1809, representing Fernando VII's government, was refused an audience to present his credentials to President James Madison. He was only recognized officially by the US government in 1815, following Napoleon's defeat – though in the meantime he had established himself in Philadelphia and unofficially conducted extensive diplomatic activity.

The two countries found themselves on opposite sides during the War of 1812. By 1812 the continued existence of Spanish colonies east of the Mississippi River caused resentment in the United States. Escaped slaves went there and armed themselves. Spain stopped returning escapees in 1794. With clandestine support from Washington, American settlers in the Floridas revolted against Spanish rule and Spain lost West Florida. Between 1806 and 1821, the area known as the "Sabine Free State" was an area between Spanish Texas and the U.S. Louisiana Territory that both sides agreed to maintain as neutral due to disputes over the area.

The Adams–Onís Treaty between the two countries was signed in 1819. The treaty was the result of increasing tensions between the U.S. and Spain regarding territorial rights at a time of weakened Spanish power in the New World. In addition to granting Florida to the United States, the treaty settled a boundary dispute along the Sabine River in Texas and firmly established the boundary of U.S. territory and claims through the Rocky Mountains and west to the Pacific Ocean in exchange for the U.S. paying residents' claims against the Spanish government up to a total of $5,000,000 and relinquishing its own claims on parts of Texas west of the Sabine River and other Spanish areas.

By the mid-1820s, Spaniards believed that the United States wanted to control the entire New World at Spain's expense, considering the independence movements in Latin America as proof of this. In 1821, a Spaniard wrote that Americans "consider themselves superior to all the nations of Europe." In the United States, Spain was viewed as permanently condemned by the Black Legend, and as a backward, crude, and despotic country that opposed the Monroe Doctrine and Manifest destiny. Nevertheless, travel literature on Spain sold well in the US, and the writings of Washington Irving, who had served as U.S. Minister to Spain, generated some friendly spirit in the United States towards Spain.

Mid-nineteenth century
Tensions continued throughout the 19th century. Queen Isabella II, who reigned from 1833 to 1868, became a dominant figure in Spanish-American relations. In 1839 she became involved in the Amistad affair, over the fate of the schooner La Amistad and the 53 slaves she carried. Isabella was one of several claimants to their ownership, and even after its resolution in 1841, following a U.S. Supreme Court decision, the Spanish government continued to press for compensation. She involved her country in the Chincha Islands War (1864–1866), which pitted Spain against her former possessions of Peru and Chile. The American Minister to Chile, Hugh Judson Kilpatrick, was involved in an attempt to arbitrate between the combatants of the Chincha Islands War. The attempt failed, and Kilpatrick asked the American naval commander Commander Rodgers to defend the port and attack the Spanish fleet. Admiral Casto Méndez Núñez famously responded with, "I will be forced to sink [the US ships], because even if I have one ship left I will proceed with the bombardment. Spain, the Queen and I prefer honor without ships than ships without honor." ("España prefiere honra sin barcos a barcos sin honra".) During the Chincha Islands War, Spanish Admiral Pareja imposed a blockade of Chile's main ports. The blockade of the port of Valparaíso, however, caused such great economic damage to Chilean and foreign interests, that the British and American governments lodged a formal protest.

During the mid-nineteenth century, one American diplomat declared:

The romantic historian Washington Irving (1783–1859) was appointed minister by President John Tyler in 1842–1846. The history, customs, and pageantry of Spain seduced Irving. He admired the de facto head of state, regent Baldomero Espartero, then locked in a power struggle with the Spanish Cortes. Irving's official reports on the ensuing civil war and revolution expressed his romantic fascination with the regent as young Queen Isabella's knight protector, He wrote with an anti-republican, undiplomatic bias. Though Espartero, ousted in July 1843, remained a fallen hero in his eyes, Irving began to view Spanish affairs more realistically.

Cuba
But it was the issue of Cuba that dominated relations between Spain and the United States during this period. At the same time that the United States wished to expand its trade and investments in Cuba during this period, Spanish officials enforced a series of commercial regulations designed to discourage trade relations between Cuba and the U.S. Spain believed that American economic encroachment would result in physical annexation of the island; the kingdom fashioned its colonial policies accordingly.

In a letter to Hugh Nelson, U.S. Minister to Spain, Secretary of State John Quincy Adams described the likelihood of U.S. "annexation of Cuba" within half a century despite obstacles: "But there are laws of political as well as of physical gravitation; and if an apple severed by the tempest from its native tree cannot choose but fall to the ground, Cuba, forcibly disjoined from its own unnatural connection with Spain, and incapable of self support, can gravitate only towards the North American Union, which by the same law of nature cannot cast her off from its bosom."

In 1850, John A. Quitman, Governor of Mississippi, was approached by the filibuster Narciso López to lead his filibuster expedition of 1850 to Cuba. Quitman turned down the offer because of his desire to serve out his term as governor, but did offer assistance to López in obtaining men and material for the expedition.

In 1854 a secret proposal known as the Ostend Manifesto was devised by American diplomats to purchase Cuba from Spain for $130 million, thereby opening new slave territory. The manifesto was rejected due to vehement objections from abolitionist activists when the plans became public. When President James Buchanan addressed Congress on December 6, 1858, he listed several complaints against Spain, which included the treatment of Americans in Cuba, lack of direct diplomatic communication with the captain general of Cuba, maritime incidents, and commercial barriers to the Cuban market. "The truth is that Cuba", Buchanan stated, "in its existing colonial condition, is a constant source of injury and annoyance to the American people." Buchanan went on to hint that the US may be forced to purchase Cuba and stated that Cuba's value to Spain "is comparatively unimportant." The speech shocked Spanish officials.

Santo Domingo
Another source of conflict and rivalry was the Captaincy General of Santo Domingo, recreated when Spain annexed the independent Dominican Republic at the request of President Pedro Santana in 1861. The U.S. and Spain had competed with one another for influence in Hispaniola in the 1850s and 1860s; the U.S. was worried about a possible military expansion by Spain in the Caribbean and the Gulf of Mexico (which would make it harder to acquire Cuba).

Spain and the American Civil War and after

At the outbreak of the American Civil War, the Union was concerned about possible European aid to the Confederacy as well as official diplomatic recognition of the breakaway republic. In response to possible intervention from Spain, President Abraham Lincoln sent Carl Schurz, who he felt was able and energetic, as minister to Spain. Schurz's chief duty was to block Spanish recognition of, and aid to, the Confederacy. Part of the Union strategy in Spain was to remind the Spanish court that it had been Southerners, now Confederates, who had pressed for annexation of Cuba. Schurz was successful in his efforts; Spain officially declared neutrality on June 17, 1861. However, since neither the Union nor the Confederacy would sign a formal treaty guaranteeing that Cuba would never be threatened, Madrid remained convinced that American imperialism would resume as soon as the Civil War had ended.

Horatio Perry was Secretary of the U.S. Legation in Madrid. His Spanish wife, Carolina Coronado (1820–1911), one of the most well-known poets writing in mid-19th-century Spain, played a role. She both negotiated with the Spanish royal family in private and, through a series of widely published poems, promoted the aims of the Lincoln administration, especially abolition. At a time when women were not invited to public political conversations, Coronado succeeded in persuasively arguing against Spain's imperial legacy and urging support to rectify her nation's past colonial blunders, especially the introduction of slavery to the Americas.

A major revolt broke out in Cuba, the Ten Years' War (1868–1878). President Ulysses S. Grant took a keen interest; he clearly favored independence from Spain. He proposed American meditation, but Spain refused and the revolt slowly petered out. Grant's Secretary of State Hamilton Fish  had a more balanced approach. Fish also resolved the Virginius Affair of 1873–1875.

Spanish–American War

The Spanish–American War began in April 1898. Hostilities halted in August of that year, and the Treaty of Paris was signed in December.

American diplomats were responsive to the business community's demands for overseas expansion. Minister Hannis Taylor (1893–97) tried to support American business regarding Cuba. He was largely ignored, and he blamed Madrid's ineptitude. In June 1897, President William McKinley appointed Stewart L. Woodford to the post of Envoy Extraordinary and Minister Plenipotentiary to Spain, in a last attempt to convince the Spanish government to sell its colonies. Spain refused and severed diplomatic relations with the U.S. on April 21, 1898.

The War was the first conflict in which military action was precipitated by media involvement. The war grew out of U.S. interest in a fight for revolution between the Spanish military and citizens of their Cuban colony. American yellow press fanned the flames of interest in the war by fabricating atrocities during the Cuban War of Independence, to justify intervention in a number of Spanish colonies worldwide, like Puerto Rico, the Philippines, Guam and the Caroline Islands.

Many stories were either elaborated, misrepresented or completely fabricated by journalists to enhance their dramatic effect. Theodore Roosevelt, who was the Assistant Secretary of the Navy at this time, wanted to use the conflict both to help heal the wounds still fresh from the American Civil War, and to increase the strength of the US Navy, while simultaneously establishing America as a presence on the world stage. Roosevelt put pressure on the United States Congress to come to the aid of the Cuban people. He emphasized Cuban weakness and femininity to justify America's military intervention.

Riots in Havana by pro-Spanish "Voluntarios" gave the United States the perfect excuse to send in the warship . After the unexplained explosion of the Maine, tension among the American people was raised by the anti-Spanish campaign that accused Spain of extensive atrocities, agitating American public opinion.

The war ended after decisive naval victories for the United States in the Philippines and Cuba, only 109 days after the outbreak of war. The Treaty of Paris, which ended the conflict, gave the United States ownership of the former Spanish colonies of Puerto Rico, the Philippines and Guam.

Spain had appealed to the common heritage shared by her and the Cubans. On March 5, 1898, Ramón Blanco y Erenas, Spanish governor of Cuba, proposed to Máximo Gómez that the Cuban generalissimo and troops join him and the Spanish army in repelling the United States in the face of the Spanish–American War. Blanco appealed to the shared heritage of the Cubans and Spanish, and promised the island autonomy if the Cubans would help fight the Americans. Blanco had declared: "As Spaniards and Cubans we find ourselves opposed to foreigners of a different race, who are of a grasping nature. ... The supreme moment has come in which we should forget past differences and, with Spaniards and Cubans united for the sake of their own defense, repel the invader. Spain will not forget the noble help of its Cuban sons, and once the foreign enemy is expelled from the island, she will, like an affectionate mother, embrace in her arms a new daughter amongst the nations of the New World, who speaks the same language, practices the same faith, and feels the same noble Spanish blood run through her veins." Gómez refused to adhere to Blanco's plan.

In Spain, a new cultural wave called the Generation of '98 responded to the deep trauma caused by this disastrous war, marking a renaissance of culture in Spain.

Spanish–American relations: 1898–1936
In spite of having been proven false, many of the lies and negative connotations against Spain and the Spanish people, product of the American propaganda of the Spanish–American War, lingered for a long time after the end of the war itself, and contributed largely to a new recreation of the myth of the Black Legend against Spain.

The war also left a residue of anti-American sentiment in Spain, whose citizens felt a sense of betrayal by the very country they had helped to obtain their independence. Many historians and journalists pointed out also the needless nature of this war, because up to that time, relations between Spain and the United States had always enjoyed very amiable conditions, with both countries resolving their differences with mutual agreements that benefited both sides, such as with the sale of Florida by terms of the Treaty of Amity.

Nonetheless, in the post-war period, Spain enhanced its trading position by developing closer commercial ties with the United States. The two countries signed a series of trade agreements in 1902, 1906, and 1910. These trade agreements led to an increased exchange of manufactured goods and agricultural products. American tourists began to come to Spain during this time.

Spain, under Alfonso XIII, remained neutral during the First World War, and the war greatly benefited Spanish industry and exports. At the same time, Spain did intern a small German force in Spanish Guinea in November 1915 and also worked to ease the suffering of prisoners of war. Spain was a founding member of the League of Nations in 1920 (but withdrew in May 1939).

The two countries were engaged in a tariff war after the Fordney–McCumber Tariff was passed in 1922 by the United States; Spain raised tariffs on American goods by 40%. In 1921, a "Student on tariffs" had warned against the Fordney Bill, declaring in The New York Times that "it should be remembered that the Spanish are a conservative people. They are wedded to their ways and much inertia must be overcome before they will adopt machinery and devices such as are largely exported from the United States. If the price of modern machinery, not manufactured in Spain, is increased exorbitantly by high customs duties, the tendency of the Spanish will be simply to do without it, and it must not be imagined that they will purchase it anyhow because it has to be had from somewhere."

In 1928, Calvin Coolidge greeted King Alfonso on the telephone; it was the first use by the president of a new transatlantic telephone line with Spain.

Culturally, during the 1920s, Spanish feelings towards the United States remained ambivalent. A New York Times article dated June 3, 1921, called "How Spain Views U.S.", quotes a Spanish newspaper (El Sol) as declaring that the "United States is a young, formidable and healthy nation." The article in El Sol also expressed the opinion that "the United States is a nation of realities, declaring that Spain in its foreign policy does not possess that quality." The Spanish newspaper, in discussing the relations between Spain and the U.S., also argued "that the problem of acquiring a predominant position in the South American republics should be vigorously studied by Spain."

In 1921, Luis Araquistáin had written a book called El Peligro Yanqui ("The Yankee Peril"), in which he condemned American nationalism, mechanization, anti-socialism ("socialism is a social heresy there") and architecture, finding particular fault with the country's skyscrapers, which he felt diminished individuality and increased anonymity. He called the United States "a colossal child: all appetite..." Nevertheless, America exercised an obvious fascination on Spanish writers during the 1920s. While in the United States, Federico García Lorca had stayed, among other places, in New York City, where he studied briefly at Columbia University School of General Studies. His collection of poems Poeta en Nueva York explores his alienation and isolation through some graphically experimental poetic techniques. Coney Island horrified and fascinated Lorca at the same time. "The disgust and anatagonism it aroused in him", writes C. Brian Morris, "suffuse two lines which he expunged from his first draft of 'Oda a Walt Whitman': "Brooklyn filled with daggers / and Coney Island with phalli."

The Spanish Civil War 1936–1939
President Franklin D. Roosevelt named his favorite historian Claude Bowers (1878–1958) as ambassador to Spain, 1933–39. Bowers prophesied that Washington's unwillingness to take action during the Spanish Civil War would make wider war inevitable. His influence was minimal in Washington.

When the Spanish Civil War erupted in 1936, the United States remained neutral and banned arms sales to either side. This was in line with both American neutrality policies, and with a Europe-wide agreement to not sell arms for use in the Spanish war lest it escalate into a world war. Congress endorsed the embargo by a near-unanimous vote. Only armaments were embargoed; American companies could sell oil and supplies to both sides. Roosevelt quietly favored the left-wing Republican (or "Loyalist") government, but intense pressure by American Catholics forced him to maintain a policy of neutrality. The Catholics insisted that lifting the embargo in favor of the Republican government "could only be the act of a hypocrite or a sucker" because, according to them, priests and nuns weren't given proper burials and were immolated by the anarchist elements of the Loyalist coalition. This successful pressure on Roosevelt was one of the handful of foreign policy successes notched by Catholic pressures on the White House in the 20th century.
Nazi Germany and Fascist Italy provided munitions, and air support, and troops to the Nationalists, led by Francisco Franco. The Soviet Union provided aid to the Loyalist government, and mobilized thousands of volunteers to fight, including several hundred Americans in the Abraham Lincoln Battalion. All along the Spanish military forces supported the nationalists, and they steadily pushed the government forces back. By 1938, however, Roosevelt was planning to secretly send American warplanes through France to the desperate Loyalists. His senior diplomats warned that this would worsen the European crisis, so Roosevelt desisted.

The Nationalists, led by Francisco Franco, received important support from some elements of American business. The American-owned Vacuum Oil Company in Tangier, for example, refused to sell to Republican ships and at the outbreak of the war, the Texas Oil Company rerouted oil tankers headed for the Republic to the Nationalist-controlled port of Tenerife, and supplied tons of gasoline on credit to Franco until the war's end. American automakers Ford, Studebaker, and General Motors provided a total of 12,000 trucks to the Nationalists. After the war was over, José María Doussinague, who was at the time undersecretary at the Spanish Foreign Ministry, said, "without American petroleum and American trucks, and American credit, we could never have won the Civil War."

The Communist Party USA energetically recruited soldiers to fight against Franco in the Lincoln Battalion. In addition American anarchists sent the Sacco and Vanzetti Century of the Durruti Column. American poets like Alvah Bessie, William Lindsay Gresham, James Neugass, and Edwin Rolfe were members of the International Brigades. Wallace Stevens, Langston Hughes, Edna St. Vincent Millay, Randall Jarrell, and Philip Levine also wrote poetic responses to the Spanish Civil War. Kenneth Porter's poetry speaks of America's "insulation by ocean and 2,000 miles of complacency", and describes the American "men from the wheatfields / Spain was a furious sun which drew them along paths of light."

World War II

Francoist Spain sympathized with the Axis powers during World War II. While officially neutral, General Franco's government sold considerable material, especially tungsten, to both sides, including Germany. Thousands volunteered in Blue Division, which fought for the Axis. As Germany weakened, Spain cut back its sales. Ambassador Alexander W. Weddell (1939–1942) managed to resolve a dispute over the National Telephone Company, the American owned (ITT) company that ran Spain's telephone system. He and Foreign Minister Ramón Serrano Suñer deeply disliked each other. Much more successful was historian Carlton J. H. Hayes who served as ambassador from 1942 to 1945.  He was attacked at the time from the left for being overly friendly with Franco, but it has been generally held that he played a vital role in preventing Franco from siding with the Axis powers during the war. Historian Andrew N. Buchanan argues that Hayes made Spain into "Washington's 'silent ally.'"

John P. Willson argues that Hayes organized and expedited relief efforts for Jewish refugees moving through Spain. The U.S. War Refugee Board advocated a more dynamic policy of rescue rather than mere relief. The Board's hopes were frustrated more by Spanish reluctance than by Hayes'. Historian Emmet Kennedy rejects allegations that Hayes was an admirer of Franco. Instead he was "a tough critic of the caudillo's 'fascism'". Hayes played a central role in rescuing 40,000 refugees – French, British, Jews and others from Hitler. He helped them cross the Pyrenees into Spain and onward to North Africa. He made Spain "a haven from Hitler." In retirement, Kennedy finds, Hayes advocated patient diplomacy, rather than ostracism or subversion of Franco's Spain. That was the policy adopted by President Dwight D. Eisenhower as Franco led Spain into an alliance with the U.S. in the 1950s. The American Jewish Joint Distribution Committee operated openly in Barcelona.

Franco and the Cold War

With the end of World War II, Spain suffered from the economic consequences of its isolation from the international community. Spain was blocked from joining the United Nations, primarily by the large Communist element in France.  By contrast the American officials 1946 "praised the favorable 'transformation' that was occurring in US–Spanish relations." United States needed Spain as a strategically located ally in the Cold War against the Soviet Union after 1947. Unlike the case of other European countries (where the US' image was identified with a "liberating" function in World War II and a role as "generous" investors in the Marshall Plan) and not unlike the case of some Latin American countries, the image of the United States in Spain was thus constructed by and large upon the American cooperation with the Francoist dictatorship.

President Harry S. Truman was a very strong opponent of Franco, calling him an evil anti-Protestant dictator comparable to Hitler, Mussolini, and Hirohito. Truman withdrew the American ambassador (but diplomatic relations were not formally broken), kept Spain out of the UN, and rejected any Marshall Aid to Spain. However, as the Cold War escalated, support for Spain sharply increased in the Pentagon, Congress, the business community and other influential elements especially Catholics and cotton growers.  Liberal opposition to Spain faded after the left-wing Henry A. Wallace element broke with the Democratic Party in the 1948 presidential election; the Congress of Industrial Organizations dropped its strong opposition and became passive on the issue.  As Secretary of State Dean Acheson increased his pressure on Truman, the president, stood alone in his administration as his own top appointees wanted to normalize relations.  When China entered the Korean War and pushed American forces back, the argument for allies became irresistible. Admitting that he was "overruled and worn down," Truman relented and sent an ambassador and made loans available in late 1950.

Trade relations improved.  Exports to Spain rose from $43 million in 1946 to $57 million in 1952; imports to the US rose from $48 million to $63 million. A  formal alliance commenced with the signing of the Pact of Madrid in 1953. Spain was then admitted to the United Nations in 1955. American poet James Wright wrote of Eisenhower's visit: "Franco stands in a shining circle of police. / His arms open in welcome. / He promises all dark things will be hunted down."

In the context of the Arab–Israeli conflict, Spain played the role of mediator between the Arab countries (such as the Nasser's United Arab Republic) and the United States. The Spanish diplomacy, led by Fernando María Castiella, showed disregard for what Spain regarded as the unconditional US support to the State of Israel and for the American attempt to sow discord among the Arab nations.

Between 1969 and 1977, the period comprising the mandates of Henry Kissinger as National Security advisor and as Secretary of State of the US during the Nixon and Ford administrations, the US foreign policy towards Spain was driven by the American need to guarantee access to the military bases on Spanish soil. Military facilities of the United States in Spain built during the Franco era include Naval Station Rota and Morón Air Base, and an important facility existed at Torrejón de Ardoz. Torrejón passed under Spanish control in 1988. Rota has been in use since the 1950s. Crucial to Cold War strategy, the base did have nuclear weapons stationed on it for some time, and at its peak size, in the early 1980s, was home to 16,000 sailors and their families. The presence of these bases in Spain was much unpopular among the Spanish people (according to a 1976 poll by Louis Harris International, only 1 out of 10 Spaniards supported the American presence in the country); there were occasional protests against them, including a demonstration during President Ronald Reagan's 1985 visit to Spain.

During the agony of the Franco dictatorship and later Transition, Kissinger, related to the realist school, would support the notion of an orderly regime change for Spain, thus not risking access to the bases as well as facilitating the full incorporation of Spain to the Western sphere, putting nearly all the eggs on the basket of Juan Carlos I.

President Richard Nixon toasted Franco and after Franco's 1975 death, stated: "General Franco was a loyal friend and ally of the United States."

Spanish Transition and shared NATO membership

In 1976, Spain and the United States signed a Treaty of Friendship and Cooperation (Tratado de Amistad y Cooperación), coinciding with the new political system in Spain, which became a constitutional monarchy under Juan Carlos I, with Carlos Arias Navarro as prime minister. Juan Carlos had already established friendly ties with the United States. As prince, he had been a guest of Nixon on January 26, 1971.

There was a brief strain in relations after the 1981 Spanish coup d'état attempt by neo-Francoist elements in the Civil Guard and Spanish Army, which Secretary of State Alexander Haig referred to as an "internal affair." A month after the coup was suppressed Haig visited Madrid to mend relations with the King, Prime Minister Leopoldo Calvo-Sotelo, and Leader of the Opposition Felipe González to prevent it from interfering with Spain's entry into NATO. Haig also unsuccessfully tried to get Spain to oppose the Communist presence in Central America, including the Sandinista government in Nicaragua.

In regard of the military bases, the 1986 referendum on NATO membership and its result provided the Spanish government led by Felipe González with some leverage vis-à-vis the re-negotiation of the bilateral agreements with the US, and thus Spain asserted a larger degree of sovereignty.

In 1987, Juan Carlos I became the first King of Spain to visit the former Spanish possession of Puerto Rico.

An Agreement on Defense Cooperation was signed by the two countries in 1989 (it was revised in 2003), in which Spain authorized the United States to use certain facilities at Spanish Armed Forces installations. On June 7, 1989, an agreement on cultural and educational cooperation was signed.

On 11 January 2001, US secretary of State Madeleine Albright and Spanish foreign minister Josep Piqué signed a joint declaration updating the terms of the bilateral cooperation, and in which the creation of a consultative bilateral defence committee (first met in May 2003) was agreed.

Iraq War

Prime Minister José María Aznar actively supported George W. Bush and UK Prime Minister Tony Blair in the War on Terrorism.Aznar met with Bush in a private meeting before 2003 invasion of Iraq to discuss the situation of in the UN Security Council. The Spanish newspaper El País leaked a partial transcript of the meeting. Aznar actively encouraged and supported the Bush administration's foreign policy and the U.S. invasion of Iraq in 2003, and was one of the signatories of the letter of the eight defending it on the basis of secret intelligence allegedly containing evidence of the Iraqi government's nuclear proliferation. The majority of the Spanish population, including some members of Aznar's Partido Popular, were against the war.

After the 2004 Spanish general election, in which the Spanish Socialist Workers' Party received more votes than expected as a result, besides other issues, of the government's handling of the 2004 Madrid train bombings, José Luis Rodríguez Zapatero succeeded Aznar as Prime Minister. Before being elected, Zapatero had opposed the American policy in regard to Iraq pursued by Aznar. During the electoral campaign Zapatero had promised to withdraw the troops if control in Iraq was not passed to the United Nations after June 30 (the ending date of the initial Spanish military agreement with the multinational coalition that had overthrown Saddam Hussein). On April 19, 2004, Zapatero announced the withdrawal of the 1300 Spanish troops in Iraq.

The decision aroused international support worldwide, though the American Government claimed that the terrorists could perceive it as "a victory obtained due to 11 March 2004 Madrid train bombings". John Kerry, the Democratic candidate for the American Presidency, asked Zapatero not to withdraw the Spanish soldiers. Some months after withdrawing the troops, the Zapatero government agreed to increase the number of Spanish soldiers in the War in Afghanistan and to send troops to Haiti to show the Spanish Government's willingness to spend resources on international missions approved by the UN.

Bush and Zapatero, 2004–2008

The withdrawal caused a four-year downturn in relations between Washington and Madrid. A further rift was caused by the fact that Zapatero openly supported Democratic challenger John Kerry on the eve of the U.S. elections in 2004. Zapatero was not invited to the White House until the last months of the Bush administration, nor was Bush invited to La Moncloa. Aznar had visited Washington several times, becoming the first Spanish prime minister to address a joint meeting of Congress, in February 2004. Bush's fellow Republican, and candidate for the 2008 U.S. presidential election, John McCain, refused to commit to a meeting with Zapatero were he to be elected.

Spain under Zapatero turned its focus to Europe from the United States, pursuing a middle road in dealing with tensions between Western powers and Islamic populations. In a May 2007 interview with El País, Daniel Fried, Assistant Secretary for European and Eurasian Affairs, commenting on the overall relationship between Spain and the United States, stated: "We work together very well on some issues. I think the Spanish–American relationship can develop more. I think some Spanish officials are knowledgeable and very skilled professionals and we work with them very well. I would like to see Spain active in the world, working through NATO, active in Afghanistan. You're doing a lot in the Middle East because Moratinos knows a lot about it. But Spain is a big country and your economy is huge. I think Spain can be a force for security and peace and freedom in the world. I believe that Spain has that potential, and that's how I would like to see Spanish–American relations developing."

Cuba

In 2007, Condoleezza Rice criticized Spain for not doing more to support dissidents in communist Cuba. American officials were irked by the fact that Miguel Ángel Moratinos, Minister of Foreign Affairs, chose not to meet with Cuban dissidents during a visit to the United States in April 2007. "There is no secret that we have had differences with Spain on a number of issues, but we have also had very good cooperation with Spain on a number of issues", Rice remarked. Moratinos defended his decision, believing it better to engage with the Cuban regime than by isolating it. "The U.S. established its embargo", he remarked. "We don't agree with it but we respect it. What we hope is that they respect our policy", Moratinos remarked. "What Spain is not prepared to do is be absent from Cuba. And what the U.S. has to understand is that, given they have no relations with Cuba, they should trust in a faithful, solid ally like Spain."

Venezuela and Bolivia

In addition to policy differences towards Cuba, the United States and Spain have been at variance in their dealings with Venezuela under Hugo Chávez and Bolivia under Evo Morales, both of them socialists. Spain under Zapatero was initially friendly to both regimes. However, Morales’ plan to nationalize the gas sector of Bolivia caused tension with Spain, as Repsol, a Spanish company, has major interests in that South American country. In regards to Venezuela, Zapatero also took issue with Chávez's elected socialist government. Spain's relations with Venezuela were further worsened by the November 10, 2007, incident at the Ibero-American Summit in Santiago, Chile, in which King Juan Carlos told Chávez to "shut up".

Despite its waning support for Chávez, Spain stated in May 2007 that it would pursue a €1.7 billion, or $2.3 billion, contract to sell unarmed aircraft and boats to Venezuela. In 2006, over 200,000 workers were employed by over 600 American firms operating in Spain. They were attracted by that country's low taxes, privatized state-owned companies, and liberalized economy. Furthermore, some 200 Spanish companies operated in the U.S., especially in construction and banking.

New stage in relations: 2009–present
Three days after Barack Obama was elected president he was congratulated in a brief telephone call from Zapatero. Foreign Minister Miguel Ángel Moratinos visited Washington to meet Secretary of State Hillary Clinton a month after the new American administration was inaugurated. Moratinos told reporters that Spain was ready to take some prisoners from the closing Guantanamo Bay detention camp, provided that the judicial conditions were acceptable. Moratinos also commented that "a new stage in relations between the United States and Spain is opening that is more intense, more productive".

Obama and Zapatero met face-to-face for the first time on April 2, 2009, at the G20 London Summit. Both leaders participated in the NATO Summit in Strasbourg-Kehl, where Spain committed an additional 450 troops to its previous military contingent of 778 in Afghanistan. Commentators said the decision may have been partially motivated by the Zapatero government's desire to curry favor with the new administration in Washington. Days later at the EU-U.S. Summit in Prague the two held a 45-minute meeting, and afterwards shared a photo-op for the press, where Obama called Zapatero a friend, and said he thinks that the two nations would establish an even stronger relationship in the years to come. This was the first formal meeting between heads of government of Spain and the United States since 2004.

In February 2010, Obama met with Zapatero at the United States Capitol a few days after Obama announced he would not attend the EU-U.S. summit in Madrid in May. Two weeks later, Obama met with King Juan Carlos I. Juan Carlos I was the first European head of state to meet with Obama in the White House, where he has met with John F. Kennedy in 1962, Gerald Ford in 1976, Ronald Reagan in 1987, and Bill Clinton in 1993.

In June 2018 King Felipe VI and Josep Borrell, minister of Foreign Affairs, Cooperation and European Union, made an official visit to the US. They met President Donald Trump on June 19. Meanwhile, Borrell had a meeting with Secretary of State Mike Pompeo, where the Spanish delegation showed concern for the US protectionist drift and discrepancies between the two countries were found in regards to their approach to migration policies.

On 28 June 2022, following a meeting of US president Joe Biden with Spanish prime minister Pedro Sánchez in La Moncloa, both leaders issued a joint declaration to enhance the relations between both countries (updating the 2001 previous joint declaration signed by Josep Piqué and Madeleine Albright), which included an agreement on increasing the number of US warships in Rota and on the importance of permanent cooperation between both countries in response to the challenges of irregular immigration in North Africa.

Diplomatic missions

Of Spain
 Washington, D.C. (Embassy)
 Boston (Consulate-General)
 Chicago (Consulate-General)
 Houston (Consulate-General)
 Los Angeles (Consulate-General)
 Miami (Consulate-General)
 New York City (Consulate-General)
 San Francisco (Consulate-General)
 San Juan (Consulate-General)

Of United States
 Madrid (Embassy)
 Barcelona (Consulate-General)
 Valencia (Consular Agency)
 Las Palmas (Consular Agency)
 Fuengirola (Consular Agency)
 Palma de Mallorca (Consular Agency)
 Seville (Consular Agency)

Polls
According to 2012 the USA Global Leadership Report, 34% of Spaniards approve of U.S. leadership, with 33% disapproving and 34% uncertain. According to a 2013 BBC World Service Poll, 43% of Spanish people view the US influence positively, with only 25% expressing a negative view. A 2017 survey conducted by the Pew Research Center showed 60% of Spaniards had a negative view of the US, with only 31% having a positive view. The same study also showed only 7% of Spaniards had confidence in President Donald Trump, with 70% having no confidence in him.

Country comparison

See also
 Basque Americans
 List of ambassadors of Spain to the United States
 List of ambassadors of the United States to Spain
 Spanish Americans
 United States Air Forces in Europe
 Anti-American sentiment in Spain
 EU–US relations
 European Union–NATO relations

Informational notes

References

Further reading
 Beevor, Antony, The Battle for Spain (Penguin Books, 2006), on the 1930s
 Bowen, Wayne H. Truman, Franco's Spain, and the Cold War (U of Missouri Press, 2017). 197 pp.
 Byrnes, Mark. "Unfinished business: The United States and Franco's Spain, 1944–47." Diplomacy and Statecraft 11.1 (2000): 129–162.
 Calvo-González, Oscar. "Neither a carrot nor a stick: American foreign aid and economic policymaking in Spain during the 1950s." Diplomatic History (2006) 30#3 pp: 409–438. online
 Chislett, William. "Spain and the United States: So close, yet so far." El Cano Royal Institute Working Papers 23 (2006): 25+ online.
 Cortada, James W. "Diplomatic Relations Between Spain And The United States, 1899–1936" Iberian Studies. 1979, 8#2 pp 54–61.
 García, Óscar J. Martín. "‘The Most Developed of the Underdeveloped Nations’. US Foreign Policy and Student Unrest in 1960s Spain." International History Review (2018).
 Gavin, Victor. "The Nixon and Ford Administrations and the Future of Post-Franco Spain (1970–6)." International History Review 38.5 (2016): 930–942. online
 Halstead, Charles R. "Historians in Politics: Carlton J.H. Hayes as American Ambassador to Spain 1942–45", Journal of Contemporary History (1975): 383–405. in JSTOR
 Hayes, Carlton J.H. Wartime Mission in Spain, 1942–1945 (1945) by the American ambassador; a primary source; online
 Hayes, Carlton J.H. The United States and Spain, an Interpretation (1951)
 Jimenez, Francisco Javier Rodriguez et al., eds. U.S. Public Diplomacy and Democratization in Spain: Selling Democracy? (Palgrave Macmillan, 2015). xii, 237 pp.
 Jones, Nathan. "The importance of the pre September 11 period in explaining Aznar and Blair's adoption of a pro-US foreign policy." International Journal of Iberian Studies 30.1 (2017): 3–19. online
 Justice, David A. "Role of smart power in US–Spain relations, 1969–1986". (PhD Diss. 2020, Oklahoma State U.) online
 Kennedy, Emmet. "Ambassador Carlton J. H. Hayes's Wartime Diplomacy: Making Spain a Haven from Hitler", Diplomatic History (2012) 36#2, pp 237–260. online
 Murphy. J. Carter, and R. Richard Rubottom. Spain and the United States, Since World War II (Praeger, 1984)
 Payne, Stanley G. The Franco Regime: 1936–1975 (University of Wisconsin Press, 1987)
 Pederson, William D. ed. A Companion to Franklin D. Roosevelt (2011) pp 653–671; historiography of FDR's policies
 Powell, Charles T. "The United States and Spain: From Franco to Juan Carlos.” In Spain Transformed: The Late Dictatorship, 1959–75, ed. by Nigel Townson. (Palgrave Macmillan, 2010).

 Puig, Núria, and Adoración Álvaro-Moya. "The long-term effects of foreign investment on local human capital: Four American companies in Spain, 1920s–1970s." Business History Review 92.3 (2018): 425–452. online
 Rodriguez-Jimenez, Francisco, Lorenzo Delgado, and Nicholas J. Cull, eds. U.S. Public Diplomacy and Democratization in Spain: Selling Democracy? (Springer, 2016).
 Rosendorf, N. Franco Sells Spain to America: Hollywood, Tourism and Public Relations as Postwar Spanish (2014)

 Rubio-Varas, M. D. Mar, and Joseba De la Torre. "How did Spain become the major US nuclear client?." in The Economic History of Nuclear Energy in Spain (Palgrave Macmillan, Cham, 2017) pp. 119–153.
 Rubottom, R. Richard, and J. Carter Murphy. Spain and the United States: Since World War II (Praeger, 1984)
 Shneidman, Jerome Lee. Spain & Franco, 1949–59: Quest for international acceptance (1973) online free to borrow
 Solsten, Eric, and Sandra W. Meditz. Spain: A country study (Library of Congress, 1988) online
 Volker, Kurt. "America and Spain: renewing a strategic partnership." Elcano Royal Institute  (2006) online.
 Whitaker, Arthur P. Spain and the Defense of the West: Ally and Liability (1961)
 Woehrel, Steven. "Spain: Current Issues and US Policy." (Washington: Congressional Research Service) 2007) online.

Before 1930s
 Bota, Miquel, and Christopher J Castañeda, eds. Americanized Spanish Culture: Stories and Storytellers of Dislocated Empire (Routledge, 2022)
 Castañeda, Christopher J., and Miquel Bota. "Introduction: Transcultural Bonds and Americanized Spanish Culture." in Americanized Spanish Culture (Routledge, 2022) pp. 1–20.
 Chadwick, French Ensor. The Relations of the United States and Spain: Diplomacy (1909) online. Also online review of the book, a standard scholarly history
 Cortada, James W. "Diplomatic Relations Between Spain and the United States, 1899–1936" Iberian Studies. 1979, 8#2 pp 54–61.
 Cortada, James W. "Spain and the American Civil War: Relations at Mid-Century, 1855–1868." Transactions of the American Philosophical Society 70.4 (1980): 1–121 online.
 Cortada, James W. Two Nations Over Time: Spain and the United States, 1776–1977 (1978)
 Cortada, James W. "Economic Issues in Caribbean Politics: Rivalry between Spain and the United States in Cuba, 1848–1898." Revista de Historia de América 86 (1978): 233–267. online.
 Cortada, James W. "The information ecosystems of national diplomacy: the case of Spain, 1815–1936." Information & Culture 48.2 (2013): 222–259. online
 French, Gregg. "The Writings of US Hispanists and the Malleability of the US Empire's Spanish Past 1." in Spain, the United States, and Transatlantic Literary Culture throughout the Nineteenth Century (Routledge, 2021). 55–78. Focus on Washington Irving and William Hickling Prescott.
 Gilmore, N. Ray. "Mexico and the Spanish-American War." Hispanic American Historical Review  43.4 (1963): 511–525 online.
 Havard, John C. and Ricardo Miguel-Alfonso, eds. Spain, the United States, and Transatlantic Literary Culture throughout the Nineteenth Century (Routledge, 2021) excerpt

 Green, Jennifer R., and Patrick M. Kirkwood. "Reframing the Antebellum Democratic Mainstream: Transatlantic Diplomacy and the Career of Pierre Soulé." Civil War History 61.3 (2015): 212–251.
 Kagan, Richard L. The Spanish Craze: America's Fascination with the Hispanic World, 1779–1939 (U of Nebraska Press, 2019).
 French, Gregg. " 'The Spanish Element in Our Nationality': Spain and America at the World’s Fairs and Centennial Celebrations, 1876–1915." (2021): 119–121. online
 Lozano, Rosina. "The Early Political History of Spanish in the United States." in The Spanish Language in the United States: Rootedness, Racialization, and Resistance (2022): 33–47. excerpt
 Offner, John L. An unwanted war: The diplomacy of the United States and Spain over Cuba, 1895–1898 (1992).
 Sanchez-Padilla, Andres. "The 'friends' of the United States: the transformation of U.S. cultural diplomacy in Spain (1865–1900)." American Nineteenth Century History (2020): 283–300
 Sanjurjo, Jesús. In the Blood of Our Brothers: Abolitionism and the End of the Slave Trade in Spain's Atlantic Empire, 1800–1870 (University of Alabama Press, 2021).
 Wyllys, Rufus Kay. "The East Florida Revolution of 1812–1814." Hispanic American Historical Review 9.4 (1929): 415–445. online

External links
 History of Spain – U.S. relations
  España–EE UU: una historia de amor y odio
 Spain and the United States
 U.S.–Spain Relations: Interview with Daniel Fried, Assistant Secretary for European and Eurasian Affairs, May 25, 2007
 U.S. Mission in Spain
 Ahead of rare talks, Rice slams Spain over Cuba
 Spain welcomes Rice with hope for better ties
 "A Period of Turbulent Change: Spanish-US Relations Since 2002", Manuel Iglesias-Cavicchioli, The Whitehead Journal of Diplomacy and International Relations, Summer/Fall 2007.

United States
Bilateral relations of the United States
Relations of colonizer and former colony


RING finger protein 10 is a protein that in humans is encoded by the RNF10 gene.

Function

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known.

Model organisms

Model organisms have been used in the study of RNF10 function. A conditional knockout mouse line, called Rnf10tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on mutant mice and five significant abnormalities were observed. Homozygous mutant animals displayed increased chromosomal stability in a micronucleus test. Females also had increased body weight,  an increased amount of total body fat and an abnormal complete blood count. Males additionally displayed an increase in eating behavior.

References

Further reading

Genes mutated in mice
RING finger proteins


The Fragrant Hills Pagoda () of the Fragrant Hills in Beijing, China was built in 1780 during the reign of the Qianlong Emperor (1735–1796) as part of the Grand Zongjing Monastery. Although the monastery located just north of the pagoda was burned down by the Eight-Nation Alliance in 1900, the Fragrant Hills Pagoda was unharmed by the nearby fires. The pagoda is octagonal-shaped, 40 m (130 ft) tall with seven stories, and has a stone square-platform at the base to support the structure. The pagoda is adorned with glazed tiles of yellow, green, purple, and blue hues. Surrounding the pagoda at the base is a wooden Chinese pavilion with supporting columns, this structure crowned with a white marble railing and terrace.

External links
Fragrant Hills Pagoda at China.org.cn

Buddhist temples in Beijing
Pagodas in China
Qing dynasty architecture
18th-century Buddhist temples
Religious buildings and structures completed in 1780
Towers completed in 1780
1780s establishments in China


Archibald Kennedy is the name of:

 Archibald Kennedy, 11th Earl of Cassilis (died 1794)
 Archibald Kennedy, 1st Marquess of Ailsa (1770–1846)
 Archibald Kennedy, Earl of Cassilis (1794–1832)
 Archibald Kennedy, 2nd Marquess of Ailsa (1816–1870)
 Archibald Kennedy, 3rd Marquess of Ailsa (1847–1938)
 Archibald Kennedy, 4th Marquess of Ailsa (1872–1943)
 Archibald Kennedy, 7th Marquess of Ailsa (1925–1994)
 Archibald Kennedy, 8th Marquess of Ailsa (1956–2015)

See also
 Archibald M. Kennedy (1818–1897)


The 2008 Monte Carlo Rally, officially 76ème Rallye Automobile de Monte-Carlo, was the 76th Monte Carlo Rally and the first round of the 2008 World Rally Championship season. The rally took place during January 24–27, 2008, beginning with two stages driven in darkness throughout on Thursday and ending with a short super special around the harbour area of the Grand Prix circuit in Monaco on Sunday.

Sébastien Loeb took a record fifth Monte Carlo win for the Citroën Total World Rally Team. Ford's Mikko Hirvonen was second and Subaru's Chris Atkinson third, after a tight battle with François Duval; drivers finished the final Super Special Stage with exact same times and ended the event with just above 1s time gap between them. Petter Solberg was fifth, followed by Gigi Galli, Jean-Marie Cuoq, Per-Gunnar Andersson, Henning Solberg and Matthew Wilson. Dani Sordo and Jari-Matti Latvala both retired from day three, but continued under the SupeRally rules and finished 11th and 12th respectively.

Results

Special stages
All dates and times are CET (UTC+1).

Championship standings after the event

Drivers' championship

Manufacturers' championship

References

External links

 Standings at eWRC

Monte Carlo
2008
Rally
Monte


IQ motif and SEC7 domain-containing protein 1  also known as ARF-GEP100 (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein -  100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

Function
The ARF-GEP100 protein is involved in signal transduction. It is a guanine nucleotide exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5. This activates the ADP-ribosylation activity of the target protein and cause it to modify its substrates. ARF-GEP100, through activation of ARF6, is therefore involved in the control of processes such as endocytosis of plasma membrane proteins, E-cadherin recycling and actin cytoskeleton remodeling. ARF-GEP100 appears particularly important in regulating cell adhesion, with reductions in the level of this protein causing enhanced spreading and attachment of cells.

It is highly expressed in the prefrontal cortex, and throughout the rest of the brain, and is believed to have a role in learning and memory, having been detected as phosphorylated in a phospho screen of the PSD.

References

Further reading

External links


"Tú, sólo tú" (You, Only You) is a ranchera song written by Mexican songwriter Felipe Valdés Leal in 1949. That same year the song was recorded by Miguel Aceves Mejía, Pedro Infante, Luis Pérez Meza and Rosita Quintana.

The song was also included in the films Pueblerina (1949), where it was performed by Roberto Cañedo and Columba Domínguez; Perdida (1950), where it was performed by La Torcacita; and Tú, solo tú (1950), where it was performed by Luis Aguilar.

Selena version

Selena recorded a cover version with the Anglicized spelling "Tu Solo Tu". It is the second single (first in Spanish) released from the album Dreaming of You. Her version was originally recorded for the 1995 film Don Juan DeMarco. It was the first Spanish-language single to be released from Selena's recording projects following her death.

Chart performance
The song debuted at number 3 on the Billboard Hot Latin Tracks for the week of July 15, 1995, and climbed to number 1 the following week where it remained for ten weeks, Selena's longest run at number 1.

The single, "I Could Fall In Love", was kept from reaching the top spot on the chart by "Tú sólo tú", but with this feat, Selena became the second performer ever to have singles in the top two spots of the Hot Latin Tracks chart in the same week (the first being Ana Gabriel).

On the Billboard Latin Regional Mexican Airplay chart, the single debuted and peaked at number one, spending nine weeks at the top.

Charts

Certifications

Personnel
José Hernàndez - producer, arranger
Selena - vocals
Mariachi Sol de México - backing vocals and special guests
Bruce Robb - engineer
Robb Bross - mixer

References

1949 songs
Ranchera songs
Flor Silvestre songs
1995 singles
Selena songs
Songs released posthumously
EMI Records singles


Quinone oxidoreductase-like protein 1 is an enzyme that in humans is encoded by the CRYZL1 gene.

This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined.

References

External links

Further reading


Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene.
Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein  and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.

References

Further reading


Polisi Tanzania (Polisi Morogoro) is a Tanzanian football club in Moshi, Kilimanjaro.

The 2015/16 season they are playing in the Tanzanian First Division League. They previously played in the top level of Tanzanian professional football, the Tanzanian Premier League.

References

Football clubs in Tanzania
Morogoro
Kilimanjaro Region
Morogoro


Leirsund Station is a railway station at Leirsund in Skedsmo, Norway on the Trunk Line. It is served by an hourly services, R13 by Vy. The station was opened in 1859, five years after the rest of Hovedbanen. When the Gardermoen Line was built in 1998 Leirsund was rebuilt and slightly moved.

External links

Railway stations on the Trunk Line
Railway stations in Skedsmo
Railway stations in Norway opened in 1859


The Neva River is a river in northwestern Russia.

Neva may also refer to:

Places
Neva, Mazandaran, a village in Iran
Neva, Wisconsin, a town in Langlade County, Wisconsin, United States
Neva (community), Wisconsin, an unincorporated community
Neva Shoal, a shoal in Hawaii
Mount Neva (Colorado)
Mount Neva (Nevada)
Neva Bay, the easternmost part of the Gulf of Finland
Neva (Italy), a short river in Liguria, Italy

Military
Neva, a Russian codename for the Soviet S-125 Neva/Pechora surface-to-air missile system
Battle of the Neva, a 1240 battle which may not have taken place
Battle of the Neva (1708), during the Swedish invasion of Russia

People
Neva (name), a list of people with either the given name or surname

Other uses
Neva  (1802 Russian ship), a ship originally called Thames, purchased and renamed by the Russians
Neva  (1813 ship), a three-masted English barque
Nihon Ethics of Video Association, also known as "Viderin"/"Biderin", a former ratings organization of the Japanese video industry
Neva (horse), a British Thoroughbred racehorse
Neva Cup, a professional women's tennis tournament in Russia
Neva Foundation, a Swiss non-profit organization promoting cultural and scientific exchanges between Russia and Switzerland
Neva (magazine), a Russian monthly literary magazine first published in 1955
Neva Towers, a building complex consisting of two skyscrapers in Moscow, Russia


The following article presents a summary of the 1907 football (soccer) season in Brazil, which was the 6th season of competitive football in the country.

Campeonato Paulista

Final Standings

SC Internacional de São Paulo declared as the Campeonato Paulista champions.

State championship champions

(1)In 1997, Fluminense and Botafogo were declared as the 1907 Rio de Janeiro State Championship champions.

References

 Brazilian competitions at RSSSF

Seasons in Brazilian football
Brazil


The Florida Law Review is a bimonthly law review published by the University of Florida's Fredric G. Levin College of Law. The review was established in 1948 as the University of Florida Law Review and it assumed its current name in 1989. It is produced by about eighty student members and two staff assistants. The journal publishes articles, essays, and lectures.

Abstracting and indexing
The journal is abstracted and indexed in EBSCO databases, HeinOnline, and ProQuest databases.

References

External links

American law journals
General law journals
University of Florida
Academic journals established in 1948
Bimonthly journals
English-language journals
1948 establishments in Florida


The 1979–80 Iowa Hawkeyes men's basketball team represented the University of Iowa as a member of the Big Ten Conference during the 1979–80 college basketball season. The team was led by head coach Lute Olson and played their home games at the Iowa Field House. They finished with a 23–10 (10–8 Big Ten) record, and reached the Final Four of the NCAA tournament as champions of the East Region. To date, this is Iowa's most recent appearance in the NCAA Final Four in men's basketball.

Roster

Schedule and results

|-
!colspan=9 style=| Regular season

|-
!colspan=9 style=|NCAA Tournament

Rankings

Team players in the 1980 NBA draft

References

Iowa
Iowa Hawkeyes men's basketball seasons
NCAA Division I men's basketball tournament Final Four seasons
Iowa
Hawkeyes
Hawkeyes


Fruita is the best-known settlement in Capitol Reef National Park in Wayne County, Utah, United States. It is located at the confluence of Fremont River and Sulphur Creek.
Despite its status as ghost town, it is the location of the National Park Service's employee residences.

History
Fruita was established in 1880 by a group of Mormons led by Nels Johnson, under the name Junction. The town became known as Fruita in 1902 or 1904. In 1900, Fruita was named The Eden of Wayne County for its large orchards. Fruita was abandoned in 1955 when the National Park Service purchased the town to be included in Capitol Reef National Park.

Today few buildings remain, except for the restored schoolhouse and the Gifford house and barn. The orchards remain, now under the ownership of the National Park Service, and have about 2,500 trees. The orchards are preserved by the NPS as a "historic landscape" and a small crew takes care of them by pruning, irrigating, replanting, and spraying them.

The one-room schoolhouse was built and opened in 1896. The few students were instructed mainly in reading, writing, and arithmetic, but when the teachers were capable, they also studied other subjects such as history or geography. The room was also used for balls and religious services. It was renovated in 1966 by the National Park Service.

Fruita is currently the heart and administrative center of Capitol Reef National Park.

See also
Fruita Schoolhouse

Popular culture
 Used as the setting for Western Five Bloody Graves 1970, according to DVD audio commentary.

Climate
According to the Köppen Climate Classification system, Fruita has a semi-arid climate, abbreviated "BSk" on climate maps.

References

External links

Capitol Reef National Park
Ghost towns in Utah
Populated places established in 1880
1880 establishments in Utah Territory
Ghost towns in Wayne County, Utah


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The Holloway's Hurdle is a Class 2 National Hunt hurdle race in Great Britain which is open to horses aged four years or older. It is run at Ascot over a distance of about 2 miles and 3½ furlongs (2 miles 3 furlongs and 58 yards, or 3,875 metres), and during its running there are ten hurdles to be jumped. It is a handicap race, and it is scheduled to take place each year in January. Prior to 2016 it was run as handicap with a limited weight race and carried Grade 2 status, after which it was demoted to Grade 3 status until 2022.

Winners
 Weights given in stones and pounds.

See also
 Horse racing in Great Britain
 List of British National Hunt races

References
 Racing Post:
 , , , , , , , , ,
 ,

 pedigreequery.com – Holloway's Hurdle – Ascot.

National Hunt races in Great Britain
Ascot Racecourse
National Hunt hurdle races


Joseph Gottlieb Kölreuter (27 April 1733 – 11 November 1806), also spelled Koelreuter or Kohlreuter, was a German botanist who pioneered the study of plant fertilization, hybridization and was the first to detect self-incompatibility. He was an observer as well as a rigorous experimenter who used careful crossing experiments although he did not inquire into the nature of heritability.

Biography
Kölreuter was the oldest of three sons of an apothecary in Karlsruhe, Germany, and grew up in Sulz. He took an early interest in natural history and made a collection of local insects. At the age of fifteen he went to study medicine at the University of Tübingen under physician and botanist Johann Georg Gmelin who had returned from St. Petersburg. Gmelin had an interest in floral biology and he reprinted a work by Rudolf Jakob Camerarius (who also taught at Tübingen) who was the first to demonstrate sexual reproduction in plants. In his inaugural address in 1749 Gmelin talked the need for research on the origin of new species by hybridization. This may have had an influence on Kölreuter. Gmelin died in 1755, and Kolreuter earned his degree and received an appointment at the Imperial Academy of Sciences at St. Petersburg on 23 December 1755. Here his work included botany as well as the curation of the fish and coral collections. He stayed on until 6 June 1761. From 1759 he experimented on plant hybridization before returning to Germany. He moved to Calw in 1763 and Karlsruhe in 1764 where he was briefly professor of natural history and director of the botanical garden at Baden. He was dismissed from the botanical garden after a dispute with the head gardener in 1783 but stayed as a professor until 1806 when he died.

Researches

Kölreuter followed the standard idea of the period of plants and nature personified by a Creator. He expected patterns, for instance, homogeneity in the male and female contributions to the progeny. He also strongly believed in epigenetic influences which may have been derived from the teachings of C. F. Wolff. The dominant belief during his time was that an offspring was already preformed in the female or the male and that the embryo was developed after sex and the origin decided the offspring's characteristics or similarities to the parent. Kölreuter, however noted a mixing of characters and proposed the idea of “seed matters” (Saamenstoffe). According to Kölreuter there had to be two uniform fluids, male and female semen which combined in the process of fertilization. He believed that equal quantities of the male and female fluid were needed and he therefore examined how much pollen was needed in fertilization of a given number of seeds. In flowers with multiple stigmas, he cut all but one and found that pollinating it was enough to fertilize all the seeds. He examined the action of stigma fluid on pollen, described many plant species, and studied pollen and its transfer.

Kölreuter's major works were produced as four reports Vorlaufige Nachricht von einigen das Geschlecht der Pflanzen betreffenden Versuchen und Beobachtungen (1761), Fortsetzung (1763), Zweyte Fortsetzung (1764), and Dritte Fortsetzung (1766). They were reprinted in 1893 in Wilhelm Ostwald's Klassiker der exakten Wissenschaften. Kolreuter's findings are not reported in easy to read sections but are distributed throughout the text. Many parts have not been fully translated to English and this has led to many of the results not being examined well. In all he conducted nearly 500 different hybridization experiments across 138 species and examined the pollen characteristics of over a 1000 plant species. The first documentation of male sterility in 1763 was by Kölreuter, who observed anther abortion within species and specific hybrids. Koelreuter was the first who reported self-incompatibility in Verbascum phoeniceum plants. He also observed heterosis, that hybrids surpassed their parents. His experimental method included repetitions and controls. He wanted to test if hybrids across species could be fertile. Buffon had used the idea of sterility of crosses as a method of testing species boundaries. Buffon used sterility versus fertility as a criterion for species but he gave up the idea in 1753 when he found fertile hybrids in domestic animals and cagebirds. Linnaeus through his student J. J. Hartmann reported the possibility of new "species" arising from hybridization but Kölreuter was skeptical of the results. In one experiment Kölreuter sat beside a flower from dawn to dusk and shooed away all insects to find that the flower remained unfertilized. He tested a hypothesis by Jan Swammerdam that honey was nectar that underwent fermentation in the crop of a bee. Kölreuter collected nectar from many hundreds of orange trees and kept them in vials to evaporate and he reported that it thickened and tasted like honey with time. Kölreuter  produced interspecific hybrids - specifically the tobacco plants Nicotiana rustica and Nicotiana paniculata in 1760. The hybrids showed male sterility. He also worked on Dianthus and Verbascum. He found that reciprocal crossing produced identical results. He also pondered over the commercial applications of hybridization - "I would wish that I or somebody else would be so lucky someday to produce a species hybrid of trees which, with respect to the use of its lumber, would have a large influence on the economy. Among other  good properties such trees might perhaps also have the one that they would reach their full size in one half of the time of normal trees" (translated by Ernst Mayr). Although Kölreuter conducted a variety of repeated crossing experiments much in the manner of Gregor Mendel, his interpretations were based on alchemical notions and he did not seek to examine the nature of heritability or the particulateness of heritable traits.  Kölreuter followed an idea from alchemistry that metals were a mixture of mercury and sulphur and considered likewise that an equilibrium of the male and female "seed matters" had a role in deciding the qualities of hybrid offspring.

Although Koelreuter did not endorse the transmutation of species, his hybridisation research influenced the development of evolutionary theory in the eighteenth century.

The genus Koelreuteria has been named in his honour.

Works
 Dissertatio inauguralis medica de insectis coleopteris, nec non de plantis quibusdam rarioribus... Tubingae: litteris Erhardianis (1755)
 Vorläufige Nachricht von einigen, das Geschlecht der Pflanzen betreffenden Versuchen (1761-1766)
 Das entdeckte Geheimniss der Cryptogamie (1777)

References

Bibliography

External links
 Digital reproductions of Kölreuter's works

1733 births
1806 deaths
18th-century German botanists
People from Sulz am Neckar
Proto-evolutionary biologists


Hellmaster (also known as Soulstealer) is a 1992 American horror film written and directed by Douglas Shulze, and starring John Saxon. The plot follows a psychotic college professor who uses unsuspecting students as laboratory rats, injecting them with a drug that mutates them into brutal killers.

Plot
Part of a secret government eugenics project, crazed biochemistry professor Jones (John Saxon) committed terrible crimes on his college campus in the late 1960s before one of his colleagues burned the college to put a deadly end to his spree. Jones is presumed dead, but a series of murders twenty years later raises questions of whether he has somehow managed to return. In actuality, Jones's drug experiments have turned him into a superhuman. Having teleported himself to safety during the fire, he has been living underground continuing his experiments. With an injection, he is able to turn people into mutants who will follow his will. With the help of his zombie-like army, Jones plans to access his stores of his "Nietzsche Drug" in the catacombs beneath the campus. Standing against him are three people: a psychic, a reporter and a woman who has already survived one supernatural attack. The psychic determines that she herself must take the Nietzsche Drug so she can face the mad professor and his mutant slaves.

Cast
 John Saxon as Professor Jones
 David Emge as Reporter
 Jeff Rector as Jesse
 Amy Raasch as Shelley
 Edward Stevens as Drake
 Sean Sweeney as Joel
 Melissa Zafarana as Tracy
 Jim Riethmiller as Harrold
 Sarah Barkoff as Little Girl

Home media

The film's initial home video release VHS was distributed through AIP in 1992.

The film was released on DVD on September 19, 2006 and includes audio commentary from director Shulze and one of the producers, along with a conceptual art gallery, and a behind-the-scenes gallery.

References

External links

 New York Times overview

1992 films
1992 horror films
1990s psychological thriller films
American supernatural horror films
1990s English-language films
1990s American films


The OMEGA Tag Team Championship is the top tag team title in the Organization of Modern Extreme Grappling Arts independent professional wrestling promotion.

Title history
As of  , .

Combined reigns
As of  , .

By team

By Wrestler

References

External links
 Omega Tag Team Championship

OMEGA Championship Wrestling championships
Tag team wrestling championships


Ellen DeGeneres: Here and Now is a stand-up comedy routine that was shown on HBO. This was Ellen DeGeneres's second HBO special. This hour-long special focused on everyday situations, as DeGeneres put it: modern life and other inconveniences. It was filmed at the Beacon Theatre on Broadway in New York City, New York on May 2, 2003. The show first aired on June 25, 2003.

Subjects addressed
 Procrastination
 Television
 Cellular Phone Conversations
 Self-esteem
 Laziness
 Yogurt
 Movie Theaters
 Embarrassing Situations
 Etiquette

References

External links

 DeGeneres - Stand Up Comedy

2003 television specials
2000s American television specials
Here and Now
HBO network specials
Stand-up comedy concert films
2003 comedy films
2003 films
Films directed by Joel Gallen