Update README.md

README.md

@@ -9,245 +9,293 @@ tags:
 - loss:MultipleNegativesRankingLoss
 base_model: thenlper/gte-small
 widget:
-- source_sentence: Integrated health care for infectious diseases and non-communicable
-    diseases in low-and middle-income countries
+- source_sentence: >-
+    Integrated health care for infectious diseases and non-communicable diseases
+    in low-and middle-income countries
   sentences:
-  - 'The purposes of this study were to create a new flow-chart of prehospital electrocardiography
-    (ECG)-transmission, evaluate its predictive ability for ST-elevation myocardial
-    infarction (STEMI) and shorten door-to-balloon time (DTBT). The new transmission
-    flow-chart was created using symptoms from previous medical records of STEMI patients.
-    A total of 4090 consecutive patients transferred emergently to our hospital were
-    divided into two groups: those in ambulances with an ECG-transmission device with
-    the new flow-chart (ECGT-FC) and those transferred without an ECG-transmission
-    device (non-ECGT) groups. A STEMI group comprising walk-in patients during the
-    same period was used as a control group. The predictive ability of STEMI and the
-    effectiveness of shortening the DTBT by the new flow-chart of ECG-transmission
-    was evaluated. In the ECGT-FC group, the prevalence of STEMI in the ECG-transmission
-    by the new flow-chart were significantly higher than in the non-ECG-transmission
-    patients (6.71% vs. 0.19%; p<0.001). The sensitivity and specificity of the new
-    ECG-transmission flow-chart were 83.3% and 88.1%, respectively. The median DTBT
-    was significantly shortened (p=0.045) and the prevalence of DTBT<90min was significantly
-    higher in the ECGT-FC group (p=0.018) than the other groups. The sensitivity and
-    specificity of the new flow-chart for ECG-transmission were high. The new flow-chart
-    combined with an ECG-transmission device could detect STEMI efficiently and shorten
-    DTBT.'
-  - 'Multiple strains of the SARS-CoV-2 have arisen and jointly influence the trajectory
-    of the coronavirus disease (COVID-19) pandemic. However, current models rarely
-    account for this multi-strain dynamics and their different transmission rate and
-    response to vaccines. We propose a new mathematical model that accounts for two
-    virus variants and the deployment of a vaccination program. To demonstrate utility,
-    we applied the model to determine the control reproduction number '
-  - The co-occurrence of infectious diseases (ID) and non-communicable diseases (NCD)
-    is widespread, presenting health service delivery challenges especially in low-and
-    middle-income countries (LMICs). Integrated health care is a possible solution
-    but may require a paradigm shift to be successfully implemented. This literature
-    review identifies integrated care examples among selected ID and NCD dyads. We
-    searched PubMed, PsycINFO, Cochrane Library, CINAHL, Web of Science, EMBASE, Global
-    Health Database, and selected clinical trials registries. Eligible studies were
-    published between 2010 and December 2022, available in English, and report health
-    service delivery programs or policies for the selected disease dyads in LMICs.
-    We identified 111 studies that met the inclusion criteria, including 56 on tuberculosis
-    and diabetes integration, 46 on health system adaptations to treat COVID-19 and
-    cardiometabolic diseases, and 9 on COVID-19, diabetes, and tuberculosis screening.
-    Prior to the COVID-19 pandemic, most studies on diabetes-tuberculosis integration
-    focused on clinical service delivery screening. By far the most reported health
-    system outcomes across all studies related to health service delivery (n = 72),
-    and 19 addressed health workforce. Outcomes related to health information systems
-    (n = 5), leadership and governance (n = 3), health financing (n = 2), and essential
-    medicines (n = 4)) were sparse. Telemedicine service delivery was the most common
-    adaptation described in studies on COVID-19 and either cardiometabolic diseases
-    or diabetes and tuberculosis. ID-NCD integration is being explored by health systems
-    to deal with increasingly complex health needs, including comorbidities. High
-    excess mortality from COVID-19 associated with NCD-related comorbidity prompted
-    calls for more integrated ID-NCD surveillance and solutions. Evidence of clinical
-    integration of health service delivery and workforce has grown-especially for
-    HIV and NCDs-but other health system building blocks, particularly access to essential
-    medicines, health financing, and leadership and governance, remain in disease
-    silos.
-- source_sentence: Foot-and-mouth disease virus 3C(pro) inhibits interferon-/ response
-    and expression of IFN-stimulated genes
+  - >-
+    The purposes of this study were to create a new flow-chart of prehospital
+    electrocardiography (ECG)-transmission, evaluate its predictive ability for
+    ST-elevation myocardial infarction (STEMI) and shorten door-to-balloon time
+    (DTBT). The new transmission flow-chart was created using symptoms from
+    previous medical records of STEMI patients. A total of 4090 consecutive
+    patients transferred emergently to our hospital were divided into two
+    groups: those in ambulances with an ECG-transmission device with the new
+    flow-chart (ECGT-FC) and those transferred without an ECG-transmission
+    device (non-ECGT) groups. A STEMI group comprising walk-in patients during
+    the same period was used as a control group. The predictive ability of STEMI
+    and the effectiveness of shortening the DTBT by the new flow-chart of
+    ECG-transmission was evaluated. In the ECGT-FC group, the prevalence of
+    STEMI in the ECG-transmission by the new flow-chart were significantly
+    higher than in the non-ECG-transmission patients (6.71% vs. 0.19%; p<0.001).
+    The sensitivity and specificity of the new ECG-transmission flow-chart were
+    83.3% and 88.1%, respectively. The median DTBT was significantly shortened
+    (p=0.045) and the prevalence of DTBT<90min was significantly higher in the
+    ECGT-FC group (p=0.018) than the other groups. The sensitivity and
+    specificity of the new flow-chart for ECG-transmission were high. The new
+    flow-chart combined with an ECG-transmission device could detect STEMI
+    efficiently and shorten DTBT.
+  - >-
+    Multiple strains of the SARS-CoV-2 have arisen and jointly influence the
+    trajectory of the coronavirus disease (COVID-19) pandemic. However, current
+    models rarely account for this multi-strain dynamics and their different
+    transmission rate and response to vaccines. We propose a new mathematical
+    model that accounts for two virus variants and the deployment of a
+    vaccination program. To demonstrate utility, we applied the model to
+    determine the control reproduction number 
+  - >-
+    The co-occurrence of infectious diseases (ID) and non-communicable diseases
+    (NCD) is widespread, presenting health service delivery challenges
+    especially in low-and middle-income countries (LMICs). Integrated health
+    care is a possible solution but may require a paradigm shift to be
+    successfully implemented. This literature review identifies integrated care
+    examples among selected ID and NCD dyads. We searched PubMed, PsycINFO,
+    Cochrane Library, CINAHL, Web of Science, EMBASE, Global Health Database,
+    and selected clinical trials registries. Eligible studies were published
+    between 2010 and December 2022, available in English, and report health
+    service delivery programs or policies for the selected disease dyads in
+    LMICs. We identified 111 studies that met the inclusion criteria, including
+    56 on tuberculosis and diabetes integration, 46 on health system adaptations
+    to treat COVID-19 and cardiometabolic diseases, and 9 on COVID-19, diabetes,
+    and tuberculosis screening. Prior to the COVID-19 pandemic, most studies on
+    diabetes-tuberculosis integration focused on clinical service delivery
+    screening. By far the most reported health system outcomes across all
+    studies related to health service delivery (n = 72), and 19 addressed health
+    workforce. Outcomes related to health information systems (n = 5),
+    leadership and governance (n = 3), health financing (n = 2), and essential
+    medicines (n = 4)) were sparse. Telemedicine service delivery was the most
+    common adaptation described in studies on COVID-19 and either
+    cardiometabolic diseases or diabetes and tuberculosis. ID-NCD integration is
+    being explored by health systems to deal with increasingly complex health
+    needs, including comorbidities. High excess mortality from COVID-19
+    associated with NCD-related comorbidity prompted calls for more integrated
+    ID-NCD surveillance and solutions. Evidence of clinical integration of
+    health service delivery and workforce has grown-especially for HIV and
+    NCDs-but other health system building blocks, particularly access to
+    essential medicines, health financing, and leadership and governance, remain
+    in disease silos.
+- source_sentence: >-
+    Foot-and-mouth disease virus 3C(pro) inhibits interferon-/ response and
+    expression of IFN-stimulated genes
   sentences:
-  - Repeated bottleneck passages of RNA viruses result in accumulation of mutations
-    and fitness decrease. Here, we show that clones of foot-and-mouth disease virus
-    (FMDV) subjected to bottleneck passages, in the form of plaque-to-plaque transfers
-    in BHK-21 cells, increased the thermosensitivity of the viral clones. By constructing
-    infectious FMDV clones, we have identified the amino acid substitution M54I in
-    capsid protein VP1 as one of the lesions associated with thermosensitivity. M54I
-    affects processing of precursor P1, as evidenced by decreased production of VP1
-    and accumulation of VP1 precursor proteins. The defect is enhanced at high temperatures.
-    Residue M54 of VP1 is exposed on the virion surface, and it is close to the B-C
-    loop where an antigenic site of FMDV is located. M54 is not in direct contact
-    with the VP1-VP3 cleavage site, according to the three-dimensional structure of
-    FMDV particles. Models to account for the effect of M54 in processing of the FMDV
-    polyprotein are proposed. In addition to revealing a distance effect in polyprotein
-    processing, these results underline the importance of pursuing at the biochemical
-    level the biological defects that arise when viruses are subjected to multiple
-    bottleneck events.
-  - To improve the delivery of liposomes to tumors using P-selectin glycoprotein ligand
-    1 (PSGL1) mediated binding to selectin molecules, which are upregulated on tumorassociated
-    endothelium.
-  - Foot-and-mouth disease is a highly contagious viral illness of wild and domestic
-    cloven-hoofed animals. The causative agent, foot-and-mouth disease virus (FMDV),
-    replicates rapidly, efficiently disseminating within the infected host and being
-    passed on to susceptible animals via direct contact or the aerosol route. To survive
-    in the host, FMDV has evolved to block the host interferon (IFN) response. Previously,
-    we and others demonstrated that the leader proteinase (L(pro)) of FMDV is an IFN
-    antagonist. Here, we report that another FMDV-encoded proteinase, 3C(pro), also
-    inhibits IFN-α/β response and the expression of IFN-stimulated genes. Acting in
-    a proteasome- and caspase-independent manner, the 3C(pro) of FMDV proteolytically
-    cleaved nuclear transcription factor kappa B (NF-κB) essential modulator (NEMO),
-    a bridging adaptor protein essential for activating both NF-κB and interferon-regulatory
-    factor signaling pathways. 3C(pro) specifically targeted NEMO at the Gln 383 residue,
-    cleaving off the C-terminal zinc finger domain from the protein. This cleavage
-    impaired the ability of NEMO to activate downstream IFN production and to act
-    as a signaling adaptor of the RIG-I/MDA5 pathway. Mutations specifically disrupting
-    the cysteine protease activity of 3C(pro) abrogated NEMO cleavage and the inhibition
-    of IFN induction. Collectively, our data identify NEMO as a substrate for FMDV
-    3C(pro) and reveal a novel mechanism evolved by a picornavirus to counteract innate
-    immune signaling.
+  - >-
+    Repeated bottleneck passages of RNA viruses result in accumulation of
+    mutations and fitness decrease. Here, we show that clones of foot-and-mouth
+    disease virus (FMDV) subjected to bottleneck passages, in the form of
+    plaque-to-plaque transfers in BHK-21 cells, increased the thermosensitivity
+    of the viral clones. By constructing infectious FMDV clones, we have
+    identified the amino acid substitution M54I in capsid protein VP1 as one of
+    the lesions associated with thermosensitivity. M54I affects processing of
+    precursor P1, as evidenced by decreased production of VP1 and accumulation
+    of VP1 precursor proteins. The defect is enhanced at high temperatures.
+    Residue M54 of VP1 is exposed on the virion surface, and it is close to the
+    B-C loop where an antigenic site of FMDV is located. M54 is not in direct
+    contact with the VP1-VP3 cleavage site, according to the three-dimensional
+    structure of FMDV particles. Models to account for the effect of M54 in
+    processing of the FMDV polyprotein are proposed. In addition to revealing a
+    distance effect in polyprotein processing, these results underline the
+    importance of pursuing at the biochemical level the biological defects that
+    arise when viruses are subjected to multiple bottleneck events.
+  - >-
+    To improve the delivery of liposomes to tumors using P-selectin glycoprotein
+    ligand 1 (PSGL1) mediated binding to selectin molecules, which are
+    upregulated on tumorassociated endothelium.
+  - >-
+    Foot-and-mouth disease is a highly contagious viral illness of wild and
+    domestic cloven-hoofed animals. The causative agent, foot-and-mouth disease
+    virus (FMDV), replicates rapidly, efficiently disseminating within the
+    infected host and being passed on to susceptible animals via direct contact
+    or the aerosol route. To survive in the host, FMDV has evolved to block the
+    host interferon (IFN) response. Previously, we and others demonstrated that
+    the leader proteinase (L(pro)) of FMDV is an IFN antagonist. Here, we report
+    that another FMDV-encoded proteinase, 3C(pro), also inhibits IFN-α/β
+    response and the expression of IFN-stimulated genes. Acting in a proteasome-
+    and caspase-independent manner, the 3C(pro) of FMDV proteolytically cleaved
+    nuclear transcription factor kappa B (NF-κB) essential modulator (NEMO), a
+    bridging adaptor protein essential for activating both NF-κB and
+    interferon-regulatory factor signaling pathways. 3C(pro) specifically
+    targeted NEMO at the Gln 383 residue, cleaving off the C-terminal zinc
+    finger domain from the protein. This cleavage impaired the ability of NEMO
+    to activate downstream IFN production and to act as a signaling adaptor of
+    the RIG-I/MDA5 pathway. Mutations specifically disrupting the cysteine
+    protease activity of 3C(pro) abrogated NEMO cleavage and the inhibition of
+    IFN induction. Collectively, our data identify NEMO as a substrate for FMDV
+    3C(pro) and reveal a novel mechanism evolved by a picornavirus to counteract
+    innate immune signaling.
 - source_sentence: Measuring flourishing among adolescent and adult populations
   sentences:
-  - Flourishing is an evolving wellbeing construct and outcome of interest across
-    the social and biological sciences. Despite some conceptual advancements, there
-    remains limited consensus on how to measure flourishing, as well as how to distinguish
-    it from closely related wellbeing constructs, such as thriving and life satisfaction.
-    This paper aims to provide an overview and comparison of the diverse scales that
-    have been developed to measure flourishing among adolescent and adult populations
-    to provide recommendations for future studies seeking to use flourishing as an
-    outcome in social and biological research.
-  - Although well-being at work is important for occupational health, multi-dimensional
-    workplace well-being measures do not exist for Japanese workers. The purpose of
-    this study was to investigate the validity of the Japanese version of the Workplace
-    PERMA-Profiler. Japanese workers completed online surveys at baseline (N = 310)
-    and 1 month later (N = 100). The Workplace PERMA-Profiler was translated according
-    to international guidelines. Job and life satisfaction, work engagement, psychological
-    distress, work-related psychosocial factors, and work performance were measured
-    as comparisons for convergent validity. Cronbach's alphas, Intra-class Correlation
-    Coefficients (ICCs), and measurement errors were calculated for the reliability,
-    and the validity of the measure was tested by correlational analyses and confirmatory
-    factor analysis. A total of 310 (baseline) and 86 (follow-up) workers responded
-    and were included in the analyses. Cronbach's alphas and ICCs of the Japanese
-    Workplace PERMA-Profiler ranged from 0.75 to 0.96. Confirmatory factor analysis
-    indicated that the 5-factor model demonstrated a marginally acceptable fit (χ2
-    (80) = 351.30, CFI = 0.892, TLI = 0.858, RMSEA = 0.105, SRMR = 0.051). Overall
-    well-being and the five PERMA domains had moderate-to-strong correlations with
-    job satisfaction, psychological distress (inversely), and work-related factors.
-    The Japanese version of the Workplace PERMA-Profiler demonstrated adequate reliability
-    and validity. This measure could be useful to assess well-being at work, promote
-    well-being research among Japanese workers, and address the problem of definition
-    for well-being in further studies.
-  - We experience countless pieces of new information each day, but remembering them
-    later depends on firmly instilling memory storage in the brain. Numerous studies
-    have implicated non-rapid eye movement (NREM) sleep in consolidating memories
-    via interactions between hippocampus and cortex. However, the temporal dynamics
-    of this hippocampal-cortical communication and the concomitant neural oscillations
-    during memory reactivations remains unclear. To address this issue, the present
-    study used the procedure of targeted memory reactivation (TMR) following learning
-    of object-location associations to selectively reactivate memories during human
-    NREM sleep. Cortical pattern reactivation and hippocampal-cortical coupling were
-    measured with intracranial EEG recordings in patients with epilepsy. We found
-    that TMR produced variable amounts of memory enhancement across a set of object-location
-    associations. Successful TMR increased hippocampal ripples and cortical spindles,
-    apparent during two discrete sweeps of reactivation. The first reactivation sweep
-    was accompanied by increased hippocampal-cortical communication and hippocampal
-    ripple events coupled to local cortical activity (cortical ripples and high-frequency
-    broadband activity). In contrast, hippocampal-cortical coupling decreased during
-    the second sweep, while increased cortical spindle activity indicated continued
-    cortical processing to achieve long-term storage. Taken together, our findings
-    show how dynamic patterns of item-level reactivation and hippocampal-cortical
-    communication support memory enhancement during NREM sleep.
-- source_sentence: Agrobacterium tumefaciens Hfq binds to sRNA AbcR1 and its target
-    mRNA atu2422
+  - >-
+    Flourishing is an evolving wellbeing construct and outcome of interest
+    across the social and biological sciences. Despite some conceptual
+    advancements, there remains limited consensus on how to measure flourishing,
+    as well as how to distinguish it from closely related wellbeing constructs,
+    such as thriving and life satisfaction. This paper aims to provide an
+    overview and comparison of the diverse scales that have been developed to
+    measure flourishing among adolescent and adult populations to provide
+    recommendations for future studies seeking to use flourishing as an outcome
+    in social and biological research.
+  - >-
+    Although well-being at work is important for occupational health,
+    multi-dimensional workplace well-being measures do not exist for Japanese
+    workers. The purpose of this study was to investigate the validity of the
+    Japanese version of the Workplace PERMA-Profiler. Japanese workers completed
+    online surveys at baseline (N = 310) and 1 month later (N = 100). The
+    Workplace PERMA-Profiler was translated according to international
+    guidelines. Job and life satisfaction, work engagement, psychological
+    distress, work-related psychosocial factors, and work performance were
+    measured as comparisons for convergent validity. Cronbach's alphas,
+    Intra-class Correlation Coefficients (ICCs), and measurement errors were
+    calculated for the reliability, and the validity of the measure was tested
+    by correlational analyses and confirmatory factor analysis. A total of 310
+    (baseline) and 86 (follow-up) workers responded and were included in the
+    analyses. Cronbach's alphas and ICCs of the Japanese Workplace
+    PERMA-Profiler ranged from 0.75 to 0.96. Confirmatory factor analysis
+    indicated that the 5-factor model demonstrated a marginally acceptable fit
+    (χ2 (80) = 351.30, CFI = 0.892, TLI = 0.858, RMSEA = 0.105, SRMR = 0.051).
+    Overall well-being and the five PERMA domains had moderate-to-strong
+    correlations with job satisfaction, psychological distress (inversely), and
+    work-related factors. The Japanese version of the Workplace PERMA-Profiler
+    demonstrated adequate reliability and validity. This measure could be useful
+    to assess well-being at work, promote well-being research among Japanese
+    workers, and address the problem of definition for well-being in further
+    studies.
+  - >-
+    We experience countless pieces of new information each day, but remembering
+    them later depends on firmly instilling memory storage in the brain.
+    Numerous studies have implicated non-rapid eye movement (NREM) sleep in
+    consolidating memories via interactions between hippocampus and cortex.
+    However, the temporal dynamics of this hippocampal-cortical communication
+    and the concomitant neural oscillations during memory reactivations remains
+    unclear. To address this issue, the present study used the procedure of
+    targeted memory reactivation (TMR) following learning of object-location
+    associations to selectively reactivate memories during human NREM sleep.
+    Cortical pattern reactivation and hippocampal-cortical coupling were
+    measured with intracranial EEG recordings in patients with epilepsy. We
+    found that TMR produced variable amounts of memory enhancement across a set
+    of object-location associations. Successful TMR increased hippocampal
+    ripples and cortical spindles, apparent during two discrete sweeps of
+    reactivation. The first reactivation sweep was accompanied by increased
+    hippocampal-cortical communication and hippocampal ripple events coupled to
+    local cortical activity (cortical ripples and high-frequency broadband
+    activity). In contrast, hippocampal-cortical coupling decreased during the
+    second sweep, while increased cortical spindle activity indicated continued
+    cortical processing to achieve long-term storage. Taken together, our
+    findings show how dynamic patterns of item-level reactivation and
+    hippocampal-cortical communication support memory enhancement during NREM
+    sleep.
+- source_sentence: >-
+    Agrobacterium tumefaciens Hfq binds to sRNA AbcR1 and its target mRNA
+    atu2422
   sentences:
-  - Amyloid β (Aβ) assemblies exist not only in the central nervous system, but can
-    circulate within the bloodstream to trigger and exacerbate peripheral, cerebrovascular,
-    and neurodegenerative disorders. Eliminating excess peripheral Aβ fibrils, therefore,
-    holds promise to improve the management of amyloid-related diseases. Here, we
-    present nanoemulsion-mediated ultrasonic ablation of circulating Aβ fibrils to
-    both destroy established plaques and prevent the re-growth of ablated fragments
-    back into toxic species. This approach is made possible using a de novo designed
-    peptide emulsifier that contains the self-associating sequence from the amyloid
-    precursor protein. Emulsification of the peptide surfactant with fluorous nanodroplets
-    produces contrast agents that rapidly adsorb Aβ assemblies and allows their ultrasound-controlled
-    destruction via acoustic cavitation. Vessel-mimetic flow experiments demonstrate
-    that nanoemulsion-assisted Aβ disruption can be achieved in circulation using
-    clinical diagnostic ultrasound transducers. Additional cell-based assays confirm
-    the ablated fragments are less toxic to neuronal and glial cells compared to mature
-    fibrils, and can be rapidly phagocytosed by both peripheral and brain macrophages.
-    These results highlight the potential of nanoemulsion contrast agents to deliver
-    new imaging enabled strategies for non-invasive management of Aβ-related diseases
-    using traditional diagnostic ultrasound modalities.
-  - The Hfq protein mediates gene regulation by small RNAs (sRNAs) in about 50% of
-    all bacteria. Depending on the species, phenotypic defects of an hfq mutant range
-    from mild to severe. Here, we document that the purified Hfq protein of the plant
-    pathogen and natural genetic engineer Agrobacterium tumefaciens binds to the previously
-    described sRNA AbcR1 and its target mRNA atu2422, which codes for the substrate
-    binding protein of an ABC transporter taking up proline and γ-aminobutyric acid
-    (GABA). Several other ABC transporter components were overproduced in an hfq mutant
-    compared to their levels in the parental strain, suggesting that Hfq plays a major
-    role in controlling the uptake systems and metabolic versatility of A. tumefaciens.
-    The hfq mutant showed delayed growth, altered cell morphology, and reduced motility.
-    Although the DNA-transferring type IV secretion system was produced, tumor formation
-    by the mutant strain was attenuated, demonstrating an important contribution of
-    Hfq to plant transformation by A. tumefaciens.
-  - Hfq is an RNA-binding protein that functions in post-transcriptional gene regulation
-    by mediating interactions between mRNAs and small regulatory RNAs (sRNAs). Two
-    proteins encoded by BAB1_1794 and BAB2_0612 are highly over-produced in a Brucella
-    abortus hfq mutant compared with the parental strain, and recently, expression
-    of orthologues of these proteins in Agrobacterium tumefaciens was shown to be
-    regulated by two sRNAs, called AbcR1 and AbcR2. Orthologous sRNAs (likewise designated
-    AbcR1 and AbcR2) have been identified in B. abortus 2308. In Brucella, abcR1 and
-    abcR2 single mutants are not defective in their ability to survive in cultured
-    murine macrophages, but an abcR1 abcR2 double mutant exhibits significant attenuation
-    in macrophages. Additionally, the abcR1 abcR2 double mutant displays significant
-    attenuation in a mouse model of chronic Brucella infection. Quantitative proteomics
-    and microarray analyses revealed that the AbcR sRNAs predominantly regulate genes
-    predicted to be involved in amino acid and polyamine transport and metabolism,
-    and Northern blot analyses indicate that the AbcR sRNAs accelerate the degradation
-    of the target mRNAs. In an Escherichia coli two-plasmid reporter system, overexpression
-    of either AbcR1 or AbcR2 was sufficient for regulation of target mRNAs, indicating
-    that the AbcR sRNAs from B. abortus 2308 perform redundant regulatory functions.
-- source_sentence: Neural correlates of advice evaluation and integration in the judge-advisor
+  - >-
+    Amyloid β (Aβ) assemblies exist not only in the central nervous system, but
+    can circulate within the bloodstream to trigger and exacerbate peripheral,
+    cerebrovascular, and neurodegenerative disorders. Eliminating excess
+    peripheral Aβ fibrils, therefore, holds promise to improve the management of
+    amyloid-related diseases. Here, we present nanoemulsion-mediated ultrasonic
+    ablation of circulating Aβ fibrils to both destroy established plaques and
+    prevent the re-growth of ablated fragments back into toxic species. This
+    approach is made possible using a de novo designed peptide emulsifier that
+    contains the self-associating sequence from the amyloid precursor protein.
+    Emulsification of the peptide surfactant with fluorous nanodroplets produces
+    contrast agents that rapidly adsorb Aβ assemblies and allows their
+    ultrasound-controlled destruction via acoustic cavitation. Vessel-mimetic
+    flow experiments demonstrate that nanoemulsion-assisted Aβ disruption can be
+    achieved in circulation using clinical diagnostic ultrasound transducers.
+    Additional cell-based assays confirm the ablated fragments are less toxic to
+    neuronal and glial cells compared to mature fibrils, and can be rapidly
+    phagocytosed by both peripheral and brain macrophages. These results
+    highlight the potential of nanoemulsion contrast agents to deliver new
+    imaging enabled strategies for non-invasive management of Aβ-related
+    diseases using traditional diagnostic ultrasound modalities.
+  - >-
+    The Hfq protein mediates gene regulation by small RNAs (sRNAs) in about 50%
+    of all bacteria. Depending on the species, phenotypic defects of an hfq
+    mutant range from mild to severe. Here, we document that the purified Hfq
+    protein of the plant pathogen and natural genetic engineer Agrobacterium
+    tumefaciens binds to the previously described sRNA AbcR1 and its target mRNA
+    atu2422, which codes for the substrate binding protein of an ABC transporter
+    taking up proline and γ-aminobutyric acid (GABA). Several other ABC
+    transporter components were overproduced in an hfq mutant compared to their
+    levels in the parental strain, suggesting that Hfq plays a major role in
+    controlling the uptake systems and metabolic versatility of A. tumefaciens.
+    The hfq mutant showed delayed growth, altered cell morphology, and reduced
+    motility. Although the DNA-transferring type IV secretion system was
+    produced, tumor formation by the mutant strain was attenuated, demonstrating
+    an important contribution of Hfq to plant transformation by A. tumefaciens.
+  - >-
+    Hfq is an RNA-binding protein that functions in post-transcriptional gene
+    regulation by mediating interactions between mRNAs and small regulatory RNAs
+    (sRNAs). Two proteins encoded by BAB1_1794 and BAB2_0612 are highly
+    over-produced in a Brucella abortus hfq mutant compared with the parental
+    strain, and recently, expression of orthologues of these proteins in
+    Agrobacterium tumefaciens was shown to be regulated by two sRNAs, called
+    AbcR1 and AbcR2. Orthologous sRNAs (likewise designated AbcR1 and AbcR2)
+    have been identified in B. abortus 2308. In Brucella, abcR1 and abcR2 single
+    mutants are not defective in their ability to survive in cultured murine
+    macrophages, but an abcR1 abcR2 double mutant exhibits significant
+    attenuation in macrophages. Additionally, the abcR1 abcR2 double mutant
+    displays significant attenuation in a mouse model of chronic Brucella
+    infection. Quantitative proteomics and microarray analyses revealed that the
+    AbcR sRNAs predominantly regulate genes predicted to be involved in amino
+    acid and polyamine transport and metabolism, and Northern blot analyses
+    indicate that the AbcR sRNAs accelerate the degradation of the target mRNAs.
+    In an Escherichia coli two-plasmid reporter system, overexpression of either
+    AbcR1 or AbcR2 was sufficient for regulation of target mRNAs, indicating
+    that the AbcR sRNAs from B. abortus 2308 perform redundant regulatory
+    functions.
+- source_sentence: >-
+    Neural correlates of advice evaluation and integration in the judge-advisor
     paradigm
   sentences:
-  - Considering advice from others is a pervasive element of human social life. We
-    used the judge-advisor paradigm to investigate the neural correlates of advice
-    evaluation and advice integration by means of functional magnetic resonance imaging.
-    Our results demonstrate that evaluating advice recruits the "mentalizing network,"
-    brain regions activated when people think about others' mental states. Important
-    activation differences exist, however, depending upon the perceived competence
-    of the advisor. Consistently, additional analyses demonstrate that integrating
-    others' advice, i.e., how much participants actually adjust their initial estimate,
-    correlates with neural activity in the centromedial amygdala in the case of a
-    competent and with activity in visual cortex in the case of an incompetent advisor.
-    Taken together, our findings, therefore, demonstrate that advice evaluation and
-    integration rely on dissociable neural mechanisms and that significant differences
-    exist depending upon the advisor's reputation, which suggests different modes
-    of processing advice depending upon the perceived competence of the advisor.
-  - The role of antibodies in kidney transplant (KT) has evolved significantly over
-    the past few decades. This role of antibodies in KT is multifaceted, encompassing
-    both the challenges they pose in terms of antibody-mediated rejection (AMR) and
-    the opportunities for improving transplant outcomes through better detection,
-    prevention, and treatment strategies. As our understanding of the immunological
-    mechanisms continues to evolve, so too will the approaches to managing and harnessing
-    the power of antibodies in KT, ultimately leading to improved patient and graft
-    survival. This narrative review explores the multifaceted roles of antibodies
-    in KT, including their involvement in rejection mechanisms, advancements in desensitization
-    protocols, AMR treatments, and their potential role in monitoring and improving
-    graft survival.
-  - Humans regulate intergroup conflict through parochial altruism; they self-sacrifice
-    to contribute to in-group welfare and to aggress against competing out-groups.
-    Parochial altruism has distinct survival functions, and the brain may have evolved
-    to sustain and promote in-group cohesion and effectiveness and to ward off threatening
-    out-groups. Here, we have linked oxytocin, a neuropeptide produced in the hypothalamus,
-    to the regulation of intergroup conflict. In three experiments using double-blind
-    placebo-controlled designs, male participants self-administered oxytocin or placebo
-    and made decisions with financial consequences to themselves, their in-group,
-    and a competing out-group. Results showed that oxytocin drives a "tend and defend"
-    response in that it promoted in-group trust and cooperation, and defensive, but
-    not offensive, aggression toward competing out-groups.
+  - >-
+    Considering advice from others is a pervasive element of human social life.
+    We used the judge-advisor paradigm to investigate the neural correlates of
+    advice evaluation and advice integration by means of functional magnetic
+    resonance imaging. Our results demonstrate that evaluating advice recruits
+    the "mentalizing network," brain regions activated when people think about
+    others' mental states. Important activation differences exist, however,
+    depending upon the perceived competence of the advisor. Consistently,
+    additional analyses demonstrate that integrating others' advice, i.e., how
+    much participants actually adjust their initial estimate, correlates with
+    neural activity in the centromedial amygdala in the case of a competent and
+    with activity in visual cortex in the case of an incompetent advisor. Taken
+    together, our findings, therefore, demonstrate that advice evaluation and
+    integration rely on dissociable neural mechanisms and that significant
+    differences exist depending upon the advisor's reputation, which suggests
+    different modes of processing advice depending upon the perceived competence
+    of the advisor.
+  - >-
+    The role of antibodies in kidney transplant (KT) has evolved significantly
+    over the past few decades. This role of antibodies in KT is multifaceted,
+    encompassing both the challenges they pose in terms of antibody-mediated
+    rejection (AMR) and the opportunities for improving transplant outcomes
+    through better detection, prevention, and treatment strategies. As our
+    understanding of the immunological mechanisms continues to evolve, so too
+    will the approaches to managing and harnessing the power of antibodies in
+    KT, ultimately leading to improved patient and graft survival. This
+    narrative review explores the multifaceted roles of antibodies in KT,
+    including their involvement in rejection mechanisms, advancements in
+    desensitization protocols, AMR treatments, and their potential role in
+    monitoring and improving graft survival.
+  - >-
+    Humans regulate intergroup conflict through parochial altruism; they
+    self-sacrifice to contribute to in-group welfare and to aggress against
+    competing out-groups. Parochial altruism has distinct survival functions,
+    and the brain may have evolved to sustain and promote in-group cohesion and
+    effectiveness and to ward off threatening out-groups. Here, we have linked
+    oxytocin, a neuropeptide produced in the hypothalamus, to the regulation of
+    intergroup conflict. In three experiments using double-blind
+    placebo-controlled designs, male participants self-administered oxytocin or
+    placebo and made decisions with financial consequences to themselves, their
+    in-group, and a competing out-group. Results showed that oxytocin drives a
+    "tend and defend" response in that it promoted in-group trust and
+    cooperation, and defensive, but not offensive, aggression toward competing
+    out-groups.
 pipeline_tag: sentence-similarity
 library_name: sentence-transformers
+language:
+- en
 ---
 
 # SentenceTransformer based on thenlper/gte-small
@@ -549,7 +597,7 @@ You can finetune this model on your own dataset.
 }
 ```
 
-#### If our work was helpful conside citing us ☺️
+#### If our work was helpful consider citing us ☺️
 ```bibtext
 @misc{sinha2025bicaeffectivebiomedicaldense,
       title={BiCA: Effective Biomedical Dense Retrieval with Citation-Aware Hard Negatives},